Helle Weber Ravn. Curriculum vitae. Ph.D. (Lic. Pharm.) Key qualifications

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1 Curriculum vitae Helle Weber Ravn Ph.D. (Lic. Pharm.) Key qualifications Senior scientist in organic chemistry (phytochemistry) related to environmental risk assessment of using pesticides. Head of PhytoChemLab, a biomarker laboratory at the Department of Terrestrial Ecology, National Environmental Reseach Institute, University of Aarhus, Denmark. Main research field: Biomarkers in biological organisms exposed to stress. Participatied in a research project on use of natural resources,such as macroalgae, to produce bio-ethanol. Expert in fast and easy methods for analysis of phytochemical compounds and patent applications. International co-ordinator of the IOC-FAO Programme on Harmful Algal Blooms at the Intergovernmental Oceanographic Commission of UNESCO, at the headquater in Paris, France, United Nations. Researcher in marine phytochemistry and toxicology and project leader of a National Harmful Algal Bloom project at the National Environmental Research Institute, Department of Marine Ecology and Microbiology. Expert in chemical analysis of toxins in phytoplankton. Ecotoxicology environmental research experiences on phytochemistry: Phenolic compounds as indicators for pollution in eelgrass. Previous research work ( ) in phytochemistry and biotechnology on cell culture tissue, project leading and planning, teaching master and Ph.D. students, organization and applications for research- and travel grants have been performed at the Department of Pharmacy, University of Copenhagen. Practical experience as laboratory pharmacist leader, including teaching of assistants, for one year before the Ph.D. study at the Department of Pharmacy, University of Copenhagen. International research experience in France and Japan. 1

2 Educations and work experiences Personal data April 1957, born in Øsby, Haderslev 1974 General Certificate of Education O-level (Realeksamen) 1977 General Certificate of Education A-level, mathematics and physics (Studentereksamen) 1984 Pharmacist degree (Cand.pharm) Pharmacist at Åbenrå Løveapotek and Haderslev Hjorteapotek Ph.D. student at the Royal Danish University of Pharmacy 1988 Ph.D. (Lic.pharm) 1988 Assistant Professor at the Institute of Pharmacognosy The Royal Danish University of Pharmacy 1989 Research Assistant at PharmaBiotec Research Center The Royal Danish University of Pharmacy Scientist at the Ministry of the Environment National Environmental Research Institute, Denmark Dept. of Marine Ecology and Microbiology International co-ordinator on Harmful Algal Bloom (Ass. Expert) Intergovernmental Oceanographic Commission, UNESCO, Headquarter, United Nations, Paris Senior Scientist at the Ministry of the Environment National Environmental Research Institute, Denmark Dept. of Terrestrial Ecology 1998 External examiner (Rapporteur) for Ph.D. project on: Biotransformation de l acide cinnamique par Plantago lanceolata cultive in vitro, (in French) Université Montpellier I, France External examiner The Royal Danish University of Pharmacy Head of PhytoChemLab (a biomarker laboratory) National Environmental Research Institute, Denmark Dept. of Terrestrial Ecology 2003 External examiner for Dr. thesis on: The role of selected plant and microbial metabolites in the nutrient solution on closed growing systems in greenhouses Acta Universitatis Agricultarae Sueciae 2007 Senior Scientist at the University of Aarhus National Environmental Research Institute, Denmark Dept. of Terrestrial Ecology 2007 Diploma in Leadership, Module 1: Personal Leadership, University of Aarhus, Herning 2008 Diploma in Leadership, Module 2: Leadership and Employees, University of Aarhus, Herning 2008 Diploma in Leadership, Module 3: Leadership and Organization, University of Aarhus, Herning 2008 Diploma in Leadership, Module 4: Strategic Leadership, Aarhus University, Herning 2008 Diploma in Leadership, Module 5: Leadership of Changes, Aarhus University, Herning 2

3 Languages Danish: Mother tongue German: Fair English: Excellent French: Excellent External courses Analysis of Chemical War Compounds C-30 (RDUP) EDB-Introduction course AD-42 (RDUP) Plant pathology 1B (051621) (RDUVA) Chemistry 2a1, Molecular spectroskopi (CU) Pharmaca and toxins from biological origin K-351 (RDUP) 7 th Nordic Postgraduate Course in Plant Pathology Plant Pathogenic Prokaryotes (RDUVA) Statistics for advanced students E-343 (RDUP) General training on research U-51 (RDUP) DANIDA Introduction Course No (31 January-13 February 1993) DANIDA Language Performance Training Course No.2/1993 (15 March-2 April 1993) UNESCO Training Course on Conducting Meetings (29-30 June 1993), UNESCO IOC-DANIDA Training Course on Taxonomy of Harmful Marine Phytoplankton (16-28 August 1993; CU) IOC-UNEP-WHO-FAO-Training Course on Qualitative and Quantitative Determination of Algal Toxins (18-28 October 1994; UJ) IOC-WESTPAC Training Workshop of PSP Plankton and Shellfish Toxicity (17-21 July 1995; KU) IOC-UNEP-WHO-FAO-Italy Training Course on Toxin Chemistry and Toxicology related to Harmful Algal Blooms (3-12 September 1995, UT) Project leader course, Samsø, 2001 Technical presentation, Silkeborg, 2005 Logical Framework Analysis (LFA), May 2002 (CBU) Business building course, Herning Business Council, 2004 Meeting facilities, Silkeborg, 20. February 2007 RDUP: The Royal Danish University of Pharmacy, Denmark CU: The University of Copenhagen, Denmark RDUVA: The Royal Danish University of Veterinary- and Agriculture, Denmark UJ: University of Jena, Germany KU: Kitasato University, Japan UT: University of Trieste, Italy CBU: Carl Bro University, Denmark UNESCO: Headquarter, Paris, France Research stays France Japan Université Montpellier I, Faculté de Pharmacie, (Prof. Dr. Claude Andary) 1987 (3,5 months), 1988 (1 month), 1989 (1 month), 1990 (1 month), 1991 (1,5 months), 1992 (1 month), 1997 (1 month), 2001 (2 weeks), 2002, 2003 (1 week), 2004 (2 weeks), 2005 (2 weeks), 2006 (2 weeks), 2007 (2 weeks), 2008 (2 weeks) 21 years of collaboration. Higashi-Nippon-Gakuen-University, Hokkaido (Prof. Dr. S. Nishibe), Tohoku University, Sendai (Prof. 3

4 Dr. T. Yasumoto, Dr. Y. Oshima), Kitasato University, Iwate Perfecture (Prof. Dr. M. Kodama) 1989 (1 month) & 1990 (5 weeks), Tohoku University, Sendai (Prof. Dr. T. Yasumoto, Dr. Y. Oshima) 1995 (1 month). U.S.A. College of Pharmacy, Kingston, University of Rhode Island (Prof. Dr. Y. Shimizu), Graduate School of Oceanograpy, University of Rhode Island (Prof. Dr. T.J. Smayda), University of Stony Brooks, Long Island (Dr. E. M. Cosper), Woods Hole Oceanographic Institution, (Dr. D.M. Anderson) 1991 (1 month), Environmental Protecting Agency (EPA), Cincinnatti (Director Sally Gutierrez) National and international project- and programme co-ordination National project leader Caffeic acid derivatives. Chemotaxonomical-, chemical-, analytical- and plants pathological aspects. Royal Danish University of Pharmacy, Copenhagen, Denmark National project leader/co-ordinator Toxic Algal Blooms in Danish Coastal Waters. National Environmental Research Institute, Dept. of Marine Ecology, Roskilde, Denmark International programme co-ordinator Harmful Algal Bloom Programme. Intergovernmental Oceanographic Commission, Science Sector of UNESCO, HQ, Paris, France National project leader Effects on aquatic environments of buffer zones along target water streams. National Environmental Research Institute, Dept. of Terrestrial Ecology, Silkeborg, Denmark National Project leader A new tool to farmers to evaluate herbicide effects on weeds at an early stage. National Environmental Research Institute, Dept. of Terrestrial Ecology, Silkeborg, Denmark National Project leader Herbicide resistance,development of a test-kit to evaluate herbicide resistance in plants National Environmental Research Institute, Dept. of Terrestrial Ecology, Silkeborg, Denmark Teaching experience Aabenraa Løveapotek & Haderslev Hjorteapotek Teaching chemist s assistants in pharmacy, 1-2 hours per week The Royal Danish University of Pharmacy Teaching students in pharmacognosy, plant morphology, content of compounds in plants and their pharmacology, toxic plants, and natural drugs (1 st years students) 81 teaching hours Teaching students in pharmacognosy, plant morphology, plant anatomy, identification of plants and fungi (2 nd years students) 225 teaching hours and 2 lectures in pharmacognosy (5 th years students) PharmaBiotec Research Centre, Institute of Pharmacognosy, The Royal Danish University of Pharmacy Practical and theoretical planning and organizing a training course in Secondary metabolites produced by plant cells in culture and hairy roots culture, making teaching materials and teaching students and Ph.D. students participating the course (8 colloquie hours and 20 practice hours in the laboratory) invited lectures in Denmark, Japan, Belgium, Norway, Italy, Germany, France, Finland Supervisor for 20 Danish, 1 Iranian, 1 French and 1 Japanese master students Preparing teaching materials for international training courses and workshops related to the the Intergovernmental Oceanographic Commission Harmful Algal Bloom Programme, UNESCO, Headquarter, Paris Supervisor for 3 Ph.D-students 4

5 Supervisor of master projects 1989 Caffeic acid glucosides, ontogenetical-, chemical-, analytical- and spectroscopical- aspects. Mona Birgitte Madsen & Charlotte Fogh Nielsen The Royal Danish University of Pharmacy 1989 Production of caffeic acid derivatives in cell culture of plants Birthe Holm, The Royal Danish University of Pharmacy 1990 Phenolic compounds from Plantago asiatica Li Xuebo Higashi-Nippon-Gakuen-University, Hokkaido, Japan 1991 Phenolic compounds in the root-parasite Striga spp. Christina Maria Højelse The Royal Danish University of Pharmacy (Performed at Université Montpellier I, Faculté de Pharmacie) 1991 Quantitative determination of rosmarinc acid and caffeic acid in Zostera marina L. Lone Mørk Pedersen & Hanne Toverud Plet, The Royal Danish University of Pharmacy (Performed at the National Environmental Research Institute, Roskilde) 1992 Qualitative and Quantitative determinations of hemolytical compounds from Chrysochromulina polylepis and Gyrodinium aureolum Lise Løhde & Janne Mattesen, The Royal Danish University of Pharmacy (Performed at the National Environmental Research Institute, Roskilde) 1992 Elicitation of the PSP-producing algae Alexandrium ostenfeldii Charlotte Urbak Schmidt & Hanne Sten, The Danish Engineer Academy (Performed at the National Environmental Research Institute, Roskilde) 1992 Phenolic compounds in eelgrass, Zostera marina Farzad Jahanshahi, The Royal Danish University of Pharmacy (Performed at the National Environmental Research Institute, Roskilde) 1992 Bioassay using Brine shrimp, Artemia salina as test organism Elvire Lemaire, Université Montpellier I, Faculté de Pharmacie (Performed at the National Environmental Research Institute, Roskilde) 1993 Toxicity of species of Chrysochromulina og Prymnesium Susanne Simonsen, University of Copenhagen (Partly performed at the National Environmental Research Institute, Roskilde) Phenolic compounds in plants as biomarkers for stress Kristine Andersen Krogh, University of Aarhus (Performed at the National Environmental Research Institute, Silkeborg) Plant biomarker pattern in Lolium perenne L. after exposure to biotic- and abiotic stress and use as an early warning system Kirsten Petersen, University of Aarhus (Performed at the National Environmental Research Institute, Silkeborg) Effects studies of herbicides on selected weed species Dorte Skovgaard Petersen, Southern University, Odense (Performed at the National Environmental Research Institute, Silkeborg) 2002 A new phytochemical screening programme used for organic and conventional crops Trine Christensen and Brigitte Diedrichsen, The Royal Danish University of Pharmacy (Performed at the National Environmental Research Institute, Silkeborg) Insecticide impact on freshwater microinvertebrates with special reference to the synthetic pyrethroid lambda-cyhalothrin and the amphipod Gammarus pules L. Lars-Henrik Heckmann, University of Aarhus (Performed at the National Environmental Research Institute, Silkeborg) Pesticide effects om cladocees behavios and biochemisty Birthe Thordal Christensen, University of Aarhus (Performed at the National Environmental Research Institute) 5

6 Screening of plant species with respect to a plant biomarker pattern to develompent of a new tool for evaluation of polyaromatic hydrocarbones (PAH) in soil and plants Marie Baunsgaard Pedersen, The Royal Danish University of Veterinary- and Agriculture (Performed at the National Environmental Research Institute, Silkeborg) Detection of chemical biomarkers in grass weed exposed to herbicides Maibritt Hjorth, University of Aarhus (Performed at the National Environmental Research Institute) Ph.D supervisor Seagrass response to organic loading of meadows caused by fish farming or eutrophication (part of EU MedVeg project) Morten Søby Frederiksen, Southern University, Odense Effect indicators in plants grown in herbicide polluted areas Iben Lykke Petersen, University of Copenhagen Comparative studies regarding the effect of environmental stress in endemic and common plant species using molecular biomarkers as indicators Adriana Jalba, University of Bucharest, Romania International meetings and courses Co-organizer of following meetings and courses 1993 The Second Session of the IOC-FAO Intergovernmental Panel on Harmful Algal Blooms, Paris, France, October 1994 PICES-IOC-SCOR-ICES Global Ocean Ecosystem Dynamics, Strategic Planning Conference, Paris, France, July 1994 Follow-up to UNCED (The Clima Change Convention): The Second International Meeting of Scientific and Technical Experts on Climate Change and the Ocean, Malta, 6-8 October 1994 IOC-WHO-FAO Training Course on Qualitative- and Quantitative Determination on Algal Toxins, Jena, Germany, October 1995 The Third Session of the IOC-FAO Intergovernmental Panel on Harmful Algal Blooms, Paris, France, 6-9 June 1995 IOC-WESTPAC Training Workshop of PSP Plankton and Shellfish Toxicity, Kitasato University, Japan, July 1995 IOC-UNEP-WHO-FAO-Italy Training Course on Toxin Chemistry and Toxicology related to Harmful Algal Blooms, University of Trieste, 3-12 September 2006 Environment and Stress Ph.D. Symposium of Danish Environmental Science Schools, The Royal Veterinary and Agricultural University (KVL), 7-8 November Active participating in following meetings 1991 & 1992 First BCR Intercomparison of Methods on the Analysis of Saxitoxin and other PSP Toxins in Solution BCR, Brussels 1991 IOC-SCOR Workshop on Programme Development for Harmful Algal Blooms Newport, Rhode Island, USA, 2-3 November 1992 ICES-IOC Study group on the Dynamics of Harmful Algal Blooms in Coastal Water Vigo, Spain, 7-8 April 1992 ICES-IOC ad hoc Planning Commitee Meeting on the Harmful Bloom Programme Vigo, Spain, 8-9 April 1993 The Seventeenth Session of the IOC Assembly, 25 February-11 March 1993 SCOR-IOC Working Group 97 on the Physiological Ecology of Harmful Algae, La Rochelle, France, 2-3 November 6

7 1994 Development of RM s for Paralytic Shellfish Poisons (PSP), Measurements & Testing Meeting, Brussels, May 1994 The Twenty-seventh Session of the IOC Executive Council, Paris, France, 5-13 July 1995 The Twenty-eighth Session of the IOC Executive Council, Paris, France, 12 June 1995 The Eighteenth Session of the IOC Assembly, June 1996 The IPCS INTOX Project Working Group on PIM s on Marine Toxins, Marseille, France 2-7 June 1996 XVIII th International Conference, Groupe Polyphénols, Bordeaux, July 1997 OECD Working Group on Test Guidelines for Terrestrial Plant Testing, OECD, Paris, 6-7 May 2006 Partnership for European Environmental Research (PEER) Environmental Technology Seminar with participation of the European Commission CEMAGREF, Agropolis International, Montpellier, October 2006 Osez l Europe de la recherché, 1 éres Rencontres Régionales sur les Programmes Européens de la recherche et de l innovation en Languedoc-Roussillon, Corum de Montpellier, October Publications, presentations and posters Patents 2000 International PCT- US patent application: An assay method and kit for testing biological material for exposure to stress using biomarkers (WO 01/92879 A1 PCT/DK01/00377) Application date: 30 May 2000 Inventor: Helle Weber Ravn Rights: National Environmental Research Institute 2007 International PCT-Patent application: A method and kit for testing stress effects in living organism (PA ) Application date: 7 January 2007 Inventor: Helle Weber Ravn Rights: National Environmental Research Institute & The Science and Agricultural Science Faculty, University of Aarhus (3:2) 2007 International PCT-Patent application: Method and kit for detecting resistance in living organism (PA ) Application date: 7 January 2007 Inventor: Helle Weber Ravn : Per Kudsk Nielsen : Solvejg K. Mathiassen (2:1:1) Rights: National Environmental Research Institute Institute & The Science and Agricultural Science Faculty, University of Aarhus (1:1) Scientific publications 1 Per Mølgaard & Helle Ravn (1988): Evolutionary aspects of caffeoyl esters in dicotyledons. A review. Phytochemistry, 27, 8, Helle Ravn & Leon Brimer (1988): Structure and antibacterial activity of Plantamajoside, a caffeic acid sugar ester from Plantago major ssp. major. Phytochemistry, 27, 11, C. Andary, H. Ravn, R. Wylde, A. Heitz and E. Motte-Florac (1989): Crassifolioside, a new caffeic acid glycoside esters from Plantago crassifolia. Phytochemistry, 28, 1, Helle Ravn, Claude Andary, Georg Kovacs & Per Mølgaard (1989): Caffeic acid esters as in vitro inhibitors of plant pathogenic bacteria and fungi. Biochem. Syst. and Ecology, Vol. 17, No 3, Helle Ravn (1988): 7

8 Caffeic acid derivatives. Chemotaxonomical-, chemical-, analytical- and plant pathological aspects, Ph.D.-Thesis. 6 Helle Ravn, Sansei Nishibe, Michiko Sasahara & Li Xuebo (1990): Phenolic componds from Plantago asiatica. Phytochemistry, Vol. 29, No. 11, pp Henning W. Petersen; Lone M. Petersen; Hanne T. Plet & Helle Ravn (1991): A new HPTLC fluorescens densitometric method for quantitative analysis of rosmarinic acid in extracts of Zostera marina L. Journal of Planar Chromatography, Vol.4, pp Helle Ravn; Morten F. Pedersen; Jens Borum; Claude Andary; Uffe Anthoni; Carsten Christophersen & Per H. Nielsen (1994): Seasonal variation of two phenolic compounds, rosmarinic acid and caffeic acid, in eelgrass (Zostera marina L.). Ophelia, Vol. 40, No. 1, pp Helle Ravn; Charlotte U. Schmidt; Hanne Sten; Uffe Anthoni, Carsten Christophersen & Per Halfdan Nielsen (1995): Elicitation of Alexandrium ostenfeldii (dinophyceae) affects the toxin profile. Comp. Biochem. Physiol., Vol. 111C, No. 3, pp Helle Ravn; Uffe Anthoni; Carsten Christophersen, Per Halfdan Nielsen & Yasukatsu Oshima (1995): Standardized Extraction method for Paralytic Shellfish Toxins in Phytoplankton. Journal of Applied Phycology, 7, pp M. Holmstrup, H. Sjursen, M. Bayley and H. W. Ravn (2001): Dehydration tolerance and water vapour absorption in two species of soil-dwelling Collembola by accumulation of sugars and polyols. Functional Ecology, 15, Thomas Larsen, Jørgen Axelsen & Helle Weber Ravn (2004): Simplified and rapid method for extraction of ergosterol from natural samples and detection with quantitative and semi-quantitative methods using thin layer chromatography. Journal of Chromatography, A. 1026, Heckmann, L.-H., Friberg, N. & Ravn, H.W. (2005): Relationship between biochemical biomarkers and precopulatory behaviour and mortality in Gammarus pulex following pulse-exposure tolambda-cyhalothrin. Pest Management Science, 61, Christensen, B.T., Lauridsen, T.L., Ravn, H.W. & Bayley, M. (2005): A comparison of feeding effiency and swimming ability of Daphnia magna exposed to cypermethrin. Aquatic Toxicology, 73, Ravn, H.W., Cedergreen, N. & Løkke, H. (2005): Phytochemical biomarkers in eight aquatic plant species exposed to metsulfuron-methyl. Bull. Environ. Contam. Toxicol., 74, Ravn, H.W., Hjorth, M., Lauridsen, L., Kudsk, P., Mathiassen, S.K. & Mondolot, L. (2005): New phytochemical screening method for biomarkers in plants exposed to herbicides. Bull. Environ. Contam. Toxicol., 75, Hjorth, M., Mondolot, L., Buatois, B., Andary, C., Rapior, S., Kudsk, P., Mathiassen, S.K. & Ravn, H.W. (2006): An easy and rapid method using microscope to determine herbicide effects in Poaceae weed species. Pest Manag. Sci., 62, Hjorth, M., Mathiassen, S.K., Kudsk, P. & Ravn, H.W. (2006): Amino acids in loose silky-bent (Apera spica-venti (L.) Beauv.) responding to prosulfocarb exposure and the correlation with physiological effects. Pesticide Biochemistry and Physiology, 86, Solvejg K. Mathiassen, Helle W Ravn & Per Kudsk (2007): Is dose-splitting of graminicides as effective as a single application? Weed Research, 47 (3), Iben Lykke Petersen, Hans Christian Bruun Hansen, Helle Weber Ravn, Jens Christian Sørensen & Hilmer Sørensen (2007): Metabolic effects in rapeseed (Brassica napus L.) seedlings after root exposure to glyphosate. 8

9 Pesticide Biochemistry and Physiology, 89, Ravn, H.W. (2009): Two new methods for early detection of herbicide effects in plants using biomarkers. J. of Planar Chromatography (In press). 22 Kristine Maraldo, Helle Weber Ravn, Stine Slotsbo, Martin Holmstrup (2009): Responses to acute and chronic desiccation stress in Enchytraeus (Oligochaeta: Enchytraeidae). J. of Comp Physiol B (In press). Reports 1 Jacob Larsen, Per Juel Hansen & Helle Ravn (1993): Giftige alger i danske farvande. Havforskning fra Miljøstyrelsen, nr. 28, Miljøstyrelsen, Miljøministeriet. 2 Henrik Enevoldsen & Helle Ravn (1993): The Second Session of the IOC-FAO Intergovernmental Panel on Harmful Algal Blooms. Paris, France, October, Intergovenmental Oceanographis Commission. Reports of Govering and Major Subsidiary Bodies, UNESCO. 3 Gunnar Kullenberg & Helle Ravn (1994): The Second International Meeting of Scientific and Technical Experts on Climate Change and the Ocean. Malta, 6-8 October, Intergovenmental Oceanographic Commission, Reports of Meetings of Experts and Equivalent Bodies, UNESCO. 4 Helle Ravn & Bernd Luckas (1994): IOC-WHO-FAO Training Course on Qualitative- and Quantitative Determination on Algal Toxins. Jena, Germany, October, Training Course Reports No Helle Ravn & Henrik Enevoldsen (1995): The Third Session of the IOC-FAO Intergovernmental Panel on Harmful Algal Blooms. Paris, France, 6-9 June, Intergovenmental Oceanographis Commission, Reports of Govering and Major Subsidiary Bodies, UNESCO. 6 Helle Ravn & Takeshi Yasumoto (1995): IOC-WESTPAC Training Workshop of PSP Plankton and Shellfish Toxicity. Kitasato University, Japan, July, Training Course Reports No. 36, UNESCO. 7 Helle Ravn & Aurelia Tubaro (1995): IOC-UNEP-WHO-FAO-Italy Training Course on Toxin Chemistry and Toxicology related to Harmful Algal Blooms. University of Trieste, 3-12 September, Training Course Reports No. 35, UNESCO. 8 Helle Ravn & Takeshi Yasumoto (1995): Amnesic Shellfish Poisoning (ASP). Volume 1, HAB Publication Series, Intergovernmental Oceanographic Commission, Manuals and Guides No. 31, UNESCO. 9 Helle Ravn (1998): Ecotoxicological evaluation of fluoroglycofen-ethyl. Confidential report. 10 Helle Ravn (1999): Detection of herbicide spraying in spraying-free areas using plant biomarkers, M Confidential report, Helle Weber Ravn & Lise Lauridsen (2003): Et nyt værktøj til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Rapport: Screening af eksponerede planter for biomarkører. Projekt nr Å Fortrolig rapport. 12 Helle Weber Ravn & Nikolai Friberg (2004): Effekt på akvatiske miljøer af randzoner langs målsatte vandløb. Pesticidhandlingsplan II, Faglig rapport fra DMU, nr. 487, Helle Weber Ravn, Maibritt Hjorth & Lise Lauridsen (2005): Et nyt værktøj til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Rapport: Identifikation af biomarkører, metodeudvikling, arbejdsprogram (AP) 3. 9

10 Projekt nr. 93S-2465-Å Fortrolig rapport, Helle Weber Ravn (2006) Et nyt værktøj til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Rapport: Afprøvning af 1. rå-prototype af test-kit hos landmænd og konsulenter 2006, arbejdsprogram (AP) 7. Projekt nr. 93S-2465-Å Fortrolig rapport, Helle Weber Ravn, Per Kudsk, Solvejg K. Mathiassen & Hanne K. Kristensen (2006) Et nyt værktøj til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Rapport: Semi-field og markforsøg til validering af test-kit, arbejdsprogram (AP) 5 & 6. Projekt nr. 93S-2465-Å (Fortrolig rapport), Helle Weber Ravn (2007) Et nyt værktøj til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Slut- Rapport. Projekt nr. 93S-2465-Å (Fortrolig rapport), Popular publications and radio- and TV programmes 1 Britta Pedersen & Helle Ravn (1990): Miljøfarlige stoffer. Naturen i Havet, Skov- og naturstyrelsen, s Henrik Enevoldsen & Helle Ravn (1992): Giftige alger og algeopblomstringer. Vand & Miljø, 6, s Ravn, H.W. (2000): Plantebiomarkører som stressindikatorer for miljøpåvirkninger. - Miljø og sundhed, 14, Ingeniøren (Henrik Jensen, October 2001): Ny dansk test kan afsløre gift i mad (about the work of Helle Weber Ravn). 5 TV2 news kl 22 (October 2001): Ny dansk test kan afsløre gift i mad (about the work of Helle Weber Ravn). 6 Grønspiren (Johs. Aagaard, February 2002): Billig og nem test afslører sprøjtegift i planter (about the work of Helle Weber Ravn). 7 International Environment Reporter, Vol. 25, No. 6 (Stephen Joyce, 13 March 2002) Inexpensive, simple process for analyzing plant stress developed by danish scientist (about the work of Helle Weber Ravn). 8 AVJ-info fra Amternes Videnscenter for Jordforurening 6/2002: Planter afslører pesticidforurenede grunde. 9 Helle Weber Ravn, Lise Lauridsen, Hans Løkke, Nikolai Friberg, Annette Baattrup-Pedersen & Kurt Nielsen (2003): Sprøjtemidler på afveje. Aktuel naturvidenskab, 3, s Kudsk, P., Mathiassen, S., Ravn, H.W. & Lauridsen, L. (2005): Splitdoseringer, biomarkører og sparede herbicider. Agrologisk, Ravn, H.W. (2005): Vers une meilleure utilisation des herbicides grâce à de nouvelles mèthodes pour détecter leurs effets sur les plantes nuisibles aux cultures. Bulletin Scientifique et Universitaire, 8, Lars Bødker Smitt (2006) Testkit kan tidligt påvise effekt af ukrudtsmidler (about the work of Helle Weber Ravn). MARK, Februar, Kristin Fridholm (2006) Testkit avslöjarotillräcklig sprutning (about the work of Helle Weber Ravn). Lantbrukets Affärer, 3, MOSTRA-Communication (film for European Commision) (work of Helle Weber Ravn included as 10

11 demonstration of prototype of test-kit and interview). Europe to ensure the correct use of pesticides. (Running time: 11 05) 15 Helle Weber Ravn (1 times interview i direkte udsendelse med Diana Bach) (2007) Hvad forsker vi i? Fra Planteindholdsstoffer til faktura! Danmarks Radio (P4) Østjylland, 14 November 16 Vagn I. Pertl (2006) Nedsat dosering på sikker grund (about the work of Helle Weber Ravn) Effektivt Landbrug, 2 December, Kristin Fridholm (2007) Tillräcklig sprutdos? Snabbtest ger svaret (about the work of Helle Weber Ravn) Lantbrukets Affärer, no Per Emgardsson (2007) Planttankar Snabbtest av spruteffekt Lantmannen, February, Ove Hoeg Christensen (2007) Ukrudt testes for virkning af sprøjtemidler (about the work of Helle Weber Ravn) 18 January 20 Jordbruksaktuelt ( ) Snabbtest för ogräseffekt, 21 Monica Kling (2007) Snabbt besked om bekämpningseffekt, Nyhed från Greppa Näringen Invited lectures 1989 Higashi-Nippon-Gakuen-University, Hokkaido, Japan: The chemical structure, occurence and analysis of caffeic acid derivatives seen in a plant pathological perspective Japan Pharmacognostical Society 37 th Annual Meeting, Chiba, Tokyo: Phenolic compounds from Plantaginis Herba National Institute of Hygienic Sciences, Tokyo, Japan: Caffeic acid derivatives, biological active compounds Analytical Chemical Symposium, The Technical University, Denmark: HPLC-analysis of Paralytic Shellfish Poison (PSP) from plankton Algae Danish Society of Environmental Chemistry, The Institute of H.C. Ørsted, University of Copenhagen: Chemistry and Toxicology of Toxic Algae The Ring of Analysts, The Section of the Danish Pharmaceutical Society, National Environmental Research Institute, Roskilde: Analytic Chemical Aspects of Toxins from Plankton Algae IOC-DANIDA Training Course on Harmful Marine Phytoplankton, University of Copenhagen: Toxicological and Toxin Chemistry Aspects of Phytoplankton Unit C: Measurements & Testing Programme Meeting, Directorate General XII, Science, Research and Development, Commission of the European Communities, Brussels: The International Programme on Harmful Algal Bloom, activities within the Scientific elements of Toxin Chemistry and Toxicology University of Bergen, Department of anatomy and Cell Biology, Norway: The development of the Joint IOC-FAO International Programme on Harmful Algal Blooms IOC-UNEP-WHO-FAO-Training Course on Qualitative and Quantitative Determination of Algal Toxins, Friedrich-Schiller University of Jena, Germany: Harmful Algal Bloom, An International Programme in Development. 11

12 1995 The Seventh International Conference on Toxic Phytoplankton, Sendai, Japan: The Development of the Joint IOC-FAO International Programme IOC-WESTPAC Training Workshop of PSP Plankton and Shellfish Toxicity, Kitasato University, Japan: The Educational Elements of the Harmful Algal Blooms IOC-UNEP-WHO-FAO-Italy Training Course on Toxin Chemistry and Toxicology related to Harmful Algal Blooms, University of Trieste: 1) The Educational Elements of the Harmful Algal Blooms. 2) Toxicological and Chemical Aspects of Paralytic Shellfish Poisoning (PSP) th IUPAC Symposium on Mycotoxins and Phycotoxins Instituto Superiore di Sanita, Rome: Management strategies for phycotoxin control IOC-DANIDA Course on Taxonomy of Harmful Marine Phytoplankton, University of Copenhagen: 1) Marine Phytoplankton, Toxicological and Toxin Chemistry Aspects of Phytoplankton, I. 2) Marine Phytoplankton, Toxicological and Toxin Chemistry Aspects of Phytoplankton, II NORFA Workshop on Biological Active Secondary Metabolites in Plants, Technical Research Centre of Finland (VTT), Espoo, Finland: Caffeic acid derivatives, biological active compounds The Environmental Medical Research Centre of the Ministry of Health, Eigtveds Pakhus, Copenhagen: Plantebiomarkører som stressindikatorer for miljøpåvirkninger Workshop concerning soil ecology, National Environmental Research Institute, Silkeborg: Plantbiomarkers Meeting concerning streams, springs and lakes, Scandic Hotel, Silkeborg: Biomarkers A new tool to pesticide studies an early warning Université Montpellier I, France: Substances naturelles et valorisation gestion de l environnement, double lecture (in French) The Royal Danish University of Pharmacy, Copenhagen: Biomarkører i planter ved herbicideksponering Université Montpellier I, France: Substances naturelles et valorisation gestion de l environnement, double lecture (in French) University of Aarhus: Biomarkørmønstre et nyt redskab til økotoksikologiske studier Århus Amts Erhvervsafdeling: Nye analysemetoder indenfor jordforurening (temadag) University of Southern Denmark, Odense: Plant Biomarker Pattern A New Tool for Ecotoxicological Studies University of Aarhus: Biomarkørmønstre et nyt redskab til økotoksikologiske studier XVII International Botanical Congress, Vienna, Austria, July: The stress effects of NH 4 + deposition in Thymus pulegioides L. using biomarker as indicator, Jalba, A., Ravn, H.W. & Løkke, H. (Presented by Jalba, A.) Centre d Ecologie Fonctionelle et Evolutive, Montpellier, France, 7, Centre Nationale de la Recherche Scientific (CNRS): Detection precoce de biomarqueurs dans de mauvaises herbes stressees par herbicides. (In french) Plantekongres 2006, Congress Center of Herning, Denmark, January: Har ukrudtsmidlet virket? Et nyt kit præsenteres (1.7.3 Planteværn) Frøavlerårsmøde, Ringsted, Denmark, 8 January: Et nyt test-kit til herbicideffektmåling. 12

13 2007 Plantekongres 2007, Congress Center of Herning, Denmark, 9-10 January: Agromek 2007, Messecenter Herning, Denmark,15-20 January: Herbicide Weed Response Test to Sulfonylurea herbicides HWR -Test S Et nyt test-kit til herbicideffektmåling Environmental Protection Agency (EPA) Science Forum 2008,Innovative Technologies: Key to Environmental and Economic Progress, Washington, May 20-22: European Union Environmental Programmes Exemplified by Projects in a Danish Environmental Research Institute Environmental Protection Agency (EPA), Cincinatti, USA, May 27, Environmental Research in Denmark -Department of Terrestrial Ecology National Environmental Research Institute (NERI) University of Aarhus (AU) International Symposium for Thin Layer Chromatography, HPTLC, Helsinki, June: New test-kits to detect herbicide effects and resistance in Weed plants based on HPTLC-Screening Copenmind 2008, Copenhagen exhibition of research, Technology, Innovation, 1-3 September: Herbicide Weed Response HWR-Test kit. Posters 1 Per Mølgaard, Leon Brimer & Helle Ravn (1984): Caffeic acid in Plantago. Preliminary Report at the 24 th Annual Meeting of PSNA, Boston 2 Helle Ravn (1987): The potential effect of Caffeic acid derivatives as natural plant protective measures, illustrated by the antibacterial activity against certain plant pathogenic bacteria. The 7 th Nordic Postgraduate Course in Plant Pathology. Tune, Denmark, June. 3 Helle Ravn, Karen Christensen & Per Mølgaard (1988): Evolution and distribution of caffeic acid i dicotyledon plants. The biological activity illustrated by excamples. The 9 th Symposium of Nordic Natural Compounds. Hirtshals, Denmark, June. 4 Birthe Holm, Helle Ravn & Ulf Nymann (1990): Effects of 2,4-D and kinetin on the Callus Initiation and Accumulation of Caffeoyl Esters in Callus Cultures of Forsythia suspensa. International Joint Symposium of: Gesellschaft fhr Arzneipflanzenforschung American Society of Pharmacognosy, Association Francaise pour l Enseignement et la Recherche en Pharmacognosie, Phytochemical Society of Europe, Bonn, Germany July. 5 Helle Ravn (1991): Toxic Algal Blooms in Danish Coastal Waters, A New Project. Colloque International, Biotoxines Marines, CNEVA, Paris January. 6 Lone Mørk Petersen, Hanne Plet, Henning W. Petersen & Helle Ravn (1991): A new thin layer chromatographic fluorescense densitometric method for quantitative analysis of rosmarinic acid in extracts of Zostera marina L. The sixth International Symposium on Instrumental Planar Chromatography, Interlaken, Schweitz, May. 7 Gitte Nielsen, Hanne Kaas & Helle Ravn (1991): Vertical migration of Gyrodinium aureolum in an artificial water column. Fifth International Conference on Toxic Marine Phytoplankton, Newport, Rhode Island, USA, 28 October-1 November. 8 H. Ravn, M.F. Pedersen, J. Borum, C. Andary, U. Anthoni, C. Christophersen & P.H. Nielsen (1992): Seasonal variation of rosmarinic acid, caffeic acid, nitrogen and phosphorous in different parts of leaves and rhizomes/roots of Zostera marina L. Det 7. danske havforskermøde, Aarhus, January. 9 S. Nishibe, M. Sasahara, Y. Noro, T. Kawamura, T. Tanaka (Japan), C. Yuan, Y. Jiao (China), C. Andary (France) & H. Ravn (1992): Chemical structures of phenols from Plantago Herb and their physiological effects. XVI th International Conference, Groupe Polyphenols, Lisboa, Portugal, July. 10 H. Ravn, V. Forbes, C. Andary, C. Christophersen & F. Jahanshahi (1992): Phenolic compounds in the marine plant, Zostera marina L. 13

14 XVI th International Conference, Groupe Polyphenols, Lisboa, Portugal, July. 11 V. Forbes, H. Ravn & F. Jahanshahi (1993): Biochemical and energetic responses to stress in Zostera marina. 12 S. Simonsen, B.L. Møller, J. Larsen & H. Ravn (1993): Haemolytical activity of Alexandrium tamarense cells. Sixth International Conference on Toxic Marine Phytoplankton, Nantes, France, October. 13 H. Enevoldsen & H. Ravn (1993): Development within the IOC Harmful Algal Bloom Programme since the Fifth International Conference on Toxic Marine Phytoplankton. Sixth International Conference on Toxic Marine Phytoplankton, Nantes, France, October. 14 H. Ravn & H. Enevoldsen (1995): Development within the IOC Harmful Algal Bloom Programme since the Sixth International Conference on Toxic Marine Phytoplankton. Seventh International Conference on Toxic Phytoplankton, Sendai, Japan, July. 15 Ravn, Helle, Krogh, Kristine, A. & Andary, Claude (1998): Plant phenolic compounds as potential biomarkers for abiotic and biotic stress. XIX th International Conference, Groupe Polyphenols, Lille, France. 16 Ravn, H., Krogh, K.A. & Andary, C. (1999): Phenolic Compounds as Potential Biomarkers for Abiotic and Biotic stress. Dansk Miljøforskning, The Institute of H.C. Ørsted, University of Copenhagen, August. 17 Helle Weber Ravn, Ingelise Lauridsen, Charlotte Vestergaard Kristensen & Dorte Skovgaard Petersen (2002): Plantebiomarkører En ny metode til effektstudie af herbicideksponerede planter. 1) Vandplanternes Biologi, Salten Skov, January; 2) 19. Planteværnskonference, Hotel Nyborg Strand, 5-6 March. 18 Helle Weber Ravn, Hans Løkke & Ingelise Lauridsen (2002): Plant Biomarker Pattern A new tool for effect studies of plants exposed to herbicides. 1) 19. Planteværnskonference, Hotel Nyborg Strand, 5-6 March; 2) SETAC, Vienna, Austria, May. 19 Helle Weber Ravn, Hans Løkke & Jan Buch Andersen (2002): PlantMark A simple kit/assay for screening af stress exposure in plants. 19. Planteværnskonference, Hotel Nyborg Strand, 5-6 March. 20 Helle Weber Ravn, Hans Løkke, Ingelise Lauridsen & Annette Baattrup-Pedersen (2002): Plant Biomarker Pattern Herbicide exposure in buffer zones. SETAC, Vienna, Austria, May and Natur- og Miljøkonference, The Institute of H.C. Ørsted, University of Copenhagen, August. 21 Trine F. Christensen, Brigitte Diedrichsen, Anne Adsersen, Jan Buch Andersen & Helle Weber Ravn (2002): Plant Biomarker Pattern Screening Programme for Detection of Phytoichemical Differences in Plants Exposed to Stress. Natur- og Miljøkonference, The Institute of H.C. Ørsted, University of Copenhagen, August. 22 Charlotte V. Christensen, Helle Weber Ravn & Nina Cedergreen (2002): Plant Biomarker Pattern Assessment of aquatic plants sensitivity towards the herbicide metsulfuron methyl. Natur- og Miljøkonference, The Institute of H.C. Ørsted, University of Copenhagen, August. 23 Helle Weber Ravn, Ingelise Lauridsen, Per Nielsen Kudsk, Solvejg Kopp Mathiassen & Hans Roust Thysen (2003): Plant Biomarker Pattern - A new tool to evaluate herbicide effects on plants using thin layer chromatography (TLC). International Symposium for Thin Layer Chromatography, Palais de Congrès, Lyon, France, October. 14

15 24 Iben Lykke Petersen, Jan H. Christensen, Hilmer Sørensen, Helle Weber Ravn and Hans Christian Bruun Hansen (2006): Metabolic fingerprinting of crude plant extracts using Q-TOF Mass Spectrometry. 1) 4 th International Conference on Plant Metabolomics, The Royal Danish University of Veterinary- and Agriculture, Denmark, 7-10 April; 2) Symposium of Danish Environmental Science Schools: Environment and Stress, Reading, England, 7-8 November 25 Helle Weber Ravn, Lise Lauridsen, Per Kudsk, Solvejg K. Mathiassen, Hanne K. Kristensen & Maibritt Hjorth (2006): Plant Biomarker Pattern High Performance Thin-Layer Chromatography (HPTLC) used to detect a phytochemical pattern in five different plant species after exposure to glyphosate. 1) International Symposium for High Performance Thin-Layer Chromatography, Berlin, 9-11 October 2) Plantekongres 2007, Congress Center of Herning, Denmark, 9-10 January 26 Helle Weber Ravn, Lise Lauridsen, Per Kudsk, Solvejg K. Mathiassen, Hanne K. Kristensen & Maibritt Hjorth (2006): Plant Biomarker Pattern Phytochemical pattern in Apera spica-venti after exposure to six different herbicides using High Performance Thin-Layer Chromatography (HPTLC). 1) International Symposium for High Performance Thin-Layer Chromatography, Berlin, 9-11 October; 2) Symposium of Danish Environmental Science Schools: Environment and Stress, Reading, England, 7-8 November 27 Helle Weber Ravn, Per Kudsk, Solvejg K. Mathiassen, Hanne K. Kristensen & Ervind Müller (2006): A new innovative technology to promote the use of reduced herbicide doses in arable crops. Partnership for European Environmental Research (PEER) Environmental Technology Seminar with participation of the European Commission CEMAGREF, Agropolis International, Montpellier, October 28 Helle Weber Ravn, Per Kudsk, Solvejg K. Mathiassen, Hanne K. Kristensen & Ervind Müller (2007): Et nyt test-kit til landmænd til hurtig og tidlig vurdering af herbicideffekter på ukrudtsplanter. Plantekongres 2007, Congress Center of Herning, Denmark, 9-10 January 29 Helle Weber Ravn, Lise Lauridsen, Per Kudsk, Solvejg K. Mathiassen & Ervind Müller (2008): Herbicide resistance. A new test-kit to detect resistance in Papaver rhoeas. International Symposium for Thin Layer Chromatography, HPTLC, Helsinki, June 30 Kristine Maraldo, Helle Weber Ravn, Stine Slotsbo & Martin Holmstrup (2008): Drought strategies in Enchytraeus albidus. Annual Main Meeting of the Society for Experimental Biology, Marseille, France, 6-10 July 15