Ovarian Cancer (Event Driven)

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1 Brochure More information from Ovarian Cancer (Event Driven) Description: Owing to the lack of screening programs across the markets under study, ovarian cancer (CaO) typically goes undetected until advanced-stage disease, when prognosis is poor. Chemotherapies used to treat CaO have little impact on the prognosis of advanced-stage disease, and the current first-line gold-standard, a heavily generic chemotherapy regimen, is yet to be challenged by new therapy approvals. The unmet need in CaO offers significant opportunity to drug developers, particularly those developing targeted agents; no such agents have yet reached the CaO armamentarium. Optimism surrounds several late-stage emerging therapies, in particular Roche/Genentech/Chugai s bevacizumab (Avastin), which is likely to be approved in Europe imminently. Over our study period, we anticipate dramatic growth in this market, owing to the approval of several premium-priced emerging therapies. Contents: Executive Summary What are the key parameters of the ovarian cancer market? What factors are driving the market for ovarian cancer therapies? What factors are constraining the market for ovarian cancer therapies? What are the drug development activities of note in ovarian cancer? What do the experts say? What key challenges and opportunities remain? 1 Etiology and Pathophysiology Disease Pathophysiology Histology Genetic Risk Factors Inherited Genomic Factors Acquired Genomic and Proteomic Factors Grading and Staging Symptoms Prognostic Factors Tumor Stage Tumor Histology Peritoneal Fluid Cytology Age Volume of Residual Disease CA-125 Levels Pathways and Drug Targets PARP Vascular Endothelial Growth Factor Epithelial Cell Adhesion Molecule Folate Receptor CA-125 EGFR Inhibitors 2 Epidemiology and Patient Populations Disease Definition Methods Newly Diagnosed Incident Cases Recurrent Incident Cases Subpopulations Stage at Diagnosis Diagnosed and Drug-Treated Populations Percentage Diagnosed Percentage Drug-Treated Drug-Treated Populations Early-Stage First Line

2 Advanced-Stage First Line Second-Line Platinum-Sensitive Second-Line Platinum-Resistant and -Refractory Third Line Fourth Line and Subsequent Lines 3 Current Therapies and Medical Practice Diagnosis Treatment Guidelines Clinical Trial End Points Drug Treatment Commonly Prescribed Drugs Regimen Dosing Clinical Analysis of Therapies Used to Treat Early-Stage Ovarian Cancer Clinical Analysis of Therapies Used to Treat First-Line Advanced Ovarian Cancer Clinical Analysis of Second-Line Therapies Used to Treat Advanced Ovarian Cancer Platinum-Sensitive Ovarian Cancer Platinum-Resistant and -Refractory Ovarian Cancer Clinical Analysis of Therapies Used to Treat Third- and Subsequent-Line Advanced Ovarian Cancer Histological Patient Subpopulations Clinical Development General Treatment Algorithm Country-Specific Treatments Intraperitoneal Chemotherapy Treatment of Malignant Ascites Trabectedin Japanese Medical Practice Reimbursement 4 Unmet Needs Preventing Progression to Platinum-Resistant Disease Better Treatment Options for Platinum-Resistant and -Refractory Ovarian Cancer Individualized Treatment for Ovarian Cancer Patients Increased Clinical R&D to Identify Novel Therapeutic Targets Effective Screening for Earlier Detection 5 Emerging Therapies Future Positioning of Key Competitors Early-Stage Therapies Drug Development and Regulatory Hurdles Angiogenesis Inhibitors Bevacizumab (Avastin) AMG-386 Cediranib (Recentin) Pazopanib (Votrient) BIBF-1120 PARP Inhibitors Olaparib (AZD-2281) Iniparib (BSI-201) Folate Receptor Targeting Agents Farletuzumab (MORAB-003) EC-145 Immunotherapies

3 Abagovomab (ACA-125) Catumaxomab Epidermal Growth Factor Receptor Inhibitors Erlotinib (Tarceva) Modified Cytotoxics Paclitaxel Poliglumex (CT-2103, Opaxio [formerly Xyotax]) OAS-PAC-100 (Paclical/Pacliex) Nanoparticle Paclitaxel (Abraxane) Cositecan (BNP-1350/Karenitecin) NKTR Market Outlook Segment-Specific Trends Early-Stage Ovarian Cancer First-Line Treatment Advanced-Stage Ovarian Cancer First-Line Treatment Platinum-Sensitive Ovarian Cancer Second-Line Treatment Platinum-Resistant and -Refractory Ovarian Cancer Second-Line Treatment Ovarian Cancer Third and Subsequent Lines of Treatment Alternative Market Scenarios Appendix A Bibliography Appendix B Market Forecast Methodology Bottom-Up Market Forecasting Patient Populations Drug-Specific Assumptions General Sources of Data Pricing, Dosing, Days of Therapy, and Compliance Assumptions General Statements About Pricing Dosing, Cycles and Compliance Generics Erosion Emerging Therapy Prices Bevacizumab Olaparib Farletuzumab EC-145 AMG-386 Appendix C Experts Interviewed Ovarian Cancer Tables and Figures Table 1-1 Risk Factors Associated with Ovarian Cancer Table 1-2 Acquired Genomic and Proteomic Factors Associated with Sporadic Ovarian Cancer Table 1-3 International Federation of Gynecology and Obstetrics Staging System for Primary Carcinoma of the Ovary Table 2-1 Number of Diagnosed Incident Cases of Ovarian Cancer in the Major Pharmaceutical Markets, by Stage Distribution, Table 2-2 Ovarian Cancer Drug-Treatable Populations in the Major Pharmaceutical Markets, by Stage at Diagnosis, Table 2-3 Key Sources for Ovarian Cancer Epidemiology and Model Parameters Table 3-1 Treatment Providers and Diagnostic Patterns in the Major Markets for Ovarian Cancer Table 3-2 Ovarian Cancer Treatment Guidelines by Market Table 3-3 Key End Points Used in Clinical Trials for Ovarian Cancer Table 3-4 Brand and Manufacturer of Current Therapies to Treat Ovarian Cancer

4 Table 3-5 Current Therapies Used for Ovarian Cancer Table 3-6 Current Regimen Dosing for Ovarian Cancer Table 3-7 Efficacy Achievements for Early-Stage Ovarian Cancer Table 3-8 Efficacy Achievements for Advanced-Stage Ovarian Cancer Table 3-9 Most Frequent Toxicities Encountered During Treatment of Advanced-Stage Ovarian Cancer Table 3-10 Select Phase III Trials Investigating PLD in the Treatment of Ovarian Cancer Table 3-11 Most Commonly Prescribed Regimens for Ovarian Cancer by Line Table 3-12 Expert Insight: Therapies Used to Treat Ovarian Cancer Table 3-13 Reimbursement Environment for Ovarian Cancer by Market Table 5-1 Emerging Therapies in Development for Ovarian Cancer Table 5-2 Estimated Launch Dates for Key Emerging Therapies for the Treatment of Ovarian Cancer Table 5-3 Select Therapies in Early-Stage Development for Ovarian Cancer Table 5-4 Select Phase III Clinical Trials Investigating Bevacizumab for Ovarian Cancer Table 6-1 Sales of Drugs to Total Ovarian Cancer (All Populations) in the Major Pharmaceutical Markets, Table 6-2 Timeline of Key Market Events for Ovarian Cancer Table 6-3 Alternative Market Scenarios for the Ovarian Cancer Market Through 2020 Table B-1 Sources for Drug Prices Table B-2 Dosing Assumptions Figure 1-1 Female Reproductive Anatomy Figure 1-2 PARP Inhibition: Figure 2-1 Crude Diagnosed Incidence and Diagnosed Incident Cases of Ovarian Cancer in the Major Markets, 2010 Figure 2-2 Trends in the Growth of Diagnosed Incident Cases of Ovarian Cancer Across the Seven Major Markets, Figure 2-3 Ovarian Cancer Patient Flow Figure 3-1 Treatment Algorithm for Early-Stage (Stage I) Ovarian Cancer Figure 3-2 Treatment Algorithm for Advanced-Stage (Stage II-IV) Ovarian Cancer Figure 4-1 Unmet Needs: Attainment and Remaining Opportunity in Ovarian Cancer Figure 6-1 Ovarian Cancer Therapies, , Market Share Figure 6-2 Sales of Major Drugs in the Ovarian Cancer Market (excluding bevacizumab), Figure 6-3 Timeline of Near-Term Events in Ovarian Cancer Figure 6-4 Distribution of the Ovarian Cancer Market Share, by Treatment Setting, Ordering: Order Online - Order by Fax - using the form below

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6 Page 1 of 2 Fax Order Form To place an order via fax simply print this form, fill in the information below and fax the completed form to (from USA) or (from Rest of World). If you have any questions please visit Order Information Please verify that the product information is correct. Product Name: Web Address: Office Code: Ovarian Cancer (Event Driven) SC Product Format Please select the product format and quantity you require: Electronic (PDF) - Single User: Quantity USD Contact Information Please enter all the information below in BLOCK CAPITALS Title: Mr Mrs Dr Miss Ms Prof First Name: Last Name: Address: * Job Title: Organisation: Address: City: Postal / Zip Code: Country: Phone Number: Fax Number: * Please refrain from using free accounts when ordering (e.g. Yahoo, Hotmail, AOL)

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