Multiple Sclerosis Treatments: World Market Outlook to 2011

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1 Brochure More information from Multiple Sclerosis Treatments: World Market Outlook to 2011 Description: Multiple sclerosis (MS) is a chronic demyelinating CNS disease that causes significant disability in young adults and others. Worldwide, millions of people are affected by multiple sclerosis. Although there is no cure, approved treatments are available to slow the progression of MS and offer improved quality of life. Kalorama Information's: Multiple Sclerosis Treatments: World Market Outlook to 2011 is one of the few publications to take a detailed look at multiple sclerosis treatment market worldwide, as well as treatments that will be available in the future. The market for these treatments has continued at double-digit growth rates, and this is expected in the near term. This report includes: A Complete Description of MS, its Causes and SymptomsComplete Incidence and Prevalence Statistics For U.S. and Worldwide. Triggers and Risk Factors of MS. Review of Multiple Sclerosis Treatments on the Market Market Size and Forecasts For Treatments to Issues and Trendsfacing MS treatment New Multiple Sclerosis Treatments in the pipeline. Kalorama Information's study focuses on the following four treatments: Copaxone Avonex Rebif Betaseron/Betaferon Additionally, the report includes products which contribute a smaller amount of sales such as Novantrone. Revenues are included for currently marketed products for each of the major pharmaceutical markets - United States, Europe, and Japan. Late stage development projects are discussed in detail with forecasts for potential revenues and anticipated approval dates. Revenues for each segment were generated using dollar and unit sales for each product. Issues and trends that are critical for the future of MS treatment are discussed in the report: Medicare and Health Insurance Issues NIH Multiple Sclerosis Funding Reduction Stem Cell Controversy and MS Access to Life-Saving Medicine Act and MS Par-3 Discovery Cyclophilin D Regulation Women and MS Pregnancy and MS Alternative Therapies in MS MS and Diabetes As part of Kalorama's trusted information -gathering process, intensive research into company, trade and medical literature was supplemented by interviews with experts in the multiple sclerosis treatment industry. Interviews make up the source of forecast and market size figures. The company profiles in this report display the diversity of products and strategies that are being explored in the multiple sclerosis market. These data were obtained from collateral material provided by the company profiled and/or through interviews with company officials. Competitors are primarily comprised of large pharmaceutical companies and biotech leaders such as Bayer Schering Pharma and Biogen IDEC. Company profiles included are: Bayer Schering Pharma AG Biogen IDEC Novartis AG Sanofi-Aventis Merck Serono S.A.

2 TEVA Contents: CHAPTER ONE: EXECUTIVE SUMMARY Introduction Scope and Methodology Size and Growth of the Market Issues an Trends Affecting Market Leading Competitors CHAPTER TWO: INTRODUCTION Introduction to Multiple Sclerosis Progression of Multiple Sclerosis Relapsing-remitting MS Primary-progressive MS Secondary-progressive MS Progressive-relapsing MS Benign MS Pathogenesis of MS Inflammatory Response and MS Triggers Risk Factors Physical Complications of MS Diagnosing MS Demographics and Statistics CHAPTER THREE: TREATMENTS FOR MULTIPLE SCLEROSIS Description of Products Copaxone Avonex Rebif Betaferon/Betaseron Tysabri Novantrone Research and Development Late Stage Development Early to Mid Stage Development Phase II Development Phase I Development Preclinical Development and Research Experimental Drugs and Treatments Discontinued Development Market and Competitive Analysis World Market Analysis World Competitive Analysis Markets by World Region U.S. Market Europe Market Japan Market CHAPTER FOUR: ISSUES AND TRENDS AFFECTING THE MS MARKET Introduction Medicare and Health Insurance Issues NIH MS Funding Reduction Stem Cell Controversy and MS Access to Life-Saving Medicine Act and MS Par-3 Discovery Cyclophilin D Regulation Women and MS Pregnancy and MS Alternative Therapies in MS Treatment MS and Diabetes

3 CHAPTER FIVE: COMPANY PROFILES Bayer Schering Pharma AG Biogen IDEC Novartis AG Sanofi-Aventis Merck Serono S.A. Teva Pharmaceutical Industries Ltd APPENDIX: COMPANY NAMES AND ADDRESSES TABLE OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY Table 1-1: Multiple Sclerosis Cases in Selected Countries. Table 1-2: The Worldwide Multiple Sclerosis Market Figure 1-1: The Worldwide Multiple Sclerosis Market CHAPTER TWO: INTRODUCTION Table 2-1: Estimated World Prevalence of Multiple Sclerosis by Selected Countries Figure 2-1: Estimated World Prevalence of Multiple Sclerosis by Selected Countries Table 2-2: World Population by Selected Geographical Region, Figure 2-2: World Population by Selected Geographical Region, Table 2-2: World Population by Selected Countries, 2006 Figure 2-3: World Population by Selected Countries, 2006 Table 2-3: Estimated World Population by Age, sex and Geographical Region, 2006 Figure 2-4: Estimated World Population by Age and Geographical Region, 2006 Figure 2-5: Estimated World Population by Sex and Geographical Region, 2006 CHAPTER THREE: TREATMENTS FOR MULTIPLE SCLEROSIS Table 3-1: Currently Available Multiple Sclerosis Treatments (Brand Name, Generic Name, Marketer and Approval Dates) Table 3-2: Estimated World Sales for Leading Products, Figure 3-1: Estimated World Sales for Leading Products, 2006 Figure 3-2: Estimated World Sales for Leading Products Figure 3-3: Estimated World Sales for Leading Products, 2006 Table 3-3: Multiple Sclerosis Products in Late Stage Development Table 3-4: Multiple Sclerosis Products in Early to Mid-Stage Development Table 3-5: The Worldwide Multiple Sclerosis Market Figure 3-4: The Worldwide Multiple Sclerosis Market Table 3-6: The Worldwide Multiple Sclerosis Market Estimated Revenues and Market Share of Leading Suppliers 2006 Figure 3-5: The Worldwide Multiple Sclerosis Market Estimated Market Share by Leading Suppliers 2001 Table 3-7: The Worldwide Multiple Sclerosis Market Projected Revenues and Market Share of Leading Suppliers 2011 Figure 3-6: The Worldwide Multiple Sclerosis Market Projected Market Share by Leading Suppliers 2011 Table 3-8: The Worldwide Multiple Sclerosis Market Estimated Products Sales by Geographic Region, Figure 3-7: The Worldwide Multiple Sclerosis Market Estimated Products Sales by Geographic Region, Figure 3-8: The Worldwide Multiple Sclerosis Market Estimated Products Sales by Geographic Region, 2004 Figure 3-9: The Worldwide Multiple Sclerosis Market Estimated Products Sales by Geographic Region, 2005 Figure 3-10: The Worldwide Multiple Sclerosis Market Estimated Products Sales by Geographic Region, 2006 Table 3-9: The U.S. Multiple Sclerosis Market Estimated Revenues and Market Share of Leading Suppliers 2006 Figure 3-13: The U.S. Multiple Sclerosis Market Projected Market Share by Leading Suppliers 2006 Table 3-10: The European Multiple Sclerosis Market Estimated Revenues and Market Share of Leading Suppliers 2006 Figure 3-14: The European Multiple Sclerosis Market Projected Market Share by Leading Suppliers 2006 Table 3-11: The Japanese Multiple Sclerosis Market Estimated Revenues and Market Share of Leading Suppliers 2006 Figure 3-15: The Japanese Multiple Sclerosis Market Projected Market Share by Leading Suppliers 2006

4 CHAPTER FOUR: ISSUES AND TRENDS AFFECTING THE MS MARKET Table 4-1: NIH Funding By Year Ordering: Order Online - Order by Fax - using the form below Order by Post - print the order form below and send to Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland.

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