HUMAN DATA IN REAL

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1 HUMAN DATA IN REAL

2

3 Body performance sometimes is a limited view

4 FROM AUTISM TO EPILEPSY Can I borrow a sensor over Christmas to see what is causing stress for my little brother - he has autism and can t talk

5 ~ years old

6 No organism is primarily adapted to be healthy, long-lived, happy, or to achieve many other goals for which people strive! We didn t evolve to be healthy, but instead we were selected to have as many offspring as possible under diverse, challenging conditions! (Daniel Lieberman, Harvard University)

7 mind engine body

8 mind Empatica E3 engine Scanadu Scout body Misfit Shine

9 where the magic happens How can we study human behavior in daily life, in a unobtrusive way, looking for insights that can benefit users?

10 Autonomic Nervous System Sympathetic Stimulation: fight or flight Parasympathetic Inhibitory: rest and digest

11 EDA AND THE BRAIN Changes in electrodermal activity occur as result of activation of regions deep in the brain

12 How Electrodermal Activity Works Human Embryo: Three tissue types Ectoderm Skin and neural tissue Endoderm Digestive and respiratory track Mesoderm Muscle and bone

13 EPILEPSY is one of the world s most common brain disorders (65M people globally)

14 Today there is no easy way to DETECT, MANAGE and ALERT for

15 OUR SOLUTION World s first SEIZURE DETECTOR DETECT MANAGE ALERT

16 Increased Seizure detection with EDA in 100% of GTCS Red lines from doctors analysis of EEG show GTCS timing Time (hr)

17 Our seizure detector has been published in Epilepsia the top epilepsy journal

18 Post-ictal Generalized EEG Suppression: important biomarker for SUDEP Seizure Period of EEG Suppression PGES was found in 7/8 monitored cases of SUDEP PGES > 80 seconds quadrupled the adjusted odds of SUDEP compared to PGES > 50 sec

19 Seizure Prediction GTCS 12 (Patient 6) 40 In some people it may be possible to detect a signal 30 preceding a seizure onset: here is a case with significant EDA peak starting 10 minutes before the 20 seizure onset (red) Time (min)

20 Medical partners and advisors: among world s top neurologists Tobi Claus Reinsberger, Orrin Devinsky, MD Joseph Madsen, MD Loddenkemper, MD MD, PhD Director NYU Director Epilepsy Boston Children s Brigham & Women s Comprehensive Surgery Program, Hospital, Winner of Hospital Epilepsy Center Boston Children s Dreifuss-Penry! Hospital Epilepsy Award 2011

21 Based on today s E3 platform: sold all over the world

22 Based on today s E3 platform: sold all over the world E3 WRISTBAND Device E3 REAL TIME Real Time Streamer CONNECT Online dashboard DATA COLLECTION REAL TIME AND OFFLINE MODES REAL TIME STREAMING BIOFEEDBACK API CLOUD REPOSITORY DATA ANALYSIS DEVICES GROUP MANAGEMENT

23 SOME DATA COLLECTION PROJECTS Sleep disorders and insomnia Addiction Hypoglycemia Affect dysregulation Alcoholism Oppositional defiant disorder Alzheimer s Pain management Anesthesia Parkinson s disease Anxiety disorder Phobias (and desensitization) Autism spectrum disorders Post-traumatic stess disorder Attention deficit hyperactivity disorder Psychiatric counseling Bipolar disorder Qadrilegia (or paraplegia) Schizophrenia Dementia Sensory processing & modulation Depression Sexual dysfunction Dysthymia Dermatology (e.g. Eczema) Sociopathy Diabetes Stroke Dialysis Temporary paralysis Drug trials Thyroid dysfunctions Endocrine disorders Epilepsy Hot flashes Cystic fibrosis

24 SOME OF OUR CLIENTS best hospitals, universities and companies in the world (100+ customers in 30+ countries) This list is not complete due to confidentiality agreements

25 Next generation device: E4

26 Epilepsy Autism PTSD Depression Anxiety Sleep disorders Stress

27

28 sensors human data analytics help

29 People couldn t care less about the data. They care about living well without complications.! What we need from wearables is insights and help, not a terabyte of raw heart rate data

30 Healing the mind also helps the body to perform much better

31

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