The skin both transmits and blocks communication
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1 Skin Physiology
2 The skin both transmits and blocks communication 1. A brief view of the anatomy 2. Sensors in the skin 3. The organ of touch 4. The language of skin 5. Barrier to the world 6. When the barrier fails
3 A model of the skin Figure by MIT OpenCourseWare.
4 Diagram removed due to copyright restrictions. A hair follicle is a cylinder of epidermal cells that have tunneled inside the dermis
5 Sensors in the skin
6 Free nerve endings (and Merkel cells): temperature, touch, pain Histology photo removed due to copyright restrictions.
7 Meissner s corpuscle lies between dermis and epidermis located in fingertips, palms, lips and tongue, nipples, genitals informs body exactly where skin is touched Histology photo removed due to copyright restrictions.
8 Histology photo removed due to copyright restrictions. Pacinian corpuscle: lies deep inside dermis; located around joints and tendons, tissue lining organs, and blood vessels. Provides instant information about how and where we move
9 The Organ of Touch
10 Buddhist monks Photo removed due to copyright restrictions. Two monks bowing to each other.
11 in France
12 Premature baby being comforted with fleece of lamb s wool at Yale University Hospital to avoid deprivation of touch Photo removed due to copyright restrictions.
13 Fire-walking ceremony in Kosti, Greece. Villagers walk on white-hot beds of coals, sometimes kneel for several minutes. Photo removed due to copyright restrictions.
14 The Language of Skin
15 Photo removed due to copyright restrictions. Human face. skin decoration used in Mt. Hagen, New Guinea
16 Photo removed due to copyright restrictions. A woman s back. Nuba woman, Sudan used special cutting tools to retard healing and form scars
17 Photo removed due to copyright restrictions. A girl s face. Meru girl, Kenya
18 Native of Amazon basin with lip disk Photo removed due to copyright restrictions.
19 Photo removed due to copyright restrictions. An actor s face being painted. Player in traditional Chinese opera
20 Hands of Moroccan woman painted for beauty and to protect during work Photo removed due to copyright restrictions. Two hands with elaborate henna design on the palms.
21 Photo removed due to copyright restrictions. A man s heavily tatoo d arm. Fourth of July celebration, New York City
22 fresh snow falling on Fuji s white crown Tago no Ura
23 a traveling actress Georges Seurat
24 A nervous itching disease possibly forced Napoleon to keep scratching
25 Natural colors and hues
26 Photo removed due to copyright restrictions. Unclothed children climbing over rocks in the bright sunlight. Melanin protects children from UV radiation in Australian outback
27 Absence of pigment (albinism) causes Hopi girl to squint, standing between her sisters Photo c
28 UV radiation levels Image removed due to copyright restrictions. Two world maps: (a) regions where UV radiation levels suffice for vitamin D synthesis throughout the year, insufficient for at least one month, and insufficient for most of the year (b) predicted skin color based on UV light levels From Jablonksi, N. G., and G. Chaplin. Skin Deep. Scientific American 287, no. 4 (Oct. 2002): Predicted skin color Scientific American
29 Barrier to the World
30 Image removed due to copyright restrictions. Thermal imaging of a child sitting on floor. Child sitting on cold floor
31 Photo courtesy of alextorrenegra on Flickr. Climbers risk frostbite when too long in contact with freezing surface
32 Skin pore, about 100 micron diameter Image removed due to copyright restrictions. Microscope photo of skin pore.
33 Sweat droplets on surface of skin. Sweat cools when allowed to evaporate from skin. Photo courtesy of Cayusa on Flickr.
34 When the Barrier Fails: Loss and Regeneration of Skin
35 Marat on July 13, Stabbed in his hot tub where he used to go often to get relief from skin disease David
36 Jesus to leper: Stand up and go your way 11 th century Echternach Gospels Lectionary
37 Photo courtesy of Mr.Mac2009 on Flickr. Trifoliate leaves of poison ivy in autumn
38 Photo removed due to copyright restrictions. Severely burned victim heals injury by contraction and scar formation
39 horses do not form large scars C. Stuart, 1997 Painting of horse removed due to copyright restrictions.
40 Photo removed due to copyright restrictions. Meshed autograft, the patient s own skin
41 MIT Artificial Skin is FDA-approved. Used in the clinic to treat massive burns and to resurface scarred skin. 1. Bilayer is grafted. 2. Silicone layer removed after 15 days, revealing new dermis. 3. Patient s epidermal graft (no dermis) covers the new dermis.
42 Conclusion: The heaviest organ also turns out to be quite complex
43 MIT OpenCourseWare J / 2.79J / 3.96J / HST.522J Biomaterials-Tissue Interactions Fall 2009 For information about citing these materials or our Terms of Use, visit:
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