Waters Empower 2 Feature Release 5

Transcription

1 R E L E A S E N O T E S Waters Empower 2 Feature Release 5 Empower 2 Feature Release 5 contains software changes, new features, and enhancements. These release notes contain the following information and instructions: New features and enhancements Problems fixed in Feature Release 5 Known issues in Feature Release 5 GxP compliance requirements Installing the buslac/e driver Removing Empower 2 Feature Release 5 Feature Release 5 program file updates Test configurations used to develop and evaluate Feature Release 5 Use these release notes in conjunction with release notes that were issued for all previous Empower service packs and feature releases. Unless superseded, all previous release note and product support information apply to this software release. Restriction: Empower 2 Feature Release 5 supports only one database instance. Therefore, do not upgrade servers that contain more than one database instance to Empower 2 Feature Release 5. See: The following guides for information on minimum system and software requirements, and for detailed instructions on installing, configuring, upgrading, and administering Empower 2 software: Empower 2 Feature Release 5 Upgrade Guide Empower 2 Installation and Configuration Guide, Revision B Requirement: Before you install Empower 2 Feature Release 5, if your Administrator-level user account contains any spaces in the name, such as rel lab, you must first add this account name to the ORA_DBA Windows User Group. (Known issue PCS 43239) Empower 2 System Administrator s Guide, Revision B Empower 2 Installation and Configuration Guide, Revision A. (Refer to this guide if you are upgrading from earlier versions of the software prior to Empower 2 Feature Release 3.) Page 1 of 32 Waters is a registered trademark of Waters Corporation. All other trademarks are the sole property of their respective owners. Copyright 2008 Waters Corporation

2 New features and enhancements Empower 2 FR5 includes the following new features and enhancements: New feature/enhancement Support for Windows Vista operating system and a new version of Oracle Microsoft Active Directory LDAP (Lightweight Directory Access Protocol) support Description Windows Vista Business Service Pack 1 Windows Vista Enterprise Service Pack 1 Oracle Enterprise Edition version Administrators can manage user accounts using either Local or LDAP authentication. Either form of authentication requires an Empower user name and password to log onto Empower, sign off results, and unlock a locked session. Waters License Management system A new Web-based license management system that provides an easy-to-use interface to register, activate, deactivate, and view licenses for Empower 2 base software and software options that you purchased. Requirement: On Windows Vista computers, you must use the new Web-based License Management utility. If you attempt to install a key disk on a Vista computer, the Program Compatibility Assistant displays a message recommending that you install using a program that is compatible with the current version of Windows. On a Windows Server 2003 or a Windows XP client, you can use either key disks or the new license management system, but not both types. On a Windows 2000 Server, you must use key disk licensing. Alternatively, you can use the new license management system on a Windows XP client or a Windows Vista client connected to the Windows 2000 Server. You can use only one type of license management system. Updated PDF file generator Compatible with Adobe Acrobat 8. Page 2 of 32

3 New feature/enhancement Empower 2 Documentation Bookshelf CD Method Validation Manager Description The new Empower 2 Documentation Bookshelf CD (Revision A) contains new and revised documentation for Empower 2 Feature Release 5, as well as existing documentation for Empower 2, in English. The System Administrator s Guide, revised for Feature Release 5, is also available in Chinese, Japanese, and Korean. As other language versions of the Empower 2 documentation become available, they will be included on this Multilanguage documentation CD. Limitation: On Vista only, when you insert the documentation bookshelf CD into the CD-ROM drive, it does not automatically run the bookshelf interface. There is a known issue with Autorun.ini files on Vista. To run the documentation bookshelf interface, navigate to the CD top-level folder, and double-click the Empower2Bookshelf.chm file. Requirement: To view the Asian language pages of the Empower 2 Documentation Bookshelf on Windows XP, you must install the Asian languages. To do so, from the Start menu, click Settings > Control Panel > Regional and Language Options > Languages tab > Install Files for Asian Languages > click OK. Various enhancements, including those listed below: Enable multiple sample preparations and injections Calculate %RF, as well as RF (Response Factor). New calculated fields in the Supportable Estimation Table for the Intermediate Precision test. New Apply Table Preferences toolbar in the Sample Set Method Editor, Run Samples, QuickStart, and Alter Samples with default preferences to filter only the fields needed for each type of method validation test. Although initially conceived for Method Validation, this capability is available to all users. Gas Chromatography enhancements New GC control parameters for the 6890-series gas chromatograph (6890A, 6890 Plus, or 6890N) See also: Instrument Method Editor > Auxiliary, Events, or Valves tab > Press F1 on your keyboard for context-sensitive Help. Empower 2 Help improvements You can now access all available Help topics from the Search tab in the Empower 2 Online Information system. To access the Empower 2 Online Information System, from any Empower Help menu, click Empower Help Topics. The application-specific Help menu items that began with the words Help on, such as Help on Configuration Manager, have been removed from the Empower Help menus, as these Help topics are now included in a new Reference section in the Page 3 of 32

4 New feature/enhancement Description Empower 2 Online Information system. System Suitability Calculation Sample plate enhancement Quick Start preferences Empower includes a new formula to calculate plate count as specified by Japanese Pharmacopoeia 15 (JP15), and retains the current plate count calculation. You can now import plate type definitions from a text file into Empower. You can now save Quick Start window preferences. Problems fixed in Feature Release 5 The following table contains a list of the software problems fixed in Feature Release 5. The PCS (Product Change System) numbers identify software issues that Waters personnel monitor within a system change request tracking tool. Problems fixed in Feature Release 5: Description Added FID and FPD Lit Offset parameters For 6890 GC instruments, the application appeared to round off the Split Ratio value calculated from the entered flow values and then adjusted the Split Flow to be consistent with the new, rounded off Split Ratio value. This was corrected by adding more digits of precision to the inlet flow parameters (to avoid round-off errors in flow) and allow a more exact value for gas flow in GC methods Batch processing did not always extract and process all channels of a method set for large sample sets with large data files. Improved memory handling fixes this issue. However, if the processing server runs out of memory while processing a large batch job, the Message Center now displays one or more memory mapping messages or messages about fetching a method, followed by this final message: Background processing job aborted due to a memory allocation failure EMD 1000 Edit method parameters and Open Access masses were not acquired properly when the method set was run using certain instruments. Updates to the XML formatting logic corrected this issue GC The purge valve switched to an off state during instrument setup. The functionality was updated so that if the valve is enabled, its position is not changed at setup unless you program a specific event GC Attempting to run a sample set with multiple injections on the same line resulted in an error message. Updates to the error handling logic corrected this issue. Page 4 of 32

5 Problems fixed in Feature Release 5: Description A maximum column precision of 14 is now available in the Component Editor Amounts columns in Alter Sample, the Default Amounts tab of the Processing Method, and in the Sample Weight and Dilution fields. Rounding was corrected in the few cases where numbers with increased precision were rounding incorrectly The View Sample Values Used in Calculations field showed multiple values. This condition no longer occurs Duplicate results for the same channel were created in a Results Set without notification. To determine whether duplicate results were superseded with newer results, add the new Results Superseded column to the Result table GC with G1512 injector controller. If the next inject delay option was not used, the instrument failed after the first injection. This has been corrected such that the use of the next inject delay option is no longer required A and 6890 Plus GC injection volume was incorrect when a nanoliter adapter was not installed. This has been corrected. To set syringe size parameters for the particular injector you are using, click the GC Sample Set Info button. See also: To run dual-tower injections on a GC instrument, the instrument required two inlets, two detectors, and two injectors. You can now use third-party injectors to run dual-tower injections on the GC instrument, but the instrument still requires two inlets and two detectors The solvent composition of an isocratic instrument method sometimes changed after saving the method. This condition no longer occurs Users who had the Alter User privilege (user account properties) could alter an account to a user type with more privileges. The list of available User Types will now only reflect User Types that have privileges equal to or a subset of those of the account that is accessing the list. A new privilege called Assign User Types to Users has been added. Users who have the Assign User Types to Users privilege can assign any user type (except Admin) to user accounts. See also: It was difficult to display the correct fields in the Sample Set Method Editor/Alter Sample for the validation test(s) to which the sample set applies. A new Apply Table Preferences toolbar enables you to display the fields required to complete a validation test. Page 5 of 32

6 Problems fixed in Feature Release 5: Description Some systems experienced Server Busy messages, MFC errors, and required LAC/E module reboots because the number of Oracle processes had been set to 150. The software now sets the minimum number of processes to 500 at installation or upgrade Empower/SDMS Restore window sometimes displayed an incorrect project list. In order to resolve this problem, a new toolkit call was added for use in a future release of SDMS In a global project, when creating a view filter for injections, channels, or results, you cannot specify a sample name condition such as =PQ* or =#. The moment you apply a newly created view filter with a condition for sample name, the sample name column disappears from the view. However, the default view filter includes the sample name column In Method Validation Manager, in the Method Validation Linearity Test, %Response Factor was not calculated. The Linearity Test now calculates the %Response Factor and %Response Factor Mean Changes to the W600 pump gradient program were not applied when it was run. Flow from a previous method version was used between injections. The software now sets the flow rate and percentages in the isocratic fields to always match the percentages in the first line of the gradient table Windows Server 2003 on a Citrix Server failed the Verify Files check, indicating that the operating system was unsupported. This has been corrected for new installations only Added a new formula for plate count calculation as specified by Japanese Pharmacopoeia 15 (JP15) while retaining current plate count calculation Sign Off 1 user was presented with a full list of reasons despite System Policy restrictions. Now, when users enter an invalid reason for Sign Off 1, they will receive the following message: This reason is not in the list of Valid Signoff 1 Reasons required to proceed with Signoff 2. Do you wish to continue with this sign off? Users must enter a valid Signoff 1 reason in order to assure a successful Signoff 2. See also: s and GC - could not select the detector makeup gas. Makeup gas types are now available for FID, FPD, NPD, and TCD. Page 6 of 32

7 Problems fixed in Feature Release 5: Description The error message Connection to chromatographic system lost, eventid 54 was caused by instrument problems that would generate an error condition that the buslac/e driver software could not handle. New buslac/e driver software is now installed to handle the error condition. A new capability is also available to report Instrument Server events into a log file, which you can activate as part of a troubleshooting process. After installing Empower 2 Feature Release 5, you must manually install the buslac/e driver. See: The section in this document entitled Installing the buslac/e driver The Summarize Custom Fields function does not work in Empower 2 as it did in Empower The Summarize Custom Fields function will continue to work as it currently does in Empower 2. The new Summarize Custom Fields Incrementally function provides the capability to summarize custom fields in the way that the Summarize Custom Fields function did in Empower These two additional functions were also added to vary the summarize custom field conditions: Summarize Custom Fields Incrementally (Exclude Faulted) Summarize Custom Fields (Exclude Faulted) Percent Recovery calculation needed more flexibility to accommodate "corrected" spike/recovery experiments. You can now set the assessed field in the accuracy test to either % Recovery (the default) or a user-created real peak custom field In Method Validation Manager, the Exceeds Threshold flag in the Filter Validation and Stability tests was being incorrectly set when a reference was used. This field now works as it should. As a result of this correction, when a reference filter is used in the Filter Validation Test, or a reference storage condition is used in the Stability Test, the values in the following fields will be calculated correctly: In the Data Table: Total Area Exceeding Threshold, Corrected %Area, Relative Peaks Exceeding Threshold, and Faulted Relative Peaks Exceeding Threshold. In the Relative Peaks Table: Corrected %Area The AutoArchive utility might crash when a project is queued and then deleted. AutoArchive now checks first to determine whether the project exists before it runs project integrity. If the project does not exist, it logs a message in the Message Center for the project The DBProject.BackupProject toolkit function failed in some cases due to an incorrect Oracle_Home setting. This issue has been corrected. Page 7 of 32

8 Problems fixed in Feature Release 5: Description In Method Validation Manager, the Accuracy Test did not allow the use of a custom field. For the Accuracy test, you can now set the assessed field to %Recovery (the default) or to a user-created real peak custom field When using expected mass, manually adjusting the end point of the last peak in a result produced an MFC error in review. This error no longer occurs In Method Validation Manager, Dilution and Sample Weight fields were not working correctly. These fields now work as they should in Method Validation calculations In Method Validation Manager, field names in the Supportable Estimation Table were unclear. The fields in the Supportable Estimation Table have been renamed The Dilution field did not input or display certain values correctly. The software now restricts the display of all double precision numbers (both user entered and calculated) to a maximum of 15 significant figures. Rounding was corrected in the few cases where numbers with increased precision were rounding incorrectly Non-Administrative users who have privileges to create and alter user accounts could not see the entire list of "Allowed User Types" (excluding the Admin user type). For users who create and alter user accounts, to view the entire list of Allowed User Types, you must have both the new privilege Assign User Types to Users and the existing privileges Alter User or Create User. See also: In Method Validation Manager, additional calculations were needed in the Supportable Estimation table of the Intermediate Precision Test. The Supportable Estimation Table now includes the fields: Total DF, Total SD LCL, Total SD UCL, Total %RSD LCL, and Total %RSD UCL The Dissolution plot overlay could be set to draw lines to the origin. This has been corrected. See also: In Method Validation Manager, the use of the term Experiment for a column name in the Supportable Estimation Table was incorrect. The table column was renamed to Points/Experiment to improve clarity In Method Validation Manager, you could not specify multiple preps and injections. Page 8 of 32

9 Problems fixed in Feature Release 5: Description Rather than having to override the red X, you can now set a checkbox in the test parameters to allow the use of both multiple preps and injections The software did not include the capability to extrapolate plot lines from the origin to the first dissolution point of a dissolution plot overlay. This capability is now provided by setting the new Line to Origin field in the Dissolution Plot properties to True. Note that the dissolution assay should be validated over the range of values plotted. See also: The capability to save layout preferences in the QuickStart User Interface was missing. This capability is now available Under certain circumstances, when using exponential notation, the Component editor might incorrectly round values. Rounding was corrected in the few cases where numbers with increased precision were rounded incorrectly A user logged on with a Guest user type was able to sign off results when this user was also assigned a user type with the privilege to sign off results. The software now grants you only those privileges assigned to the user type that you select when you log on. If you have multiple user types, such as Administrator and Guest, when you log on as Guest, you have only Guest privileges Plate definitions could be exported as a text file, but the capability to import plate definition text files into Empower was not available. You can now import plate type definition text files into Empower, so long as you have the Create Plate Type privilege When creating an instrument method with a gradient using any composition and flow rate, if you changed the flow rate within the instrument method, the software downloaded the initial condition flow rate, not the newly specified flow rate. To resolve this problem, the software sets the flow rate and percentages in the isocratic fields to always match the flow rate and percentages in the first line of the gradient table The message Unable to store Post-Run report prevented the upload of buffered data. When the size of a post-run report now exceeds 32K during buffering, the software will recover the data, but it cannot save the post-run report because it is too large. The software displays a message stating this condition Confirm ID for User Changes can be bypassed by cancelling. This condition no longer occurs. Page 9 of 32

10 Problems fixed in Feature Release 5: Description Custom Field Type" can be changed by overwriting. To resolve this issue, you cannot copy a custom field that has the same name as an existing custom field, when the two fields have different types Large batch processing of Mass Spectrometer data did not extract and process all channels of a sample set. Improved memory handling resolved this issue. Large batch processing now runs successfully Method parameters were not downloaded to an instrument if components are not enabled. This problem no longer occurs. The software sends the initial conditions to the instrument even when the column is not selected for use Free text was permitted for Sign Off 1 despite System Policy restrictions. A message now appears when signoff 1 is invalid, indicating that a valid reason for signoff 1 is required in order to complete signoff 2. See also: and Locked channels could be unlocked without requiring a comment and without requiring an audit trail message. This condition no longer occurs. All lock channel and unlock channel actions are now recorded in audit trail Under certain circumstances, Review might crash when attempting to manually add a drop line in the region of a deleted peak. This condition no longer occurs Inlet purge valve did not hold pressure of zero in Constant Pressure mode. The instrument control logic was modified so that the instrument will be left in its current state (such as off ) when both purge On Time and purge Flow Rate are set to zero When producing a summary report for bracketing with overlap, each standard from an overlapping bracket produced two results (duplicate results). This issue was fixed by adding the Include Duplicate Results checkbox on the properties for the Table report group. Select or clear this checkbox to specify whether you want to include or exclude duplicate results When User A was logged into Empower, User B with a valid user name and password was able to sign off results in User A s session. Signoff authority is now verified against the logged-in user. Page 10 of 32

11 Problems fixed in Feature Release 5: Description Toolkit: When a user other than Administrator used DBProject, an invalid privilege error was thrown on project backup. This condition no longer occurs Users sometimes experienced problems saving the archive file during an Archive and Remove Audit Trail process because a temporary audit trail table space was not deleted. This condition might have occurred when attempting to save the audit trail to a mapped drive path containing spaces in the name. Now, if you attempt to save the audit trail to a mapped drive name containing spaces, the error message that appears now clearly states that mapped drive paths cannot contain spaces, and the temporary audit trail table space will be deleted After running System Precision Signal to Noise with certain instruments, a ProcMon MFC Application Error might occur. This condition no longer occurs A and 6890Plus GC injection volume was incorrect with G1512A controller. This has been corrected. To set the syringe size parameters for the injector you are using, click the GC Sample Set Info button. See also: Percent Amount was not calculating results correctly. The Amount values used to calculate %Amount are no longer rounded to 3 decimal places prior to performing the calculation of %Amount User authentication was tracked per client instead of per user. The software now tracks authentication attempts (and failures) for each user account When modifying the default string for Signoff 1, the failed signoff was not reported until signoff 2. If a default string is modified, it must now be selected again as a valid reason for signoff. See also: and Setting a password on the Center for Empower 2 in Japanese, Chinese, or Korean prevented further access. This condition no longer occurs After installing center in Japanese, messages are garbled. Implemented the character sets and encoding for Japanese, Chinese, and Korean. Page 11 of 32

12 Problems fixed in Feature Release 5: Description Setting a password on AutoArchive Properties for Empower 2 Japanese, Chinese, or Korean prevented further access. This condition no longer occurs Method Differences did not show instrument parameters or parameter values for COM instruments. This condition no longer occurs due to Empower software; some instruments may require updated instrument drivers in order to fully show all method differences On clients connected to UNIX (Sun Solaris), the Method Validation Review Data Table did not sort by Result Id. The Data Table now sorts by Result ID on clients connected to UNIX (Sun Solaris), as it currently does on Windows platforms GPC data with an exponential skim was only shown in the chromatogram view. This condition no longer occurs. All skims are taken into account when plotting a distribution The ability to create a custom field that is the product of the peak fields in a chromatogram was missing. You can now determine the product of peak fields using the new multiplication summary function PROD that works similarly to SUM, AVG, and other summary functions The system suitability summary plot group worked correctly for peak type fields, but it did not work correctly for result type fields. This problem has been fixed as follows: The Result, Calibration, and Cal curve fields now use the Result field Channel Name to separate plots for each unique channel. Channel Name is also used as the plot title. All other fields plotted on the Y axis that apply to channels will continue to use the Chromatogram field Channel The requirement to view all Empower 2154 signoff pages could be bypassed by printing the reports. This issue no longer occurs Instrument Server would hang with rapid abort/inject selections with This issue no longer occurs The ability to suppress legends on Spectrum plot was needed. The Spectra tab in the Plot Properties dialog box includes a new checkbox called Include Channel/Spectra Description. Use this checkbox to enable/disable the display of channel/spectra descriptions. In Report Publisher, the default font size for legends has been changed to 8 point. Page 12 of 32

13 Problems fixed in Feature Release 5: Description Empower 2 displayed wrong unit label for micro-ecd GC data. This issue no longer occurs Setup error occurred when using a 6890 GC Gas Sampling valve (GSV) for injections. Empower software includes two new controls, one for each possible GSV to support GSV injection capability. A GSV injection and a tower injection cannot occur for the same injection Method Validation Manager: The Validation Test Data table showed duplicate results with multiple signoffs. This condition no longer occurs MVM - Japanese translation for Q-Factor was incorrect. Translations for Sample Preparation and Q factor have been corrected MVM - Japanese translation for buslac/e Scan was incorrect. The translation has been corrected MVM - Japanese translation for Sample Preparation. The translation was changed to match the correct translation in Feature Release 3. Online Help defects New information, enhancements, and corrections added within the Empower 2 online Help. See also: The Empower Software Cumulative Release Notes.pdf file in the root directory on the Empower 2 Feature Release 5 disk. This document contains a cumulative list of changes previously implemented in Empower 2 service packs and feature releases. Known issues in Empower 2 Feature Release 5 Known issues and workarounds: Description of known issues For Japanese, Chinese, and Korean, the Empower 2 installer does not place the 'Manage Center' shortcut on the workstation desktop (Windows XP only). Workaround: To activate notification using the Manage Center, navigate to the <drive:>\empower\bin folder, and double-click the Set Database.exe file. Page 13 of 32

14 Known issues and workarounds: Description of known issues When performing an archive and remove, a message displays: Archive Failure could not create archive file. The most likely cause is access or free space issues at the destination. When selecting Archive and Remove System Audit Trail, if you are archiving to a network location, you must use a mapped drive When viewing PDA Libraries in Configuration Manager using the following procedure, the spectra no longer appeared in the selected library: 1. Expand the Libraries tree, and then select Libraries. 2. In the Libraries list, right-click a library, and then click Open. 3. While the library is open, collapse the Library tree view, and then expand it again. 4. In the Libraries list, right-click a library, and then click Open. Result: The library appears empty (no components listed) because the value of Max Rows changed to 0. To fix this problem, change the value of Max Rows to 1000, and update the view. The spectra now appear in the library The newly implemented Wash Needle function does not work with v1.00 of the 2707 Instrument Control Software (ICS). A new version of the ICS will resolve this issue. When using Empower 2 FR5 on Windows Vista, and opening the TQD Tune page Diagnostics tab, if the information below the Vacuum, Power Supply, and RF fields is not visible on the screen and resizing the window does not correct the problem, increase your screen resolution settings until you see the entire window. The default screen resolution might not be sufficient to view the Function Details of an MS function. To increase your screen resolution settings, right-click Desktop > Properties > Settings tab, and increase the settings until you can see the entire screen. The amount values in the Component Editor for Sample Set Method History are incorrectly set to default precision. Empower 2 now saves changes for real numbers in samples, sample sets, and component amounts, when those changes increase the number past the default precision (maximum of 14 digits). However the sample history and sample set history continue to format the numbers with the default precision. Therefore, if the changes increase the number past the default precision of 14 digits, and the before and after numbers format to identical strings, the sample history states that the number was changed to the same number. Page 14 of 32

15 Known issues and workarounds: Description of known issues With Empower 2 FR5 and a ZQ instrument driver are installed on Vista Enterprise, if you configure IIS (Internet Information Services) and FTP settings using this procedure, Windows crashes: Computer Management > Services and Applications > Internet Information Services > FTP Sites > Default FTP Site. Workaround: Set up FTP and IIS (required): 1. From Control Panel, select Programs and Features, and then select the option Turn Windows Features On or Off. 2. In the Windows Features dialog box, select Internet Information Services, and turn on FTP Publishing Service, FTP Management Console, and FTP Server. 3. Under Web Management Tools, turn on ISS Management Console. 4. Accept these changes, and reboot the computer, as necessary. Configure IIS and FTP: 1. Access Computer Management > Services and Applications > Internet Information Services (IIS) Manager (not Internet Information Services IIS 6.0 Manager). 2. In the center window of IIS Manager, click the connection > FTP Sites. 3. In the right window, click the item Click here to launch. 4. In the Internet Information Services (IIS) 6.0 Manager window, expand the tree, and right-click Default FTP Site, and then click Properties. 5. In the Default FTP Site Properties dialog box, configure properties, as required On Vista SP1, when installing IIS and FTP for the ZQ or EMD mass detectors, the related FTP Service does not start automatically when you reboot the operating system, as it should. To resolve this problem, configure the FTP Publishing Service to start automatically. To do so, from Computer Management > Services, in the list of services, right-click FTP Publishing Services, and then click Properties. In the Start up Type box, select Automatic. On Windows Vista SP1, problems might be encountered when establishing communications with a ZQ or EMD detector. You must add the FTP Server to the list of Windows Firewall exceptions, and then you can reboot and successfully establish communications with the ZQ or EMD mass detectors. Page 15 of 32

16 Known issues and workarounds: Description of known issues When using Empower on a Vista computer, when you start a new application window, such as Validation Manager from the Project window, the Project window remains the active window, and the Validation Manager window opens behind the Project window. Workaround: In the Windows registry, modify the ForegroundLockTimeout registry key to be Decimal, and enter a value of 0 (Microsoft KB886217). See also: for details. When creating a project in situations when the user tablespace cannot auto extend, Empower might display the message Error copying from project xxx. When controlling an SQ, TQ, or 3100 mass detector on a workstation or acquisition client, you must install Empower 2 (typical or custom installation) on the C drive of that PC. If you install Empower 2 on a drive other than the C drive, and you start an acquisition, errors occur. Although the WebServer feature and references to it are active in Empower software, this feature is unsupported in Feature Release 5. Using either LDAP or local authentication, if a user logs into Empower and receives the message Authentication Failed, an incorrect password is the most common reason for this problem. However, in LDAP mode, authentication can also fail for any of these and other reasons: The user account was disabled or no longer exists on the LDAP server. The minimum number of password characters changed on the LDAP server. The user account underwent a department change, resulting in a change to the user s Fully Qualified Domain Name (FQDN) The Database/Import MassLynx Data option from the Empower Project window is a legacy application that is not intended for importing MS data from mass detectors, such as the SQ, TQ, and 3100 mass detectors, and other newer-model mass detectors. There are other data import capabilities available for importing more modern MS data. Page 16 of 32

17 Known issues and workarounds: Description of known issues In Method Validation Manager, the Korean translation of the word Preparations changed from Jun-bi to Si-yak. This translation change impacts following features of Method Validation: When you create a new Method Validation Manager project in Empower 2 FR5, do not copy any custom fields from a project created in a previous version of Empower 2. Doing so copies the old translation of the custom field name. If this happens, you can manually change the translation of these values in the table in the Project Properties Custom Fields tab. Although the Valid_OQMVM project contains the old translation for the Sample Preparation custom field, the OQ runs correctly. However, the name of the custom field and the custom field name that appears in the Method Validation UI will differ In Empower 2 Feature Release 5, when connecting an Empower node to a TQ mass detector for the first time, the error message An unnamed file contains an invalid path appeared. Click OK to close the message. Empower establishes communication with the instrument and the message no longer occurs. During an Empower 2 Feature Release 5 Client installation, the Windows Security Alert message Windows Firewall has blocked some features of this program might appear. Click Unblock to continue the installation. When installing Waters Service on a Windows Vista Enterprise SP1 computer, the Center registry keys were not installed correctly. When installing the Waters Service, you must log in locally as Administrator. On the program executable file, right-click, and then select Run as Administrator. In Method Validation online Help topics, the null hypothesis for Linearity Regression ANOVA and Residual Linearity ANOVA is incorrect. Correction: The null hypothesis for Regression ANOVA is that the model error is zero as compared to residual error, or the linear regression is adequate. The null hypothesis for Residual ANOVA (lack-of-fit) is that the lack-of-fit error is zero as compared to pure (random) error in replicates at each level, or the residual error is pure (random) error During the installation of Empower 2 FR5, multiple DOS windows that display information might appear, and then disappear from the desktop. When these windows display, do not press any keyboard keys or take any action in these windows. Doing so might cause the installation to pause or slow down. If you do any of these actions by mistake, press the Esc key on your keyboard. Page 17 of 32

18 Known issues and workarounds: Description of known issues When you configure a 6890 instrument using both a GSV and an injector to inject in the same position, the instrument method instructs the system to use the GSV to inject. If you used Japanese characters in the Default (name) From field in the Policies, the Japanese Center did not send any messages. To prevent this problem, in the Configuration Manager Empower System Policies dialog box, on the Policies tab, if you specify an outgoing server that does not support Chinese, Japanese, Korean, or other such characters in a normal address or alias, do not use these characters in the Default Form Name field. Otherwise, the Center might not deliver your message correctly, or it might not deliver it at all. You cannot run sample sets that specify Acquity vial position V:1 in the plate/well column. Empower displays an error message indicating an invalid plate number. In the Chinese, Japanese, and Korean versions of Empower 2, the Waters Service installation does not create the desktop shortcut correctly, using a partially translated path to Windows Desktop. During installation, the Empower 2 Client Installer does not display its progress in the Progress bar. To prevent database access problems, before you install Empower 2 Feature Release 5, if your Administrator-level account contains any spaces in the name, such as rel lab, you must add this user account name to the ORA_DBA Windows User Group. A sample set using a ZQ instrument set with the Japanese version of Empower 2 Feature Release 5 in a Windows Vista environment might not run. To resolve this problem, in Windows, modify the long date format to use the English long date format dddd, mm, dd, yyyy. The ZQ2000, ZQ4000, and EMD1000 instrument calibration will not operate properly on Windows Vista Japanese until the instrument driver can be revised. After upgrading from previous versions of Empower 2 to Empower 2 Feature Release 5, when you log into Empower 2 Feature Release 5 for the first time, the Message Center might display a warning message indicating that Oracle Error has occurred on the INVALIDPASSATTEMPT column. The Empower 2 Feature Release 5 upgrade process creates this column later in the process. This message will not occur on subsequent logins. On a Vista Enterprise 32 bit system, when installing or removing an Acquity ICOP (instrument control option pack), the progress bar indicator begins to fill, but then appears to stop, and the Wizard page also appears as though it is not responding. Do not cancel the operation because in most cases, the installation or removal process is running. Check the status bar at the bottom of the window for activity, and give the installation or removal process time to complete. Page 18 of 32

19 Known issues and workarounds: Description of known issues After performing a server upgrade, when you run the batch script file that moves the Index and Users files from the old database instance to the new database instance, if these files already exist in the new database instance, A message appears, informing you that these files already exist. When this happens, you must manually delete the Index and Users files from the new database instance, and then run the batch script file again to move the two files from the old instance to the new instance. Some topics in the online Help contain references to an incorrect book title, due to changes in the documentation set that occurred after the online Help was released. Replace all references to the Empower 2 Upgrade and Configuration Guide, Rev. B with the Empower 2 Feature Release 5 Upgrade Guide. When upgrading to FR5, during the database update, the time zone is missing from the date/time stamps of Audit Trail entries recorded before the Created Empower Node record. The time zone is also missing from the date/time stamp for the database update messages in the Message Center. When you have multiple channels in Run Samples, then use Customize Channels and deselect all of the channels, when you use the mouse to resize the channel plot area, an MFC error occurs. To avoid this problem, you must enable at least one real-time channel plot before resizing any of the plot windows in Run Samples or in QuickStart. On Windows Server 2003, firewall settings are not automatically set for the Watersservice installer. Refer to the white paper entitled "Waters Configuration Notes for Empower 2 Enterprise Server on Windows 2003 Server SP1 and R2", Revision A, dated Aug 22, The Empower 2 Online Help does not include information for specifying the minimum number of data points required to calculate any of the noise/drift results. A minimum number of 30 data points must be included in the noise interval. When examining the minimum interval necessary for data collected at 1 Hz to report an Average Peak to Peak Noise value, 30 seconds is the smallest interval that will generate a noise result. You must specify a minimum number of points to avoid biasing the apparent noise to low values by allowing the choice to result in the linear regression doing little more than "connecting the dots" within the noise interval. When using Empower 2 Feature Release 5 on a Personal configuration running Windows Vista Business with SP1 or a client configuration running Windows Vista Enterprise, the Waters DHCP Server service randomly stopped working, and displayed a message indicating that it stopped working and was closed. You can restart the service, as needed. Page 19 of 32

20 Known issues and workarounds: Description of known issues In Empower 2 Feature Release 5, when printing a report for a 6890 instrument method, the System Information report group reports incorrect values for Valve. This reporting error has no impact on the ability to acquire data nor the validity of the data acquired. If the Personal installation process fails to load the UpdateDBUtils.dll when preparing to import the exported TransportableTablesspaces, a message box appears containing the resource ID identifier and this string: W_RESTOREBACKUP_RETRY The message box should display the following information: The upgrade of your database to Empower 2 Feature Release 5 has not completed successfully. Please permit the Empower 2 FR5 installation wizard to run to completion. You will then need to uninstall Empower 2 FR5 using Add/Remove programs. Once this is complete, you will need to restore your Empower database backup into the appropriate version of Empower 2 and then upgrade to Empower 2 FR5. Windows Firewall exceptions might appear twice in the Windows Firewall Exceptions list, after installing Empower 2 FR5 and Instrument Control Option Packs (ICOP). This behavior is expected as a result of the fix for PCS 43485, which automatically enables and maintains general Windows Firewall Exceptions for Empower 2 and Ethernet instruments. Do not remove the duplicate entries, as doing so might remove the required Firewall Exceptions. In the Korean and Chinese versions of Empower 2 Feature Release 5 on a Vista Client, when background printing a result using a default report method within the Defaults project, some report fields either displayed small squares or appeared blank. Information appeared correctly in Preview/Publisher. Tip: This behavior occurred only on Empower 2 Workgroup and Enterprise. It did not occur on Empower 2 Personal. This behavior also did not occur when selecting the Report Method option Use a Report Method that is appropriate for the data. This problem happens because the report method used for "background printing" called "Default Individual Report" in the "Defaults" project uses the wrong font. Workaround: Edit the Report method and change the English font to the correct font for your language. In Empower 2 Feature Release 5, when you restore multiple files in one operation while the Confirm Identify policy is set for projects, and you cancel the Confirm Identity dialog box for one or more of those projects, the restored projects might not contain any data or audit trail information. You can delete these projects from Configuration Manager. Page 20 of 32

21 Known issues and workarounds: Description of known issues When installing instrument control software (ICS) from the Empower 2 Feature Release disk, the ICOP installation failed with an "Error - 0" error. To successfully install the ICS, on the ICOP Utility disk, navigate to the Instrument folder, and double-click setup.exe. In Empower 2 Feature Release 5 on a Citrix client, when copying and pasting a library from the Libraries view in Configuration Manager, Configuration Manager crashed. When copying a library from networked drive on the Citrix client, the message "The user must have an LDAP user DN was not found" appeared. After closing the message box, a "Copy in Progress" toolbar appeared, but nothing happened. You can import a library successfully from a Citrix client. After upgrading an Empower 2 Enterprise system to Empower 2 Feature Release 5, the Waters Licensing Wizard might display the message Invalid Option 23. This message is an artifact of the previous licensing strategy, and does not affect system operations or the validity of installed licenses. Before upgrading an Empower 2 database server (Feature Release 4 and Service Pack E) to Empower 2 Feature Release 5, used the Enterprise Edition key disk to activate the Dissolution option. After completing the upgrade, used the Waters Licensing Wizard to view the installed options. The Licensing Wizard listed the Dissolution option as an Empower Workgroup instead of Enterprise Edition. This problem is a display problem only that happens when viewing licenses in the Licensing Wizard that were previously enabled using key disks. After upgrading an Empower acquisition client computer with installed drivers for the ZQ2000, ZQ4000, EMD, and Trinity SQ, Trinity TQ, and 3100 mass detectors to Empower 2 Feature Release 5, the Waters Service automatically starts and runs. In order for the mass detectors to run correctly, you must disable the Waters Service from within Windows Services. After you disable the Waters Service, reboot both the computer and the embedded PC (EPC) in the mass detector. Page 21 of 32

22 GxP compliance requirements When you install Empower Software for the first time, or when you uninstall software, Waters recommends that you perform software qualification to meet GxP compliance requirements. Any time you install or uninstall software in a GxP environment, Waters recommends that you follow your company s management-approved software change management standard operating procedures. To assist you in making software change management decisions, refer to the section in this document that describes the program file updates contained in this feature release. To verify that the installation of this feature release does not affect any data, reprocess a data set before and after you install the software, and then verify that the results are equivalent. Waters recommends that you run either the Verify Files utility or the ConnectionsAQT for Empower IQ. After you run one of these utilities, review the resulting file for an entry that states No installation changes were detected. Installing the buslac/e driver After you install Empower 2 FR 5, install and configure the buslac/e driver. The procedure differs slightly between Windows XP and Windows Vista. Tip: If the Found New Hardware Wizard dialog appears automatically, start with step 5. If not, follow the procedures to access the Wizard manually. To install and configure the buslac/e driver on Windows XP: 1. Right-click My Computer, and then select Manage. 2. On the Computer Management page, click Computer Management (Local) > System Tools > Device Manager. In the right-hand pane, locate Other devices > PCI Device. 3. Right-click PCI Device, and then select Properties. 4. In the General tab on the PCI Device Properties page, click the Reinstall Driver button. The Found New Hardware Wizard page appears. 5. On the Found New Hardware Wizard page, select Yes, this time only and then click Next. 6. Select Install from a list or specific location (Advanced) and then click Next. 7. Select Search for the best driver in these locations and select the checkbox Include this location in the search. 8. Click the Browse button and include the following directory in the search: C:\Empower\BuslaceDrivers. 9. Click Next. Result: The BusLAC/E Driver installs. It appears as Buslace PCI KMDF Device Driver under BusLAC/E Drivers in Device Manager. Page 22 of 32