4) Study. Session. Verbalee

Size: px
Start display at page:

Download "4) Study. Session. Verbalee"

Transcription

1 4) Study Session 4.5 Progetti Giovanii Ricercatori Comitato di Valutazione Verbalee Elenco motivazioni 533

2 Ministero della Salute DIPARTIMENTO DELLA SANITA' PUBBLICA E DELL'INNOVAZIONE Direzione Generale della Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti COMITATO DI VALUTAZIONE PROGETTI GIOVANI RICERCATORI BANDO RF (ex D.M. 4 dicembre 2013) VERBALE STUDY SESSION 19 e 20 DICEMBRE

3 I giorni 19 e 20 dicembre 2013 alle ore 9,00, presso la Stanza A325 del Ministero della Salute, sito in Roma in Via Giorgio Ribotta, 5, si è riunito il Comitato di Valutazione per i progetti giovani ricercatori, afferenti al Bando R.F , nella composizione di cui al D.M. 4 dicembre Partecipano i componenti di seguito riportati: Dott. Amedeo ANSELMI Dott.ssa Maria Domenica CASTELLONE Dott.ssa Bruna CORRADETTI Dott.ssa Chiara GABBI (Presidente) Dott.ssa Cristina Costanza Giovanna GERVASINI Dott. Giovanni LI VOLTI Dott. Francesco RICCI Dott. Aldo Maria ROCCARO Dott.ssa Francesca TARABALLI La Dott.ssa Mariangela CHISARI risulta assente giustificata, a seguito della comunicazione di sopraggiunte impossibilità alla partecipazione pervenuta via mail in data 11 dicembre u.s. (All.1). Il Dott. Massimo Casciello, Direttore Generale della Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti, porge il benvenuto ai presenti e comunica che la conduzione della study session sarà affidata alla Dott.ssa Chiara Gabbi in qualità di Presidente del Comitato di che trattasi, al Dott. Gaetano Gugliemi, direttore dell Ufficio III in qualità di referente del processo di valutazione e alla Dott.ssa Maria Novella Luciani, Direttore dell Ufficio IV, referente per i dettagli organizzativi e per i rapporti nella fase audit con la Commissione Nazionale per la Ricerca Sanitaria. Gugliemi, nel salutare i componenti specifica le procedure di assegnazione e di valutazione effettuate dai referees per i progetti Giovani Ricercatori presentati nel Bando Ricerca Finalizzata , puntualizzando che i progetti presentati in questa sezione sono in totale 1218 (All. n. 2) di cui 3 con una sola valutazione e 283 con due valutazioni ma senza F2F (face to face) concluso. Comunica, preliminarmente, le procedure da seguire nel corso della study session e, presentata ai componenti la situazione del referaggio effettuato, espone le modalità di accesso al sistema, per le quali sono attribuite a ciascun membro le proprie credenziali informatiche. Rappresenta, inoltre, che per la prima volta è stato attivato un sistema di Editors che ha controllato la corrispondenza dei punteggi dati, in rispetto alle linee guida e che eventuali non corrispondenze saranno indicate alla study session attraverso una specifica segnalazione nel cruscotto di valutazione. 2

4 La Dott.ssa Chiara Gabbi dà avvio alla discussione per la definizione collegiale dei criteri da seguire nel corso dei lavori. Il Comitato prende quindi atto che i progetti - GR ; - GR ; - GR ; - GR ; - GR sono stati posti in valutazione in via cautelativa e che la decisione finale sul rispetto dei requisiti amministrativi previsti dal Bando è di competenza della Commissione Nazionale Ricerca Sanitaria. Il Comitato assegna, poi, i seguenti progetti con una sola valutazione, affinché al termine possa risultare che tutti i progetti abbiano due valutazioni individuali e indipendenti: - GR ; - GR ; - GR I commissari, dopo aver esaminato i progetti con un solo giudizio, avviano un ampia discussione collegiale al fine di condividere il punteggio finale da assegnare. Il Comitato, successivamente, passa all esame dei progetti primariamente con due valutazioni senza face to face concluso (All. n. 3). Il Comitato decide, altresì, di rivedere tra tali progetti con particolare attenzione quelli con entrambi i giudizi con un delta superiore a 5. Alle ore 12 del 19 dicembre 2013, il Ministro porge i saluti e augura buon lavoro ai partecipanti, ringraziandoli della fattiva collaborazione e sottolineando l importanza e l eccellenza dell attività di ricerca svolta anche all estero dai giovani ricercatori italiani. I lavori vengono sospesi alle ore 19,00 del 19 dicembre 2013 e riprendono alle ore 09,00 del 20 dicembre Il Comitato procede quindi alla rivalutazione di n. 6 progetti il cui giudizio del face to face risulta sospeso perché rifiutato da uno dei due referee. Si tratta dei seguenti progetti: - GR GR GR GR GR GR

5 Concluse tutte le fasi di valutazione viene visualizzata la situazione completa di tutti i progetti. Dopo ulteriore verifica della coerenza del giudizio espresso dai referee sia nelle valutazioni individuali che nel face to face con il punteggio attribuito, il Comitato di Valutazione Giovani Ricercatori collegialmente procede alla stesura dei relativi commenti di valutazione (All. n. 4) e alla stesura della graduatoria finale, approvandola, come da elenco allegato al presente verbale come parte integrante dello stesso (All. n. 5). Il Comitato suggerisce quindi, tenuto conto dell elevata qualità scientifica dei progetti presentati, di proporre alla Commissione Nazionale per la Ricerca Sanitaria di assicurare il finanziamento di tutti i progetti con un final score pari a 12 eventualmente anche attraverso una riduzione economica che, comunque, non infici la loro realizzazione. Il Presidente chiude i lavori della study session del Comitato di Valutazione dei progetti Giovani Ricercatori alle ore 18,00 del 20 dicembre Roma, 20 dicembre 2013 IL PRESIDENTE Dott.ssa Chiara Gabbi F.to GABBI I COMPONENTI: Dott. Amedeo ANSELMI F.to ANSELMI Dott.ssa Maria Domenica CASTELLONE F.to CASTELLONE Dott.ssa Mariangela CHISARI ASSENTE GIUSTIFICATA_ Dott.ssa Bruna CORRADETTI _F.to CORRADETTI_ Dott.ssa Cristina Costanza Giovanna GERVASINI F.to GERVASINI Dott. Giovanni LI VOLTI _F.to LI VOLTI Dott. Francesco RICCI _F.to RICCI Dott. Aldo Maria ROCCARO _F.to ROCCARO Dott.ssa Francesca TARABALLI _F.to TARABALLI 4

6 BANDO RICERCA FINALIZZATA-GIOVANI RICERCATORI COMITATO VALUTAZIONE GIOVANI RICERCATORI Elenco Motivazioni GR IDENTIFICATION OF NEW GENES FOR RARE NEURODEVELOPMENTAL DISORDERS BY HOMOZIGOSITY MAPPING/NEXT GENERATION SEQUENCING AND FUNCTIONAL STUDIES IN ZEBRAFISH This project focuses on use of a multimethod approach to discover novel causative genes in neurodevelopmental disorders. The topic is relevant to National Health System and appears feasible. The methodology includes homozigosity mapping, NGS and Zebrafish model. Beside the limited originality to use NGS to identify novel responsible genes, the impact of the outcome make the study a potentially important project. The rationale is well defined, the facilities and the budget are adequate. Strenghts include the preliminary data, focusing on a similar exploratory-study, and the adequate profile of the PI and his team/collaborators (UO1 and UO2). Weakness include the poor information about the specific selection of families to be enrolled in the study. The impact of the identification of novel genes responsible of neurodevelopmental disorders could be important for a better diagnosis and therapeutic approach in the future. After reviewing the scores and the comments of both the reviewers, the committe agree with the score of reviewer 2 and agree with a final score of 10. Final Score: 10 GR Role of type I IFN in dictating the immunogenicity and therapeutic efficacy of chemotherapy: from animal models to humans The objective of the present proposal is to investigate whether the immunogenic potential and, consequently, the therapeutic success of defined chemotherapeutic drugs resides in the early induction of type I IFN within tumor bed and to elucidate the underlying molecular mechanisms. The PI has a very good publication track record and exceptional collaborators. Istituto Superiore di Sanità is an outstanding environment for the proposed studies. Budget is appropriate. After reading the scores and the comments of the reviewers, the committee agrees with the final score of Final Score: 14,

7 GR Contrast enhanced ultrasound (CEUS) in neurosurgery: characterization of brain gliomas and role in tumor resection After reviewing the scores of the reviewers, the committe agree with the proposed final score of the F2F Final Score: 21,5 GR Pleiotropic transcriptional control mechanisms of CD49d expression in trisomy 12 chronic lymphocytic leukemia: implications for novel therapeutic approaches scores. Final Score: 11,75 GR Towards the prediction of dyslipidemia from next generation sequencing data This study aims to establish a novel diagnostic protocol for the prediction of dyslipidemia from genetic predispositions. The proposal is of high scientific quality. The team members are appropriate in terms of availability and complementarities of all the relevant expertise, and in how the different roles and responsibilities are distinguished. The applicant is well established in the field. Budget is adequate. The committee proposes a final score of Final Score: 10 GR Identification of new biomarkers to monitor cardiovascular (CV) and renal events in Type 2 diabetic patients and evaluation of the specific role of the gut microbiome scores. Final Score: 14,

8 GR Role of neutrophils in atherosclerotic plaque development and progression: friends or foes? After reading the scores and the comments of the Reviewers, the Committee agrees with the final score of 16.5 issued from the face-to-face forum. Final Score: 16,5 GR Cerebral Amyloid Angiopathy related inflammation as a human spontaneous model of amyloidrelated imaging abnormalities (ARIA): identification of new biomarkers for patients stratification and follow up in Aß disease modifying therapies scores. Final Score: 13,25 GR CHEMOPREVENTION AND PRE CANCEROUS LESIONS: DEVELOPING BIOMARKERS TO MONITOR DIETARY MODIFICATIONS FOR THE PREVENTION OF CERVICAL CANCER scores. Final Score: 16,25 GR Indoleamine 2,3 Dioxygenase and Peripheral Tolerance to Exogenous Factor VIII: a Multi Centre Study scores. Final Score: 12,75 GR AUTOPHAGY CONTRIBUTION TO BREAST CANCER STEM CELLS BEHAVIOUR scores. Final Score: 13,

9 GR Inflammatory pathways in acute myeloid leukemia: a role for ATP in helping eradicate leukemic stem cells scores. Final Score: 21,25 GR Non coding RNA mediated control of human regulatory T cell development, function, and stability in health and disease. After reading the scores and comments of the reviewers the commettee agrees with the proposed F2F score. Final Score: 11 GR Use of flavonoids contained in Flavocoxid to reduce vascular damage in an experimental model of atherosclerosis scores. Final Score: 7 GR HLA G as Prognostic Marker for Cytomegalovirus Infection and Clinically Relevant Heart Allograft Outcomes scores. Final Score: 10,5 GR A combination of mir501 5p and mtor as molecular markers for the prognosis of renal carcinomas Status F2F: Confirmed the scientif panel agrees with review #1 bout the over extimation of the budget Final Score: 12,

10 GR Targeting inflammation in atherosclerosis: role and therapeutic potential of sphingosine 1 phosphate (S1P) and its receptors scores. Final Score: 9,75 GR Cardiac Stromal Cells as a model of Arrhythmogenic Right Ventricular Dysplasia scores. Final Score: 18,25 GR Exploring the role of macrophages in physiological bone healing and their potential for innovative bone regeneration therapies. Status F2F: Confirmed The commitee reviewed the F2F assessments and elaborated the final scores being more consistent with the guidelines. The scores assigned by the reviewer #1 do not match the comments. Many criticisms have been noticed, mainly regarding preliminary dataand methodologies. The overall hypothesis is not clear, affecting the scientific quality of the study. Therefore, the committee has decided to validate the average between the scores. Final Score: 13 GR Periventricular Heterotopia: identification of new causative genes through massive parallel sequencing and RNA interference. Delta score is high because both reviewers have used high scores, making the difference to look higher. Nonetheless comments are similar and there are no anomalies therefore committee agrees on the average score. Final Score:

11 GR Regulation of the linear ubiquitin chain assembly complex by IAPs in the metastasization process of cancer cells scores. Final Score: 14,75 GR An integrated approach to clonal mast cell disorders scores. Final Score: 15 GR Uncovering hematopoietic stem cell clonal dynamics in humans by retroviral tagging Status F2F: Rejected The applicant aims to study the hematopoietic system at clonal levels in humans exploiting integration sites databases generated from gene therapy trials and from in vitro and in vivo models of human hematopoiesis. Although the reviewers agree, they use different scores, which for some extend do not match with the comments. After reviewing the proposal and the comments of the reviewers, the committee confirms the average between the two comments. Final score of Final Score: 14,25 GR Iron depletion approach for the resolution of the HCV induced steatohepatitis: development of new therapeutic strategy scores. Final Score: 15,

12 GR Insulin resistance, bile acid profile and diet in the development of esophageal adenocarcinoma in patients with Barrett's Esophagus. After reading the scores and comments of the reviewers the commettee agrees with the proposed F2F score. Final Score: 24 GR On the road again. Evaluation of the procedures helping patients to return to drive after Traumatic Brain Injury and testing of a new rehabilitation protocol scores. Final Score: 22,25 GR Clinical, genetic and neuroimaging profiles in Italian patients with Fronto Temporal Dementia scores. Final Score: 11,25 GR Proof of concept studies of SIRT6 inhibitors for treating type II diabetes scores. Final Score: 11,5 GR Dysexecutive syndrome and visuo spatial dysfunction as risk factors for postural instability and frequent falls in patients with dementia and parkinsonism: from early diagnosis to rehabilitation strategies. The scientific panel after careful evaluation of reviewers' comments agrees on the average score as final Final Score:

13 GR Functional analysis of SCN1A mutations with ips cell derived human neurons: assay for clarifying genotype phenotype correlations and develop targeted therapeutic approaches. scores. Final Score: 27,5 GR Unraveling the genetic complexity of myeloproliferative neoplasms and the molecular pathways involved in disease progression The present proposal aims to perform whole-exome sequencing to identify mutations in Jack-, Mpl-, normal karyotype MPN samples. The studies may lead to the identification of novel mutations that contribute to progression to AML. Overall the proposal has been well written. Nevertheless, two major concerns have been raised. First, it is not clear whether the Applicant will be able to reach a significant number of samples that may support any statistic significance. Second, the idea of performing whole exome sequencing may be a limitating factor, since putative relevant mutations may occur in noncoding regions. The PI responsible for the submitted proposal has expertise in the specific field, as documented by the publication in medium-impact factor Journals. The Institution is adequate for completing the proposed studies. The Committee has agreed on a final score of 13.5, as in the proposed F2F score. Final Score: 13,5 GR BASAL GANGLIA FUNCTIONAL ABNORMALITIES CORRELATING WITH GAIT DISTURBANCES IN PARKINSON'S DISEASE. TOWARD NOVEL BRAIN SIGNAL CONTROLLED DEVICES FOR ADAPTIVE DEEP BRAIN STIMULATION. The present study aims to develop deep brain stimulation (DBS) patterns to prevent and inhibit freezing of gait (FOG), which is one of the major disturbances in Parkinson s Diseases. The applicant should clarify what is meant by adapting DBS to moment to moment clinical states. If successful, the proposal could eventually contribute to improvements in the efficacy of DBS in reducing freezing of gait and improving outcomes in Parkinson's disease patients. The proposal is well written and has logical aims. The novelty of the study relies in the development of a system that is responsive to freezing of gait. Facilities and infrastructure are appropriate for the proposed studies. Budget is also appropriate. The applicant is a young investigator at the first year of the PhD training. She is first author in several publications related to the topic of the proposal. Complementary expertise will be provided by the assembled team. Despite the high potential of the candidate to 720 8

14 develop an independent career, this reviewer has concerns regarding the leadership of the candidate and the feasibility of the proposed study. After reading the scores and the comments of the reviewers, the committee agrees with the final score of 16. Final Score: 16 GR Interactions of genotype, phenotype, local immune system and microbiologic environment in the pathogenesis of Hirschsprung's disease associated enterocolitis scores. Final Score: 10 GR Development of a carbon nanotube DNA microarray for rapid detection of antibiotic resistant genes in pathogenic bacteria After reading the scores and comments of the two reviewers the commette consider to accept the averaged score Final Score: 15,75 GR Development and validation of novel methods for the in vivo assessment of distinct patterns of connectivity in the disorders of consciousness scores. Final Score: 10,25 GR EVALUATION OF ANTIBIOTIC PRESCRIPTION PROFILES IN CHILDREN AND THEIR PARENTS scores. Final Score: 29,

15 GR PRESERVATION OF THE REPRODUCTIVE FUNCTION IN ONCOLOGICAL CHILDREN AND WOMEN AT RISK OF PREMATURE OVARIAN FAILURE: OPTIMIZATION OF OVARIAN TISSUE CRYOPRESERVATION scores. Final Score: 19 GR Prospective study on the potential use of Neuropeptides as biomarkers of disease severity and response to treatment in allergic patients. scores. Final Score: 24,25 GR Intellectual developmental disorders in Friuli Venezia Giulia Region, Italy: prevalence, burden of disease, pathways of care, services and sources of information. TL clearly has not read the project! The general idea of studying prevalence of intellectual developmental disorders in 0-17 years old children can be interesting but the methodologies and aims are unclear. Applicant has a good CV and publication records but not the same for co-workers. The committee proposes to accept the evaluation of the second reviewer. Final Score: 21 GR An integrated biomolecular, neuroradiological, and clinical study to investigate brain development, onset and progression in Huntington s disease scores. Final Score: 15,

16 GR Genome wide screening in patients with Ruptured and Unruptured Intracranial Aneurysm: a pilot study to identify genetic variants associated with risk of aneurysm rupture. scores. Final Score: 14 GR Rib like chest wall reconstruction after wide thoracectomy because of cancer: how much does the change of the thoracic elastance impair the postoperative respiratory function? A prospective, observational clinical study. scores. Final Score: 24 GR Phase 2, open label, multicenter, randomized study of PD (oral CDK 4/6 inhibitor) monotherapy and PD in combination with the endocrine therapy to which the patient has progressed in the previous line for ER positive, HER2 negative post men After reading the scores and comments of the two reviewers the commette consider to accept the averaged score Final Score: 17,75 GR Multi biomarker prediction of response to methotrexate in early Rheumatoid Arthritis scores. Final Score: 13,

17 GR Development of an engineered human ipscs derived bio pacemaker as an in vitro platform for drug screening This is a potentially interesting proposal that aims to verify the feasibility of in vitro generating human ipsc-derived engineered bio-pacemakers and their suitability as platforms for drug screening in order to test cardiotoxicity or proarrhythmic actions. Nevertheless, the overall interest is lowered by the lack of clarity in regards to the working methodologies and experimental procedures that appears to be not well focused, nor well described. The PI responsible for the submitted proposal is a Young Investigator that has shown proven to be a promising researcher as documented by the relative track of publications listed within the application. The Committee has agreed on a final score of Final Score: 17,5 GR Hospitalization and comorbidities in patients with parkinsonism and / or dementia: a study of prevalence and management proposals scores. Final Score: 22 GR Guidelines for the identification of quality standards for the realization of extra hospital structures for subjects in Vegetative or Minimally Conscious State The two Reviewers were concordant about the limitations of the publication background of the PI. The possibility to recruit a sufficient number of cases to run a reliable analysis for the construction of national guidelines remains questionable. After reading the scores and the comments of the Reviewers, the Committee accepts the proposed score issued from the face-to-face agreement of 23. Final Score: 23 GR Genetic basis of steroid resistant nephrotic syndrome and implications for therapy Status F2F: Rejected After reviewing the scores and the comments of the reviewers, the committe agree with the average final score of 12,5. The expertise of the applicant in the field is very good but the publications record (excellent for one paper) is limited. The project is ambitious and it is not well hypothesis driven, as indicated by the reviewer 2. Final Score: 12,

18 GR Role of micrornas in modulating platelet function in patients with acute coronary syndromes. the evaluation board agrees on accepting as final the aproposed F2F assesment Final Score: 11,5 GR Melanopsin retinal ganglion cells and circadian photoentrainment in Alzheimer's disease, Down syndrome and aging After reading the scores and the comments of the reviewers, the committee agreed with the score proposed by the reviewers in the advanced F2F forum. Final Score: 20 GR Early prediction of outcome in comatose patients with severe traumatic brain injury: evaluation of brain activity with 18F FDG PET scores. Final Score: 17,5 GR Impulse control disorders in Parkinson s disease. A neurophysiological study of cortical inhibitory mechanisms, functional connectivity, and volitional control of actions scores. Final Score: 28,

19 GR Testing the competition for c Kit ligand between mast cells and stem cells: implications for treatment with tyrosine kinase inhibitors in prostate cancer After reading the scores and comments of the two reviewers the commette consider to accept the averaged score Final Score: 14,75 GR IFNgamma as a potential therapeutic target in secondary HLH scores. Final Score: 12,5 GR Human Cerenko mammo tomography using beta emitting radiopharmaceuticals scores. Final Score: 13,5 GR Imaging of bone marrow sympathetic innervation. After reading the scores and the comments of the reviewers, the committee agreed with the final proposed F2F score Final Score: 19 GR The impact of aerobic exercise on cytokine production in patients with multiple sclerosis. The two Reviewers agreed over the scientific quality of this application, and were finally concordant over the validity of methodology, novelty and merits of the applicant. Therefore, after reading the scores and the comments of the Reviewers, the Committee accepts the proposed score issued from the face-to-face agreement of 15. Final Score:

20 GR Insights into the molecular mechanisms of Anorexia Nervosa Although delta score is high there are no anomalies in the comments and the committee agrees on a score which represents the mean of the two scores. Final Score: 20,75 GR GRADE Dispute. Improving appropriateness and transparency of processes to develop guidelines on controversial clinical areas: evidence, values and context preferences to help mitigate disputes and enhance the applicability of recommendations to practice. scores. Final Score: 10 GR Preclinical optimization of treatment with inhaled argon to improve neurological outcome and survival after cardiac arrest scores. Final Score: 9,75 GR Mineral metabolism and microvascular function in patients with chronic kidney disease This proposal aims to investigate the role of 1,25dihydroxyvitamin D (1,25(OH)D) and Parathyroid Hormone in the pathogenesis of cardiovascular events in patients with chronic kidney insufficiency. Although this project has interesting ideas, the study design is extremely weak. For instance, patients have to be stratified according to the different etiologies of the renal disease as well as to other independent cardiovascular risk factors. Therefore a sample size of 20 appears to be insufficient to reach a significant statistical power. PI is MD, resident in nuclear medicine, with only 1 paper in the same field of the proposal. No senior authorships, raising the concern on the effective leaderships in this proposal. After reviewing the scores and the assessments of the reviewers, the commission agrees with the final score of Final Score: 21,

21 GR Age induced reduction of neurogenesis induces functional alterations of the blood brain barrier contributing to the detrimental outcome of stroke in the elderly. scores. Final Score: 10 GR Role of the combined ultrasonographic imaging and neurophysiological study for surgical treatment of peripheral nerves pathologies scores. Final Score: 21,75 GR Human liver steatosis: potential mechanisms linking lipogenic enzymes, gut peptides and intestinal permeability The Committee has evaluated the scores provided by the two Reviewers. The working methodology has not been properly defined. The proposal lacks of complete novelty. Both Reviewers have properly discussed and addressed all their concern and the Committee has agreed on the final score of 21, as proposed in the F2F evaluation. Final Score: 21 GR Electrophysiological, behavioural and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinson s Disease with Dementia scores. Final Score: 10,

22 GR Toward identification of biomarkers in patients with irritable bowel syndrome (IBS) scores. Final Score: 19,75 GR Can default and attentional network dysfunctions lead to Visual Hallucinations and Delusions in Lewy body disease? This project aims to investigate the aetiology of visual hallucinations (VH) in Lewy body diseases (LBD) using an original combined MRI/fMRI/DTI/MRS methodology. The proposal was evaluated by two reviewers. Both reviewers found that the proposal presents good resources and facilities. They also found the project innovative and well written. One of the reviewer found in the proposal some weaknesses that include the unclear role of the units for some aim and the uncertainity of the therapeutic outcome. The committee agrees that these weaknesses limit the impact of the proposal and also notes that the proposal might benefit from more experienced collaborators, more articles as first-author of the applicant and a clearer evaluation of the study design in the proposal. For the above reasons the committee suggests a final score of Final Score: 14 GR Association between an increased systemic inflamation level in periodontitis and cardiovascular diseases: a randomized protocol. After reviewing the scores and the assessments of the reviewers, the commission agrees with the final score of 32. Final Score:

23 GR Molecular and functional characterization of an HDAC regulated mir network that controls the composition of the chromatin remodeling complex muscle regeneration versus fibro adipogenic degeneration in neuromuscular disorders The aim of this proposal is to investigate the molecular mechanism behind the beneficial role of HDACs inhibitors in muscle regeneration. The rationale and hypothesis of the project are not clear. The proposal needs to be widely amended pointing out the strengths and weaknesses of the proposed strategy, defining relevant specific aims and describing the methodology more specifically (i.e. how the RNAseq data will be generated?), as well as discussing the impact in translation. After reading the scores and the comments of the reviewers, the committee agrees with the final score of Final Score: 20,5 GR NOVEL BIOMARKERS IN MALIGNANT PLEURAL MESOTHELIOMA: FROM MOLECULAR PREDICTORS OF RESPONSE TO THERAPY TO NOVEL MULTIMODAL THERAPEUTIC STRATEGIES Status F2F: Rejected It emerges from the face-to-face forum that the two Reviewers were actually concordant over the final score to be attributed. Therefore, after reading the scores and the comments of the Reviewers, the Committee agrees to accept the proposed score issued from the face-to-face forum of 11. Final Score: 11 GR In vivo and ex vivo translational study of the effect of Metformin on brain metabolism: implication for Alzheimer's disease pathophysiology scores. Final Score: 13 GR Deep Brain Stimulation and EEG fmri for drug resistant epilepsies: assessment of the role of subcortical brain structures in the neuro modulation of epileptic networks. scores. Final Score: 17,

RICERCA FINALIZZATA+GIOVANI RICERCATORI MALATTIE RARE. Graduatoria e Finanziamento

RICERCA FINALIZZATA+GIOVANI RICERCATORI MALATTIE RARE. Graduatoria e Finanziamento Direzione Generale Ricerca Scientifica e Tecnologica RICERCA FINALIZZATA+GIOVANI RICERCATORI MALATTIE RARE Graduatoria e Finanziamento Ministero della Salute Direzione Generale Ricerca Scientifica e Tecnologica

More information

Gene Therapy. The use of DNA as a drug. Edited by Gavin Brooks. BPharm, PhD, MRPharmS (PP) Pharmaceutical Press

Gene Therapy. The use of DNA as a drug. Edited by Gavin Brooks. BPharm, PhD, MRPharmS (PP) Pharmaceutical Press Gene Therapy The use of DNA as a drug Edited by Gavin Brooks BPharm, PhD, MRPharmS (PP) Pharmaceutical Press Contents Preface xiii Acknowledgements xv About the editor xvi Contributors xvii An introduction

More information

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle TITLE PROJET NOM HOPITAL Assessment of tumor angiogenesis using PET/CT with 18 F-Galacto- RGD. (PNC_29_001) Division of

More information

Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine

Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine January 27, 2009 Dear Professors (representative) of departments, Subject:

More information

National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook

National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook National MS Society Information Sourcebook www.nationalmssociety.org/sourcebook Chemotherapy The literal meaning of the term chemotherapy is to treat with a chemical agent, but the term generally refers

More information

Autoimmunity and immunemediated. FOCiS. Lecture outline

Autoimmunity and immunemediated. FOCiS. Lecture outline 1 Autoimmunity and immunemediated inflammatory diseases Abul K. Abbas, MD UCSF FOCiS 2 Lecture outline Pathogenesis of autoimmunity: why selftolerance fails Genetics of autoimmune diseases Therapeutic

More information

STEM CELL FELLOWSHIP

STEM CELL FELLOWSHIP Module I: The Basic Principles of Stem Cells 1. Basics of Stem Cells a. Understanding the development of embryonic stem cells i. Embryonic stem cells ii. Embryonic germ cells iii. Differentiated stem cell

More information

Management in the pre-hospital setting

Management in the pre-hospital setting Management in the pre-hospital setting Inflammation of the joints Two main types: Osteoarthritis - cartilage loss from wear and tear Rheumatoid arthritis - autoimmune disorder Affects all age groups,

More information

A Genetic Analysis of Rheumatoid Arthritis

A Genetic Analysis of Rheumatoid Arthritis A Genetic Analysis of Rheumatoid Arthritis Introduction to Rheumatoid Arthritis: Classification and Diagnosis Rheumatoid arthritis is a chronic inflammatory disorder that affects mainly synovial joints.

More information

J D R F R E Q U E S T S L E T T E R S O F I N T E N T F O R : B I O M AR K E R S O F P AN C R E A T I C B E T A C E L L S T R E S S AN D H E AL T H

J D R F R E Q U E S T S L E T T E R S O F I N T E N T F O R : B I O M AR K E R S O F P AN C R E A T I C B E T A C E L L S T R E S S AN D H E AL T H J D R F R E Q U E S T S L E T T E R S O F I N T E N T F O R : B I O M AR K E R S O F P AN C R E A T I C B E T A C E L L S T R E S S AN D H E AL T H PURPOSE JDRF, the world s leading non-profit organization

More information

The Types of stem cells: Totipotent Pluripotent Multipotent

The Types of stem cells: Totipotent Pluripotent Multipotent Stem Cells is the main material for building and regeneration of the body Stem cells are not differentiated and can transform to any cell of organism Stem cells are capable of indefinite renewal through

More information

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Genomic Medicine The Future of Cancer Care Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Personalized Medicine Personalized health care is a broad term for interventions

More information

your complete stem cell bank

your complete stem cell bank your complete stem cell bank HYDERABAD - 88985 000 888, WARANGAL - 8297 256 777 VISAKHAPATNAM - 7799 990 774 VIJAYAWADA AND GUNTUR - 7799 990 771 NELLORE - 7799 990 772, KADAPA - 8297 256 700 RAJAHMUNDRY

More information

5 Frequently Asked Questions About Adult Stem Cell Research

5 Frequently Asked Questions About Adult Stem Cell Research 5 Frequently Asked Questions About Adult Stem Cell Research Stem cells are often referred to in the sociopolitical realm with some level of controversy and beyond that, some level of confusion. Many researchers

More information

If you were diagnosed with cancer today, what would your chances of survival be?

If you were diagnosed with cancer today, what would your chances of survival be? Q.1 If you were diagnosed with cancer today, what would your chances of survival be? Ongoing medical research from the last two decades has seen the cancer survival rate increase by more than 40%. However

More information

JUMISC JUMISC. For further information visit our website:

JUMISC JUMISC. For further information visit our website: STEM CELL THERAPY COMPANY PROFILE & SCIENTIFIC ACTIVITIES For further information visit our website: WWW.CCMIJESUSUSON.COM 20 14 JUMISC JUMISC Carretera N-521, km. 41,8 10071 CÁCERES (SPAIN) Tel. (+34)

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

Roche Position on Human Stem Cells

Roche Position on Human Stem Cells Roche Position on Human Stem Cells Background Stem cells and treating diseases. Stem cells and their applications offer an enormous potential for the treatment and even the cure of diseases, along with

More information

Why study clinical neuropsychology?

Why study clinical neuropsychology? University Leiden, The Netherlands Master (MSc) in Clinical Neuropsychology H.A.M.Middelkoop@lumc.nl www.neuropsychologie.leidenuniv.nl Why study clinical neuropsychology? You are interested in: brain/behavior

More information

2014 Neurologic Physical Therapy Professional Education Consortium Webinar Course Descriptions and Objectives

2014 Neurologic Physical Therapy Professional Education Consortium Webinar Course Descriptions and Objectives Descriptions and Neuroplasticity Health care providers are facing greater time restrictions to render services to the individual with neurological dysfunction. However, the scientific community has recognized

More information

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials

LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT emerging treatments Presentation for: Judith E. Karp, MD Advancements for Acute Myelogenous Leukemia Supported by an unrestricted educational

More information

OHTAC Recommendation

OHTAC Recommendation OHTAC Recommendation Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency Presented to the Ontario Health Technology Advisory Committee in May 2010 May 2010 Issue Background A review on the

More information

INTRODUCTION Thrombophilia deep vein thrombosis DVT pulmonary embolism PE inherited thrombophilia

INTRODUCTION Thrombophilia deep vein thrombosis DVT pulmonary embolism PE inherited thrombophilia INTRODUCTION Thrombophilia (Hypercoagulability) is a condition in which a person forms blood clots more than normal. Blood clots may occur in the arms or legs (e.g., deep vein thrombosis DVT), the lungs

More information

Overview of Phase 1 Oncology Trials of Biologic Therapeutics

Overview of Phase 1 Oncology Trials of Biologic Therapeutics Overview of Phase 1 Oncology Trials of Biologic Therapeutics Susan Jerian, MD ONCORD, Inc. February 28, 2008 February 28, 2008 Phase 1 1 Assumptions and Ground Rules The goal is regulatory approval of

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

Nuevas tecnologías basadas en biomarcadores para oncología

Nuevas tecnologías basadas en biomarcadores para oncología Nuevas tecnologías basadas en biomarcadores para oncología Simposio ASEBIO 14 de marzo 2013, PCB Jose Jimeno, MD, PhD Co-Founder / Vice Chairman Pangaea Biotech SL Barcelona, Spain PANGAEA BIOTECH BUSINESS

More information

Local Clinical Trials

Local Clinical Trials Local Clinical Trials The Alzheimer s Association, Connecticut Chapter does not officially endorse any specific research study. The following information regarding clinical trials is provided as a service

More information

Version 1 2015. Module guide. Preliminary document. International Master Program Cardiovascular Science University of Göttingen

Version 1 2015. Module guide. Preliminary document. International Master Program Cardiovascular Science University of Göttingen Version 1 2015 Module guide International Master Program Cardiovascular Science University of Göttingen Part 1 Theoretical modules Synopsis The Master program Cardiovascular Science contains four theoretical

More information

DISCLOSURES RISK ASSESSMENT. Stroke and Heart Disease -Is there a Link Beyond Risk Factors? Daniel Lackland, MD

DISCLOSURES RISK ASSESSMENT. Stroke and Heart Disease -Is there a Link Beyond Risk Factors? Daniel Lackland, MD STROKE AND HEART DISEASE IS THERE A LINK BEYOND RISK FACTORS? D AN IE L T. L AC K L AN D DISCLOSURES Member of NHLBI Risk Assessment Workgroup RISK ASSESSMENT Count major risk factors For patients with

More information

Innovation Platform: Sudden Cardiac Death

Innovation Platform: Sudden Cardiac Death Innovation Platform: Sudden Cardiac Death Prof. dr. Bart Loeys CRC Antwerp General Assembly VzW Board of Directors Strategic Advisory Board Staff: 1 executive director 1 ICT manager 1 financial administration

More information

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine Graduate Certificate in Metabolic & Nutritional Medicine Graduate Certificate Metabolic & Nutritional Medicine Purpose

More information

Mental health issues in the elderly. January 28th 2008 Presented by Éric R. Thériault etheriau@lakeheadu.ca

Mental health issues in the elderly. January 28th 2008 Presented by Éric R. Thériault etheriau@lakeheadu.ca Mental health issues in the elderly January 28th 2008 Presented by Éric R. Thériault etheriau@lakeheadu.ca Cognitive Disorders Outline Dementia (294.xx) Dementia of the Alzheimer's Type (early and late

More information

Update in Hematology Oncology Targeted Therapies. Mark Holguin

Update in Hematology Oncology Targeted Therapies. Mark Holguin Update in Hematology Oncology Targeted Therapies Mark Holguin 25 years ago Why I chose oncology People How to help people with possibly the most difficult thing they may have to deal with Science Turning

More information

Your Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007

Your Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007 Your Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007 The cardiometabolic risk syndrome is increasingly recognized

More information

INSERM/ A. Bernheim. Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance

INSERM/ A. Bernheim. Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance A. Bernheim Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance OVER-MyR is funded by the European Commission within its FP7 specific

More information

Ariela Benigni. Biol.Sci.D., Ph.D. Curriculum Vitae

Ariela Benigni. Biol.Sci.D., Ph.D. Curriculum Vitae Ariela Benigni Biol.Sci.D., Ph.D. Curriculum Vitae Personal Data Name: Date and place of birth: Citizenship: E-mail: Ariela Benigni December 16, 1955 - Bergamo, Italy Italian ariela.benigni@marionegri.it

More information

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures

More information

Project ideas of University of Udine for Horizon 2020 Health 2014/2015 www.uniud.it

Project ideas of University of Udine for Horizon 2020 Health 2014/2015 www.uniud.it Project ideas of University of Udine for Horizon 2020 Health 2014/2015 www.uniud.it The University of Udine is an Italian Public University founded in 1978 by National Law No. August 8, 1977 546, art.

More information

Demystifying Stem Cells. Brent Bost M.D., CPA, MBA, FACOG

Demystifying Stem Cells. Brent Bost M.D., CPA, MBA, FACOG Demystifying Stem Cells Brent Bost M.D., CPA, MBA, FACOG Disclaimers Author currently serves on Board of Directors of CordTrack Most applications discussed today are not currently FDA approved and are,

More information

Future Oncology: Technology, Products, Market and Service Opportunities

Future Oncology: Technology, Products, Market and Service Opportunities Brochure More information from http://www.researchandmarkets.com/reports/296370/ Future Oncology: Technology, Products, Market and Service Opportunities Description: Future Oncology is an analytical newsletter

More information

Influenza (Flu) Influenza is a viral infection that may affect both the upper and lower respiratory tracts. There are three types of flu virus:

Influenza (Flu) Influenza is a viral infection that may affect both the upper and lower respiratory tracts. There are three types of flu virus: Respiratory Disorders Bio 375 Pathophysiology General Manifestations of Respiratory Disease Sneezing is a reflex response to irritation in the upper respiratory tract and is associated with inflammation

More information

placebo-controlledcontrolled double-blind, blind,

placebo-controlledcontrolled double-blind, blind, Clinical Potential of Minocycline for Depression with Psychotic Features Tsuyoshi Miyaoka Department of Psychiatry Shimane University School of Medicine Minocycline 1. Second-generation tetracycline which

More information

INTRODUCTION Thrombophilia deep vein thrombosis DVT pulmonary embolism PE inherited thrombophilia

INTRODUCTION Thrombophilia deep vein thrombosis DVT pulmonary embolism PE inherited thrombophilia INTRODUCTION Thrombophilia (Hypercoagulability) is a condition in which a person forms blood clots more than normal. Blood clots may occur in the arms or legs (e.g., deep vein thrombosis DVT), the lungs

More information

Fulfilling the Promise

Fulfilling the Promise Fulfilling the Promise Advancing the Fight Against Cancer: America s Medical Schools and Teaching Hospitals For more than a century, the nation s medical schools and teaching hospitals have worked to understand,

More information

ALLIANCE FOR LUPUS RESEARCH AND PFIZER S CENTERS FOR THERAPEUTIC INNOVATION CHALLENGE GRANT PROGRAM PROGRAM GUIDELINES

ALLIANCE FOR LUPUS RESEARCH AND PFIZER S CENTERS FOR THERAPEUTIC INNOVATION CHALLENGE GRANT PROGRAM PROGRAM GUIDELINES ALLIANCE FOR LUPUS RESEARCH AND PFIZER S CENTERS FOR THERAPEUTIC INNOVATION CHALLENGE GRANT PROGRAM PROGRAM GUIDELINES DESCRIPTION OF GRANT MECHANISM The Alliance for Lupus Research (ALR) is an independent,

More information

Ministero della Salute

Ministero della Salute Ministero della Salute Direzione Generale della Ricerca e dell' Innovazione in Sanità BANDO 2013 PROGRAMMI DI RETE FINANZIATI PROGRAMMA NETWORK CODICE: 02356160 SCORE MEDIO DEL NETWORK: 13,75 Pediatric

More information

By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH

By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH By Dr. Mindy Aisen CEO and Director United Cerebral Palsy Research and Educational Foundation www.ucpresearch.org CEREBRAL PALSY RESEARCH Main Sources of Federal Funding for Cerebral Palsy and Disability

More information

Stem Cell Quick Guide: Stem Cell Basics

Stem Cell Quick Guide: Stem Cell Basics Stem Cell Quick Guide: Stem Cell Basics What is a Stem Cell? Stem cells are the starting point from which the rest of the body grows. The adult human body is made up of hundreds of millions of different

More information

Stem cells for brain cures

Stem cells for brain cures 13-14/11/2006, Istituto Superiore di Sanità Rome, Italy Frontiers in Imaging Science: High Performance Nuclear Medicine Imagers for Vascular Disease Imaging (Brain and Heart) Stem cells for brain cures

More information

The type of cancer Your specific treatment Your pre training levels before diagnose (your current strength and fitness levels)

The type of cancer Your specific treatment Your pre training levels before diagnose (your current strength and fitness levels) Exercise and Breast Cancer: Things you can do! Cancer within the fire service is one of the most dangerous threats to our firefighter s health & wellness. According to the latest studies firefighters are

More information

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each

Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each Introduction 1.1 Introduction: About 10,500 new cases of acute myelogenous leukemia are diagnosed each year in the United States (Hope et al., 2003). Acute myelogenous leukemia has several names, including

More information

Vitamin D deficiency exacerbates ischemic cell loss and sensory motor dysfunction in an experimental stroke model

Vitamin D deficiency exacerbates ischemic cell loss and sensory motor dysfunction in an experimental stroke model Vitamin D deficiency exacerbates ischemic cell loss and sensory motor dysfunction in an experimental stroke model Robyn Balden & Farida Sohrabji Texas A&M Health Science Center- College of Medicine ISC

More information

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD Cord Blood Banking Scott N. Furlan, MD Ellen S.Plummer, MD Overview Background Biology of Stem Cell Transplant Opportunities i at Parkland Logistics of Banking Potential Barriers Indications for HCT Cancer

More information

micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved

micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved microrna 2 micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved Regulate gene expression by binding complementary regions at 3 regions of target mrnas Act as negative

More information

Pharmacology skills for drug discovery. Why is pharmacology important?

Pharmacology skills for drug discovery. Why is pharmacology important? skills for drug discovery Why is pharmacology important?, the science underlying the interaction between chemicals and living systems, emerged as a distinct discipline allied to medicine in the mid-19th

More information

1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT

1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT 1400 Telegraph Bloomfield Hills, MI 48302 248-334-6877-Phone number/248-334-6877-fax Number CANCER TREATMENT Learning that your pet has a diagnosis of cancer can be overwhelming. We realize that your pet

More information

Co-pay assistance organizations offering assistance

Co-pay assistance organizations offering assistance Acromegaly Acute Exacerbations of Multiple Sclerosis Acute Porphyrias Advanced Idiopathic Parkinson' s Disease Age-Related Macular Degeneration www.theassistancefund.org Alcohol Dependence Alpha-1 Antitrypsin

More information

The Brain and Spine CenTer

The Brain and Spine CenTer The Br ain and Spine Center Choosing the right treatment partner is important for patients facing tumors involving the brain, spine or skull base. The Brain and Spine Center at The University of Texas

More information

ACUTE MYELOID LEUKEMIA (AML),

ACUTE MYELOID LEUKEMIA (AML), 1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly

More information

The Prospect of Stem Cell Therapy in Multiple Sclerosis. Multiple sclerosis is a multifocal inflammatory disease of the central

The Prospect of Stem Cell Therapy in Multiple Sclerosis. Multiple sclerosis is a multifocal inflammatory disease of the central The Prospect of Stem Cell Therapy in Multiple Sclerosis Multiple sclerosis is a multifocal inflammatory disease of the central nervous system that generally affects young individuals, causing paralysis

More information

Your Certified Professional Cancer Coach. An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer

Your Certified Professional Cancer Coach. An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer Your Certified Professional Cancer Coach An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer The CPCC Patient Program Nutrition & Lifestyle Oncology A Cancer Diagnosis

More information

Enjoy a position of vantage, come what may.

Enjoy a position of vantage, come what may. Enjoy a position of vantage, come what may. prucrisis covervantage While you have achieved much in life and you and your family enjoy the benefits of success, there may be times when the unexpected happens.

More information

Immuno-Oncology Therapies to Treat Lung Cancer

Immuno-Oncology Therapies to Treat Lung Cancer Immuno-Oncology Therapies to Treat Lung Cancer What you need to know ONCHQ14NP07519 Introduction: Immuno-oncology represents an innovative approach to cancer research that seeks to harness the body s own

More information

6/3/2011. High Prevalence and Incidence. Low back pain is 5 th most common reason for all physician office visits in the U.S.

6/3/2011. High Prevalence and Incidence. Low back pain is 5 th most common reason for all physician office visits in the U.S. High Prevalence and Incidence Prevalence 85% of Americans will experience low back pain at some time in their life. Incidence 5% annual Timothy C. Shen, M.D. Physical Medicine and Rehabilitation Sub-specialty

More information

BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED

BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED ASX ANNOUNCEMENT 3 August 2011 ABN 53 075 582 740 BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED Data from renal cancer trial supports progression of the trial: o Combination

More information

GRANIX (tbo-filgrastim)

GRANIX (tbo-filgrastim) RATIONALE FOR INCLUSION IN PA PROGRAM Background Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils. A person with severe neutropenia has an absolute neutrophil

More information

Call 2014: High throughput screening of therapeutic molecules and rare diseases

Call 2014: High throughput screening of therapeutic molecules and rare diseases Call 2014: High throughput screening of therapeutic molecules and rare diseases The second call High throughput screening of therapeutic molecules and rare diseases launched by the French Foundation for

More information

Chapter 10. Summary & Future perspectives

Chapter 10. Summary & Future perspectives Summary & Future perspectives 123 Multiple sclerosis is a chronic disorder of the central nervous system, characterized by inflammation and axonal degeneration. All current therapies modulate the peripheral

More information

Normal and Abnormal Aging and the Brain. Joel Kramer, PsyD Saul Villeda, PhD Kristine Yaffe, MD

Normal and Abnormal Aging and the Brain. Joel Kramer, PsyD Saul Villeda, PhD Kristine Yaffe, MD Normal and Abnormal Aging and the Brain Joel Kramer, PsyD Saul Villeda, PhD Kristine Yaffe, MD The myth of cognitive decline The myth of cognitive decline Individual change varies Individual change varies

More information

Clinical and Therapeutic Cannabis Information. Written by Cannabis Training University (CTU) All rights reserved

Clinical and Therapeutic Cannabis Information. Written by Cannabis Training University (CTU) All rights reserved Clinical and Therapeutic Cannabis Information Written by Cannabis Training University (CTU) All rights reserved Contents Introduction... 3 Chronic Pain... 6 Neuropathic Pain... 8 Movement Disorders...

More information

A: Nursing Knowledge. Alberta Licensed Practical Nurses Competency Profile 1

A: Nursing Knowledge. Alberta Licensed Practical Nurses Competency Profile 1 A: Nursing Knowledge Alberta Licensed Practical Nurses Competency Profile 1 Competency: A-1 Anatomy and Physiology A-1-1 A-1-2 A-1-3 A-1-4 A-1-5 A-1-6 A-1-7 A-1-8 Identify the normal structures and functions

More information

The Lewin Group undertook the following steps to identify the guidelines relevant to the 11 targeted procedures:

The Lewin Group undertook the following steps to identify the guidelines relevant to the 11 targeted procedures: Guidelines The following is a list of proposed medical specialty guidelines that have been found for the 11 targeted procedures to be included in the Medicare Imaging Demonstration. The list includes only

More information

Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions

Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions IMPORTANCE OF HORMONE BALANCE Importance of Hormone Balance Help you live a long, healthy life Help you

More information

We understand you want support right from the beginning

We understand you want support right from the beginning PROTECT We understand you want support right from the beginning PRUearly stage crisis cover Should an illness strike, the earlier it is diagnosed, the easier it is to manage and the higher the chances

More information

A m e r i C A n A C A d e m y o f A N T I - A G i n G M e d i c i n e

A m e r i C A n A C A d e m y o f A N T I - A G i n G M e d i c i n e VOLUME II A m e r i C A n A C A d e m y o f A N T I - A G i n G M e d i c i n e Established in 1992 www.worldhealth.net Fellowship in Integrative Cancer Therapy The American Academy of Anti-aging Medicine

More information

Practice Guideline. Neuropsychological Evaluations

Practice Guideline. Neuropsychological Evaluations Practice Guideline Neuropsychological Evaluations Adapted from the practice guideline of the same name by the Arizona Department of Health Services Division of Behavioral Health Services Effective: 06/30/2006

More information

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer Breast Studies Adjuvant therapy after surgery Her 2 positive Breast Cancer B 52 Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients with Hormone

More information

Top Ten Things to Know About Stem Cell Treatments

Top Ten Things to Know About Stem Cell Treatments Top Ten Things to Know About Stem Cell Treatments Many clinics that are offering stem cell treatments make claims about what stem cells can and cannot do that are not supported by our understanding of

More information

ANIMALS FORM & FUNCTION BODY DEFENSES NONSPECIFIC DEFENSES PHYSICAL BARRIERS PHAGOCYTES. Animals Form & Function Activity #4 page 1

ANIMALS FORM & FUNCTION BODY DEFENSES NONSPECIFIC DEFENSES PHYSICAL BARRIERS PHAGOCYTES. Animals Form & Function Activity #4 page 1 AP BIOLOGY ANIMALS FORM & FUNCTION ACTIVITY #4 NAME DATE HOUR BODY DEFENSES NONSPECIFIC DEFENSES PHYSICAL BARRIERS PHAGOCYTES Animals Form & Function Activity #4 page 1 INFLAMMATORY RESPONSE ANTIMICROBIAL

More information

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in

More information

San Diego Stem Cell Treatment Center Frequently Asked Questions

San Diego Stem Cell Treatment Center Frequently Asked Questions San Diego Stem Cell Treatment Center Frequently Asked Questions What is a Stem Cell? A stem cell is basically any cell that can replicate and differentiate. This means the cell can not only multiply, but

More information

Report series: General cancer information

Report series: General cancer information Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for

More information

What is a Stem Cell Transplantation?

What is a Stem Cell Transplantation? What is a Stem Cell Transplantation? Guest Expert: Stuart, MD Associate Professor, Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Drs. Ed and Ken. I am

More information

Social Security Disability Insurance and young onset dementia: A guide for employers and employees

Social Security Disability Insurance and young onset dementia: A guide for employers and employees Social Security Disability Insurance and young onset dementia: A guide for employers and employees What is Social Security Disability Insurance? Social Security Disability Insurance (SSDI) is a payroll

More information

Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance

Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance INSTRUCTIONS - Please print all answers If required, retain a photocopy for your files. 1a) Plan contract number(s)

More information

Progressive Care Insurance for life A NEW TYPE OF INSURANCE

Progressive Care Insurance for life A NEW TYPE OF INSURANCE Progressive Care Insurance for life A NEW TYPE OF INSURANCE New Progressive Care from Sovereign Progressive Care is a type of insurance that is new to New Zealand. It s not a traditional all-or-nothing

More information

How can we generate economic value from personalized medicine and big data analysis?

How can we generate economic value from personalized medicine and big data analysis? Estonian Health Innovation Forum 2015 Focus on Personalised Medicine How can we generate economic value from personalized medicine and big data analysis? Jonathan Knowles October 26, 2015 Tallinn, Viru

More information

Summary of Discussion on Non-clinical Pharmacology Studies on Anticancer Drugs

Summary of Discussion on Non-clinical Pharmacology Studies on Anticancer Drugs Provisional Translation (as of January 27, 2014)* November 15, 2013 Pharmaceuticals and Bio-products Subcommittees, Science Board Summary of Discussion on Non-clinical Pharmacology Studies on Anticancer

More information

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease.

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Memory loss and changes in mood and behavior are some signs that you or a family member may have Alzheimer s disease. If you have

More information

A 43 year old male presents with abdominal complaints. An axial CT reveals.

A 43 year old male presents with abdominal complaints. An axial CT reveals. A 43 year old male presents with abdominal complaints. An axial CT reveals. Diagnosis: Gastrointestinal Stromal Tumor Location: stomach Size: 12 cm Mitotic count: 10 mitoses / 50 high power fields Risk

More information

What is PD? Dr Catherine Dotchin MD MRCP Consultant Geriatrician

What is PD? Dr Catherine Dotchin MD MRCP Consultant Geriatrician What is PD? Dr Catherine Dotchin MD MRCP Consultant Geriatrician Overview of presentation Case history Video example pre and post treatment Historical review PD in the UK Epidemiology and aetiology Making

More information

BOLETIN BIBLIOGRAFICO BIBLIOTECA MEDICA-HCG JUNIO 2014

BOLETIN BIBLIOGRAFICO BIBLIOTECA MEDICA-HCG JUNIO 2014 BOLETIN BIBLIOGRAFICO BIBLIOTECA MEDICA-HCG JUNIO 2014 Am J Clin Pathol 1. 2013 Statement on Human Papillomavirus DNA Test Utilization. AJCP 141 (4): 459-461, abr. 2014 2. Pathology Consultation on Electronic

More information

BNC105 PHASE II RENAL CANCER TRIAL RESULTS

BNC105 PHASE II RENAL CANCER TRIAL RESULTS ABN 53 075 582 740 ASX ANNOUNCEMENT 19 March 2014 BNC105 PHASE II RENAL CANCER TRIAL RESULTS Results show BNC105 utility in patients with advanced disease Identified biomarkers which correlate with patient

More information

LIVER CANCER AND TUMOURS

LIVER CANCER AND TUMOURS LIVER CANCER AND TUMOURS LIVER CANCER AND TUMOURS Healthy Liver Cirrhotic Liver Tumour What causes liver cancer? Many factors may play a role in the development of cancer. Because the liver filters blood

More information

chronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart

chronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Pre- B-cell B-cell Transformed B-cell Plasma cell Ig Surface Surface Secreted Major malignant counterpart

More information

Documentation Requirements ADHD

Documentation Requirements ADHD Documentation Requirements ADHD Attention Deficit Hyperactivity Disorder (ADHD) is considered a neurobiological disability that interferes with a person s ability to sustain attention, focus on a task

More information

Future Directions in Cancer Research What does is mean for medical physicists and AAPM?

Future Directions in Cancer Research What does is mean for medical physicists and AAPM? Future Directions in Cancer Research What does is mean for medical physicists and AAPM? John D. Hazle, Ph.D., FAAPM, FACR President-elect American Association of Physicists in Medicine Professor and Chairman

More information

Rheumatoid arthritis: an overview. Christine Pham MD

Rheumatoid arthritis: an overview. Christine Pham MD Rheumatoid arthritis: an overview Christine Pham MD RA prevalence Chronic inflammatory disease affecting approximately 0.5 1% of the general population Prevalence is higher in North America (approaching

More information

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div. Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under

More information