Ελένη Παπαδάκη. Καθηγήτρια Αιματολογίας Ιατρική Σχολή Παν/μίου Κρήτης. Τηλ

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1 Ελένη Παπαδάκη Καθηγήτρια Αιματολογίας Ιατρική Σχολή Παν/μίου Κρήτης Τηλ Ακαδημαϊκή και Ερευνητική Δραστηριότητα 2013-σήμερα 2007-σήμερα 2011-σήμερα 2011-σήμερα & σήμερα Αναπληρώτρια Πρύτανη Ακαδημαϊκών Υποθέσεων Παν/μίου Κρήτης. Καθηγήτρια Αιματολογίας Ιατρικής Σχολής Παν/μίου Κρήτης και Διευθύντρια της Αιματολογικής Κλινικής του ΠΑ.Γ.Ν.Η. Μέλος της Επιστημονικής Επιτροπής της Ευρωπαϊκής Ομάδος Μελέτης διαταραχών Ουδετεροφίλων και Μονοκυττάρων. Συντονίστρια της Επιτροπής Προπτυχιακών Σπουδών της Ιατρική Σχολή του Παν/μίου Κρήτης. Πρόεδρος της Ευρωπαϊκής Ομάδος Μελέτης διαταραχών Ουδετεροφίλων και Μονοκυττάρων. Πρόεδρος του Τμήματος Μυελοδυσπλαστικών Συνδρόμων και Μυελικής Ανεπάρκειας της Ελληνικής Αιματολογικής Εταιρείας. Επισκέπτρια Καθηγήτρια, Αιματολογική Κλινική, Παν/μιο Washington (Seattle, USA) (Μεταμοσχεύσεις μυελού). Υπεύθυνη του Εργαστηρίου Μελέτης Αιμοποίησης και του Εργαστηρίου Κυτταρομετρίας Ροής της Ιατρικής Σχολής του Παν/μίου Κρήτης Επίκουρη Καθηγήτρια Αιματολογίας, Ιατρική Σχολή Παν/μίου Κρήτης Visiting Scientist, Institute for Cancer Studies, Birmingham, UK (Μοριακή Βιολογία) Ερευνήτρια στο Εργαστήριο Αιματολογίας, Ιατρική Σχολή Saint George s, London Λέκτορας Αιματολογίας, Ιατρική Σχολή Παν/μίου Κρήτης Ειδικότητα Αιματολογίας, Πανεπιστημιακό Νοσοκομείο Ηρακλείου Διδακτορική Διατριβή στην Αιματολογία, Ιατρική Σχολή Παν/μίου Κρήτης Πτυχίο Ιατρικής Σχολής Παν/μίου Αθηνών, άριστα. Αντικείμενα Έρευνας Διερεύνηση των μηχανισμών ουδετεροπενίας και μυελικής ανεπάρκειας. Μελέτη των ιδιοτήτων των αρχέγονων μεσεγχυματικών κυττάρων.

2 2 Πρόσφατα Εθνικά και Διεθνή Ερευνητικά Προγράμματα Association for International Cancer Research, AICR. Study of the in vivo effect of an anti- TNFα monoclonal antibody (ca2) on bone marrow stem/progenitor cell reserve and function and on bone marrow stromal cell function in patients with myelodysplastic syndromes. ( ). 6FP, E.U. Genostem. Adult mesenchymal stem engineering for cartilage and bone repair. From the bench to the bedside ( ). Γενική Γραμματεία Έρευνας και Τεχνολογίας. ΠΕΝΕΔ, 03EΔ072. «Μελέτη των μεσεγχυματικών κυττάρων του μυελού ασθενών με Μυελοδυσπλαστικά Σύνδρομα» ( ). Γενική Γραμματεία Έρευνας και Τεχνολογίας. ΣΥΝΕΡΓΑΣΙΑ, 09SYN «Μελέτη του μηχανισμού της χρόνια ιδιοπαθούς ουδετεροπενίας» ( ). 7FP, TransPot, REGPOT Enhancing University of Crete Medical School Scientific Excellence and Translational Research Potential in Human Diseases ( ). Γενική Γραμματεία Έρευνας και Τεχνολογίας. ΣΥΝΕΡΓΑΣΙΑ, 11SYN «Δημιουργία δικτύου για την ενημέρωση του κοινού και για συλλογή, φύλαξη και χορήγηση των κυττάρων του ομφαλίου λώρου» ( ). Δημοσιεύσεις 1. Zeidler C, Grote UA, Nickel A, Brand B, Carlsson G, Cortesão E, Dufour C, Duhem C, Notheis G, Papadaki HA, Tamary H, Tjønnfjord GE, Tucci F, Van Droogenbroeck J, Vermylen C, Voglova J, Xicoy B, Welte K. Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry. Haematologica Aug;99(8): Palmblad J, Dufour C, Papadaki HA. How we diagnose neutropenia in the adult and elderly patient. Haematologica Jul;99(7): Marketou ME, Kalyva A, Parthenakis FI, Pontikoglou C, Maragkoudakis S, Kontaraki JE, Chlouverakis G, Zacharis EA, Patrianakos A, Papadaki HA, Vardas PE. Circulating endothelial progenitor cells in hypertensive patients with increased arterial stiffness. J Clin Hypertens (Greenwich) Apr;16(4): PMID: [PubMed - in process] 4. Pavlaki K, Pontikoglou CG, Demetriadou A, Batsali AK, Damianaki A, Simantirakis E, Kontakis M, Galanopoulos A, Kotsianidis I, Kastrinaki MC, Papadaki HA. Impaired Proliferative Potential of Bone Marrow Mesenchymal Stromal Cells in Patients with Myelodysplastic Syndromes Is Associated with Abnormal WNT Signaling Pathway. Stem Cells Dev Jul 15;23(14): Miltiades P, Lamprianidou E, Vassilakopoulos TP, Papageorgiou SG, Galanopoulos AG, Vakalopoulou S, Garypidou V, Papaioannou M, Hadjiharissi E, Pappa V, Papadaki HA, Spanoudakis E, Tsatalas K, Kotsianidis I. Expression of CD25 antigen on CD34+ cells is an independent predictor of outcome in late-stage MDS patients treated with azacitidine. Blood Cancer J Feb 28;4:e187. Related citations 6. Kalpadakis C, Pangalis GA, Angelopoulou MK, Sachanas S, Kontopidou F, Moschogiannis M, Ximeri M, Tsirkinidis P, Yiakoumis X, Papadaki HA, Vassilakopoulos TP. Validation of the simplified prognostic score for splenic marginal zone lymphoma of the Splenic Marginal Zone Lymphoma Working Group. Leuk Lymphoma Mar 25. [Epub ahead of print] No abstract available. 7. Kastrinaki MC, Pavlaki K, Batsali AK, Kouvidi E, Mavroudi I, Pontikoglou C, Papadaki HA. Mesenchymal stem cells in immune-mediated bone marrow failure syndromes. Clin Dev Immunol. 2013;2013: doi: /2013/ Epub 2013 Dec 10. Review. 8. Xochelli A, Kalpadakis C, Gardiner A, Baliakas P, Vassilakopoulos TP, Mould S, Davis Z, Stalika

3 3 E, Kanellis G, Angelopoulou MK, McIver-Brown N, Ibbotson R, Sachanas S, Korkolopoulou P, Athanasiadou A, Anagnostopoulos A, Papadaki HA, Papadaki T, Stamatopoulos K, Pangalis GA, Oscier D. Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity? Blood Feb 20;123(8): Manousou P, Kolios G, Drygiannakis I, Koulentaki M, Pyrovolaki K, Voumvouraki A, Notas G, Bourikas L, Papadaki HA, Kouroumalis E. CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin Exp Immunol Apr;172(1): Velegraki M, Papakonstanti E, Mavroudi I, Psyllaki M, Tsatsanis C, Oulas A, Iliopoulos I, Katonis P, Papadaki HA. Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production. Haematologica Aug;98(8): Batsali AK, Kastrinaki MC, Papadaki HA, Pontikoglou C. Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: biological properties and emerging clinical applications. Curr Stem Cell Res Ther Mar;8(2): Review. 12. Pontikoglou C, Kastrinaki MC, Klaus M, Kalpadakis C, Katonis P, Alpantaki K, Pangalis GA, Papadaki HA. Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. Stem Cells Dev May 1;22(9): Mavroudi I, Papadaki HA. Genetic associations in acquired immune-mediated bone marrow failure syndromes: insights in aplastic anemia and chronic idiopathic neutropenia. Clin Dev Immunol. 2012;2012: doi: /2012/ Epub 2012 Aug 26. Review. 14. Mastrodemou S, Vazgiourakis V, Velegraki M, Pavlaki K, Goulielmos GN, Papadaki HA. Clonal patterns of X-chromosome inactivation in peripheral blood cells of female patients with chronic idiopathic neutropenia. Haematologica Dec;97(12): Antoniou KM, Margaritopoulos GA, Proklou A, Karagiannis K, Lasithiotaki I, Soufla G, Kastrinaki MC, Spandidos DA, Papadaki HA, Siafakas NM. Investigation of Telomerase/Telomeres system in Bone Marrow Mesenchymal Stem Cells derived from IPF and RA-UIP. J Inflamm (Lond) Jul 2;9(1): Pavlaki KI, Kastrinaki MC, Klontzas M, Velegraki M, Mavroudi I, Papadaki HA. Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia. Haematologica May;97(5): Velegraki M, Koutala H, Tsatsanis C, Papadaki HA. Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. J Clin Immunol Apr;32(2): Mavroudi I, Papadaki HA. The role of CD40/CD40 ligand interactions in bone marrow granulopoiesis. ScientificWorldJournal. 2011;11: Gemetzi C, Mavroudi I, Koutala H, Velegraki M, Choulaki C, Damianaki A, Pontikoglou C, Papadaki HA. Lymphopenia in patients with chronic idiopathic neutropenia is associated with decreased number of T-lymphocytes containing T-cell receptor excision circles. Eur J Haematol Mar;88(3): Pontikoglou C, Kalpadakis C, Papadaki HA. Pathophysiologic mechanisms and management of neutropenia associated with large granular lymphocytic leukemia. Expert Rev Hematol Jun;4(3): Mavroudi I, Papadaki V, Pyrovolaki K, Katonis P, Eliopoulos AG, Papadaki HA. The CD40/CD40 ligand interactions exert pleiotropic effects on bone marrow granulopoiesis. J Leukoc Biol May;89(5): Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA. Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev Sep;7(3):

4 4 23. Klaus M, Psaraki A, Mastrodemou S, Pyrovolaki K, Mavroudi I, Kalpadakis C, Papadaki HA. Evaluation of TET2 deletions in myeloid disorders: a fluorescence in situ hybridization analysis of 109 cases. Leuk Res Mar;35(3): Manousou P, Kolios G, Valatas V, Drygiannakis I, Bourikas L, Pyrovolaki K, Koutroubakis I, Papadaki HA, Kouroumalis E. Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. Clin Exp Immunol Nov;162(2): Stavroulaki E, Kastrinaki MC, Pontikoglou C, Eliopoulos D, Damianaki A, Mavroudi I, Pyrovolaki K, Katonis P, Papadaki HA. Mesenchymal stem cells contribute to the abnormal bone marrow microenvironment in patients with chronic idiopathic neutropenia by overproduction of transforming growth factor-β1. Stem Cells Dev Aug;20(8): Spanoudakis M, Koutala H, Ximeri M, Pyrovolaki K, Stamatopoulos K, Papadaki HA. T-cell receptor Vβ repertoire analysis in patients with chronic idiopathic neutropenia demonstrates the presence of aberrant T-cell expansions. Clin Immunol Dec;137(3): Mavroudi I, Pyrovolaki K, Pavlaki K, Kozana A, Psyllaki M, Kalpadakis C, Pontikoglou C, Papadaki HA.Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on megakaryopoiesis of patients with lower risk myelodysplastic syndrome. Leuk Res Mar;35(3): Kastrinaki MC, Pontikoglou C, Klaus M, Stavroulaki E, Pavlaki K, Papadaki HA. Biologic characteristics of bone marrow mesenchymal stem cells in myelodysplastic syndromes. Curr Stem Cell Res Ther Jun;6(2): Review. 29. Pontikoglou C, Papadaki HA. Idiosyncratic drug-induced agranulocytosis: the paradigm of deferiprone. Hemoglobin Jun;34(3): Antoniou KM, Papadaki HA, Soufla G, Kastrinaki MC, Damianaki A, Koutala H, Spandidos DA, Siafakas NM. Investigation of bone marrow mesenchymal stem cells (BM MSCs) involvement in Idiopathic Pulmonary Fibrosis (IPF). Respir Med Oct;104(10): Klaus M, Stavroulaki E, Kastrinaki MC, Fragioudaki P, Giannikou K, Psyllaki M, Pontikoglou C, Tsoukatou D, Mamalaki C, Papadaki HA. Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. Stem Cells Dev Jul;19(7): Ximeri M, Galanopoulos A, Klaus M, Parcharidou A, Giannikou K, Psyllaki M, Symeonidis A, Pappa V, Kartasis Z, Liapi D, Hatzimichael E, Kokoris S, Korkolopoulou P, Sambani C, Pontikoglou C, Papadaki HA; Hellenic MDS Study Group. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion. Haematologica Mar;95(3): Nakou M, Katsikas G, Sidiropoulos P, Bertsias G, Papadimitraki E, Raptopoulou A, Koutala H, Papadaki HA, Kritikos H, Boumpas DT. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response. Arthritis Res Ther. 2009;11(4):R Eliopoulos DG, Mavroudi I, Pontikoglou C, Ximeri M, Stavroulaki E, Pyrovolaki K, Velegraki M, Spanoudakis M, Goulielmos G, Papadaki HA. The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia. Eur J Haematol Dec 1;83(6): Kalpadakis C, Pangalis GA, Dimitriadou E, Angelopoulou MK, Siakantaris MP, Kyrtsonis MC, Ximeris M, Tzenou T, Sahanas S, Yiakoumis X, Papadaki EA, Panayiotidis P, Vassilakopoulos T. Mutation analysis of IgVH genes in splenic marginal zone lymphomas: correlation with clinical characteristics and outcome. Anticancer Res May;29(5): Polioudaki H, Kastrinaki MC, Papadaki HA, Theodoropoulos PA. Microtubule-interacting drugs induce moderate and reversible damage to human bone marrow mesenchymal stem cells. Cell Prolif Aug;42(4):

5 5 37. Antoniou KM, Papadaki HA, Soufla G, Siafakas NM. Short telomeres and treatment of pulmonary fibrosis: implications for early intervention. Am J Respir Crit Care Med May 15;179(10): Pyrovolaki K, Mavroudi I, Sidiropoulos P, Eliopoulos AG, Boumpas DT, Papadaki HA. Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: contribution to Fas-mediated apoptosis. Arthritis Rheum Feb;60(2): Kastrinaki MC, Papadaki HA. Mesenchymal stromal cells in rheumatoid arthritis: biological properties and clinical applications. Curr Stem Cell Res Ther Jan;4(1):61-9. Review. 40. Roche S, Delorme B, Oostendorp RA, Barbet R, Caton D, Noel D, Boumediene K, Papadaki HA, Cousin B, Crozet C, Milhavet O, Casteilla L, Hatzfeld J, Jorgensen C, Charbord P, Lehmann S. Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signature. Proteomics Jan;9(2): Papadaki HA, Pontikoglou C. Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia.expert Rev Hematol Dec;1(2): Ziakas PD, Papadaki HA, Psyllaki M, Voulgarelis M. Anti-thrombopoietin antibodies suppress megakaryocytic colony formation in vitro in patients with systemic lupus erythaematosus. Ann Rheum Dis Nov;67(11): Kastrinaki MC, Andreakou I, Charbord P, Papadaki HA. Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. Tissue Eng Part C Methods Dec;14(4): Manousou P, Kolios G, Drygiannakis I, Pyrovolaki K, Bourikas L, Papadaki HA, Kouroumalis E. Expression of a splice variant of CXCR3 in Crohn's disease patients; indication for a lymphocyte-- epithelial cell interaction. J Gastroenterol Hepatol Dec;23(12): Stavropoulou C, Sambani C, Rigana H, Georgakakos VN, Voutsinas G, Manola KN, Pantelias GE, Makropoulos V; Hellenic MDS Study Group. Low frequency of the glutathione-s-transferase T1-null genotype in patients with primary myelodysplastic syndrome and 5q deletion. Leukemia Aug;22(8): doi: /leu Stamatopoulos K, Papadaki T, Pontikoglou C, Athanasiadou I, Stavroyianni N, Bux J, Batsis I, Pyrovolaki K, Paterakis G, Anagnostou D, Anagnostopoulos A, Papadaki HA. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia Jul;22(7): Roubelakis MG, Pappa KI, Bitsika V, Zagoura D, Vlahou A, Papadaki HA, Antsaklis A, Anagnou NP. Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev Dec;16(6): Palmblad J, Papadaki HA. Chronic idiopathic neutropenias and severe congenital neutropenia.curr Opin Hematol Jan;15(1):8-14. Review. 49. Pyrovolaki K, Mavroudi I, Papadantonakis N, Velegraki M, Ximeri M, Kalpadakis C, Gvazava G, Klaus M, Eliopoulos GD, Papadaki HA. Transforming growth factor-beta1 affects interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia. Eur J Haematol Dec;79(6): Galanopoulos AG, Symeonidis A, Kourakli A, Papadaki EA, Tsaftaridis P, Terpos E, Aktipi A, Roussou P, Protopappa M, Pappaioannou M, Zikos P, Speletas M, Parcharidou A, Laoutaris N, Anagnostopoulos NI, Meletis J, Pangalis GA, Zoumbos N, Viniou N; Hellenic MDS Study Group. Prognostic significance of deletion of the long arm of chromosome 20 in patients with myelodysplastic syndrome (MDS): a study of the Greek MDS Study Group. Eur J Haematol Jan;78(1): No abstract available. 51. Kastrinaki MC, Sidiropoulos P, Roche S, Ringe J, Lehmann S, Kritikos H, Vlahava VM, Delorme B, Eliopoulos GD, Jorgensen C, Charbord P, Häupl T, Boumpas DT, Papadaki HA. Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis. Ann Rheum Dis Jun;67(6):741-9.

6 6 52. Repapinou Z, Karababa P, Boussiou M, Kafarakis V, Papadaki HA, Mavroudis D, Eliopoulos GD, Loutradi-Anagnostou A. An improved method for the diagnostic approach of alpha+-thalassaemia. Int J Lab Hematol Feb;29(1): Froudarakis ME, Papadaki HA, Klimathianaki M, Damianaki A, Pougounias M, Kotsianidis I, Astoul P. Thoracoscopic talc poudrage decreases T-lymphocytes in the peripheral blood. Respir Med Jun;101(6): Epub 2006 Dec Koumaki V, Damianaki A, Ximeri M, Pontikoglou C, Axioti F, Spanoudakis M, Eliopoulos GD, Papadaki HA. Pro-inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin-10. Br J Haematol Nov;135(4): Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp Hematol Oct;34(10): Psyllaki M, Damianaki A, Gemetzi C, Pyrovolaki K, Eliopoulos GD, Papadaki HA. Impaired megakaryopoiesis in patients with chronic idiopathic neutropenia is associated with increased transforming growth factor beta1 production in the bone marrow. Br J Haematol Sep;134(6): Boula A, Voulgarelis M, Giannouli S, Katrinakis G, Psyllaki M, Pontikoglou C, Markidou F, Eliopoulos GD, Papadaki HA. Effect of ca2 anti-tumor necrosis factor-alpha antibody therapy on hematopoiesis of patients with myelodysplastic syndromes. Clin Cancer Res May 15;12(10): Tsoumakidou M, Tzanakis N, Papadaki HA, Koutala H, Siafakas NM. Isolation of myeloid and plasmacytoid dendritic cells from human bronchoalveolar lavage fluid. Immunol Cell Biol Jun;84(3): Papadaki HA, Damianaki A, Pontikoglou C, Pyrovolaki K, Eliopoulos DG, Stavroulaki E, Eliopoulos GD. Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia. Br J Haematol Mar;132(5): Lygnos MC, Pappa KI, Papadaki HA, Relakis C, Koumantakis E, Anagnou NP, Eliopoulos GD. Changes in maternal plasma levels of VEGF, bfgf, TGF-beta1, ET-1 and skl during uncomplicated pregnancy, hypertensive pregnancy and gestational diabetes. In Vivo Jan-Feb;20(1): Papadaki HA, Pontikoglou C, Eliopoulos DG, Pyrovolaki K, Spyridaki R, Eliopoulos GD. Helicobacter pylori infection is probably the cause of chronic idiopathic neutropenia (CIN)-associated splenomegaly. Am J Hematol Feb;81(2): Mantadakis E, Pontikoglou C, Papadaki HA, Aggelidakis G, Samonis G. Fatal Fournier's gangrene in a young adult with acute lymphoblastic leukemia.pediatr Blood Cancer Nov;49(6): Papadaki HA, Pontikoglou C, Stavroulaki E, Eliopoulos DG, Mavroudi I, Spanoudakis M, Eliopoulos GD. Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. Ann Hematol Mar;85(3): Papadaki HA, Tsagournisakis M, Mastorodemos V, Pontikoglou C, Damianaki A, Pyrovolaki K, Stamatopoulos K, Fassas A, Plaitakis A, Eliopoulos GD. Normal bone marrow hematopoietic stem cell reserves and normal stromal cell function support the use of autologous stem cell transplantation in patients with multiple sclerosis. Bone Marrow Transplant Dec;36(12): Mavrogianni D, Tsaftaridis P, Terpos E, Symeonidis A, Galanopoulus A, Papadaki EA, Zoumbos N, Meletis J, Pangalis GA, Viniou N. Macrophage Inflammatory Protein-1 alpha (MIP-1alpha) is overexpressed in a cohort of patients with myelodysplastic syndromes. Eur J Haematol Jul;75(1): Pontikoglou C, Fragos C, Kolyvaki E, Samonis G, Eliopoulos GD, Papadaki HA. Multiple myeloma involving the central nervous system: a report of two cases with unusual manifestations. Leuk Lymphoma May;46(5):

7 7 67. Papadaki HA, Stamatopoulos K, Damianaki A, Gemetzi C, Anagnostopoulos A, Papadaki T, Eliopoulos AG, Eliopoulos GD. Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. Br J Haematol Mar;128(6): Papadaki HA, Pontikoglou C, Stavroulaki E, Minadakis G, Eliopoulos DA, Pyrovolaki K, Skordilis P, Eliopoulos GD. High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia. Ann Hematol May;84(5): Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Snowden J, Markham AF, Ma D, van Laar JM, Papadaki HA, Emery P, Isaacs JD. Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia. Arthritis Res Ther. 2005;7(1):R Epub 2004 Nov Christoforidou AV, Papadaki HA, Margioris AN, Eliopoulos GD, Tsatsanis C. Expression of the Tpl2/Cot oncogene in human T-cell neoplasias. Mol Cancer Dec 3;3(1): Papadaki HA, Tsatsanis C, Christoforidou A, Malliaraki N, Psyllaki M, Pontikoglou C, Miliaki M, Margioris AN, Eliopoulos GD. Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. J Bone Miner Metab. 2004;22(6): Megalakaki A, Mitsouli C, Pontikoglou C, Iakovidou J, Koumaki V, Eliopoulos GD, Papadaki HA. Chronic idiopathic neutropenia preceding polymyalgia rheumatica and acute myeloid leukemia. 73. Ann Hematol Dec;83(12): Epub 2004 Aug 25. No abstract available. 74. Papadaki HA, Kosteas T, Gemetzi C, Damianaki A, Anagnou NP, Eliopoulos GD. Acute myeloid/nk precursor cell leukemia with trisomy 4 and a novel point mutation in the extracellular domain of the G-CSF receptor in a patient with chronic idiopathic neutropenia. Ann Hematol Jun;83(6): Papadaki HA, Kosteas T, Gemetzi C, Christoforidou A, Anagnou NP, Eliopoulos GD. Low serum gamma-glutamyltranspeptidase (GGT) in patients with chronic idiopathic neutropenia is not implicated in the pathophysiology of the disease. Haematologica Nov;88(11):ELT Papadaki HA, Eliopoulos GD. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle Sep-Oct;2(5): Papadaki HA. Autoreactive T-lymphocytes are implicated in the pathogenesis of bone marrow failure in patients with systemic lupus erythematosus. Leuk Lymphoma Aug;44(8): Koumaki V, Papadaki HA, Stefanaki K, Damianaki A, Gemetzi C, Katonis P, Vrentzos G, Eliopoulos GD. Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia. Ann Hematol Oct;82(10): Papadaki HA, Skordilis P, Minadakis G, Roussomoustakaki M, Katrinakis G, Psyllaki M, Tzardi M, Kouroumalis E, Eliopoulos GD. Complete regression of primary gastric plasmacytoma following Helicobacter pylori eradication. Ann Hematol Sep;82(9): Person RE, Li FQ, Duan Z, Benson KF, Wechsler J, Papadaki HA, Eliopoulos G, Kaufman C, Bertolone SJ, Nakamoto B, Papayannopoulou T, Grimes HL, Horwitz M. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet Jul;34(3): Papadaki HA, Xylouri I, Katrinakis G, Foudoulakis A, Kritikos HD, Stathopoulos EN, Boumpas DT, Eliopoulos GD. Non-Hodgkin's lymphoma in patients with systemic lupus erythematosus.leuk Lymphoma Feb;44(2): Papadaki HA, Horwitz M, Coulocheri SA, Person RA, Benson KF, Eliopoulos GD. Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia. Blood Apr 1;101(7): No abstract available.

8 8 83. Papadaki HA, Eliopoulos AG, Kosteas T, Gemetzi C, Damianaki A, Koutala H, Bux J, Eliopoulos GD. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood Apr 1;101(7): Papadaki HA, Michelakaki H, Bux J, Eliopoulos GD. Severe autoimmune neutropenia associated with bone marrow sea-blue histiocytosis. Br J Haematol Sep;118(4): Papadaki HA, Marsh JC, Eliopoulos GD. Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk Lymphoma Apr;43(4): Review. 86. Papadaki HA, Kritikos HD, Valatas V, Boumpas DT, Eliopoulos GD. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood Jul 15;100(2): Palmblad J, Papadaki HA, Eliopoulos G. Acute and chronic neutropenias. What is new?j Intern Med Dec;250(6): Papadaki HA, Kritikos HD, Gemetzi C, Koutala H, Marsh JC, Boumpas DT, Eliopoulos GD. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood Mar 1;99(5): Erratum in: Blood May 15;109(10): Papadaki HA, Gibson FM, Psyllaki M, Gordon-Smith EC, Marsh JC, Eliopoulos GD. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with severe congenital neutropenia. Eur J Haematol Oct;67(4): Papadaki HA, Kosteas T, Gemetzi C, Alexandrakis M, Psyllaki M, Eliopoulos GD. Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. Ann Hematol Jan;81(1):50-4. Epub 2001 Dec Papadaki HA, Boumpas DT, Gibson FM, Jayne DR, Axford JS, Gordon-Smith EC, Marsh JC, Eliopoulos GD. Increased apoptosis of bone marrow CD34(+) cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus. Br J Haematol Oct;115(1): Papadaki HA, Palmblad J, Eliopoulos GD. Non-immune chronic idiopathic neutropenia of adult: an overview. Eur J Haematol Jul;67(1): Review. 93. Papadaki HA, Charoulakis NZ, Eliopoulos DG, Psyllaki M, Eliopoulos GD. Patients with nonimmune chronic idiopathic neutropenia syndrome have increased splenic volume on ultrasonography. Clin Lab Haematol Apr;23(2): Papadaki HA, Eliopoulos DG, Valatas V, Eliopoulos GD. Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. Ann Hematol Apr;80(4): Papadaki HA, Eliopoulos DG, Ponticoglou C, Eliopoulos GD. Increased frequency of monoclonal gammopathy of undetermined significance in patients with nonimmune chronic idiopathic neutropenia syndrome. Int J Hematol Apr;73(3): Papadaki HA, Psyllaki M, Eliopoulos DG, Tsiroyianni A, Eliopoulos GD. Increased frequency and specific reactivity of serum antinuclear antibodies in patients with nonimmune chronic idiopathic neutropenia of adults. Acta Haematol. 2001;105(1): Papadaki HA, Eliopoulos GD, Coulocheri SA, Spyropoulou M, Stavropoulos-Giokas C. Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. Blood Jan 15;97(2): Papadaki HA, Chatzivassili A, Stefanaki K, Koumaki V, Kanavaros P, Eliopoulos GD. Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Ann Hematol Oct;79(10):

9 9 99. Papadaki HA, Coulocheri S, Eliopoulos GD. Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines. Am J Hematol Dec;65(4): Papadaki HA, Palmblad J, Kapsimali V, Anagnou NP, Eliopoulos GD. Increased serum IgA and decreased IgG3 strongly correlate with increased serum TGF-beta1 levels in patients with nonimmune chronic idiopathic neutropenia of adults. Eur J Haematol Oct;65(4): Papadaki HA, Gibson FM, Rizzo S, Gordon-Smith EC, Marsh JC. Assessment of bone marrow stem cell reserve and function and stromal cell function in patients with autoimmune cytopenias.blood Nov 1;96(9): Papadaki HA, Vardakis C, Vaiopoulos G, Nanas J, Eliopoulos GD. Extensive calcification of the pericardium in a patient with primary amyloidosis. Ann Hematol Jul;79(7): Papadaki HA, Kouroumalis EA, Stefanaki K, Roussomoustakaki M, Daskalogiannaki ME, Reppa D, Eliopoulos GD. Retractile mesenteritis presenting as fever of unknown origin and autoimmune haemolytic anaemia.digestion. 2000;61(2): Rizzo S, Scopes J, Elebute MO, Papadaki HA, Gordon-Smith EC, Gibson FM. Stem cell defect in aplastic anemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient bone marrow. Hematol J. 2002;3(5): Papadaki HA, Stefanaki K, Kanavaros P, Katonis P, Papastathi H, Valatas W, Stylianoy K, Eliopoulos GD. Epstein-Barr virus-associated high-grade anaplastic plasmacytoma in a renal transplant patient. Leuk Lymphoma Jan;36(3-4): Papadaki HA, Giouremou K, Eliopoulos GD. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-beta1 by bone marrow stromal cells. Eur J Haematol Sep;63(3): Papadaki HA, Xylouri I, Coulocheri S, Kalmanti M, Kafatos A, Eliopoulos GD. Prevalence of chronic idiopathic neutropenia of adults among an apparently healthy population living on the island of Crete.Ann Hematol Jul;78(7): Papadaki HA, Margioris AN, Miliaki M, Steriopoulos C, Valatas W, Eliopoulos GD. Chronic idiopathic neutropenia of adults is associated with decreased bone mineral density and alterations in bone turnover biochemical markers. Eur J Haematol May;62(5): Papadaki HA, Eliopoulos GD. Selective loss of peripheral blood CD45RO+ T lymphocytes correlates with increased levels of serum cytokines and endothelial cell-derived soluble cell adhesion molecules in patients with chronic idiopathic neutropenia of adults. Ann Hematol Oct;77(4): Papadaki HA, Eliopoulos GD. Enhanced neutrophil extravasation may be a contributing factor in the determination of neutropenia in patients with chronic idiopathic neutropenia of adults.eur J Haematol Oct;61(4): Papadaki HA, Xylouri I, Valatas W, Petinarakis J, Kontopoulou I, Eliopoulos GD. Severe acquired hemophilia A successfully treated with activated recombinant human factor VII. Ann Hematol Sep;77(3): Vaiopoulos G, Boki K, Kapsimali V, Coulocheri S, Papadaki HA, Eliopoulos GD. Hemoglobin levels correlate with serum soluble CD23 and TNF-Rs concentrations in patients with rheumatoid arthritis. Haematologia (Budap). 1998;29(2): Papadaki HA, Coulocheri S, Xylouri I, Chatzivassili A, Konsolas J, Katrinakis G, Karkavitsas N, Eliopoulos GD. Defective natural killer cell activity of peripheral blood lymphocytes correlates with the degree of neutropenia in patients with chronic idiopathic neutropenia of adults. Ann Hematol Mar-Apr;76(3-4): Kyriakou D, Papadaki H, Eliopoulos AG, Foudoulakis A, Alexandrakis M, Eliopoulos GD. Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein. Int J Hematol Oct;66(3):

10 Kyriakou D, Papadaki HA, Sakellariou D, Eliopoulos AG, Kapsimali V, Eliopoulos GD. Flowcytometric analysis of peripheral blood lymphocytes in patients with chronic idiopathic neutropenia of adults. Ann Hematol Sep;75(3): Papadaki H, Konsolas J, Chatzivassili A, Katrinakis G, Foudoulakis A, Markidou F, Alexandrakis M, Kyriakou D, Eliopoulos GD. Inhibition of mitogen-induced cellular cytotoxicity by serum from patients with multiple myeloma. Haematologia (Budap). 1997;28(3): Papadaki H, Kyriakou D, Foudoulakis A, Markidou F, Alexandrakis M, Eliopoulos GD. Serum levels of soluble IL-6 receptor in multiple myeloma as indicator of disease activity. Acta Haematol. 1997;97(4): Katrinakis G, Kyriakou D, Papadaki H, Kalokyri I, Markidou F, Eliopoulos GD. Defective natural killer cell activity in B-cell chronic lymphocytic leukaemia is associated with impaired release of natural killer cytotoxic factor(s) but not of tumour necrosis factor-alpha. Acta Haematol. 1996;96(1): Vaiopoulos G, Kyriakou D, Papadaki H, Fessas P, Eliopoulos GD. Multiple myeloma associated with autoimmune hemolytic anemia. Haematologica May-Jun;79(3): Vaiopoulos G, Kyriakou D, Papadaki H, Kaklamanis P, Eliopoulos GD. Defective mitogeninduced cellular cytotoxicity in untreated patients with active rheumatoid arthritis. Rheumatol Int. 1994;14(3): Eliopoulos GD, Vaiopoulos G, Kyriakou D, Eliopoulos AG, Papadaki H, Katrinakis G, Alexandrakis M. Impaired release of natural killer cytotoxic factor(s) by peripheral blood lymphocytes in patients with chronic LGL-proliferative disease. Haematologica Jul-Aug;78(4):