Saving Your Baby s Cord Blood

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1 Saving Your Baby s Cord Blood An Important Pregnancy Decision CORD BLOOD

2 HEALTHY FUTURES ARE Born at CBR For every parent who wishes they could do more to protect their family s health, there s Cord Blood Registry. Protect Your Family At Birth Every family deserves a healthy future. Cord blood banking is the first step. The newborn stem cells found in your baby s umbilical cord are especially valuable because they offer lifesaving treatments today and hope for healthier tomorrows. Newborn Stem Cells Are: Unique: Newborn stem cells have advantages over the adult stem cells found in bone marrow. They re younger, more versatile, easier to collect, and have not been exposed to damaging environmental factors. 1 Powerful: Cord blood stem cells have been used to treat more than 80 serious diseases, including leukemias. Cord blood also is being used in clinical trials as a potential treatment for conditions like cerebral palsy, brain injury, and autism. Smart: They have the ability to migrate to injured areas in the body and initiate the healing process. 2 Only One Chance to Bank Ensure that your family has access to this potentially lifesaving medicine by saving your baby s cord blood. You only have one chance to collect and store at birth. Saving your newborn s stem cells with Cord Blood Registry is surprisingly affordable! CORD BLOOD

3 The CBR Difference Healthy futures are born at CBR. Our superior technology, service, and commitment to finding new stem cell treatments were developed with one thing in mind protecting your family s health. Only CBR Offers You Most Experience As the largest, most experienced bank, we re able to help families get the most from their investment. CBR has saved newborn stem cells for more than 400,000 children and released more samples for use than any other family bank. Chloe was diagnosed with cerebral palsy when she was 9 months old. When she was 2, she received her own cord blood in an experimental treatment. Today, after physical therapy and her cord blood infusion, she s running, jumping, and hitting milestones we never thought possible. Jenny Levine Chloe s mom Most Cells Having more cells has been linked to better treatment outcomes. 3,4 Our exclusive CellAdvantage collection and processing system allows us to recover up to 20% more cells than other common processing methods. 5 7 Most Security Peace of mind comes from knowing we ll be here when you need us. CBR s state-of-the-art laboratory and history of sound investments are just two of the reasons we re unsurpassed when it comes to security. CBR is Most Preferred #1 Choice of Ob/Gyns CBR is the #1 choice of Ob/Gyns. In fact, Ob/Gyns prefer CBR, 2-to-1, for their own families over other companies. #1 In Clinical Trials CBR is the only family bank partnering with researchers to establish FDA-regulated clinical trials. This means our clients have exclusive access today to several current studies that may change medicine in the future. MEET Tom The CBR Difference begins with our people Tom Moore, Founder We store every single sample as if it were my grandchild s. Each one is processed with exactly the same care and precision. Learn more at cordblood.com/familyfirst

4 Cord Blood Stem Cell Treatments and Clinical Trial Uses Treatments Available Today Cord blood has been used successfully for more than 20 years. Today, more than 25,000 cord blood stem cell transplants have been conducted 8 to treat more than 80 serious diseases and disorders. Below are some examples. Clinical Trial Uses CBR partners with leading researchers and medical institutions to help uncover more uses for newborn stem cells. To ensure consistent quality, several FDA-regulated clinical trials only accept CBR clients. Cancers Acute Leukemia Chronic Leukemia High-Risk Solid Tumors Hodgkin s & Non-Hodgkin s Lymphoma Myelodysplastic Syndrome Blood Disorders Severe Aplastic Anemia Beta Thalassemia Diamond-Blackfan Anemia Fanconi Anemia Sickle Cell Disease Immune Disorders Chronic Granulomatous Disease Hystiocytic Disorders Leukocyte Adhesion Deficiency Severe Combined Immunodeficiency Diseases Wiskott-Aldrich Syndrome Metabolic Disorders Krabbe Disease Hurler Syndrome Metachromatic Leukodystrophy Sanfilippo Syndrome Call CBR for a complete list. Autism A CBR-exclusive clinical trial is assessing the use of cord blood to treat select patients with autism. Traumatic Brain Injury A CBR-exclusive clinical trial is determining if cord blood can help the brain repair itself. Cerebral Palsy Multiple clinical trials are evaluating the use of cord blood infusions to treat the effects of cerebral palsy. Juvenile Diabetes* A clinical trial is investigating the ability of cord blood to maintain insulin production in children with diabetes. Pediatric Stroke A CBR-exclusive clinical trial is researching cord blood as a potential treatment for effects of pediatric stroke. *No longer accepting participants If you have specific treatment questions, please consult your physician for the latest information. Source: Medical literature and clinicaltrials.gov. Second Source for stem Cells Cord Tissue Stem Cells May Help Heal the Body in a Different Way Your baby s umbilical cord tissue is a second source for valuable stem cells that are different from the primary stem cells found in cord blood. Researchers are looking at how these cells may help heal the body in new ways. In laboratory studies, cord tissue stem cells have demonstrated the power to heal: Spinal cord injuries 9 Cartilage damage 10 Brain trauma (from stroke) 11 More than 30 clinical trials worldwide are evaluating cord tissue s ability to help the body heal. Although this research is at an early stage and medical treatments are not currently available, researchers believe these cells have potential. Learn more about cord tissue s healing power at cordblood.com

5 Why Expecting Parents Bank Nothing is more important than protecting your family. For 20 years, hundreds of thousands of expecting parents have chosen to save their newborns stem cells in CBR s state-of-the-art lab. There are many compelling reasons why: When Keegan s leukemia emerged for a second time, cord blood stem cells from his younger brother Keldan helped him defeat cancer. My little brother saved my life. If it weren t for him, I wouldn t be here. Keegan Doheney Preparing for a Healthy Future Today s data on the likelihood of needing stem cells about 1 in every 217 people 12 doesn t account for treatments currently being evaluated in clinical trials. Banking helps ensure that more treatment options are available to your family if the unexpected happens. Family Matching Saving for every child is important. A child is always a perfect match to his or her own stem cells, but in some cases, a matched sibling donor would be preferred. Access to Latest Uses Banking gives families more choices and access to today s uses. For example, a child needs his or her own stem cells to participate in the latest treatments being researched in the U.S. for conditions such as autism, brain injury, and cerebral palsy. Concern About Finding a Donor If needed, finding a matching stem cell donor may be difficult. Banking for every child at birth saves genetically matching stem cells. Sparrow s Story When Sparrow was 2 years old, she fell in a pool and nearly drowned, resulting in a severe brain injury. Because her parents had saved her cord blood stem cells, Sparrow was able to receive an infusion of her own stem cells in an experimental treatment. Watch Sparrow s story at cordblood.com/sparrow

6 You Can Afford the Best When it comes to investing in your family s future health, experience and quality matter. Fortunately, banking with the best may be more affordable than you think. Call CORD BLOOD to learn about our payment options: Payment Plans Short-term, interest-free options Extended plans with low monthly payments Gift Registry Create your personalized CBR Gift Registry to invite friends and family to give a little toward something that means a lot. The sooner you open your account, the more you may save! No fees are due until your baby arrives. Payment plan options and full terms and conditions are available at cordblood.com. Some plans are subject to credit approval. Many of our friends and family preferred to contribute toward Zoe s cord blood banking gift registry. It cut our cost of banking in half! Casey T. CBR Client References: 1. Hao Q, et al. A functional comparison of CD34+ CD38- cells in cord blood and bone marrow. Blood. 1995;86: Meier C, et al. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatric Research. 2006;59: Brunstein CG, et al. Expanding the role of umbilical cord blood transplantation. Br J Haematol. 2007;137(1): Scaradavou A, et al. Cord Blood (CB) Unit Mononuclear Cell (MNC) Dose: Effect on transplantation outcome and relevance to processing method and CBU selection. Blood. 2008;112: Rosenthal J, et al. Stem cell recovery following implementation of an automated cord blood processing system in a high volume laboratory. Biol Blood Marrow Transplant. 2008;14(2): Kurtzberg J, et al. Results of the Cord Blood Transplantation (COBLT) study unrelated donor banking program. Transfusion. 2005;45: Papassavas AC, et al. A strategy of splitting individual high volume cord blood units into two half subunits prior to processing increases the recovery of cells and facilitates ex vivo expansion of the infused haematopoietic progenitor cells in adults. Int Jnl Lab Hem. 2008;30(2); Butler MG, et al. Umbilical cord blood banking: an update. J Assist Reprod Genet. 2011;28(8): Yang CC, et al. Transplantation of human umbilical mesenchymal stem cells from Wharton s jelly after complete transection of the rat spinal cord. PLoS ONE. 2008;3(10):e Bailey MM, et al. A comparison of human umbilical cord matrix stem cells and temporomandibular joint condylar chondrocytes for tissue engineering temporomandibular joint condylar cartilage. Tissue Eng. Aug 2007;13(8): Liao W, et al. Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke. Transplantation. Feb 15, 2009;87(3): Nietfeld JJ, et al. Lifetime probabilities of hematopoietic stem cell transplantation in the U.S. Biol Blood Marrow Transplant. Mar 2008;14(3):

7 Call CBR today for your free information kit: CORD BLOOD ( ) Monday Friday, 6:00 am 9:00 pm PT Saturday Sunday, 6:00 am 4:00 pm PT or learn more at cordblood.com Join the conversation Ultimate use of newborn stem cells will be determined by the treating physician, who will consider if they are applicable for the condition and should come from the patient or a suitable donor (like an HLA-matched sibling). There is no guarantee that treatments being studied in the laboratory or clinical trials will be available in the future. Source for Ob/Gyn claim: Blind survey, GfK Market Measures, 07/12, funded by CBR. Specific to cord tissue: Cbr Systems, Inc. s activities for New York State residents are limited to collection of umbilical cord tissue and long-term storage of umbilical cord-derived stem cells. Cbr Systems, Inc. s possession of a New York State license for such collection and long-term storage does not indicate approval or endorsement of possible future uses or future suitability of these cells Cbr Systems, Inc. All rights reserved MA

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