IMMUNOASSAY PREMIUM PLUS LEVEL 3 (IA PREMIUM PLUS 3)

0843 IMMUNOASSAY PREMIUM PLUS LEVEL 3 (IA PREMIUM PLUS 3) Cat. No.: IA3111 / IA3112 Lot No.: 1130EC Size.: 12 x 5ml / 12 x 5ml Expiry.: 2014-10 INTENDED USE This product is intended for in vitro diagnostic use in the quality control of the accuracy of Immunoassays on clinical chemistry systems. This material can be used to monitor the control of accuracy or the control of reproducibility of Immunoassays. SAFETY PRECAUTIONS AND WARNINGS For in vitro diagnostic use only. Do not pipette by mouth. Exercise the normal precautions required for handling laboratory reagents. Human source material from which this product has been derived has been tested at donor level for the Human Immunodeficiency Virus (HIV 1, HIV 2) antibody, Hepatitis B Surface Antigen (HbsAg), and Hepatitis C Virus (HCV) antibody and found to be NON- REACTIVE. FDA approved methods have been used to conduct these tests. However, since no method can offer complete assurance as to the absence of infectious agents, this material and all patient samples should be handled as though capable of transmitting infectious diseases and disposed of accordingly. Health and Safety Data Sheets are available on request. STORAGE AND STABILITY OPENED: Store refrigerated (+2 C to +8 C). Reconstituted serum is stable for 7 days at +2 C to +8 C if kept capped in original container and free from contamination or 4 weeks frozen once at -20 C. 25-OH Vitamin D is stable for 5 days at +2 C to +8 C. C-Peptide is stable for 1 day at +2 C to +8 C. Parathyroid hormone (PTH) and Thyroglobulin should be tested within 4 hours of reconstitution, when stored at +2 C to +8 C or within 2 weeks when stored at -20 C. No frozen stability claim is made for ACTH, Aldosterone and C-Peptide. Only the required amount of product should be removed. After use, any residual product should NOT BE RETURNED to the original vial. UNOPENED: Store refrigerated (+2 C to +8 C). Stable to expiration date printed on individual vials. Bacterial contamination of the reconstituted serum will cause reductions in the stability of many components. If bacterial contamination is suspected, the vial should be discarded and a fresh vial reconstituted. PREPARATION Immunoassay Premium Plus is supplied lyophilised. 1. Carefully reconstitute each vial of lyophilised serum with exactly 5ml of distilled water at +15 C to +25 C. Close bottle and allow to stand for 30 minutes before use. Ensure contents are completely dissolved by swirling gently. Avoid formation of foam. Do not shake. 2. Refer to the control section of the individual analyser application. 3. Refrigerate any unused material. Prior to reuse, mix contents thoroughly. MATERIALS PROVIDED Immunoassay Premium Plus - Level 3: 12 x 5ml Tri-Level: 12 x 5ml MATERIAL REQUIRED BUT NOT PROVIDED Volumetric Pipette VALUE ASSIGNMENT Each batch of Immunoassay Premium Plus is submitted to a number of reference laboratories and values are assigned from a consensus of results obtained by these laboratories using a unique statistical analysis. With each batch, a control range is provided for individual parameters and each parameter method. The control range is equivalent to the assigned mean ±2 S.D. This results in extremely accurate values, which may be confidently used by laboratories to ensure the accuracy of their methods. Aldosterone, 1,25 OH Vitamin D, ACTH and Estriol are present in the control, but values are not provided for all levels. If a method is unavailable, contact Randox Laboratories - Technical Support, Northern Ireland, tel: +44 (0) 28 9442 2413 or email Technical.Support@randox.com Revised 22 Jun 12 pl PAGE 1 OF 19

17-OH-Progesterone nmol/l 65.9 51.3 80.5 Siemens Coat-a-Count ng/ml 21.8 17.0 26.6 25-OH Vitamin D nmol/l 75.1 54.0 96.2 Diasorin Liaison nmol/l 57.8 43.4 72.2 Roche Elecsys nmol/l 55.5 41.6 69.4 Roche Cobas E411 nmol/l 57.8 43.4 72.3 Roche Modular E170 nmol/l 64.0 48.0 80.0 Abbott Architect ACTH pmol/l 27.3 20.5 34.1 Siemens Immulite 1000 pg/ml 124 93.2 155 Aldosterone pmol/l 626 438 814 Siemens Coat-a-Count pg/ml 226 158 294 Alphafoetoprotein KIU/l = lu/ml 162 125 199 Abbott AXSYM ng/ml 196 151 241 KIU/l = lu/ml 156 125 187 BioMerieux Vidas ng/ml 189 151 227 KIU/l = lu/ml 165 132 198 Siemens Immulite 1000 ng/ml 200 160 240 KIU/l = lu/ml 182 146 218 Roche Elecsys ng/ml 220 177 263 KIU/l = lu/ml 165 132 198 Vitros ECi ng/ml 200 160 240 KIU/l = lu/ml 178 141 215 Siemens Advia Centaur ng/ml 215 170 260 KIU/l = lu/ml 160 128 192 Siemens Immulite 2000/2500 ng/ml 194 155 233 KIU/l = lu/ml 166 133 199 Abbott Architect ng/ml 201 161 241 KIU/l = lu/ml 175 140 210 Roche Modular E170 ng/ml 212 169 255 KIU/l = lu/ml 173 135 211 Beckman DxI800 ng/ml 209 163 255 KIU/l = lu/ml 180 144 216 Roche Cobas 6000 ng/ml 218 174 262 KIU/l = lu/ml 176 141 211 Roche Cobas E411 ng/ml 213 171 255 KIU/l = lu/ml 157 140 174 Pishtaz Teb- ELISA ng/ml 190 170 210 Amikacin µmol/l 24.1 19.3 28.9 Gravimetric µg/ml 14.1 11.3 16.9 Beta-2-microglobulin µg/ml = mg/l 7.42 5.91 8.93 BioMerieux Vidas µg/ml = mg/l 6.42 4.82 8.02 Roche Tinaquant µg/ml = mg/l 7.18 5.74 8.62 Behring Nephelometer RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 2 OF 19

Beta-2-microglobulin µg/ml = mg/l 4.89 3.91 5.87 Abbott AXSYM µg/ml = mg/l 5.70 4.56 6.84 Siemens Immulite 2000/2500 µg/ml = mg/l 6.79 5.43 8.15 Abbott Architect µg/ml = mg/l 6.37 5.10 7.64 Roche Cobas 6000 C-Peptide nmol/l 2.150 1.610 2.690 Siemens Immulite 2000/2500 ng/ml 6.49 4.86 8.12 nmol/l 2.340 1.760 2.930 Roche Modular E170 ng/ml 7.06 5.31 8.81 nmol/l 1.840 1.380 2.300 Siemens Advia Centaur ng/ml 5.55 4.17 6.93 CA 15-3 U/ml 75.2 60.2 90.2 Roche Elecsys U/ml 73.0 58.4 87.6 BioMerieux Vidas U/ml 71.8 49.5 94.1 Siemens Advia Centaur U/ml 65.8 52.6 79.0 Abbott Architect U/ml 93.7 75.0 112 Siemens Immulite 2000/2500 U/ml 58.2 44.2 72.2 Abbott AXSYM U/ml 72.9 58.3 87.5 Vitros ECi U/ml 71.5 57.2 85.8 Diasorin Liaison U/ml 77.0 61.6 92.4 Roche Modular E170 U/ml 43.2 34.6 51.8 Beckman Access U/ml 42.0 33.6 50.4 Beckman DxI800 U/ml 76.0 60.8 91.2 Roche Cobas 6000 U/ml 74.3 59.4 89.2 Roche Cobas E411 CA 19-9 U/ml 151 110 192 Abbott AXSYM U/ml 163 130 196 BioMerieux Vidas U/ml 115 92.0 138 Roche Elecsys U/ml 183 126 240 Siemens Advia Centaur U/ml 126 98.7 153 Siemens Immulite 2000/2500 U/ml 454 363 545 Abbott Architect U/ml 259 207 311 Vitros ECi U/ml 109 87.2 131 Roche Modular E170 U/ml 131 105 157 Beckman DxI800 U/ml 447 358 536 Abbott Architect XR kit U/ml 107 85.6 128 Roche Cobas 6000 U/ml 111 88.8 133 Roche Cobas E411 CA125 U/ml 167 125 209 Abbott AXSYM U/ml 173 138 208 Siemens Immulite 1000 U/ml 155 124 186 BioMerieux Vidas U/ml 150 120 180 Roche Elecsys U/ml 143 114 172 Siemens Immulite 2000/2500 U/ml 145 116 174 Vitros ECi U/ml 152 122 182 Roche Modular E170 U/ml 177 142 212 Abbott Architect U/ml 154 106 202 Siemens ADVIA Centaur CA125 II kit U/ml 143 114 172 Beckman Access U/ml 138 110 166 Beckman DxI800 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 3 OF 19

CA125 U/ml 149 119 179 Roche Cobas E411 U/ml 151 121 181 Roche Cobas 6000 Carbamazepine µmol/l 65.6 52.5 78.7 Vitros µg/ml 15.5 12.4 18.6 µmol/l 67.7 54.2 81.2 Abbott AXSYM µg/ml 16.0 12.8 19.2 µmol/l 73.9 45.8 102 Siemens Advia Centaur µg/ml 17.5 10.9 24.1 µmol/l 68.3 54.6 82.0 Siemens Immulite 1000 µg/ml 16.1 12.9 19.3 µmol/l 77.1 61.7 92.5 Roche Integra µg/ml 18.2 14.6 21.8 µmol/l 72.6 58.1 87.1 Roche Modular E170 µg/ml 17.2 13.7 20.7 µmol/l 75.0 60.0 90.0 Abbott Architect µg/ml 17.7 14.2 21.2 µmol/l 67.7 54.2 81.2 Roche Cobas E411 µg/ml 16.0 12.8 19.2 µmol/l 69.0 55.2 82.8 Roche Cobas 6000 µg/ml 16.3 13.0 19.6 µmol/l 68.8 55.0 82.6 Roche Modular µg/ml 16.3 13.0 19.6 µmol/l 72.3 57.8 86.8 Gravimetric µg/ml 17.1 13.7 20.5 Carcinoembryonic ng/ml = µg/l 63.3 47.5 79.1 Abbott AXSYM Antigen (CEA) ng/ml = µg/l 56.0 44.8 67.2 BioMerieux Vidas ng/ml = µg/l 76.8 61.4 92.2 Siemens Immulite 1000 ng/ml = µg/l 53.5 42.8 64.2 Roche Elecsys ng/ml = µg/l 61.1 48.9 73.3 Vitros ECi ng/ml = µg/l 63.0 50.4 75.6 Beckman Access ng/ml = µg/l 56.3 38.8 73.8 Siemens Advia Centaur ng/ml = µg/l 79.4 63.5 95.3 Siemens Immulite 2000/2500 ng/ml = µg/l 69.1 55.3 82.9 Abbott Architect ng/ml = µg/l 52.1 41.7 62.5 Roche Modular E170 ng/ml = µg/l 60.7 48.6 72.8 Beckman DxI800 ng/ml = µg/l 53.0 42.4 63.6 Roche Cobas 6000 ng/ml = µg/l 54.5 43.6 65.4 Roche Cobas E411 ng/ml = µg/l 70.0 57.0 83.0 Pishtaz Teb- ELISA Cortisol nmol/l 1038 755 1321 Abbott AXSYM µg/dl 37.4 27.2 47.6 nmol/l 1032 792 1272 BioMerieux Vidas µg/dl 37.2 28.5 45.9 nmol/l 1138 854 1423 Siemens Immulite 1000 µg/dl 41.0 30.7 51.3 nmol/l 1047 785 1309 Siemens Coat-a-Count µg/dl 37.7 28.3 47.1 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 4 OF 19

Cortisol nmol/l 1059 794 1324 Roche Elecsys µg/dl 38.1 28.6 47.6 nmol/l 1034 776 1293 Beckman Access µg/dl 37.2 27.9 46.5 nmol/l 1060 731 1389 Siemens Advia Centaur µg/dl 38.2 26.4 50.0 nmol/l 1127 845 1409 Siemens Immulite 2000/2500 µg/dl 40.6 30.4 50.8 nmol/l 923 692 1154 Vitros ECi µg/dl 33.2 24.9 41.5 nmol/l 860 645 1075 Abbott Architect µg/dl 31.0 23.2 38.8 nmol/l 1035 776 1294 Diasorin Liaison µg/dl 37.3 27.9 46.7 nmol/l 1017 763 1271 Roche Modular E170 µg/dl 36.6 27.5 45.7 nmol/l 991 743 1239 Beckman DxI800 µg/dl 35.7 26.7 44.7 nmol/l 1025 769 1281 Roche Cobas 6000 µg/dl 36.9 27.7 46.1 nmol/l 1059 794 1324 Roche Cobas E411 µg/dl 38.1 28.6 47.6 DHEA-S µmol/l 25.1 20.1 30.1 Siemens Immulite 1000 µmol/l 24.6 19.7 29.5 Siemens Immulite 2000/2500 µmol/l 28.8 23.0 34.6 Roche Modular E170 µmol/l 33.5 26.8 40.2 Abbott Architect µmol/l 24.7 19.8 29.6 Beckman DxI800 µmol/l 28.9 23.1 34.7 Roche Cobas 6000 Digoxin nmol/l 4.97 3.98 5.96 Beckman Access ng/ml 3.88 3.11 4.65 nmol/l 4.49 3.59 5.39 Abbott AXSYM ng/ml 3.51 2.80 4.22 nmol/l 4.68 3.74 5.62 Vitros ng/ml 3.66 2.92 4.40 nmol/l 5.35 4.28 6.42 Siemens Immulite 1000 ng/ml 4.18 3.34 5.02 nmol/l 5.69 4.55 6.83 Roche Elecsys ng/ml 4.44 3.55 5.33 nmol/l 5.21 4.06 6.36 Siemens Advia Centaur ng/ml 4.07 3.17 4.97 nmol/l 4.59 3.67 5.51 Vitros ECi ng/ml 3.58 2.87 4.29 nmol/l 5.27 4.01 6.53 Roche Modular E170 ng/ml 4.12 3.13 5.11 nmol/l 4.36 3.49 5.23 Abbott Architect ng/ml 3.41 2.73 4.09 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 5 OF 19

Digoxin nmol/l 4.70 3.76 5.64 Beckman DxI800 ng/ml 3.67 2.94 4.40 nmol/l 4.74 3.79 5.69 Roche Cobas 6000 ng/ml 3.70 2.96 4.44 nmol/l 5.12 4.10 6.14 Gravimetric ng/ml 4.00 3.20 4.80 Ethosuximide µmol/l 493 394 592 Gravimetric µg/ml 69.9 55.9 83.9 Ferritin ng/ml = µg/l 321 225 417 Abbott AXSYM ng/ml = µg/l 287 230 344 BioMerieux Vidas ng/ml = µg/l 265 212 318 Siemens Immulite 1000 ng/ml = µg/l 291 233 349 Roche Elecsys ng/ml = µg/l 235 188 282 Beckman Access ng/ml = µg/l 207 166 248 Vitros ECi ng/ml = µg/l 303 236 370 Siemens Advia Centaur ng/ml = µg/l 286 229 343 Siemens Immulite 2000/2500 ng/ml = µg/l 355 284 426 Abbott Architect ng/ml = µg/l 295 236 354 Roche Modular E170 ng/ml = µg/l 277 222 332 Siemens Dimension ng/ml = µg/l 227 182 272 Beckman DxI800 ng/ml = µg/l 308 246 370 Roche Cobas E411 ng/ml = µg/l 297 238 356 Roche Cobas 6000 ng/ml = µg/l 250 205 295 Pishtaz Teb- ELISA Folate nmol/l 36.5 27.7 45.3 Abbott AXSYM ng/ml 16.1 12.2 20.0 nmol/l 29.5 22.4 36.6 Beckman Access ng/ml 13.0 9.88 16.1 nmol/l 30.4 23.1 37.7 Siemens Immulite 1000 ng/ml 13.4 10.2 16.6 nmol/l 40.9 31.1 50.7 Roche Elecsys ng/ml 18.0 13.7 22.3 nmol/l 27.2 20.7 33.7 Siemens Immulite 2000 ng/ml 12.0 9.13 14.9 nmol/l 19.1 14.5 23.7 Vitros ECi ng/ml 8.42 6.39 10.5 nmol/l 39.0 29.6 48.4 Abbott Architect ng/ml 17.2 13.1 21.3 nmol/l 42.7 32.5 52.9 Roche Modular E170 ng/ml 18.8 14.3 23.3 nmol/l 63.9 38.3 89.5 Siemens ADVIA Centaur (enhanced kit) ng/ml 28.2 16.9 39.5 nmol/l 30.7 23.3 38.1 Beckman DxI800 ng/ml 13.5 10.3 16.7 nmol/l 41.9 31.8 52.0 Roche Cobas E411 ng/ml 18.5 14.0 23.0 nmol/l 41.4 31.5 51.3 Roche Cobas 6000 ng/ml 18.3 13.9 22.7 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 6 OF 19

Folate nmol/l 38.5 29.3 47.7 Abbott Architect restandardised ng/ml 17.0 12.9 21.1 Free T3 pmol/l 26.6 19.8 33.4 Abbott AXSYM ng/dl 1.73 1.29 2.17 pg/ml 17.3 12.9 21.7 pmol/l 23.2 17.4 29.0 BioMerieux Vidas ng/dl 1.51 1.13 1.89 pg/ml 15.1 11.3 18.9 pmol/l 28.4 21.3 35.5 Roche Elecsys ng/dl 1.85 1.38 2.32 pg/ml 18.5 13.9 23.1 pmol/l 20.7 15.5 25.9 Beckman Access ng/dl 1.35 1.01 1.69 pg/ml 13.5 10.1 16.9 pmol/l 16.0 12.0 20.0 Siemens Immulite 1000 ng/dl 1.04 0.780 1.30 pg/ml 10.4 7.81 13.0 pmol/l 35.1 26.3 43.9 Vitros ECi ng/dl 2.28 1.71 2.85 pg/ml 22.9 17.1 28.7 pmol/l 20.9 12.5 29.3 Siemens Advia Centaur ng/dl 1.36 0.816 1.90 pg/ml 13.6 8.16 19.0 pmol/l 17.5 13.1 21.9 Siemens Immulite 2000/2500 ng/dl 1.14 0.852 1.43 pg/ml 11.4 8.53 14.3 pmol/l 24.0 18.0 30.0 Abbott Architect ng/dl 1.56 1.17 1.95 pg/ml 15.6 11.7 19.5 pmol/l 27.9 20.9 34.9 Roche Modular E170 ng/dl 1.81 1.36 2.26 pg/ml 18.2 13.6 22.8 pmol/l 19.7 14.8 24.6 Beckman DxI800 ng/dl 1.28 0.962 1.60 pg/ml 12.8 9.63 16.0 pmol/l 27.9 20.9 34.9 Roche Cobas E411 ng/dl 1.81 1.36 2.26 pg/ml 18.2 13.6 22.8 pmol/l 28.2 21.2 35.3 Roche Cobas 6000 ng/dl 1.83 1.38 2.28 pg/ml 18.4 13.8 23.0 pmol/l 11.5 9.20 13.8 Pishtaz Teb- ELISA ng/dl 0.750 0.600 0.900 pg/ml 7.50 6.00 9.00 Free T4 pmol/l 37.2 31.6 42.8 Abbott AXSYM ng/dl 2.90 2.46 3.34 pg/ml 29.0 24.6 33.4 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 7 OF 19

Free T4 pmol/l 45.8 38.9 52.7 BioMerieux Vidas ng/dl 3.57 3.03 4.11 pg/ml 35.7 30.3 41.1 pmol/l 72.9 62.0 83.8 Siemens Immulite 1000 ng/dl 5.69 4.84 6.54 pg/ml 56.9 48.4 65.4 pmol/l 65.9 56.0 75.8 Roche Elecsys ng/dl 5.14 4.37 5.91 pg/ml 51.4 43.7 59.1 pmol/l 51.9 44.1 59.7 Beckman Access ng/dl 4.05 3.44 4.66 pg/ml 40.5 34.4 46.6 pmol/l 78.2 66.5 89.9 Tosoh AIA360 ng/dl 6.10 5.19 7.01 pg/ml 61.0 51.9 70.1 pmol/l 90.0 76.5 104 Vitros ECi ng/dl 7.02 5.97 8.07 pg/ml 70.2 59.7 80.7 pmol/l 50.5 42.9 58.1 Siemens Advia Centaur ng/dl 3.94 3.35 4.53 pg/ml 39.4 33.5 45.3 pmol/l 71.8 61.0 82.6 Siemens Immulite 2000/2500 ng/dl 5.60 4.76 6.44 pg/ml 56.0 47.6 64.4 pmol/l 64.0 54.4 73.6 Abbott Architect ng/dl 4.99 4.24 5.74 pg/ml 49.9 42.4 57.4 pmol/l 98.3 83.6 113 Diasorin Liaison ng/dl 7.67 6.52 8.82 pg/ml 76.7 65.2 88.2 pmol/l 66.3 56.4 76.2 Roche Modular E170 ng/dl 5.17 4.40 5.94 pg/ml 51.7 44.0 59.4 pmol/l 55.4 47.1 63.7 Beckman DxI800 ng/dl 4.32 3.67 4.97 pg/ml 43.2 36.7 49.7 pmol/l 67.4 57.3 77.5 Roche Cobas 6000 ng/dl 5.26 4.47 6.05 pg/ml 52.6 44.7 60.5 pmol/l 65.8 55.9 75.7 Roche Cobas E411 ng/dl 5.13 4.36 5.90 pg/ml 51.3 43.6 59.0 pmol/l 46.6 39.6 53.6 Monobind Inc. ELISA ng/dl 3.63 3.09 4.17 pg/ml 36.3 30.9 41.7 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 8 OF 19

Free T4 pmol/l 71.9 57.8 86.0 Pishtaz Teb- ELISA ng/dl 5.60 4.50 6.70 pg/ml 56.0 45.0 67.0 Free Testosterone pmol/l 55.7 40.7 70.7 Siemens Coat-a-Count pg/ml 16.0 11.7 20.3 FSH mu/ml 68.4 54.7 82.1 Tosoh AIA360 mu/ml 68.5 54.8 82.2 Siemens Immulite 1000 mu/ml 72.0 57.6 86.4 BioMerieux Vidas mu/ml 60.0 48.0 72.0 Abbott AXSYM mu/ml 75.2 60.2 90.2 Beckman Access mu/ml 65.9 52.7 79.1 Roche/BM Elecsys mu/ml 49.7 39.8 59.6 Vitros ECi mu/ml 81.2 63.3 99.1 Siemens Advia Centaur mu/ml 65.1 52.1 78.1 Siemens Immulite 2000/2500 mu/ml 57.5 46.0 69.0 Abbott Architect mu/ml 76.5 61.2 91.8 Diasorin Liaison mu/ml 61.0 48.8 73.2 Roche Modular E170 mu/ml 73.7 59.0 88.4 Beckman DxI800 mu/ml 65.4 52.3 78.5 Roche Cobas E411 mu/ml 61.9 49.5 74.3 Roche Cobas 6000 mu/ml 43.1 34.5 51.7 Human Elisys UNO mu/ml 93.0 83.0 103 Pishtaz Teb- ELISA Gentamicin µmol/l 11.7 9.36 14.0 Gravimetric µg/ml 5.59 4.47 6.69 Growth Hormone (GH) µu/ml 64.0 51.2 76.8 Siemens Immulite 1000 ng/ml 21.3 17.0 25.6 µu/ml 56.2 45.0 67.4 Siemens Immulite 2000/2500 ng/ml 18.7 15.0 22.4 µu/ml 47.7 38.2 57.2 Beckman DxI800 ng/ml 15.9 12.7 19.1 Immunoglobulin E KIU/l = IU/ml 508 406 610 Siemens Immulite 1000 KIU/l = IU/ml 527 409 645 BioMerieux Vidas KIU/l = IU/ml 479 383 575 Beckman Access KIU/l = IU/ml 488 390 586 Pharmacia Unicap KIU/l = IU/ml 542 434 650 Roche Elecsys KIU/l = IU/ml 474 284 664 Siemens Advia Centaur KIU/l = IU/ml 496 389 603 Siemens Immulite 2000/2500 KIU/l = IU/ml 532 426 638 Roche Modular E170 KIU/l = IU/ml 515 412 618 Beckman DxI800 KIU/l = IU/ml 398 318 478 Abbott Architect KIU/l = IU/ml 532 426 638 Roche Cobas E411 KIU/l = IU/ml 537 430 644 Roche Cobas 6000 KIU/l = IU/ml 412 362 462 Pishtaz Teb- ELISA Insulin mu/l 18.4 13.8 23.0 Siemens Advia Centaur mu/l 22.4 16.8 28.0 Abbott AXSYM RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 9 OF 19

Insulin mu/l 2.00 1.50 2.50 Siemens Immulite 1000 mu/l 18.8 14.1 23.5 Roche Modular E170 mu/l 19.3 14.5 24.1 Roche Elecsys mu/l 16.5 12.4 20.6 Abbott Architect mu/l 18.9 14.2 23.6 Roche Cobas E411 mu/l 18.6 14.0 23.3 Roche Cobas 6000 mu/l 16.3 12.2 20.4 Beckman DxI800 Luteinising Hormone mu/ml 63.4 50.7 76.1 Abbott AXSYM (LH) mu/ml 47.0 37.6 56.4 Beckman Access mu/ml 55.7 44.6 66.8 BioMerieux Vidas mu/ml 71.9 57.5 86.3 Siemens Immulite 1000 mu/ml 57.9 46.3 69.5 Tosoh AIA360 mu/ml 57.7 46.2 69.2 Roche Elecsys mu/ml 55.2 44.2 66.2 Vitros ECi mu/ml 59.7 46.0 73.4 Siemens Advia Centaur mu/ml 69.6 55.7 83.5 Siemens Immulite 2000 mu/ml 53.7 43.0 64.4 Abbott Architect mu/ml 75.0 60.0 90.0 Diasorin Liaison mu/ml 56.3 45.0 67.6 Roche Modular E170 mu/ml 45.8 36.6 55.0 Beckman DxI800 mu/ml 57.0 45.6 68.4 Roche Cobas E411 mu/ml 56.1 44.9 67.3 Roche Cobas 6000 mu/ml 55.4 44.3 66.5 Human Elisys UNO mu/ml 38.0 31.0 45.0 Pishtaz Teb- ELISA Oestradiol pmol/l 672 534 810 Abbott AXSYM pg/ml 183 145 221 pmol/l 2384 1907 2861 BioMerieux Vidas pg/ml 648 519 777 pmol/l 2118 1694 2542 Siemens Immulite 1000 pg/ml 576 461 691 pmol/l 1537 1230 1844 Roche Elecsys pg/ml 418 335 501 pmol/l 1861 1489 2233 Vitros ECi pg/ml 506 405 607 pmol/l 1947 1558 2336 Siemens Immulite 2000/2500 pg/ml 530 424 636 pmol/l 1074 859 1289 Abbott Architect pg/ml 292 234 350 pmol/l 1514 1211 1817 Roche Modular E170 pg/ml 412 329 495 pmol/l 2497 1998 2996 Beckman DxI800 pg/ml 679 543 815 pmol/l 1498 1198 1798 Roche Cobas 6000 pg/ml 407 326 488 pmol/l 1503 1202 1804 Roche Cobas E411 pg/ml 409 327 491 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 10 OF 19

Oestradiol pmol/l 890 552 1228 Siemens Advia Centaur E26 III pg/ml 242 150 334 Paracetamol mmol/l 0.440 0.352 0.528 Roche Modular E170 mg/l 66.6 53.3 79.9 mmol/l 0.500 0.400 0.600 Roche Integra mg/l 75.7 60.5 90.9 mmol/l 0.510 0.408 0.612 Siemens Advia Centaur mg/l 77.2 61.7 92.7 mmol/l 0.529 0.420 0.630 Gravimetric mg/l 80.0 63.5 95.3 Parathyroid Hormone pmol/l 54.0 43.2 64.8 Siemens Advia Centaur (PTH) pg/ml 513 410 616 pmol/l 51.4 39.0 63.8 Siemens Immulite 1000 pg/ml 488 370 606 pmol/l 56.5 45.2 67.8 Siemens Immulite 2000 pg/ml 537 429 645 pmol/l 31.4 25.1 37.7 Roche Elecsys pg/ml 298 238 358 pmol/l 29.7 23.8 35.6 Roche Modular E170 pg/ml 282 226 338 pmol/l 57.6 46.1 69.1 Abbott Architect pg/ml 547 438 656 pmol/l 31.3 25.0 37.6 Roche Cobas E411 pg/ml 297 237 357 pmol/l 29.8 23.8 35.8 Roche Cobas 6000 pg/ml 283 226 340 pmol/l 34.0 26.6 41.4 Beckman DxI800 pg/ml 323 253 393 Phenobarbital µmol/l 121 96.6 145 Gravimetric µg/ml 28.0 22.4 33.6 Phenytoin µmol/l 82.5 66.0 99.0 Behring Emit µg/ml 20.8 16.7 24.9 µmol/l 81.8 65.4 98.2 Abbott AXSYM µg/ml 20.7 16.5 24.9 µmol/l 74.5 59.6 89.4 Vitros µg/ml 18.8 15.0 22.6 µmol/l 79.9 63.9 95.9 Siemens Immulite 1000 µg/ml 20.2 16.1 24.3 µmol/l 74.9 59.9 89.9 Roche Integra µg/ml 18.9 15.1 22.7 µmol/l 83.3 66.6 100 Abbott Architect µg/ml 21.0 16.8 25.2 µmol/l 84.4 67.5 101 Roche Modular P-D µg/ml 21.3 17.0 25.6 µmol/l 81.0 61.1 101 Roche Cobas 6000 µg/ml 20.5 15.4 25.6 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 11 OF 19

Phenytoin µmol/l 99.8 79.8 120 Gravimetric µg/ml 25.2 20.1 30.3 Primidone µmol/l 32.7 26.2 39.2 Gravimetric µg/ml 7.14 5.72 8.56 Progesterone nmol/l 114 91.2 137 Beckman Access ng/ml 35.7 28.5 42.9 nmol/l 101 75.8 126 Abbott AXSYM ng/ml 31.6 23.7 39.5 nmol/l 92.4 69.3 116 Siemens Immulite 1000 ng/ml 28.9 21.7 36.1 nmol/l 136 109 163 BioMerieux Vidas ng/ml 42.6 34.1 51.1 nmol/l 114 91.2 137 Roche Elecsys ng/ml 35.7 28.5 42.9 nmol/l 106 84.8 127 Vitros ECi ng/ml 33.2 26.5 39.9 nmol/l 71.9 51.0 92.8 Siemens Advia Centaur ng/ml 22.5 16.0 29.0 nmol/l 85.7 68.6 103 Siemens Immulite 2000/2500 ng/ml 26.8 21.5 32.1 nmol/l 95.4 76.3 114 Abbott Architect ng/ml 29.9 23.9 35.9 nmol/l 110 88.0 132 Roche Modular E170 ng/ml 34.4 27.5 41.3 nmol/l 104 83.2 125 Beckman DxI800 ng/ml 32.6 26.0 39.2 nmol/l 113 90.4 136 Roche Cobas E411 ng/ml 35.4 28.3 42.5 nmol/l 110 88.0 132 Roche Cobas 6000 ng/ml 34.4 27.5 41.3 Prolactin µu/ml 1016 813 1219 Beckman Access µu/ml 1195 956 1434 Abbott AXSYM µu/ml 1293 1034 1552 BioMerieux Vidas µu/ml 1058 846 1270 Siemens Immulite 1000 µu/ml 1332 1066 1598 Tosoh AIA360 µu/ml 1336 1069 1603 Roche Elecsys µu/ml 1103 882 1324 Vitros ECi µu/ml 1093 820 1366 Siemens Advia Centaur µu/ml 981 785 1177 Siemens Immulite 2000/2500 µu/ml 1404 1123 1685 Abbott Architect µu/ml 1215 972 1458 Diasorin Liaison µu/ml 1308 1046 1570 Roche Modular E170 µu/ml 1025 820 1230 Beckman DxI800 µu/ml 1311 1049 1573 Roche Modular E170 2nd Gen prolactin II µu/ml 1342 1074 1610 Roche Elecsys 2nd Gen. prolactin II µu/ml 1340 1072 1608 Roche Cobas E411 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 12 OF 19

Prolactin µu/ml 1276 1021 1531 Roche Cobas 6000 µu/ml 1777 1510 2044 Pishtaz Teb- ELISA PSA Free ng/ml = µg/l 13.0 9.75 16.3 Siemens Immulite 1000 ng/ml = µg/l 13.1 9.83 16.4 Siemens Immulite 2000/2500 ng/ml = µg/l 14.0 10.5 17.5 Abbott Axsym - monoclonal ng/ml = µg/l 14.9 11.2 18.6 Roche Elecsys ng/ml = µg/l 16.3 12.2 20.4 Abbott Architect ng/ml = µg/l 18.0 13.5 22.5 Beckman Access (Hybritech) ng/ml = µg/l 14.6 11.0 18.3 Siemens Advia Centaur ng/ml = µg/l 7.99 5.99 9.99 Diasorin Liaison ng/ml = µg/l 14.7 11.0 18.4 Roche Modular E170 ng/ml = µg/l 19.1 14.3 23.9 Beckman DxI800 ng/ml = µg/l 14.9 11.2 18.6 Roche Cobas E411 ng/ml = µg/l 14.6 11.0 18.3 Roche Cobas 6000 PSA Total ng/ml = µg/l 15.8 11.9 19.8 Abbott Axsym - monoclonal ng/ml = µg/l 17.7 12.9 22.5 Siemens Immulite 1000 1st generation ng/ml = µg/l 22.3 16.7 27.9 Roche Elecsys ng/ml = µg/l 15.9 11.9 19.9 Tosoh AIA360 ng/ml = µg/l 21.4 16.1 26.8 Beckman Access-non-standardised results ng/ml = µg/l 18.6 14.0 23.3 Siemens ADVIA Centaur (equimolar) ng/ml = µg/l 21.1 15.8 26.4 biomerieux VIDAS TPSA ng/ml = µg/l 18.8 14.1 23.5 Siemens Advia Centaur ng/ml = µg/l 15.0 11.3 18.8 Siemens Immulite 2000/2500 1st generation ng/ml = µg/l 17.6 13.2 22.0 Abbott Architect ng/ml = µg/l 15.7 11.8 19.6 Siemens Immulite 1000 3rd generation ng/ml = µg/l 16.4 12.3 20.5 Siemens Immulite 2000/2500 3rd generation ng/ml = µg/l 8.67 6.50 10.8 Vitros ECi ng/ml = µg/l 11.4 8.55 14.3 Diasorin Liaison ng/ml = µg/l 21.1 15.8 26.4 Roche Modular E170 ng/ml = µg/l 19.0 14.3 23.8 Siemens Dimension equimolar ng/ml = µg/l 23.8 17.9 29.8 Beckman Access standardised to IRP96/670 ng/ml = µg/l 22.6 17.0 28.3 Beckman DxI800 non-standardised ng/ml = µg/l 18.0 13.5 22.5 Beckman DxI800 standardised to IRP96/670 ng/ml = µg/l 21.7 16.3 27.1 Roche Cobas E411 ng/ml = µg/l 21.6 16.2 27.0 Roche Cobas 6000 ng/ml = µg/l 19.8 16.8 22.8 Pishtaz Teb- ELISA Salicylic Acid mmol/l 3.00 2.40 3.60 Vitros mg/dl 41.4 33.1 49.7 mmol/l 2.88 2.30 3.45 Gravimetric mg/dl 39.7 31.8 47.7 SHBG nmol/l 45.6 34.9 56.3 Siemens Immulite 2000/2500 nmol/l 44.3 35.4 53.2 Roche Elecsys nmol/l 43.7 35.0 52.4 Roche Modular E170 nmol/l 44.1 35.3 52.9 Roche Cobas E411 nmol/l 44.7 35.8 53.6 Roche Cobas 6000 nmol/l 48.6 38.9 58.3 Beckman DxI800 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 13 OF 19

T Uptake %U 44.1 36.2 52.0 Siemens Immulite 2000 %U 49.0 43.0 55.0 Pishtaz Teb- ELISA Testosterone nmol/l 35.6 26.4 44.8 Abbott AXSYM ng/ml 10.3 7.60 13.0 ng/dl 1025 760 1290 nmol/l 40.2 29.2 51.2 Siemens Immulite 1000 ng/ml 11.6 8.41 14.8 ng/dl 1158 841 1475 nmol/l 40.2 32.2 48.2 Vitros ECi ng/ml 11.6 9.27 13.9 ng/dl 1158 927 1389 nmol/l 26.3 19.2 33.4 Siemens Advia Centaur ng/ml 7.57 5.53 9.61 ng/dl 757 553 961 nmol/l 38.9 31.1 46.7 Siemens Immulite 2000/2500 ng/ml 11.2 8.96 13.4 ng/dl 1120 896 1344 nmol/l 34.4 27.5 41.3 Abbott Architect ng/ml 9.91 7.92 11.9 ng/dl 991 792 1190 nmol/l 43.9 35.1 52.7 BioMerieux Vidas ng/ml 12.6 10.1 15.1 ng/dl 1264 1011 1517 nmol/l 30.0 24.0 36.0 Roche Modular E170 Test II ng/ml 8.64 6.91 10.4 ng/dl 864 691 1037 nmol/l 30.0 24.0 36.0 Roche Cobas 6000 Test 2 ng/ml 8.64 6.91 10.4 ng/dl 864 691 1037 nmol/l 27.3 21.8 32.8 Beckman Access ng/ml 7.86 6.28 9.45 ng/dl 786 628 945 nmol/l 30.0 24.0 36.0 Roche Elecsys Test II ng/ml 8.64 6.91 10.4 ng/dl 864 691 1037 nmol/l 29.9 23.9 35.9 Roche Cobas 4000/e411 Test II ng/ml 8.62 6.88 10.3 ng/dl 862 688 1034 nmol/l 24.1 19.3 28.9 Beckman DxI800 ng/ml 6.94 5.56 8.32 ng/dl 694 556 832 Theophylline µmol/l 156 125 187 Abbott AXSYM µg/ml 28.1 22.5 33.7 µmol/l 166 133 199 Roche Integra µg/ml 29.9 24.0 35.8 µmol/l 157 126 188 Siemens Advia Centaur µg/ml 28.3 22.7 33.9 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 14 OF 19

Theophylline µmol/l 162 126 198 Abbott Architect µg/ml 29.2 22.7 35.7 µmol/l 168 134 202 Roche Cobas 6000 µg/ml 30.3 24.1 36.5 µmol/l 166 133 199 Gravimetric µg/ml 29.9 24.0 35.9 Thyroglobulin ng/ml 51.8 38.9 64.8 Siemens Immulite 1000 ng/ml 49.5 37.1 61.9 Siemens Immulite 2000 ng/ml 78.6 59.0 98.3 Roche Elecsys ng/ml 79.2 59.4 99.0 Roche Modular E170 ng/ml 72.7 54.5 90.8 Beckman DxI800 ng/ml 74.0 58.5 89.5 Roche Cobas E411 ng/ml 80.4 60.3 101 Roche Cobas 6000 Thyroid Stimulating µu/ml = mlu/l 19.3 14.9 23.7 Abbott Axsym Ultrasensitive htsh II Hormone µu/ml = mlu/l 21.1 16.9 25.3 biomerieux VIDAS TSH µu/ml = mlu/l 20.7 16.6 24.8 Siemens Immulite 1000 µu/ml = mlu/l 20.2 16.2 24.2 Roche Elecsys µu/ml = mlu/l 17.8 14.2 21.4 Beckman Access hypertsh 3rd Generation µu/ml = mlu/l 23.0 18.4 27.6 Tosoh AIA360 µu/ml = mlu/l 28.6 22.9 34.3 Vitros ECi µu/ml = mlu/l 20.1 13.7 26.5 Siemens Advia Centaur µu/ml = mlu/l 20.3 16.2 24.4 Siemens Immulite 2000/2500 µu/ml = mlu/l 18.0 14.4 21.6 Abbott Architect Ultrasensitive htsh II µu/ml = mlu/l 22.3 17.8 26.8 Diasorin Liaison µu/ml = mlu/l 20.2 16.2 24.2 Roche Modular E170 µu/ml = mlu/l 18.5 14.8 22.2 Beckman DxI800 µu/ml = mlu/l 16.8 13.4 20.2 Beckman DxI800 Fast TSH µu/ml = mlu/l 20.0 13.6 26.4 Siemens ADVIA Centaur 3rd Generation µu/ml = mlu/l 20.3 16.2 24.4 Roche Cobas E411 µu/ml = mlu/l 20.3 16.2 24.4 Roche Cobas 6000 µu/ml = mlu/l 18.6 14.9 22.3 Beckman DxI800 Hyper TSH µu/ml = mlu/l 21.7 16.3 27.1 Monobind Inc. ELISA µu/ml = mlu/l 26.5 23.0 30.0 Pishtaz Teb- ELISA Tobramycin µmol/l 10.3 8.20 12.3 Gravimetric µg/ml 4.80 3.84 5.76 Total Beta hcg mu/ml=iu/l 535 428 642 Abbott AXSYM IU/ml 0.535 0.428 0.642 mu/ml=iu/l 522 418 626 BioMerieux Vidas IU/ml 0.522 0.418 0.626 mu/ml=iu/l 609 462 756 Siemens Immulite 1000 IU/ml 0.609 0.462 0.760 mu/ml=iu/l 479 383 575 Roche Elecsys HCG + Beta IU/ml 0.479 0.383 0.575 mu/ml=iu/l 401 321 481 Beckman Access IU/ml 0.401 0.321 0.481 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 15 OF 19

Total Beta hcg mu/ml=iu/l 544 435 653 Vitros ECi IU/ml 0.544 0.435 0.653 mu/ml=iu/l 372 223 521 Siemens Advia Centaur IU/ml 0.372 0.223 0.521 mu/ml=iu/l 661 529 793 Siemens Immulite 2000 IU/ml 0.661 0.529 0.793 mu/ml=iu/l 412 330 494 Abbott Architect IU/ml 0.412 0.330 0.494 mu/ml=iu/l 466 373 559 Roche Modular E170 IU/ml 0.466 0.373 0.559 mu/ml=iu/l 383 306 460 Beckman DxI800 IU/ml 0.383 0.306 0.460 mu/ml=iu/l 428 310 546 Roche Elecsys HCG STAT Intact IU/ml 0.428 0.310 0.550 mu/ml=iu/l 478 382 574 Roche Cobas E411 IU/ml 0.478 0.382 0.574 mu/ml=iu/l 470 376 564 Roche Cobas 6000 IU/ml 0.470 0.376 0.564 mu/ml=iu/l 273 215 331 Pishtaz Teb- ELISA IU/ml 0.273 0.215 0.331 Total T3 nmol/l 7.51 5.63 9.39 Abbott AXSYM ng/ml 4.89 3.67 6.11 ng/dl 489 367 611 nmol/l 6.17 4.63 7.71 BioMerieux Vidas ng/ml 4.02 3.01 5.03 ng/dl 402 301 503 nmol/l 6.50 4.88 8.13 Siemens Immulite 1000 ng/ml 4.23 3.18 5.28 ng/dl 423 318 528 nmol/l 6.66 5.00 8.33 Roche Elecsys ng/ml 4.34 3.26 5.42 ng/dl 434 326 542 nmol/l 6.46 4.85 8.07 Beckman Access ng/ml 4.21 3.16 5.26 ng/dl 421 316 526 nmol/l 7.59 5.69 9.49 Siemens Advia Centaur ng/ml 4.94 3.70 6.18 ng/dl 494 370 618 nmol/l 6.26 4.70 7.83 Siemens Immulite 2000/2500 ng/ml 4.08 3.06 5.10 ng/dl 408 306 510 nmol/l 5.33 4.00 6.66 Abbott Architect ng/ml 3.47 2.60 4.34 ng/dl 347 260 434 nmol/l 7.84 5.88 9.80 Vitros ECi ng/ml 5.10 3.83 6.37 ng/dl 510 383 637 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 16 OF 19

Total T3 nmol/l 6.45 4.84 8.06 Roche Modular E170 ng/ml 4.20 3.15 5.25 ng/dl 420 315 525 nmol/l 6.57 4.93 8.21 Beckman DxI800 ng/ml 4.28 3.21 5.35 ng/dl 428 321 535 nmol/l 6.88 5.16 8.60 Roche Cobas E411 ng/ml 4.48 3.36 5.60 ng/dl 448 336 560 nmol/l 6.43 4.82 8.04 Roche Cobas 6000 ng/ml 4.19 3.14 5.24 ng/dl 419 314 524 nmol/l 4.82 4.21 5.43 Pishtaz Teb- ELISA ng/ml 3.15 2.75 3.55 ng/dl 315 275 355 Total T4 nmol/l 211 158 264 Vitros ECi µg/dl 16.5 12.3 20.7 ng/ml 165 123 207 nmol/l 209 157 261 Abbott AXSYM µg/dl 16.3 12.2 20.4 ng/ml 163 122 204 nmol/l 199 149 249 BioMerieux Vidas µg/dl 15.5 11.6 19.4 ng/ml 155 116 194 nmol/l 224 168 280 Siemens Immulite 1000 µg/dl 17.5 13.1 21.9 ng/ml 175 131 219 nmol/l 184 138 230 Roche Elecsys µg/dl 14.4 10.8 18.0 ng/ml 144 108 180 nmol/l 218 153 283 Siemens Advia Centaur µg/dl 17.0 11.9 22.1 ng/ml 170 119 221 nmol/l 194 146 243 Siemens Immulite 2000/2500 µg/dl 15.1 11.4 18.8 ng/ml 151 114 188 nmol/l 237 178 296 Abbott Architect µg/dl 18.5 13.9 23.1 ng/ml 185 139 231 nmol/l 177 133 221 Roche Modular E170 µg/dl 13.8 10.4 17.2 ng/ml 138 104 172 nmol/l 206 155 258 Beckman DxI800 µg/dl 16.1 12.1 20.1 ng/ml 161 121 201 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 17 OF 19

Total T4 nmol/l 188 141 235 Roche Cobas E411 µg/dl 14.7 11.0 18.4 ng/ml 147 110 184 nmol/l 181 136 226 Roche Cobas 6000 µg/dl 14.1 10.6 17.6 ng/ml 141 106 176 nmol/l 226 194 258 Pishtaz Teb- ELISA µg/dl 17.6 15.1 20.1 ng/ml 176 151 201 Valproic Acid µmol/l 936 749 1123 Abbott AXSYM µg/ml 135 108 162 µmol/l 1027 822 1232 Siemens Immulite 1000 µg/ml 148 119 177 µmol/l 942 754 1130 Roche Integra µg/ml 136 109 163 µmol/l 1002 802 1202 Siemens Immulite 2000/2500 µg/ml 145 116 174 µmol/l 927 742 1112 Siemens Advia Centaur µg/ml 134 107 161 µmol/l 936 749 1123 Vitros µg/ml 135 108 162 µmol/l 878 702 1054 Siemens Dimension µg/ml 127 101 153 µmol/l 940 752 1128 Abbott Architect µg/ml 136 109 163 µmol/l 944 755 1133 Roche Cobas 6000 µg/ml 136 109 163 µmol/l 1116 893 1339 Gravimetric µg/ml 161 129 193 Vancomycin µmol/l 9.98 7.98 12.0 Ortho Vitros Microslide Systems µg/ml 14.8 11.9 17.7 µmol/l 10.9 8.72 13.1 Abbott Architect µg/ml 16.2 13.0 19.4 µmol/l 10.8 8.64 13.0 Gravimetric µg/ml 16.0 12.8 19.3 Vitamin B12 pmol/l 806 616 996 Abbott AXSYM pg/ml 1092 835 1349 pmol/l 898 718 1078 Roche Elecsys pg/ml 1217 973 1461 pmol/l 908 726 1090 Beckman Access pg/ml 1230 984 1476 pmol/l 878 702 1054 Siemens Immulite 1000 pg/ml 1190 951 1429 pmol/l 962 722 1202 Siemens Advia Centaur pg/ml 1304 978 1630 pmol/l 736 589 883 Siemens Immulite 2000 pg/ml 997 798 1196 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 18 OF 19

Vitamin B12 pmol/l 969 775 1163 Abbott Architect pg/ml 1313 1050 1576 pmol/l 720 576 864 Vitros ECi pg/ml 976 780 1172 pmol/l 924 739 1109 Roche Modular E170 pg/ml 1252 1001 1503 pmol/l 829 663 995 Beckman DxI800 pg/ml 1123 898 1348 pmol/l 883 706 1060 Roche Cobas E411 pg/ml 1196 957 1435 pmol/l 924 739 1109 Roche Cobas 6000 pg/ml 1252 1001 1503 RANDOX Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY PAGE 19 OF 19