It s time to take care of T-Cell Lymphomas



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INSTITUTE OF HEMATOLOGY AND ONCOLOGY L. AND A. SERÀGNOLI Presidents: Michele Baccarani Stefano Pileri Pier Luigi Zinzani Honorary President: Sante Tura PROGRAM Bologna, October 22-24, 2006

SIE Scientific Committee Sergio Amadori President Emanuele Angelucci Paolo Corradini Mario Lazzarino Francesco Lo Coco Gina Zini Pier Luigi Zinzani Alma Mater Studiorum Università di Bologna Scientific Secretariat Monica Tani, Elena Sabattini Istituto di Ematologia ed Oncologia Medica L. e A. Seràgnoli - Via Massarenti, 9 40138 Bologna, Italy Tel. +39 051 6363680 - Fax +39 051 6364037 Organizing Secretariat Studio E.R. Congressi - Gruppo Triumph Via Marconi, 36-40122 Bologna, Italy Tel. +39 051 4210559 - Fax +39 051 4210174 e-mail: ercongressi@gruppotriumph.it www.ercongressi.it Bologna, October 22-24, 2006 Presidents: Michele Baccarani Stefano Pileri Pier Luigi Zinzani Honorary President: Sante Tura Auspices MINISTERO DELLA SALUTE UNIVERSITÀ DEGLI STUDI DI BOLOGNA REGIONE EMILIA ROMAGNA ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE - LINFOMI E MIELOMA SEZIONE DI BOLOGNA Faculty: Sergio Amadori Roma, Italy Agustin Aviles Mexico City, Mexico Michele Baccarani Bologna, Italy Susan Bates Bethesda, USA Emilio Berti Monza, Italy Bruce Cheson Washington, USA Teodoro Chisesi Venezia, Italy Paolo Corradini Milano, Italy Romano Danesi Pisa, Italy Francesco D Amore Arhus, Denmark Fabrizio De Ponti Bologna, Italy Reinhard Dummer Zurich, Switzerland Madeleine Duvic Houston, USA Brunangelo Falini Perugia, Italy Francine Foss New Haven, USA Richard Furman New York, USA Gianluca Gaidano Novara, Italy Varsha Gandhi Houston, USA Philippe Gaulard Creteil, France Christian Gisselbrecht Paris, France Steven Horwitz New York, USA Elaine Jaffe Bethesda, USA John Janik Bethesda, USA Michael J. Keating Houston, USA Mario Lazzarino Pavia, Italy Raymond Liang Hong Kong - China Ying-Wei Lin Nara, Japan Maurizio Martelli Roma, Italy Enrica Morra Milano, Italy Owen O Connor New York, USA Francesco Onida Milano, Italy Fabrizio Pane Napoli, Italy Marco Paulli Pavia, Italy Stefano Pileri Bologna, Italy Nicola Pimpinelli Firenze, Italy William Plunkett Houston, USA Pierluigi Porcu Columbus, USA Stephen John Proctor Newcastle, UK Peter Reimer Wurzburg, Germany Damiano Rondelli Chicago, USA Steven Rosen Chicago, USA Thomas Ruediger Wurzburg, Germany Marco Santucci Firenze, Italy Monica Tani Bologna, Italy Corrado Tarella Torino, Italy Kensei Tobinai Tokyo, Japan Giuseppe Torelli Modena, Italy Lorraine Tracey Memphis, USA Umberto Vitolo Torino, Italy Julie M. Vose Omaha, USA Dennis D. Weisenburger Omaha, USA Sean Whittaker London, UK Rein Willemze Leiden, The Netherlands Uwe Wollina Dresden, Germany Pier Luigi Zinzani Bologna, Italy

4 5 October 22, 2006 2.30 p.m. Welcome and Introduction 2.45 p.m. State of the Art on T-cell lymphomas: Chairmen: S. Amadori, G. Torelli Epidemiology R. Liang Pathogenesis E. Jaffe Conventional treatment of PTCL: the European perspective - C. Gisselbrecht the US perspective - J. Vose the Asian perspective - K. Tobinai the Caribbean perspective - A. Aviles Conventional treatment of CTCL S.Whittaker 5.45 p.m. PTCL: Morphology and Biology Chairmen: G. Gaidano, F. Pane Histology P. Gaulard Molecular Biology T. Ruediger Gene Expression Profiling S. Pileri

October 23, 2006 6 7 8.30 a.m. PTCL: Innovative Treatments Histone deacetylase inhibitors Chairmen: O.A. O'Connor, U. Vitolo HDACI and SAHA phase I-II data O.A. O'Connor Depsipeptide S. Bates MS-275 P. Porcu 10.00 a.m. Coffee Break 10.15 a.m. Monoclonoal antibodies and others Chairmen: M. Martelli, E. Morra Campath-1H F. D'Amore Anti-CD30 S.J. Proctor BCX-1777 (Forodesine): preclinical data - V. Gandhi clinical data - R. Furman Praletrexate O.A. O'Connor 1.30 p.m. Lunch CTLA4 receptor J.E. Janik Clofarabine S. Horwitz Linalidomide S. Rosen Nelarabine M.J. Keating Other new new drugs B. Cheson 2.30 p.m. CTCL: Morphology and Biology Chairmen: B. Falini, M. Paulli Histology M. Santucci Molecular Biology E. Berti Gene Expression Profiling L. Tracey 3.45 p.m. Coffee Break

8 9 October 24, 2006 4.00 p.m. CTCL: Innovative Treatments Chairmen: M. Lazzarino, U. Vitolo Campath-1H S. Rosen HuMax-CD4 F. D'Amore Ontak M. Duvic Gemcitabine M. Tani Pegylated Liposomal Doxorubicin U. Wollina Interferon R. Dummer Bexarotene M. Duvic Bortezomib P.L. Zinzani Other new new drugs F. Foss 8.30 a.m. From Mouse Models to Prognostic Factors Chairmen: R. Danesi, F. De Ponti LECTURE: Animals models of T-cell lymphomas Ying-Wei Lin LECTURE: Why the same drugs are active in B-cell and not in T-cell lymphomas? W. Plunkett Prognostic Factors: PTCL D.D. Weisenburger CTCL R. Willemze When and which aggressive treatment? Chairmen: D. Rondelli, C. Tarella Chemotherapy in PTCL J. Vose Chemotherapy in CTCL N. Pimpinelli

10 Autotransplant in PTCL P. Reimer Allotransplant in PTCL P. Corradini Auto and Allotransplant in CTCL F. Onida Bologna, October 22-24, 2006

GENERAL INFORMATION Meeting venue Via Montebello, 8-40121 Bologna, Italy Phone +39 051 249361 - Fax +39 051 249724 12 13 TRAVEL AGENCY Bononia Viaggi Piazza Martiri, 1-40122 Bologna Italy Phone +39-051 4211585 Fax +39-051 249846 congressi@bononiaviaggi.it HOW TO GET THERE By car From the motorway, turn into the ring road ("Tangenziale") - Exit 7 Fiera and follow direction city center and railway station. By taxi From the airport about 30 minutes. By bus Bus 91 and Aerobus from the airport. From the railway station walking distance. OFFICIAL LANGUAGE English. REGISTRATION FEE Euro 350,00 The registration fee includes: Conference kit Partecipation in the scientific sessions Proceedings Book Attendance Certificate Coffee breaks Lunch REGISTRATION: Registrations can only be accepted and confirmed after the registration form and fee have been received by the Organizing Secretariat, Studio E.R. Congressi. All payments must be done in Euro net of all bank charges and made out to Studio E.R. Congressi S.r.l. Please pay by: HOTEL RESERVATION Category Double Single Use Double MIN. MAX. MIN. MAX. 4 STARS Euro 125,00 Euro 185,00 Euro 155,00 Euro 225,00 3 STARS Euro 114,00 Euro 124,00 Reservation fee, 20,00 per room. Prices are inclusive of tax service and breakfast, per room per night. Please fill in the hotel reservation form and send it to the official travel agency Bononia Viaggi before September 30th, 2006. Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room in the selected hotel category plus 20,00 for agency rights) have been received by Bononia Viaggi. Payments must be done in Euro net of all bank charges and made out to Bononia Viaggi S.r.l. Please pay by: * Eurocheque or Foreign Cheque * Bank transfer made out to Bononia Viaggi S.r.l. - Account n 9000/2 - Cassa di Risparmio di Bologna Filiale S. Giuseppe, Via Saragozza 87, 40135 Bologna BO Italy - ABI 6385 - CAB 02418 * Credit card Please send a copy of the bank transfer with the hotel reservation form. In case of written cancellation before September 30th, 2006, 80% of the fee will be refunded. * Eurocheque or Foreign Cheque * Bank transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna I Swift code: CECRIT 2C - Iban code: IT 36J 0612002400246000000002596 - ABI 06120 - CAB 02400 Account n 000000002596 * Credit Card Please send a copy of the bank transfer with the registration form. In case of written cancellation before August 31st, 2006, 80% of the registration fee will be refunded.

SCIENTIFIC INFORMATION 14 REGISTRATION FORM Please, return this form to: Studio E.R. Congressi - Via Marconi 36 40122 Bologna BO Italy Phone +39-051 4210559 Fax +39-051 4210174 ercongressi@gruppotriumph.it Bologna, October 22-24, 2006 Slides Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. LAST NAME FIRST NAME Badge All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. ISTITUTION /DEPARTMENT Attendance certificate A certificate will be given to all participants at the end of the Meeting. PROFESSION Ecm Application for ECM credits and ECAH CME credits will be made. DISCIPLINE ADDRESS STATE/PROVINCE Changes Parts of the programme may be changed if necessary. ZIP CITY COUNTRY TELEPHONE FAX MOBILE PHONE E-MAIL FOR THE INVOICE: LAST NAME FIRST NAME PRIVATE ADDRESS CITY STATE/PROVINCE ZIP COUNTRY VAT NUMBER (P. IVA) TAX PAYER S NUMBER (COD. FISCALE)

REGISTRATION FORM REGISTRATION FEE (in Euro - VAT included): Euro 350,00 HOTEL RESERVATION FORM Bononia Viaggi Piazza Martiri, 1 40122 Bologna Italy Phone +39-051 4211585 Fax +39-051 249846 congressi@bononiaviaggi.it Bologna, October 22-24, 2006 PAYMENT I enclose Eurocheque or Foreign Cheque LAST NAME FIRST NAME of Euro Bank made out to Studio E.R. Congressi S.r.l. Number INSTITUTION Bank Transfer made out to Studio E.R. Congressi S.r.l. CASSA DI RISPARMIO DI CESENA - Agenzia n 29, Largo Caduti del Lavoro 1/A, Bologna I Swift code: CECRIT 2C - Iban code: IT 36J 0612002400246000000002596 - ABI 06120 - CAB 02400 Account n 000000002596 Credit Card: Number Expiry date Owner Date of birth VISA MASTERCARD DINERS AMERICAN EXPRESS I enclose a copy of the bank transfer with the registration form. Registrations can only be accepted and confirmed when the registration form and fee have been received by the Organizing Secretariat Studio E.R. Congressi. In case of written cancellation before August 31st, 2006, 80% of the registration fee will be refunded. Signing this form and well informed on the Legislative Decree n. 196/2003 concerning Personal data processing, I authorize Bononia Viaggi S.r.l., until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I give my assent provided that Bononia Viaggi complies with the regulations in force. I do not want that my personal data are divulged to third parties. ADDRESS CITY ZIP TELEPHONE E-MAIL FOR THE INVOICE: PRIVATE ADDRESS CITY ZIP TELEPHONE VAT NUMBER (IVA) STATE/PROVINCE COUNTRY FAX STATE/PROVINCE COUNTRY DATE SIGNATURE TAX PAYER S NUMBER (COD. FISCALE) NAME OF THE ACCOMPANYING PERSON

INFORMATION ON LEGISLATIVE DECREE N. 196/2003 HOTEL RESERVATION FORM HOTEL RESERVATION Category Double Single Use Double MIN. MAX. MIN. MAX. 4 STARS Euro 125,00 Euro 185,00 Euro 155,00 Euro 225,00 3 STARS Euro 114,00 Euro 124,00 These prices are per night per room and include bed, breakfast and taxes. Reservation fee, 20,00 HOTEL RESERVATION 4 stars 3 stars Double Double Single Use Date of arrival In case of double room, indicate the name of your room-mate Date of departure PAYMENT I enclose Eurocheque or Foreign Cheque of: Euro Number Bank made out to Bononia Viaggi S.r.l. Bank Transfer made out to Bononia Viaggi S.r.l. - Account n 9000/2 - Cassa di Risparmio di Bologna Filiale S. Giuseppe, Via Saragozza 87, 40135 Bologna Italy - ABI 6385 - CAB 02418 Credit Card: Number Expiry date Owner Date of birth VISA MASTERCARD DINERS AMERICAN EXPRESS I enclose a copy of the bank transfer with the hotel reservation form. Hotel reservation can only be accepted and confirmed when the form and the confirmatory deposit (the price of one night per room in the selected hotel category plus Lit. Euro 12.91 for agency rights) have been received by Bononia Viaggi. In case of written cancellation before August 31st, 2006, 80% will be refunded. Signing this form and well informed on the Legislative Decree n. 196/2003 concerning Personal data processing, I authorize Bononia Viaggi S.r.l., until written revocation, to process and divulge my personal data within the limits of the above-mentioned law and in accordance with the procedure laid down by the law. I give my assent provided that Bononia Viaggi complies with the regulations in force. I do not want that my personal data are divulged to third parties. DATE SIGNATURE According to art. 13, Legislative decree no. 196/2003, and in relation to the processing of personal data, Studio E.R. Congressi S.r.l inform you of the following: l. Data processing purposes Your personal data will be processed by Studio E.R. Congressi S.r.l for managing, accounting, statistical, commercial, marketing and/or promoting purposes and this by processing, comparing, divulging or employing these very data. 2. Data Processing modality Data will be processed by appropriate devices ensuring their security and confidentiality. Data could be also processed by automatic machines employed to process, store and transmit the very data. 3. Obligatoriness of personal data bestowal To be registered in the congresses we organize, you are obligated to give your data. 4. Data communication, diffusion and transfer Your data can be given to organizers of the congress and to the companies sponsoring the event as well as to other companies, authorities, consortia or associations that could divulge these data to their members, users and other related people within the limits of their institutional purposes. The only objective is to inform the person concerned about the existence of similar initiatives or to supply him with other information that could be deemed interesting. Furthermore, the above mentioned data can be given/divulged to companies, authorities, consortia and association working in Italy or in the EC countries having the same objectives as stated before. 5. Rights of interested parties You have the right to know, consulting the register specified in the art. 154 sub-section 1 letter l) of the legislative decree 196/2003, the existence of data processing; you can partially or entirely oppose, for legitimate reasons, the processing of your data, even if these data are relevant to the objective of data collection. Furthermore you can prevent his data from being used for commercial purposes, market surveys, advertisement for direct selling or interactive commercials. You are acknowledged exercise of rights as per art. 7, Legislative decree 196/2003, the complete text of which is given in the enclosure. 6. The owner of the data processing The owner of the data processing is Studio E.R. Congressi S.r.l Via Marconi, 36-40122 Bologna. The list of the people responsible of the processing itself is kept updated, and you can easily consult it sending a written communication to the above address. Data will be held into the Studio E.R. Congressi S.r.l building, as long as the law prescribes. Article 7 of the legislative decree 196/2003 - right of access to personal data and other rights 1. The person concerned has the right to obtain confirmation of the existence of personal data and information regarding him/her - even though not recorded yet - and their disclosure under an intelligible form. 2. The person concerned is entitled to be informed of: a) the origin of personal data and information; b) data treatment purposes and ways; c) the logic followed in the event of data treatment being carried out with electronic tools; d) the details to identify the owner, the persons in charge and the representative appointed under article 5, paragraph 2; e) the people or groups of people to whom personal data and information can be disclosed or who may come to know them in their capacity as representative appointed in the State territory or persons in charge. 3. The person concerned has the right to obtain: a) updating, correction or - where interested in this process - supplementation of data; b) cancellation, turning into anonymous data or the block of data treated by infringing the law, including data and information which need not be kept in relation to the purposes for which data and information were collected or subsequently treated; c) a certificate stating that the operations under sub-paragraphs a) and b) - including their content - have been communicated to those to whom data and information were provided or disclosed, except the case when this proves to be impossible or entails the use of such an amount of means which is overtly non commensurate with the right which is protected. 4. The person concerned has to right to wholly or partially refuse: a) treatment of personal data and information regarding him/her for legitimate reasons, even though they are relevant to the aim of collection; b) treatment of personal data regarding him/her for the purposes of sending advertising material, direct sale or performance of market studies or commercial communications.

Scientific Secretariat Monica Tani, Elena Sabattini Istituto di Ematologia ed Oncologia Medica L. e A. Seràgnoli - Via Massarenti, 9 40138 Bologna, Italy Tel. +39 051 6363680 - Fax +39 051 6364037 Organizing Secretariat Studio E.R. Congressi - Gruppo Triumph Via Marconi, 36-40122 Bologna, Italy Tel. +39 051 4210559 - Fax +39 051 4210174 e-mail: ercongressi@gruppotriumph.it www.ercongressi.it www.struchel.com