IDBS Platform Software Compatibility and Support Information

Enabling Science IDBS Platform Software Compatibility and Support Information 30 September 2015 ID Business Solutions www.idbs.com

Information in this document is subject to change without notice. The software described in this document is furnished under a license agreement or nondisclosure agreement. The software may be used or copied only in accordance with the terms of those agreements. All rights reserved. o part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or any means electronic or mechanical, including photocopying and recording for any purpose other than the purchaser s personal use without the written permission of IDBS. The names of actual companies and products mentioned in this document may be trademarks of their respective owners. IDBS accepts no responsibility or liability for any errors or inaccuracies that may appear in this documentation. ID Business Solutions Confidential 2 of 27

Contents Introduction Product Support Lifecycle General Platform Support Citrix/Terminal Server Support Virtualisation Support Symyx Direct Chemistry Support E-WorkBook 10 Load Balancer Support Page 4 Page 4 Page 4 Page 5 Page 6 Page 6 Page 6 E-WorkBook Page 7 Desktop Client Page 7 Web Client Page 8 Application Servers Page 9 Database Server InforSense for E-WorkBook Page 10 Page 11 IDBS Hubs Page 12 ActivityBase Suite ActivityBase XE SARview SARgen Reporter XLfit IDBS Chemistry ActivityMart PredictionBase InforSense ClinicalSense ChemSense Biomolecular Hub for InforSense Quantrix Page 13 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 ID Business Solutions Confidential 3 of 27

Introduction This document summarises the levels of support that IDBS currently provide for its products in different software environments. It also indicates version compatibility between key IDBS products. The IDBS Support policy for its products is defined below. Support information can be found in the Customer Support Charter using the link below. Customer Support Charter Support levels for all product versions are defined as one of the following. Key Support Level Description The defined configuration has been fully tested by IDBS as part of the Product Release process. Any reported issue will be processed by IDBS Support, where the IDBS Supported Configuration Product is still within the supported timeframe (see Product Lifecycle Support below) C Certified The defined web browser has been fully tested by IDBS as part of the Product Release process. For further details relating to specific web browser support please refer to the IDBS Web Browser Support Information statement ot Supported The defined configuration has not been tested at IDBS and this environment may not even be available for any issue investigation. It will not be possible for IDBS Support to investigate any reported issues using this configuration S Special Support ot explicitly tested at IDBS, but Help Desk support and fixes/workarounds will be provided where possible /A ot Applicable This configuration does not exist e.g. 2000 Server 64 Bit TBA To be Announced Support is likely to be provided for this platform in the future, but no date for this has currently been set Product Support Lifecycle IDBS are committed to providing support for all active versions of released software, i.e. those on Full and Extended support. Products will however reach the end of their supported lifespan as new versions are released. The standard support policy is to provide Full Support for the superseded version for a minimum period of 2 years. After Full Support expires, the product version will be supported with Extended Support for a further 6 months. Full Support All calls to the Help Desk will be dealt with, including logging of enhancement requests, and defect fixes that will be considered for the next service release or the next product version, where possible. Extended Support The Help Desk will answer general questions and assist with providing workarounds to problems. o service releases for these versions will be released. Out of Support The Help Desk may no longer have access to this software version and may be unable to assist with any problems or questions. Such issues may be referred to an Account Manager. General Platform Support XP Professional Edition is Tested at IDBS. It cannot be guaranteed that other editions will function as expected. Vista Business Edition is Tested at IDBS. It cannot be guaranteed that other editions will function as expected. 7 Support is for Professional, Enterprise or Ultimate Editions. It cannot be guaranteed that other editions will function as expected. Please note that for ActivityBase, SARgen and XLfit mixed MS Office environments e.g. Office 2003 and 2007 are not supported for the same IDBS product installation. Office 365 support is limited to the use of the Office desktop client and not Office Web Apps. This document will therefore only reference the supported desktop client for this product, Office 2013. All IDBS Development and Testing is performed with only a single version of the IDBS software installed. Attempting to use multiple versions at the same time is not supported by IDBS and should any issues be encountered it will be requested that only a single software version is installed. IDBS support the latest service pack unless otherwise stated. Customers are recommended to upgrade to the latest patch set for maximum stability. ID Business Solutions Confidential 4 of 27

IDBS support the latest Microsoft Office service pack unless otherwise stated. Customers are recommended to upgrade to the latest patch set for maximum stability. IDBS support the latest Oracle patch set for each major version unless otherwise stated. Customers are recommended to upgrade to the latest patch set for maximum stability. Standard Edition One, Standard and Enterprise editions of Oracle are supported with the exception of ActivityMart which is only supported on Enterprise Edition. For each Oracle client installation you should ensure that the Oracle LS_LAG parameter matches that of the database. To find out what character set, language, or version of Oracle you are currently using, the following query should be executed in SQL Plus: SELECT A.VALUE FROM LS_DATABASE_PARAMETERS A WHERE A.PARAMETER= LS_UMERIC_CHARACTERS ; This should be compared to the Oracle Client settings. This can be determined by executing the following query in SQL Plus: SELECT A.VALUE FROM LS_SESSIO_PARAMETERS A WHERE A.PARAMETER= LS_UMERIC_CHARACTERS ; The results of both these queries should be the same. The client workstation Regional Settings should match those of the Oracle Client Settings i.e. if the Oracle decimal separator is set as. then this should be the same within the Regional options. Failure to do this can result in numeric data corruption. For client applications running on 7, 8 and Vista, all development and testing at IDBS is performed when User Account Control (UAC) configured to the lowest setting. If experiencing problems please disable this feature. Platform support details always relate to the latest service release of the IDBS product unless otherwise indicated. All IDBS Software Development and Testing is performed using the Groups "Administrators" followed by "Users". This ensures on-admininstrative Users can successfully use IDBS Software. The "Users" group is used as per Microsoft recommendations for running applications. Customer specific User Groups must be validated by the customer and IDBS does not take responsibility for the configuration or testing of these. Citrix/Terminal Server Support Where applicable, Citrix Terminal Server Full Support is limited to the following configurations: Configuration 1 Configuration 4 Citrix Presentation Server 4.0 x32 (with all recommended hot fixes applied) Citrix XenApp Server 6.5 (with all recommended hot fixes applied) 2003 Server 32 Bit SP2 2008 Server R2 64 Bit SP1 Microsoft Office 2003 SP2 Microsoft Office 2007 SP2 Oracle Client 10.2.0.x Oracle Client 11.2.0.x Configuration 2 Configuration 5 Citrix XenApp Server 5.0 x32 (with all recommended hot fixes applied) Citrix XenApp Server 6.5 (with all recommended hot fixes applied) 2003 Server 32 Bit SP2 2008 Server R2 64 Bit SP1 Microsoft Office 2007 SP2 Microsoft Office 2013 Oracle Client 10.2.0.x Oracle Client 11.2.0.x Configuration 3 Citrix XenApp Server 6.0 (with all recommended hot fixes applied) 2008 Server R2 64 Bit SP1 Microsoft Office 2007 SP2 Oracle Client 11.2.0.x When using Citrix it is necessary to ensure that all IDBS Applications are published ensuring that Session Sharing is set correctly due to applications calling others e.g. SARgen and SARview. For details on Citrix Session Sharing please refer to the following Citrix article: Citrix Knowledge Center Document ID CTX159159 Troubleshooting and Explaining Session Sharing ID Business Solutions Confidential 5 of 27

The Result Writing Component (RWC) server for ActivityBase 7.x is not currently supported when run on the same 2003 server as the Citrix Server. IDBS do not support Terminal Server with any of their products. Virtualisation Support Software virtualisation, such as VMWare is supported by IDBS according to a standard set of definitions. This includes running emulators such as VM Fusion for Macs. These can be found in the following document: IDBS Virtualisation Support Information Symyx Direct Chemistry Support This is the support policy for IDBS products that make connections to the Symyx Direct chemistry data cartridge. IDBS will support customers who run IDBS products that make connections with Symyx Direct versions 5.1 and above. However, IDBS may not be able to recreate the exact client environment with respect to the Symyx Direct version. Investigation of problems that may, in the sole opinion of IDBS be related to connection to Symyx Direct, will be handled as follows: 1) IDBS will provide standard support to all IDBS products 2) If a problem is encountered, the client may be required to assist IDBS in locating the cause of the issue by recreating and troubleshooting the problem on the client installation 3) If a defect is confirmed and a fix is provided, IDBS may request the client to assist in confirmation of the fix E-WorkBook 10 Load Balancer Support IDBS has tested E-WorkBook against the commercially available load balancer product ginx Plus and has made available a document describing how this product was configured for this testing. However, this does not constitute an endorsement of this or any other third-party load balancing product. For issues suspected of being related to the load balancing technology in place, IDBS will provide support on the basis of reasonable endeavours, but reserves the right to require customers to reconfigure their E- WorkBook deployment to bypass such third-party technology to eliminate or isolate this as the root cause. IDBS expects customers making use of load balancers to have entered into a technical support contract with a suitable third party to obtain assistance with technical issues relating to this technology. IDBS is willing to work with customer-contracted third-parties to resolve issues involving the interaction of E-WorkBook and load-balancing technology. For further information, please see E-Workbook White Paper - Load Balancer Configuration on the Customer Support Portal. ID Business Solutions Confidential 6 of 27

Client Operating System E-WorkBook Desktop Client MS Office ¹ Citrix Support Language Support XP Vista 7 8 10 2003 2007 2010 2013 32Bit 2 64Bit 32Bit 2 64Bit 32Bit 2 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 64Bit 32Bit 64Bit 9.2.x 9.3.x 9.4.0 9.4.1-9.4.3 10.0.x 10 11 12 13 14 15 2.1-2.4 2.5 3.2 3.3 4.0 4.1 5.7.1 5.7.2 6.0 Viewer Full Viewer Full Viewer Full Viewer Full Viewer Full 9.2.x S S 9.3.x S S 9.4.x S S 10.0.x S S 8.0.x 8.1.x 8.3.x 8.4.x 8.0.x - 8.1.x 8.3.x - 8.4.x 9.2.x /A 9.3.x /A 9.4.x /A 3 10.0.x /A General otes E-WorkBook Desktop Client - Third Party Software Compatibility Chemistry Drawing Packages Prism Support ChemDraw ISIS Draw Symyx Draw Accelrys Draw Marvin Sketch 5.02 5.03 5.04 6.03 6.05 E-WorkBook IDBS Compatibility ActivityBase Chemistry Registration Results 8 support refers to 8.1 for all versions, except E-Workbook 9.4.0 which is supported on 8.0 only. 3.3.0-3.3.1 ActivityMart 3.3.2-3.3.3 3.3.4 InforSense otes 1 For Office Support with E-WorkBook Suite the following documents types are tested and supported for document insert, display pages functionality and inclusion of the document within PDFs: Word, Excel and PowerPoint. The other documents within MS Office may be captured by E-WorkBook Suite but the inclusion of these documents in Page Previews and within PDFs has not been explicitly tested by IDBS. E-WorkBook 9.2.x support for ActivityMart 3.3.2 and above is limited to versions 9.2.0 to 9.2.3. For later versions of E-WorkBook 9.2.x, ActivityMart must be patched to version 3.3.3.1. 3 E-Workbook 9.4.x support is limited to ActivityMart 3.3.4 and E-WorkBook 9.4.2. Please note that catalog inheritence and the Asset Hub are not supported. 1.0.x 1.1.x 2016 Conf. 3 Conf. 4 Conf. 5 European O/S & MS Office Japanese O/S & MS Office 2 Whilst the E-WorkBook Suite client is supported on 32 bit, IDBS recommends that customers use 64 bit with the E-WorkBook 64-bit client so that more memory can made available to the application. This will result in better performance and capabilities especially when handling large files. If a 32 bit is used to capture large files customers may experience issues. For ActivityBase Compatibility, "Compound Regisatration" refers to the ability to register Chemical compounds from E-WorkBook to ActivityBase. "Results" refers to the export of tested data from ActivityBase to E-WorkBook The Browser Tabs functionality in the Desktop client require a 32 bit Java JRE (version 6 or 7) to be installed. If working with Office 2007 documents in an environment where Office 2003 is still utilised, the Office 2003 installations must have the Microsoft Office Compatibility Pack for Word, Excel, and PowerPoint 2007 File Formats installed. This is required to ensure that Office 2007 document formats such as.docx and.xlsx can be opened with Office 2003. Prism Support shows the versions of the Prism Viewer or Full version used for IDBS Testing. Where the Full version has not been tested, but the Viewer has, IDBS would expect this to function as expected but cannot guarantee this. Please note no testing is performed with the 'etwork license' of Prism and IDBS cannot guarantee the functionality of this installation type. E-WorkBook Suite 9.3 and below cannot integrate with the Microsoft Certificate Store or PKCS#11 hardware tokens on 64-bit. See KnowledgeBase document KB201302002065 for further details. E-WorkBook Suite 9.4 cannot integrate with PKCS#11 hardware tokens on 64-bit. See KnowledgeBase document KB2013011002280 for further details. S S S S S ID Business Solutions Confidential 7 of 27

10 24 31 7 8 9 10 11 5 6.0 6.1-6.2 7 8 9.2.x C C C C Update 32 otes 9.3.x C C C C Update 32 1 A locally-installed Java runtime environment is required for external 9.4.0 C C C C C Update 45 document editing in E-WorkBook 9.x. The listed Java update refers to 9.4.1-9.4.3 C C C C C C C Update 45 the earliest release tested at IDBS to guarantee support for this feature. 10.0.x C C C C C C /A /A 9.2.x 9.3.x 9.4.0 9.4.1-9.4.3 10.0.x E-WorkBook Web Client Web Browser Firefox Internet Explorer 2 Safari E-WorkBook Web Client Operating System XP Vista 7 8.0 8.1 10 Mac OSX 2 Support for Internet Explorer 10 and 11 is limited to the Desktop version, and not the "Metro style" environment on 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 10.6 10.7 10.8 10.9 10.10 8. E-WorkBook Web Client Applications 3 IDBS External Editor Integration 4, IDBS Spreadsheet Designer, Send To EWB 7 8.0 8.1 10 Mac OSX 32 bit 64 bit 32 bit 64 bit 32 bit 64 bit 32 bit 64 bit 10.6 10.7 10.8 10.9 10.10 10.0.x Java Runtime 1 Supported Update Java 6 Java 7 ote that a locally-installed Java runtime environment is not required for E-WorkBook 10. 3 Web client applications are optional, locally-installed software components that add functionality to the web client. 4 By default, the External Editor Integration application will support the following file extensions:.doc,.docx,.xls,.xlsx,.ppt,.pptx,.prism,.txt 5 External document editing refers to E-WorkBook 9.x only. For E- WorkBook 10.x, please see the IDBS External Editor Integration support for Web Client Applications. Feature E-WorkBook Web Client Feature Support Web Browser Firefox (ESR) Internet Explorer Safari 6 Drag-and-drop functionality requires an HTML5 compatible browser. External document editing 5 Insert files with drag-and-drop 6 IDBS Spreadsheet Web Editor 10 24 31 7 8 9 10 11 5 6.0 6.1-6.2 7 8 General otes For support information about Display Pages and PDF generation using the E-WorkBook Suite Web Client, please see the "E-WorkBook Web Feature Support Matrix" document. PKI authentication and signing is not supported by the E-WorkBook web client. ID Business Solutions Confidential 8 of 27

E-WorkBook Application Server Operating System Server 2003 Server 2008 Server 2012 Solaris 10 Red Hat Linux 4 Red Hat Linux 5 Red Hat Linux 6 Red Hat Linux 7 32Bit 64Bit R1 R2 R1 R2 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 9.2.x /A 9.3.x S /A 9.4.x S /A 10.0.0-10.0.1 /A 10.0.2-10.0.3 /A E-WorkBook Spreadsheet Server Spreadsheet Server Spreadsheet Server Load Balancer Server 2008 Server 2012 Red Hat Linux (all versions) Server 2008 Server 2012 Red Hat Linux (all versions) R1 R2 R1 R2 32Bit 64Bit R1 R2 R1 R2 32Bit 64Bit 10.0.x E-WorkBook Legacy Update Server Operating System Server 2008 Server 2012 Red Hat Linux 5 Red Hat Linux 6 Red Hat Linux 7 R1 R2 R1 R2 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 10.0.x /A S otes The Legacy Update Application Server is required to allow the E-WorkBook 9.x desktop client to be upgraded to E-WorkBook 10.0.0 using Assisted Deployment. ID Business Solutions Confidential 9 of 27

Server Operating System E-WorkBook Oracle Database Server Oracle Server 2003 Server 2008 Server 2012 Solaris 5.9 (Solaris 9) Solaris 5.10 (Solaris 10) Red Hat Linux 4 Red Hat Linux 5 Red Hat Linux 6 Red Hat Linux 7 10.2.x 11.2.x 12.1.x RAC 32Bit 64Bit R1 R2 R1 R2 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 9.2.x /A /A 9.3.x S /A /A 9.4.x S /A /A 10.0.0-10.0.1 /A /A 10.0.2-10.0.3 /A /A otes Oracle 12c is supported in E-WorkBook 10.0.2 and above, and has been tested using version 12.1.0.2 Enterprise only. Please note that only installs are supported; to upgrade from Oracle 11, E-WorkBook must first be upgraded to 10.0.2 before following the "E- WorkBook 10.0.2 - Upgrading or Migrating To Oracle 12c" document to migrate to a new server running Oracle 12. For E-WorkBook 10.0.2 and above, Oracle 12c is only supported on Server 2012 R2 and Red Hat Linux 7; Oracle 11 is only supported on Server 2008 R2 and Red Hat Linux 5 & 6. For E-WorkBook 9.2, 9.3, 9.4 and 10.0 upgrades, Oracle 11.2.0.3 or above must be installed to address Oracle defects corrected by Oracle in this release. IDBS Support recommends installing the latest Oracle patchset. Please note Oracle 11.2.0.4 has only been explicitly tested against E-WorkBook 9.4.1 and above. For E-WorkBook versions up to (and including) 9.2, Oracle 10.2.0.4 (including the latest patchset) or Oracle 10.2.0.5 must be installed due to corrected Oracle defects in the database version. If running Server 2003 32 Bit edition then Oracle patchset 29 or above is recommended due to an additional defect corrected by Oracle in this release. There appears to be an intermittent issue in Oracle 10.2.0.5 that causes some Microsoft Office 2007 documents to fail during the text indexing upgrade step included in a number of E-WorkBook versions. There does not appear to be anything wrong with the documents in question and this does not happen on all systems (it has been seen on 64bit server) and is currently being investigated with Oracle (metalink reference number 3-2824788361). IDBS advises upgrading to the latest patch set for your release. IDBS have observed that performing an out-of-place Oracle upgrade on an E-WorkBook database will encounter Oracle defects related to Oracle text indexing and CDC functionality (CDC in E-WorkBook 10.0.1 and below). Therefore IDBS strongly recommend that a new Oracle instance is created at the required Oracle version and the IDBS export-import procedure is used to migrate an E-WorkBook database. This procedure is described in the E-WorkBook Suite Database Export Import Guide; a version for each E-WorkBook release is available on the Customer Support Portal. For more information see KnowledgeBase article KB201407002474. ID Business Solutions Confidential 10 of 27

InforSense for E-WorkBook Operating System Support Application Server Operating System Server 2003 Server 2008 Server 2012 Red Hat Linux 4 Red Hat Linux 5 Red Hat Linux 6 Solaris 5.10 (Solaris 10) 32Bit 64Bit R1 R2 R1 R2 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 1.0.x S S 1.1.x S 9.3.x 9.4.x 10.0.x 7 8 9 10 10 24 5 (OSX) 6 (OSX) 2003 2007 2010 2013 2016 1.0.x C C C C 1.1.x C C C C 1.0.x 1.1.x IDBS Software E-WorkBook Client 1.6.0_32 InforSense for E-WorkBook Software Compatibility InforSense for E-WorkBook Java Runtime Support 1.7.0_25 Admin Portal Web Browser Internet Exporer Firefox Safari Server 1.6.0_32 1.7.0_25 Oracle MySQL SQL Server MS Office Excel InforSense for E-WorkBook Database Connector Vendor Support DB2 Postgres 10.2.x 11.2.x 12.1.x 5.0.x 2005 RAC 2008 8.2.x 8.2.x 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 1.0.x /A 1.1.x /A otes Please refer to the E-WorkBook Software Support Matrix for client OS, Citrix and language support requirements PKI authentication is not supported when using InforSense for E-WorkBook It is highly recommended that Java Automatic Update is disabled on client machines using the Java Control Panel The IDBS Structure Viewer and Convert Structure Format nodes are only supported on servers running 32 or 64 bit and on the client machine running 32 or 64 bit. IDBSChemRenderer plug-in should not be installed at all on the different configurations. The supported OS version for the IDBS Chemistry is a superset of those supported for InforSense for E-WorkBook. ID Business Solutions Confidential 11 of 27

1.0.0 1.0.1 1.1.0 1.1.1 1.1.2 1.1.3 9.3.0 9.3.1 9.3.2 9.4.0 9.4.1 9.4.1.1 9.4.2-9.4.3 10.0.0-10.0.1 10.0.2-10.0.3 otes E-WorkBook Hub Compatibility Asset Hub The version of the Hub refers to the database version of this release and their compatibility with specific E-WorkBook versions. E-WorkBook PKI authentication is not supported when using the IDBS Hubs. Translational Sciences Hubs Biomolecular Hub 2.0.0 1.0.0 Clinical Data Hub ID Business Solutions Confidential 12 of 27

ActivityBase Suite (this includes all related utilities e.g. Object Manager) Client Operating System MS Office Oracle Client Language Support 7 8.1 10 2003 2007 2010 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 8.0.x 8.1.x - 8.4.x 8.0.x 8.1.x - 8.4.x XP Server 2003 Server 2003 Vista File Server Operating System Server 2008 Server 2008 ActivityBase Suite Application Servers Server 2012 Server 2012 R2 SAMBA Web Server Operating System Server Server Server 2003 2008 R2 2012 R2 32Bit 64Bit 64Bit ActivityBase Suite Oracle Database Server Server Operating System Solaris 5.9 (Solaris 9) Solaris 5.10 (Solaris 10) Red Hat Linux 4 Red Hat Linux 5 Citrix Support Conf. 3 Conf. 4 Conf. 5 Red Hat Linux 6 2013 2016 10.2.x 10.2.x Oracle 11.2.x 12.1.x 11.2.x RAC 12.1.x European O/S & MS Office Japanese O/S & MS Office 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 8.0.x /A S /A 8.1.x - 8.4.x /A S /A 7 8 9 10 11 3.6 31 38 32bit 64bit 8.0.x C C C 8.1.x C C C C 8.3.x C C C 8.4.x C C C C ActivityBase Web Client Web Browser Internet Explorer Firefox (ESR) ActivityBase XE 7.6.x 7.7.x 7.8.x 8.0.x 8.1.x 8.3.x 8.4.x SARview 7.3.0-7.3.2 Chrome 1 7.3.3-7.3.4 5.1.x- 5.3.x XLfit ActivityBase Suite Software Compatibility 5.4.x E-WorkBook 2 ActivityMart Chemistry Registration Results ChemDraw ISIS Draw Symyx Draw Accelrys Draw 3.3.0-3.2.x 3.3.4 9.2.x 9.3.x 9.4.x 10.0.x 9.x 10.0.x 3.3.3 10 11 12 13 14 15 2.1-2.4 2.5 3.2 3.3 4.0 4.1 8.0.0-8.0.4 /A /A S 8.0.5 /A /A S 8.1.x /A /A S 8.3.x S 8.4.x S Chemistry Drawing Packages ID Business Solutions Confidential 13 of 27

otes on-chemistry customers may run ActivityBase on any server hardware supported by the indicated Oracle version. IDBS Chemistry customers must adhere to the Oracle Database Server defintions shown above. The following must be present or checked for each client running ActivityBase: Microsoft Internet Explorer A supported version of Microsoft Office A supported version of the Oracle Client.et 3.0 required for ActivityBase 7.0.x and above.et 3.5 required for ActivityBase 7.4.x and above.et 4.0 required for ActivityBase 8.1.x and above If installing the IDBS Meta Data Administration Console (MAC) it is necessary to install the Oracle provided OLEDB driver on the client workstation. If using the Oracle Data Provider for.et (ODP.et) to connect with IDBS.et applications such as Plate Creator and Reporter with Oracle 10 it is necessary to use those components installed with the provided ODAC1020221.exe Prerequisites file. The ODP.et components supplied with Oracle 10.2.0.4 cause connection problems with these tools. Old style ActivityBase Templates e.g. Standard 4.0, HTS 4.0 and UHTS 4.0 are no longer supported. Support for these ceased on the 2nd of April 2007. Running the ActivityBase system, client - Fileserver - Application Server - Oracle Database Server, is only supported in a LA (Local Area etwork) environment. IDBS do not support the use of the ActivityBase Suite over a WA (Wide Area etwork). It is recommended that the connectivity between the ActivityBase Client and the Oracle Server, Application Server and File Server be at least 100MB/s. Ideally network latency not exceeding 50ms roundtrip time. ActivityBase 8.0.x is compatible with Oracle 10.2.0.5 (or higher Oracle 10gR2) and Oracle 11.2.0.1 (or higher Oracle 11gR2) only. ActivityBase 8.1.x and above supports Oracle 11.2.0.4 only. Server 2012 R2 refers to the Standard edition only. Java is required for editing chemical structures in the ActivityBase 8 web client. ActivityBase 8.0.0 to 8.0.3 supports Java 7 update 40 or below. ActivityBase 8.0.4 to 8.0.5 supports Java 7 update 45. ActivityBase 8.1.x supports Java 7 update 67. ActivityBase 8.3.x/8.4.x supports Java 8 update 45. 1 Support for Chrome on the ActivityBase 8.1.x and above web client is listed as Supported rather than Certified due to the automatic updates of this browser. Testing was carried out using a range of versions between 33 and 43. For further information on Supported and Certified browsers, please refer to the following document: IDBS Web Browser Support Information statement Support for PAPI plug-ins has been desupported from Chrome version 45. See: https://support.google.com/chrome/answer/6213033?hl=en-gb As the chemistry rendering functionality in the web client relies on PAPI, this means editing of chemical structures is no longer possible in Chrome. 2 For E-WorkBook integration, "Compound Registration" refers to registration of chemical compounds from E-WorkBook to ActivityBase. "Results" refers to the export of tested data from ActivityBase to E-WorkBook. Support for Firefox refers to the extended support release (ESR) versions only. ID Business Solutions Confidential 14 of 27

XP Vista Client Operating System 7 8.1 2003 2007 2010 2013 2016 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 32Bit 32Bit 8.0.0-8.0.4 8.0.5 8.1.x 8.3.x 8.4.x 7.6.x 7.7.x 7.8.x 8.0.x 8.1.x 8.3.x 8.4.x otes s prior to XE 7.7 require the Microsoft.et 3.5 Framework. XE 7.7 and above require the Microsoft.et 4 Framework (or higher). 10 ActivityBase XE MS Office Citrix Support Conf. 3 Conf. 4 Conf. 5 Support for 8.1 is limited to XE 7.8 and above when used with a version of ActivityBase that is supported on 8.1, i.e. 8.1 and above. "ActivityBase XE" refers to the XE Designer and Runner applications that run with the ActivityBase Desktop client. For use of XE Runner Standalone, see the table below. ActivityBase Compatibility Running the ActivityBase system, Client - Fileserver - Application Server - Oracle Database Server, is only supported in a LA (Local Area etwork) environment. IDBS do not support the use of the ActivityBase Suite over a WA (Wide Area etwork). It is recommended that the connectivity between the ActivityBase Client and the Oracle Server, Application Server and File Server be at least 100MB/s. Ideally network latency roundtrip time should not exceed 50ms. 7 Operating System 8.1 10 XE Runner Standalone Office 2007 2010 2013 2016 Citrix Support Conf. 3 Conf. 4 Conf. 5 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 32Bit 8.0.x 8.1.x 8.3.x 8.4.x 8.3.x 8.4.x otes XE Runner Standalone requires.et 4. This will be installed by the client install pack if it not already installed. XE Runner Standalone does not require an installation of ActivityBase or an Oracle client. 32 bit is not supported. Multiple versions of XE Standalone are supported on the same computer. The more recent version should be installed last. ActivityBase Compatibility ID Business Solutions Confidential 15 of 27

Client Operating System SARview MS Office Citrix Support Language Support 2003 2007 2010 2013 2016 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 32Bit 32Bit 7.3.0-7.3.2 XP Vista 7 7.3.3 1 8.0.x ActivityBase Compatibility 8.1.x SARview IDBS Software Compatibility 8.3.x 8.1 8.4.x ChemDraw Chemistry Drawing Packages ISIS Draw Symyx Draw Accelrys Draw 10 11 12 13 14 15 2.1-2.4 2.5 3.2 3.3 4.0 4.1 7.3.0-7.3.2 S S S 7.3.3 1 S Conf. 3 Conf. 4 Conf. 5 European O/S & MS Office Japanese O/S & MS Office S S otes 7 support for SARview 7.x is only for version 7.2.1 and above. 8.1 support is limited to SARview 7.3.3. Office 2010 support for SARview 7.x is only for version 7.2.1 and above. Office 2013 support is limited to SARview 7.3.3. SARview 7.x requires Microsoft.et Framework version 3.5 to be installed. Running the SARview client - Oracle Database Server, is only supported in a LA (Local Area etwork) environment. IDBS do not support the use of SARview over a WA (Wide Area etwork). It is recommended that the connectivity between the SARview Client and the Oracle Server be at least 100MB/s. Ideally network latency not exceeding 50ms roundtrip time. 1 SARview 7.3.3 refers to the version provided in two versions of the SARSuite product - 7.3.3 and 7.3.4. ID Business Solutions Confidential 16 of 27

SARgen Client Operating System MS Office Oracle Client Citrix Support Language Support XP Vista 7 8.1 10 2003 2007 2010 2013 2016 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 32Bit 32Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 10.2.x 11.2.x 12.1.x Conf. 3 Conf. 4 Conf. 5 European O/S & MS Office Japanese O/S & MS Office 7.4.0-7.4.1 7.4.1.3 1 7.4.2.2 2-7.4.3 3 IDBS Software Compatibility ActivityBase Compatibility 7.4.x 8.0.x 8.1.x 8.3.x 8.4.x 7.4.0-7.4.1 7.4.1.3 1 7.4.2.2 2-7.4.3 3 otes 1 7.4.1.3 refers to the version of SARgen included in SARSuite 7.3.0 to 7.3.2. 2 7.4.2.2 refers to the version of SARgen included in SARSuite 7.3.3. 3 7.4.3 refers to the version of SARgen included in SARSuite 7.3.4. 7 support for SARgen 7.4.x is only for version 7.4.1 and above. Office 2010 support for SARgen 7.4.x is only for version 7.4.1 and above. The SARgen Client launches in 32 bit mode on 64-bit 7 and requires a 32-bit Oracle Client. Running the SARgen client - Oracle Database Server, is only supported in a LA (Local Area etwork) environment. IDBS do not support the use of SARgen over a WA (Wide Area etwork). It is recommended that the connectivity between the SARgen Client and the Oracle Server be at least 100MB/s. Ideally network latency not exceeding 50ms roundtrip time. ID Business Solutions Confidential 17 of 27

2003 2007 2010 2013 2016 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 32Bit 32Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 7.4.x /A S 7.5.0-7.5.1 /A S 7.5.2-7.5.4 /A S XP 7.4.x Vista Client Operating System 7 8.1 10 MS Office Reporter Reporter IDBS Software Compatibility Oracle 10.2.x 11.2.x 12.1.x ActivityBase E-WorkBook Chemistry Drawing Packages Compatibility Compatibility ChemDraw ISIS Draw Symyx Draw Accelrys Draw 8.0.x 8.1.x - 8.4.x 9.2.x 9.3.x 9.4.x 10.x 10 11 12 13 14 15 2.1-2.4 2.5 3.2 3.3 4.0 4.1 7.4.x S S S 7.5.0-7.5.1 S S S 7.5.2-7.5.4 S otes 7 and Office 2010 support for Reporter 7.4.x is only for version 7.4.4 and above. 8.1 and Office 2013 support is for Reporter 7.5.2 only. The Reporter Client launches in 32 bit mode on 64-bit 7 and requires a 32-bit Oracle Client. Conf. 3 Citrix Support Running the Reporter client - Oracle Database Server, is only supported in a LA (Local Area etwork) environment. IDBS do not support the use of Reporter over a WA (Wide Area etwork). It is recommended that the connectivity between the Reporter Client and the Oracle Server be at least 100MB/s. Ideally network latency not exceeding 50ms roundtrip time. Platform Support for Reagent Finder for E-WorkBook is defined as the supported Reporter releases for a particular E-WorkBook version. Reagent Finder is not supported in E-WorkBook 10. Conf. 4 Conf. 5 Language Support European O/S & MS Office Japanese O/S & MS Office ID Business Solutions Confidential 18 of 27

otes 2003 2007 2010 2013 European Japanese ActivityBase Compatibility 2016 XP Vista 7 8.1 10 Conf. 3 Conf. 4 Conf. 5 O/S & MS O/S & MS Office Office 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 32Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 8.0.x 8.1.x 8.3.x 8.4.x 5.2.x S 5.3.x S 5.4.x S XLfit is only supported on Microsoft operating systems as indicated above. XLfit does not support any Apple Mac operating systems. 7 64Bit support for XLfit 5.2.x is only for version 5.2.1 and above. For further details about Office support with Vista please use the following Microsoft link: http://support.microsoft.com/kb/932087 Client Operating System XLfit MS Office Citrix Support Language Support ID Business Solutions Confidential 19 of 27

Server 2003 Server 2008 Solaris 5.9 (Solaris 9) Server Operating System Solaris 5.10 (Solaris 10) Red Hat Linux 3 ChemXtra Red Hat Linux 4 Red Hat Linux 5 10.2.x Oracle 11.1.x 11.2.x 12.1.x RAC Support 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 7.x S /A 8.0.x /A 8.2.x S /A otes On Solaris systems a set of patches will be required as part of an Oracle Installation. Further software products, patches and packages may also be necessary for the installation of Oracle. The two required patches for IDBS Chemistry are: 111712 This is the C++ standard library patch 111722 This is the maths library libm patch Please install the latest updated patches for Solaris. To check if a given patch is present (e.g., 109147) enter (as root): 1. Type the following: patchadd -p grep 109147 will show all versions of the patch you have, and you need to have at least the required dash-revision or higher. Patch: 109147-24 Obsoletes: Requires: Incompatibles: Packages: Only SPARC versions of Solaris are supported for IDBS Chemistry. otes Client Operating System Language Support ChemIQ Chemistry Drawing Packages XP Vista 7 8 European O/S Japanese O/S ChemDraw ISIS Draw 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit & MS Office & MS Office 10 11 12 13 2.1-2.4 2.5 7.x S S S S 8.0.x S S 8.2.x S S IDBS only support ISIS advanced stereochemical representations available in ISIS Draw 2.5 and above, in Chemistry Technology version 8.x and above Symyx Draw 3.2 3.3 S ID Business Solutions Confidential 20 of 27

2003 Server 2008 Server Server Operating System Solaris 9 & 10 Red Hat Linux 4 Red Hat Linux 5 Other UIX Platforms 10.2.x ActivityMart Oracle 11.2.x 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 8.0.0-8.0.4 8.0.5 8.1.x 8.3.x 8.4.x 9.2.x 9.3.x 9.4.x 10.0.x 12.1.x ActivityBase Compatibility E-WorkBook Compatibility Language Support European O/S Japanese O/S 3.1.x S S /A 3.2.x S S /A 3.3.0-3.3.1 S S /A 3.3.2-3.3.3 S S /A 3.3.4 S S /A 1 ActivityMart Admin Console Application Server Web Browser 2003 Server 2008 Server Firefox Internet Explorer 32Bit 64Bit 32Bit 64Bit 3.6 39 7 8 9 10 11 3.3.x C S S C C S C otes 1 E-Workbook 9.4.x support is limited to ActivityMart 3.3.4 and E-WorkBook 9.4.2. Please note that catalog inheritence and the Asset Hub are not supported. E-WorkBook 9.2.x support for ActivityMart 3.3.2 and above is limited to versions 9.2.0 to 9.2.3. For later versions of E-WorkBook 9.2.x, ActivityMart must be patched to version 3.3.3.1. ActivityMart 3.2, a RedHat Linux issue requires the Oracle server to be patched to version 4.3 of the RedHat operating system. ActivityMart 3.1 must be run with an Oracle 10.2.0.4 version of Oracle due to corrected Oracle defects in this version. Oracle 8 bit characterset such as WE8ISO8859P1 is required. For the Japanese platform a multibyte characterset such as JA16SJIS is required. Prior to ActivityMart 3.2, an FTP service must be available to transfer files between the ActivityBase Oracle server and the ActivityMart Oracle server(s). Oracle Java options must be installed. ID Business Solutions Confidential 21 of 27

XP PredictionBase Client Operating System MS Office Oracle Vista 7 Oracle Server Operating System Citrix Support Solaris 5.8 Red Hat Red Hat 8 10.2.x 11.2.x 2003 2007 2010 2013 Server 2003 (Solaris 8) Linux 3 Linux 5 Conf. 3 Conf. 4 Conf. 5 ActivityBase Compatibility 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 7.x 8.x 7.0.x otes Compatibility with ActivityBase is limited to basic access to key data required to support PredictionBase analysis. ID Business Solutions Confidential 22 of 27

Client Operating System InforSense Suite Application Server Operating System Citrix Support Language Support 2000 XP Vista 7 8-10 Mac OS X Tiger Mac OS X Leopard 2000 Server 2003 Server 2008 Red Hat Linux 5 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit SuSe Linux 9 Mac OS X Tiger Mac OS X Leopard Solaris 5.8 (Solaris 8) Conf. 2 Conf. 3 European O/S Japanese O/S 4.1.x S S S S S S S 5.0.x S S S S S S S 5.1.x S S S S S S S S 2003 2007 2010 2013 2016 6 7 8 2.0.x 3.0.x 3.5.x 6 7 8 2.0.x 3.0.x 3.5.x 32Bit 32Bit 32Bit 32Bit 32Bit 4.1.x C C C C S C S S 5.0.0 C C S C S C S S 5.0.1 C S C S C S S C S 5.1.x C C C S C C S S C User Portal Web Browser Admin Portal Web Browser Internet Exporer Fire Fox Internet Exporer Fire Fox InforSense Suite Java Runtime Requirements Client InforSense Suite Application Server 1.5.0_09-15 1.6.0_18 1.7.0.x 1.5.0_09 1.5.0_15 1.6.0_17 1.7.0.x MS Office 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 4.1.x S S 5.0.x 5.1.x 9.2.x 10.1.x 10.2.x 11.2.x RAC 4.1.x 5.0.x 9.0.x 8.2.x 8.2.x 2003 Support 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 4.1.x S S S S S S S S S S 5.0.x S S S S S S S S S S 5.1.x S S S S S S S S S S S otes InforSense Suite Database Vendor Support Oracle MySQL SQL Server DB2 Postgres Access (ODBC) Exporting to Microsoft Powerpoint from the workflow requires the InforSense server installation to be in under a OS environment with Office 2003 preinstalled InforSense client OL support for 7 is from version 5.1.2.2 onwards Omics Workbench is OT supported on Mac based server and client InforSense installations ID Business Solutions Confidential 23 of 27

ClinicalSense Application Server Application Server Operating System Server 2003 Server 2008 Red Hat Linux 5 SuSe Linux 9 Mac OS X Leopard Solaris 5.8 (Solaris 8) 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 4.1.x S S S S 5.0.x S S S S 5.1.x S S ClinicalSense Oracle Database Server 10.2.x Oracle 11.2.x 32Bit 64Bit 32Bit 64Bit 4.1.x S 5.0.x S 5.1.x S S RAC Support ClinicalSense Web Client User Portal Web Browser Internet Exporer Firefox otes 6.0.x 7.0.x 8.0.x 2.0.x 3.0.x 3.5.x 4.1.x C C 5.0.x C S C 5.1.x C C C Oracle 11.2.x support for ClinicalSense version 5.1.x excludes the support of 5.1.0.0 and only applies to subsequent versions ID Business Solutions Confidential 24 of 27

ChemSense Application Server Application Server Operating System Server 2003 Server 2008 Red Hat Linux 5 SuSe Linux 9 Mac OS X Leopard Solaris 5.8 (Solaris 8) 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 5.1.x S S ChemSense Workflow Builder Client Operating System 2000 XP Vista 7 8 Mac OS X Tiger Mac OS X Leopard 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 5.1.x S S S ChemSense Web Client User Portal Web Browser Internet Exporer Firefox otes 6.0.x 7.0.x 8.0.x 2.0.x 3.5.x 3.6.x 5.1.x C C C C Minimum JVM is 1.6.0_18 for the client and 1.6.0_17 for the server Accelrys Jdraw: The supported version for the accelrysjdraw plugin is 1.1 SP2 (licensed with AccelrysDraw 4.0) ChemAxon: The supported version is 5.4.0.1 the way they supply this in so many resource files which change from release to release means that IDBS cannot easily support even a different minor release. They still make available all old versions such as this, easily available from their download site at www.chemaxon.com IDBSChemRenderer: The IDBS plugin is only supported on servers running (32 of 64 bit) and on client machines running 32-bit windows (or using a 32-bit JVM and 32-bit browser). It should not be installed at all on different configurations. The supported OS versions for IDBS chemistry are a superset of those supported for InforSense. ote that as it incorporates version 8.2 of chemistry, the output of the IDBS nodes cannot be used for querying ChemXtra versions older than 8.0 unless Molfiles/Rxnfiles/SMILES strings are used to transmit the query structures. The Chemical Drawing tool configurations are the same as for ChemTech 8.2, i.e.: ISIS/Draw 2.5, SymyxDraw 3.3, and ChemDraw 10-12. JRE versions 1.6.0_24 and later do not confer full privileges on applet code that is not loaded straight away, so you cannot copy to the clipboard properly from the AccelrysJDraw popup applet in these versions. Downgrade JRE to circumvent the problem, or adjust the security profile in your Java Web Start config directories. This does not affect the AccelrysJDraw sketcher applet, or the other technologies. Certain older minor versions of FireFox 3.6 do not work correctly with applets at all any applet relaunched or reloaded fails and gets displayed as a black square on the screen (affects ChemAxon, IDBS and Accelrys applets). The solution is to upgrade to a later minor release. Inchi file format support depends on ChemAxon code that uses presupplied native libraries: these are currently available for Linux 32 and 64 bit, 32 and 64-bit, and Mac OSX ID Business Solutions Confidential 25 of 27

Biomolecular Hub for InforSense Application Server Operating System InforSense Server 2003 Server 2008 Red Hat Linux 5 SuSe Linux 9 Mac OS X Leopard Solaris 5.8 (Solaris 8) 5.0.x 5.1.x 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 1.0 S S 1.1 S S otes Biomolecular Hub Database Server Oracle 10.2.x 11.2.x 32Bit 64Bit 32Bit 64Bit RAC Support 1.0 S 1.1 S On this page, Biomolecular Hub refers to version 1 for us with InforSense 5.1. For support for Biomolecular Hub for E-WorkBook, please see page 11. Support for Oracle 11.2 is for both Enterprise and Standard versions ID Business Solutions Confidential 26 of 27

2003 2007 2010 2013 2016 2011 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 32Bit 64Bit 10.6 10.7 10.8 10.9 10.10 32Bit 32Bit 32Bit 64Bit 4.0.x S S S S S 4.1.x S S S S S 5.0.x S S S S S 5.1.x - 5.3.x S S S S S Chrome Internet Explorer Firefox Safari 33 8 9 10 11 33 8 Client Operating System XP Vista 7 8 10 OS X Quantrix Qloud Web Browser Quantrix MS Office 32/64 Bit 32/64 Bit Mac OS X Conf. 3 Citrix Support Conf. 4 Conf. 5 Language Support European O/S & MS Office Japanese O/S & MS Office otes Support for OS X is for Intel-based Macs running Java. For versions of Quantrix up to 5.0, Java 6 is required; for Quantrix 5.1 and above, Java 7 is required. Quantrix s 1.x, 2.x and 3.x have reached end of life and are not longer actively developed or supported. We recommend 32bit version to have 800MB of RAM available on the system. ID Business Solutions Confidential 27 of 27