COURSE GUIDE DEGREE DEGREE: MEDICINE ACADEMIC YEAR 2016/2017 COURSE: THIRD Course Title MICROBIOLOGY AND IMMUNOLOGY ECTS Type Period Calendar Pre-requisites Total Basic Obligatory Optional 1 er C 2ºC Weeks 7 X X 15 NONE Course Language Spanish Valenciano English X French Department PHARMACY Specific Area of knowledge IMMUNOLOGY, MICROBIOLOGY AND PARASITOLOGY Corse Coordinator and other Professors Dra Verónica Veses Name Dr Chirag Sheth Office / Faculty Email Student appointment schedule CONSULT THE DIRECTORY PAGES ONLINE veronica.veses@uchceu.es chirag.sheth@uchceu.es The timetable for requesting an appointment is published on the intranet. Introduction to the Course The Microbiology part of the course empowers the student with the scientific knowledge and practical skills required in the medical practice and in the control of infections and infectious diseases. It is a fundamentally etiological discipline in which microorganisms as biological agents are discussed solely in connection with their pathogenic status in humans, and based on medical conditions caused (etiology, epidemiology, pathogenesis, laboratory diagnosis, and antimicrobial therapy). The Immunology program has been developed with the aim of studying the functional bases of the immune system, to understand the mechanisms of recognition, activation, maturation and effector role of this system in the maintenance of health and disease processes. Medicine/Microbiology and Immunology/2016-2017 1
Pre-requisites Not essential, however, recommend previous working knowledge of: Biology Biochemistry Praxis and Research Methodology II Genetics Course Objetives The course objectives are listed below. By the end of this course, students will be able to: 1. Demonstrate knowledge of structure and biological properties of microorganisms to interpret the pathogenesis of infection and diagnostic, therapeutic and preventive implications. 2. Acquire the knowledge required to understand the basis of the identification and classification of microorganisms. 3. Describe the main biological characteristics of various microorganisms (bacteria, viruses, fungi, protozoa, and helminths), their pathogenesis and other medical implications. 4. Describe the antimicrobial activity against different groups of pathogens and know the genetic and biochemical mechanisms involved in resistance and their clinical implications. 5. Understanding the mechanisms of action of the immune system against pathogens. Understand their clinical application, vaccines and monoclonal antibodies. Additionally, via the practical series, the students will be able to: 1. Manage materials and basic laboratory techniques. 2. Understand and use macroscopic, microscopic and imaging methods for investigating the morphology and structure of microorganisms General and Specific Skills Offered by the Course General Skills General Skill 1 Knowledge Acquisition Building on the foundations laid during their secondary education and with the support of advanced textbooks, the students will be able to demonstrate a levels of knowledge and understanding equivalent to those at the forefront of their field of study. General Skill 2 Application of Knowledge Students will be able to apply their knowledge to their work or vocation in a professional manner and possess the skills typically demonstrated through devising and sustaining arguments and solving problems within epidemiology and public health. General Skill 3 Collect and Interpret and Analyse Relevant Data Students will gain the ability to gather and interpret relevant data to inform judgments that include reflection on social scientific and ethical issues. General Skill 4 Communication Students will gain the opportunity to improve their communication skills via dissemination of information, ideas, problems and solutions to both specialist and non-specialist audiences. General Skill 5 Independent Learning Students will be required to develop learning skills necessary to undertake in depth, detailed studies with a high degree of autonomy Specific Skills SS1 Microbiology and Immunology Knowledge To learn the fundamentals of microbiology and immunology SS2 Microbiology and Immunology Techniques To learn the main techniques of microbiological and immunological diagnosis and interpretation of results SS3 Clinical Microbiology and Immunology Medicine/Microbiology and Immunology/2016-2017 2
General and Specific Skills Offered by the Course Learning how to obtain and process a biological sample for study using the different diagnostic procedures. Learning the major human infectious agents and their mechanisms of action. Transversal Skills TS1 Learn about the application of biological research in the health sciences TS2 Critical reasoning and reading. Build knowledge about key types and sources of scientific information and articles, as well as developing the skills to be able to critically evaluate their usefulness and worth. TS3 Risk assessment. Develop the ability to identify and understand the risks associated with multi-step integrated processes. The ability to interpret and identify basic hazards and hazard signs. TS4 Problem solving and project design. Be able to discuss and critically develop protocols and strategies for solving complex problems using an array of sources of information, and to present them to their peers in a variety of formats in a coherent and knowledgeable fashion. TS5 Oral presentation. Develop skills in oral presentation of highly detailed material to a variety of audiences, including health professionals, and fellow scientists Course Contents IMMUNOLOGY - Basics - Immune system cells - Recognition of antigens - Immune response - Immune system in disease - Applications MICROBIOLOGY - Basic principles of medical microbiology - General principles of laboratory diagnosis - Bacteriology - Virology - Mycology - Parasitology Course Structure and Design Lectures Training activity oriented mainly to knowledge acquisition (General Skill 1) and presentation of subject theory material. Prioritizes the transmission of knowledge by the lecturers, this requires the student to carry out prior preparation and further study to supplement the information supplied by the lecturers. Practicals Training activity oriented mainly to develop the skill of knowledge transfer or application and is presented in the form of practical activities. These studies will provide a strong grounding in microbiological and immunological research and allow the students to develop a ground-up approach to the importance of microbiology and immunology knowledge in medicine. Seminars The course material is reinforced and enriched by a series of seminars* that students are required to attend. The seminars will seek to build and develop the concepts raised in the classroom, in an open and collaborative environment. The seminar topics have been carefully selected to combine and complement the course material. Students will acquire specific skills related to scientific research, and also develop valuable techniques in teamwork and individual presentations. *Note: The content and order of the seminars is subject to change based on the requirements of the group and availability of necessary material Medicine/Microbiology and Immunology/2016-2017 3
Estimation of Student Workload MICROBIOLOGY AND IMMUNOLOGY Credits ECTS: 7 Breakdown of Student Work Hours Formative Activity Contact Hours (A) Independent Study (B) Total Work Hours (C) C = A + B TAUGHT CLASSES Presentation 1 0 1 Theory Classes 62 31 93 Debates Feedback and Review of Assignments Others PRACTICAL CLASSES Problem Solving Debates Feedback and Review of Assignaments Simulaciones Laboratory 18 4.5 22.5 Practicals in the Computer Lab Visits Presentation and discussion about coursework assignments Other SEMINAR CLASSES Problem Solving 6 1 7 Debates 6 1 7 Feedback and Review of Assignaments 6 1 7 WORKSHOPS Feedback and Review of Assignaments 5 1 6 Oral Presentations 2 0.5 2.5 COURSEWORK Preparation time required EXAMS AND ASSESSMENTS Exam preparation time 26 26 Exams and Tests 3 3 Others TOTAL 109 66 175 RELATIONSHIP BETWEEN WORK HOURS AND ECTS CREDITS (The result of dividing the number of work hours by the number of ECTS credits assigned for the course should equal 25 hours as this is the value of 1 ECTS credit at the Universidad CEU Cardenal Herrera) 175/25 = 7 ECTS credits Assessment Criteria Student evaluation will be carried out by a system of continuous assessment based on tests, exams and practical assignments. The purpose of continuous assessment is to encourage and motivate the progress of pupils throughout the course. It is calculated as a combination of the degree of student involvement, the acquisition of knowledge and the completion of the assignments set during the practical sessions. Questions may be drawn from, and not limited to the published class slides, reading material and other sources of external material as deemed suitable by the professor. The course is evaluated by combining a final exam (theoretical, 50%) with a continuous evaluation system (practical-theoretical, 50%), divided as follows: Medicine/Microbiology and Immunology/2016-2017 4
Assessment Criteria A. Theoretical Examination: 50% of the final subject grade. Students must score a minimum of 5 overall in order for the grades from the continuous evaluation system to be taken into account. The test will include approximately 15% integrated medicine type exam questions. B. Continuous Assessment: 20% - Active participation and attendance to classes 30% - Mid-Term Exams To pass the course, students should achieve a minimum of 5 by adding the scores of each of the assessment types (A and B). In the event that students do not achieve the required pass mark for this subject in the first examination session, the University regulations state that, to give every student an opportunity to gain the maximum score, the marks for continuous evaluation part of the course will NOT be applied to the re-sit exam score. Attendance to the practical and seminar sessions is compulsory. Any student missing 3 or more practicals and / or seminars will automatically fail the course. If a student wishes to change practical groups, they must inform the professor BEFORE carrying out the change. The only type of change authorised is a one-for-one exchange. Students who enroll for this subject for the second time will NOT be evaluated via the continuous assessment system unless they request this of the Professor IN WRITING before the start of the course. In this case, the final course mark will be based purely on the final exam. Course Program IMMUNOLOGY Topic 1: Base of the immune response. Cytokines. Inflammation Topic 2: Cell Marker. Cells and lymphoid tissues. Mucous membranes and skin Topic 3: Antibodies Topic 4: TCR and MHC molecules Topic 5: Regulation of cellular and humoral immune response Topic 6: Immune response to infections and cancer Topic 7: Allergies and hypersensitivity Topic 8: disorders of the immune system and immunogenetics Topic 9: Alloimmunity and pregnancy Topic 10: Biotechnology. Vaccines. MICROBIOLOGY PART 1.: INTRODUCTION Topic 1. Introduction to Medical Microbiology. The Microbial world. PART 2. GENERAL BACTERIOLOGY Topic 2. Bacterial classification and nomenclature. Topic 3. Bacterial morphology and structure. Bacterial staining procedures. Topic 4. Nutrition and metabolism. Enzymes. Fermentation and respiration. Topic 5. Microbial genetics Topic 6. Microbial growth Topic 7. Microbial growth control. Sterilization and disinfection. Medicine/Microbiology and Immunology/2016-2017 5
Course Program Topic 8. Antimicrobial agents. Topic 9. Host-pathogen relationships in bacterial infections. Infection and disease. Pathogenicity and virulence. Koch s Postulates. Topic 10. Diagnostic microbiology. PART 3. SYSTEMATIC BACTERIOLOGY Topic 11. Staphylococci Topic 12. Streptococci Topic 13. Enterococci and other gram positive cocci Topic 14. Bacillus Topic 15. Listeria and Erysipelothrix Topic 16. Corynebacterium and other gram positive bacilli Topic 17. Nocardia and related bacteria Topic 18. Mycobacterium Topic 19. Neisseria and related genera Topic 20. Enterobacteriaceae Topic 21. Vibrio and Aeromonas Topic 22. Campylobacter and Helicobacter Topic 23. Pseudomonas Topic 24. Haemophilus and related bacteria Topic 25. Bordetella Topic 26. Brucella and Francisella Topic 27. Legionella Topic 28. Other gram negative bacteria Topic 29. Anaerobic bacteria Topic 30. Treponema, Borrelia, and Leptospira Topic 31. Mycoplasma and Ureaplasma Topic 32. Rickettsia and Orientia Topic 33. Ehrlichia, Anaplasma and Coxiella Topic 34. Chlamydiaceae PART 4. VIROLOGY Topic 35. Viruses and other subcellular agents. Viral transmission Topic 36. Papilomavirus and Poliomavirus Topic 37. Adenovirus, Herpesvirus and Poxvirus Topic 38. Parvovirus, Picornavirus and Coronavirus Topic 39. Orthomyxovirus, Paramyxovirus and Rhabdovirus. Topic 40. Reovirus, Togavirus and Flavivirus. Topic 41. Bunyaviridae, Arenavirus and Retrovirus Topic 42. Hepatitis virus and Human prion infections. PART 5. MYCOLOGY. Topic 43. General characteristics of fungi Topic 44. Fungi producing superficial mycoses, subcutaneous and systemic infections Topic 45. Opportunistic fungal pathogens Topic 46. Mycotoxins and mycotoxicosis PART 6. PARASITOLOGY. Topic 47. General characteristics of human parasites Topic 48. Protozoa Topic 49. Helminths Detailed Course Contents IMMUNOLOGY: Medicine/Microbiology and Immunology/2016-2017 6
Detailed Course Contents - Lectures. Taught during the first semester - Practicals: 2 laboratory based sessions - Seminars: According to the schedule published on the intranet MICROBIOLOGY - Lectures. Taught during the first semester - Practicals: 3 laboratory based sessions - Seminars: According to the schedule published on the intranet Basic Bibliography KUBY IMMUNOLOGY 7TH EDITION, Judith A Owen; Jenni Punt; Sharon A Stranford; Patricia P Jones; Janis Kuby, Editorial: New York : W.H. Freeman and Company, [2013] MEDICAL MICROBIOLOGY 7TH EDITION, Patrick R Murray; Ken S Rosenthal; Michael A Pfaller, Editorial: Philadelphia : Mosby/Elsevier, [2013] Additional Reading The lecturers will regularly suggest additional reading material throughout the academic year. Students will be examined on knowledge and information gained from these sources. Students are actively encouraged to read widely around the subject in their private study time as exam questions may be derived from material not directly provided to the students in lectures. Other Support Materials The lecturers will provide students with PowerPoint slides used in the lectures. Additionally, the library has been requested to supply the basic bibliography above. Recommendations to Students Taking This Course Use the teaching notes in combination with personal literature searches and study to help you master the subject. Students are encouraged to attend the lectures and dedicate personal time to studying the course material in order to have an integrated view of research in this field. It is strongly recommended that the student carries out the assignments set for continuous assessment and performs all the tasks listed in the schedule in the recommended timeframe. Students are also advised to read the texts (articles and book references) recommended by the lecturers during lectures. Links to Ongoing Research The research experience of the lecturers responsible for the course will contribute to a better understanding and more practical view of the matter. Links to the Medical Profession In this course students will receive information on the basic concepts of Microbiology, with special focus on the role of microorganisms in infectious disease and their impact on human health. An in depth description of the human immune system will also be covered in this course. This is an essential subject for the future graduate in Medicine, independently of the specialization route chosen. Medicine/Microbiology and Immunology/2016-2017 7