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ITA EP N TRADUZIONE EP TITOLO PRINCIPIO ATTIVO MARCHIO DEPOSITO SCADENZA EP633784 EP652766 EP656775 RM2002B047565 MI2008B025368 RM1998B048516 EP656780 MI1997B025294 EP658118 MI2002B023364 EP591710 RM1996B048988 EP593897 EP668851 EP670719 EP602454 EP674621 EP680320 RM1995B052453 MI1997B026105 RM2000B049688 MI1996B025352 TO2003B069304 UD1999B083414 HEPATITIS VACCINS CONTAINING 3 0 DEACYLATED MONOPHOSPHORYL LIPID A HUMAN GROWTH HORMONE AQUEOUS FORMULATION SUSTAINED RELEASE TABLETS CONTAINING BUPROPION DRUGS CONTAINING DIPHOSPHONIC ACIDS AND SALTS THEREOF VACCINES AGAINST GROUP C NEISSERIA MENINGITIDIS INJECTION SOLUTIONS CONTAINING MESNA STABILIZED SOLUTIONS OF ALKYLPHOSPHOCHOLINE IN GLYCEROLALKYLETHER A NOVEL ARYLPROPIONIC DERIVATIVE, A PROCESS FOR THE PREPARATION AND THE USETHEREOF AS AN ANALGESIC AGENT COMBINATION OF ATOVAQUONE WITH PROGUANIL FOR THE TREATMENT OF PROTOZOAL INFECTIONS N OXYCARBONYL SUBSTITUTED 5' DEOXY 5 FLUOROCYTIDINES ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5 HT1 LIKE AGONISTS STABLE ORAL CI 981 FORMULATION AND PROCESS OF PREPARING SAME VACCINO ANTIEPATITE B (RDNA) ADIUVATO ADSORBITO ORMONE DELLA CRESCITA UMANA RICOMBINANTE BUPROPIONE CLORIDRATO FENDRIX 24/03/1993 24/03/2013 NUTROPIN 29/07/1993 29/07/2013 WELLBUTRIN ELONTRIL 13/08/1993 13/08/2013 ACIDO IBANDRONICO BONDRONAT 19/08/1993 19/08/2013 VACCINO MENINGOCOCCICO GRUPPO C TT CONIUGATO MESNA NEISVAC C 30/08/1993 30/08/2013 MESNEX UROMITEXAN 13/09/1993 13/09/2013 MILTEFOSINE MILTEX 13/09/1993 13/09/2013 DEXKETOPROFENE TROMETAMOLO ATOVAQUONE E PROGUANILE DESKETO ENANTYUM KETESSE MALARONE MALARONE BAMBINI 09/11/1993 09/11/2013 25/11/1993 25/11/2013 CAPECITABINA XELODA 01/12/1993 01/12/2013 FROVATRIPTAN AURADOL RILAMIG 16/12/1993 16/12/2013 ATORVASTATINA TOTALIP 20/12/1993 20/12/2013 Elenco aggiornato al 27.11.2013 Pagina 1 di 15

IT1274249 EP678122 MI1999B027762 RECOMBINANT ANTI VLA4 ANTIBODY MOLECULES EP693134 MI1997B027196 ARYLALKANOIC ACID RESOLUTION EP711154 MI2003B023458 STABILIZED PHARMACEUTICAL COMPOSITION CONTAINING BUPROPION EP721335 MI2005B031917 MYCOPHENOLATE MOFETIL HIGH DOSE ORAL SUSPENSIONS EP721331 TO2002B067894 PROCESS I NATALIZUMAB TYSABRI 07/01/1994 07/01/2014 DEXKETOPROFENE TROMETAMOLO BUPROPIONE CLORIDRATO DESKETO ENANTYUM KETESSE WELLBUTRIN ELONTRIL 03/03/1994 03/03/2014 29/07/1994 29/07/2014 MICOFENOLATO MOFETILE CELLCEPT 27/09/1994 27/09/2014 SYMBICORT SINESTIC 29/09/1994 29/09/2014 EP721332 TO2002B071434 PROCESS II SYMBICORT 29/09/1994 29/09/2014 EP722439 MI2002B030449 HIV PROTEASE INHIBITORS NELFINAVIR VIRACEPT 07/10/1994 07/10/2014 EP723444 TO1997B069936 LEVOBUPIVACAINE USEFUL FOR MANAGING CHRONIC PAIN LEVOBUPIVACAINE CHIROCAINE 13/10/1994 13/10/2014 EP723445 TO1997B068421 ANALGESIC AGENT AND ITS USE LEVOBUPIVACAINE CHIROCAINE 13/10/1994 13/10/2014 EP727210 TO2002B068244 ANALGESIC AGENT AND ITS USE LEVOBUPIVACAINE CHIROCAINE 13/10/1994 13/10/2014 EP730470 MI2002B026144 IMPROVED INTERFERON POLYMER PEGINTERFERONE ALFA CONJUGATES 2B PEGINTRON 10/11/1994 10/11/2014 EP741565 MI2000B023698 PROCESS FOR PRODUCING S(+) IBUPROFEN PARTICLES DEXIBUPROFENE SERACTIL CP 26/01/1995 26/01/2015 EP742715 EP814787 EP754048 EP679718 MI1999B023031 TO2003B067243 MI2001B024703 MI2001B026410 ORAL LIQUID COMPOSITIONS CONTAINING PAROXETINE RESINATE FORMULAZIONI FARMACEUTICHE A BASE DI CARBOSSIMETILCISTEINA SALE DI LISINA OIL IN WATER EMULSIONS CONTAINING PROPOFOL AND DISODIUM EDETATE TREATMENT OF PARTIAL GROWTH HORMONE INSENSITIVITY SYNDROME PROCESS FOR PRODUCING ALPHA INTERFERON PAROXETINA S CARBOSSIMETILCISTEINA SALE DI LISINA MONOIDRATO EUTIMIL SEROXAT SEREUPIN 30/01/1995 30/01/2015 FLUIFORT SCIROPPO 08/02/1995 08/02/2015 PROPOFOL DIPRIVAN 17/03/1995 17/03/2015 IGF I INCRELEX 24/03/1995 24/03/2015 INTERFERONE ALFA 2A RICOMBINANTE ROFERON A 29/03/1995 29/03/2015 Elenco aggiornato al 27.11.2013 Pagina 2 di 15

EP757684 EP773940 EP783525 EP779805 EP777495 Elenco dei brevetti non coperti da certificato complementare di protezione RM1999B050612 TO2011B067180 MI2006B037253 MI2002B020731 RM2000B050463 PROCESS FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES HUMANIZED ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS SUSTAINED RELEASE OF PEPTIDES FROM PHARMACEUTICAL COMPOSITIONS STABLE, AQUEOUS ALFA INTERFERON SOLUTION FORMULATIONS EP810877 RM2002B048137 HEPATITIS B VACCINE EP736303 MI1999B027582 INTERFERON SOLUTION EP1394179 EP843672 EP843673 EP623629 EP869796 EP882024 MI2006B032442 TO2003B067575 TO2002B067246 TO1996B070023 MI2003B027399 MI2002B021132 PROCESS FOR PRODUCING ERYTHROPOIETIN FREE FROM ANIMAL PROTEINS ONE POT SYNTHESIS OF 2 OXAZOLIDINONE DERIVATIVES ONE POT SYNTHESIS OF 2 OXAZOLIDINONE DERIVATIVES PURIFIED HEPARIN FRACTIONS, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME A GLIBENCLAMIDE METFORMIN COMBINATION FOR THE TREATMENT OF DIABETES MELLITUS OF RETROVIRAL PROTEASE INHIBITING COMPOUNDS LAMIVUDINA ZEFFIX 21/04/1995 21/04/2015 ESOMEPRAZOLE MG NEXIUM COMPRESSE 03/07/1995 03/07/2015 PALIVIZUMAB SYNAGIS 09/08/1995 09/08/2015 LANREOTIDE IPSTYL 31/08/1995 31/08/2015 INTERFERONE ALFA 2B RICOMBINANTE INTERFERONE ALFA 2A RICOMBINANTE METOSSIPOLIETILENGLIC OLE EPOETINA BETA INTRON A 10/10/1995 10/10/2015 FENDRIX 15/02/1996 15/02/2016 ROFERON A 30/03/1996 30/03/2016 MIRCERA 10/05/1996 10/05/2016 ZOLMITRIPTAN ZOMIG 02/08/1996 02/08/2016 ZOLMITRIPTAN ZOMIG 02/08/1996 02/08/2016 NADROPARINA CALCICA GLIBENCLAMIDE; METFORMINA FRAXIPARINA FRAXODI SELEPARINA SELEDIE 21/08/1996 21/08/2016 GLICONORM 07/11/1996 07/11/2016 LOPINAVIR/RITONAVIR KALETRA 06/12/1996 06/12/2016 Elenco aggiornato al 27.11.2013 Pagina 3 di 15

EP814797 EP890359 EP936913 Elenco dei brevetti non coperti da certificato complementare di protezione MI2003B023684 MI2002B027236 MI2012B031906 PARENTERAL PHARMACEUTICAL COMPOSITIONS CONTAINING ALKYLAMMONIUM SALTS OF 2 ARYLP TABLETS CONTAINING BETA LACTAM ANTIBIOTIC AND PROCESS FOR PRODUCING THE SAME ORAL PHARMACEUTICAL PREPARATION CONTAINING IBANDRONAT EP809996 MI2003B025999 INTERFERON CONJUGATES EP907364 EP912518 EP948358 EP1007017 EP1009394 EP1019033 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS TO2002B071892 COMPRISING A DIBENZOTHIAZEPINE DER SUBSTITUTED PYRIDINES AS RM2003B052451 SELECTIVE CYCLOOXYGENASE 2 INHIBITORS STABLE LIQUID INTERFERON MI2012B020624 FORMULATIONS NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF 0.28 TO 0.38 TO2011B067562 G/ML, A PROCESS FOR PREPARING THE FORMULATION AND THE USE THEREOF TO2004B068272 TO2008B069255 NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF FROM 0.28 TO0.38 COMPRISING NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF FROM 0.28 TO 0.38 G/ML, COMPRISING BUDESONIDE KETOPROFENE SALE DI LISINA CEFIXIME ARTROSILENE 160 MG/2 ML SOLUZIONE INIETTABILE CEFIXORAL SUPRACEF UNIXIME SUPRAX 23/12/1996 23/12/2016 21/02/1997 21/02/2017 ACIDO IBANDRONICO BONDRONAT 21/04/1997 21/04/2017 PEGINTERFERONE ALFA 2A PEGASYS 22/05/1997 22/05/2017 QUETIAPINE SEROQUEL (XR) 27/05/1997 27/05/2017 ETORICOXIB ARCOXIA 08/07/1997 08/07/2017 INTERFERONE B 1A AVONEX 23/12/1997 23/12/2017 SYMBICORT SINESTIC OXIS 13/01/1998 13/01/2018 SYMBICORT SINESTIC 13/01/1998 13/01/2018 BUDESONIDE PULMAXAN 13/01/1998 13/01/2018 Elenco aggiornato al 27.11.2013 Pagina 4 di 15

EP989850 MI2005B019019 USE OF PRAMIPEXOLE IN THE TREATMENT OF RESTLESS LEGS PRAMIPEXOLO MIRAPEXIN 16/01/1998 16/01/2018 SYNDROME EP921796 MI2001B021095 TETRAHYDROLIPSTATIN CONTAINING COMPOSITIONS ORLISTAT XENICAL 24/01/1998 24/01/2018 EP1007121 TO2003B071700 INHALATION DEVICE SYMBICORT SINESTIC 13/03/1998 13/03/2018 EP969816 RM2005B048363 PREPARATION OF POWDER MOMETASONE AGGLOMERATES FUROATO ASMANEX 16/03/1998 16/03/2018 EP1017438 TO2004B072809 INHALATION DEVICE SYMBICORT SINESTIC 19/03/1998 19/03/2018 EP969815 RM2005B049653 PHARMACEUTICAL COMPOSITIONS ZEFFIX 20/03/1998 20/03/2018 EP876815 TO2002B068433 "DRUG DELIVERY SYSTEM FOR TWO OR MORE ACTIVE SUBSTANCES" ETONOGESTREL/ETINILE STRADIOLO NUVARING 09/04/1998 09/04/2018 EP920302 EP991641 EP994718 EP996621 EP1003486 EP996430 EP998480 MI2006B031755 TO2003B069262 TO2005B072159 TO2003B074119 MI2003B023025 MI2003B021180 MI2003B021181 PHARMACEUTICAL AEROSOL COMPOSITION CRYSTALLINE FORM OF OMEPRAZOLE SODIUM SALT GONADOTROPIN RELEASING HORMONE ANTAGONIST TRIAZOLO[4,5 D]PYRIMIDINE DERIVATIVES AS ANTI THROMBOTIC AGENTS PHARMACEUTICAL COMPOSITIONS CONTAINING AN EFFERVESCENT ACID BASE COUPLE NUCLEOTIDE ANALOG COMPOSITIONS NUCLEOTIDE ANALOG COMPOSITION AND SYNTHESIS METHOD BUDESONIDE CLENIL CLENIL JET BUDIAIR DESO MIFLO: SOLUZ PRESS PER INAL 10/06/1998 10/06/2018 OMEPRAZOLE NA LOSEC I.V. 11/06/1998 11/06/2018 GANIRELIX ORGALUTRAN 16/06/1998 16/06/2018 TICAGRELOR BRILIQUE 15/07/1998 15/07/2018 PIROXICAM BETACICLODESTRINA MELEVODOPA + CARBIDOPA BREXIN CICLADOL SIRIO SOLMEDO CPR EFFERVESCENTI 23/07/1998 23/07/2018 ADEFOVIR HEPSERA 23/07/1998 23/07/2018 TENOFOVIR DISOPROXIL FUMARATE VIREAD 23/07/1998 23/07/2018 Elenco aggiornato al 27.11.2013 Pagina 5 di 15

IT 1303684 IT1327107 EP1019058 EP0911038 EP1025083 EP1032396 EP1082304 EP1158958 EP1066049 EP1066059 MI2006B030048 TO2000B069880 RM2003B052101 TO2004B068714 RM2004B048110 MI2007B030279 MI2003B029801 RM2005B050040 PHARMACEUTICAL SUSPENSION COMPRISING NEVIRAPINE HEMIHYDRATE ANHYDROUS COMPOSITION COMPRISING LACTULOSE PROCESS FOR STEREOSELECTIVE SYNTHESIS OF PROSTACYCLIN DERIVATIVES FORMULAZIONI DI APOMORFINA IN SOLUZIONE STABILI NEL TEMPO STERILIZATION OF GLUCOCORTICOSTEROIDS NEW CRYSTALLINE POLYMORPHIC FORM OF 1 METHYL 5 P TOLUOYLPYRROLE 2 ACETAMIDOACETI ESTER (MED 15) COMPOSIZIONI FARMACEUTICHE PER IL TRATTAMENTO DEL DIABETE MELLITO DI TIPO II IMPROVED POWDERY PHARMACEUTICAL COMPOSITIONS FOR INHALATION PHARMACEUTICAL COMPOSITIONS FOR PROLONGED PEPTIDE RELEASE AND PREPARATION METHOD FORMULATIONS FOR PROTECTION OF PEG INTERFERON ALPHA CONJUGATES EP1067979 TO2004B071880 INHALATION DEVICE EP1087778 MI2006B019135 MEASURING PROBE FOR USE IN MEASURING THE TEMPERATURE OR MASS OF A FLOWING MEDIUM AND PROCESS FOR ITS MANUFACTURE. NEVIRAPINA VIRAMUNE 11/08/1998 11/08/2018 LATTULOSIO PARAFFINA TREPROSTINIL SODICO TRASITOL 06/10/1998 06/10/2018 REMODULIN SOLUZIONE PER INFUSIONE 26/10/1998 26/10/2018 APOMORFINA APOFIN 30/10/1998 30/10/2018 BUDESONIDE PULMAXAN 11/11/1998 11/11/2018 AMTOLMETINA GUACIL EUFANS 16/12/1998 16/12/2018 METFORMINA + GLIBENCLAMIDE O GLIBOMET 24/12/1998 24/12/2018 ATIMOS BOREAX LIFEROL: POLVERE PER INALAZIONE 05/03/1999 05/03/2019 LANREOTIDE IPSTYL 22/03/1999 22/03/2019 PEGINTERFERONE ALFA 2B PEGINTRON 24/03/1999 24/03/2019 SYMBICORT SINESTIC 30/03/1999 30/03/2019 RIBAVIRIN COPEGUS 29/05/1999 29/05/2019 Elenco aggiornato al 27.11.2013 Pagina 6 di 15

EP1085877 TO2008B069358 USE OF A COMPOSITION COMPRISING AND BUDESONIDE FOR THE PREVENTION OR TREATMENT OF AN ACUTE CONDITION OF ASTHMA SYMBICORT SINESTIC 10/06/1999 10/06/2019 EP1100481 MI2005B028925 PHARMACEUTICAL FORMULATIONS COMPRISING BECLOMETHASONE DIPROPIONATE FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE BECOLEX BIDICLIN CLIPPER: CPR RIVESTITE 20/07/1999 20/07/2019 EP1486209 MI2008B029137 PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE BECOLEX BIDICLIN CLIPPER: CLISMI 20/07/1999 20/07/2019 EP1102745 MI2004B028761 A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT ZOFENOPRIL CALCIO BIFRIL ZANTIPRESS ZOPRANOL ZOPRAZIDE BIFRIZIDE 30/07/1999 30/07/2019 EP1096937 EP1113831 TO2005B068384 TO2004B072801 SUSTAINED RELEASE RANOLAZINE FORMULATIONS SYRINGES FOR ADMINISTERING PASTY OR SEMI SOLID FORMULATIONS RANOLAZINA RANEXA 09/09/1999 09/09/2019 LANREOTIDE IPSTYL 17/09/1999 17/09/2019 EP970703 RM2003B051953 USE OF METAL CHELATING AGENTS TO STABILIZE PREPARATIONS CONTAINING INTERFERON INTERFERONE ALFA 2B RICOMBINANTE INTRON A 30/09/1999 30/09/2019 EP1070503 TO2005B071473 COMPOSITIONS COMPRISING LOW MOLECULAR WEIGHT HEPARIN BEMIPARINA SODICA IVOR 13/10/1999 13/10/2019 EP1126823 MI2007B024432 A PROCESS FOR THE PREPARATION OF STERILE THERAPEUTICALLY ACCEPTABLE BECLOMETHASONE DIPROPIONATE + SALBUTAMOLO BECLONEB CLENIL PRONTINAL CLENIL COMPOSITUM: SOSP PER NEBULIZZ 28/10/1999 28/10/2019 Elenco aggiornato al 27.11.2013 Pagina 7 di 15

EP1124544 EP1131051 EP1140117 EP1178808 EP2455083 EP1155015 EP1189620 EP1020460 EP1020461 Elenco dei brevetti non coperti da certificato complementare di protezione TO2003B070773 MI2006B023258 RM2003B050098 RM2012B050497 DRY POWDER PHARMACEUTICAL FORMULATION PRESSURISED METERED DOSE INHALERS (MDI) ACICLOVIR COMPOSITIONS CONTAINING DIMETHICONE COMPOSIZIONE FARMACEUTICA NON ACQUOSA PER USO CUTANEO PER IL TRATTAMENTO DELLA PSORIASI COMPRENDENTE UNA VITAMINA D, UN CORTICOSTEROIDE ED UN COMPONENTE DI SOLVENTE COMPOSIZIONE FARMACEUTICA PER USO CUTANEO COMPRENDENTE TO2013B071848 CALCIPOTRIOLO E BETAMETASONE PER IL TRATTAMENTO DELLA PSORIASI PROCESS FOR THE PRODUCTION OF TERT BUTYL (E) (6 2 4 (4 FLUOROPHENYL) 6 ISOPROPYL 2 TO2009B067185 METHYL(METHYLSULFONYL)AMIN O PYRIMIDIN 5 YL VINYL (4R,6S) 2,2 DIMETHYL 1,3 DIOXAN 4 YL)ACETATE FORMULATION COMPRISING TO2004B071461 TESTOSTERON UNDECANOATE AND CASTOR OIL THE SODIUM SALT OF THE ( ) TO2009B070518 ENANTIOMER OF OMEPRAZOLE MAGNESIUM SALT OF THE ( ) TO2009B070517 ENANTIOMER OF OMEPRAZOLE AND ITS USE BUDESONIDE RHINOCORT 03/11/1999 03/11/2019 BUDESONIDE ACICLOVIR CALCIPOTRIOLO /BETAMETASONE CALCIPOTRIOLO/BETAM ETASONE BUDIAIR DESO MIFLO: SOLUZ PRESS PER INAL ZOVIRAXLABIALE CYCLOVIRANLABIALE EFRIVIRALLABIALE DOVOBET UNGUENTO TOKEN UNGUENTO XAMIOL GEL DOVOBET GEL DOVOBET UNGUENTO TOKEN UNGUENTO XAMIOL GEL DOVOBET GEL 23/11/1999 23/11/2019 21/12/1999 21/12/2019 27/01/2000 27/01/2020 27/01/2000 27/01/2020 ROSUVASTATIN CRESTOR 15/02/2000 15/02/2020 TESTOSTERONE UNDECANOATO ANDRIOL 27/03/2000 27/03/2020 ESOMEPRAZOLE NA NEXIUM I.V. 18/04/2000 18/04/2020 ESOMEPRAZOLE MG NEXIUM COMPRESSE 18/04/2000 18/04/2020 EP1181930 UD2004B083348 PATCH KETOPROFENE KEPLAT 27/04/2000 27/04/2020 Elenco aggiornato al 27.11.2013 Pagina 8 di 15

IT1318540 PREPARAZIONI PER L'USO INTRAMUSCOLARE DI BISFOSFONATI DISODIO CLODRONATO, LIDOCAINA CLORIDRATO CLASTEON 26/05/2000 26/05/2020 EP1223918 TO2003B068959 EP1323701 TO2009B071989 EP1233948 EP1332206 EP1237551 MI2009B022761 MI2006B037460 TO2005B069438 PHARMACEUTICAL COMPOSITIONS COMPRISING A HMG COA REDUCTASE INHIBITOR METHODS FOR CRYSTALLIZATION OF HYDROXYCARBOXYLIC ACIDS STABLE POLYMORPH OF N (3 ETHYNYLPHENYLAMINO) 6,7 BIS(2 METHOXYETHOXY) 4 QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF RECOMBINANT ALPHA L IDURONIDASE, METHODS FOR PRODUCING AND PURIFYING THE SAME AND METHODS FOR TREATING DISEASES CAUSED BY DEFICIENCIES THEREOF PHARMACEUTICAL FORMULATIONS CONTAINING ZOLMITRIPTAN ROSUVASTATIN CRESTOR 04/08/2000 04/08/2020 ROSUVASTATIN CRESTOR 04/08/2000 04/08/2020 ERLOTINIB TARCEVA 09/11/2000 09/11/2020 LARONIDASE ALDURAZYME 09/11/2000 09/11/2020 ZOLMITRIPTAN ZOMIG 28/11/2000 28/11/2020 EP1238664 TO2007B069749 ADHESIVE PREPARATIONS KETOPROFENE KEPLAT 15/12/2000 15/12/2020 EP1244487 MI2007B019072 AEROSOL INHALER CLENIL JET CLENIL COMP JET SOLUZ PRESS PER INAL + CON EROGATORE JET SALBUTAMOLO 02/01/2001 02/01/2021 EP1250138 TO2005B073043 FULVESTRANT FORMULATION FULVESTRANT FASLODEX 08/01/2001 08/01/2021 EP1190712 UD2004B089376 ORAL ONCE DAILY TRAMADOL BEADS COMPOSITION TRAMADOL TRALODIE 14/02/2001 14/02/2021 Elenco aggiornato al 27.11.2013 Pagina 9 di 15

IT1304502 EP1272195 TO2005B073143 METODO PER PREPARARE UN GRANULATO EFFERVESCENTE COMPRENDENTE GLUCONATO DI FERRO, GRANULATO COSÌ OTTENUTO E COMPRESSE CHE LO CONTENGONO USE OF FULVESTRANT IN THE TREATMENT OF RESISTANT BREAST CANCER GLUCONATO FERROSO GLUCOFERRO CPR 29/03/2001 29/03/2021 FULVESTRANT FASLODEX 02/04/2001 02/04/2021 EP1272167 RM2008B049802 ROPINIROLE CONTAINING HYDROPHILIC/LIPHILIC POLYMERIC MATRIX DOSAGE FORMULATION ROPINIROLO REQUIP 12/04/2001 12/04/2021 EP1274406 EP1311285 EP1157689 EP1273292 EP1296645 EP1301201 MI2006B036540 MI2005B025559 MI2009B021956 MI2004B029338 MI2006B036039 MI2007B022525 PHARMACEUTICAL FORMULATIONS FOR DRY POWDER INHALERS IN THE FORM OF HARD PELLETS LIQUID PHARMACEUTICAL COMPOSITION CONTAINING AN ERYTHROPOIETIN DERIVATIVE STABLE PHARMACEUTICAL SOLUTION FORMULATIONS FOR PRESSURISED METERED DOSE INHALERS OPTIMISED FORMULATION OF TOBRAMYCIN FOR AEROSOLIZATION METHODS FOR TREATING INFLAMMATION MEDIATED CONDITIONS OF THE EYE TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II + O O METOSSIPOLIETILENGLIC OLE EPOETINA BETA O TOBRAMICINA ALABASTER FORMODUAL FOSTER INUVER ATIMOS BOREAX LIFEROL: POLVERE PER INALAZIONE 17/04/2001 17/04/2021 MIRCERA 08/05/2001 08/05/2021 ATIMOS BOREAX LIFEROL FORADIL EOLUS: SOLUZ PRESS PER INAL ACTITOB BRAMITOB TOBRINEB 18/05/2001 18/05/2021 02/07/2001 02/07/2021 DESAMETASONE OZURDEX 03/07/2001 03/07/2021 ALGLUCOSIDASE ALFA MYOZYME 10/07/2001 10/07/2021 Elenco aggiornato al 27.11.2013 Pagina 10 di 15

EP1331927 TO2008B068153 COMPOSIZIONE TOPICA CONTENENTE ALMENO UNA VITAMINA D O UN ANALOGO DI UNA VITAMINA D E ALMENO UN CORTICOSTEROIDE CALCIPOTRIOLO /BETAMETASONE XAMIOL GEL DOVOBET GEL 26/09/2001 26/09/2021 EP1292281 MI2004B034406 NOVEL TIOTROPIUM CONTAINING INHALATION POWDER TIOTROPIO BROMIDE SPIRIVA HANDIHALER 28/09/2001 28/09/2021 IT1340100 EP1326862 EP1328538 EP1333819 MI2004B034837 TO2008B072720 MI2007B034598 CRYSTALLINE MONOHYDRATE OF TIOTROPIUMBROMIDE, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF IN THE PRODUCTION OF A MEDICAMENT PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF 7 SUBSTITUTED ANTIESTROGENS COMPOSIZIONI FARMACEUTICHE PER IL TRATTAMENTO DELL'IPERTENSIONE ARTERIOSA INHALATIVE SOLUTION FORMULATION CONTAINING A TIOTROPIUM SALT TIOTROPIO BROMIDE MONOIDRATO SPIRIVA 28/09/2001 28/09/2021 FULVESTRANT FASLODEX 09/10/2001 09/10/2021 ENALAPRIL MALEATO/LERCANIDIPIN A CLORIDRATO CORIPREN ATOVER ZANIPRIL LERCAPREL 16/10/2001 16/10/2021 TIOTROPIO BROMIDE SPIRIVA RESPIMAT 24/10/2001 24/10/2021 EP1339409 TO2008B070491 USE OF ROSUVASTATIN (ZD 4522) IN THE TREATMENT OF HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA ROSUVASTATIN CRESTOR 16/11/2001 16/11/2021 EP1339438 EP1343808 MI2005B034814 MI2006B036555 PREVENTING TRANSPLANT REJECTION IN THE EYE PROCESS FOR THE SYNTHESIS OF AN LHRH PEPTIDE DESAMETASONE OZURDEX 28/11/2001 28/11/2021 TRIPTORELINA DECAPEPTYL 19/12/2001 19/12/2021 EP1467712 MI2011B030858 BILAYER PHARMACEUTICAL TABLET COMPRISING TELMISARTAN AND HYDROCHLOROTHIAZIDE TELMISARTAN + IDROCLOROTIAZIDE MICARDISPLUS 16/01/2002 16/01/2022 Elenco aggiornato al 27.11.2013 Pagina 11 di 15

IT 1334343 EP1355636 EP1363928 EP1505066 TO2008B071506 MI2005B028581 TO2007B068262 TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING NON STEROIDAL ANTIPHLOGISTIC AGENTS CONTAINING CARBOXYL GROUPS, AND A METHOD FOR THE PRODUCTION OF THE SAME PROCESS FOR THE PREPARATION OF (E) 5 (2 BROMOVINYL) 2' DEOXYURIDINE POLYMORPH OF ACID 4 [2 [4 [1 (2 ETHOXYETHYL) 1H BENZIMIDAZOLE 2 IL] 1 PIPERIDINYL]ETHYL] ALPHA, ALPHA DIMETHYL BENZENEACETIC IBUPROFENE IBUPAS 17/01/2002 17/01/2022 BRIVUDINA BRIVIRAC ZECOVIR 21/02/2002 21/02/2022 BILASTINA ROBILAS AYRINAL 19/04/2002 19/04/2022 EP1238677 TO2006B067806 PARENTERAL FAT EMULSIONS COMPRISING EDETATE AS PRESERVATIVE PROPOFOL DIPRIVAN 02/05/2002 02/05/2022 FORMULAZIONI DI BISFOSFONATI A USO INIETTABILE CLODRONATO DISODICO CLODY 13/05/2002 13/05/2022 EP1407008 RM2009B048278 INFLUENZA VACCINE COMPOSITION INFLUENZA ANTIGEN FLUARIX 29/05/2002 29/05/2022 EP1392319 EP1374906 RM2011B049410 MI2007B028216 HYPOTENSIVE LIPID (PROSTAGLANDIN) AND TIMOLOL COMPOSITIONS AND METHODS OF USING SAME A PROCESS FOR THE PREPARATION OF PIROXICAM: BETA CYCLODEXTRIN INCLUSION COMPOUNDS BIMATOPROST / TIMOLOLO MALEATO PIROXICAM BETACICLODESTRINA GANFORT 30/05/2002 30/05/2022 BREXIN CICLADOL CPR, BUSTINE, SUPP. 17/06/2002 17/06/2022 EP1386630 MI2006B028898 POWDER INHALER EP1273581 TO2005B069439 NEW PROCESS FOR THE PREPARATION OF THE TRIHYDRATE OF THE MAGNESIUM SALT OF S OMEPRAZOLE + O ALABASTER, FORMODUAL, FOSTER, INUVER: POLVERE PER INALAZIONE 31/07/2002 31/07/2022 ESOMEPRAZOLE MG NEXIUM COMPRESSE 03/09/2002 03/09/2022 Elenco aggiornato al 27.11.2013 Pagina 12 di 15

EP1435915 EP1455781 TO2008B073184 TO2008B073117 ORAL DOSAGE FORMS FOR PROPIVERINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS WITH AN EXTENDED RELEASE OF THE ACTIVE INGREDIENT USE OF ANASTROZOLE FOR THE TREATMENT OF POST MENOPAUSAL WOMEN HAVING EARLY BREAST CANCER EP1474117 TO2009B069412 COMPOSITION FOR INHALATION EP1480679 EP1485127 TO2007B071180 RM2011B050073 PHARMACEUTICAL FORMULATION OF IRESSA COMPRISING A WATER SOLUBLE CELLULOSE DERIVATIVE ADMINISTRATIONOF AGENTS FOR THE TREATMENTOF INFLAMMATION PROPIVERINA CLORIDRATO MICTONORM 08/10/2002 08/10/2022 ANASTROZOLE ARIMIDEX 06/12/2002 06/12/2022 SYMBICORT SINESTIC 29/01/2003 29/01/2023 GEFITINIB IRESSA 24/02/2003 24/02/2023 NATALIZUMAB TYSABRY 25/02/2003 25/02/2023 EP1494647 MI2006B035844 EP1539711 TO2011B069304 EP1596870 MI2011B025554 EP1575565 TO2010B068746 EP1546119 TO2009B072173 EP1393721 TO2009B067892 EP1558648 RM2012B048801 PROCESS FOR PREPARATION OF A STERILE SUSPENSION OF CORTICOSTEROID PARTICLES FOR THE ADMINISTRATION BY INHALATION PROCESS FOR PREPARING THE CALCIUM SALT OF ROSUVASTATIN HIGH DOSE IBANDRONATE FORMULATION MODIFIED RELEASE TABLET OF BUPROPION HYDROCHLORIDE PROCESS FOR THE PREPARATION OF 4 (3'CHLORO 4' FLUOROANILINO) 7 METHOXY 6 (3 MORPHOLINOPROPOXY) QUINAZOLINE DOSAGE FORM OF POWDER AGGLOMERATES HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 + SALBUTAMOLO BECLONEB CLENIL PRONTINAL CLENIL COMPOSITUM: SOSP PER NEBULIZZ 15/04/2003 15/04/2023 ROSUVASTATIN CRESTOR 07/08/2003 07/08/2023 ACIDO IBANDRONICO BONDRONAT 07/08/2003 07/08/2023 BUPROPIONE CLORIDRATO WELLBUTRIN ELONTRIL 08/08/2003 08/08/2023 GEFITINIB IRESSA 06/09/2003 06/09/2023 MOMETASONE FUROATO ASMANEX 15/09/2003 15/09/2023 OFATUMUMAB ARZERRA 17/10/2003 17/10/2023 Elenco aggiornato al 27.11.2013 Pagina 13 di 15

EP1581193 MI2012B025961 BIODEGRADABLE OCULAR IMPLANT DESAMETASONE OZURDEX 07/01/2004 07/01/2024 EP1454647 TO2006B068883 INHALATION DEVICE EP1633727 EP1654263 EP1493745 EP1651213 EP1729819 EP1732548 EP1781260 EP1830816 TO2010B070012 RM2011B048799 TO2012B070483 MI2009B031121 TO2008B072212 MI2011B027695 MI2011B019967 TO2012B072228 IMPROVED PRODUCTION OF THE ROSUVASTATIN CALCIUM SALT PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE IV INHIBITOR NEW CRYSTALLINE AND AMORPHOUS FORM OF A TRIAZOLO(4,5 D)PYRIMIDINE COMPOUND USE OF ANGIOTENSIN II RECEPTOR ANTAGONISTS, ESPECIALLY TELMISARTAN, IN ORDER TO INCREASE INSULIN SENSITIVITY X RAY VISIBLE DRUG DELIVERY DEVICE METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS EXTENDED RELEASE TABLET FORMULATION CONTAINING PRAMIPEXOLE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF SYMBICORT SINESTIC 02/04/2004 02/04/2024 ROSUVASTATIN CRESTOR 03/06/2004 03/06/2024 SITAGLIPTIN JANUVIA 18/06/2004 18/06/2024 TICAGRELOR BRILIQUE 30/06/2004 30/06/2024 TELMISARTAN + AMLODIPINA ETONOGESTREL IMPLANT TWYNSTA 24/07/2004 24/07/2024 IMPLANON NEXPLANON 14/03/2005 14/03/2025 4 AMINOPYRIDINE FAMPYRA 11/04/2005 11/04/2025 PRAMIPEXOLO MIRAPEXIN ER 25/07/2005 25/07/2025 ESOMEPRAZOLE MG NEXIUM BUSTINE 20/12/2005 20/12/2025 Elenco aggiornato al 27.11.2013 Pagina 14 di 15

EP1868645 Elenco dei brevetti non coperti da certificato complementare di protezione MI2012B023735 MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE PROTEIN CONJUGATE COMPOSITION POLISACCARIDE PNEUMOCOCCICO DEI SIEROTIPI 1,3,4,5,6A,6B,7F,9V,14,1 8C,19A, 19F,23F CONIUGATO E ADSORBITO PREVENAR 13 31/03/2006 31/03/2026 EP2073791 MI2011B021774 CAPECITABINE PEDIATRIC TABLETS CAPECITABINA XELODA 26/09/2007 26/09/2027 EP2036549 TO2010B070108 NOVEL COMPOSITION SYMBICORT 17/10/2008 17/10/2028 Elenco aggiornato al 27.11.2013 Pagina 15 di 15