Elenco dei brevetti non coperti da certificato complementare di protezione

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1 ITA EP N TRADUZIONE EP TITOLO PRINCIPIO ATTIVO MARCHIO DEPOSITO SCADENZA EP EP EP RM2002B MI2008B RM1998B EP MI1997B EP MI2002B EP RM1996B EP EP EP EP EP EP RM1995B MI1997B RM2000B MI1996B TO2003B UD1999B HEPATITIS VACCINS CONTAINING 3-0 DEACYLATED MONOPHOSPHORYL LIPID A HUMAN GROWTH HORMONE AQUEOUS FORMULATION SUSTAINED RELEASE TABLETS CONTAINING BUPROPION DRUGS CONTAINING DIPHOSPHONIC ACIDS AND SALTS THEREOF VACCINES AGAINST GROUP C NEISSERIA MENINGITIDIS INJECTION SOLUTIONS CONTAINING MESNA STABILIZED SOLUTIONS OF ALKYLPHOSPHOCHOLINE IN GLYCEROLALKYLETHER A NOVEL ARYLPROPIONIC DERIVATIVE, A PROCESS FOR THE PREPARATION AND THE USETHEREOF AS AN ANALGESIC AGENT COMBINATION OF ATOVAQUONE WITH PROGUANIL FOR THE TREATMENT OF PROTOZOAL INFECTIONS N-OXYCARBONYL SUBSTITUTED 5'- DEOXY-5-FLUOROCYTIDINES ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS STABLE ORAL CI-981 FORMULATION AND PROCESS OF PREPARING SAME VACCINO ANTIEPATITE B - (RDNA) - ADIUVATO ADSORBITO ORMONE DELLA CRESCITA UMANA RICOMBINANTE BUPROPIONE CLORIDRATO FENDRIX 24/03/ /03/2013 NUTROPIN 29/07/ /07/2013 WELLBUTRIN ELONTRIL 13/08/ /08/2013 ACIDO IBANDRONICO BONDRONAT 19/08/ /08/2013 VACCINO MENINGOCOCCICO GRUPPO C-TT CONIUGATO MESNA NEISVAC-C 30/08/ /08/2013 MESNEX UROMITEXAN 13/09/ /09/2013 MILTEFOSINE MILTEX 13/09/ /09/2013 DEXKETOPROFENE TROMETAMOLO ATOVAQUONE E PROGUANILE DESKETO ENANTYUM KETESSE MALARONE MALARONE BAMBINI 09/11/ /11/ /11/ /11/2013 CAPECITABINA XELODA 01/12/ /12/2013 FROVATRIPTAN AURADOL RILAMIG 16/12/ /12/2013 ATORVASTATINA TOTALIP 20/12/ /12/2013 Elenco aggiornato al Pagina 1 di 15

2 IT EP MI1999B RECOMBINANT ANTI-VLA4 ANTIBODY MOLECULES EP MI1997B ARYLALKANOIC ACID RESOLUTION EP MI2003B STABILIZED PHARMACEUTICAL COMPOSITION CONTAINING BUPROPION MYCOPHENOLATE MOFETIL HIGH DOSE ORAL SUSPENSIONS NATALIZUMAB TYSABRI 07/01/ /01/2014 DEXKETOPROFENE TROMETAMOLO BUPROPIONE CLORIDRATO DESKETO ENANTYUM KETESSE WELLBUTRIN ELONTRIL 03/03/ /03/ /07/ /07/2014 EP MI2005B MICOFENOLATO MOFETILE CELLCEPT 27/09/ /09/2014 EP TO2002B PROCESS I SYMBICORT SINESTIC 29/09/ /09/2014 EP TO2002B PROCESS II SYMBICORT 29/09/ /09/2014 EP MI2002B HIV PROTEASE INHIBITORS NELFINAVIR VIRACEPT 07/10/ /10/2014 EP TO1997B LEVOBUPIVACAINE USEFUL FOR MANAGING CHRONIC PAIN LEVOBUPIVACAINE CHIROCAINE 13/10/ /10/2014 EP TO1997B ANALGESIC AGENT AND ITS USE LEVOBUPIVACAINE CHIROCAINE 13/10/ /10/2014 EP TO2002B ANALGESIC AGENT AND ITS USE LEVOBUPIVACAINE CHIROCAINE 13/10/ /10/2014 EP MI2002B IMPROVED INTERFERON POLYMER PEGINTERFERONE ALFA- CONJUGATES 2B PEGINTRON 10/11/ /11/2014 EP MI2000B PROCESS FOR PRODUCING S(+)- IBUPROFEN PARTICLES DEXIBUPROFENE SERACTIL CP 26/01/ /01/2015 EP EP EP EP MI1999B TO2003B MI2001B MI2001B ORAL LIQUID COMPOSITIONS CONTAINING PAROXETINE RESINATE FORMULAZIONI FARMACEUTICHE A BASE DI CARBOSSIMETILCISTEINA SALE DI LISINA OIL IN WATER EMULSIONS CONTAINING PROPOFOL AND DISODIUM EDETATE TREATMENT OF PARTIAL GROWTH HORMONE INSENSITIVITY SYNDROME PROCESS FOR PRODUCING ALPHA- INTERFERON PAROXETINA S- CARBOSSIMETILCISTEINA SALE DI LISINA MONOIDRATO EUTIMIL SEROXAT SEREUPIN 30/01/ /01/2015 FLUIFORT SCIROPPO 08/02/ /02/2015 PROPOFOL DIPRIVAN 17/03/ /03/2015 IGF-I INCRELEX 24/03/ /03/2015 INTERFERONE ALFA-2A RICOMBINANTE ROFERON-A 29/03/ /03/2015 Elenco aggiornato al Pagina 2 di 15

3 EP EP EP EP EP Elenco dei brevetti non coperti da certificato complementare di protezione RM1999B TO2011B MI2006B MI2002B RM2000B PROCESS FOR THE DIASTEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES HUMANIZED ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS SUSTAINED RELEASE OF PEPTIDES FROM PHARMACEUTICAL COMPOSITIONS STABLE, AQUEOUS ALFA INTERFERON SOLUTION FORMULATIONS EP RM2002B HEPATITIS B VACCINE EP MI1999B INTERFERON SOLUTION EP EP EP EP EP EP MI2006B TO2003B TO2002B TO1996B MI2003B MI2002B PROCESS FOR PRODUCING ERYTHROPOIETIN FREE FROM ANIMAL PROTEINS ONE POT SYNTHESIS OF 2- OXAZOLIDINONE DERIVATIVES ONE POT SYNTHESIS OF 2- OXAZOLIDINONE DERIVATIVES PURIFIED HEPARIN FRACTIONS, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME A GLIBENCLAMIDE-METFORMIN COMBINATION FOR THE TREATMENT OF DIABETES MELLITUS OF RETROVIRAL PROTEASE INHIBITING COMPOUNDS LAMIVUDINA ZEFFIX 21/04/ /04/2015 ESOMEPRAZOLE MG NEXIUM COMPRESSE 03/07/ /07/2015 PALIVIZUMAB SYNAGIS 09/08/ /08/2015 LANREOTIDE IPSTYL 31/08/ /08/2015 INTERFERONE ALFA-2B RICOMBINANTE INTERFERONE ALFA-2A RICOMBINANTE METOSSIPOLIETILENGLIC OLE-EPOETINA BETA INTRON A 10/10/ /10/2015 FENDRIX 15/02/ /02/2016 ROFERON-A 30/03/ /03/2016 MIRCERA 10/05/ /05/2016 ZOLMITRIPTAN ZOMIG 02/08/ /08/2016 ZOLMITRIPTAN ZOMIG 02/08/ /08/2016 NADROPARINA CALCICA GLIBENCLAMIDE; METFORMINA FRAXIPARINA FRAXODI SELEPARINA SELEDIE 21/08/ /08/2016 GLICONORM 07/11/ /11/2016 LOPINAVIR/RITONAVIR KALETRA 06/12/ /12/2016 Elenco aggiornato al Pagina 3 di 15

4 EP EP EP Elenco dei brevetti non coperti da certificato complementare di protezione MI2003B MI2002B MI2012B PARENTERAL PHARMACEUTICAL COMPOSITIONS CONTAINING ALKYLAMMONIUM SALTS OF 2- ARYLP TABLETS CONTAINING BETA-LACTAM ANTIBIOTIC AND PROCESS FOR PRODUCING THE SAME ORAL PHARMACEUTICAL PREPARATION CONTAINING IBANDRONAT EP MI2003B INTERFERON CONJUGATES EP EP EP EP EP EP SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS TO2002B COMPRISING A DIBENZOTHIAZEPINE DER SUBSTITUTED PYRIDINES AS RM2003B SELECTIVE CYCLOOXYGENASE-2 INHIBITORS STABLE LIQUID INTERFERON MI2012B FORMULATIONS NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF 0.28 TO 0.38 TO2011B G/ML, A PROCESS FOR PREPARING THE FORMULATION AND THE USE THEREOF TO2004B TO2008B NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF FROM 0.28 TO0.38 COMPRISING NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF FROM 0.28 TO 0.38 G/ML, COMPRISING BUDESONIDE KETOPROFENE SALE DI LISINA CEFIXIME ARTROSILENE 160 MG/2 ML SOLUZIONE INIETTABILE CEFIXORAL SUPRACEF UNIXIME SUPRAX 23/12/ /12/ /02/ /02/2017 ACIDO IBANDRONICO BONDRONAT 21/04/ /04/2017 PEGINTERFERONE ALFA- 2A PEGASYS 22/05/ /05/2017 QUETIAPINE SEROQUEL (XR) 27/05/ /05/2017 ETORICOXIB ARCOXIA 08/07/ /07/2017 INTERFERONE B-1A AVONEX 23/12/ /12/2017 SYMBICORT SINESTIC OXIS 13/01/ /01/2018 SYMBICORT SINESTIC 13/01/ /01/2018 BUDESONIDE PULMAXAN 13/01/ /01/2018 Elenco aggiornato al Pagina 4 di 15

5 EP Elenco dei brevetti non coperti da certificato complementare di protezione MI2005B EP MI2001B USE OF PRAMIPEXOLE IN THE TREATMENT OF RESTLESS LEGS SYNDROME TETRAHYDROLIPSTATIN CONTAINING COMPOSITIONS EP TO2003B INHALATION DEVICE EP RM2005B PREPARATION OF POWDER AGGLOMERATES EP TO2004B INHALATION DEVICE PRAMIPEXOLO MIRAPEXIN 16/01/ /01/2018 ORLISTAT XENICAL 24/01/ /01/2018 MOMETASONE FUROATO SYMBICORT SINESTIC 13/03/ /03/2018 ASMANEX 16/03/ /03/2018 SYMBICORT SINESTIC 19/03/ /03/2018 EP RM2005B PHARMACEUTICAL COMPOSITIONS ZEFFIX 20/03/ /03/2018 EP TO2002B "DRUG DELIVERY SYSTEM FOR TWO OR MORE ACTIVE SUBSTANCES" ETONOGESTREL/ETINILE STRADIOLO NUVARING 09/04/ /04/2018 EP EP EP EP EP EP EP MI2006B TO2003B TO2005B TO2003B MI2003B MI2003B MI2003B PHARMACEUTICAL AEROSOL COMPOSITION CRYSTALLINE FORM OF OMEPRAZOLE SODIUM SALT GONADOTROPIN RELEASING HORMONE ANTAGONIST TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS ANTI-THROMBOTIC AGENTS PHARMACEUTICAL COMPOSITIONS CONTAINING AN EFFERVESCENT ACID-BASE COUPLE NUCLEOTIDE ANALOG COMPOSITIONS NUCLEOTIDE ANALOG COMPOSITION AND SYNTHESIS METHOD BUDESONIDE CLENIL CLENIL JET BUDIAIR DESO MIFLO: SOLUZ PRESS PER INAL 10/06/ /06/2018 OMEPRAZOLE NA LOSEC I.V. 11/06/ /06/2018 GANIRELIX ORGALUTRAN 16/06/ /06/2018 TICAGRELOR BRILIQUE 15/07/ /07/2018 PIROXICAM BETACICLODESTRINA MELEVODOPA + CARBIDOPA BREXIN CICLADOL SIRIO SOLMEDO CPR EFFERVESCENTI 23/07/ /07/2018 ADEFOVIR HEPSERA 23/07/ /07/2018 TENOFOVIR DISOPROXIL FUMARATE VIREAD 23/07/ /07/2018 Elenco aggiornato al Pagina 5 di 15

6 IT IT EP EP EP EP EP EP EP EP MI2006B TO2000B RM2003B TO2004B RM2004B MI2007B MI2003B RM2005B PHARMACEUTICAL SUSPENSION COMPRISING NEVIRAPINE HEMIHYDRATE ANHYDROUS COMPOSITION COMPRISING LACTULOSE PROCESS FOR STEREOSELECTIVE SYNTHESIS OF PROSTACYCLIN DERIVATIVES FORMULAZIONI DI APOMORFINA IN SOLUZIONE STABILI NEL TEMPO STERILIZATION OF GLUCOCORTICOSTEROIDS NEW CRYSTALLINE POLYMORPHIC FORM OF 1-METHYL-5-P- TOLUOYLPYRROLE-2- ACETAMIDOACETI ESTER (MED 15) COMPOSIZIONI FARMACEUTICHE PER IL TRATTAMENTO DEL DIABETE MELLITO DI TIPO II IMPROVED POWDERY PHARMACEUTICAL COMPOSITIONS FOR INHALATION PHARMACEUTICAL COMPOSITIONS FOR PROLONGED PEPTIDE RELEASE AND PREPARATION METHOD FORMULATIONS FOR PROTECTION OF PEG-INTERFERON ALPHA CONJUGATES EP TO2004B INHALATION DEVICE EP MI2006B MEASURING PROBE FOR USE IN MEASURING THE TEMPERATURE OR MASS OF A FLOWING MEDIUM AND PROCESS FOR ITS MANUFACTURE. NEVIRAPINA VIRAMUNE 11/08/ /08/2018 LATTULOSIO - PARAFFINA TREPROSTINIL SODICO TRASITOL 06/10/ /10/2018 REMODULIN SOLUZIONE PER INFUSIONE 26/10/ /10/2018 APOMORFINA APOFIN 30/10/ /10/2018 BUDESONIDE PULMAXAN 11/11/ /11/2018 AMTOLMETINA GUACIL EUFANS 16/12/ /12/2018 METFORMINA + GLIBENCLAMIDE O GLIBOMET 24/12/ /12/2018 ATIMOS BOREAX LIFEROL: POLVERE PER INALAZIONE 05/03/ /03/2019 LANREOTIDE IPSTYL 22/03/ /03/2019 PEGINTERFERONE ALFA- 2B PEGINTRON 24/03/ /03/2019 SYMBICORT SINESTIC 30/03/ /03/2019 RIBAVIRIN COPEGUS 29/05/ /05/2019 Elenco aggiornato al Pagina 6 di 15

7 EP TO2008B USE OF A COMPOSITION COMPRISING AND BUDESONIDE FOR THE PREVENTION OR TREATMENT OF AN ACUTE CONDITION OF ASTHMA SYMBICORT SINESTIC 10/06/ /06/2019 EP MI2005B PHARMACEUTICAL FORMULATIONS COMPRISING BECLOMETHASONE DIPROPIONATE FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE BECOLEX BIDICLIN CLIPPER: CPR RIVESTITE 20/07/ /07/2019 EP MI2008B PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE BECOLEX BIDICLIN CLIPPER: CLISMI 20/07/ /07/2019 EP MI2004B A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT ZOFENOPRIL CALCIO BIFRIL ZANTIPRESS ZOPRANOL ZOPRAZIDE BIFRIZIDE 30/07/ /07/2019 EP EP TO2005B TO2004B SUSTAINED RELEASE RANOLAZINE FORMULATIONS SYRINGES FOR ADMINISTERING PASTY OR SEMI-SOLID FORMULATIONS RANOLAZINA RANEXA 09/09/ /09/2019 LANREOTIDE IPSTYL 17/09/ /09/2019 EP RM2003B USE OF METAL CHELATING AGENTS TO STABILIZE PREPARATIONS CONTAINING INTERFERON INTERFERONE ALFA-2B RICOMBINANTE INTRON A 30/09/ /09/2019 EP TO2005B COMPOSITIONS COMPRISING LOW MOLECULAR WEIGHT HEPARIN BEMIPARINA SODICA IVOR 13/10/ /10/2019 EP MI2007B A PROCESS FOR THE PREPARATION OF STERILE THERAPEUTICALLY ACCEPTABLE BECLOMETHASONE DIPROPIONATE + SALBUTAMOLO BECLONEB CLENIL PRONTINAL CLENIL COMPOSITUM: SOSP PER NEBULIZZ 28/10/ /10/2019 Elenco aggiornato al Pagina 7 di 15

8 EP EP EP EP EP EP EP EP EP Elenco dei brevetti non coperti da certificato complementare di protezione TO2003B MI2006B RM2003B RM2012B DRY POWDER PHARMACEUTICAL FORMULATION PRESSURISED METERED DOSE INHALERS (MDI) ACICLOVIR COMPOSITIONS CONTAINING DIMETHICONE COMPOSIZIONE FARMACEUTICA NON ACQUOSA PER USO CUTANEO PER IL TRATTAMENTO DELLA PSORIASI COMPRENDENTE UNA VITAMINA D, UN CORTICOSTEROIDE ED UN COMPONENTE DI SOLVENTE COMPOSIZIONE FARMACEUTICA PER USO CUTANEO COMPRENDENTE TO2013B CALCIPOTRIOLO E BETAMETASONE PER IL TRATTAMENTO DELLA PSORIASI PROCESS FOR THE PRODUCTION OF TERT-BUTYL (E)-( (4- FLUOROPHENYL)-6-ISOPROPYL-2- TO2009B METHYL(METHYLSULFONYL)AMIN O PYRIMIDIN-5-YL VINYL (4R,6S)-2,2- DIMETHYL 1,3 DIOXAN-4- YL)ACETATE FORMULATION COMPRISING TO2004B TESTOSTERON UNDECANOATE AND CASTOR OIL THE SODIUM SALT OF THE (-)- TO2009B ENANTIOMER OF OMEPRAZOLE MAGNESIUM SALT OF THE (-)- TO2009B ENANTIOMER OF OMEPRAZOLE AND ITS USE BUDESONIDE RHINOCORT 03/11/ /11/2019 BUDESONIDE ACICLOVIR CALCIPOTRIOLO /BETAMETASONE CALCIPOTRIOLO/BETAM ETASONE BUDIAIR DESO MIFLO: SOLUZ PRESS PER INAL ZOVIRAXLABIALE CYCLOVIRANLABIALE EFRIVIRALLABIALE DOVOBET UNGUENTO TOKEN UNGUENTO XAMIOL GEL DOVOBET GEL DOVOBET UNGUENTO TOKEN UNGUENTO XAMIOL GEL DOVOBET GEL 23/11/ /11/ /12/ /12/ /01/ /01/ /01/ /01/2020 ROSUVASTATIN CRESTOR 15/02/ /02/2020 TESTOSTERONE UNDECANOATO ANDRIOL 27/03/ /03/2020 ESOMEPRAZOLE NA NEXIUM I.V. 18/04/ /04/2020 ESOMEPRAZOLE MG NEXIUM COMPRESSE 18/04/ /04/2020 EP UD2004B PATCH KETOPROFENE KEPLAT 27/04/ /04/2020 Elenco aggiornato al Pagina 8 di 15

9 IT PREPARAZIONI PER L'USO INTRAMUSCOLARE DI BISFOSFONATI DISODIO CLODRONATO, LIDOCAINA CLORIDRATO CLASTEON 26/05/ /05/2020 EP TO2003B EP TO2009B EP EP EP MI2009B MI2006B TO2005B PHARMACEUTICAL COMPOSITIONS COMPRISING A HMG COA REDUCTASE INHIBITOR METHODS FOR CRYSTALLIZATION OF HYDROXYCARBOXYLIC ACIDS STABLE POLYMORPH OF N-(3- ETHYNYLPHENYLAMINO)-6,7-BIS(2- METHOXYETHOXY)-4- QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF RECOMBINANT ALPHA-L- IDURONIDASE, METHODS FOR PRODUCING AND PURIFYING THE SAME AND METHODS FOR TREATING DISEASES CAUSED BY DEFICIENCIES THEREOF PHARMACEUTICAL FORMULATIONS CONTAINING ZOLMITRIPTAN ROSUVASTATIN CRESTOR 04/08/ /08/2020 ROSUVASTATIN CRESTOR 04/08/ /08/2020 ERLOTINIB TARCEVA 09/11/ /11/2020 LARONIDASE ALDURAZYME 09/11/ /11/2020 ZOLMITRIPTAN ZOMIG 28/11/ /11/2020 EP TO2007B ADHESIVE PREPARATIONS KETOPROFENE KEPLAT 15/12/ /12/2020 EP MI2007B AEROSOL INHALER CLENIL JET CLENIL COMP JET SOLUZ PRESS PER INAL + CON EROGATORE JET SALBUTAMOLO 02/01/ /01/2021 EP TO2005B FULVESTRANT FORMULATION FULVESTRANT FASLODEX 08/01/ /01/2021 EP UD2004B ORAL ONCE DAILY TRAMADOL BEADS COMPOSITION TRAMADOL TRALODIE 14/02/ /02/2021 Elenco aggiornato al Pagina 9 di 15

10 IT EP TO2005B METODO PER PREPARARE UN GRANULATO EFFERVESCENTE COMPRENDENTE GLUCONATO DI FERRO, GRANULATO COSÌ OTTENUTO E COMPRESSE CHE LO CONTENGONO USE OF FULVESTRANT IN THE TREATMENT OF RESISTANT BREAST CANCER GLUCONATO FERROSO GLUCOFERRO CPR 29/03/ /03/2021 FULVESTRANT FASLODEX 02/04/ /04/2021 EP RM2008B ROPINIROLE-CONTAINING HYDROPHILIC/LIPHILIC POLYMERIC MATRIX DOSAGE FORMULATION ROPINIROLO REQUIP 12/04/ /04/2021 EP EP EP EP EP EP MI2006B MI2005B MI2009B MI2004B MI2006B MI2007B PHARMACEUTICAL FORMULATIONS FOR DRY POWDER INHALERS IN THE FORM OF HARD-PELLETS LIQUID PHARMACEUTICAL COMPOSITION CONTAINING AN ERYTHROPOIETIN DERIVATIVE STABLE PHARMACEUTICAL SOLUTION FORMULATIONS FOR PRESSURISED METERED DOSE INHALERS OPTIMISED FORMULATION OF TOBRAMYCIN FOR AEROSOLIZATION METHODS FOR TREATING INFLAMMATION-MEDIATED CONDITIONS OF THE EYE TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II + O O METOSSIPOLIETILENGLIC OLE-EPOETINA BETA O TOBRAMICINA ALABASTER FORMODUAL FOSTER INUVER ATIMOS BOREAX LIFEROL: POLVERE PER INALAZIONE 17/04/ /04/2021 MIRCERA 08/05/ /05/2021 ATIMOS BOREAX LIFEROL FORADIL EOLUS: SOLUZ PRESS PER INAL ACTITOB BRAMITOB TOBRINEB 18/05/ /05/ /07/ /07/2021 DESAMETASONE OZURDEX 03/07/ /07/2021 ALGLUCOSIDASE ALFA MYOZYME 10/07/ /07/2021 Elenco aggiornato al Pagina 10 di 15

11 EP TO2008B COMPOSIZIONE TOPICA CONTENENTE ALMENO UNA VITAMINA D O UN ANALOGO DI UNA VITAMINA D E ALMENO UN CORTICOSTEROIDE CALCIPOTRIOLO /BETAMETASONE XAMIOL GEL DOVOBET GEL 26/09/ /09/2021 EP MI2004B NOVEL TIOTROPIUM-CONTAINING INHALATION POWDER TIOTROPIO BROMIDE SPIRIVA HANDIHALER 28/09/ /09/2021 IT EP EP EP MI2004B TO2008B MI2007B CRYSTALLINE MONOHYDRATE OF TIOTROPIUMBROMIDE, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF IN THE PRODUCTION OF A MEDICAMENT PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF 7- SUBSTITUTED ANTIESTROGENS COMPOSIZIONI FARMACEUTICHE PER IL TRATTAMENTO DELL'IPERTENSIONE ARTERIOSA INHALATIVE SOLUTION FORMULATION CONTAINING A TIOTROPIUM SALT TIOTROPIO BROMIDE MONOIDRATO SPIRIVA 28/09/ /09/2021 FULVESTRANT FASLODEX 09/10/ /10/2021 ENALAPRIL MALEATO/LERCANIDIPIN A CLORIDRATO CORIPREN ATOVER ZANIPRIL LERCAPREL 16/10/ /10/2021 TIOTROPIO BROMIDE SPIRIVA RESPIMAT 24/10/ /10/2021 EP TO2008B USE OF ROSUVASTATIN (ZD-4522) IN THE TREATMENT OF HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA ROSUVASTATIN CRESTOR 16/11/ /11/2021 EP EP MI2005B MI2006B PREVENTING TRANSPLANT REJECTION IN THE EYE PROCESS FOR THE SYNTHESIS OF AN LHRH PEPTIDE DESAMETASONE OZURDEX 28/11/ /11/2021 TRIPTORELINA DECAPEPTYL 19/12/ /12/2021 EP MI2011B BILAYER PHARMACEUTICAL TABLET COMPRISING TELMISARTAN AND HYDROCHLOROTHIAZIDE TELMISARTAN + IDROCLOROTIAZIDE MICARDISPLUS 16/01/ /01/2022 Elenco aggiornato al Pagina 11 di 15

12 IT EP EP EP EP EP TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTERING NON- STEROIDAL ANTIPHLOGISTIC AGENTS TO2008B CONTAINING CARBOXYL GROUPS, AND A METHOD FOR THE PRODUCTION OF THE SAME DERIVATI DI CARBOSTIRILE SOSTITUITO COME ANTAGONISTI TO2007B DEL SOTTOTIPO DI RECETTORE 5- HT1A PROCESS FOR THE PREPARATION OF MI2005B (E)-5-(2-BROMOVINYL)-2'- DEOXYURIDINE TO2007B TO2006B POLYMORPH OF ACID 4-[2-[4-[1-(2- ETHOXYETHYL)-1H-BENZIMIDAZOLE- 2-IL]-1-PIPERIDINYL]ETHYL]-ALPHA, ALPHA-DIMETHYL-BENZENEACETIC PARENTERAL FAT EMULSIONS COMPRISING EDETATE AS PRESERVATIVE FORMULAZIONI DI BISFOSFONATI A USO INIETTABILE IBUPROFENE IBUPAS 17/01/ /01/2022 ARIPIPRAZOLO ABILIFY 29/01/ /01/2022 BRIVUDINA BRIVIRAC ZECOVIR 21/02/ /02/2022 BILASTINA ROBILAS AYRINAL 19/04/ /04/2022 PROPOFOL DIPRIVAN 02/05/ /05/2022 CLODRONATO DISODICO CLODY 13/05/ /05/2022 EP RM2009B INFLUENZA VACCINE COMPOSITION INFLUENZA ANTIGEN FLUARIX 29/05/ /05/2022 EP EP RM2011B MI2007B HYPOTENSIVE LIPID (PROSTAGLANDIN) AND TIMOLOL COMPOSITIONS AND METHODS OF USING SAME A PROCESS FOR THE PREPARATION OF PIROXICAM: BETA-CYCLODEXTRIN INCLUSION COMPOUNDS BIMATOPROST / TIMOLOLO MALEATO PIROXICAM BETACICLODESTRINA GANFORT 30/05/ /05/2022 BREXIN CICLADOL CPR, BUSTINE, SUPP. 17/06/ /06/2022 EP MI2006B POWDER INHALER + O ALABASTER, FORMODUAL, FOSTER, INUVER: POLVERE PER INALAZIONE 31/07/ /07/2022 Elenco aggiornato al Pagina 12 di 15

13 EP EP EP TO2005B TO2008B TO2008B NEW PROCESS FOR THE PREPARATION OF THE TRIHYDRATE OF THE MAGNESIUM SALT OF S- OMEPRAZOLE ORAL DOSAGE FORMS FOR PROPIVERINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS WITH AN EXTENDED RELEASE OF THE ACTIVE INGREDIENT USE OF ANASTROZOLE FOR THE TREATMENT OF POST-MENOPAUSAL WOMEN HAVING EARLY BREAST CANCER EP TO2009B COMPOSITION FOR INHALATION EP EP TO2007B RM2011B PHARMACEUTICAL FORMULATION OF IRESSA COMPRISING A WATER- SOLUBLE CELLULOSE DERIVATIVE ADMINISTRATIONOF AGENTS FOR THE TREATMENTOF INFLAMMATION ESOMEPRAZOLE MG NEXIUM COMPRESSE 03/09/ /09/2022 PROPIVERINA CLORIDRATO MICTONORM 08/10/ /10/2022 ANASTROZOLE ARIMIDEX 06/12/ /12/2022 SYMBICORT SINESTIC 29/01/ /01/2023 GEFITINIB IRESSA 24/02/ /02/2023 NATALIZUMAB TYSABRY 25/02/ /02/2023 EP MI2006B PROCESS FOR PREPARATION OF A STERILE SUSPENSION OF CORTICOSTEROID PARTICLES FOR THE ADMINISTRATION BY INHALATION + SALBUTAMOLO BECLONEB CLENIL PRONTINAL CLENIL COMPOSITUM: SOSP PER NEBULIZZ 15/04/ /04/2023 EP EP EP EP TO2011B MI2011B TO2010B TO2009B PROCESS FOR PREPARING THE CALCIUM SALT OF ROSUVASTATIN HIGH DOSE IBANDRONATE FORMULATION MODIFIED-RELEASE TABLET OF BUPROPION HYDROCHLORIDE PROCESS FOR THE PREPARATION OF 4- (3'CHLORO-4'-FLUOROANILINO) -7- METHOXY-6- (3- MORPHOLINOPROPOXY) QUINAZOLINE ROSUVASTATIN CRESTOR 07/08/ /08/2023 ACIDO IBANDRONICO BONDRONAT 07/08/ /08/2023 BUPROPIONE CLORIDRATO WELLBUTRIN ELONTRIL 08/08/ /08/2023 GEFITINIB IRESSA 06/09/ /09/2023 Elenco aggiornato al Pagina 13 di 15

14 EP Elenco dei brevetti non coperti da certificato complementare di protezione TO2009B EP RM2012B DOSAGE FORM OF POWDER AGGLOMERATES HUMAN MONOCLONAL ANTIBODIES AGAINST CD20 MOMETASONE FUROATO ASMANEX 15/09/ /09/2023 OFATUMUMAB ARZERRA 17/10/ /10/2023 EP MI2012B BIODEGRADABLE OCULAR IMPLANT DESAMETASONE OZURDEX 07/01/ /01/2024 EP TO2006B INHALATION DEVICE EP EP EP EP EP EP EP EP TO2010B RM2011B TO2012B MI2009B TO2008B MI2011B MI2011B TO2012B IMPROVED PRODUCTION OF THE ROSUVASTATIN CALCIUM SALT PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR NEW CRYSTALLINE AND AMORPHOUS FORM OF A TRIAZOLO(4,5-D)PYRIMIDINE COMPOUND USE OF ANGIOTENSIN II RECEPTOR ANTAGONISTS, ESPECIALLY TELMISARTAN, IN ORDER TO INCREASE INSULIN SENSITIVITY X-RAY VISIBLE DRUG DELIVERY DEVICE METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS EXTENDED RELEASE TABLET FORMULATION CONTAINING PRAMIPEXOLE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF SYMBICORT SINESTIC 02/04/ /04/2024 ROSUVASTATIN CRESTOR 03/06/ /06/2024 SITAGLIPTIN JANUVIA 18/06/ /06/2024 TICAGRELOR BRILIQUE 30/06/ /06/2024 TELMISARTAN + AMLODIPINA ETONOGESTREL IMPLANT TWYNSTA 24/07/ /07/2024 IMPLANON NEXPLANON 14/03/ /03/ AMINOPYRIDINE FAMPYRA 11/04/ /04/2025 PRAMIPEXOLO MIRAPEXIN ER 25/07/ /07/2025 ESOMEPRAZOLE MG NEXIUM BUSTINE 20/12/ /12/2025 Elenco aggiornato al Pagina 14 di 15

15 EP EP Elenco dei brevetti non coperti da certificato complementare di protezione MI2012B TO2006B MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION SOSTANZA FARMACEUTICADI ARIPIPRAZOLO A BASSA IGROSCOPICITA' E PROCEDIMENTI PER LA SUA PREPARAZIONE POLISACCARIDE PNEUMOCOCCICO DEI SIEROTIPI 1,3,4,5,6A,6B,7F,9V,14,1 8C,19A, 19F,23F CONIUGATO E ADSORBITO PREVENAR 13 31/03/ /03/2026 ARIPIPRAZOLO ABILIFY 25/09/ /09/2022 EP MI2011B CAPECITABINE PEDIATRIC TABLETS CAPECITABINA XELODA 26/09/ /09/2027 EP TO2010B NOVEL COMPOSITION SYMBICORT 17/10/ /10/2028 Elenco aggiornato al Pagina 15 di 15