Step up the healing process BIOSTEP Matrix is a unique collagen dressing that allows you to overcome barriers to wound closure while maintaining an optimal moist wound environment. Collagen Matrix Dressings
Your next step toward wound closure The next generation collagen dressing that removes barriers to healing and facilitates wound closure Unique dual action 1 Targets and deactivates excess MMPs a, the enzymes that degrade proteins, to optimize wound closure Longer lasting 2 Six-day wear time for prolonged control of the wound environment Nearly double the wear time of other collagen dressings Easy to use Highly conformable dressing is easy to apply Moisture management 3 Maintains optimal moisture balance for wound closure a MMPs=matrix metalloproteases. b Only BIOSTEP Ag contains silver. Patient friendly Gelling action provides a cooling, soothing effect for enhanced patient comfort Antibacterial activities b of silver b Ag Minimizes infection recurrences when infection risk factors are present 2
Chronic wounds: a major problem with hidden costs Three to five million people in the US suffer with chronic wounds every year. 4 On average, the cost to close a chronic wound is around $40K per patient. 5 : an effective solution with targeted results When The wound is not closing at a fast enough rate or it is not progressing. Why Maintaining a balance between extracellular matrix proteins like collagen and the enzymes that break them down (MMPs) is essential for wound healing. When present in excess, MMPs break down collagen and new tissue at a faster rate than they are being produced. How The collagen in BIOSTEP attracts and binds MMPs while EDTA within the dressing deactivates them. Result A collagen dressing that provides sustained, targeted control of MMPs so that tissue regeneration can occur effectively. 3
Take two steps forward in wound healing Unique dual-action MMP targeting Step One Collagen attracts the MMPs away from the wound so that they break down the dressing and not the collagen within healing tissue. Step Two MMPs contain zinc ions that are necessary for their activity. EDTA binds the zinc ions to deactivate MMPs. Activated MMP EDTA-deactivated MMP EDTA in BIOSTEP boosts MMP deactivation, allowing new tissue formation and wound closure. 4
keeps MMP activity in check for up to six days 1 MMP Activity, RFU* 20 15 10 5 BIOSTEP Puracol Promogran 0 MMP-1 MMP-2 MMP-39 MMP Activity at six days Please note: The lower the number, the lower the MMP activity. BIOSTEP is more absorbent than other collagen dressings 3 Product Total Absorption Capacity (g/100 cm 2 ) Absorbency Under Compression (g/100 cm 2 ) BIOSTEP works well with a secondary dressing for optimal moisture management. BIOSTEP 20 13 Promogran Prisma 15 8 Promogran 8 4 BIOSTEP Ag minimizes infection recurrence when infection risk factors are present BIOSTEP Ag combines anti-mmp activity with the antibacterial activity of silver to maintain bacterial balance. *Samples are incubated with a relevant quantity of MMP (1, 2 or 9) and subsequent activity of MMP remaining is assessed. The result is quoted as RFU (relative fluorescent unit), compared with a control count at the start of the test. 5
A step above the competition No other collagen-based dressing offers the advantages of A comparison of collagen dressings Sacrificial substrate for MMPs BIOSTEP Puracol Promogran Sustained MMP deactivation (6 days) 1 Dual-action MMP targeting (collagen + EDTA) 1 Increased resiliency and strength 2,6 Enhanced patient comfort Optimal moisture management 3 Which wound types can benefit from BIOSTEP? BIOSTEP products are ideal for restarting the healing process in chronic, difficult-to-heal wounds, including: Other wound types include: Pressure ulcers Donor and graft sites Traumatic wounds Dehisced surgical wounds Diabetic foot ulcers Venous leg ulcers 6
Smith & Nephew products offer solutions for every step of Wound Bed Preparation T I M E Tissue nonviable or defi cient Infection or infl ammation Moisture imbalance Negative Pressure Wound Therapy (NPWT) Epidermal margin/ extracellular matrix ACTICOAT ALLEVYN SECURA VERSAJET ALLEVYN Ag SECURA IODOSORB An essential step in TIME (the E in TIME), BIOSTEP stimulates tissue regeneration to promote would closure. Speak to your Smith & Nephew representative today to arrange samples for evaluation. 7
Ordering information NEW Collagen Matrix Dressing Code Description Pcs/Pkg Pkgs/Unit 66800124 2" x 2" 10 5 66800125 4" x 4" 10 5 NEW Ag Collagen Matrix Dressing Code Description Pcs/Pkg Pkgs/Unit 66800126 2" x 2" 10 5 66800122 4" x 4" 10 5 Complementary Smith & Nephew products ACTICOAT ALLEVYN IODOSORB IODOFLEX PROFORE PROGUIDE OPSITE Negative Pressure Wound Therapy (NPWT) References 1. Data on file: Report #0706036. 2. Data on file: Report #0706033. 3. Data on file: Report #0705031. 4. Long-term Care Update: Issue 2, 2005. Oak Brook Terrace, IL. Joint Commission on Accreditation of Healthcare Organizations; 2005. 5. News release from the American Academy of Wound Management citing a report by Frost and Sullivan, United States Advanced Wound Management Product Markets, November 21, 2000. www.aawm.org/news_trend.html. 6. Data on file: Report #0705028. Wound Management Smith & Nephew, Inc. 970 11775 Lake Starkey Carillon RoadDrive Suite PO Box 1101970 St. Largo, Petersburg, Florida 33779 FL 33716 USA Customer Care Care Center Center www.smith-nephew.com 1 1 800-876-1261 www.biostepdressing.com T T 727-392-1261 www.globalwoundacademy.com F F 727-392-6914 2008 Smith & Nephew Trademark of Smith & Nephew. Certain marks Reg. US Pat. & TM Off. All Trademarks acknowledged. C0-0002-0608