Professor Ira Jacobson Official Opening ACADEMIC SPONSOR:

Professor Ira Jacobson Official Opening ACADEMIC SPONSOR:

Welcome to Frankfurt and The Viral Hepatitis Congress

Development of the Congress In 2010 we recognised a high volume of compounds for HCV that might reach the market by 2016 Developments are occurring at a rapid pace Based on the success of the HIV Congress (this November will be the 11th meeting since the congress was initiated in 1990) a forum for clinicians and investigators to assimilate complex information in a rapidly developing field with an increasing array of treatment options The Scientific Committee, co-chaired by myself and Professor Stefan Zeuzem under the auspices of Weill Cornell Medical College and Goethe Universität, has collaborated on ideas and topics to develop a relevant and exciting Scientific Programme

Joint Academic Sponsors

The Viral Hepatitis Congress Scientific Committee Scientific Committee Chairs Ira Jacobson Weill Cornell Medical College, New York, USA Stefan Zeuzem J.W. Goethe University, Frankfurt, Germany Scientific Committee Nezam Afdhal Harvard Medical School, Boston, USA Antonio Craxì University of Palermo, Palermo, Italy Geoffrey Dusheiko Royal Free Hospital and University College School of Medicine, London, UK Graham Foster Queen Mary, University of London, London, UK Patrick Marcellin University of Paris, Paris, France Hendrik Reesink Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Jürgen Rockstroh University of Bonn, Bonn, Germany

The Journey So Far

HCV Key Developments Interferon alfa Ribavirin Peginterferons Telaprevir & boceprevir Cure of HCV without IFN IL28B 1975 1986 1989 1993 1996 1997 1999 2000 2005 2008 2011 HCV identified Replicon developed Infectious virus 2a Description of non-a, non-b hepatitis Genome organization & processing determined Infectious clone developed Adaptive mutations identified Humanized mouse models established Adapted from Dr J Lemm

HBV Key Developments Adefovir Tenofovir Blood bank screening Genome sequenced Interferon alfa Lamivudine Entecavir, PEG- IFN2a Long term data on oral antivirals 1965 1970 1975 1980 1985 1990 1995 2000 2005 2010 2012 Discovery of Australia antigen (HBsAg) e antigen discovered HBV particle discovered by electron microscopy Plasma vaccine Recombinant vaccine Universal immunization of infants Telbivudine

The Viral Hepatitis Congress: Our Aim Continued innovation and progress results in a wealth of new information. We aim to: Provide you with a concise update on new advances in viral hepatitis To focus on practical guidance: what the new scientific developments mean for the present and the future clinical management of viral hepatitis

Meeting Format The Scientific Programme is built around a core format of plenary sessions, so you will never miss out on the latest information This afternoon there will be two Keynote Lectures on the hepatitis B and C viruses and over the next couple of days you will have the opportunity to listen to a world renowned faculty covering a wide range of topics Interaction is encouraged; tomorrow there are panel discussions and on Sunday we have a very busy agenda but there will still be opportunities to ask questions via cards and from the floor Please visit the scientific posters that will be displayed for the duration of the congress in the Casino building

Our Programme for Today 17.30 Official Opening I. Jacobson (USA) S. Zeuzem (Germany), 18.00 Key Note Lecture: Hepatitis C Virus R. Bartenschlager (Germany) 18.30 Key Note Lecture: Hepatitis B Virus B. McMahon (USA)

We Welcome Your Participation Question cards and standing microphones are provided Please fill in the question cards during the presentation and pass to a staff member If you wish to ask a question or raise a point during the Q&A sessions, please make your way to one of the standing microphones

Thank you to our sponsors

And finally Please turn off your mobile phone This meeting has been granted 13 CME credits by the European Accreditation Council for Continuing Medical Education (EACCME). To obtain your CME credits, you must sign the register on the Congress General Information Desk on a daily basis More information on CME credits can be found in your Final Programme Booklet