MILESTONE LOGOS J. The right tool for the lean lab. The first personal hybrid tissue processor Quality. Speed. Flexibility. Automation.

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MILESTONE H E L P I N G P A T I E N T S LOGOS J The right tool for the lean lab The first personal hybrid tissue processor Quality. Speed. Flexibility. Automation.

The processor that did not exist. But was needed. Milestone has matched the unarticulated needs of users with technological possibilities that open new doors. LOGOS J as... The LOGOS J is the result of a philosophy that sets a new standard in the field of tissue processing.

... a dedicated rapid tissue processor for stat, urgent or transplant biopsies, for results within 50-60 minutes.... a rapid, flexible, tissue processor for biopsies (up to 3mm) to level-out the work load in the lab.... an optimized conventional resistance heated processor for HER-2, ER, PgR according to ASCO and CAP guidelines.... a dedicated, optimized rapid tissue processor for specific specimens: prostate, skin, gastric,...... your application?... a fully automated bone marrow processor for turn around time in less than 24 hours.

The challenge: improving the workflow of the laboratory. In today s histology labs, the workload consists approximately of 35-50% small biopsies (below 3 mm) and 40-50% surgical specimens. Transplant, stat and urgent biopsies that require a rapid turnaround time are a minority of the total workload. This small number of biopsies interferes with the routine workflow of the laboratory. Large capacity conventional tissue processors do not fulfill the requirements for the speed and flexibility needed to effectively improve the workflow of a laboratory or address these specific workflow streams. Unmatched quality LOGOS J processes biopsies with specific optimized protocols to consistently assure the highest standard of quality. Colonic biopsy, microwave processed H&E (x 400) Bowel biopsy, microwave processed. Alcian blue microwave staining (x 400) Breast cells HER2 amplification detection by IHC. Hematoxylin counterstain (x 400) Breast cells HER2 amplification detection by FISH processed by microwaves (x 800). Unmatched processing times Faster than conventional processing Specimen thickness Transplant (less than 1mm) 1 mm (i.e. GI/Endoscopic byopsies) Rapid protocols. Fully automated Full batch processed in 36 minutes (including fixation) Full batch processed in 1 h 16 minutes (including fixation) Improved workflow with sequential processing in continuous batch mode Batch loading every 21 minutes Batch loading every 51 minutes 3 mm Full batch processed in 3 h 28 minutes (including fixation) Batch loading every 2 hours 13 minutes Note: The above timing are referred to ethanol/isopropanol protocols, excluding reagent movement. Unmatched processing flexibility From 1 up to 48 cassettes The LOGOS J rack consists of 48 cassettes to allow the flexibility to fit any workload requirements. (Optional: 2 segments of 21 cassettes each)

LOGOS J. The right tool for the lean lab. Implementation of the lean lab requires optimized dedicated instrumentation. The LOGOS J fulfills this requirement and addresses the unmet need for a benchtop, compact, flexible load, rapid tissue processor. This new tool incorporates an innovative solution to solve workflow problems in histology laboratories. Day Operation (1). Urgent specimens. As a fully automated, single, rapid hybrid tissue processor Processing Wax During the day the histotech will start dedicated single batch runs with short cleaning cycles. LOGOS J will run urgent biopsies with hybrid microwave technology as a fully automated unit. Molten wax will be transferred automatically to and from the processing for impregnation. Day Operation (2). Higher throughput. As a sequential, dual, simultaneous batch hybrid tissue processor Processing Wax 1 The first rack is processed in the fixation/dehydration/ clearing processing 2 At the end of the cycle, the rack is manually transferred to the wax 3 A new rack is placed in the processing. The two racks are simultaneously processed. Night Operation. Fully automated, bone marrow processor for a diagnosis in less than 24 hours Processing Wax During the night, or if required during the day, LOGOS J will process bone marrow specimens through the fixation, decalcification, dehydration clearing and impregnation steps in a fully automated mode. The specimens will be ready for cutting, embedding and staining to allow rapid diagnosis in less than 24-hour.

LOGOS J. Software like never before. We could not make it more intuitive. 1 Enter the appropriate user level. The administrator can modify programs or store new ones. The operator can recall and run existing processing protocols. Intuitive touch display. 2 Icon-driven. User friendly. 3 Administrator can easily setup a new protocol by selecting through the multiple choices available for each step. 4 The complete summary of the new protocol is displayed for approval or modification before starting the process. 5 An events log lists all activities carried out with the unit for documentation, service and quality assurance purposes.

LOGOS J. Green, safe and economical. Packed with the latest technology for an improved work environment. Up to 10 quick disconnect 2 l reagent tanks Heated, PTFE coated, internal surface to avoid condensation of reagents for consistent processing. Enhanced operator safety by elimination of vapors Touch-screen, icon-driven control terminal Microwave Wax Easy, safe transfer of exhausted wax through heated PTFE connector Open system. No proprietary reagents commitments. Use of histology grade wax. Milestone world market leadership Largest installed base of microwave tissue processors Over 1,600 units in operation worldwide The de facto standard in rapid processing Lowest cost of ownership The highest quality of application and service support

LOGOS J. Fully automated bone marrow processing for a diagnosis in less than 24-hours. Hours, not days! For the fist time fully automated fixation (formalin), decalcification (formic acid, EDTA), dehydration, clearing and impregnation of bone marrow samples can be carried out in less than 24 hours. Total processing time (fixation to impregnation) for bone marrow specimens of 1.8 mm diameter (11 gauge) Bone marrow, EDTA, H&E x 100 Decalcifier Temperature Time Formic acid 10% 37 C 4h 11 Formic acid 10% 50 C 3h 16 EDTA 10% 37 C 20h 41 EDTA 10% 50 C 5h 46 Note: The above timing are referred to ethanol/isopropanol protocols, excluding reagent movement. MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5-24010 Sorisole (BG) - Italy Tel: +39 035 4128264 - Fax: +39 035 575498 www.milestonemedsrl.com - email: medical@milestonesrl.com UNI EN ISO 9001: 2008 / UNI EN ISO 13485:2012 CERTIFIED In your country: H E L P I N G P A T I E N T S MILESTONE MEDICAL TECHNOLOGIES, INC. 6475 Technology Avenue, Suite F, Kalamazoo, MI 49009 - USA Tel: 269-488-4950 - Toll-free: 866-995-5300 - Fax: 269-488-4949 www.milestonemed.com - email: info@milestonemed.com CAT330-002