The Teen Brain What s Going on in There? Sion Kim Harris, PhD Boston Children s Hospital Harvard Medical School
Center for Adolescent Substance Abuse Research www.ceasar-boston.org
Leading Causes of Mortality, Ages 10-24, United States, 2010 Motor Vehicle Crashes 35% Other Unintentional Injuries (e.g., Poisoning) 14% Homicides 17% Suicides 11% TOTAL 72% Source: US DHHS, Health Resources and Services Administration, Maternal and Child Health Bureau. Child Health USA 2010. Rockville, Maryland: U.S. Department of Health and Human Services, 2010.
The Age of the Brain Any Questions? 7
The human brain weighs about the same as a. A. Donut B. Six-pack of soda C. Chihuahua
Until recently, brain development was thought to be complete by about age 12 Teen Brain Adult Brain 10
Brain Weight by Age Males Females Newborn Age Source: Dekaban, A.S. and Sadowsky, D. Annals of Neurology, 4:345-356, 1978 11
What we now know Adolescence is a critical period in brain development. The brain is still developing until about age 24!!! Slide courtesy of Ken Winters, PhD. 12
What is a critical period in brain development? 13
Drs. David Hubel and Torsten Wiesel Source: Hubel, D. Eye, Brain, and Vision. http://hubel.med.harvard.edu/index.html
Fixing cataracts in children didn t restore sight Source: UCSF.edu
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Critical Period Definition: A window in brain development when a part of the brain develops rapidly highly sensitive to being shaped by experience and environmental exposures
Construction Ahead Around age 12, brain cells start to undergo pruning process guided by use it or lose it Slide courtesy of Ken Winters, PhD.
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Construction Ahead At the same time, myelin starts to cover neurons Helps neurons communicate 100 times faster Slide courtesy of Ken Winters, PhD. 23
The Brain s Information Superhighway: Myelinated axons = White Matter Tracts Source: Gordon J. Harris, PhD. 24
Construction Ahead Result when pruning and myelination are complete: faster, but fewer, connections in the brain critical period closes Slide courtesy of Ken Winters, PhD. 25
Pruning and myelination from age 5 to 20 Neuropsychopharmacology Reviews advance online publication 22 October 2014. doi:10.1038/npp.2014.236
Copyright 2013 John R Knight MD, Center for Adolescent Substance Abuse Research (CeASAR), Boston Children s Hospital. All rights reserved. Brain Development is shaped by genes & experiences at critical points in time 27
Key Point: Teen brain highly neuroplastic Adolescence is an important window of opportunity and sensitivity for the brain How the brain is used during adolescence, and what it is exposed to, will have lifelong effects
This is Your (Developing) Brain on Drugs 2015 29
Age at First Drink and Risk of Alcohol Addiction % with Alcohol Disorder Age at First Drink Source: Hingson RW, Heeren T, Winter MR. Age at drinking onset and alcohol dependence. Arch Pediatr Adolesc Med. 2006;160:739-746.
Age at First Use and Risk of Marijuana Addiction Source: Substance Abuse and Mental Health Services Administration. (2010). Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4586Findings). Rockville, MD.
Why are adolescents more vulnerable to developing addiction?
Teen brains are affected by alcohol and drugs differently from adult brains Let s look at the evidence regarding alcohol Slide courtesy of Ken Winters, PhD. 33
Animal Studies Compared to adult rats, adolescent rats found to be less sensitive to alcohol with regards to its Sedative effects Motor impairment Slide courtesy of Ken Winters, PhD. Sources: White AM, Truesdale M, Bae J, et al. Differential effects of alcohol on motor coordination in adolescent and adult rats. Pharmacology Biochemistry and Behavior. 2002;73:673-677. Silveri MM, Spear LP. Decreased sensitivity to the hypnotic effects 34 of ethanol early in ontogeny. Alcoholism: Clinical and Experimental Research. 1998;22:670-676.
Amount of Alcohol Needed for Sedation by Rat s Age Alcohol-induced sedation Time to Turning Over by Age Slide courtesy of Marisa Silveri, PhD. Source: Silveri M & Spear L, Alcoholism: Clinical and Experimental Research. 1998;22:670-676
Motor Performance: The Water Maze Test End 36
The Water Maze Test End 37
Results of Water Maze Test Swimming Speed (Motor strength and control) Finding Platform (Learning, problemsolving) Adult Adolescent Adult Adolescent Alcohol vs. Saline SAME White, A. M., Truesdale, M., Bae, J., Ahmad, S., Wilson, W. A., Best, P., et al. (2002). Differential effects of alcohol on motor coordination in adolescent and adult rats. Pharmacology Biochemistry and Behavior, 73, 673-677.
Drunk Adult Drunk Adolescent Slide courtesy of John R Knight, MD.
Wide-Awake Drunk Teens Source: Boston Globe August 21, 2003 Slide courtesy of John R Knight, MD.
Teen brains react to rewarding things Brain areas with greatest changes during adolescence Front differently from adults Back Source: Sowell ER, Thompson PM, Holmes CJ, Jernigan TL, Toga AW. In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience. 1999;2:859 861. Used with permission.
The Reward Pathway Source: NIDA Ventral-Tegmental Area
Comparing Reward Pathway Function across Age Groups Study participants in MRI scanner asked to play a money game with small, medium, or large rewards Source: Galvan A et al. Journal of Neuroscience, 2006,26(25):6885 6892
Studying the Living Brain: Functional Magnetic Resonance Imaging (fmri) Movies of brain activity Measures blood flow to brain areas that are active Slide courtesy of Susan Tapert, PhD. 44
BRAIN RESPONSE TO SMALL REWARD Children ages 7-11 Teens ages 13-17 Adults ages 23-29 Source: Galvan A, Hare AT, Parra, CE, Penn J, Voss H, Glover G, Casey BJ, Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents. Journal of Neuroscience, 2006,26(25):6885 6892
BRAIN RESPONSE TO LARGE REWARD Children ages 7-11 Teens ages 13-17 Adults ages 23-29 Source: Galvan A, Hare AT, Parra, CE, Penn J, Voss H, Glover G, Casey BJ, Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents. Journal of Neuroscience, 2006,26(25):6885 6892
Adolescent brains have a greater response to HIGHLY STIMULATING activities, like 47
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Source: NIDA marijuana
Some parts of the brain develop slower Brain areas with greatest changes during adolescence Front than others Back Source: Sowell ER, Thompson PM, Holmes CJ, Jernigan TL, Toga AW. In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience. 1999;2:859 861. Used with permission.
Pre-Frontal Cortex Functions Our internal CEO : critical for executive functions, such as Impulse control Decision-making Organizing and planning Abstract thought, rational thinking Attention, focus Working memory
Pruning and myelination from age 5 to 20 Neuropsychopharmacology Reviews advance online publication 22 October 2014. doi:10.1038/npp.2014.236
Braking and Accelerating in the Adolescent Brain The gas pedal develops faster than the braking system Adult Source: Casey BJ, et al., Development Reviews. 2008; 28(1): 62-77 Source: Casey BJ, Getz S, Galvan A. The adolescent brain. Dev Rev. 2008;28(1):62-77. Used with permission.
Brain Connectivity with Maturation Front Source: Dosenbach et al. Science. 2010;329:1358-1361. 56
The Developing Brain: Implications for Teens Less ability to inhibit impulses and strong emotions Higher physical tolerance and stronger reward response to addictive substances More vulnerable to developing a problem with alcohol and drugs Slide courtesy of Ken Winters, PhD. 57
International Comparison of Binge Drinking Rates*, 2014 (*6+ drinks in a row) Minimum legal drinking age: 21 18 16 for beer
International Comparison of Binge Drinking Rates*, 2014 (*6+ drinks in a row)
Alcohol and Marijuana Effects on Teen Memory and Cognition 60
Hippocampus: The Key to the SAT s 61
The Human Hippocampus and Alcohol 10-35% smaller among heavydrinking teens hippocampus Slide courtesy of Susan Tapert, PhD. Nagel BJ, Schweinsburg AD, Phan V, Tapert SF. Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity. Psychiatry Research Neuroimaging. 2005;139:181-190.
How does this affect brain function? Functional magnetic resonance imaging (fmri) Non-invasive Movies of brain activity Slide courtesy of Susan Tapert, PhD. 63
Teen Drinking & Brain Activity in Memory Task Non-Drinkers Heavy Drinkers Age 16 Activation Age 20 De-activation Slide courtesy of Susan Tapert, PhD. Tapert SF, Brown GG, Kindermann SS, Cheung EH, Frank LR, Brown SA. fmri measurement of brain dysfunction in alcohol-dependent young women. Alcoholism: Clinical and Experimental Research. 2001;25(2):236-245. 64
Marijuana effects on memory and cognitive function
THC and Memory THC suppresses activity of hippocampal neurons below the level needed to trigger memory formation With chronic THC exposure, neuron connections involved in memory are gradually lost due to continual suppression Source: Iversen L. How cannabis works in the brain. In Marijuana and Madness. Ed. Castle & Murray, 2004. Oxford University Press.
The Dunedin Study (New Zealand) (N=1,037) 13 yrs (Pre-initiation) 18 yrs 21 yrs 32 yrs 38 yrs 1 2 3 4 5 Assessment ages Source: Meier et al. PNAS, 2012
Change in IQ from 13 to 38 yrs old 13 yrs old 38 yrs old 99.8 100.6 Average IQ Never used marijuana
Change in IQ from 13 to 38 yrs old Average IQ Never used marijuana Used marijuana 3+ years
IQ Change by Age when Weekly Use Began, Among Those No Longer Using at age 38 Source: Meier et al. PNAS, 2012 Before 18 18+ Age weekly use began
STUDIES Cognitive Effects Brain Structure Brain Function Meier et al., 2012 Pope et al., 2003 Ehrenreich et al., 1999 IQ IQ attention Huestegge et al., 2002 Fontes et al., 2011 Solowij et al., 2012 visual search task executive functioning executive functioning Churchwell et al., 2010 prefrontal cortex volume Gruber et al., 2011 impulsivity white matter integrity in prefrontal cortex Lopez-Larson et al., 2011 Wilson et al., 2000 Becker et al., 2010a Gruber et al., 2012 Jager et al., 2010 prefrontal cortex thickness total gray matter, prefrontal cortex activity during working memory task anterior cingulate activity during inhibition task prefrontal cortex activity during in working memory
Marijuana and Mental Illness
Marijuana and Mental Disorders Times Used Illness Increase in Risk 1 Schizophrenia 1.2X 50 + Schizophrenia 6.7X Weekly Daily Depression & Anxiety Depression & Anxiety 2X 5X Lynskey et al., Arch Gen Psychiatry, 2004;61(10):1076-1032 Patton et al., British Medical Journal, 2002;325:1195-1198 Zammit S et al., BMJ, 2002;325:1199. Degenhardt et al., Addiction. 2012:108:126-133
Genetic Risk 7 times higher risk for psychosis with C/C variant Source: Di Forti et al. Biol Psychiatry. 2012.
Avg. % THC Content among Confiscated Cannabis Products in U.S. (1995-2014) ~12% ~4% *Source: ElSohly et al., Biological Psychiatry, 2016. *38,681 samples
As THC content increases, we see more adverse effects: Paranoia Anxiety and panic Hallucinations Erratic mood swings Aggressive behavior Source: National Drug Abuse Warning Network, 2011
Teen Brain Plasticity It s a double-edged sword Vulnerability Opportunity
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Advise DELAYING use until age 21+