OUR JOURNEY THROUGH THE YEARS



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The King Faisal Specialist Hospital and Research Centre Experience in Hematology, Oncology and Bone Marrow Transplantation OUR JOURNEY THROUGH THE YEARS REGGIE BELKHEDIM

A Brief Overview: King Faisal Specialist Hospital and Research Centre King Faisal Specialist Hospital and Research Centre (KFSHRC) is a tertiary hospital located in Riyadh with a facility in Jeddah, Saudi Arabia. KFSHRC-Riyadh was opened by the late King Khalid in 1975. It has over 11,000 employees of more than 63 nationalities and counting with its new expansion programs.

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE Our Journey through the Years YEAR LANDMARKS and ACHIEVEMENTS 1984 Implementation Of Allogeneic Program 1986 Implementation Of Autologous Program Late 80 s EBMT and CIBMTR memberships 1993 Autonomy of operations of Pediatric and Adult BMT Programs 1994 Adult Medical Oncology began Peripheral Stem Cell Program for Breast Cancer patients 1995 Implementation of the Lymphoma programs 1996 Implementation of Allogeneic Peripheral Stem Cell Transplant

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE Our Journey through the Years YEAR LANDMARKS and ACHIEVEMENTS 1998 Initiation of: Donor Lymphocyte Infusion Program Stem Cell Allo/Auto-Mobilization in Outpatient setting Post BMT Follow/up Program 1999 Implementation of: High Dose Therapy and PBSCT Rescuefor Multiple Myeloma 2000 Implementation of: Non-MyeloablativeRegimen (done in the Outpatient setting)

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE Our Journey through the Years YEAR LANDMARKS and ACHIEVEMENTS 2003 Implementation of: Donor Bone Marrow harvest in Outpatient setting Unrelated SCT Program (MUD & Umbilical Cord) NMDP Training and Certification 2004 First MUD in Saudi Arabia from donor from USA 2005 Implementation of: Extracorporeal Phototherapy Treatment patients for GVHD patients Infertility Clinic for Post-transplant patients HaploidenticalTransplantation was initiated for the Pediatric program

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE Our Journey through the Years YEAR LANDMARKS and ACHIEVEMENTS 2006 First stem cell apheresis were conducted in the Outpatient setting for our donors 2007 First BMT Congress hosted by KFSHRC-EMBMT EMBMT Nursing guidelines presented to EBMT 2008 JACIE application Implementation of the 1 st Quality Management Committee for SCT JACIE Inspection and Report (Nov 2008) 2009 Implemented JACIE recommendations

HEMATOLOGY, ONCOLOGY AND BMT: KFSHRC EXPERIENCE Our Journey through the Years YEAR LANDMARKS and ACHIEVEMENTS 2010 JACIE APPROVAL AND ACCREDITATION BMT Donor clinic added to BMT office and clinics EMBMT Nursing group s implementation of Constitution and Guidelines as well as Committee s operations 2013 Establishment of: Haploidentical Transplantation for Adult programs Stem Cell Donor Registry 2014 Implementation of a section: Non-Neoplastic Hematologic Disorder Program

Northern Provinces Eastern Provinces RIYADH Western Provinces Southern Provinces

TOTAL ALLO, AUTO, DLI & CB TRANSPLANTS (Adult and Pediatric) 1984-2013 BACK TO PREVIOUS

King Faisal Specialist Hospital & Research Center ALLO Transplants 1984-2013 140 120 100 80 60 40 20 0 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 10 11 12 13 ADULT 8 15 21 18 25 18 29 24 35 37 31 44 47 66 69 45 59 50 63 70 87 72 73 41 82 82 112 72 87 105 PEDIATRIC 7 7 9 15 23 19 18 24 16 15 30 33 43 37 59 71 59 55 72 73 74 92 100 65 105 110 119 125 133 123 BACK TO PREVIOUS

King Faisal Specialist Hospital & Research Center Total ALLO, AUTO, DLI & CB TRANSPLANTS Adults & Pediatrics (1984 2013) 3500 3000 2500 2000 1500 1000 500 0 ALLO AUTO DLI CB MUD NO. 3354 1020 132 280 7 BACK TO PREVIOUS

King Faisal Specialist Hospital & Research Center AUTO Transplants 1984-2013 80 70 60 50 40 30 20 10 0 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 10 11 12 13 ADULT 0 1 2 10 7 14 10 7 13 21 14 4 14 16 18 23 21 27 43 40 47 50 72 47 65 64 60 61 58 48 PEDIATRIC 0 0 0 15 0 1 1 1 0 0 0 3 2 3 2 3 1 11 3 2 7 9 14 4 13 11 21 19 14 11 BACK TO PREVIOUS

King Faisal Specialist Hospital & Research Center DLI & CB Adult & Pediatrics 1995-2013 BACK TO PREVIOUS

Patient Care Performs all types of transplant that exist anywhere in the world at the highest standards including: 1. Allogeneic Related Transplantation 2. Allogeneic Unrelated Transplantation 3. Allogeneic Mismatched Transplantation 4. Autologous Transplantation 5. Cord Blood Transplantation 6. Cellular/Immunotherapy for treatment of relapse Over the years the transplantation age limit had been advanced to 70 years for Auto and 65 years for Allo transplantation Institutional Cord Blood Bank

Patient Care Consistently one of the world s largest 5% centers for performance of Bone Marrow and Stem Cell Transplantation The world s largest Transplantation Program for several disorders including but not limited to congenital and acquired bone marrow failure and other disorders

KFSRHRC COLLABORATION WITH INTERNATIONAL BMT SOCIETIES/ORGANIZATIONS

Accreditations and Recognition of KFSH Bone Marrow and HSCT Program ORGANIZATION/PROVIDER Canadian Bone Marrow Transplantation Group (CBMTG) REFERENCE # / DESCRIPTION Largest Accruing Center Center for International Blood and Marrow Transplant Research (CIBMTR) 10112 Committee Chairmanship (2) Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) KFSH&RC is the Head Office European Group for Blood & Marrow Transplantation (EBMT) 397:1 Committee Membership Nursing Committee Chairmanship Joint Accreditation Commission ISCT EBMT (JACIE) 1 st Center accredited Center outside Europe Valid until Jan 2014 National Marrow Donor Program Transplant Center (NMDP) TC # 495 Full Affiliation (Patient Care and Research) NCI Institution # 95002 Worldwide Network for Blood and Marrow Transplantation (WBMT) Board of Directors Members May do 2015 annual meeting in KSA Standing Committee Members Institutional Cord Blood Bank EMBMT Matched Unrelated Donor Registry Journal Hematology/Oncology and Stem Cell Therapy Provides Cord Blood Units, Local and Regional Underway, Issues with MOH, Council of Health Cs KFSH&RC is the Home Office

Training Providing training at every level The primary hospital for transplantation training for the Saudi fellowship in Hematology Established one (1) year designated Fellowship in HSCT Nursing training program for: BMT Nurses (under KFSHRC Nursing development) BMT Coordinators (under EMBMT) Stem Cell Quality manager (under EMBMT) Data Management course (under EMBMT)

EASTERN MEDITERRANEAN BLOOD AND MARROW TRANSPLANTATION GROUP Is an active group member of the European Society for Blood and Marrow Transplantation (EBMT) Established in 2008; headquarters based at KFSHRC-Riyadh, Saudi Arabia Has memberships from 13 countries from the WHO designated Eastern Mediterranean area with the goal of sharing experience, initiation of cooperative trials and establish common strategy to achieve optimization in the field of HSCT.

FUTURE EXPANSIONS AT KFSHRC RIYADH: Our Journey Continues

Thank you Danke Grazie Merci The KING ABDULLAH CENTER FOR ONCOLOGY AND LIVER DISEASE