Research Annual Report 2010

Research Annual Report 2010 Netherlands Institute for Health Sciences (NIHES) Assessment, Treatment and Translational Research in Recontructive Surgery Epidemiology of diseases Basic epidemiologic research Clinical epidemiology Biostatistics Effects of screening and clinical interventions on population health Determinants and primary prevention Clinical research in general practice. Implementation of diagnostic and interventional imaging technology Assessment of diagnostic and interventional imaging technology Development of acquisition and processing techniques for diagnostic imaging Structuring of medical knowledge Structuring of medical data 11771, B&T Ontwerp en advies (http://www.b-en-t.nl)

Research Annual Report 2010 Netherlands Institute for Health Sciences (NIHES) Assessment, aetiology and course of child and adolescent psychiatry Adaptation of (future) patients to disease and treatment in order to improve counselling and guidance Health care management (theme 3) Quality and efficiency in health care (theme 2) Competition and regulation in health care (theme 1) 11771, B&T Ontwerp en advies (http://www.b-en-t.nl)

EMC NIHES-01-50-01-A - Assessment, Treatment and Translational Research in Recontructive Surgery Programme in brief design The program `Assessment, Treatment and Translational Research in Reconstructive Surgery relates to research questions derived from three main patient groups: upper extremity disorders, craniofacial disorders and patients requiring reconstructions after oncological resection. Furthermore wound healing plays an important role in reconstructive surgery. Within these three patient groups, we share the same three research topics, which are often interrelated. 1) Development and evaluation of innovative clinical interventions, either in randomized or cohort studies. 2) Development and application of new assessment tools, such as new imaging techniques and measurement tools to be used for both diagnosis and outcome assessment. 3) Development and evaluation of innovative experimental interventions with a close relation to the clinic. Most clinical and translational research is multidisciplinary, resulting in collaboration with a large number of clinical and preclinical departments. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot oral and maxillofacial surgery 0,2 0 0 0 0,2 pediatric psychiatry 0,1 0 0 0 0,1 plastic and reconstructive surgery 3,9 0 0 4,65 8,55 rehabilitation 0 0 0 0,5 0,5 Total 4,2 0 0 5,15 9,35 6 1 0 7 49 4 1 61 Thesis Bannink, N. (2010, september 01). Obstructive sleep apnea in children with syndromic craniosynostosis. EUR (185 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof. Dr. S.E.R. Hovius, Dr. I.M.J. Mathijssen & Dr. K.F.M. Joosten. Bruggeman, J.P. (2010, oktober 22). Biodegradable polyol-based polymers. A polymer platform for biomedical applications. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Molenaar, H.M. (2010, juni 10). Measuring hand strength in children. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. H.J. Stam. Rath, S. (2010, juni 04). Early active mobilization of tendon transfers. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof. Dr. H.J. Stam. Stokvis, A. (2010, september 24). Surgical management of painful neuromas. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Ultee, J. (2010, juni 15). Outcome following peripheral nerve injury of the forearm. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius. Versnel, S.L.. Let s face it! Causes, treatment and consequences of rare facial clefts. EUR. Prom./coprom.: Prof. Dr. S.E.R. Hovius & Prof.Dr. J. Passchier. Artikel/Letter to the editor Ananta, M & Coert, J.H. (2010). Prevention of wound infection after release of Apert acrosyndactyly. Plastic and Reconstructive Surgery, 126(1), 42e-43e. Bannink, N., Mathijssen, I.M.J. & Joosten, K.F.M. (2010). Can parents predict obstructive sleep apnea in children with syndromic or complex craniosynostosis? International Journal of Oral and Maxillofacial Surgery, 39, 421-423. Bannink, N., Maliepaard, M., Raat, H., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Health-related quality of life in children and adolescent with syndromic craniosynostosis. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63, 1972-1981. Bannink, N., Nout, E., Wolvius, E.B., Hoeve, L.J., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Obstructive sleep apnea in children with syndromic craniosynostosis: long-term respiratory outcome of midface advancement. International Journal of Oral and Maxillofacial Surgery, 39(2), 115-121. Bannink, N., Mathijssen, I.M.J. & Joosten, K.F.M. (2010). Use of ambulatory polysomnography in children with syndromic craniosynostisis. Journal of Craniofacial Surgery, 21(5), 1365-1368. Boender, Z.J., Ultee, J. & Hovius, S.E.R. (2010). Cognitive capacity: No association with recovery of sensibility by Semmes Weinstein test score after peripheral nerve injury of the forearm. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(2), 354-359. Bruggeman, J.P., Bettinger, CJ & Langer, R (2010). Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility. Journal of Biomedical Materials Research Part A, 95A(1), 92-104. Coert, J.H. (2010). Pathophysiology of nerve regeneration and nerve reconstruction in burned patients. Burns, 36(5), 593-598. 223

Colaris, J.W., Linden, M.W. van der, Selles, R.W., Coene, N, Allema, J.H. & Verhaar, J.A.N. (2010). Pronation and supination after forearm fractures in children: Reliability of visual estimation and conventional goniometry measurement. Injury-International Journal of the Care of the Injured, 41(6), 643-646. Damen, T.H.C., Timman, R., Kunst, EH, Gopie, JP, Bresser, P.J.C., Seynaeve, C., Menke - Pluijmers, M.B.E., Mureau, M.A.M., Hofer, S.O.P. & Tibben, A. (2010). High satisfaction rates in women after DIEP flap breast reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(1), 93-100. Driel, A.A. van, Mureau, M.A.M., Goldstein, DP, Gilbert, RW, Irish, J.C., Gullane, P.J., Neligan, P.C. & Hofer, S.O.P. (2010). Aesthetic and Oncologic Outcome after Microsurgical Reconstruction of Complex Scalp and Forehead Defects after Malignant Tumor Resection: An Algorithm for Treatment. Plastic and Reconstructive Surgery, 126(2), 460-470. Florisson, J.M.G., Veelen, M.L.C. van, Bannink, N., Adrichem, L.N.A. van, Meulen, J.J.N.M. van der, Bartels, M.C. & Mathijssen, I.M.J. (2010). Papilledema in Isolated Single-Suture Craniosynostosis: Prevalence and Predictive Factors. Journal of Craniofacial Surgery, 21(1), 20-24. Gooskens, S.L.M., Oranje, A.P., Adrichem, L.N.A. van, Waard- van der Spek, F.B. de, Hollander, J.C. den, Ven, C.P. van de & Heuvel-Eibrink, M.M. van den (2010). Imatinib mesylate for children with dermatofibrosarcoma protuberans (DFSP). Pediatric Blood & Cancer, 55, 369-373. Haeseker, G.A., Mureau, M.A.M. & Faber, F.W.M. (2010). Lateral Column Lengthening for Acquired Adult Flatfoot Deformity Caused by Posterior Tibial Tendon Dysfunction Stage II: A Retrospective Comparison of Calcaneus Osteotomy with Calcaneocuboid Distraction Arthrodesis. Journal of Foot & Ankle Surgery, 49(4), 380-384. Hofer, S.O.P. & Mureau, M.A.M. (2010). Pedicled Perforator Flaps in the Head and Neck. Clinics in Plastic Surgery, 37(4), 627- +. Hossaini, S.M., Duraku, L., Sarac, C, Jongen, J.L.M. & Holstege, J.C. (2010). Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. Pain, 151(2), 356-365. Huisstede, B.M., Randsdorp, M.S., Coert, J.H., Glerum, S., Middelkoop, M. van & Koes, B.W. (2010). Carpal Tunnel Syndrome. Part II: Effectiveness of Surgical Treatments-A Systematic Review. Archives of Physical Medicine and Rehabilitation, 91(7), 1005-1024. Jong, T. de, Bannink, N., Bredero-Boelhouwer, H.H., Veelen, M.L.C. van, Bartels, M.C., Hoeve, L.J., Hoogeboom, A.J.M., Wolvius, E.B., Lequin, M.H., Meulen, J.J.N.M. van der, Adrichem, L.N.A. van, Vaandrager, J.M., Ongkosuwito, E.M., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(10), 1635-1641. Korstanje, J.H., Selles, R.W., Stam, H.J., Hovius, S.E.R. & Bosch, J.G. (2010). Development and validation of ultrasound speckle tracking to quantify tendon displacement. Journal of Biomechanics, 43(7), 1373-1379. Korstanje, J.H., Schreuders, A.R., Sijde, K. van der, Hovius, S.E.R., Bosch, J.G. & Selles, R.W. (2010). Ultrasonographic Assessment of Long Finger Tendon Excursion in Zone V During Passive and Active Tendon Gliding Exercises. Journal of Hand Surgery-American Volume, 35A(4), 559-565. Kusters, F.J.G., Walbeehm, E.T. & Niehof, S.P. (2010). Neural influence on cold induced vasodilatation using a new set-up for bilateral measurement in the rat hind limb. Journal of Neuroscience Methods, 193(1), 100-105. Mathijssen, I.M.J. & Meulen, J.C. van der (2010). Guidelines for reconstruction of the eyelids and canthal regions. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(9), 1420-1433. Molenaar, H.M., Selles, R.W., Zuidam, J.M., Willemsen, S.P., Stam, H.J. & Hovius, S.E.R. (2010). Growth Diagrams for Grip Strength in Children. Clinical Orthopaedics & Related Research, 468(1), 217-223. Molenaar, H.M., Kraker, M. de, Zuidam, J.M., Hovius, S.E.R., Stam, H.J. & Selles, R.W. (2010). Visual Feedback and Weight Reduction of a Grip Strength Dynamometer Do Not Increase Reliability in Healthy Children. Journal of Hand Therapy, 23(3), 272-279. Moolenburgh, S.E., Mac Lennan, L.M., Levendag, P.C., Munte, K., Scholtemeijer, M., Hofer, S.O.P. & Mureau, M.A.M. (2010). Nasal Reconstruction after Malignant Tumor Resection: An Algorithm for Treatment. Plastic and Reconstructive Surgery, 126(1), 97-105. Nijhuis, T.H.J., Brzezicki, G, Klimczak, A & Siemionow, M (2010). ISOGENIC VENOUS GRAFT SUPPORTED WITH BONE MARROW STROMAL CELLS AS A NATURAL CONDUIT FOR BRIDGING A 20 mm NERVE GAP. Microsurgery, 30(8), 639-645. Nijhuis, T.H.J., Smits, E.S., Jaquet, J.B., Oosterom, F.J.T. van, Selles, R.W. & Hovius, S.E.R. (2010). PREVALENCE AND SEVERITY OF COLD INTOLERANCE IN PATIENTS AFTER HAND FRACTURE. Journal of Hand Surgery-European Volume, 35E(4), 306-311. Nout, E., Mathijssen, I.M.J., Meulen, J.J.N.M. van der, Veelen, M.L.C. van, Koning, A.H.J., Lequin, M.H. & Wolvius, E.B. (2010). Internal carotid dissection after Le Fort III distraction in Apert syndrome: A case report. Journal of Cranio-Maxillofacial Surgery, 38(7), 529-533. Nout, E., Bouw, F.P., Veenland, J.F., Hop, W.C.J., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2010). Three- Dimensional Airway Changes after Le Fort III Advancement in Syndromic Craniosynostosis Patients. Plastic and Reconstructive Surgery, 126(2), 564-571. 224

Ongkosuwito, E.M., Gijt, P de, Wattel, E, Carels, CEL & Kuijpers-Jagtman, A.M. (2010). Dental Development in Hemifacial Microsomia. Journal of Dental Research, 89(12), 1368-1372. Pourrier, SD, Nieuwstraten, W., Cranenburgh, B Van, Schreuders, A.R., Stam, H.J. & Selles, R.W. (2010). Three cases of referred sensation in traumatic nerve injury of the hand: implication for understanding central nervous system reorganization. Journal of Rehabilitation Medicine, 42(4), 357-361. Rath, S., Schreuders, A.R., Stam, H.J., Hovius, S.E.R. & Selles, R.W. (2010). Early Active Motion versus Immobilization after Tendon Transfer for Foot Drop Deformity: A Randomized Clinical Trial. Clinical Orthopaedics & Related Research, 468(9), 2477-2484. Rath, S., Schreuders, A.R. & Selles, R.W. (2010). Early postoperative active mobilisation versus immobilisation following tibialis posterior tendon transfer for foot-drop correction in patients with Hansen's disease. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(3), 554-560. Rozendaal, A.M., Luijsterburg, A.J.M., Mohangoo, A.D., Ongkosuwito, E.M., Anthony, S. & Vermeij-Keers, C. (2010). Validation of the NVSCA Registry for Common Oral Clefts: Study Design and First Results. Cleft Palate-Craniofacial Journal, 47(5), 534-543. Schuitema, O.P., Mathijssen, I.M.J. & Mureau, M.A.M. (2010). Reconstruction of an extensive traumatic hemipelvectomy defect using a free lower leg fillet flap. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(1), E116-E117. Soeters, J.N.M., Selles, R.W. & Stam, H.J. (2010). Intrinsic plus positioning of fingers due to bowstringing at the metacarpophalangeal joint. Journal of Hand Surgery-European Volume, 35E(2), 150-151. Spaans, AJ, Slijper, H.P., Moojen, TM & Feitz, R. (2010). Open wedge correctieosteotomie voor malunited extra-articulaire distale radiusfracturen. Nederlands Tijdschrift voor Plastische Chirurgie, 1, 14-20. Spiegelberg, L., Djasim, U.M., Neck, J.W. van, Wolvius, E.B. & Wal, K.G.H. van der (2010). Hyperbaric Oxygen Therapy in the Management of Radiation-Induced Injury in the Head and Neck Region: A Review of the Literature. Journal of Oral and Maxillofacial Surgery, 68(8), 1732-1739. Stenekes, MW, Coert, J.H., Nicolai, JPA, Mulder, T., Geertzen, JHB, Paans, AM & Jong, B.M. de (2010). Cerebral consequences of dynamic immobilisation after primary digital flexor tendon repair. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(12), 1953-1961. Stokvis, A., Coert, J.H. & Neck, J.W. van (2010). Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(9), 1538-1543. Stokvis, A., Avoort, D.J.J.C. van der, Neck, J.W. van, Hovius, S.E.R. & Coert, J.H. (2010). Surgical management of neuroma pain: A prospective follow-up study. Pain, 151(3), 862-869. Twigg, SRF, Wilkie, A.O.M., Versnel, S.L. & Mathijssen, I.M.J. (2010). Median facial cleft dysmorphism in three siblings: case report and review of the literature. Cleft Palate-Craniofacial Journal, 47(4), 430-430. Verseijden, F., Sluijs, S.J. van, Farrell, E.J., Neck, J.W. van, Hovius, S.E.R., Hofer, S.O.P. & Osch, G.J.V.M. van (2010). Prevascular Structures Promote Vascularization in Engineered Human Adipose Tissue Constructs Upon Implantation. Cell Transplantation, 19(8), 1007-1020. Versnel, S.L., Duivenvoorden, H.J., Passchier, J. & Mathijssen, I.M.J. (2010). Satisfaction with facial appearance and its determinants in adults with severe congenital facial disfigurement: A case-referent study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(10), 1642-1649. Visser, N.J., Damen, T.H.C., Timman, R., Hofer, S.O.P. & Mureau, M.A.M. (2010). Surgical Results, Aesthetic Outcome, and Patient Satisfaction after Microsurgical Autologous Breast Reconstruction following Failed Implant Reconstruction. Plastic and Reconstructive Surgery, 126(1), 26-36. Walbeehm, E.T. (2010). European locums Reconsider the locum system. British Medical Journal, 340. Walbeehm, E.T. (2010). Locum issues Time to tackle the system. British Medical Journal, 341. Zuidam, J.M., Kraker, M. de, Selles, R.W. & Hovius, S.E.R. (2010). Evaluation of Function and Appearance of Adults With Untreated Triphalangeal Thumbs. Journal of Hand Surgery-American Volume, 35A(7), 1146-1152. Zuidam, J.M., Dees, E.E.C., Selles, R.W. & Hovius, S.E.R. (2010). IMPLICATIONS FOR TREATMENT OF VARIATIONS IN LENGTH OF THE FIRST METACARPAL IN DIFFERENT TYPES OF TRIPHALANGEAL THUMBS. Journal of Hand Surgery- European Volume, 35E(1), 65-69. Zuijdendorp, H.M., Tra, W.M.W., Neck, J.W. van, Mollis, L & Coert, J.H. (2010). Delay of denervation atrophy by sensory protection in an end-to-side neurorrhaphy model: A pilot study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(12), 1949-1952. Part of book - abstract Hovius, S.E.R. & Nieuwenhoven, C.A. van (2010). Clinical: Section VI Nerves: Nerve compression syndromes of the upper limb. In JR Urbaniak (Ed.), Hand Surgery Worldwide, International Reconstruction of a Beautiful and Ready Instrument of the Mind (pp. 359-370). 225

Hovius, S.E.R. (2010). Post traumatic Stress Disorder (PTSD). In FESSH 2010 Bucharest, Instructional Course (pp. 31-36). Meulen, J.C. van der, Groot Swanson, G de & Hovius, S.E.R. (2010). History: The Netherlands. In JR Urbaniak (Ed.), Hand Surgery Worldwide, International Reconstruction of a Beautiful and ready instrument of the mind (pp. 203-209). Nieuwenhoven, C.A. van & Hovius, S.E.R. (2010). Carpal Tunnel Syndrome in Children. In Moon Sang Chung (Ed.), Hand Surgery 2010 IFSSH (International Federation of Societies for Surgery of the Hand (pp. 145-148). 226

EMC NIHES-01-64-01 - Epidemiology of diseases Programme in brief design This program includes scientific research in cardiovascular epidemiology, neuroepidemiology and ophthalmologic epidemiology. Cardiovascular epidemiologic research focuses on the determinants of atherosclerosis and coronary heart disease in the elderly, and on cardiovascular diseases in women. The research is based on the Rotterdam Study and addresses inflammation markers and hemostasis as determinants of cardiovascular diseases in the elderly, and the effects of menopause, endogenous hormones and hormone replacement therapy in women. Neuroepidemiologic research focuses on the etiology of neurodegenerative and cerebrovascular diseases, including dementia and Alzheimer's disease, Parkinson's disease, stroke and cerebral white matter lesions. The research emphasizes the role of vascular factors in the etiology of these diseases, with use of state of the art neuroimaging techniques. Ophthalmological epidemiologic research focuses on determinants of macula degeneration and glaucoma. The emphasis is on the putative role of genetic factors and vascular factors in etiology of these diseases. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 3,23 10,68 3,08 0,75 17,74 internal medicine 0 1,5 0 0 1,5 neurology 0,2 0 0 0 0,2 Total 3,43 12,18 3,08 0,75 19,44 2 0 0 2 127 0 0 129 Thesis Dehghan, A. (2010, maart 31). Novel risk factors for type II diabetes mellitus and coronary heart disease. EUR. Prom./coprom.: Prof. Dr. J.C.M. Witteman & Prof. Dr. E.J.G. Sijbrands. Mook-Kanamori, D.O. (2010, november 24). Genetic and environmental influences on early growth. The Generation R Study. EUR (241 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof. Dr. A. Hofman, Prof. Dr. E.A.P. Steegers & Dr. V.W.V.K. Jaddoe. Artikel/Letter to the editor Alberts, VP, Bos, M.J., Koudstaal, P.J., Hofman, A., Witteman, J.C.M., Stricker, B.H.C. & Breteler, M.M.B. (2010). Heart failure and the risk of stroke: the Rotterdam Study. European Journal of Epidemiology, 25(11), 807-812. Anttila, V, Stefansson, H, Kallela, M, Todt, U, Terwindt, G.M., Calafato, MS, Nyholt, DR, Dimas, AS, Freilinger, T, Muller- Myhsok, B, Artto, V, Inouye, M, Alakurtti, K, Kaunisto, MA, Hamalainen, E, Vries, B de, Stam, AH, Weller, CM, Heinze, A, Heinze-Kuhn, K, Goebel, I, Borck, G, Gobel, H, Steinberg, S, Wolf, C, Bjornsson, A, Gudmundsson, G, Kirchmann, M, Hauge, A, Werge, T, Schoenen, J., Eriksson, JG, Hagen, K, Stovner, L, Wichmann, E, Meitinger, T, Alexander, M, Moebus, S, Schreiber, S., Aulchenko, Y.S., Breteler, M.M.B., Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Tikka-Kleemola, P, Vepsalainen,., Lucae, S, Tozzi, F, Muglia, P, Barrett, J, Kaprio, J, Farkkila, M, Peltonen, L., Stefansson, K, Zwart, JA, Ferrari, M.D., Olesen, J, Daly, M., Wessman, M, Maagdenberg, A.M.J.M., Dichgans, M, Kubisch, C, Dermitzakis, ET, Frants, R.R. & Palotie, A (2010). Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature Genetics, 42(10), 869-873. Baas, DC, Ho, L., Ennis, S, Merriam, JE, Tanck, M.W.T., Uitterlinden, A.G., Jong, P.T.V.M. de, Cree, AJ, Griffiths, HL, Rivadeneira, F., Hofman, A., Duijn, C.M. van, Smith, R.T., Barile, GR, Gorgels, TGMF, Vingerling, J.R., Klaver, C.C.W., Lotery, AJ, Allikmets, R. & Bergen, A.A.B. (2010). The Complement Component 5 Gene and Age-Related Macular Degeneration. Ophthalmology, 117(3), 500-511. Baas, DC, Despriet, D.D., Gorgels, T.G.M.F., Bergeron-Sawitzke, J, Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Merriam, JE, Smith, R.T., Barile, GR, Brink, J.B., Vingerling, J.R., Klaver, C.C.W., Allikmets, R., Dean, M & Bergen, A.A.B. (2010). The ERCC6 Gene and Age-Related Macular Degeneration. PLoS One, 5(11). Bakker, R., Pluimgraaff, L.E., Steegers, E.A.P., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Associations of light and moderate maternal alcohol consumption with fetal growth characteristics in different periods of pregnancy: The Generation R Study. International Journal of Epidemiology, 39(3), 777-789. Bakker, R., Steegers, E.A.P., Obradov, A, Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. American Journal of Clinical Nutrition, 91(6), 1691-1698. Bakker, R., Steegers, E.A.P., Mackenbach, J.P., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal smoking and blood pressure in different trimesters of pregnancy: The Generation R Study. Journal of Hypertension, 28(11), 2210-2218. Barbalic, M, Dupuis, J, Dehghan, A., Bis, JC, Hoogeveen, RC, Schnabel, RB, Nambi, V, Bretler, M, Smith, NL, Peters, A., Lu, C, Tracy, RP, Aleksic, N, Heeriga, J, Keaney, JF, Rice, K, Lip, G.Y.H., Vasan, RS, Glazer, NL, Larson, MG, Uitterlinden, A.G., Yamamoto, J, Durda, P, Haritunians, T, Psaty, B.M., Boerwinkle, E., Hofman, A., Koenig, W., Jenny, NS, Witteman, J.C.M., Ballantyne, C. & Benjamin, EJ (2010). Large-scale genomic studies reveal central role of ABO in sp-selectin and sicam-1 levels. Human Molecular Genetics, 19(9), 1863-1872. 227

Batenburg-Eddes, T. van, Groot, L. de, Steegers, E.A.P., Hofman, A., Jaddoe, V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2010). Fetal Programming of Infant Neuromotor Development: The Generation R Study. Pediatric Research, 67(2), 132-137. Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pharmacoepidemiology and Drug Safety, 19(1), 75-81. Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenetics Genomics, 20(1), 38-44. Beurskens, L.W.J.E., Tibboel, D., Lindemans, J., Duvekot, J.J., Overbeek, T.E., Veenma, D.C.M., Klein, A. de, Greer, JJ & Steegers-Theunissen, R.P.M. (2010). Retinol Status of Newborn Infants Is Associated With Congenital Diaphragmatic Hernia. Pediatrics, 126(4), 712-720. Blauw, HM, Al-Chalabi, A, Andersen, PM, Vught, PWJ Van, Diekstra, FP, Es, MA van, Saris, CGJ, Groen, EJN, Rheenen, W van, Koppers, M, Slot, R van 't, Strengman, E., Estrada, K, Rivadeneira, F., Hofman, A., Uitterlinden, A.G., Kiemeney, LA, Vermeulen, SHM, Birve, A, Waibel, S, Meyer, T, Cronin, S, McLaughlin, RL, Hardiman, O, Sapp, PC, Tobin, MD, Wain, LV, Tomik, B, Slowik, A, Lemmens, R, Rujescu, D, Schulte, C, Gasser, T., Brown, RH, Landers, JE, Robberecht, W, Ludolph, A.C., Ophoff, R.A., Veldink, J.H. & Berg, L.H. van den (2010). A large genome scan for rare CNVs in amyotrophic lateral sclerosis. Human Molecular Genetics, 19(20), 4091-4099. Blom, E.A., Jansen, P.W., Verhulst, F.C., Hofman, A., Raat, H., Jaddoe, V.W.V.K., Coolman, M., Steegers, E.A.P. & Tiemeier, H.W. (2010). Perinatal complications increase the risk of postpartum depression. The Generation R Study. 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Dietary Antioxidants and Long-term Risk of Dementia. Archives of Neurology, 67(7), 819-825. Duijts, L., Jaddoe, V.W.V.K., Hofman, A. & Moll, H.A. (2010). Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy. Pediatrics, 126(1), E18-E25. Durme, Y.M.T.A. van, Eijgelsheim, M., Joos, G.F., Hofman, A., Uitterlinden, A.G., Brusselle, GG & Stricker, B.H.C. (2010). Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. European Respiratory Journal, 36(1), 89-95. Durmus, B., Mook-Kanamori, D.O., Holzhauer, S., Hofman, A., Beek, E.M. van der, Boehm, G., Steegers, E.A.P. & Jaddoe, V.W.V.K. (2010). Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: The Generation R Study. Clinical Endocrinology, 72(5), 633-640. 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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42(5), 430- U73. Geelhoed, J.J.M., Taal, H.R., Steegers, E.A., Arends, L.R., Lequin, M., Moll, H.A., Hofman, A., Heijden, A.J. van der & Jaddoe, V.W.V.K. (2010). Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatric Nephrology, 25(2), 289-298. Geelhoed, M.J.J., Steegers, E.A.P., Koper, J.W., Rossum, E.F.C. van, Moll, H.A., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Glucocoricoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. BMC Medical Genetics, 11(39). Gelok, S., Janssens, A.C.J.W., Tiemeier, H.W., Liu, F., Lopez-Leon, S, Zorkoltseva, IV, Axenovich, T.I., Swieten, J.C. van, Uitterlinden, A.G., Hofman, A., Aulchenko, Y.S., Oostra, B.A. & Duijn, C.M. van (2010). A Genome-Wide Screen for Depression in Two Independent Dutch Populations. Biological Psychiatry, 68(2), 187-196. Groen, E. de, Mohangoo, A.D., Jongste, J.C. de, Wouden, J.C. van der, Moll, H.A., Jaddoe, V.W.V.K., Hofman, A., Koning, H.J. de & Raat, H. (2010). Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial. Bmc Public Health, 10, 555. Groen, H.C., Simons, L., Bouwhuijsen, Q.J.A. van den, Bosboom, EMH, Gijsen, F.J.H., Giessen, A.G. van der, Vosse, F.N. van de, Hofman, A., Steen, A.F.W. van der, Witteman, J.C.M., Lugt, A. van der & Wentzel, J.J. (2010). MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries. Journal of Biomechanics, 43(12), 2332-2338. 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Neurobiology of Aging, 31(3), 378-386. Ikram, M.A., Luijendijk, H.J., Vernooij, M.W., Hofman, A., Niessen, W.J., Lugt, A. van der, Tiemeier, H.W. & Breteler, M.M.B. (2010). Vascular Brain Disease and Depression in the Elderly. Epidemiology, 21(1), 78-81. Ikram, M.K., Xueling, S, Jensen, RA, Cotch, MF, Hewitt, AW, Ikram, M.A., Wang, J.J., Klein, R., Klein, B.E.K., Breteler, M.M.B., Cheung, N, Liew, G., Mitchell, P., Uitterlinden, A.G., Rivadeneira, F., Hofman, A., Jong, P.T.V.M. de, Duijn, C.M. van, Kao, L, Cheng, CY, Smith, AV, Glazer, NL, Lumley, T, McKnight, B, Psaty, B.M., Jonasson, F, Eiriksdottir, G, Aspelund, T, Harris, T.B., Launer, L.J., Taylor, KD, Li, XH, Iyengar, SK, Xi, QS, Sivakumaran, TA, Mackey, DA, Macgregor, S, Martin, NG, Young, TL, Bis, JC, Wiggins, KL, Heckbert, SR, Hammond, CJ, Andrew, T., Fahy, S, Attia, J, Holliday, EG, Scott, R.J., Islam, FMA, Rotter, JI, McAuley, AK, Boerwinkle, E., Tai, ES, Gudnason, V, Siscovick, D.S., Vingerling, J.R. & Wong, TY (2010). 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Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), 1068-1076. Struchalin, M.V., Dehghan, A., Witteman, J.C.M., Duijn, C.M. van & Aulchenko, Y.S. (2010). Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations. Bmc Genetics, 11. 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Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), 448-U135. Tripepi, G, Mattace Raso, F.U.S., Rapisarda, F, Stancanelli, B, Malatino, L, Witteman, J.C.M., Zoccali, C & Mallamaci, F (2010). Traditional and nontraditional risk factors as predictors of cerebrovascular events in patients with end stage renal disease. Journal of Hypertension, 28(12), 2468-2474. Vegt, E.J.M. van der, Ende, J. van der, Huizink, A.C., Verhulst, F.C. & Tiemeier, H.W. (2010). Childhood Adversity Modifies the Relationship Between Anxiety Disorders and Cortisol Secretion. Biological Psychiatry, 68(11), 1048-1054. Vergeer, M, Boekholdt, S.M., Sandhu, MS, Ricketts, SL, Wareham, NJ, Brown, MJ, Faire, U de, Leander, K, Gigante, B, Kavousi, M., Hofman, A., Uitterlinden, A.G., Duijn, C.M. van, Witteman, J.C.M., Jukema, J.W., Schadt, EE, Schoot, E. van der, Kastelein, J.J.P., Khaw, KT, Dullaart, R.P.F., Tol, A. van, Trip, M.D. & Dallinga-Thie, G.M. (2010). 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Visser, A.M., Jaddoe, V.W.V.K., Arends, L.R., Tiemeier, H.W., Hofman, A., Moll, H.A., Steegers, E.A.P., Breteler, M.M.B. & Arts, W.F.M. (2010). Paroxysmal disorders in infancy and their risk factors in a population-based cohort: the Generation R Study. Developmental Medicine & Child Neurology, 52(11), 1014-1020. Wang, T.J., Zhang, F., Richards, JB, Kestenbaum, B, Meurs, J.B.J. van, Berry, D, Kiel, DP, Streeten, EA, Ohlsson, C, Koller, DL, Peltonen, L., Cooper, JD, O'Reilly, PF, Houston, DK, Glazer, NL, Vandenput, L, Peacock, M., Shi, J, Rivadeneira, F., McCarthy, MI, Anneli, P, Boer, I.H., Mangino, M, Kato, B, Smyth, DJ, Booth, SL, Jacques, PF, Burke, GL, Goodarzi, M, Cheung, C., Wolf, M. van der, Rice, K, Goltzman, D, Hidiroglou, N, Ladouceur, M, Wareham, NJ, Hocking, LJ, Hart, D. t, Arden, NK, Cooper, C., Malik, S, Fraser, WD, Hartikainen, AL, Zhai, GJ, Macdonald, HM, Forouhi, NG, Loos, RJF, Reid, D.M., Hakim, A., Dennison, E, Liu, YM, Power, C, Stevens, HE, Jaana, L, Vasan, RS, Soranzo, N, Bojunga, J, Psaty, B.M., Lorentzon, M, Foroud, T., Harris, T.B., Hofman, A., Jonsson, JO, Cauley, J.A., Uitterlinden, A.G., Gibson, Q, Jarvelin, MR, karasik, D., Siscovick, D.S., Econs, M.J., Kritchevsky, SB, Florez, JC, Todd, JA, Dupuis, J, Hypponen, E & Spector, T.D. (2010). Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (UK), 376(9736), 180-188. Waterworth, D.M., Ricketts, SL, Song, KJ, Chen, L., Zhao, JH, Ripatti, S, Aulchenko, Y.S., Zhang, WH, Yuan, X, Lim, N, Luan, JA, Ashford, S, Wheeler, E, Young, EH, Hadley, D, Thompson, JR, Braund, PS, Johnson, T, Struchalin, M, Surakka, I, Luben, R, Khaw, KT, Rodwell, SA, Loos, RJF, Boekholdt, S.M., Inouye, M, Deloukas, P, Elliott, P, Schlessinger, D, Sanna, S, Scuteri, A, Jackson, A, Mohlke, KL, Tuomilehto, J, Roberts, R., Stewart, A, Kesaniemi, YA, Mahley, RW, Grundy, S.M., McArdle, W, Cardon, L., Waeber, G, Vollenweider, P, Chambers, JC, Boehnke, M, Abecasis, GR, Salomaa, V, Jarvelin, MR, Ruokonen, A, Barroso, I, Epstein, SE, Hakonarson, HH, Rader, DJ, Reilly, MP, Witteman, J.C.M., Hall, AS, Samani, NJ, Strachan, DP, Barter, P., Duijn, C.M. van, Kooner, JS, Peltonen, L., Wareham, NJ, McPherson, R, Mooser, V & Sandhu, MS (2010). Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease. Arteriosclerosis Thrombosis & Vascular Biology, 30(11), 2264-U566. Wieberdink, R.G., Schie, M.C. van, Koudstaal, P.J., Hofman, A., Witteman, J.C.M., Maat, M.P.M. de, Leebeek, F.W.G. & Breteler, M.M.B. (2010). High von Willebrand Factor Levels Increase the Risk of Stroke The Rotterdam Study. Stroke, 41(10), 2151-2156. Wieberdink, R.G., Ikram, M.K., Koudstaal, P.J., Hofman, A., Vingerling, J.R. & Breteler, M.M.B. (2010). Retinal Vascular Calibers and the Risk of Intracerebral Hemorrhage and Cerebral Infarction The Rotterdam Study. Stroke, 41(12), 2757-2761. Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Passchier, J. & Tiemeier, H.W. (2010). Determinants of Somatic Complaints in 18-month-old Children: The Generation R Study. Journal of Pediatric Psychology, 35(3), 306-316. Zillikens, M.C., Meurs, J.B.J. van, Rivadeneira, F., Hofman, A., Oostra, B.A., Sijbrands, E.J.G., Witteman, J.C.M., Pols, H.A.P., Duijn, C.M. van & Uitterlinden, A.G. (2010). Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index. American Journal of Clinical Nutrition, 91(5), 1387-1393. 235

EMC NIHES-01-64-02 - Basic epidemiologic research Programme in brief design This program includes research in the fields of genetic epidemiology and endocrinologic epidemiology. Genetic epidemiologic research aims at quantifying the population risk of disorders associated with genetic risk factors and at identifying new genetic factors involved in complex genetic disorders. For the empirical studies, the emphasis is on neurodegenerative and neurovascular disorders. The work in endocrinologic epidemiology focuses on the question whether circulating hormone levels are associated with incident diseases of the elderly and with parameters of frailty. The emphasis is on determinants of locomotor diseases (osteoporosis, osteoarthritis) and on sex hormones and thyroid hormones as determinants of disease. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 1,75 8,19 2,84 0,25 13,03 gynaecology/obstetrics 0,2 0 0 0 0,2 neurology 0 0,5 0 0 0,5 Total 1,95 8,69 2,84 0,25 13,73 4 0 0 4 95 3 1 103 Thesis Beurskens, L.W.J.E. (2010, november 24). A black hole? Epidemiological and molecular biological studies on the etiology of congenital diaphragmatic hernia. EUR (168 pag.). Prom./coprom.: Prof.Dr. D. Tibboel & Prof. Dr. R.P.M. Steegers-Theunissen. Schuur, M. (2010, mei 12). Genetic determinants of cognitive function and age-related brain changes. EUR (237 pag.). Prom./coprom.: Prof. Dr. Ir. C.M. van Duijn, Prof. Dr. B.A. Oostra & Dr. J.C. van Swieten. Timmermans, S. (2010, september 15). Folic Acid, dietary patterns and perinatal health. The Generation R study. EUR. Prom./coprom.: Prof. Dr. E.A.P. Steegers & Prof. Dr. R.P.M. Steegers-Theunissen. Vujkovic, M. (2010, oktober 20). Dietary patterns and human reproduction. EUR. Prom./coprom.: Prof. Dr. E.A.P. Steegers & Prof. Dr. R.P.M. Steegers-Theunissen. Artikel/Letter to the editor Anttila, V, Stefansson, H, Kallela, M, Todt, U, Terwindt, G.M., Calafato, MS, Nyholt, DR, Dimas, AS, Freilinger, T, Muller- Myhsok, B, Artto, V, Inouye, M, Alakurtti, K, Kaunisto, MA, Hamalainen, E, Vries, B de, Stam, AH, Weller, CM, Heinze, A, Heinze-Kuhn, K, Goebel, I, Borck, G, Gobel, H, Steinberg, S, Wolf, C, Bjornsson, A, Gudmundsson, G, Kirchmann, M, Hauge, A, Werge, T, Schoenen, J., Eriksson, JG, Hagen, K, Stovner, L, Wichmann, E, Meitinger, T, Alexander, M, Moebus, S, Schreiber, S., Aulchenko, Y.S., Breteler, M.M.B., Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Tikka-Kleemola, P, Vepsalainen,., Lucae, S, Tozzi, F, Muglia, P, Barrett, J, Kaprio, J, Farkkila, M, Peltonen, L., Stefansson, K, Zwart, JA, Ferrari, M.D., Olesen, J, Daly, M., Wessman, M, Maagdenberg, A.M.J.M., Dichgans, M, Kubisch, C, Dermitzakis, ET, Frants, R.R. & Palotie, A (2010). Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nature Genetics, 42(10), 869-873. Aulchenko, Y.S., Struchalin, M.V. & Duijn, C.M. van (2010). ProbABEL package for genome-wide association analysis of imputed data. Bmc Bioinformatics, 11. Baas, DC, Ho, L., Ennis, S, Merriam, JE, Tanck, M.W.T., Uitterlinden, A.G., Jong, P.T.V.M. de, Cree, AJ, Griffiths, HL, Rivadeneira, F., Hofman, A., Duijn, C.M. van, Smith, R.T., Barile, GR, Gorgels, TGMF, Vingerling, J.R., Klaver, C.C.W., Lotery, AJ, Allikmets, R. & Bergen, A.A.B. (2010). The Complement Component 5 Gene and Age-Related Macular Degeneration. Ophthalmology, 117(3), 500-511. Baas, DC, Despriet, D.D., Gorgels, T.G.M.F., Bergeron-Sawitzke, J, Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Merriam, JE, Smith, R.T., Barile, GR, Brink, J.B., Vingerling, J.R., Klaver, C.C.W., Allikmets, R., Dean, M & Bergen, A.A.B. (2010). The ERCC6 Gene and Age-Related Macular Degeneration. PLoS One, 5(11). Bakker, R., Pluimgraaff, L.E., Steegers, E.A.P., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Associations of light and moderate maternal alcohol consumption with fetal growth characteristics in different periods of pregnancy: The Generation R Study. International Journal of Epidemiology, 39(3), 777-789. Bakker, R., Steegers, E.A.P., Obradov, A, Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. American Journal of Clinical Nutrition, 91(6), 1691-1698. Batenburg-Eddes, T. van, Groot, L. de, Steegers, E.A.P., Hofman, A., Jaddoe, V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2010). Fetal Programming of Infant Neuromotor Development: The Generation R Study. Pediatric Research, 67(2), 132-137. Blom, E.A., Jansen, P.W., Verhulst, F.C., Hofman, A., Raat, H., Jaddoe, V.W.V.K., Coolman, M., Steegers, E.A.P. & Tiemeier, H.W. (2010). Perinatal complications increase the risk of postpartum depression. The Generation R Study. Bjog-An International Journal of Obstetrics and Gynaecology, 117(11), 1390-1398. Bon, E., Steegers-Theunissen, R.P.M., Steegers, E.A.P., Ursem, N.T.C., Charif, H., Burgers, P.C., Luider, T.M. & Dekker, L.J.M. (2010). Proteomic Analyses of the Developing Chicken Cardiovascular System. Journal of Proteome Research, 9(1), 268-274. 236

Brugts, J.J., Isaacs, A.J., Boersma, E., Duijn, C.M. van, Uitterlinden, A.G., Remme, W, Bertrand, M, Ninomiya, T, Ceconi, C., Chalmers, J, MacMahon, S, Fox, K, Ferrari, R., Witteman, J.C.M., Danser, A.H.J., Simoons, M.L. & Maat, M.P.M. de (2010). Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. European Heart Journal, 31(15), 1854-1864. Brugts, M.P., Duijn, C.M. van, Hofland, L.J., Witteman, J.C.M., Lamberts, S.W.J & Janssen, J.A.M.J.L. (2010). IGF-I Bioactivity in an Elderly Population Relation to Insulin Sensitivity, Insulin Levels, and the Metabolic Syndrome. Diabetes, 59(2), 505-508. Collins, SJ, Schuur, M., Boyd, A, Lewis, V., Klug, GM, McGlade, A, Oosterhout, A van, Breedveld, G.J., Oostra, B.A., Masters, C & Duijn, C.M. van (2010). No evidence for prion protein gene locus multiplication in Creutzfeldt-Jakob disease. Neuroscience Letters, 472(1), 16-18. Combarros, O, Warden, DR, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, MG, Wilcock, GK, Brown, K., Kehoe, PG, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kolsch, H, Mateo, I, Oulhaj, A, Arias-Vasquez, A, Schuur, M., Aulchenko, Y.S., Ikram, M.A., Breteler, M.M.B., Duijn, C.M. van, Morgan, K., Smith, AD & Lehmann, DJ (2010). The dopamine beta-hydroxylase-1021c/t polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. BMC Medical Genetics, 11. Coolman, M., Groot, C.J.M. de, Jaddoe, V.W.V.K., Hofman, A., Raat, H. & Steegers, E.A.P. (2010). Medical record validation of maternally reported history of preeclampsia. Journal of Clinical Epidemiology, 63(8), 932-937. Coppus, A.M.W., Evenhuis, H.M., Verberne, GJ, Visser, FE, Eikelenboom, P., Gool, W.A. van, Janssens, A.C.J.W. & Duijn, C.M. van (2010). Early Age at Menopause is Associated with Increased risk of Dementia and Mortality in Women with Down Syndrome. Journal of Alzheimers Disease, 19(2), 545-550. Coppus, A.M.W., Fekkes, D., Verhoeven, W.M.A., Tuinier, S. & Duijn, C.M. van (2010). Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations. Amino Acids, 38(3), 923-928. Debette, S, Bis, JC, Fornage, M, Schmidt, H., Ikram, M.A., Sigurdsson, S, Heiss, G, Struchalin, M, Smith, AV, Lugt, A. van der, DeCarli, C., Lumley, T, Knopman, DS, Enzinger, C, Eiriksdottir, G, Koudstaal, P.J., DeStefano, AL, Psaty, B.M., Dufouil, C., Catellier, DJ, Fazekas, F., Aspelund, T, Aulchenko, Y.S., Beiser, A, Rotter, JI, Tzourio, C., Shibata, DK, Tscherner, M, Harris, T.B., Rivadeneira, F., Atwood, LD, Rice, K, Gottesman, RF, Buchem, M.A. van, Uitterlinden, A.G., Kelly-Hayes, M, Cushman, M., Zhu, YC, Boerwinkle, E., Gudnason, V, Hofman, A., Romero, JR, Lopez, O, Duijn, C.M. van, Au, R., Heckbert, SR, Wolf, PA, Mosley, TH, Seshadri, S, Breteler, M.M.B., Schmidt, R., Launer, L.J. & Longstreth, W.T. (2010). Genome-Wide Association Studies of MRI-Defined Brain Infarcts Meta-Analysis From the CHARGE Consortium. Stroke, 41(2), 210-217. Diemen, CC van, Postma, D.S., Aulchenko, Y.S., Snijders, P.J.L.M., Oostra, B.A., Duijn, C.M. van & Boezen, H.M. (2010). Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate. European Respiratory Journal, 35(4), 768-775. Duijts, L., Jaddoe, V.W.V.K., Hofman, A. & Moll, H.A. (2010). Prolonged and Exclusive Breastfeeding Reduces the Risk of Infectious Diseases in Infancy. Pediatrics, 126(1), E18-E25. 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Computational Biology and Chemistry, 34(4), 242-243. Zubakov, D., Liu, F., Zelm, M.C. van, Vermeulen, J., Oostra, B.A., Duijn, C.M. van, Driessen, G.J.A., Dongen, J.J.M. van, Kayser, M.H. & Langerak, A.W. (2010). Estimating human age from T-cell DNA rearrangements. Current Biology, 20(22), R970- R971. Part of book - abstract Twigt, J.M., Laven, J.S.E. & Steegers-Theunissen, R.P.M. (2010). Folate in human reproductive performance. In H Obeid (Ed.), Vitamins in the prevention of human diseases. Berlin: De Gruyter STM Medicine. 242

EMC NIHES-01-64-03 - Clinical epidemiology Programme in brief design This program comprises three parts: clinical epidemiology in collaboration with radiology, biostatistics and pharmacoepidemiology. The clinical epidemiology group collaborates with the department of radiology in a joint research program for the Assessment of Radiological Technology (ART program). This program s research focuses on the assessment of medical imaging technology, especially diagnostic imaging but also image-guided therapies, with an emphasis on cardiovascular disease. Methodological research in the ART program focuses on developing the methods for evaluating diagnostic imaging procedures using stochastic modeling and utility assessment related to diagnostic testing and therapeutic outcomes. The biostatistics group provides quantitative support for various studies in the Erasmus MC. For its own research, the biostatistics group focuses on the application of new developments in statistics, such as new analytic methods for dependent observations, like random effect models, Baysian methods and sequential analysis. Pharmaco-epidemiologic research focuses on intended effects of medications, and the effects of medication use under common circumstances in large populations. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 2,95 2,95 1 1,5 8,4 immunology 0 0 0 0 0 internal medicine 0 0 0 0 0 medical ethics and philosophy of medicine 0 0,8 0 0 0,8 Total 2,95 3,75 1 1,5 9,2 2 0 0 2 53 2 0 57 Thesis Berg- de Lange, C. van den (2010, december 09). The contribution of acupuncture and moxibustion to healthcare an evidencebased approach. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. J.J. Duvekot. Luijendijk, H.J. (2010, februari 10). Vascular heart and brain disease and incident late-life depression. EUR. Prom./coprom.: Prof. Dr. B.H.C. Stricker & Dr. H.W. Tiemeier. Artikel/Letter to the editor Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pharmacoepidemiology and Drug Safety, 19(1), 75-81. Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenetics Genomics, 20(1), 38-44. Berg, I. van den, Kaandorp, G.C., Bosch, J.L., Duvekot, J.J., Arends, L.R. & Hunink, M.G.M. (2010). Cost-effectiveness of breech version by acupuncture-type interventions on BL 67, including moxibustion, for women with a breech foetus at 33 weeks gestation: a modelling approach. Complementary Therapies in Medicine, 18(2), 67-77. Berg, I. van den, Tan, L., Brero, H van, Tan, KT, Cecile, A, Janssens, JW & Hunink, M.G.M. (2010). Health-related quality of life in patients with musculoskeletal complaints in a general acupuncture practice: an observational study. ACUPUNCTURE IN MEDICINE, 28(3), 130-135. Claassen, L, Henneman, L, Janssens, A.C.J.W., Wijdenes-Pijl, M, Qureshi, N, Walter, FM, Yoon, PW & Timmermans, D.R.M. (2010). Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence. Bmc Public Health, 10. Coppus, A.M.W., Evenhuis, H.M., Verberne, GJ, Visser, FE, Eikelenboom, P., Gool, W.A. van, Janssens, A.C.J.W. & Duijn, C.M. van (2010). Early Age at Menopause is Associated with Increased risk of Dementia and Mortality in Women with Down Syndrome. Journal of Alzheimers Disease, 19(2), 545-550. Durme, Y.M.T.A. van, Eijgelsheim, M., Joos, G.F., Hofman, A., Uitterlinden, A.G., Brusselle, GG & Stricker, B.H.C. (2010). Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. European Respiratory Journal, 36(1), 89-95. Eijgelsheim, M., Newton-Cheh, C, Sotoodehnia, N, Bakker, PIW de, Muller, M., Morrison, AC, Smith, AV, Isaacs, A.J., Sanna, S, Dorr, M, Navarro, P, Fuchsberger, C, Nolte, I.M., Geus, E.J.C. de, Estrada, K, Hwang, SJ, Bis, JC, Ruckert, IM, Alonso, A., Launer, L.J., Hottenga, J.J., Rivadeneira Ramirez, F., Noseworthy, PA, Rice, KM, Perz, S, Arking, DE, Spector, T.D., Kors, J.A., Aulchenko, Y.S., Tarasov, KV, Homuth, G., Wild, SH, Marroni, F, Gieger, C, Licht, CM, Prineas, RJ, Hofman, A., Rotter, JI, Hicks, AA, Ernst, F, Najjar, SS, Wright, AF, Peters, A., Fox, ER, Oostra, B.A., Kroemer, HK, Couper, D, Volzke, H, Campbell, H, Meitinger, T, Uda, M, Witteman, J.C.M., Psaty, B.M., Wichmann, HE, Harris, T.B., Kaab, S, Siscovick, D.S., Jamshidi, Y, Uitterlinden, A.G., Folsom, A.R., Larson, MG, Wilson, JF, Penninx, BW, Snieder, H, Pramstaller, P.P., Duijn, C.M. van, Lakatta, EG, Felix, SB, Gudnason, V, Pfeufer, A, Heckbert, SR, Stricker, B.H.C., Boerwinkle, E. & O'Donnell, CJ (2010). Genome-wide association analysis identifies multiple loci related to resting heart rate. Human Molecular Genetics, 19(19), 3885-3894. Elias-Smale, S.E., Odink, A.E., Wieberdink, R.G., Hofman, A., Hunink, M.G.M., Krestin, G.P., Koudstaal, P.J., Breteler, M.M.B., Lugt, A. van der & Witteman, J.C.M. (2010). Carotid, aortic arch and coronary calcification are related to history of stroke: The Rotterdam Study. Atherosclerosis, 212(2), 656-660. 243

Elias-Smale, S.E., Proenca, RV, Koller, M.T., Kavousi, M., Rooij, F.J.A. van, Hunink, M.G.M., Steyerberg, E.W., Hofman, A., Oudkerk, M.. & Witteman, J.C.M. (2010). Coronary Calcium Score Improves Classification of Coronary Heart Disease Risk in the Elderly The Rotterdam Study. Journal of the American College of Cardiology, 56(17), 1407-1414. Ellinor, PT, Lunetta, KL, Glazer, NL, Pfeufer, A, Alonso, A., Chung, MK, Sinner, MF, Bakker, PIW de, Mueller, M, Lubitz, SA, Fox, E, Darbar, D, Smith, NL, Smith, JD, Schnabel, RB, Soliman, EZ, Rice, KM, Wagoner, DR Van, Beckmann, BM, Noord, C. van, Wang, K, Ehret, GB, Rotter, JI, Hazen, SL, Steinbeck, G, Smith, AV, Launer, L.J., Harris, T.B., Makino, S, Nelis, M, Milan, DJ, Perz, S, Esko, T, Kottgen, A, Moebus, S, Newton-Cheh, C, Li, M., Moehlenkamp, S, Wang, T.J., Kao, WHL, Vasan, RS, Nothen, MM, MacRae, CA, Stricker, B.H.C., Hofman, A., Uitterlinden, A.G., Levy, D., Boerwinkle, E., Metspalu, A, Topol, E.J., Chakravarti, A, Gudnason, V, Psaty, B.M., Roden, DM, Meitinger, T, Wichmann, HE, Witteman, J.C.M., Barnard, J, Arking, DE, Benjamin, EJ, Heckbert, SR & Kaab, S (2010). Common variants in KCNN3 are associated with lone atrial fibrillation. Nature Genetics, 42(3), 240-U36. Ferket, B.S., Kempen, B.J.H. van & Janssens, A.C.J.W. (2010). Assessing Predictive Performance Beyond the Framingham Risk Score. Jama - Journal of the American Medical Association, 303(14), 1368-1368. Ferket, B.S., Colkesen, EB, Visser, J.J., Spronk, S., Kraaijenhagen, RA, Steyerberg, E.W. & Hunink, M.G.M. (2010). Systematic Review of Guidelines on Cardiovascular Risk Assessment Which Recommendations Should Clinicians Follow for a Cardiovascular Health Check? Archives of Internal Medicine, 170(1), 27-40. Gelok, S., Janssens, A.C.J.W., Tiemeier, H.W., Liu, F., Lopez-Leon, S, Zorkoltseva, IV, Axenovich, T.I., Swieten, J.C. van, Uitterlinden, A.G., Hofman, A., Aulchenko, Y.S., Oostra, B.A. & Duijn, C.M. van (2010). A Genome-Wide Screen for Depression in Two Independent Dutch Populations. Biological Psychiatry, 68(2), 187-196. Genders, T.S.S., Pugliese, F., Mollet, N.R., Meijboom, W.B., Weustink, A.C., Mieghem, C.A.G. van, Feyter, P.J. de & Hunink, M.G.M. (2010). Incremental value of the CT coronary calcium score for the prediction of coronary artery disease. European Radiology, 20(10), 2331-2340. Groot Koerkamp, B., Weinstein, M.C., Stijnen, T., Heijenbrok-Kal, M.H. & Hunink, M.G.M. (2010). Uncertainty and Patient Heterogeneity in Medical Decision Models. Medical Decision Making, 30(2), 194-205. Groot Koerkamp, B., Spronk, S., Stijnen, T. & Hunink, M.G.M. (2010). Value of Information Analyses of Economic Randomized Controlled Trials: The Treatment of Intermittent Claudication. Value in Health, 13(2), 242-250. Grootenboer, N., Sambeek, M.R.H.M. van, Arends, L.R., Hendriks, J.M., Hunink, M.G.M. & Bosch, J.L. (2010). Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm. British Journal of Surgery, 97(8), 1169-1179. Hancock, DB, Eijgelsheim, M., Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, Durme, Y.M.T.A. van, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, B.M., Duijn, C.M. van, Rotter, JI, Uitterlinden, A.G., Hofman, A., Punjabi, NM, Rivadeneira Ramirez, F., Morrison, AC, Enright, P.L., North, KE, Heckbert, SR, Lumley, T, Stricker, B.H.C., O'Connor, GT & London, SJ (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics, 42(1), 45-U61. Hassan, C, Pickhardt, PJ, Giulio, E Di, Hunink, M.G.M., Zullo, A & Nardelli, BB (2010). Value-of-Information Analysis to Guide Future Research in the Management of the Colorectal Malignant Polyp. Diseases of the Colon & Rectum, 53(2), 135-142. Henneman, P., Janssens, A.C.J.W., Zillikens, M.C., Frolich, M, Frants, R.R., Oostra, B.A., Duijn, C.M. van & Dijk, KW van (2010). Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome. Journal of Internal Medicine, 267(4), 402-409. Janssens, A.C.J.W. & Duijn, C.M. van (2010). An epidemiological perspective on the future of direct-to-consumer personal genome testing. Investigative Genetics, 1, 10. Janssens, A.C.J.W. & Khoury, MJ (2010). Assessment of Improved Prediction Beyond Traditional Risk Factors When Does a Difference Make a Difference? Circulation-cardiovascular genetics, 3(1), 3-5. Janssens, A.C.J.W. (2010). Why Realistic Test Scenarios in Translational Genomics Research Remain Hypothetical. Public Health Genomics, 13(3), 166-168. Jong, A. de, Teeuw, M. & Janssens, A.C.J.W. (2010). Whole Genome Sequencing - nieuwe mogelijkheden voor de gezondheidszorg? Nederlands Tijdschrift voor Geneeskunde, 154, 2753. Kardys, I., Deckers, J.W., Stricker, B.H.C., Vletter, W.B., Hofman, A. & Witteman, J.C.M. (2010). Distribution of echocardiographic parameters and their associations with cardiovascular risk factors in the Rotterdam Study. European Journal of Epidemiology, 25(7), 481-490. Kaur, G, Verhamme, K.M.C., Dieleman, J.P., Vanrolleghem, A., Soest, E.M. van, Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2010). Association between calcium channel blockers and gingival hyperplasia. Journal of Clinical Periodontology, 37(7), 625-630. Kiiski, V, Vries, E. de, Flohil, S.C., Bijl, M.J., Hofman, A., Stricker, B.H.C. & Nijsten, T.E.C. (2010). Risk Factors for Single and Multiple Basal Cell Carcinomas. Archives of Dermatology, 146(8), 848-855. Leening, M.J.G., Elias-Smale, S.E., Felix, J.F., Kors, J.A., Deckers, J.W., Hofman, A., Stricker, B.H.C. & Witteman, J.C.M. (2010). Unrecognised myocardial infarction and long-term risk of heart failure in the elderly: the Rotterdam Study. Heart, 96(18), 1458-1462. 244

Liu, F., Pardo, LM, Schuur, M., Sanchez-Juan, P, Isaacs, A.J., Koning, I.V., Sleegers, K., Zorkoltseva, IV, Axenovich, T.I., Witteman, J.C.M., Janssens, A.C.J.W., Swieten, J.C. van, Aulchenko, Y.S., Oostra, B.A. & Duijn, C.M. van (2010). The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiology of Aging, 31(10), 1831-1833. Lopez Leon, S., Aulchenko, Y.S., Tiemeier, H.W., Oostra, B.A., Duijn, C.M. van & Janssens, A.C.J.W. (2010). Shared genetic factors in the co-occurrence of symptoms of depression and cardiovascular risk factors. Journal of Affective Disorders, 122(3), 247-252. Lubitz, SA, Sinner, MF, Lunetta, KL, Makino, S, Pfeufer, A, Rahman, R, Veltman, C.E., Barnard, J, Bis, JC, Danik, SP, Sonni, A, Shea, MA, Monte, F del, Perz, S, Muller, M., Peters, A., Greenberg, SM, Furie, KL, Noord, C. van, Boerwinkle, E., Stricker, B.H.C., Witteman, J.C.M., Smith, JD, Chung, MK, Heckbert, SR, Benjamin, EJ, Rosand, J, Arking, DE, Alonso, A., Kaab, S & Ellinor, PT (2010). Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25. Circulation, 122(10), 976- U66. Luijendijk, H.J., Tiemeier, H.W., Berg, J.F. van den, Bleumink, G.S., Hofman, A. & Stricker, B.H.C. (2010). Heart Failure and Incident Late-Life Depression. Journal of American Geriatrics Society, 58(8), 1441-1446. Mascalzoni, D, Janssens, A.C.J.W., Stewart, A, Pramstaller, P, Gyllensten, U, Rudan, I, Duijn, C.M. van, Wilson, JF, Campbell, H & Quillan, R Mc (2010). Comparison of participant information and informed consent forms of five European studies in genetic isolated populations. European Journal of Human Genetics, 18(3), 296-302. Mihaescu, R., Zitteren, M. van, Hoek, M. van der, Sijbrands, E.J.G., Uitterlinden, A.G., Witteman, J.C.M., Hofman, A., Hunink, M.G.M., Duijn, C.M. van & Janssens, A.C.J.W. (2010). Improvement of Risk Prediction by Genomic Profiling: Reclassification Measures Versus the Area Under the Receiver Operating Characteristic Curve. American Journal of Epidemiology, 172(3), 353-361. Mihaescu, R., Detmar, S.B., Cornel, MC, Flier, WM van der, Heutink, P., Hol, E.M., Rikkert, MGMO, Duijn, C.M. van & Janssens, A.C.J.W. (2010). Translational Research in Genomics of Alzheimer's Disease: A Review of Current Practice and Future Perspectives. Journal of Alzheimers Disease, 20(4), 967-980. Odink, A.E., Lugt, A. van der, Hofman, A., Hunink, M.G.M., Breteler, M.M.B., Krestin, G.P. & Witteman, J.C.M. (2010). Risk factors for coronary, aortic arch and carotid calcification; The Rotterdam Study. Journal of Human Hypertension, 24(2), 86-92. Oei, E.H.G., Koster, I.M., Hensen, JHJ, Boks, S.S., Wagemakers, H.P.A., Koes, B.W., Vroegindeweij, D., Bierma-Zeinstra, S.M.A. & Hunink, M.G.M. (2010). MRI follow-up of conservatively treated meniscal knee lesions in general practice. European Radiology, 20(5), 1242-1250. Palomaki, GE, Melillo, S, Neveux, L, Douglas, MP, Dotson, WD, Janssens, A.C.J.W., Balkite, EA & Bradley, LA (2010). Use of genomic profiling to assess risk for cardiovascular disease and identify individualized prevention strategies-a targeted evidencebased review. Genetics in Medicine, 12(12), 772-784. Pardo Silva, M.C., Njajou, OT, Alizadeh, B.Z., Hofman, A., Witteman, J.C.M., Duijn, C.M. van & Janssens, A.C.J.W. (2010). HFE gene mutations increase the risk of coronary heart disease in women. European Journal of Epidemiology, 25(9), 643-649. Peters, BJM, Rodin, AS, Klungel, O.H., Duijn, C.M. van, Stricker, B.H.C., Slot, R van 't, Boer, A. den & Zee, A.H. (2010). Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction. Pharmacogenomics, 11(8), 1065-1076. Pfeufer, A, Noord, C. van, Marciante, KD, Arking, DE, Larson, MG, Smith, AV, Tarasov, KV, Muller, M., Sotoodehnia, N, Sinner, MF, Verwoert, G.C., Li, M., Kao, WHL, Kottgen, A, Coresh, J, Bis, JC, Psaty, B.M., Rice, K, Rotter, JI, Rivadeneira, F., Hofman, A., Kors, J.A., Stricker, B.H.C., Uitterlinden, A.G., Duijn, C.M. van, Beckmann, BM, Sauter, W, Gieger, C, Lubitz, SA, Newton- Cheh, C, Wang, T.J., Magnani, JW, Schnabel, RB, Chung, MK, Barnard, J, Smith, JD, Wagoner, DR Van, Vasan, RS, Aspelund, T, Eiriksdottir, G, Harris, T.B., Launer, L.J., Najjar, SS, Lakatta, E, Schlessinger, D, Uda, M, Abecasis, GR, Muller- Myhsok, B, Ehret, GB, Boerwinkle, E., Chakravarti, A, Soliman, EZ, Lunetta, KL, Perz, S, Wichmann, HE, Meitinger, T, Levy, D., Gudnason, V, Ellinor, PT, Sanna, S, Kaab, S, Witteman, J.C.M., Alonso, A., Benjamin, EJ & Heckbert, SR (2010). Genome-wide association study of PR interval. Nature Genetics, 42(2), 153-U89. Rodenburg, E.M., Visser, L.E., Danser, A.H.J., Hofman, A., Noord, C. van, Witteman, J.C.M., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Genetic variance in CYP2C8 and increased risk of myocardial infarction. Pharmacogenetics Genomics, 20(7), 426-434. Ruiter, R. de, Visser, L.E., Eijgelsheim, M., Rodenburg, E.M., Hofman, A., Coebergh, J.W.W., Nijsten, T.E.C. & Stricker, B.H.C. (2010). High-ceiling diuretics are associated with an increased risk of basal cell carcinoma in a population-based follow-up study. European Journal of Cancer, 46(13), 2467-2472. Sardanelli, F, Hunink, M.G.M., Gilbert, FJ, Leo, G. & Krestin, G.P. (2010). Evidence-based radiology: why and how? European Radiology, 20(1), 1-15. Schuur, M., Henneman, P., Swieten, J.C. van, Zillikens, M.C., Koning, I. de, Janssens, A.C.J.W., Witteman, J.C.M., Aulchenko, Y.S., Frants, R.R., Oostra, B.A., Dijk, KW van & Duijn, C.M. van (2010). Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study. European Journal of Epidemiology, 25(8), 561-568. Seshadri, S, Fitzpatrick, AL, Ikram, M.A., DeStefano, AL, Gudnason, V, Boada, M, Bis, JC, Smith, AV, Carassquillo, MM, Lambert, JC, Harold, D, Schrijvers, E.M.C., Ramirez-Lorca, R, Debette, S, Longstreth, W.T., Janssens, A.C.J.W., Pankratz, VS, Dartigues, J.F., Hollingworth, P, Aspelund, T, Hernandez, I, Beiser, A, Kuller, LH, Koudstaal, P.J., Dickson, DW, Tzourio, C., Abraham, R, Antunez, C, Du, YC, Rotter, JI, Aulchenko, Y.S., Harris, T.B., Petersen, R.C., Berr, C, Owen, M.J., Lopez-Arrieta, 245

J, Varadarajan, BN, Becker, JT, Rivadeneira, F., Nalls, MA, Graff-Radford, NR, Campion, D, Auerbach, S, Rice, K, Hofman, A., Jonsson, PV, Schmidt, H., Lathrop, M, Mosley, TH, Psaty, B.M., Uitterlinden, A.G., Farrer, L.A., Lumley, T, Ruiz, A., Williams, J., Amouyel, P, Younkin, SG, Wolf, PA, Launer, L.J., Lopez, OL, Duijn, C.M. van & Breteler, M.M.B. (2010). Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease. Jama - Journal of the American Medical Association, 303(18), 1832-1840. Siemes, C., Visser, L.E., Jong, F.H. de, Coebergh, J.W.W., Uitterlinden, A.G., Hofman, A., Stricker, B.H.C. & Schaik, R.H.N. van (2010). Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer-the Rotterdam Study. Steroids, 75(12), 1024-1032. Smith, NL, Felix, J.F., Morrison, AC, Demissie, S, Glazer, NL, Loehr, LR, Cupples, L.A., Dehghan, A., Lumley, T, Rosamond, WD, Lieb, W, Rivadeneira, F., Bis, JC, Folsom, A.R., Benjamin, E, Aulchenko, Y.S., Haritunians, T, Couper, D, Murabito, J, Wang, YA, Stricker, B.H.C., Gottdiener, JS, Chang, PP, Wang, T.J., Rice, KM, Hofman, A., Heckbert, SR, Fox, ER, O'Donnell, CJ, Uitterlinden, A.G., Rotter, JI, Willerson, J.T., Levy, D., Duijn, C.M. van, Psaty, B.M., Witteman, J.C.M., Boerwinkle, E. & Vasan, RS (2010). Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Circulation-cardiovascular genetics, 3(3), 256-U79. Smits, M., Dippel, D.W.J., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Rijssel, DA van, Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2010). Minor Head Injury: CT-based Strategies for Management - A Cost-effectiveness Analysis. Radiology, 254(2), 532-540. Stam, AH, Vries, B de, Janssens, A.C.J.W., Vanmolkot, KRJ, Aulchenko, Y.S., Henneman, P., Oostra, B.A., Frants, R.R., Maagdenberg, A.M.J.M., Ferrari, M.D., Duijn, C.M. van & Terwindt, G.M. (2010). Shared genetic factors in migraine and depression Evidence from a genetic isolate Evidence from a genetic isolate. Neurology, 74(4), 288-294. Stricker, B.H.C. & Stijnen, T. (2010). Analysis of individual drug use as a time-varying determinant of exposure in prospective population-based cohort studies. European Journal of Epidemiology, 25(4), 245-251. Teichert, M., Visser, L.E., Dufour, M, Rodenburg, E, Straus, S.M.J.M., Smet, P.A.G.M. de & Stricker, B.H.C. (2010). Isotretinoin Use and Compliance with the Dutch Pregnancy Prevention Programme A Retrospective Cohort Study in Females of Reproductive Age Using Pharmacy Dispensing Data. Drug Safety, 33(4), 315-326. Terracciano, A, Sanna, S, Uda, M, Deiana, B, Usala, G, Busonero, F, Maschio, A. del, Scally, M, Patriciu, N, Chen, WM, Distel, MA, Slagboom, E.P., Boomsma, D.I., Villafuerte, S, Sliwerska, E, Burmeister, M, Amin, N., Janssens, A.C.J.W., Duijn, C.M. van, Schlessinger, D, Abecasis, GR & Costa, PT (2010). Genome-wide association scan for five major dimensions of personality. Molecular Psychiatry, 15(6), 647-656. Theuns, D.A.M.J., Smith, T., Hunink, M.G.M., Bardy, GH & Jordaens, L.J.L.M. (2010). Effectiveness of prophylactic implantation of cardioverter-defibrillators without cardiac resynchronization therapy in patients with ischaemic or non-ischaemic heart disease: a systematic review and meta-analysis. Europace, 12(11), 1564-1570. 246

EMC NIHES-01-66-01 Biostatistics Programme in brief design This program comprises two parts: general medical statistics and genetic statistics. The activities of the general medical statistics group are research in biostatistics on topics such as statistical modeling of complex data structures, clinical trial methodology, Bayesian methods, meta-analyses, smoothing approaches, survival analysis, etc. Monthly seminars, working groups on specific methodological topics, two courses/year and a yearly symposium are activities of the group to promote statistical research together with quantitative researchers from the whole of Erasmus MC, but also to make publicity for the department outside Erasmus University. Further, the group provides statistical consultancy to and collaborates with various clinical departments and the department of epidemiology. There is also a strong participation of the group in the Nihes and Erasmus Winter and Summer teaching programs. In addition, the activities on genetic statistics concentrate on high-throughput methods: microarrays, SNPs, proteomics and metabolomics. Of special interest is also the cooperation with the Bioinformatics Department, to integrate data bases, friendly interfaces and standard tools for data visualization with existing and newly developed statistical methods. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot Biostatistics 3,52 0 0 1,25 4,77 gastroenterology & hepatology 0,3 0 0 0 0,3 Total 3,82 0 0 1,25 5,07 0 0 0 0 90 6 0 96 Artikel/Letter to the editor Bali, E, Feron, E.J., Peperkamp, E., Veckeneer, M., Mulder, P.G.H. & Meurs, J.C. van (2010). The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial. Graefes Archive for Clinical and Experimental Ophthalmology, 248(7), 957-962. Berg, I. van den, Arends, L.R. & Duvekot, J.J. (2010). Correction of nonvertex presentation with moxibustion (vol 201, pg 241, 2009). American Journal of Obstetrics and Gynecology, 203(2), E15-E16. Berg, I. van den, Kaandorp, G.C., Bosch, J.L., Duvekot, J.J., Arends, L.R. & Hunink, M.G.M. (2010). Cost-effectiveness of breech version by acupuncture-type interventions on BL 67, including moxibustion, for women with a breech foetus at 33 weeks gestation: a modelling approach. Complementary Therapies in Medicine, 18(2), 67-77. Berg, L.E.M. van den, Zandbergen, A.A.M., Capelle, C.I. van, Vries, J.M. de, Hop, W.C.J., Hout, J.M.P. van den, Reuser, A.J.J., Zillikens, M.C. & Ploeg, A.T. van der (2010). Low bone mass in Pompe disease. Muscular strength as a predictor of bone mineral density. Bone, 47, 649-7. Birkenhager, T.K., Pluijms, E.M., Ju, M.R., Mulder, P.G.H. & Broek, W.W. van den (2010). Influence of age on the efficacy of electroconvulsive therapy in major depression: A retrospective study. Journal of Affective Disorders, 126(1-2), 257-261. Bloemberg, TG, Gerretzen, J, Wouters, HJP, Gloerich, J, Dael, M van, Wessels, HJCT, Heuvel, L.P. van den, Eilers, P.H.C., Buydens, LMC & Wehrens, R (2010). Improved parametric time warping for proteomics. Chemometrics & Intelligent Laboratory Systems, 104(1), 65-74. Boer, D.P., Rijke, Y.B. de, Hop, W.C.J., Cransberg, K. & Dorresteijn, E.M. (2010). Reference values for serum creatinine in children younger than 1 year of age. Pediatric Nephrology, 25, 2107-2113. Boot, A.M., Ridder, M.A.J. de, Sluis, I.M. van der, Slobbe, I.M. van, Krenning, E.P. & Muinck Keizer-Schrama, S.M.P.F. (2010). Peak bone mineral density, lean body mass and fractures. Bone, 46(2), 336-341. Buysse, C.M.P., Vermunt, L.C.A.C., Raat, H., Hazelzet, J.A., Hop, W.C.J., Utens, E.M.W.J. & Joosten, K.F.M. (2010). Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life. Critical Care, 14(3), 124. Capelle, C.I. van, Beek, N.A.M.E. van der, Hagemans, M.L.C., Arts, W.F.M., Hop, W.C.J., Lee, P., Jaeken, J., Frohn-Mulder, I.M.E., Merkus, P.J.F.M., Corzo, D, Puga, A.C., Reuser, A.J.J. & Ploeg, A.T. van der (2010). Effect of enzyme therapy in juvenile patients with Pompe disease: a three-year open-label study. Neuromuscular Disorders, 20, 775-782. Dejardin, D, Lesaffre, E.M.E.H. & Verbeke, G. (2010). Joint modeling of progression-free survival and death in advanced cancer clinical trials. Statistics in Medicine, 29(16), 1724-1734. Diya, L, Lesaffre, E.M.E.H., Heede, K, Sermeus, W & Vleugels, A. (2010). Establishing the relationship between nurse staffing and hospital mortality using a clustered discrete-time model. Statistics in Medicine, 29, 778-785. Eijk, R. van, Eilers, P.H.C., Natte, R, Cleton-Jansen, AM, Morreau, H., Wezel, T van & Oosting, J. (2010). MLPAinter for MLPA interpretation: an integrated approach for the analysis, visualisation and data management of Multiplex Ligation-dependent Probe Amplification. Bmc Bioinformatics, 11. Garcia-Zattera, MJ, Mutsvari, T, Jara, A, Declerck, D & Lesaffre, E.M.E.H. (2010). Correcting for misclassification for a monotone disease process with an application in dental research. Statistics in Medicine, 29, 3103-3117. 247

Geelhoed, J.J.M., Taal, H.R., Steegers, E.A., Arends, L.R., Lequin, M., Moll, H.A., Hofman, A., Heijden, A.J. van der & Jaddoe, V.W.V.K. (2010). Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Pediatric Nephrology, 25(2), 289-298. Geijn, F.E. van de, Man, Y.A. de, Wuhrer, M, Willemsen, S.P., Deelder, A.M., Hazes, J.M.W. & Dolhain, R.J.E.M. (2010). CAN MANNOSE- BINDING LECTIN EXPLAIN THE COURSE AND OUTCOME OF PREGNANCY IN RHEUMATOID ARTHRITIS? Annals of the Rheumatic Diseases, 69, A107. Ghidey, W, Lesaffre, E.M.E.H. & Verbeke, G. (2010). A comparison of methods for estimating the random effects distribution of a linear mixed model A comparison of methods for estimating the random effects distribution of a linear mixed model. Statistical Methods in Medical Research, 19(6), 575-600. Grootenboer, N., Sambeek, M.R.H.M. van, Arends, L.R., Hendriks, J.M., Hunink, M.G.M. & Bosch, J.L. (2010). Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm. British Journal of Surgery, 97(8), 1169-1179. Hagemans, M.L.C., Stigter, R.L., Capelle, C.I. van, Beek, N.A.M.E. van der, Winkel, L.P.F., Vliet, L. van, Hop, W.C.J., Reuser, A.J.J., Beishuizen, A. & Ploeg, A.T. van der (2010). PAS-positive lymphocyte vacuoles can be used as diagnostic screening test for Pompe disease. Journal of Inherited Metabolic Disease, 33, 133-139. Hamberg, A.P., Ratain, MJ, Lesaffre, E.M.E.H. & Verweij, J. (2010). Dose-escalation models for combination phase I trials in oncology. European Journal of Cancer, 46(16), 2870-2878. Hansen, B.E., Buster, E.H.C.J., Steyerberg, E.W., Lesaffre, E.M.E.H. & Janssen, H.L.A. (2010). Prediction of the Response to Peg-Interferon-Alfa in Patients With HBeAg Positive Chronic Hepatitis B Using Decline of HBV DNA During Treatment. Journal of Medical Virology, 82(7), 1135-1142. Heede, K, Simoens, S, Diya, L, Lesaffre, E.M.E.H., Vleugels, A. & Sermeus, W (2010). Increasing nurse staffing levels in Belgian cardiac surgery centres: a cost-effective patient safety intervention? Journal of Advanced Nursing, 66(6), 1291-1296. Heijnen, W.T.C.J., Broek, W.W. van den, Mulder, P.G.H. & Birkenhager, T.K. (2010). Prevalence of trait anxiety in a sample of depressed inpatients and its influence on response to antidepressants. Journal of Psychopharmacology, 24(4), 559-563. Hout, L. van den, Reiss, I.K.M., Felix, J.F., Hop, W.C.J., Lally, K.P., Tibboel, D. & Congenital Diaphragmatic Hernis Study group, - (2010). Risk factors for chronic lung disease and mortality in newborns with congenital diaphragmatic hernia. Neonatology, 98, 370-380. Hulst, J.M., Zwart, H., Hop, W.C.J. & Joosten, K.F.M. (2010). Dutch national survey to test the STRONGkids nutritional risk screening tool in hospitalized children. Clinical Nutrition, 29, 106-111. Hunfeld, N.G.M., Touw, D.J., Mathot, R.A.A., Mulder, P.G.H., Schaik, R.H.N. van, Kuipers, E.J., Kooiman, J.C. & Geus, W.P. (2010). A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism. Alimentary Pharmacology & Therapeutics, 31, 150-159. Jansen, T.C., Bommel, J. van, Schoonderbeek, F.J., Visser, SJS, Klooster, JM van der, Lima, A.P. de, Willemsen, S.P. & Bakker, J. (2010). Early Lactate-Guided Therapy in Intensive Care Unit Patients A Multicenter, Open-Label, Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine, 182(6), 752-761. Jara, A, Lesaffre, E.M.E.H., Oiro, M. De & Quintana, F (2010). Bayesian semiparametric inference for multivariate doubly interval-censored data. Annals of Applied Statistics, 4, 2126-2149. Jong, E.M. de, Haan, M.A.M. de, Gischler, S.J., Hop, W.C.J., Overbeek, T.E., Bax, N.M.A., Klein, A. de, Tibboel, D. & Grijseels, E.W.M. (2010). Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistula. Prenatal Diagnosis, 30(3), 274-279. Jong, J.C. de, Escher, J.C., Arends, L.R., Jaddoe, V.W.V.K., Hofman, A., Raat, H. & Moll, H.A. (2010). Infant nutritional factors and functional constipation in childhood: The Generation R Study. American Journal of Gastroenterology, 105, 940-945. Joosten, K.F.M., Zwart, H., Hop, W.C.J. & Hulst, J.M. (2010). National malnutrition screening days in hospitalised children in The Netherlands. Archives of Disease in Childhood, 95, 141-145. Joosten, K.F.M., Zwart, H., Hop, W.C.J. & Hulst, J.M. (2010). Ondervoeding bij eenvijfde van kinderen opgenomen in Nederlandse ziekenhuizen. Nederlands Tijdschrift voor Geneeskunde, 154, A1641. Kaay, D.C.M. van der, Bakker, B., Hulst, F van der, Mul, D., Mulder, J, Schroor, E, Elswijk, D van, Rowaan, I, Willeboer, M, Ridder, M.A.J. de & Hokken-Koelega, A.C.S. (2010). Randomized GH trial with two different dosages in combination with a GnRH analogue in short small for gestational age children: effects on metabolic profile and serum GH, IGF1, and IGFBP3 levels. European Journal of Endocrinology, 162(5), 887-895. Kalmijn, W.M. & Arends, L.R. (2010). Measures of Inequality: Application to Happiness in Nations. Social Indicators Research, 99(1), 147-162. Kekelidze, M., Dwarkasing, R.S., Dijkshoorn, M.L., Sikorska, K., Verhagen, P.C.M.S. & Krestin, G.P. (2010). Kidney and Urinary Tract Imaging: Triple-Bolus Multidetector CT Urography as a One-Stop Shop-Protocol Design, Opacification, and Image Quality Analysis. Radiology, 255(2), 508-516. 248

Kharagjitsingh, AV, Ridder, M.A.J. de, Roep, B.O., Koeleman, B.P.C., Bruining, G.J. & Veeze, H.J. (2010). Revisiting infant growth prior to childhood onset type 1 diabetes. Clinical Endocrinology, 72(5), 620-624. Komarek, A, Hansen, B.E., Kuipers, E.J., Buuren, H.R. van & Lesaffre, E.M.E.H. (2010). Discriminant analysis using a multivariate linear mixed model with a normal mixture in the random effects distribution. Statistics in Medicine, 29, 3267-3283. Kroep, JR, Linn, SC, Boven, E., Bloemendal, HJ, Baas, J, Mandjes, IAM, Bosch, J.L., Smit, WM, Graaf, H. de, Schroder, CP, Vermeulen, G.J., Hop, W.C.J. & Nortier, J.W.R. (2010). Lapatinib: clinical benefit in patients with HER2-positive advanced breast cancer. Netherlands Journal of Medicine, 68(9), 371-376. Kuiper, E.M.M., Erpedum, KJ van, Beuers, U, Hansen, B.E., Thio, H.B., Man, R.A. de, Janssen, H.L.A. & Buuren, H.R. van (2010). The Potent Bile Acid Sequestrant Colesevelam Is Not Effective in Cholestatic Pruritus: Results of a Double-Blind, Randomized, Placebo-Controlled Trial. Hepatology, 52(4), 1334-1340. Kuiper, E.M.M., Hansen, B.E., Metselaar, H.J., Man, R.A. de, Haagsma, E.B., Hoek, B. van & Buuren, H.R. van (2010). Trends in liver transplantation for primary biliary cirrhosis in the Netherlands 1988-2008. BMC Gastroenterology, 10, 144. Kuitwaard, K., Berg, L.H. van den, Vermeulen, M., Brusse, E., Cats, E.A., Kooi, A.J. van der, Notermans, N.C., Pol, WL van der, Schaik, IN van, Nes, S.I. van, Hop, W.C.J. & Doorn, P.A. van (2010). Randomised controlled trial comparing two different intravenous immunoglobulins in chronic inflammatory demyelinating polyradiculoneuropathy. Journal of Neurology Neurosurgery and Psychiatry, 81(12), 1374-1379. Lem, A.J., Kort, S.W.K. de, Ridder, M.A.J. de & Hokken-Koelega, A.C.S. (2010). Should short children born small for gestational age with a distance to target height <1 standard deviation score be excluded form growth hormone treatment? Clinical Endocrinology, 73, 355-360. Marx, BD, Eilers, P.H.C., Gampe, J & Rau, R (2010). Bilinear modulation models for seasonal tables of counts. Statistics and Computing, 20(2), 191-202. Menke, L.A., Sas, T.C.J., Muinck Keizer-Schrama, S.M.P.F., Zandwijken, G.R.J., Ridder, M.A.J. de, Odink, RJ, Jansen, M., Delamarre- van de Waal, H.A., Stokvis-Brantsma, W.H., Waelkens, J., Westerlaken, C., Reeser, H.M., Trotsenburg, A.S.P. van, Gevers, E., Buuren, S. van, Dejonckere, P.H.O., Hokken-Koelega, A.C.S., Otten, B.J. & Wit, J.M. (2010). Efficacy and safety of Oxandrolone in growth hormone-treated girls with Turner Syndrome. Journal of Clinical Endocrinology and Metabolism, 95(3), 1151-1160. Menke, L.A., Sas, T.C.J., Zandwijken, G.R.J., Ridder, M.A.J. de, Stijnen, Th., Muinck Keizer-Schrama, S.M.P.F., Otten, B.J. & Wit, J.M. (2010). The effect of oxandrolone on body proportions and body composition in growth hormone-treated girls with Turner syndrome. Clinical Endocrinology, 73, 212-219. Molas, M.A. & Lesaffre, E.M.E.H. (2010). Hurdle models for multilevel zero-inflated data via H-likelihood. Statistics in Medicine, 29, 3294-3310. Molenaar, H.M., Selles, R.W., Zuidam, J.M., Willemsen, S.P., Stam, H.J. & Hovius, S.E.R. (2010). Growth Diagrams for Grip Strength in Children. Clinical Orthopaedics & Related Research, 468(1), 217-223. Mook-Kanamori, D.O., Steegers, E.A.P., Eilers, PH, Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Risk Factors and Outcomes Associated With First-Trimester Fetal Growth Restriction. Jama - Journal of the American Medical Association, 303(6), 527-534. Mook-Kanamori, D.O., Steegers, E.A.P., Eilers, P.H.C., Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Risk Factors and Outcomes Associated With First-Trimester Fetal Growth Restriction. Obstetrical and Gynecological Survey, 65(6), 362-363. Morak, M.J.M., Pek, C.J., Kompanje, E.J.O., Hop, W.C.J., Kazemier, G. & Eijck, C.H.J. van (2010). Quality of Life After Adjuvant Intra-Arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer A Prospective Randomized Controlled Study. Cancer, 116(4), 830-836. Mutsvari, T, Lesaffre, E.M.E.H., Garcia-Zattera, MJ, Diya, L & Declerck, D (2010). Factors That Influence Data Quality in Caries Experience Detection: A Multilevel Modeling Approach. Caries Research, 44(5), 438-444. Nout, E., Bouw, F.P., Veenland, J.F., Hop, W.C.J., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2010). Three- Dimensional Airway Changes after Le Fort III Advancement in Syndromic Craniosynostosis Patients. Plastic and Reconstructive Surgery, 126(2), 564-571. Obermann-Borst, S.A., Heijmans, B.T., Slagboom, E.P., Eilers, P.H.C., Wildhagen, M.F., Steegers, E.A.P. & Steegers- Theunissen, R.P.M. (2010). Periconception Maternal Risk Factors Affect DNA Methylation Profiles in Very Young Children, with Gender Effects. Reproductive Sciences, 17(3), 223A-223A. Oirbeek, R. van & Lesaffre, E.M.E.H. (2010). An application of Harrell's C-index to PH frailty models. Statistics in Medicine, 3160-3171. Overbeek, T.E., Tong, W.H., Hatzmann, T.R., Wilms, J.F., Govaerts, L.C.P., Galjaard, R.J.H., Steegers, E.A.P., Hop, W.C.J., Wladimiroff, J.W. & Tibboel, D. (2010). Omphalocele: comparison of outcome following prenatal or postnatal diagnosis. Ultrasound in Obstetrics & Gynecology, 36, 687-692. Perperoglou, A & Eilers, P.H.C. (2010). Penalized regression with individual deviance effects. Computational Statistics, 25(2), 341-361. 249

Plaisier, A., Maingay - de Groof, F, Mast-Harwig, R, Kalkman, P.M.J., Wulkan, R.W., Verwers, R, Neele, M, Hop, W.C.J. & Groeneweg, M. (2010). Plasma water as a diagnostic tool in the assessment of dehydration in children with acute gastroenteritis. European Journal of Pediatrics, 169(7), 883-886. Ramlal, SK, Visser, FJ, Hop, W.C., Dekhuijzen, P.N.R. & Heijdra, YF (2010). Reversibility of inspiratory lung function parameters after short-term bronchodilators in COPD. Respiratory Physiology & Neurobiology, 173(1), 58-63. Ramshorst, G.H. van, Nieuwenhuizen, J., Hop, W.C.J., Arends, P., Boom, J., Jeekel, J. & Lange, J.F. (2010). Abdominal Wound Dehiscence in Adults: Development and Validation of a Risk Model. World Journal of Surgery, 34(1), 20-27. Reijnders, J.G.P., Deterding, K, Petersen, J, Zoulim, F, Santantonio, T, Buti, M, Bommel, F van, Hansen, B.E., Wedemeyer, H & Janssen, H.L.A. (2010). Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues. Journal of Hepatology, 52(4), 493-500. Reijnders, J.G.P., Perquin, M.J., Zhang, N., Hansen, B.E. & Janssen, H.L.A. (2010). Nucleos(t)ide Analogues Only Induce Temporary Hepatitis B e Antigen Seroconversion in Most Patients With Chronic Hepatitis B. Gastroenterology, 139(2), 491-498. Rijckborst, V., Borg, M.J. ter, Cakaloglu, Y, Ferenci, P, Tabak, F, Akdogan, M, Simon, K, Raptopoulou-Gigi, M, Ormeci, N, Zondervan, P.E., Hart, E., Vuuren, A.J. van, Hansen, B.E. & Janssen, H.L.A. (2010). A Randomized Trial of Peginterferon alpha-2a With or Without Ribavirin for HBeAg-Negative Chronic Hepatitis B. American Journal of Gastroenterology, 105(8), 1762-1769. Rijckborst, V., Hansen, B.E., Cakaloglu, Y, Ferenci, P, Tabak, F, Akdogan, M, Simon, K, Akarca, US, Flisiak, R, Hart, E., Vuuren, A.J. van, Boucher, C.A.B., Borg, M.J. ter & Janssen, H.L.A. (2010). Early On-Treatment Prediction of Response to Peginterferon Alfa-2a for HBeAg-Negative Chronic Hepatitis B Using HBsAg and HBV DNA Levels. Hepatology, 52(2), 454-461. Rizopoulos, D. (2010). JM: An R Package for the Joint Modelling of Longitudinal and Time-to-Event Data. Journal of Statistical Software, 35(9), 1-33. Rizopoulos, D., Verbeke, G. & Molenberghs, G. (2010). Multiple-Imputation-Based Residuals and Diagnostic Plots for Joint Models of Longitudinal and Survival Outcomes. Biometrics, 66(1), 20-29. Roomer, R., Hansen, B.E., Janssen, H.L.A. & Knegt, R.J. de (2010). Risk Factors for Infection During Treatment with Peginterferon alfa and Ribavirin for Chronic Hepatitis C. Hepatology, 52(4), 1225-1231. Roomer, R., Hansen, B.E., Janssen, H.L.A. & Knegt, R.J. de (2010). Thrombocytopenia and the risk of bleeding during treatment with peginterferon alfa and ribavirin for chronic hepatitis C. Journal of Hepatology, 53(3), 455-459. Rousian, M., Koning, A.H.J., Oppenraaij, R.H.F. van, Hop, W.C.J., Verwoerd-Dikkeboom, C.M., Spek, P.J. van der, Exalto, N. & Steegers, E.A.P. (2010). An innovative virtual reality technique for automated human embryonic volume measurements. Human Reproduction, 25(9), 2210-2216. Ruts, L., Drenthen, J., Jongen, J.L.M., Hop, W.C.J., Visser, G.H., Jacobs, B.C. & Doorn, P.A. van (2010). Pain in Guillain-Barre syndrome A long-term follow-up study. Neurology, 75(16), 1439-1447. Sant, H.P. van t, Weidema, W.F., Hop, W.C.J., Oostvogel, HJM & Contant, C.M.E. (2010). The Influence of Mechanical Bowel Preparation in Elective Lower Colorectal Surgery. Annals of Surgery, 251(1), 59-63. Sas, T.C.J., Ridder, M.A.J. de, Wit, J.M., Rotteveel, J, oostdijk, W., Reeser, H.M., Otten, B.J. & Muinck Keizer-Schrama, S.M.P.F. (2010). Adult height in children with growth hormone deficiency: a randomized, controlled, growth hormone doseresponse trial. HORMONE RESEARCH IN PAEDIATRICS, 74, 172-181. Sonneveld, M.J., Rijckborst, V., Boucher, C.A.B., Hansen, B.E. & Janssen, H.L.A. (2010). Prediction of Sustained Response to Peginterferon Alfa-2b for Hepatitis B e Antigen Positive Chronic Hepatitis B Using On-Treatment Hepatitis B Surface Antigen Decline. Hepatology, 52(4), 1251-1257. Spaander, V.M.C.W., Buuren, H.R. van, Hansen, B.E. & Janssen, H.L.A. (2010). Ascites in patients with noncirrhotic nonmalignant extrahepatic portal vein thrombosis. Alimentary Pharmacology & Therapeutics, 32(4), 529-534. Speksnijder, L., Rutten, J.H.W., Meiracker, A.H. van den, Bruin, R.J.A. de, Lindemans, J., Hop, W.C.J. & Visser, W.E. (2010). Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a biomarker of cardiac filling pressures in pre-eclampsia. European Journal of Obstetrics, Gynecology and Reproductive Biology, 153(1), 12-15. Sprenger, H.G., Langebeek, N, Mulder, P.G.H., Napel, CHH Ten, Vriesendorp, R., Hoepelman, A.I.M., Legrand, JC, Koopmans, P.P., Kasteren, M.E.E. van, Bravenboer, B, Kate, RW Ten, Groeneveld, P.H.P., Werf, TS Van der, Gisolf, E.H. & Richter, C. (2010). Abacavir/Lamivudine/Zidovudine Maintenance After Standard Induction in Antiretroviral Therapy-Naive Patients: FREE Randomized Trial Interim Results. Aids Patient Care and Stds, 24(6), 361-366. Stocker, M., Hop, W.C.J. & Rossum, A.M.C. van (2010). Neonetal Procalcitonin Intervention Study (NeoPInS): Effect of Procalcitonin-guided decision making on duration of antibiotic therapy in suspected neonatal early-onset sepsis: a multicentre randomized superiority and non-inferiority intervention study. BMC Pediatrics, 10, 89. Tjon, S.W.A., Sint Nicolaas, J., Kwekkeboom, J., Man, R.A. de, Kazemier, G., Tilanus, H.W., Hansen, B.E., Laan, L.J.W. van der, Tha-In, T.H. & Metselaar, H.J. (2010). Increased Incidence of Early De Novo Cancer in Liver Graft Recipients Treated with Cyclosporine: An Association with C-2 Monitoring and Recipient Age. Liver Transplantation, 16(7), 837-846. 250

Truyers, C, Lesaffre, E.M.E.H., Bartholomeeusen, S, Aertgeerts, B, Snacken, R., Brochier, B, Yane, F & Buntinx, F (2010). Computerized general practice based networks yield comparable performance with sentinel data in monitoring epidemiological time-course of influenza-like illness and acute respiratory illness. BMC Family Practice, 11. Truyers, C, Lesaffre, E.M.E.H., Kellen, E, Bartholomeeusen, S, Aertgeerts, B & Buntinx, F (2010). Malignant melanoma: to screen or not to screen? An evaluation of the Euromelanoma Day in Belgium. European Journal of Dermatology, 20(4), 517-518. Tsonaka, R, Rizopoulos, D., Verbeke, G. & Lesaffre, E.M.E.H. (2010). Nonignorable Models for Intermittently Missing Categorical Longitudinal Responses. Biometrics, 66(3), 834-844. Uijen, J.H.J.M., Schellevis, F.G., Bindels, P.J.E., Willemsen, S.P. & Wouden, J.C. v.d. (2010). Low hospital admission rates for respiratory diseases in children. BMC Family Practice, 11. Vaessen-Verberne, AAPH, Berg, NJ van den, Nierop, J.C. van, Brackel, H.J.L., Gerrits, G.P.J.M., Hop, W.C.J. & Duiverman, E.J. (2010). Combination Therapy Salmeterol/Fluticasone Versus Doubling Dose of Fluticasone in Children With Asthma. American Journal of Respiratory and Critical Care Medicine, 182(10), 1221-1227. Vanhaecht, K, Bellemans, J, Witte, K. de, Diya, L, Lesaffre, E.M.E.H. & Sermeus, W (2010). Does the organization of care processes affect outcomes in patients undergoing total joint replacement? Journal of Evaluation in Clinical Practice, 16(1), 121-128. Vanwolleghem, T., Libbrecht, L, Hansen, B.E., Desombere, I, Roskams, T, Meuleman, P & Leroux-Roels, G. (2010). Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in upa-scid mice. Journal of Hepatology, 53(3), 468-476. Velden, V.H.J. van der, Sluijs-Geling, A van der, Gibson, BES, Marvelde, J.G. te, Hoogeveen, P.G., Hop, W.C.J., Wheatley, K., Bierings, M.B., Schuurhuis, G.J., Graaf, S.S.N. de, Wering, E.R. van & Dongen, J.J.M. van (2010). Clinical significance of flowcytometric minimal residual disease detection in pediatric acute myeloid leukemia patients treated according to the DCOG ANLL97/MRC AML12 protocol. Leukemia, 24(9), 1599-1606. Verdijk, R.M., Bakker, M.A. den, Dubbink, H.J., Hop, W.C.J., Dinjens, W.N.M. & Kros, J.M. (2010). TP53 Mutation Analysis of Malignant Peripheral Nerve Sheath Tumors. Journal of Neuropathology and Experimental Neurology, 69(1), 16-26. Verhagen, A.P., Schoonloo-Karels, C.H., Schellingerhout, J.M., Willemsen, S.P., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2010). Pain severity and catastrophising modify treatment success in neck pain patients in primary care. Manual Therapy, 15(3), 267-272. Vermeiden, M., Broek, W.W. van den, Mulder, P.G.H. & Birkenhager, T.K. (2010). Influence of gender and menopausal status on antidepressant treatment response in depressed inpatients. Journal of Psychopharmacology, 24(4), 497-502. Verwoerd-Dikkeboom, C.M., Koning, A.H.J., Hop, W.C.J., Spek, P.J. van der, Exalto, N. & Steegers, E.A.P. (2010). Innovative virtual reality measurements for embryonic growth and development. Human Reproduction, 25(6), 1404-1410. Veugelers, R., Benninga, M.A., Calis, E.A.C., Willemsen, S.P., Evenhuis, H.M., Tibboel, D. & Penning, C. (2010). Prevalence and clinical presentation of constipation in children with severe generalized cerebral palsy. Developmental Medicine & Child Neurology, 52(9), E216-E221. Vries - Sluijs, T.E.M.S. de, Reijnders, J.G.P., Hansen, B.E., Zaaijer, H.L, Prins, J.M., Pas, S.D., Schutten, M., Hoepelman, A.I.M., Richter, C., Mulder, J.W., Man, R.A. de, Janssen, H.L.A. & Ende, M.E. van der (2010). Long-term Therapy With Tenofovir Is Effective for Patients Co-Infected With Human Immunodeficiency Virus and Hepatitis B Virus. Gastroenterology, 139(6), 1934-1941. Winkel, M.L. te, Beek, R.D. van, Muinck Keizer-Schrama, S.M.P.F., Uitterlinden, A.G., Hop, W.C.J., Pieters, R. & Heuvel- Eibrink, M.M. van den (2010). Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia. Haematologica, 95(5), 752-758. Zee, J.A. van der, Hagen, T.L.M. ten, Hop, W.C.J., Dekken, H. van, Dicheva, B.M., Seynhaeve, A.L.B., Koning, G.A., Eggermont, A.M.M. & Eijck, C.H.J. van (2010). Differential expression and prognostic value of HMGA1 in pancreatic head and periampullary cancer. European Journal of Cancer, 46(18), 3393-3399. Zijp, M.H.M. van, Meijers-IJsselstijn, H., Takken, T., Willemsen, S.P., Tibboel, D., Stam, H.J. & Berg-Emons, H.J.G. van den (2010). Exercise testing of pre-school children using the Bruce treadmill protocol: new reference values. European Journal of Applied Physiology, 108(2), 393-399. Part of book - abstract Commandeur, J. & Montfort, C.A.G.M. van (2010). State space methods for latent trajectory and parameter estimation. In K. van Montfort, J. Oud & A Satorra (Eds.), Longitudinal research with latent variables (pp. 177-200). Dordrecht: Springer Verlag. Verbeke, G., Molenberghs, G. & Rizopoulos, D. (2010). Random effects models for longitudinal data. In K. van Montfort, J. Oud & A Satorra (Eds.), Longitudinal research with latent variables. Dordrecht: Springer Verlag. Boekredactie Montfort, C.A.G.M. van, Oud, J.H.L. & Satorra, A (Eds.). (2010). Longitudinal research with latent variables. Dordrecht: Springer Verlag. 251

EMC NIHES-02-65-01 - Effects of screening and clinical interventions on population health Programme in brief design The research programme, originally titled Effects of interventions on population health aims to contribute to improved population health by evaluating the favourable and unfavourable effects and the cost-effectiveness of health care interventions, particularly screening for diseases and clinical interventions, and tropical disease control. Our commitment to the improvement of population health is combined with a strong emphasis on quantitative research methods, thereby maximising quality and public health impact. We conduct observational as well as experimental studies amongst other large scale RCT s on screening and often use advanced statistical methods and computer simulation models on the natural history of disease. A shared research focus includes development and application of dynamic age-structured population health models; standardization of research methodology with respect to descriptive health status measurement, development and application of statistical methods and use and optimization of micro-simulation modelling. This programme consists of 3 sections: evaluation of screening, medical decision-making, and infectious diseases control (Prof.dr. H.J. de Koning, Prof.dr. E.W. Steyerberg, Prof.dr. JH Richardus, Dr. A. van der Heide, Dr. M. van Ballegooijen) and links with the research group on cancer surveillance (Prof. dr. J.W.W. Coebergh). In evaluation of screening, three types of study are undertaken: (1) Monitoring and evaluation of ongoing screening programmes and randomised trials. (2) Prospective evaluation and prediction of screening strategies, with emphasis on impact on morbidity and mortality and on cost-effectiveness. (3) Mathematical modelling of new developments and research questions. Specific fields are cancer, cardiovascular disease, prenatal screening and child health surveillance, developmental disorders and child abuse, and genetic disorders. In evaluation of clinical care, three questions are studied: what is wrong with the patients? (diagnostics), what can be done about it? (therapy choice), and what will happen? (prognosis). Emphasis is on studying prognosis and on methodological issues, and on medical decisions concerning the end of life. In infectious disease control, research is focused on collection and analysis of empirical data, and development and application of models for the epidemiology and control of important infectious diseases of the tropical zone (onchocerciasis, lymphatic filariasis, schistosomiasis, leprosy, tuberculosis, malaria and sexually transmitted diseases), and in the Western context like Hepatitis A, B and C, and STD"s. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot public health 4,67 13,79 4,8 9,89 33,15 Total 4,67 13,79 4,8 9,89 33,15 7 1 0 8 176 9 12 205 Thesis Bergh, K.A.M. van den (2010, oktober 13). Health-related quality of life and informed decision-making in lung cancer screening. EUR (193 pag.). Prom./coprom.: Prof. Dr. H.J. de Koning, Dr. R.J. van Klaveren & dr M.L. Essink-Bot. Cao, W-C (2010, juni 02). Thickborne rickettsial diseases: epidemiological studies in China. EUR. Prom./coprom.: Prof.Dr. J.D.F. Habbema & Prof. Dr. J.H. Richardus. Fischer, E.A.J. (2010, september 03). On the spread of Leprosy in a heterogeneous population. EUR (156 pag.). Prom./coprom.: Prof.Dr. J.D.F. Habbema & Prof. Dr. J.H. Richardus. Fransen, M.P. (2010, maart 31). Ethnic differences in prenatal screening for Down syndrome: information, decision-making and participation. EUR. Prom./coprom.: Prof. Dr. J.P. Mackenbach, dr M.L. Essink-Bot & Dr. H.I.J. Wildschut. Hol, L. (2010, april 13). Population-based screening for colorectal cancer. EUR. Prom./coprom.: Prof. Dr. E.J. Kuipers, Prof.Dr. J.D.F. Habbema & Dr. M.E. van Leerdam. Lingsma, H.F. (2010, november 26). Measuring quality of care. EUR (270 pag.). Prom./coprom.: Prof. Dr. E.W. Steyerberg. Veen, M. (2010, april 16). The Manchester Triage System in paediatric emergency care. EUR (168 pag.) (Enschede: Ipskamp Drukkers). Prom./coprom.: Prof. Dr. H.A. Moll & Prof. Dr. E.W. Steyerberg. Vissers, D.C.J. (2010, februari 25). The role of mobility in HIV transmission and control. EUR. Prom./coprom.: Prof.Dr. J.D.F. Habbema & Dr. S.J. de Vlas. Artikel/Letter to the editor Aa, M.N.M. van der, Steyerberg, E.W., Bangma, C.H., Rhijn, B.W.G. van, Zwarthoff, E.C. & Kwast, T.H. van der (2010). Cystoscopy revisited as the gold standard for detecting bladder cancer recurrence: diagnostic review bias in the randomized, prospective CEFUB trial. Journal of Urology, 183(1), 76-80. Aalst, C.M. van der, Klaveren, R.J. van & Koning, H.J. de (2010). Does participation to screening unintentionally influence lifestyle behaviour and thus lifestyle-related morbidity? Best Practice & Research in Clinical Gastroenterology, 24(4), 465-478. 252

Aalst, C.M. van der, Bergh, K.A.M. van den, Willemsen, MC, Koning, H.J. de & Klaveren, R.J. van (2010). Lung cancer screening and smoking abstinence: 2 year follow-up data from the Dutch-Belgian randomised controlled lung cancer screening trial. Thorax, 65(7), 600-605. Aalst, C.M. van der (2010). Volumemeting als nieuwe strategie bij longkankerscreening. Oncologie Up-to-Date, 1(1), 10-11. Auvinen, A., Koning, H.J. de & Coebergh, J.W.W. (2010). Foreword: Meeting the challenge of prostate cancer. European Journal of Cancer, 46(17), 3037-3039. Baecke, E., Koning, H.J. de, Otto, S.J., Iersel, C.A. van & Klaveren, R.J. van (2010). Limited contamination in the Dutch-Belgian randomized lung cancer screening trial (NELSON). Lung Cancer, 69(1), 66-70. Ballegooijen, M. van, Kok, I.M.C.M. de & Habbema, J.D.F. (2010). Ongelijke discontering van zorgkosten en -effecten: verwarrend. Nederlands Tijdschrift voor Geneeskunde, 154(25), 1970. Ballegooijen, M. van, Boer, R. & Zauber, A.G. (2010). Simulation of colorectal cancer screening: What we do and do not know and does it matter. Best Practice & Research in Clinical Gastroenterology, 24(4), 427-437. Bannink, N., Maliepaard, M., Raat, H., Joosten, K.F.M. & Mathijssen, I.M.J. (2010). Health-related quality of life in children and adolescent with syndromic craniosynostosis. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63, 1972-1981. Bekker- Grob, E.W. de, Hofman, R., Donkers, B., Ballegooijen, M. van, Helmerhorst, T.J.M., Raat, H. & Korfage, I.J. (2010). Girls' preferences for HPV vaccination: A discrete choice experiment. Vaccine, 28(41), 6692-6697. Bekker- Grob, E.W. de, Hol, L., Donkers, B., Dam, L. van, Habbema, J.D.F., Leerdam, M.E. van, Kuipers, E.J., Essink-Bot, M.L. & Steyerberg, E.W. (2010). Labeled versus Unlabeled Discrete Choice Experiments in Health Economics: An Application to Colorectal Cancer Screening. Value in Health, 13(2), 315-323. Bergh, K.A.M. van den, Essink-Bot, M.L., Klaveren, R.J. van & Koning, H.J. de (2010). Informed decision making does not affect health-related quality of life in lung cancer screening (NELSON trial). European Journal of Cancer, 46(18), 3300-3306. Bergh, K.A.M. van den, Essink-Bot, M.L., Borsboom, G.J.J.M., Scholten, ET, Prokop, M, Koning, H.J. de & Klaveren, R.J. van (2010). Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON). British Journal of Cancer, 102(1), 27-34. Bergh, R.C.N. van den, Vugt, H.A. van, Korfage, I.J., Steyerberg, E.W., Roobol, M.J., Schroder, F.H. & Essink-Bot, M.L. (2010). Disease insight and treatment perception of men on active surveillance for early prostate cancer. Bju International, 105(3), 322-328. Bergh, R.C.N. van den, Essink-Bot, M.L., Roobol, M.J., Schroder, F.H., Bangma, C.H. & Steyerberg, E.W. (2010). Do Anxiety and Distress Increase During Active Surveillance for Low Risk Prostate Cancer? Journal of Urology, 183(5), 1786-1791. Bergh, R.C.N. van den, Steyerberg, E.W., Khatami, A, Aus, G, Pihl, CG, Wolters, T., Leeuwen, P.J. van, Roobol, M.J., Schroder, F.H. & Hugosson, J. (2010). Is Delayed Radical Prostatectomy in Men With Low-Risk Screen-Detected Prostate Cancer Associated With a Higher Risk of Unfavorable Outcomes? Cancer, 116(5), 1281-1290. Bergh, R.C.N. van den, Vasarainen, H, Poel, HG van der, Vis-Maters, JJ, Rietbergen, JB, Pickles, T, Cornel, E.B., Valdagni, R, Jaspars, JJ, Hoeven, J van der, Staerman, F, Oomens, EHGM, Rannikko, A, Roemeling, S., Steyerberg, E.W., Roobol, M.J., Schroder, F.H. & Bangma, C.H. (2010). Short-term outcomes of the prospective multicentre 'Prostate Cancer Research International: Active Surveillance' study. Bju International, 105(7), 956-962. Bergh, R.C.N. van den, Essink-Bot, M.L., Roobol-Bouts, M.J., Wolters, T., Schroder, F.H., Bangma, C.H. & Steyerberg, E.W. (2010). Angst en onrust bij mannen op actieve surveillance voor laagrisico prostaatkanker? Nederlands Tijdschrift voor Urologie, 18(1), 9-16. Blok, BMJ Flokstra-de, Dubois, AEJ, Vlieg-Boerstra, BJ, Elberink, JNGO, Raat, H., DunnGalvin, A, Hourihane, JO & Duiverman, E.J. (2010). Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy, 65(2), 238-244. Boomsma, CM, Kavelaars, A., Eijkemans, M.J.C., Fauser, B.C.J.M., Heijnen, C.J. & Macklon, N.S. (2010). Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertility & Sterility, 94(5), 1764-1768. Boros, P.W., Enright, P.L., Quanjer, P.H., Borsboom, G.J.J.M., Wesolowski, S.P. & Hyatt, R.E. (2010). Impaired lung compliance and Dl,co but no restrictive ventilatory defect in sarcoidosis. European Respiratory Journal, 36, 1315-1322. Briet, MC, Berger, THD, Ballegooijen, M. van, Boon, M.E. & Rebolj, M. (2010). Effects of Streamlining Cervical Cancer Screening the Dutch Way Consequences of Changes in the Dutch KOPAC-Based Follow-up Protocol and Consensus-Based Limitation of Equivocal Cytology. Acta Cytologica, 54(6), 1095-1100. Buiting, H.M., Karelse, MAC, Brouwers, HAA, Onwuteaka-Philipsen, B.D., Heide, A. van der & Delden, J.J.M. van (2010). Dutch experience of monitoring active ending of life for newborns. Journal of Medical Ethics, 36(4), 234-237. Buiting, H.M., Heide, A. van der & Onwuteaka-Philipsen, B.D. (2010). No increase in demand for euthanasia following implementation of the Euthanasia Act in The Netherlands; pain as a reason for euthanasia request was increasing before implementation but declined subsequently. Evidence-Based Medicine, 15, 159-160. 253

Buiting, H.M., Heide, A. van der, Onwuteaka-Philipsen, B.D., Rurup, ML, Rietjens, J.A.C., Borsboom, G.J.J.M., Maas, P.J. van der & Delden, J.J.M. van (2010). Physicians' labelling of end-of-life practices: a hypothetical case study. Journal of Medical Ethics, 36(1), 24-29. Bunge, E.M., Habbema, J.D.F. & Koning, H.J. de (2010). A randomised controlled trial on the effectiveness of bracing patients with idiopathic scoliosis: failure to include patients and lessons to be learnt. European Spine Journal, 19(5), 747-753. Bunge, E.M., Bekker- Grob, E.W. de, Biezen, F.C. van, Essink-Bot, M.L. & Koning, H.J. de (2010). Patients' Preferences for Scoliosis Brace Treatment A Discrete Choice Experiment. Spine, 35(1), 57-63. Buysse, C.M.P., Vermunt, L.C.A.C., Raat, H., Hazelzet, J.A., Hop, W.C.J., Utens, E.M.W.J. & Joosten, K.F.M. (2010). Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life. Critical Care, 14(3), 124. Capelle, L.G., Haringsma, J., Vries, A.C. de, Steyerberg, E.W., Biermann, K., Dekken, H. van & Kuipers, E.J. (2010). Narrow Band Imaging for the Detection of Gastric Intestinal Metaplasia and Dysplasia During Surveillance Endoscopy. Digestive Diseases & Sciences, 55(12), 3442-3448. Capelle, L.G., Grieken, N.C.T. van, Lingsma, H.F., Steyerberg, E.W., Klokman, W.J., Bruno, M.J., Vasen, H.F.A. & Kuipers, E.J. (2010). Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands. Gastroenterology, 138(2), 487-492. Chambaere, K, Bilsen, J, Cohen, J., Rietjens, J.A.C., Onwuteaka-Philipsen, B.D., Mortier, F & Deliens, L. (2010). Continuous Deep Sedation Until Death in Belgium: A Nationwide Survey. Archives of Internal Medicine, 170(5), 490-493. Cijs, TM, Verhoef, C., Steyerberg, E.W., Koppert, L.B., Tran, T.C.K., Wijnhoven, B.P.L., Tilanus, H.W. & Jonge, J. de (2010). Outcome of Esophagectomy for Cancer in Elderly Patients. Annals of Thoracic Surgery, 90(3), 900-907. Claassen, L, Henneman, L, Janssens, A.C.J.W., Wijdenes-Pijl, M, Qureshi, N, Walter, FM, Yoon, PW & Timmermans, D.R.M. (2010). Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence. Bmc Public Health, 10. Cnossen, M.H., Aarsen, F.K., Akker, L.J. van den, Danen, R., Appel, I.M., Steyerberg, E.W. & Catsman-Berrevoets, C.E. (2010). Paediatric arterial ischaemic stroke: functional outcome and risk factors. Developmental Medicine & Child Neurology, 52, 394-399. Cox, T, Steeg, J.W. van der, Steures, P., Hompes, P.G.A., Veen, F.M. van der, Eijkemans, M.J.C., Leeuwen, JHS van, Renckens, C, Bossuyt, P.M.M. & Mol, B.W.J. (2010). Time to pregnancy after a previous miscarriage in subfertile couples. Fertility & Sterility, 94(2), 485-488. Dam, L. van, Hol, L., Bekker- Grob, E.W. de, Steyerberg, E.W., Kuipers, E.J., Habbema, J.D.F., Essink-Bot, M.L. & Leerdam, M.E. van (2010). What determines individuals' preferences for colorectal cancer screening programmes? A discrete choice experiment. European Journal of Cancer, 46(1), 150-159. Danso-Appiah, A., Stolk, W.A., Bosompem, K.M., Otchere, J, Looman, C.W.N., Habbema, J.D.F. & Vlas, S.J. de (2010). Health Seeking Behaviour and Utilization of Health Facilities for Schistosomiasis-Related Symptoms in Ghana. PLoS Neglected Tropical Diseases, 4(11). Dishoeck, A.M. van, Lingsma, H.F. & Steyerberg, E.W. (2010). Prestatie-indicatoren: de rol van taakonzekerheid. Nederlands Tijdschrift voor Geneeskunde, 154, 1775. Disseldorp, J van, Lambalk, C.B., Kwee, J, Looman, C.W.N., Eijkemans, M.J.C., Fauser, BC & Broekmans, FJ (2010). Comparison of inter- and intra-cycle variability of anti-mullerian hormone and antral follicle counts. Human Reproduction, 25(1), 221-227. Disseldorp, J van, Eijkemans, M.J.C., Fauser, B & Broekmans, F (2010). Hypertensive pregnancy complications in poor and normal responders after in vitro fertilization. Fertility & Sterility, 93(2), 652-657. Edwards, BK, Ward, E, Kohler, B.A., Eheman, C, Zauber, A.G., Anderson, RN, Jemal, A, Schymura, MJ, Lansdorp - Vogelaar, I., Seeff, LC, Ballegooijen, M. van, Goede, S.L. & Ries, LAG (2010). Annual Report to the Nation on the Status of Cancer, 1975-2006, Featuring Colorectal Cancer Trends and Impact of Interventions (Risk Factors, Screening, and Treatment) to Reduce Future Rates. Cancer, 116(3), 544-573. Eijkemans, M.J.C., Houdenhoven, M. van, Nguyen, T., Boersma, E., Steyerberg, E.W. & Kazemier, G. (2010). Predicting the Unpredictable A New Prediction Model for Operating Room Times Using Individual Characteristics and the Surgeon's Estimate. Anesthesiology, 112(1), 41-49. Elferink, MAG, Steenbergen, LN van, Krijnen, P., Lemmens, V.E.P.P., Rutten, H.J., Marijnen, CAM, Nagtegaal, ID, Karim-Kos, H.E., Vries, E. de & Siesling, S (2010). Marked improvements in survival of patients with rectal cancer in the Netherlands following changes in therapy, 1989-2006. European Journal of Cancer, 46(8), 1421-1429. Elias-Smale, S.E., Proenca, RV, Koller, M.T., Kavousi, M., Rooij, F.J.A. van, Hunink, M.G.M., Steyerberg, E.W., Hofman, A., Oudkerk, M.. & Witteman, J.C.M. (2010). Coronary Calcium Score Improves Classification of Coronary Heart Disease Risk in the Elderly The Rotterdam Study. Journal of the American College of Cardiology, 56(17), 1407-1414. 254

Ferket, B.S., Colkesen, EB, Visser, J.J., Spronk, S., Kraaijenhagen, RA, Steyerberg, E.W. & Hunink, M.G.M. (2010). Systematic Review of Guidelines on Cardiovascular Risk Assessment Which Recommendations Should Clinicians Follow for a Cardiovascular Health Check? Archives of Internal Medicine, 170(1), 27-40. Finne, P., Fallah, M, Hakama, M., Ciatto, S., Hugosson, J., Koning, H.J. de, Moss, S., Nelen, V. & Auvinen, A. (2010). Lead-time in the European Randomised Study of Screening for Prostate Cancer. European Journal of Cancer, 46(17), 3102-3108. Fischer, E.A.J., Vlas, S.J. de, Meima, A., Habbema, J.D.F. & Richardus, J.H. (2010). Different Mechanisms for Heterogeneity in Leprosy Susceptibility Can Explain Disease Clustering within Households. PLoS One, 5(11). Fransen, M.P., Wildschut, H.I.J., Mackenbach, J.P., Steegers, E.A.P., Galjaard, R.J.H. & Essink-Bot, M.L. (2010). Ethnic and socio-economic differences in uptake of prenatal diagnostic tests for Down's syndrome. 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Passive immunisation against respiratory syncytial virus: a cost-effectiveness analysis. Archives of Disease in Childhood, 95(7), 493-498. Rigter, H.G.M., Pelc, I, Tossmann, P, Phan, O, Grichting, E, Hendriks, V & Rowe, C (2010). INCANT: a transnational randomized trial of Multidimensional Family Therapy versus treatment as usual for adolescents with cannabis use disorder. BMC Psychiatry, 10. Rijnsburger, A.J., Obdeijn, A.I.M., Kaas, R., Tilanus-Linthorst, M.M.A., Boetes, C., Loo, CE, Wasser, M.N.J.M., Bergers, E, Kok, T. de, Muller, S.H., Peterse, H., Tollenaar, R.A.E.M., Hoogerbrugge, N., Meijer, S, Bartels, C.C.M., Seynaeve, C., Hooning, M.J., Kriege, M., Schmitz, P.I.M., Oosterwijk, J.C., Koning, H.J. de, Rutgers, EJT & Klijn, J.G.M. (2010). BRCA1-Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study. Journal of Clinical Oncology, 28(36), 5265-5273. Risselada, R., Lingsma, H.F., Molyneux, AJ, Kerr, RSC, Yarnold, J, Sneade, M, Steyerberg, E.W. & Sturkenboom, M.C.J.M. (2010). Prediction of two month modified Rankin Scale with an ordinal prediction model in patients with aneurysmal subarachnoid haemorrhage. BMC Medical Research Methodology, 10. Risselada, R., Lingsma, H.F., Bauer-Mehren, A, Friedrich, CM, Molyneux, AJ, Kerr, RSC, Yarnold, J, Sneade, M, Steyerberg, E.W. & Sturkenboom, M.C.J.M. (2010). Prediction of 60 day case-fatality after aneurysmal subarachnoid haemorrhage: results from the International Subarachnoid Aneurysm Trial (ISAT). European Journal of Epidemiology, 25(4), 261-266. Roobol, M.J., Steyerberg, E.W., Kranse, R., Wolters, T., Bergh, R.C.N. van den, Bangma, C.H. & Schroder, F.H. (2010). A Risk- Based Strategy Improves Prostate-Specific Antigen-Driven Detection of Prostate Cancer. European Urology, 57(1), 79-85. Roozenbeek, B., Lingsma, H.F., Steyerberg, E.W. & Maas, A.I.R. (2010). 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EMC NIHES-02-65-02 - Determinants and primary prevention Programme in brief design The research programme Determinants of Population Health and primary prevention aims to contribute to a better understanding of the specific role of social and physical determinants in population health and to develop effective primary preventive interventions that will enhance population health. The research on determinants of population health addresses the specific contribution of a wide array of factors to population health, often by applying novel quantitative methods that are able to capture the complex interrelationships among individual characteristics and behaviours and the living and working environment. This knowledge is subsequently used to develop and evaluate the effectiveness of primary preventive interventions and associated costs and benefits. These interventions are conducted in a variety of environments, such as schools, workplaces, and neighbourhoods. The research programme combines 5 research groups: determinants of health-related behaviours, social determinants of population health, occupational health, cancer surveillance, and youth health care (Prof..dr. A. Burdorf, Prof.dr. JW Coebergh, Dr. F.van Lenthe, Dr. H. Raat, Prof.dr. J. Mackenbach) and links with the research group on infectious diseases (Prof.dr. J.H. Richardus). Important contributions to public health addressed in this research programme include: - healthy growth and development of youth - healthy ageing - reducing health inequalities - work and health - combatting the obesity epidemic - improved cancer surveillance - tailored lifestyle interventions - improving health in cities - international health. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 0 0,99 1,14 0,98 3,11 public health 4,47 11,16 4,6 5,22 25,45 Total 4,47 12,15 5,74 6,2 28,56 6 2 0 8 128 13 15 164 Thesis Amiri, M. (2010, oktober 27). Trends in mortality from ischemic heart disease stroke and stomach cancer. EUR (169 pag.). Prom./coprom.: Prof. Dr. G.J. Bonsel & Dr. A.E. Kunst. Berg, T.I.J. van den (2010, oktober 29). The role of work ability and health on sustaining employability. EUR (181 pag.). Prom./coprom.: Prof. Dr. Ir. A. Burdorf. Dreier, R.P. (2010, april 01). Der Totentanz - ein Motiv der kirchlichen Kunst als Projektionsfläche für profane Botschaften (1425-1650). EUR. Prom./coprom.: Prof. Dr. J.P. Mackenbach & JA van Herwaarden. Jansen, P.M. (2010, april 01). Self-report in Youth Health Monitoring: evidence from the Rotterdam Youth Monitor. EUR (159 pag.). Prom./coprom.: Prof.Dr. M.C.H. Donker, Prof. Dr. F.C. Verhulst & EJ de Wilde. Schaap, M.M. (2010, mei 26). Socioeconomic inequalities in smoking in Europe. EUR. Prom./coprom.: Prof. Dr. J.P. Mackenbach & Dr. A.E. Kunst. Schans, SAM van de (2010, oktober 28). Progress against Non-Hodgkin Lymphoma in the Netherlands. EUR (223 pag.). Prom./coprom.: Prof. Dr. J.W.W. Coebergh, M.L.G. Janssen - Heynen & D.J. van Spronsen. Schuring, M. (2010, oktober 14). The role of health and health promotion in labour force participation. EUR (153 pag.). Prom./coprom.: Prof. Dr. J.P. Mackenbach & Prof. Dr. Ir. A. Burdorf. Steenbergen, LN van (2010, mei 27). Variation in occurrence, management, and outcome of colorectal cancer in the Netherlands, on the eve of mass screening. EUR. Prom./coprom.: Prof. Dr. J.W.W. Coebergh, Drs. V.E.P.P. Lemmens & H.J.T. Rutten. Artikel/Letter to the editor Aa, MA van der, Helmerhorst, T.J.M., Siesling, S, Riemersma, S & Coebergh, J.W. (2010). Vaginal and (Uncommon) Cervical Cancers in the Netherlands, 1989-2003. International Journal of Gynecological Cancer, 20(4), 638-645. Aarts, MJ, Mols, F, Thong, MSY, Louwman, MW, Coebergh, J.W.W. & Poll-Franse, L.V. van de (2010). Long-term Prostate Cancer Survivors With Low Socioeconomic Status Reported Worse Mental Health-related Quality of Life in a Population-based Study. Urology, 76(5), 1224-1230. Aarts, MJ, Aa, MA van der, Coebergh, J.W.W. & Louwman, W.J. (2010). Reduction of socioeconomic inequality in cancer incidence in the South of the Netherlands during 1996-2008. European Journal of Cancer, 46(14), 2633-2646. Aarts, MJ, Lemmens, V.E.P.P., Louwman, W.J., Kunst, A.E. & Coebergh, J.W.W. (2010). Socioeconomic status and changing inequalities in colorectal cancer? A review of the associations with risk, treatment and outcome. European Journal of Cancer, 46(15), 2681-2695. 263

Andersson, K, Bray, F, Arbyn, M., Storm, H., Zanetti, R, Hallmans, G, Coebergh, J.W.W. & Dillner, J. (2010). The interface of population-based cancer registries and biobanks in etiological and clinical research - current and future perspectives. Acta Oncologica, 49(8), 1227-1234. Arnold, M., Razum, O & Coebergh, J.W.W. (2010). Cancer risk diversity in non-western migrants to Europe: An overview of the literature. European Journal of Cancer, 46(14), 2647-2659. Baars, J.E., Boon, BJF, Garretsen, H.F.L. & Mheen, D. van de (2010). The reach of a free hepatitis B vaccination programme: Results of a Dutch study among drug users. International Journal of Drug Policy, 21(3), 247-250. Bakker, R., Pluimgraaff, L.E., Steegers, E.A.P., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Associations of light and moderate maternal alcohol consumption with fetal growth characteristics in different periods of pregnancy: The Generation R Study. International Journal of Epidemiology, 39(3), 777-789. Bakker, R., Steegers, E.A.P., Obradov, A, Raat, H., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study. American Journal of Clinical Nutrition, 91(6), 1691-1698. Bakker, R., Steegers, E.A.P., Mackenbach, J.P., Hofman, A. & Jaddoe, V.W.V.K. (2010). Maternal smoking and blood pressure in different trimesters of pregnancy: The Generation R Study. Journal of Hypertension, 28(11), 2210-2218. Beelen, M.E.J. van, Beirens, T.M.J., Struijk, M.K., Hertog, P. den, Oenema, A., Beeck, E.F. van & Raat, H. (2010). 'BeSAFE', effect-evaluation of internet-based, tailored safety information combined with personal counselling on parents' child safety behaviours: study design of a randomized controlled trial. Bmc Public Health, 10. Beirens, T.M.J., Beeck, E.F. van, Brug, J., Hertog, P. den & Raat, H. (2010). Why do parents with toddlers store poisonous products safely. International Journal of Pediatrics, 702827. Berg, T.I.J. van den, Elders, L.A.M. & Burdorf, A. (2010). Influence of Health and Work on Early Retirement. Journal of Occupational and Environmental Medicine, 52(6), 576-583. Berg, T.I.J. van den, Schuring, M., Avendano Pabon, M., Mackenbach, J.P. & Burdorf, A. (2010). The impact of ill health on exit from paid employment in Europe among older workers. Occupational and Environmental Medicine, 67(12), 845-852. Blok, BMJ Flokstra-de, Dubois, AEJ, Vlieg-Boerstra, BJ, Elberink, JNGO, Raat, H., DunnGalvin, A, Hourihane, JO & Duiverman, E.J. (2010). Health-related quality of life of food allergic patients: comparison with the general population and other diseases. Allergy, 65(2), 238-244. Blokker, BM, Janssen, JHA & Beeck, E.F. van (2010). Referral patterns of patients presenting with chest pain at two rural emergency departments in Western Australia. Rural and remote health, 10(3). Blom, E.A., Jansen, P.W., Verhulst, F.C., Hofman, A., Raat, H., Jaddoe, V.W.V.K., Coolman, M., Steegers, E.A.P. & Tiemeier, H.W. (2010). Perinatal complications increase the risk of postpartum depression. The Generation R Study. Bjog-An International Journal of Obstetrics and Gynaecology, 117(11), 1390-1398. Brouwer, W., Oenema, A., Raat, H., Crutzen, R, Nooijer, J. de, Vries, N.K de & Brug, J. (2010). Characteristics of visitors and revisitors to an Internet-delivered computer-tailored lifestyle intervention implemented for use by the general public. Health Education Research, 25(4), 585-595. Brug, J., Lien, N, Klepp, KI & Lenthe, F.J. van (2010). Exploring overweight, obesity and their behavioural correlates among children and adolescents: results from the Health-promotion through Obesity Prevention across Europe project. Public Health Nutrition, 13(10A), 1676-1679. Bults, M., Beaujean, D.J., Zwart, O. de, Kok, G., Empelen, P. van, Steenbergen, J.E. van, Richardus, J.H. & Voeten, H.A.C.M. (2010). Mexicaanse griep: risicoperceptie bij de bevolking, eigen maatregelen en vertrouwen in overheidsinformatie. Nederlands Tijdschrift voor Geneeskunde, 154, 1686. Burdorf, A. (2010). Is early retirement good for your health? British Medical Journal, 341. Burdorf, A. & Elders, L.A.M. (2010). Occupational medicine in The Netherlands. Occupational Medicine-Oxford, 60(4), 314. Burdorf, A. (2010). Research in occupational medicine in the Netherlands: responsiveness to societal needs. Occupational Medicine-Oxford, 60(4), 242-244. Burdorf, A. (2010). The role of assessment of biomechanical exposure at the workplace in the prevention of musculoskeletal disorders. Scandinavian Journal of Work Environment & Health, 36(1), 1-2. Burdorf, A. (2010). De overheid bevordert sociaal-economische gezondheidsverschillen door haar AOW-beleid. TSG, 88(1), 1-2. Cattaneo, A, Monasta, L, Stamatakis, E, Lioret, S, Castetbon, K, Frenken, F, Manios, Y, Moschonis, G, Savva, S, Zaborskis, A, Rito, AI, Nanu, M, Vignerova, J, Caroli, M, Ludvigsson, J, Koch, FS, Serra-Majem, L, Szponar, L, Lenthe, F.J. van & Brug, J. (2010). Overweight and obesity in infants and pre-school children in the European Union: a review of existing data. Obesity Reviews, 11(5), 389-398. Cauwenberghe, E Van, Maes, L, Spittaels, H, Lenthe, F.J. van, Brug, J., Oppert, JM & Bourdeaudhuij, I De (2010). Effectiveness of school-based interventions in Europe to promote healthy nutrition in children and adolescents: systematic review of published and 'grey' literature. British Journal of Nutrition, 103(6), 781-797. 264

Coebergh, J.W.W., Martin-Moreno, JM, Soerjomataram, I. & Renehan, AG (2010). The long road towards cancer prevention: 4 steps backward and 8 forward. European Journal of Cancer, 46(14), 2660-2662. Coolman, M., Groot, C.J.M. de, Jaddoe, V.W.V.K., Hofman, A., Raat, H. & Steegers, E.A.P. (2010). Medical record validation of maternally reported history of preeclampsia. Journal of Clinical Epidemiology, 63(8), 932-937. Cremers, RGHM, Karim-Kos, H.E., Houterman, S, Verhoeven, RHA, Schroder, F.H., Kwast, T.H. van der, Kil, P.J.M., Coebergh, J.W.W. & Kiemeney, L.A.L.M. (2010). Prostate cancer: Trends in incidence, survival and mortality in the Netherlands, 1989-2006. European Journal of Cancer, 46(11), 2077-2087. Dalmau-Bueno, A, Garcia-Altes, A, Mari-Dell'Olmo, M, Perez, K, Espelt, A, Kunst, A.E. & Borrell, C. (2010). Trends in socioeconomic inequalities in cirrhosis mortality in an urban area of Southern Europe: a multilevel approach. Journal of Epidemiology & Community Health, 64(8), 720-727. Dalmau-Bueno, A, Garcia-Altes, A, Mari-Dell'Olmo, M, Perez, K, Kunst, A.E. & Borrell, C. (2010). Trends in socioeconomic inequalities in mortality over a twenty-two-year period in the city of Barcelona (Spain). Gaceta Sanitaria, 24(1), 20-27. Dassen, AE, Lemmens, V.E.P.P., Poll-Franse, L.V. van de, Creemers, G, Brenninkmeijer, SJ, Lips, DJ, Wurff, AAMV, Bosscha, K. & Coebergh, J.W.W. (2010). Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands. European Journal of Cancer, 46(6), 1101-1110. Driece, H.A.L., Siesling, S, Swuste, P.H.J.J. & Burdorf, A. (2010). Assessment of cancer risks due to environmental exposure to asbestos. Journal of Exposure Science and Environmental Epidemiology, 20(5), 478-485. Duijn, M. van, Eijkemans, M.J.C., Koes, B.W., Koopmanschap, M.A., Burton, KA & Burdorf, A. (2010). The effects of timing on the cost-effectiveness of interventions for workers on sick leave due to low back pain. Occupational and Environmental Medicine, 67(11), 744-750. Eikemo, T.A., Huisman, M., Perlman, F & Ringdal, K (2010). Educational health inequalities in former Yugoslavia: evidence from the South-East European Social Survey Project. European Journal of Public Health, 20(6), 640-646. Erasmus, V., Beeck, E.F. van & Vos, M. (2010). Hand Hygiene Product Volume Measurement: An Integral Part of a Multiple- Method Program Reply. Infection Control & Hospital Epidemiology, 31(9), 981-981. Erasmus, V., Kuperus, M.N., Richardus, J.H., Vos, M.C., Oenema, A. & Beeck, E.F. van (2010). Improving hand hygiene behaviour of nurses using action planning: a pilot study in the intensive care unit and surgical ward. Journal of Hospital Infection, 76(2), 161-164. Erasmus, V., Daha, TJ, Brug, J., Richardus, J.H., Behrendt, M.D. & Vos, M. (2010). Systematic Review of Studies on Compliance with Hand Hygiene Guidelines in Hospital Care. Infection Control & Hospital Epidemiology, 31(3), 283-294. Erasmus, V., Eijsden, A.M. van, Daha, Th.J., Richardus, J.H., Empelen, P. van, Oenema, A., Brug, J., Vos, M.C.P.J. de & Beeck, E.F. van (2010). Handhygiëne in Nederlandse ziekenhuizen: een kwestie van gewoonte? Nederlands Tijdschrift voor Hygiëne en Infectiepreventie, 28(3), 51. Erdogan-Ciftci, E, Doorslaer, E.K.A. van, Bago d'uva, T.M. & Lenthe, F.J. van (2010). Do self-perceived health changes predict longevity? Social Science & Medicine, 71(11), 1981-1988. Espelt, A, Borrell, C., Rodriguez-Sanz, M, Muntaner, C., Pasarin, MI, Benach, J., Schaap, M.M., Kunst, A.E. & Navarro, V (2010). Answer to the commentary: Politics and public healthsome conceptual considerations concerning welfare state characteristics and public health outcomes. International Journal of Epidemiology, 39(2), 630-632. Ezendam, N.P.M., Evans, AE, Stigler, MH, Brug, J. & Oenema, A. (2010). Cognitive and home environmental predictors of change in sugar-sweetened beverage consumption among adolescents. British Journal of Nutrition, 103(5), 768-774. Flohil, S.C., Vries, E. de, Meurs, J.B.J. van, Fang, Y., Stricker, B.H.C., Uitterlinden, A.G. & Nijsten, T.E.C. (2010). Vitamin D- binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas. Experimental Dermatology, 19(12), 1103-1105. Geelhoed, M.J.J., Steegers, E.A.P., Koper, J.W., Rossum, E.F.C. van, Moll, H.A., Raat, H., Tiemeier, H.W., Hofman, A. & Jaddoe, V.W.V.K. (2010). Glucocoricoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. BMC Medical Genetics, 11(39). Genugten, L. van, Empelen, P. van, Flink, I & Oenema, A. (2010). Systematic development of a self-regulation weightmanagement intervention for overweight adults. Bmc Public Health, 10. Giskes, K., Avendano Pabon, M., Brug, J. & Kunst, A.E. (2010). A systematic review of studies on socioeconomic inequalities in dietary intakes associated with weight gain and overweight/obesity conducted among European adults. Obesity Reviews, 11(6), 413-429. Glymour, MM, Maselko, J, Gilman, SE, Patton, KK & Avendano Pabon, M. (2010). Depressive symptoms predict incident stroke independently of memory impairments. Neurology, 75(23), 2063-2070. Groen, E. de & Raat, H. (2010). Asthma Research and Randomized Controlled Trials: A Remarkable Phenomenon. Journal of Asthma, 47(9), 1063-1064. 265

Haas, E.R.M. de, Nijsten, T.E.C. & Vries, E. de (2010). Population Education in Preventing Skin Cancer: From Childhood to Adulthood. Journal of Drugs in Dermatology, 9(2), 112-116. Hartholt, K.A., Velde, N. van der, Looman, C.W.N., Panneman, MJM, Beeck, E.F. van, Patka, P. & Cammen, T.J.M. van der (2010). Adverse Drug Reactions Related Hospital Admissions in Persons Aged 60 Years and over, The Netherlands, 1981-2007: Less Rapid Increase, Different Drugs. PLoS One, 5(11). Hartholt, K.A., Velde, N. van der, Looman, C.W.N., Lieshout, E.M.M. van, Panneman, MJM, Beeck, E.F. van, Patka, P. & Cammen, T.J.M. van der (2010). Trends in Fall-Related Hospital Admissions in Older Persons in the Netherlands. Archives of Internal Medicine, 170(10), 905-911. Havelaar, A.H., Rosse, F van, Bucura, C, Toetenel, MA, Haagsma, J.A., Kurowicka, D, Heesterbeek, JAP, Speybroeck, N., Langelaar, MFM, Giessen, J.W.B. van der, Cooke, RM & Braks, MAH (2010). Prioritizing Emerging Zoonoses in The Netherlands. PLoS One, 5(11). Heederik, D. & Burdorf, A. (2010). Asbest, nieuwe evaluatie legt nadruk op kwaliteit karakterisering expositie. Tijdschrift voor Toegepaste Arbowetenschap, 23(2), 42-43. Herk-Sukel, M.P.P., Poll-Franse, L.V. van de, Voogd, A.C., Nieuwenhuijzen, G.A.P., Coebergh, J.W.W. & Herings, R.M.C. (2010). Half of breast cancer patients discontinue tamoxifen and any endocrine treatment before the end of the recommended treatment period of 5 years: a population-based analysis. Breast Cancer Research and Treatment, 122(3), 843-851. Herk-Sukel, M.P.P., Poll-Franse, L.V. van de, Lemmens, V.E.P.P., Vreugdenhil, G., Pruijt, J.F.M., Coebergh, J.W.W. & Herings, R.M.C. (2010). New opportunities for drug outcomes research in cancer patients: The linkage of the Eindhoven Cancer Registry and the PHARMO Record Linkage System. European Journal of Cancer, 46(2), 395-404. Hilsen, M, Eikemo, T.A. & Bere, E (2010). Healthy and unhealthy eating at lower secondary school in Norway. Scandinavian Journal of Public Health, 38, 7-12. Hoedjes, M., Berks, D., Vogel, I., Franx, A., Visser, W., Duvekot, J.J., Habbema, J.D.F., Steegers, E.A.P. & Raat, H. (2010). Effect of Postpartum Lifestyle Interventions on Weight Loss, Smoking Cessation, and Prevention of Smoking Relapse: A Systematic Review. Obstetrical and Gynecological Survey, 65(10), 631-652. Holterhues, C., Vries, E. de, Louwman, MW, Koljenovic, S. & Nijsten, T.E.C. (2010). Incidence and Trends of Cutaneous Malignancies in the Netherlands, 1989-2005. Journal of Investigative Dermatology, 130(7), 1807-1812. Horst, K.A. van der, Oenema, A., Velde, S.J. te & Brug, J. (2010). Do individual cognitions mediate the association of sociocultural and physical environmental factors with adolescent sports participation? Public Health Nutrition, 13(10A), 1746-1754. Houweling, A.J. & Kunst, A.E. (2010). Socio-economic inequalities in childhood mortality in low- and middle-income countries: a review of the international evidence. British Medical Bulletin, 93(1), 7-26. Huijgens, P.C., Posthuma, E.F.M., Coebergh, J.W.W., Poll-Franse, L.V. van de, Uyl - de Groot, C.A. & Sonneveld, P. (2010). Een 'population based registry' voor hemato-oncologie. Nederlands Tijdschrift voor Hematologie, 7(8), 321-324. Huijts, T, Eikemo, T.A. & Skalicka, V (2010). Income-related health inequalities in the Nordic countries: Examining the role of education, occupational class, and age. Social Science & Medicine, 71(11), 1964-1972. Hume, C, Horst, K.A. van der, Brug, J., Salmon, J & Oenema, A. (2010). Understanding the correlates of adolescents' TV viewing: A social ecological approach. International Journal of Pediatric Obesity, 5(2), 161-168. Jaddoe, V.W.V.K., Duijn, C.M. van, Heijden, A.J. van der, Mackenbach, J.P., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2010). The Generation R Study: design and cohort update 2010. European Journal of Epidemiology, 25(11), 823-841. Jagger, C., Gillies, C, Cambois, E, Oyen, H van, Nusselder, W.J. & Robine, JM (2010). The Global Activity Limitation Index measured function and disability similarly across European countries. Journal of Clinical Epidemiology, 63(8), 892-899. Jansen, P.W., Tiemeier, H.W., Verhulst, F.C., Burdorf, A., Jaddoe, V.W.V.K., Hofman, A., Moll, H.A., Verburg, B.O., Steegers, E.A.P., Mackenbach, J.P. & Raat, H. (2010). Employment status and the risk of pregnancy complications: the Generation R Study. Occupational and Environmental Medicine, 67, 387-394. Jansen, P.W., Raat, H., Mackenbach, J.P., Jaddoe, V.W.V.K., Hofman, A., Oort, F.V.A. van, Verhulst, F.C. & Tiemeier, H.W. (2010). National Origin and Behavioural Problems of Toddlers: The Role of Family Risk Factors and Maternal Immigration Characteristics. Journal of Abnormal Child Psychology, 38(8), 1151-1164. Jansen, W., Mackenbach, J.P., Zwanenburg, E Joosten-van & Brug, J. (2010). Weight status, energy-balance behaviours and intentions in 9-12-year-old inner-city children. Journal of Human Nutrition and Dietetics, 23(1), 85-96. Janssen - Heynen, M.L.G., Szerencsi, K, Schans, SAM van de, Maas, H.A.A.M., Widdershoven, JW & Coebergh, J.W.W. (2010). Cancer patients with cardiovascular disease have survival rates comparable to cancer patients within the age-cohort of 10 years older without cardiovascular morbidity. Critical Reviews in Oncology/Hematology, 76(3), 196-207. Janssen - Heynen, M.L.G., Gondos, A, Bray, F, Hakulinen, T., Brewster, DH, Brenner, H & Coebergh, J.W.W. (2010). Clinical Relevance of Conditional Survival of Cancer Patients in Europe: Age-Specific Analyses of 13 Cancers. Journal of Clinical Oncology, 28(15), 2520-2528. 266

Jong, J.C. de, Escher, J.C., Arends, L.R., Jaddoe, V.W.V.K., Hofman, A., Raat, H. & Moll, H.A. (2010). Infant nutritional factors and functional constipation in childhood: The Generation R Study. American Journal of Gastroenterology, 105, 940-945. Joosse, A., Vries, E. de, Eijck, C.H.J. van, Eggermont, A.M.M., Nijsten, T.E.C. & Coebergh, J.W.W. (2010). Reactive oxygen species and melanoma: an explanation for gender differences in survival? Pigment Cell & Melanoma Research, 23(3), 352-364. Kamphuis, C.B.M., Mackenbach, J.P., Giskes, K., Huisman, M., Brug, J. & Lenthe, F.J. van (2010). Why do poor people perceive poor neighbourhoods? The role of objective neighbourhood features and psychosocial factors. Health & Place, 16(4), 744-754. Kiiski, V, Vries, E. de, Flohil, S.C., Bijl, M.J., Hofman, A., Stricker, B.H.C. & Nijsten, T.E.C. (2010). Risk Factors for Single and Multiple Basal Cell Carcinomas. Archives of Dermatology, 146(8), 848-855. Klijs, B., Mackenbach, J.P. & Kunst, A.E. (2010). Disability occurrence and proximity to death. Disability & Rehabilitation, 32(21), 1733-1741. Koomen, ER, Vries, E. de, Kempen, LC van, Akkooi, A.C.J. van, Guchelaar, HJ, Louwman, W.J., Nijsten, T.E.C. & Coebergh, J.W.W. (2010). Epidemiology of Extracutaneous Melanoma in the Netherlands. Cancer Epidemiology Biomarkers & Prevention, 19(6), 1453-1459. Kreuger, F.A.F., Voorham, A.J.J., Veen, A van der & Richardus, J.H. (2010). Kortdurende onderzoeksprojecten `Klein maar Fijn : het verbinden van praktijk, beleid en onderzoek. TSG, 88(4), 161-165. Lemmens, V.E.P.P., Steenbergen, L van, Janssen - Heynen, M.L.G., Martijn, H., Rutten, H. & Coebergh, J.W. (2010). Trends in colorectal cancer in the south of the Netherlands 1975-2007: Rectal cancer survival levels with colon cancer survival. Acta Oncologica, 49(6), 784-796. Lenthe, F.J. van, Kamphuis, C.B.M., Giskes, K., Huisman, M., Brug, J. & Mackenbach, J.P. (2010). Sociaal-economische verschillen in recreatief bewegen - De rol van fysieke en sociale leefomgeving. TSG, 88(1), 32-40. Lhachimi, S.K., Nusselder, W.J., Boshuizen, H.C. & Mackenbach, J.P. (2010). Standard Tool for Quantification in Health Impact Assessment A Review. American Journal of Preventive Medicine, 38(1), 78-84. Louwman, W.J., Aarts, MJ, Houterman, S., Lenthe, F.J. van, Coebergh, J.W.W. & Janssen - Heynen, M.L.G. (2010). A 50% higher prevalence of life-shortening chronic conditions among cancer patients with low socioeconomic status. British Journal of Cancer, 103(11), 1742-1748. Mackenbach, J.P. (2010). Has the English strategy to reduce health inequalities failed? Social Science & Medicine, 71(7), 1249-1253. Mackenbach, J.P. (2010). New trends in health inequalities research: now it's personal. Lancet (UK), 376(9744), 854-855. Mackenbach, J.P. (2010). Te weinig preventie in verkiezingsprogramma s. Nederlands Tijdschrift voor Geneeskunde, 154, 573. Meerding, W.J., Polinder, S., Lyons, RA, Petridou, ET, Toet, H., Beeck, E.F. van & Mulder, S. (2010). How adequate are emergency department home and leisure injury surveillance systems for cross-country comparisons in Europe? International Journal of injury control and safety promotion, 17(1), 13-22. Menvielle, G.F.M., Boshuizen, H, Kunst, A.E., Vineis, P, Dalton, SO, Bergmann, MM, Hermann, S, Veglia, F, Ferrari, P, Overvad, K, Raaschou-Nielsen, O, Tjonneland, A, Kaaks, R, Linseisen, J, Palli, D, Krogh, V, Tumino, R, Rodriguez, L, Agudo, A, Sanchez, MJ, Arozena, JMA, Cirera, L, Ardanaz, E, Bingham, S, Khaw, KT, Boffetta, P., Duell, E, Slimani, N, Gallo, V, Riboli, E & Bueno-de-Mesquita, HB (2010). Occupational exposures contribute to educational inequalities in lung cancer incidence among men: evidence from the EPIC prospective cohort study. International Journal of Cancer, 126(8), 1928-1935. 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Nusselder, W.J., Looman, C.W.N., Oyen, H van, Robine, JM & Jagger, C. (2010). Gender differences in health of EU10 and EU15 populations: the double burden of EU10 men. European Journal of Ageing, 7(4), 219-227. Oostenbrink, R., Jongman, H., Landgraf, J.M., Raat, H. & Moll, H.A. (2010). Functional abdominal complaints in pre-school children: parental reports of health-related quality of life. Quality of Life Research, 19, 363-369. Oyen, H van, Cox, B., Jagger, C., Cambois, E, Nusselder, W.J., Gilles, C & Robine, JM (2010). Gender gaps in life expectancy and expected years with activity limitations at age 50 in the European Union: associations with macro-level structural indicators. European Journal of Ageing, 7(4), 229-237. Patiwael, J.A., Jong, N.W. de, Burdorf, A., Groot, H. de & Gerth van Wijk, R. (2010). Occupational allergy to bell pepper pollen in greenhouses in the Netherlands, an 8-year follow-up study. Allergy, 65(11), 1423-1429. 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Veling, W., Susser, E., Os, J. van, Mackenbach, J.P., Selten, J.P. & Hoek, H.W. (2010). Incidentie van psychotische stoornissen bij immigranten hangt samen met etnische dichtheid van wijken. Nederlands Tijdschrift voor Geneeskunde, 154(15), 1767. Verhoeven, RHA, Louwman, W.J., Koldewijn, E.L., Demeyere, TBJ & Coebergh, J.W.W. (2010). Scrotal cancer: incidence, survival and second primary tumours in the Netherlands since 1989. British Journal of Cancer, 103(9), 1462-1466. Visser, A.M., Jaddoe, V.W.V.K., Hofman, A., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Raat, H., Breteler, M.M.B. & Arts, W.F.M. (2010). Fetal Growth Retardation and Risk of Febrile Seizures. Pediatrics, 126(4), E919-E925. Vogel, I., Brug, J., Ploeg, C.P.B. van der & Raat, H. (2010). Discotheques and the risk of hearing loss among youth: risky listening behavior and its psychosocial correlates. Health Education Research, 25(5), 737-747. Vogel, I., Verschuure, J., Ploeg, C.P.B. van der, Brug, J. & Raat, H. (2010). Estimating Adolescent Risk for Hearing Loss Based on Data From a Large School-Based Survey. American Journal of Public Health, 100(6), 1095-1100. Vogel, I., Brug, J., Ploeg, C.P.B. van der & Raat, H. (2010). Young People: Taking Few Precautions Against Hearing Loss in Discotheques. Journal of Adolescent Health, 46(5), 499-502. Voogd, A.C. & Coebergh, J.W.W. (2010). Explaining variations in survival in breast cancer in the Eastern Region of England. Annals of Oncology, 21(3), 669-U241. Voogd, A.C., Duijm, L.E.M. & Coebergh, J.W.W. (2010). Meer borstkankersterfte 2008: preventie intensiveren. Nederlands Tijdschrift voor Geneeskunde, 154(6), 1550. Vries, E. de, Joosse, A. & Coebergh, J.W.W. (2010). Extra attention for melanoma among elderly men. Nature Reviews Clinical Oncology, 7(6). Vries, E. de, Soerjomataram, I., Lemmens, V.E.P.P., Coebergh, J.W.W., Barendregt, JJ, Oenema, A., Moller, H, Brenner, H & Renehan, AG (2010). Lifestyle changes and reduction of colon cancer incidence in Europe: A scenario study of physical activity promotion and weight reduction. European Journal of Cancer, 46(14), 2605-2616. Vries, E. de, Karim-Kos, H.E., Janssen - Heynen, M.L.G., Soerjomataram, I., Kiemeney, LA & Coebergh, J.W.W. (2010). OPINION Explanations for worsening cancer survival. Nature Reviews Clinical Oncology, 7(1), 60-63. Part of book - abstract Burdorf, A. (2010). Langer gezond werken: uitdagingen en noodzakelijke maatregelen. In De grote uittocht: negen essays over de arbeidsmarkt van de onderwijs- en overheidssectoren (pp. 165-195). Den haag: Verbond Sectorwerkgevers Overheid,Samenwerkende Centrales Overheidspersoneel,Ministerie van Binnenlandse Zaken en Koninkrijksrelaties. Kunst, A.E. & Roskam, A.J.R. (2010). Using the ESEC to describe socioeconomic inequalities in health in Europe. In EH David Rose (Ed.), Social Class in Europe: an introduction to the European Socio-economic classification (pp. 216-234). London/New York: Routledge. Voogd, A.C., Louwman, W.J. & Coebergh, J.W.W. (2010). Clinical epidemiology and the Impact of Co-Morbidity on Survival. In MW Reed & RA Audisio (Eds.), Management of breast cancer in older women (pp. 37-50). London: Springer Verlag. Boekredactie Mackenbach, J.P. (Ed.). (2010). Trends in volksgezondheid en gezondheidszorg. Amsterdam: Elsevier gezondheidszorg. Rapport Bonsel, G.J., Birnie, E., Denktas, S., Poeran, J & Steegers, E.A.P. (2010). Lijnen in perinatale sterfte. Rotterdam: EraasmusMC. Eysink, PED, Hamberg-van Reenen, HH, Gool, CH van, Hoeymans, N. & Burdorf, A. (2010). Meten van verloren arbeidsjaren door ziekte: Disease-Adjusted Working Years (DAWY): verkenning van een nieuwe maat. Bilthoven: RIVM. Inaugurale rede Burdorf, A. (2010). Werken aan volksgezondheid: van woorden naar daden (2010, september 24). Rotterdam: Erasmus MC. Voordracht - Lezing Maas, P.J. van der (2010, januari 29). Volksgezondheid: maakbaar en breekbaar. Rotterdam, Afscheidscollege Hoogleraar met de leeropdracht maatschappelijke Gezondheidszorg. 270

EMC NIHES-02-67-01 - Clinical research in general practice. Programme in brief design The aim of research activities of the Department of General Practice is to do research of academic quality, based on and derived from issues in general practice, aimed at the enhancement of the quality of general practice and supporting the academic workplace of general practice.the research encompasses the scientific basis and quality improvement of general practice. The most important components are studies of occurrence and course of disease and clinical research into the effects of preventive, diagnostic, and therapeutic strategies in general practice by clinical epidemiologic studies and randomised trials. The results of these studies are used in decision analysis and guideline development. Within this research programme patient-centered studies in the field of musculoskeletal disorders and diseases in childhood dominate. In view of the comprehensive approach of general practice other fields are occasionally addressed as well.main research themes of the chair of Intellectual Disability Medicine (Prof Evenhuis) are 'Cerebral visual impairment', 'Comorbidity in children with severe generalized cerebral palsy' and, since 2008, `Healthy Ageing and intellectual disabilities. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot family practice 10,07 4,31 0,38 2,28 17,04 Total 10,07 4,31 0,38 2,28 17,04 5 0 0 5 69 6 26 106 Thesis Rieken, R. (2010, december 08). Assessing body composition and energy expenditure in children with severe neurological impairment and intellectual disability. EUR (154 pag.). Prom./coprom.: Prof.Dr. D. Tibboel, Prof.Dr. H.M. Evenhuis & Dr. C. Penning. Rijn, R.M. van (2010, december 01). Acute ankle sprains in primary care. EUR (161 pag.). Prom./coprom.: Prof. Dr. B.W. Koes & Prof. Dr. S.M.A. Bierma-Zeinstra. Schouten, B.W.V. (2010, september 08). Focusing on erectile function beyond midlife. Results of the longitudinal part of The Krimpen Study. EUR (163 pag.). Prom./coprom.: Prof. Dr. P.J.E. Bindels, Prof.Dr. J.L.H.R. Bosch & Dr. A.M. Bohnen. Tas, U. (2010, maart 10). Determinants of disability in the elderly. EUR (144 pag.). Prom./coprom.: Prof. Dr. B.W. Koes & A.P. Verhagen. Vonk, F. (2010, juni 02). Physiotherapy for chronic neck pain. Evaluation of a biopsychosocial approach. EUR (165 pag.). Prom./coprom.: Prof. Dr. B.W. Koes & A.P. Verhagen. Artikel/Letter to the editor Arts, M.P., Brand, R., Koes, B.W. & Peul, W.C. (2010). Effect modifiers of outcome of surgery in patients with herniated disc related sciatica? A subgroup analysis of a randomised clinical trial. Journal of Neurology Neurosurgery and Psychiatry, 81(11), 1265-1274. Belo, J.N. (2010). Beschouwing; niet-traumatische knieklachten bij volwassen: prognose en beleid. Huisarts en Wetenschap, 257-262. Belo, J.N., Berg, HF, Klein Ikkink, AJ, Wildervanck-Dekker, CMI, Smorenburg, HAAI & Draijer, L.W. (2010). NHG-Standaard traumatische knieproblemen (M66); eerste herziening. Huisarts en Wetenschap, 3, 147-158. Berger, M.Y., Wit, N. de & Bindels, P.J.E. (2010). Kinderen beter af bij de huisarts. Medisch Contact, 65, 2082-2084. Beune, EJAJ, Bindels, P.J.E., Mohrs, J, Stronks, K. & Haafkens, J.A. (2010). Pilot study evaluating the effects of an intervention to enhance culturally appropriate hypertension education among healthcare providers in a primary care setting. Implementation Science, 5. Bierma-Zeinstra, S.M.A. & Runhaar, J. (2010). Bewegen en artrose. Huisarts en Wetenschap, 53, 257-262. Binsbergen, J.J. van, Langens, FNM, Dapper, ALM, Halteren, MM van, Glijsteen, R., Cleyndert, GA, Menekamp-Oei, SN & Avendonk, MJP van (2010). NHG-Standaard M95. NHG-Standaard Obesitas. Huisarts en Wetenschap, 53(11), 609-625. Boot, F.H., Pel, J.J.M., Steen, J. van der & Evenhuis, H.M. (2010). Cerebral Visual Impairment: Which perceptive visual dysfunctions can be expected in children with brain damage? A systematic review. Research in Developmental Disabilities, 31(6), 1149-1159. Bouterse, M, Hooiveld, M & Berger, M.Y. (2010). Obstipatie. Huisarts en Wetenschap, 53(9), 463. Brinks, A., Koes, B.W., Volkers, A.C.W., Verhaar, J.A.N. & Bierma-Zeinstra, S.M.A. (2010). Adverse effects of extra-articular corticosteroid injections: a systematic review. BMC Musculoskeletal Disorders, 11. Bruggink, SC, Gussekloo, J, Berger, M.Y., Zaaijer, K, Assendelft, W.J.J., Waal, MWM de, Bavinck, JNB, Koes, B.W. & Eekhof, JAH (2010). Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial. CMAJ. Canadian Medical Association Journal, 182(15), 1624-1630. 271

Calis, E.A.C., Veugelers, R., Rieken, R., Tibboel, D., Evenhuis, H.M. & Penning, C. (2010). Energy intake does not correlate with nutritional state in children with severe generalized cerebral palsy and intellectual disability. Clinical Nutrition, 29(5), 617-621. Dros, J., Maarsingh, OR, Horst, HE van der, Bindels, P.J., Riet, G. ter & Weert, H.C. (2010). Tests used to evaluate dizziness in primary care. CMAJ. Canadian Medical Association Journal, 182(13), E621-E631. Duijn, M. van, Eijkemans, M.J.C., Koes, B.W., Koopmanschap, M.A., Burton, KA & Burdorf, A. (2010). The effects of timing on the cost-effectiveness of interventions for workers on sick leave due to low back pain. Occupational and Environmental Medicine, 67(11), 744-750. Elshout, G., Hordijk, M.L. & Wouden, J.C. v.d. (2010). Delayed Therapy for Otitis Media. Pediatric Infectious Disease Journal, 29(12), 1154-1155. Ende, CM van den, Bierma-Zeinstra, S.M.A., Vlieland, TPMV, Swierstra, B.A., Voorn, Th.B. & Dekker, J. (2010). Conservative treatment of hip and knee osteoarthritis: a systematic, step-by-step treatment strategy]. Nederlands Tijdschrift voor Geneeskunde, 154, 1574. Groen, E.J., Wouden, J.C. van der & Bindels, P.J.E. (2010). Antipsychotica: let op metabole bijwerkingen. Huisarts en Wetenschap, 53(9), 504-507. Henschke, N, Kuijpers, T, Rubinstein, SM, Middelkoop, M. van, Ostelo, R, Verhagen, A.P., Koes, B.W. & Tulder, M.W. van (2010). Injection therapy and denervation procedures for chronic low-back pain: a systematic review. European Spine Journal, 19(9), 1425-1449. Hermans, H. & Evenhuis, H.M. (2010). Characteristics of instruments screening for depression in adults with intellectual disabilities: Systematic review. Research in Developmental Disabilities, 31(6), 1109-1120. Hilgenkamp, T.I.M., Wijck, R van & Evenhuis, H.M. (2010). Physical fitness in older people with ID-Concept and measuring instruments: A review. Research in Developmental Disabilities, 31(5), 1027-1038. Hordijk, J.C., Luijsterburg, P.A.J., Koes, B.W. & Verhagen, A.P. (2010). Prognostische factoren bij een lumbosacraal radiculair syndroom. Huisarts en Wetenschap, 53(9), 474-478. Huisstede, B.M., Hoogvliet, P., Randsdorp, M.S., Glerum, S., Middelkoop, M. van & Koes, B.W. (2010). Carpal Tunnel Syndrome. Part I: Effectiveness of Nonsurgical Treatments-A Systematic Review. Archives of Physical Medicine and Rehabilitation, 91(7), 981-1004. Huisstede, B.M., Randsdorp, M.S., Coert, J.H., Glerum, S., Middelkoop, M. van & Koes, B.W. (2010). Carpal Tunnel Syndrome. Part II: Effectiveness of Surgical Treatments-A Systematic Review. Archives of Physical Medicine and Rehabilitation, 91(7), 1005-1024. Huisstede, B.M., Middelkoop, M. van, Randsdorp, M.S., Glerum, S. & Koes, B.W. (2010). Effectiveness of Interventions of Specific Complaints of the Arm, Neck, and/or Shoulder: 3 Musculoskeletal Disorders of the Hand. An Update. Archives of Physical Medicine and Rehabilitation, 91(2), 298-314. Husson, E.C., Ribbers, G.M., Willemse - van Son, A.H.P., Verhagen, A.P. & Stam, H.J. (2010). Prognosis of six-month functioning after moderate to severe traumatic brain injury: a systematic review of prospective cohort studies. Journal of Rehabilitation Medicine, 42(5), 425-436. Kamper, SJ, Maher, CG, Hancock, MJ, Koes, B.W., Croft, PR & Hay, E (2010). Treatment-based subgroups of low back pain: A guide to appraisal of research studies and a summary of current evidence. Best Practice & Research in Clinical Rheumatology, 24(2), 181-191. Keijsers, E., Feleus, A., Miedema, H.S., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2010). Psychosocial factors predicted nonrecovery in both specific and nonspecific diagnoses at arm, neck, and shoulder. Journal of Clinical Epidemiology, 63(12), 1370-1379. Kerkhof, J.M., Bierma-Zeinstra, S.M.A., Castano Betancourt, M.C., Maat, M.P.M. de, Hofman, A., Pols, H.A.P., Rivadeneira Ramirez, F., Witteman, J.C.M., Uitterlinden, A.G. & Meurs, J.B.J. van (2010). Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Annals of the Rheumatic Diseases, 69(11), 1976-1982. Keuken, D.G., Haafkens, J.A., Mohrs, J, Klazinga, N.S. & Bindels, P.J.E. (2010). Evaluating the effectiveness of an educational and feedback intervention aimed at improving consideration of sex differences in guideline development. Quality & Safety in Health Care, 19(6). Koes, B.W., Tulder, M. van, Lin, CWC, Macedo, LG, McAuley, J & Maher, C (2010). An updated overview of clinical guidelines for the management of non-specific low back pain in primary care. European Spine Journal, 19(12), 2075-2094. Krul, M., Wouden, J.C. v.d., Schellevis, F.G., Suijlekom-Smit, L.W.A. van & Koes, B.W. (2010). Acute non-traumatic hip pathology in children: incidence and presentation in family practice. Family Practice, 27(2), 166-170. Krul, M., Wouden, J.C. van der, Schellevis, F.G., Suijlekom-Smit, L.W.A. van & Koes, B.W. (2010). Nursemaid's elbow: its diagnostic clues and preferred means of reduction. Journal of Family Practice, 59(1), E5-E7. 272

Kuijper, G de, Hoekstra, P, Visser, F., Scholte, F.A., Penning, C. & Evenhuis, H.M. (2010). Use of antipsychotic drugs in individuals with intellectual disability (ID) in the Netherlands: prevalence and reasons for prescription. Journal of Intellectual Disability Research, 54, 659-667. Lin, CWC, Taylor, D., Bierma-Zeinstra, S.M.A. & Maher, CG (2010). Exercise for Osteoarthritis of the Knee. Physical Therapy, 90(6), 839-842. Logghe, I.H.J., Verhagen, A.P., Rademaker, ACHJ, Bierma-Zeinstra, S.M.A., Rossum, E.F.C. van, Faber, M.J. & Koes, B.W. (2010). The effects of Tai Chi on fall prevention, fear of falling and balance in older people: A meta-analysis. Preventive Medicine, 51(3-4), 222-227. Maarsingh, OR, Dros, J., Schellevis, F.G., Weert, H.C., Bindels, P.J. & Horst, HE van der (2010). Dizziness reported by elderly patients in family practice: prevalence, incidence, and clinical characteristics. BMC Family Practice, 11. Mensch, S.M. & Penning, C. (2010). Watanabe K, Lenke LG, Daubs MD, et al. Is spine deformity surgery in patients with spastic cerebral palsy truly beneficial? Spine 2009; 34: 2222-32. Spine, 35(14), E621-E621. Mergler, S., Lobker, B.S.J., Evenhuis, H.M. & Penning, C. (2010). Feasibility of quantitative ultrasound measurement of the heel bone in people with intellectual disabilities. Research in Developmental Disabilities, 31(6), 1283-1290. Middelkoop, M. van, Rubinstein, SM, Verhagen, A.P., Ostelo, RW, Koes, B.W. & Tulder, M.W. van (2010). Exercise therapy for chronic nonspecific low-back pain. Best Practice & Research in Clinical Rheumatology, 24(2), 193-204. Mohangoo, A.D., Koning, H.J. de, Groen, E. de, Wouden, J.C. van der, Jaddoe, V.W.V.K., Moll, H.A., Hofman, A., Mackenbach, J.P., Jongste, J.C. de & Raat, H. (2010). A comparison of parent-reported wheezing of shortness of breath among infants as assessed bij questonnaire and physician-interview: The Generation R Study. Pediatric Pulmonology, 45, 500-507. Oei, E.H.G., Koster, I.M., Hensen, JHJ, Boks, S.S., Wagemakers, H.P.A., Koes, B.W., Vroegindeweij, D., Bierma-Zeinstra, S.M.A. & Hunink, M.G.M. (2010). MRI follow-up of conservatively treated meniscal knee lesions in general practice. European Radiology, 20(5), 1242-1250. Olieman, J.F., Penning, C., IJsselstijn, H., Escher, J.C., Joosten, K.F.M., Hulst, J.M. & Tibboel, D. (2010). Enteral nutrition in children with short-bowel syndrome: current evidence and recommendations for the clinician. Journal of the American Dietetic Association, 110, 420-426. Olieman, J.F., Poley, M.J., Gischler, S.J., Penning, C., Escher, J.C., Hoonaard, T.L. van den, Goudoever, J.B. van, Bax, N.M.A., Tibboel, D. & Meijers-IJsselstijn, H. (2010). Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth, and nutrition. Journal of Pediatric Surgery, 45, 490-498. Paulis, W.D., Evers, M.S. & Wouden, J.C. van der (2010). Re: does patient feedback improve the consultation skills of general practice trainees? Medical Education, 44(8), 845-845. Pijpers, M.A.M., Bongers, MEJ, Benninga, M.A. & Berger, M.Y. (2010). Functional Constipation in Children: A Systematic Review on Prognosis and Predictive Factors. Journal of Pediatric Gastroenterology and Nutrition, 50(3), 256-268. Ponsioen, B.P. (2010). BODE- of ADO-index bij eerstelijns prognosebepaling COPD. Huisarts en Wetenschap, 53(2), 72. Ponsioen, B.P. (2010). De functionele toestand bij meer ernstig COPD. Huisarts en Wetenschap, 53(2), 72. Ponsioen, B.P. (2010). Een rookvrije toekomst gloort in zuidwest Nederland. Huisarts en Wetenschap, 53(8), 412. Ponsioen, B.P. (2010). Het paradoxale effect van roken bij COPD-medicatie. Huisarts en Wetenschap, 53(6), 297. Ponsioen, B.P. (2010). Perceptie en therapietrouw bij nieuwe astmamedicatie. Huisarts en Wetenschap, 53(4), 186. Ponsioen, B.P. (2010). Smalle evidence base voor farmacologische behandeling van COPD? Huisarts en Wetenschap, 53(3), 126. Ponsioen, B.P. (2010). Trouwe placebogebruikers leven langer. Huisarts en Wetenschap, 53(9), 460. Ponsioen, B.P. (2010). Zorgbehoefte cognitief niet beperkte bejaarden duurt betrekkelijk kort. Huisarts en Wetenschap, 53(7), 353. Raaij, T.M. van, Reijman, M., Brouwer, R.W., Bierma-Zeinstra, S.M.A. & Verhaar, J.A.N. (2010). Medial Knee Osteoarthritis Treated by Insoles or Braces: A Randomized Trial. Clinical Orthopaedics & Related Research, 468(7), 1926-1932. Razmjou, RG, Willemsen, S.P., Koning, S., Oranje, A.P., Schellevis, F & Wouden, J.C. van der (2010). Oorzaak regionale verschillen incidentie impetigo onopgehelderd. Infectieziekten-Bulletin. Rieken, R., Calis, E.A.C., Tibboel, D., Evenhuis, H.M. & Penning, C. (2010). Validation of skinfold measurements and bioelectrical impedance analysis in children with severe cerebral palsy: A review. Clinical Nutrition, 29(2), 217-221. Rijn, R.M. van, Huisstede, B.M.A., Koes, B.W. & Burdorf, A. (2010). Associations between work-related factors and specific disorders of the shoulder - a systematic review of the literature. Scandinavian Journal of Work Environment & Health, 36(3), 189-201. 273

Rijn, R.M. van, Ochten, J.M. van, Luijsterburg, P.A.J., Middelkoop, M. van, Koes, B.W. & Bierma-Zeinstra, S.M.A. (2010). Effectiveness of additional supervised exercises compared with conventional treatment alone in patients with acute lateral ankle sprains: systematic review. British Medical Journal, 341. Roelofs, P.D.D.M., Bierma-Zeinstra, S.M.A., Poppel, M.N.M. van, Mechelen, W. van, Koes, B.W. & Tulder, M.W. van (2010). Cost-Effectiveness of Lumbar Supports for Home Care Workers With Recurrent Low Back Pain An Economic Evaluation Alongside a Randomized-Controlled Trial. Spine, 35(26), E1619-E1626. Roelofs, P.D.D.M., Poppel, M.N.M. van, Bierma-Zeinstra, S.M.A. & Mechelen, W. van (2010). Determinants of the intention for using a lumbar support among home care workers with recurrent low back pain. European Spine Journal, 19(9), 1502-1507. Rubinstein, SM, Middelkoop, M. van, Kuijpers, T, Ostelo, R, Verhagen, A.P., Boer, MR de, Koes, B.W. & Tulder, M.W. van (2010). A systematic review on the effectiveness of complementary and alternative medicine for chronic non-specific low-back pain. European Spine Journal, 19(8), 1213-1228. Runhaar, J. & Wouden, J.C. v.d. (2010). Effect of Oral Glucosamine on Pain-Related Disability in Patients With Chronic Low Back Pain. Jama - Journal of the American Medical Association, 304(15), 1673-1673. Schellingerhout, J.M. & Verhagen, A.P. (2010). Letter to the Editor concerning "Development of a clinical prediction rule to identify patients with neck pain likely to benefit from cervical traction and exercise" by Raney N et al. (2009) Eur Spine J 18:382-391. European Spine Journal, 19(5), 833-833. Schellingerhout, J.M., Heymans, M.W., Verhagen, A.P., Lewis, M, Vet, H.C.W. & Koes, B.W. (2010). Prognosis of Patients With Nonspecific Neck Pain Development and External Validation of a Prediction Rule for Persistence of Complaints. Spine, 35(17), E827-E835. Schellingerhout, J.M. (2010). Beslisregels bij klachten bewegingsapparaat. Huisarts en Wetenschap, 53(11), 582. Schepper, E.I.T. de, Damen, J., Meurs, J.B.J. van, Ginai, A.Z., Popham, M, Hofman, A., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2010). The Association Between Lumbar Disc Degeneration and Low Back Pain The Influence of Age, Gender, and Individual Radiographic Features. Spine, 35(5), 531-536. Schoonloo-Karels, C.H., Bierma-Zeinstra, S.M.A., Verhagen, A.P., Koes, B.W. & Burdorf, A. (2010). Sickness absence in patients with arm, neck and shoulder complaints presenting in physical therapy practice: 6 months follow-up. Manual Therapy, 15(5), 476-481. Schouten, B.W.V., Bohnen, A.M., Groeneveld, F.P.M.J., Dohle, G.R., Thomas, S. & Bosch, J.L.H.R. (2010). Erectile Dysfunction in the Community: Trends over Time in Incidence, Prevalence, GP Consultation and Medication Use-the Krimpen Study: Trends in ED. Journal of Sexual Medicine, 7(7), 2547-2553. Seventer, R Van, Vos, C.J., Meerding, W, Mear, I, Gal, M Le, Bouhassira, D & Huygen, F.J.P.M. (2010). Linguistic validation of the DN4 for use in international studies. European Journal of Pain-London, 14(1), 58-63. Spee, L.A.A., Madderom, M.B., Pijpers, M.A.M., Leeuwen, Y. van & Berger, M.Y. (2010). Association Between Helicobacter pylori and Gastrointestinal Symptoms in Children. Pediatrics, 125(3), E651-E669. Spee, L.A.A., Hurk, A.P.J.M. van den, Leeuwen, Y. van, Benninga, M.A., Bierma-Zeinstra, S.M.A., Passchier, J. & Berger, M.Y. (2010). Childhood abdominal pain in primary care: design and patient selection of the HONEUR abdominal pain cohort. BMC Family Practice, 11. Stanton, TR, Hancock, MJ, Maher, CG & Koes, B.W. (2010). Critical Appraisal of Clinical Prediction Rules That Aim to Optimize Treatment Selection for Musculoskeletal Conditions. Physical Therapy, 90(6), 843-854. 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EMC NIHES-03-30-01 - Implementation of diagnostic and interventional imaging technology Programme in brief design The research program focuses on the implementation of new techniques used for diagnostic and interventional imaging technology. Specific topics of interest within the program are Magnetic Resonance (MR) technology (including interventional MRI), Multidetector Spiral Computed Tomography (MSCT), and interventional radiology. Projects involve high-speed MRangiography of coronary/carotid arteries and veins, MRI of organ perfusion (e.g. brain perfusion in stroke, perfusion in transplant organs), real-time imaging of catheter and needle manipulations, MRI-temperature mapping (to monitor thermo-ablative treatment of localized heat-induced gene therapy), and percutaneous treatment of vascular disease. Emphasis is placed on carotid artery stenting, percutaneous treatment of aortic aneurysmal disease in elective and acute situations, creation of Transjugular Intrahepatic Portosystemic Shunts (TIPS), thermo-ablation with laser or focused percutaneous ultrasound, and non-invasive coronary angiography with MSCT. A parallel line of investigation implements molecular imaging techniques developed in EMC NIHES-03-30-03. Although we principally use MRI (3T) imaging techniques, the potential exists to use MSCT for molecular imaging for projects for which this would be advantageous. Possible future directions include quantification of tumor perfusion and angiogenesis, heat-induced local drug delivery or gene therapy, and/or applying heat- sensitive contrast agents. There is extensive collaboration with clinical groups within Erasmus MC including the Departments of Internal Medicine, Pediatrics, Vascular Surgery, Cardiology, Neurology, and Surgical Oncology and with Erasmus MC basic science groups including the Department of Experimental Cardiology/Thorax Center and the Department of Medical Informatics Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot cardiology 0,32 0 0 0 0,32 epidemiology 0,16 0 0 0 0,16 neurosciences 0,2 0 0 0 0,2 pediatrics 0,1 0 0 0 0,1 pediatrics-cardiology 0,3 0 0 0 0,3 pediatrics-ic/n 0,2 0 0 0 0,2 pediatrics-other 0,06 0 0,72 0 0,78 pediatrics-pulmonology 0,2 0 0 0 0,2 radiology 8,62 0,1 0 0 8,72 Total 10,16 0,1 0,72 0 10,98 3 0 0 3 74 3 0 80 Thesis Dudink, J. (2010, september 01). Diffusion weighted imaging of the neonatal brain. EUR (238 pag.) (Rotterdam: Print Partners Ipskamp). Prom./coprom.: Prof. Dr. J.B. van Goudoever, dr. P. Govaert & Dr. M.H. Lequin. Groen, H.C. (2010, november 10). Atherosclerotic plaque and shear stress in carotid arteries. EUR (177 pag.). Prom./coprom.: Prof. Dr. Ir. A.F.W. van der Steen, Dr. Ir. J.J. Wentzel & Dr. A. van der Lugt. Weustink, A.C. (2010, december 15). CT coronary angiography in clinical practice. EUR (269 pag.). Prom./coprom.: Prof.Dr. P.J. de Feyter, Prof. Dr. G.P. Krestin & Dr. N.R.A. Mollet. Artikel/Letter to the editor Boer, R. de, Vrooman, H.A., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B., Lugt, A. van der & Niessen, W.J. (2010). Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods. Neuroimage, 51(3), 1047-1056. Bonati, LH, Jongen, LM, Haller, S, Flach, H.Z., Dobson, J., Nederkoorn, P.J., Macdonald, S, Gaines, P.A., Waaijer, A, Stierli, P, Jager, HR, Lyrer, PA, Kappelle, L.J., Wetzel, SG, Lugt, A. van der, Mali, WP, Brown, M.M., Worp, H.B. van der & Engelter, ST (2010). New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the International Carotid Stenting Study (ICSS). Lancet Neurology, 9(4), 353-362. Cademartiri, F., Maffei, E., Palumbo, A., Seitun, S, Martini, C, Tedeschi, C, Grutta, L. la, Midiri, M., Weustink, A.C., Mollet, N.R. & Krestin, G.P. (2010). Coronary calcium score and computed tomography coronary angiography in high-risk asymptomatic subjects: assessment of diagnostic accuracy and prevalence of non-obstructive coronary artery disease. European Radiology, 20(4), 846-854. Cademartiri, F., Maffei, E., Palumbo, A., Martini, C, Seitun, S, Tedeschi, C, Rosa, R De, Arcadi, T, Salamone, I, Blandino, A, Weustink, A.C., Mollet, N.R., Feyter, P.J. de & Krestin, G.P. (2010). Diagnostic accuracy of computed tomography coronary angiography in patients with a zero calcium score. European Radiology, 20(1), 81-87. Cademartiri, F., Runza, G., Palumbo, A., Maffei, E., Martini, C, McFadden, E, Somers, P, Knaapen, M, Verheye, S., Weustink, A.C., Mollet, N.R., Feyter, P.J. de, Hamers, R. & Bruining, N. (2010). Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration. Journal of Cardiovascular Medicine, 11(5), 337-344. 276

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Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Heijer, T. den, Hofman, A., Niessen, W.J., Lugt, A. van der, Koudstaal, P.J. & Breteler, M.M.B. (2010). Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of Aging, 31(3), 378-386. Ikram, M.A., Luijendijk, H.J., Vernooij, M.W., Hofman, A., Niessen, W.J., Lugt, A. van der, Tiemeier, H.W. & Breteler, M.M.B. (2010). Vascular Brain Disease and Depression in the Elderly. Epidemiology, 21(1), 78-81. Jong, K. de, Nio, CY, Hermans, J.J., Dijkgraaf, MG, Gouma, D.J., Eijck, C.H.J. van, Heel, E van, Klass, G, Fockens, P. & Bruno, M.J. (2010). High Prevalence of Pancreatic Cysts Detected by Screening Magnetic Resonance Imaging Examinations. Clinical Gastroenterology and Hepatology, 8(9), 806-811. 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Palazzuoli, A, Cademartiri, F., Geleijnse, M.L., Meijboom, B., Pugliese, F., Soliman, O.I.I., Calabro, A, Nuti, R. & Feyter, P.J. de (2010). Left ventricular remodelling and systolic function measurement with 64 multi-slice computed tomography versus second harmonic echocardiography in patients with coronary artery disease: A double blind study. European Journal of Radiology, 73(1), 82-88. Pattynama, P.M.T. (2010). Legal aspects of cross-border teleradiology. European Journal of Radiology, 73(1), 26-30. Paulides, M.M., Bakker, J.F., Linthorst, M., Zee, J.A. van der, Rijnen, Z., Neufeld, E, Pattynama, P.M.T., Jansen, P.P., Levendag, P.C. & Rhoon, G.C. van (2010). The clinical feasibility of deep hyperthermia treatment in the head and neck: new challenges for positioning and temperature measurement. Physics in Medicine and Biology, 55(9), 2465-2480. Poels, M.M.F., Vernooij, M.W., Ikram, M.A., Hofman, A., Krestin, G.P., Lugt, A. van der & Breteler, M.M.B. (2010). Prevalence and Risk Factors of Cerebral Microbleeds An Update of the Rotterdam Scan Study. Stroke, 41(10), S103-S106. Rijnsburger, A.J., Obdeijn, A.I.M., Kaas, R., Tilanus-Linthorst, M.M.A., Boetes, C., Loo, CE, Wasser, M.N.J.M., Bergers, E, Kok, T. de, Muller, S.H., Peterse, H., Tollenaar, R.A.E.M., Hoogerbrugge, N., Meijer, S, Bartels, C.C.M., Seynaeve, C., Hooning, M.J., Kriege, M., Schmitz, P.I.M., Oosterwijk, J.C., Koning, H.J. de, Rutgers, EJT & Klijn, J.G.M. (2010). BRCA1-Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study. Journal of Clinical Oncology, 28(36), 5265-5273. Robroeks, C.M.H.H.T., Roozeboom, M.H., Jong, P.A. de, Tiddens, H.A.W.M., Jobsis, Q., Hendriks, H.J., Yntema, J.B.L., Brackel, H.L., Gent, R. van, Robben, S. & Dompeling, E. (2010). Structural lung changes, lung function and non-invasive inflammatory markers in cystic fibrosis. Pediatric Allergy and Immunology, 21, 493-500. Saba, L, Potters, F, Lugt, A. van der & Mallarini, G (2010). Imaging of the Fibrous Cap in Atherosclerotic Carotid Plaque. Cardiovascular & Interventional Radiology, 33(4), 681-689. Sardanelli, F, Hunink, M.G.M., Gilbert, FJ, Leo, G. & Krestin, G.P. (2010). Evidence-based radiology: why and how? European Radiology, 20(1), 1-15. Schepper, E.I.T. de, Damen, J., Meurs, J.B.J. van, Ginai, A.Z., Popham, M, Hofman, A., Koes, B.W. & Bierma-Zeinstra, S.M.A. (2010). The Association Between Lumbar Disc Degeneration and Low Back Pain The Influence of Age, Gender, and Individual Radiographic Features. Spine, 35(5), 531-536. Schultz, C.J., Moelker, A., Piazza, N., Tzikas, A., Otten, A, Nuis, R.J.M., Neefjes, LA, Geuns, R.J.M. van, Feyter, P.J. de, Krestin, G.P., Serruys, P.W.J.C. & Jaegere, P.P.T. de (2010). Three dimensional evaluation of the aortic annulus using multislice computer tomography: are manufacturer's guidelines for sizing for percutaneous aortic valve replacement helpful? European Heart Journal, 31(7), 849-856. Seelaar, H., Klijnsma, K.Y., Koning, I. de, Lugt, A. van der, Chiu, W.Z., Azmani, A., Rozemuller, AJM & Swieten, J.C. van (2010). Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration. Journal of Neurology, 257(5), 747-753. Smit, A.E., Geest, J.N. van der, Metselaar, M., Lugt, A. van der, Werf, F. van der & Zeeuw, C.I. de (2010). Long-term changes in cerebellar activation during functional recovery from transient peripheral motor paralysis. Experimental Neurology, 226(1), 33-39. Smits, M., Dippel, D.W.J., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Rijssel, DA van, Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2010). Minor Head Injury: CT-based Strategies for Management - A Cost-effectiveness Analysis. Radiology, 254(2), 532-540. Tholen, A.T.R., Monye, C. de, Genders, T.S.S., Buskens, E., Dippel, D.W.J., Lugt, A. van der & Hunink, M.G.M. (2010). Suspected Carotid Artery Stenosis: Cost-effectiveness of CT Angiography in Work-up of Patients with Recent TIA or Minor Ischemic Stroke. Radiology, 256(2), 585-597. Tiddens, H.A.W.M., Donaldson, S.H., Rosenfeld, M. & Pare, P.D. (2010). Cystic Fibrosis lung disease starts in the small airways: can we treat it more effectively? Pediatric Pulmonology, 45, 107-117. Veenma, D.C.M., Beurskens, L.W.J.E., Douben, J.C.W., Eussen, B.H.J., Noomen, P., Govaerts, L.C.P., Grijseels, E.W.M., Lequin, M.H., Krijger, R.R. de, Tibboel, D., Klein, A. de & Opstal, D. van (2010). Comparable Low-Level Mosaicism in Affected and Non Affected Tissue of a Complex CDH Patient. PLoS One, 5(12), e15348. Verkerk, A.J.M.H., Schot, R., Waterschoot, L. van, Douben, J.C.W., Poddighe, P.J., Lequin, M.H., Vries, L.S. de, Terhal, P, Hahnemann, JMD, Coo, I.F.M. de, Wit, M.C.Y. de, Wafelman, L.S., Garavelli, L, Dobyns, WB, Spek, P.J. van der, Klein, A. de & Mancini, G.M.S. (2010). Unbalanced der(5)t(5;20) Translocation Associated With Megalencephaly, Perisylvian Polymicrogyria, Polydactyly and Hydrocephalus. American Journal of Medical Genetics Part A, 152A(6), 1488-1497. Voort van Zyp, N.C.M.G. van der, Prevost, J.G.H.G., Holt, B. van der, Braat, C., Klaveren, R.J. van, Pattynama, P.M.T., Levendag, P.C. & Nuyttens, J.J. (2010). Quality of life after stereotactic radiotherapy forstage I non-small-cell lung cancer. International Journal of Radiation Oncology Biology Physics, 77(1), 31-37. Voort van Zyp, N.C.M.G. van der, Holt, B. van der, Klaveren, R.J. van, Pattynama, P.M.T., Maat, A. van de & Nuyttens, J.J. (2010). Stereotactic body radiotherapy using real-time tumor tracking in octogenarians with non-small cell lung cancer. Lung Cancer, 69(3), 296-301. 279

Vrolijk, J.M., Noord, D. van, Verhagen, H.J.M., Pattynama, P.M.T. & Mensink, P.B. (2010). A giant antral ulceration evoked by a rare cause of single-vessel chronic GI ischemia. Gastrointestinal Endoscopy, 72(1), 211-213. Vukadinovic, D., Walsum, T. van, Manniesing, R., Rozie, S., Hameeteman, K., Weert, T.T. de, Lugt, A. van der & Niessen, W.J. (2010). Segmentation of the Outer Vessel Wall of the Common Carotid Artery in CTA. IEEE Transactions on Medical Imaging, 29(1), 65-76. Werkhoven, JM van, Cademartiri, F., Seitun, S, Maffei, E., Palumbo, A., Martini, C, Tarantini, G, Kroft, LJ, Roos, A. de, Weustink, A.C., Jukema, J.W., Ardissino, D., Mollet, N.R., Schuijf, JD & Bax, J.J. (2010). Diabetes: Prognostic Value of CT Coronary Angiography-Comparison with a Nondiabetic Population. Radiology, 256(1), 83-92. Werkhoven, JM van, Boer, S.M., Schuijf, JD, Cademartiri, F., Maffei, E., Jukema, J.W., Boogers, MJ, Kroft, LJ, Roos, A. de & Bax, J.J. (2010). Impact of Clinical Presentation and Pretest Likelihood on the Relation Between Calcium Score and Computed Tomographic Coronary Angiography. American Journal of Cardiology, 106(12), 1675-1679. Wessels, M.W., Kuchinka, B., Heydanus, R., Smit, B.J., Dooijes, D., Krijger, R.R. de, Lequin, M.H., Jong, E.M. de, Husen, M, Willems, P..J. & Casey, B. (2010). Polyalanine expansion in the ZIC3 gene leading to X-linked heterotaxy with VACTERL association: a new polyalanine disorder? Journal of Medical Genetics, 47(5), 351-355. Weustink, A.C., Mollet, N.R., Neefjes, LA, Meijboom, W.B., Galema, T.W., Mieghem, C.A.G. van, Kyrzopoulous, S, Eu, RN, Nieman, K., Cademartiri, F., Geuns, R.J.M. van, Boersma, E., Krestin, G.P. & Feyter, P.J. de (2010). Diagnostic Accuracy and Clinical Utility of Noninvasive Testing for Coronary Artery Disease. Annals of Internal Medicine, 152(10), 630-639. Wijkerslooth, TR de, Haan, MC de, Stoop, E.M., Deutekom, M, Fockens, P., Bossuyt, P.M.M., Thomeer, M.G.J., Ballegooijen, M. van, Essink-Bot, M.L., Leerdam, M.E. van, Kuipers, E.J., Dekker, E & Stoker, J.. (2010). Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial. BMC Gastroenterology, 10. Winkel, M.L. te, Sluis, I.M. van der, Lequin, M.H., Pieters, R. & Heuvel-Eibrink, M.M. van den (2010). Letter to editor in response to "Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia" by Mussa et al. Bone, 47, 835-836. Winkel, M.L. te, Lequin, M.H., Bruyn, J.R. de, Ven, C.P. van de, Krijger, R.R. de, Pieters, R. & Heuvel-Eibrink, M.M. van den (2010). Self-limiting sternal tumors of childhood (SELSTOC). Pediatric Blood & Cancer, 55, 81-84. Wit, M.C.Y. de, Schippers, HM, Coo, I.F.M. de, Arts, W.F.M., Lequin, M.H., Brooks, A, Visser, G.H. & Mancini, G.M.S. (2010). Absence epilepsy and periventricular nodular heterotopia. Seizure, 19(7), 450-452. Wit, M.C.Y. de, Coo, I.F.M. de, Schot, R., Hoogeboom, A.J.M., Lequin, M.H., Verkerk, A.J.M.H. & Mancini, G.M.S. (2010). Periventricular Nodular Heterotopia and Distal Limb Deficiency: A Recurrent Association. American Journal of Medical Genetics Part A, 152A(4), 954-959. Part of book - abstract Dijkshoorn, M.L. & Hakkert, M. (2010). Post processing. In M Hakkert, G Tempelman, T Dam, J Dol-Jansen & S GeertvanGemeren (Eds.), Computer tomography: technology, research and radiation safety (pp. 163-184). Amsterdam: Elsevier. Nieman, K. & Dijkshoorn, M.L. (2010). Clinical significance of second-generation dual-source CT. In K Kazuhisa (Ed.), MOOK3: cardiac imaging. PIDO. 280

EMC NIHES-03-30-02 - Assessment of diagnostic and interventional imaging technology Programme in brief design The research program focuses on the assessment of diagnostic imaging technology and image-guided therapies. The assessment includes clinical efficacy, patient outcomes, and costs-effectiveness. There is a special interest in the assessment of new imaging technology for cardiovascular disease, including such techniques as magnetic resonance angiography, computed tomography angiography, imaging of vulnerable plaque, and molecular imaging. The research methods employed are from clinical epidemiology, decision sciences, and medical technology assessment. The methodological research of the group focuses on developing the methods and study design for evaluating diagnostic imaging technology. The long-term goal of the program is to provide relevant information for implementing evidence-based clinical services.the program is a collaborative effort between the Depts of Radiology and Epidemiology & Biostatistics. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 0,06 0 0 0 0,06 radiology 1,65 0,43 0 0 2,08 radiotherapy 0,38 0 0 0 0,38 Total 2,09 0,43 0 0 2,52 1 0 0 1 17 0 0 18 Thesis Berg- de Lange, C. van den (2010, december 09). The contribution of acupuncture and moxibustion to healthcare an evidencebased approach. EUR. Prom./coprom.: Prof. Dr. M.G.M. Hunink & Dr. J.J. Duvekot. Artikel/Letter to the editor Berg, I. van den, Kaandorp, G.C., Bosch, J.L., Duvekot, J.J., Arends, L.R. & Hunink, M.G.M. (2010). Cost-effectiveness of breech version by acupuncture-type interventions on BL 67, including moxibustion, for women with a breech foetus at 33 weeks gestation: a modelling approach. Complementary Therapies in Medicine, 18(2), 67-77. Elias-Smale, S.E., Odink, A.E., Wieberdink, R.G., Hofman, A., Hunink, M.G.M., Krestin, G.P., Koudstaal, P.J., Breteler, M.M.B., Lugt, A. van der & Witteman, J.C.M. (2010). Carotid, aortic arch and coronary calcification are related to history of stroke: The Rotterdam Study. Atherosclerosis, 212(2), 656-660. Elias-Smale, S.E., Proenca, RV, Koller, M.T., Kavousi, M., Rooij, F.J.A. van, Hunink, M.G.M., Steyerberg, E.W., Hofman, A., Oudkerk, M.. & Witteman, J.C.M. (2010). Coronary Calcium Score Improves Classification of Coronary Heart Disease Risk in the Elderly The Rotterdam Study. Journal of the American College of Cardiology, 56(17), 1407-1414. Ferket, B.S., Kempen, B.J.H. van & Janssens, A.C.J.W. (2010). Assessing Predictive Performance Beyond the Framingham Risk Score. Jama - Journal of the American Medical Association, 303(14), 1368-1368. Ferket, B.S., Colkesen, EB, Visser, J.J., Spronk, S., Kraaijenhagen, RA, Steyerberg, E.W. & Hunink, M.G.M. (2010). Systematic Review of Guidelines on Cardiovascular Risk Assessment Which Recommendations Should Clinicians Follow for a Cardiovascular Health Check? Archives of Internal Medicine, 170(1), 27-40. Genders, T.S.S., Pugliese, F., Mollet, N.R., Meijboom, W.B., Weustink, A.C., Mieghem, C.A.G. van, Feyter, P.J. de & Hunink, M.G.M. (2010). Incremental value of the CT coronary calcium score for the prediction of coronary artery disease. European Radiology, 20(10), 2331-2340. Groot Koerkamp, B., Weinstein, M.C., Stijnen, T., Heijenbrok-Kal, M.H. & Hunink, M.G.M. (2010). Uncertainty and Patient Heterogeneity in Medical Decision Models. Medical Decision Making, 30(2), 194-205. Groot Koerkamp, B., Spronk, S., Stijnen, T. & Hunink, M.G.M. (2010). Value of Information Analyses of Economic Randomized Controlled Trials: The Treatment of Intermittent Claudication. Value in Health, 13(2), 242-250. Grootenboer, N., Sambeek, M.R.H.M. van, Arends, L.R., Hendriks, J.M., Hunink, M.G.M. & Bosch, J.L. (2010). Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm. British Journal of Surgery, 97(8), 1169-1179. Hassan, C, Pickhardt, PJ, Giulio, E Di, Hunink, M.G.M., Zullo, A & Nardelli, BB (2010). Value-of-Information Analysis to Guide Future Research in the Management of the Colorectal Malignant Polyp. Diseases of the Colon & Rectum, 53(2), 135-142. Mihaescu, R., Zitteren, M. van, Hoek, M. van der, Sijbrands, E.J.G., Uitterlinden, A.G., Witteman, J.C.M., Hofman, A., Hunink, M.G.M., Duijn, C.M. van & Janssens, A.C.J.W. (2010). Improvement of Risk Prediction by Genomic Profiling: Reclassification Measures Versus the Area Under the Receiver Operating Characteristic Curve. American Journal of Epidemiology, 172(3), 353-361. Odink, A.E., Lugt, A. van der, Hofman, A., Hunink, M.G.M., Breteler, M.M.B., Krestin, G.P. & Witteman, J.C.M. (2010). Risk factors for coronary, aortic arch and carotid calcification; The Rotterdam Study. Journal of Human Hypertension, 24(2), 86-92. Oei, E.H.G., Koster, I.M., Hensen, JHJ, Boks, S.S., Wagemakers, H.P.A., Koes, B.W., Vroegindeweij, D., Bierma-Zeinstra, S.M.A. & Hunink, M.G.M. (2010). MRI follow-up of conservatively treated meniscal knee lesions in general practice. European Radiology, 20(5), 1242-1250. 281

Sardanelli, F, Hunink, M.G.M., Gilbert, FJ, Leo, G. & Krestin, G.P. (2010). Evidence-based radiology: why and how? European Radiology, 20(1), 1-15. Smits, M., Dippel, D.W.J., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, DR, Rijssel, DA van, Hofman, PAM, Twijnstra, A., Tanghe, H.L.J. & Hunink, M.G.M. (2010). Minor Head Injury: CT-based Strategies for Management - A Cost-effectiveness Analysis. Radiology, 254(2), 532-540. Spronk, S., Ridder, M.A.J. de & Lesaffre, E.M.E.H. (2010). Primary End-Point Error Response. Radiology, 256(3), 1011-1012. Tholen, A.T.R., Monye, C. de, Genders, T.S.S., Buskens, E., Dippel, D.W.J., Lugt, A. van der & Hunink, M.G.M. (2010). Suspected Carotid Artery Stenosis: Cost-effectiveness of CT Angiography in Work-up of Patients with Recent TIA or Minor Ischemic Stroke. Radiology, 256(2), 585-597. 282

EMC NIHES-03-30-03 - Development of acquisition and processing techniques for diagnostic imaging Programme in brief design The general goal of this research program is to investigate and validate new diagnostic and therapeutic imaging techniques for both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). We focus on image acquisition, processing and segmentation of three (or higher) dimensional image data in order to be able to enhance patient care. The main research focuses are the improvement of existing and development new computerized techniques for the segmentation of high-dimensional diagnostic images. Specific goals are (a) to increase the outcome of image segmentation techniques, (b) to develop new ways of visualizing high-dimensional data sets by combining existing techniques (surface and volume rendering) with newly developed methods (virtual reality), and (c) to improve user-interfaces and develop automated procedures to assist the end-user with the post-processing, segmentation and visualization of radiological image data. Furthermore, image registration, data fusion and measurements in diagnostic images will be developed and validated. We are also interested in optimizing acquisition protocols so that region-of-interest imaging makes use of the maximum capabilities of our imaging systems. This will benefit both diagnosis and therapeutical monitoring tasks. The initial target is enhanced direct visualization of the epicardial coronary anatomy, by which we can establish the presence, site, severity, and/or status of coronary atherosclerotic disease. Further targets are assessment of ventricular function and characterization of atherosclerotic plaque composition. We will than use the optimized protocols to investigate the diagnostic possibilities and diagnostic accuracy of MR cardiac and coronary imaging and to determine the possible clinical indications for MR imaging of both native coronary artery disease and coronary bypass disease. Molecular Imaging is an area demanding international attention. Acquisition of information on the cellular and molecular level and subsequent analysis is expected to have a profound impact on the diagnosis, monitoring and treatment of diseases that have the potential of being redefined in terms of their characteristics genetic or molecular abnormalities. We are optimizing our imaging systems (with an emphasis on MRI) to provide near-cellular resolution and expect to move into animal studies soon Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot cardiology 0,03 0 0 0 0,03 medical informatics 3,89 4,55 0,25 1,81 10,5 nuclear medicine 0 0 0,25 0 0,25 radiology 6,45 6,18 0,5 1,81 14,94 Total 10,37 10,73 1 3,62 25,72 2 1 0 3 28 0 0 31 Thesis Isola, A.A. (2010, juni 18). Motion compensated iterative reconstruction for cardiac X-ray tomography. EUR (133 pag.). Prom./coprom.: Prof. Dr. W.J. Niessen & M Grass. Lijn, F. van der (2010, september 08). Automated atlas-based segmentation of brain structures in MR images. EUR (151 pag.). Prom./coprom.: Prof. Dr. W.J. Niessen & Dr. Ir. H.A. Vrooman. Schaap, M. (2010, december 15). Quantitative image analysis in cardiac CT angiography. EUR (171 pag.). Prom./coprom.: Prof. Dr. W.J. Niessen & Dr. T. van Walsum. Artikel/Letter to the editor Bernsen, M.R., Moelker, A.D., Wielopolski, P.A., Tiel, S.T. van & Krestin, G.P. (2010). Labelling of mammalian cells for visualisation by MRI. European Radiology, 20(2), 255-274. Boer, R. de, Vrooman, H.A., Ikram, M.A., Vernooij, M.W., Breteler, M.M.B., Lugt, A. van der & Niessen, W.J. (2010). Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods. Neuroimage, 51(3), 1047-1056. Chmarra, MK, Klein, S., Winter, JCF de, Jansen, F.W. & Dankelman, J (2010). Objective classification of residents based on their psychomotor laparoscopic skills. Surgical Endoscopy-Ultrasound and Interventional Techniques, 24(5), 1031-1039. Dzyubachyk, O., Cappellen, W.A. van, Essers, J., Niessen, W.J. & Meijering, H.W. (2010). Advanced Level-Set-Based Cell Tracking in Time-Lapse Fluorescence Microscopy. IEEE Transactions on Medical Imaging, 29(3), 852-867. Dzyubachyk, O., Essers, J., Cappellen, W.A. van, Baldeyron, C., Inagaki, A., Niessen, W.J. & Meijering, H.W. (2010). Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci. Bioinformatics, 26(19), 2424-2430. Giessen, A.G. van der, Toepker, MH, Donelly, PM, Bamberg, F, Schlett, CL, Raffle, C, Irlbeck, T, Lee, H., Walsum, T. van, Maurovich-Horvat, P, Gijsen, F.J.H., Wentzel, J.J. & Hoffmann, U. (2010). Reproducibility, Accuracy, and Predictors of Accuracy for the Detection of Coronary Atherosclerotic Plaque Composition by Computed Tomography An Ex Vivo Comparison to Intravascular Ultrasound. Investigative Radiology, 45(11), 693-701. Giessen, A.G. van der, Schaap, M., Gijsen, F.J.H., Groen, H.C., Walsum, T. van, Mollet, N.R., Dijkstra, J., Vosse, F.N. van de, Niessen, W.J., Feyter, P.J. de, Steen, A.F.W. van der & Wentzel, J.J. (2010). 3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study. International Journal of Cardiovascular Imaging, 26(7), 781-796. 283

Groen, H.C., Walsum, T. van, Rozie, S., Klein, S., Gaalen, K. van, Gijsen, F.J.H., Wielopolski, P.A., Beusekom, H.M.M. van, Crom, R. de, Verhagen, H.J.M., Steen, A.F.W. van der, Lugt, A. van der, Wentzel, J.J. & Niessen, W.J. (2010). Threedimensional registration of histology of human atherosclerotic carotid plaques to in-vivo imaging. Journal of Biomechanics, 43(11), 2087-2092. Heijer, T. den, Lijn, F. van der, Koudstaal, P.J., Hofman, A., Lugt, A. van der, Krestin, G.P., Niessen, W.J. & Breteler, M.M.B. (2010). A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline. Brain, 133, 1163-1172. Ikram, M.A., Vrooman, H.A., Vernooij, M.W., Heijer, T. den, Hofman, A., Niessen, W.J., Lugt, A. van der, Koudstaal, P.J. & Breteler, M.M.B. (2010). Brain tissue volumes in relation to cognitive function and risk of dementia. Neurobiology of Aging, 31(3), 378-386. Ikram, M.A., Luijendijk, H.J., Vernooij, M.W., Hofman, A., Niessen, W.J., Lugt, A. van der, Tiemeier, H.W. & Breteler, M.M.B. (2010). Vascular Brain Disease and Depression in the Elderly. Epidemiology, 21(1), 78-81. Isola, A.A., Grass, M & Niessen, W.J. (2010). Fully automatic nonrigid registration-based local motion estimation for motioncorrected iterative cardiac CT reconstruction. Medical Physics, 37(3), 1093-1109. Isola, A.A., Ziegler, A, Schafer, D, Kohler, T., Niessen, W.J. & Grass, M (2010). Motion compensated iterative reconstruction of a region of interest in cardiac cone-beam CT. Computerized Medical Imaging and Graphics, 34(2), 149-159. Kaijzel, EL, Heijningen, P.M. van, Wielopolski, P.A., Vermeij, M., Koning, G.A., Cappellen, W.A. van, Que, I., Chan, A.J.K., Dijkstra, J., Ramnath, N.W.M., Hawinkels, LJAC, Bernsen, M.R., Lowik, C.W.G.M. & Essers, J. (2010). Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice. Circulation Cardiovascular Imaging, 3(5), 567-577. Keevil, SF & Krestin, G.P. (2010). EMF directive still poses a risk to MRI research in Europe. Lancet (UK), 376(9747), 1124-1125. Kirisli, H.A., Schaap, M., Klein, S., Papadopoulou, S.L., Bonardi, M, Chen, C.H., Weustink, A.C., Mollet, N.R., Vonken, EJ, Geest, R.J. van der, Walsum, T. van & Niessen, W.J. (2010). Evaluation of a multi-atlas based method for segmentation of cardiac CTA data: a large-scale, multicenter, and multivendor study. Medical Physics, 37(12), 6279-6291. Krestin, G.P. (2010). Commoditization in Radiology: Threat or Opportunity? Radiology, 256(2), 338-342. Lo, P, Sporring, J, Ashraf, H, Pedersen, JJH & Bruijne, M. de (2010). Vessel-guided airway tree segmentation: A voxel classification approach. Medical Image Analysis, 14(4), 527-538. Manniesing, R., Schaap, M., Rozie, S., Hameeteman, K., Vukadinovic, D., Lugt, A. van der & Niessen, W. (2010). Robust CTA lumen segmentation of the atherosclerotic carotid artery bifurcation in a large patient population. Medical Image Analysis, 14(6), 759-769. Meijering, H.W. (2010). Neuron Tracing in Perspective. Cytometry Part A, 77A(7), 693-704. Montenegro Gouveia, S., Leslie, K., Kapitein, L.C., Buey, RM, Grigoriev, I, Wagenbach, M, Smal, I., Meijering, H.W., Hoogenraad, C.C., Wordeman, L, Steinmetz, MO & Akhmanova, A.S. (2010). In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends. Current Biology, 20(19), 1717-1722. Nout, E., Bouw, F.P., Veenland, J.F., Hop, W.C.J., Wal, K.G.H. van der, Mathijssen, I.M.J. & Wolvius, E.B. (2010). Three- Dimensional Airway Changes after Le Fort III Advancement in Syndromic Craniosynostosis Patients. Plastic and Reconstructive Surgery, 126(2), 564-571. Smal, I., Grigoriev, I, Akhmanova, A.S., Niessen, W.J. & Meijering, H.W. (2010). Microtubule Dynamics Analysis Using Kymographs and Variable-Rate Particle Filters. IEEE Transactions on Image Processing, 19(7), 1861-1876. Smal, I., Loog, M, Niessen, W. & Meijering, H.W. (2010). Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy. IEEE Transactions on Medical Imaging, 29(2), 282-301. Sorensen, L, Shaker, SB & Bruijne, M. de (2010). Quantitative Analysis of Pulmonary Emphysema Using Local Binary Patterns. IEEE Transactions on Medical Imaging, 29(2), 559-569. Stepanova, T., Smal, I., Haren, J. van, Akinci, U., Liu, Z., Miedema, M., Limpens, R, Ham, M. van, Reijden, M.I.J.A. van der, Poot, R.A., Grosveld, F.G., Mommaas, M, Meijering, H.W. & Galjart, N.J. (2010). History-Dependent Catastrophes Regulate Axonal Microtubule Behavior. Current Biology, 20(11), 1023-1028. Tiel, S.T. van, Wielopolski, P.A., Houston, G.C., Krestin, G.P. & Bernsen, M.R. (2010). Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells. Contrast Media & Molecular Imaging, 5(5), 247-257. Vukadinovic, D., Walsum, T. van, Manniesing, R., Rozie, S., Hameeteman, K., Weert, T.T. de, Lugt, A. van der & Niessen, W.J. (2010). Segmentation of the Outer Vessel Wall of the Common Carotid Artery in CTA. IEEE Transactions on Medical Imaging, 29(1), 65-76. 284

EMC NIHES-03-77-01 - Structuring of medical knowledge Programme in brief design Our first line of research deals with the formalization of medical knowledge, that is the description of knowledge according to a formal representation so that the knowledge can be made operational in a computer system. We do not limit ourselves to knowledge that is provided by experts or is described in journals or books, but also focus on the (semi)automatic extraction of knowledge from documented databases. With respect to documented databases, attention is paid to automated learning techniques for modeling medical knowledge, tailored to the specific problems in the medical domain. This includes research in the representation and use of uncertainty in medical knowledge, and learning by computers in interaction with human experts so that the specific strengths of both human and machine are utilized. It is of great importance to test the results of our research (both methodology and prototypes of systems) in the diverse application domains for their usability, in close collaboration with other investigators and clinical partners. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot medical informatics 0,48 4,86 0 0,02 5,36 Total 0,48 4,86 0 0,02 5,36 0 0 0 0 9 2 0 11 Artikel/Letter to the editor Hettne, K.M., Williams, AJ, Mulligen, E.M. van, Kleinjans, J, Tkachenko, V & Kors, J.A. (2010). Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining. Journal of Cheminformatics, 2(3). Hettne, K.M., Mulligen, E.M. van, Schuemie, M.J., Schijvenaars, R.J.A. & Kors, J.A. (2010). Rewriting and suppressing UMLS terms for improved biomedical term identification. Journal of Biomedical Semantics, 1(1). Kluttig, A., Schumann, B, Swenne, C.A., Kors, J.A., Kuss, O., Schmidt, H., Werdan, K., Haerting, J & Greiser, K.H. (2010). Association of health behaviour with heart rate variability: a population-based study. BMC Cardiovascular Disorders, 10. Leening, M.J.G., Elias-Smale, S.E., Felix, J.F., Kors, J.A., Deckers, J.W., Hofman, A., Stricker, B.H.C. & Witteman, J.C.M. (2010). Unrecognised myocardial infarction and long-term risk of heart failure in the elderly: the Rotterdam Study. Heart, 96(18), 1458-1462. Lipton, J.A., Nelwan, S.P., Domburg, R.T. van, Kors, J.A., El-Hendy, A.A.H.A., Schinkel, A.F.L. & Poldermans, D. (2010). Abnormal spatial QRS-T angle predicts mortality in patients undergoing dobutamine stress echocardiography for suspected coronary artery disease. Coronary Artery Disease, 21(1), 26-32. Lubitz, SA, Sinner, MF, Lunetta, KL, Makino, S, Pfeufer, A, Rahman, R, Veltman, C.E., Barnard, J, Bis, JC, Danik, SP, Sonni, A, Shea, MA, Monte, F del, Perz, S, Muller, M., Peters, A., Greenberg, SM, Furie, KL, Noord, C. van, Boerwinkle, E., Stricker, B.H.C., Witteman, J.C.M., Smith, JD, Chung, MK, Heckbert, SR, Benjamin, EJ, Rosand, J, Arking, DE, Alonso, A., Kaab, S & Ellinor, PT (2010). Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25. Circulation, 122(10), 976- U66. Postema, PG, Dessel, P.F.H.M. van, Kors, J.A., Linnenbank, A.C., Herpen, G. van, Ritsema van Eck, H.J., Geloven, N van, Bakker, J.M.T. de, Wilde, A.A.M. & Tan, H.L. (2010). Local Depolarization Abnormalities Are the Dominant Pathophysiologic Mechanism for Type 1 Electrocardiogram in Brugada Syndrome A Study of Electrocardiograms, Vectorcardiograms, and Body Surface Potential Maps During Ajmaline Provocation. Journal of the American College of Cardiology, 55(8), 789-797. Scheltens, T., Beus, MF de, Hoes, A.W., Rutten, F.H., Numans, M.E., Mosterd, A., Kors, J.A., Grobbee, D.E. & Bots, M.L. (2010). The potential yield of ECG screening of hypertensive patients: the Utrecht Health Project. Journal of Hypertension, 28(7), 1527-1533. Schreurs, CA, Algra, AM, Man, SC, Cannegieter, SC, Wall, E.E. van der, Schalij, M.J., Kors, J.A. & Swenne, C.A. (2010). The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram. Journal of Electrocardiology, 43(4), 294-301. Schuemie, M.J., Kang, N., Hekkelman, ML & Kors, J.A. (2010). GeneE: Gene and protein query expansion with disambiguation. Bioinformatics, 26(1), 147-148. Sotoodehnia, N, Isaacs, A.J., Bakker, PIW de, Dorr, M, Newton-Cheh, C, Nolte, I.M., Harst, P. van der, Muller, M., Eijgelsheim, M., Alonso, A., Hicks, AA, Padmanabhan, S, Hayward, C, Smith, AV, Polasek, O, Giovannone, S, Fu, JY, Magnani, JW, Marciante, KD, Pfeufer, A, Gharib, SA, Teumer, A, Li, M., Bis, JC, Rivadeneira, F., Aspelund, T, Kottgen, A, Johnson, T, Rice, K, Sie, M.P.S., Wang, YA, Klopp, N, Fuchsberger, C, Wild, SH, Leach, IM, Estrada, K, Volker, U, Wright, AF, Asselbergs, F.W., Qu, JX, Chakravarti, A, Sinner, MF, Kors, J.A., Petersmann, A, Harris, T.B., Soliman, EZ, Munroe, PB, Psaty, B.M., Oostra, B.A., Cupples, L.A., Perz, S, Boer, R.A. de, Uitterlinden, A.G., Volzke, H, Spector, T.D., Liu, FY, Boerwinkle, E., Dominiczak, AF, Rotter, JI, Herpen, G. van, Levy, D., Wichmann, HE, Gilst, W.H. van, Witteman, J.C.M., Kroemer, HK, Kao, WHL, Heckbert, SR, Meitinger, T, Hofman, A., Campbell, H, Folsom, A.R., Veldhuisen, D.J., Schwienbacher, C, O'Donnell, CJ, Volpato, CB, Caulfield, MJ, Connell, JM, Launer, L, Lu, XW, Franke, L, Fehrmann, RSN, Meerman, GT, Groen, H.J.M., Weersma, RK, Berg, L.H. van den, Wijmenga, C., Ophoff, R.A., Navis, G, Rudan, I, Snieder, H, Wilson, JF, Pramstaller, P.P., Siscovick, D.S., Wang, T.J., Gudnason, V, Duijn, C.M. van, Felix, SB, Fishman, GI & Jamshidi, Y (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), 1068-1076. 285

EMC NIHES-03-77-02 - Structuring of medical data Programme in brief design Medical data recorded in the context of clinical care should not only be available for patient care, but also be accessible for other purposes, such as scientific research, quality assurance, or management. The use of computers to record medical data is a necessary first step to allow data to be used for multiple purposes. Scientific research, however, has shown that the purpose of data collection is closely related to the nature and content of the data recorded. Different usage of the data creates different demands: data requirements in the context of a clinical trial are different than those in the context of management or quality assurance. In the research theme Structuring of Medical Data, the department of Medical Informatics studies methodologies that allow recording of data for multiple purposes. Our research is focused on generic models for medical data. The scientific challenge is to formulate generic models that are applicable to different specialties. The models, however, have to be usable in daily practice. An essential part of this research, therefore, is the validation of these models in daily care. Once electronic patient records are available, our research focus shifts to on the actual use of the data for multiple purposes. Together with clinicians, we study systems aimed at improving the quality of care. Together with other disciplines we also analyze observational databases and study issues involved in naturalistic trials. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot epidemiology 0 0,95 0 0,08 1,03 medical informatics 0,2 6,52 0 6,97 13,69 Total 0,2 7,47 0 7,05 14,72 2 0 0 2 46 2 0 50 Thesis Koopman, J.S.H.A. (2010, mei 19). The Epidemiology of Facial Pain. EUR (160 pag.). Prom./coprom.: Prof. Dr. M.C.J.M. Sturkenboom, Prof. Dr. F.J.P.M. Huygen & J.P. Dieleman. Risselada, R. (2010, november 10). Subarachnoid Haemorrhage. Epidemiological Studies on Aetiology and Outcome. EUR (128 pag.). Prom./coprom.: Prof. Dr. M.C.J.M. Sturkenboom & Prof. Dr. A. van der Lugt. Artikel/Letter to the editor Alberts, VP, Bos, M.J., Koudstaal, P.J., Hofman, A., Witteman, J.C.M., Stricker, B.H.C. & Breteler, M.M.B. (2010). Heart failure and the risk of stroke: the Rotterdam Study. European Journal of Epidemiology, 25(11), 807-812. Avillach, P., Joubert, M., Thiessard, F, Trifiro, G., Dufour, J-C, Pariente, A, Mougin, F, Polimeni, G, Catania, MA, Giaquinto, C., Mazzaglia, G, Fornari, C, Herings, R.M.C., Gini, R, Hippisley-Cox, J, Molokhia, M, Pedersen, LM, Fourrier-Reglat, A, Sturkenboom, M.C.J.M. & Fieschi, C. (2010). Design and evaluation of a semantic approach for the homogeneous identification of events in eight patient databases: a contribution to the European EU-ADR project. Studies in Health Technology and Informatics, 1085-1089. Baiardi, P, Ceci, A, Felisi, M, Cantarutti, L., Girotto, S, Sturkenboom, M.C.J.M. & Baraldi, E. (2010). In-label and off-label use of respiratory drugs in the Italian paediatric population. Acta Paediatrica, 99(4), 544-549. Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Pharmacoepidemiology and Drug Safety, 19(1), 75-81. Becker, M.L., Visser, L.E., Schaik, R.H.N. van, Hofman, A., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Pharmacogenetics Genomics, 20(1), 38-44. Blin, P, Blazejewski, S, Lignot, S, Lassalle, R, Bernard, MA, Jayles, D, Theophile, H, Benichou, J, Demeaux, JL, Ebbo, D, Franck, J, Moride, Y, Peyramond, D, Rouveix, B, Sturkenboom, M.C.J.M., Gehanno, P, Droz, C & Moore, N. (2010). Effectiveness of antibiotics for acute sinusitis in real-life medical practice. British Journal of Clinical Pharmacology, 70(3), 418-428. Durme, Y.M.T.A. van, Eijgelsheim, M., Joos, G.F., Hofman, A., Uitterlinden, A.G., Brusselle, GG & Stricker, B.H.C. (2010). Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. European Respiratory Journal, 36(1), 89-95. Eijgelsheim, M., Newton-Cheh, C, Sotoodehnia, N, Bakker, PIW de, Muller, M., Morrison, AC, Smith, AV, Isaacs, A.J., Sanna, S, Dorr, M, Navarro, P, Fuchsberger, C, Nolte, I.M., Geus, E.J.C. de, Estrada, K, Hwang, SJ, Bis, JC, Ruckert, IM, Alonso, A., Launer, L.J., Hottenga, J.J., Rivadeneira Ramirez, F., Noseworthy, PA, Rice, KM, Perz, S, Arking, DE, Spector, T.D., Kors, J.A., Aulchenko, Y.S., Tarasov, KV, Homuth, G., Wild, SH, Marroni, F, Gieger, C, Licht, CM, Prineas, RJ, Hofman, A., Rotter, JI, Hicks, AA, Ernst, F, Najjar, SS, Wright, AF, Peters, A., Fox, ER, Oostra, B.A., Kroemer, HK, Couper, D, Volzke, H, Campbell, H, Meitinger, T, Uda, M, Witteman, J.C.M., Psaty, B.M., Wichmann, HE, Harris, T.B., Kaab, S, Siscovick, D.S., Jamshidi, Y, Uitterlinden, A.G., Folsom, A.R., Larson, MG, Wilson, JF, Penninx, BW, Snieder, H, Pramstaller, P.P., Duijn, C.M. van, Lakatta, EG, Felix, SB, Gudnason, V, Pfeufer, A, Heckbert, SR, Stricker, B.H.C., Boerwinkle, E. & O'Donnell, CJ (2010). Genome-wide association analysis identifies multiple loci related to resting heart rate. Human Molecular Genetics, 19(19), 3885-3894. Ellinor, PT, Lunetta, KL, Glazer, NL, Pfeufer, A, Alonso, A., Chung, MK, Sinner, MF, Bakker, PIW de, Mueller, M, Lubitz, SA, Fox, E, Darbar, D, Smith, NL, Smith, JD, Schnabel, RB, Soliman, EZ, Rice, KM, Wagoner, DR Van, Beckmann, BM, Noord, C. van, Wang, K, Ehret, GB, Rotter, JI, Hazen, SL, Steinbeck, G, Smith, AV, Launer, L.J., Harris, T.B., Makino, S, Nelis, M, Milan, 286

DJ, Perz, S, Esko, T, Kottgen, A, Moebus, S, Newton-Cheh, C, Li, M., Moehlenkamp, S, Wang, T.J., Kao, WHL, Vasan, RS, Nothen, MM, MacRae, CA, Stricker, B.H.C., Hofman, A., Uitterlinden, A.G., Levy, D., Boerwinkle, E., Metspalu, A, Topol, E.J., Chakravarti, A, Gudnason, V, Psaty, B.M., Roden, DM, Meitinger, T, Wichmann, HE, Witteman, J.C.M., Barnard, J, Arking, DE, Benjamin, EJ, Heckbert, SR & Kaab, S (2010). Common variants in KCNN3 are associated with lone atrial fibrillation. Nature Genetics, 42(3), 240-U36. Ferrajolo, C., Capuano, A, Verhamme, K.M.C., Schuemie, M.J., Rossi, F, Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2010). Drug-induced hepatic injury in children: a case/non-case study of suspected adverse drug reactions in VigiBase. British Journal of Clinical Pharmacology, 70(5), 721-728. Flohil, S.C., Vries, E. de, Meurs, J.B.J. van, Fang, Y., Stricker, B.H.C., Uitterlinden, A.G. & Nijsten, T.E.C. (2010). Vitamin D- binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas. Experimental Dermatology, 19(12), 1103-1105. Groenen, M.J.M., Buuren, H.R. van, Henegouwen, GPV, Fockens, P., Lei, J. van der, Stuifbergen, WNHM, Schaar, PJ Van der, Kuipers, E.J. & Ouwendijk, RJT (2010). Validation study of automatically generated codes in colonoscopy using the endoscopic report system Endobase (R). Scandinavian Journal of Gastroenterology, 45(9), 1121-1126. Haak, P van den, Heintjes, E.M., Plat, AW, Meerding, W.J., Webb, K, Sturkenboom, M.C.J.M. & Herings, R.M.C. (2010). Determination of non-treatment with statins of high risk patients in the Netherlands. Current Medical Research & Opinion, 26(2), 271-278. Hancock, DB, Eijgelsheim, M., Wilk, JB, Gharib, SA, Loehr, LR, Marciante, KD, Franceschini, N, Durme, Y.M.T.A. van, Chen, TH, Barr, RG, Schabath, MB, Couper, DJ, Brusselle, GG, Psaty, B.M., Duijn, C.M. van, Rotter, JI, Uitterlinden, A.G., Hofman, A., Punjabi, NM, Rivadeneira Ramirez, F., Morrison, AC, Enright, P.L., North, KE, Heckbert, SR, Lumley, T, Stricker, B.H.C., O'Connor, GT & London, SJ (2010). Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature Genetics, 42(1), 45-U61. Hsia, Y, Neubert, A, Sturkenboom, M.C.J.M., Murray, ML, Verhamme, K.M.C., Sen, E., Giaquinto, C., Ceci, A & Wong, ICK (2010). Comparison of antiepileptic drug prescribing in children in three European countries. Epilepsia, 51(5), 789-796. Kardys, I., Deckers, J.W., Stricker, B.H.C., Vletter, W.B., Hofman, A. & Witteman, J.C.M. (2010). Distribution of echocardiographic parameters and their associations with cardiovascular risk factors in the Rotterdam Study. European Journal of Epidemiology, 25(7), 481-490. Kaur, G, Verhamme, K.M.C., Dieleman, J.P., Vanrolleghem, A., Soest, E.M. van, Stricker, B.H.C. & Sturkenboom, M.C.J.M. (2010). Association between calcium channel blockers and gingival hyperplasia. Journal of Clinical Periodontology, 37(7), 625-630. Kiiski, V, Vries, E. de, Flohil, S.C., Bijl, M.J., Hofman, A., Stricker, B.H.C. & Nijsten, T.E.C. (2010). Risk Factors for Single and Multiple Basal Cell Carcinomas. Archives of Dermatology, 146(8), 848-855. Koopman, J.S.H.A., Huygen, F.J.P.M., Dieleman, J.P., Mos, M. de & Sturkenboom, M.C.J.M. (2010). Pharmacological Treatment of Neuropathic Facial Pain in the Dutch General Population. Journal of Pain, 11(3), 264-272. Luijendijk, H.J., Tiemeier, H.W., Berg, J.F. van den, Bleumink, G.S., Hofman, A. & Stricker, B.H.C. (2010). Heart Failure and Incident Late-Life Depression. Journal of American Geriatrics Society, 58(8), 1441-1446. Morrison, AC, Felix, J.F., Cupples, L.A., Glazer, NL, Loehr, LR, Dehghan, A., Demissie, S, Bis, JC, Rosamond, WD, Aulchenko, Y.S., Wang, YA, Haritunians, T, Folsom, A.R., Rivadeneira, F., Benjamin, EJ, Lumley, T, Couper, D, Stricker, B.H.C., O'Donnell, CJ, Rice, KM, Chang, PP, Hofman, A., Levy, D., Rotter, JI, Fox, ER, Uitterlinden, A.G., Wang, T.J., Psaty, B.M., Willerson, J.T., Duijn, C.M. van, Boerwinkle, E., Witteman, J.C.M., Vasan, RS & Smith, NL (2010). Genomic Variation Associated With Mortality Among Adults of European and African Ancestry With Heart Failure The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Circulation-cardiovascular genetics, 3(3), 248-U64. Neubert, A, Verhamme, K.M.C., Murray, ML, Picelli, G, Hsia, Y, Sen, FE, Giaquinto, C., Ceci, A, Sturkenboom, M.C.J.M. & Wong, ICK (2010). The prescribing of analgesics and non-steroidal anti-inflammatory drugs in paediatric primary care in the UK, Italy and the Netherlands. Pharmacological Research, 62(3), 243-248. Newson, R.S., Witteman, J.C.M., Franco, OH, Stricker, B.H.C., Breteler, M.M.B., Hofman, A. & Tiemeier, H.W. (2010). Predicting survival and morbidity-free survival to very old age. Age, 32(4), 521-534. Noord, C. van, Dieleman, J.P., Herpen, G. van, Verhamme, K.M.C. & Sturkenboom, M.C.J.M. (2010). Domperidone and Ventricular Arrhythmia or Sudden Cardiac Death A Population-Based Case-Control Study in the Netherlands. Drug Safety, 33(11), 1003-1014. Noord, C. van, Eijgelsheim, M. & Stricker, B.H.C. (2010). Drug- and non-drug-associated QT interval prolongation. British Journal of Clinical Pharmacology, 70(1), 16-23. Noord, C. van, Sturkenboom, M.C.J.M., Straus, S.M.J.M., Hofman, A., Kors, J.A., Witteman, J.C.M. & Stricker, B.H.C. (2010). Serum glucose and insulin are associated with QTc and RR intervals in nondiabetic elderly. European Journal of Endocrinology, 162(2), 241-248. Noord, C. van, Dorr, M, Sturkenboom, M.C.J.M., Straus, S.M.J.M., Reffelmann, T, Felix, SB, Hofman, A., Kors, J.A., Haring, R, Jong, F.H. de, Nauck, M., Uitterlinden, A.G., Wallaschofski, H., Witteman, J.C.M., Volzke, H & Stricker, B.H.C. (2010). The association of serum testosterone levels and ventricular repolarization. European Journal of Epidemiology, 25(1), 21-28. 287

Peters, BJM, Rodin, AS, Klungel, O.H., Duijn, C.M. van, Stricker, B.H.C., Slot, R van 't, Boer, A. den & Zee, A.H. (2010). Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction. Pharmacogenomics, 11(8), 1065-1076. Peters, BJM, Rodin, AS, Klungel, O.H., Stricker, B.H.C., Boer, A. den & Zee, A.H. (2010). Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction. Pharmacogenetics Genomics, 20(12), 766-774. 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Risselada, R., Lingsma, H.F., Molyneux, AJ, Kerr, RSC, Yarnold, J, Sneade, M, Steyerberg, E.W. & Sturkenboom, M.C.J.M. (2010). Prediction of two month modified Rankin Scale with an ordinal prediction model in patients with aneurysmal subarachnoid haemorrhage. BMC Medical Research Methodology, 10. Risselada, R., Lingsma, H.F., Bauer-Mehren, A, Friedrich, CM, Molyneux, AJ, Kerr, RSC, Yarnold, J, Sneade, M, Steyerberg, E.W. & Sturkenboom, M.C.J.M. (2010). Prediction of 60 day case-fatality after aneurysmal subarachnoid haemorrhage: results from the International Subarachnoid Aneurysm Trial (ISAT). European Journal of Epidemiology, 25(4), 261-266. Rodenburg, E.M., Visser, L.E., Danser, A.H.J., Hofman, A., Noord, C. van, Witteman, J.C.M., Uitterlinden, A.G. & Stricker, B.H.C. (2010). Genetic variance in CYP2C8 and increased risk of myocardial infarction. Pharmacogenetics Genomics, 20(7), 426-434. 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Wyk, J.T. van, Mosseveld, B.M.T. & Lei, J. van der (2010). Is population-oriented IT supported preventive care in general practice feasible? A database study. Studies in Health Technology and Informatics, 160, 462-465. Yang, QO, Kottgen, A, Dehghan, A., Smith, AV, Glazer, NL, Chen, MH, Chasman, DI, Aspelund, T, Eiriksdottir, G, Harris, T.B., Launer, L, Nalls, M, Hernandez, D., Arking, DE, Boerwinkle, E., Grove, ML, Li, M., Kao, WHL, Chonchol, M, Haritunians, T, Li, G., Lumley, T, Psaty, B.M., Shlipak, M, Hwang, SJ, Larson, MG, O'Donnell, CJ, Upadhyay, A, Duijn, C.M. van, Hofman, A., Rivadeneira, F., Stricker, B.H.C., Uitterlinden, A.G., Pare, G, Parker, AN, Ridker, P.M., Siscovick, D.S., Gudnason, V, Witteman, J.C.M., Fox, CS & Coresh, J (2010). Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors. Circulation-cardiovascular genetics, 3(6), 523-530. Yasuno, K, Bilguvar, K, Bijlenga, P, Low, SK, Krischek, B, Auburger, G, Simon, M, Krex, D, Arlier, Z, Nayak, N, Ruigrok, YM, Niemelaa, M, Tajima, A, Fraunberg, MVZ, Doczi, T, Wirjatijasa, F, Hata, A, Blasco, J, Oszvald, A, Kasuya, H, Zilani, G, Schoch, B, Singh, P, Stuer, C, Risselada, R., Beck, J., Sola, T, Ricciardi, F, Aromaa, A, Illig, T, Schreiber, S., Duijn, C.M. van, Berg, L.H. van den, Perret, C, Proust, C, Roder, C.H., Ozturk, AK, Gaal, E, Berg, D. van den, Geisen, C, Friedrich, CM, Summers, P, Frangi, AF, State, MW, Wichmann, HE, Breteler, M.M.B., Wijmenga, C., Mane, S, Peltonen, L., Elio, V, Sturkenboom, M.C.J.M., Lawford, P, Byrne, J, Macho, J, Sandalcioglu, EI, Meyer, B, Raabe, A, Steinmetz, H, Rufenacht, D, Jaaskelainen, JE, Hernesniemi, J, Rinkel, G.J.E., Zembutsu, H, Inoue, I, Palotie, A, Cambien, F., Nakamura, Y, Lifton, RP & Gunel, M (2010). Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5), 420-U69. 289

EMC NIHES-04-55-01 - Assessment, aetiology and course of child and adolescent psychiatry Programme in brief design The main objective of this program is to study the frequency, determinants and course of child psychiatric disorders, such as anxiety, depression, somatoform disorders, aggressive and antisocial behaviours, hyperactivity, and developmental problems (autism, learning disorders, mental retardation). The program uses epidemiological methods to study psychopathology in general population, at risk, and clinical samples. These studies aim to develop assessment instruments and diagnostic procedures; assess the prevalence and incidence of child and adolescent disorders; study the onset and course of psychopathology from infancy to young adulthood using longitudinal and genetically sensitive research designs; assess the effectiveness of preventive and treatment approaches. General population studies The prevalence and course of child and adolescent psychiatric conditions has been studied in Dutch general population samples across the age range from 2 to 30 years. The influence of life events and personal and social-environmental determinants has been studied, and cross-cultural and secular trend analyses have been performed. These studies confirmed the high prevalence (7%) of serious psychiatric problems in Dutch children and adolescents as well as the cross-cultural similarity of child/adolescent psychopathology, and indicated that the use of mental health services at this age is mainly determined by severity of psychopathology, additional handicaps, and family burden. Longitudinal studies showed that earlier psychopathology is the strongest predictor of later psychopathology from childhood up to early adulthood, and is a strong predictor of later functional problems. Recently, the transgenerational transmission of psychopathology is being studies in a 24-year longitudinal design in which parental ratings of children s problem behaviour is compared with ratings on the same instrument obtained for the offspring 24 years later. Studies in general population samples also yielded improvements in the standardized assessment of psychopathology, ad well as contributions to the methodology of longitudinal studies (accelerated designs; developmental pathway analysis). The second generation of longitudinal studies in which determinants of the emergence and continuity of child psychopathology is being studied is well on its way. The focus is on two new large-scale longitudinal studies. The first, Generation R, is a multidisciplinary cohortstudy following 10.000 children from prebirth into young adulthood. The second,trails, is a cohortstudy of 2.500 10-year-olds in the northern provinces. The Rotterdam group focuses on anxiety disorders, illegal substance use, and conduct disorders. Both Generation R and Trails aim to unravel etiological mechanisms, with a special focus on biological determinants and gene-enviroment interactions and correlations. The first results of Generation R show the effects of smoking (both cannabis and cigarettes) on intrauterine growth and on early brain development. In Trails the associations between between autonomous nervous functioning and HPA axis functioning with both externalizing and internalizing problems have been studied. At risk and clinical populations We have assessed the prevalence and longitudinal course of problem behaviours and quality of life in ethnic minority groups, adopted children, children and adolescents with mental retardation, children with psychiatric conditions, and children with medical conditions (e.g. craniofacial abnormalities, congenitial cardiac conditions, meningococcal sepsis). Several studies on referred samples showed a very strong continuity of psychopathology up to 10 years after referral. Only few factors (learning problems, temperament, stress, family functioning) showed predictive power of later psychopathology over and above severity of earlier psychopathology. However, (chronic) physical problems appear to have considerable power in the prediction of later psychopathology (e.g. in mentally retarded children and adolescents). Studies on samples with chronic somatic disorders show the importance of cerebral involvement in child development, as well as the important role of psychological and personality factors in coping with these conditions. Intervention studies aiming anxiety disorders have started. Genetics In collaboration with the Free University Amsterdam, we have conducted (longitudinal) twin and adoption studies to determine genetic and environmental influences on problem behaviours in young children. Recent findings show changes in genetic influences on psychopathology from preschool- to school age, differential genetic and environmental influences on co-morbid psychopathological problems as well as genetic influences on the stability of problem behaviours. Considerable contributions have been made to the development of estimation methods in quantitative behavioural genetics (e.g. rater bias models). The behavioural genetic studies continue the study of large genetically sensitive samples (twins; adopted children) well into puberty using longitudinal designs and now include the detection of genetically sensitive syndromes of psychopathology (e.g. disruptive disorders). We are currently expanding this research by looking at the association between child psychiatric disorders (ADHD, anxiety disorders) and presynaptic gene networks. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot Generation R 0 0 0 0,8 0,8 pediatric psychiatry 8,26 7,52 0 9,93 25,71 Total 8,26 7,52 0 10,73 26,51 5 0 1 6 63 5 7 81 Thesis Creemers, H.E. (2010, maart 25). High Times. The role of temperament and other risk factors in the onset and continuation of cannabis use during adolescence. EUR (163 pag.). Prom./coprom.: Prof. Dr. F.C. Verhulst & Dr. A.C. Huizink. Henrichs, J. (2010, mei 19). Prenatal determinants of early behavioral and cognitive development. EUR (240 pag.). Prom./coprom.: Prof.Dr. H.G. Schmidt & Prof. Dr. F.C. Verhulst. Jansen, P.M. (2010, april 01). Self-report in Youth Health Monitoring: evidence from the Rotterdam Youth Monitor. EUR (159 pag.). Prom./coprom.: Prof.Dr. M.C.H. Donker, Prof. Dr. F.C. Verhulst & EJ de Wilde. Marroun El, H. (2010, maart 04). Prenatal Cannabis Exposure & Infant Development. EUR (201 pag.). Prom./coprom.: Prof. Dr. F.C. Verhulst, W van den Brink & Dr. A.C. Huizink. Reef, J. (2010, mei 21). Adult consequences of Child psychopathology. EUR (177 pag.). Prom./coprom.: Prof. Dr. F.C. Verhulst. 290

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Henrichs, J., Schokking, J.J., Schenk, JJ, Ghassabian, A., Schmidt, H.G., Visser, T.J., Hooijkaas, H., Muinck Keizer-Schrama, S.M.P.F., Hofman, A., Jaddoe, V.W.V.K., Visser, W., Steegers, E.A.P., Verhulst, F.C., Rijke, Y.B. de & Tiemeier, H.W. (2010). Maternal Thyroid Function during Early Pregnancy and Cognitive Functioning in Early Childhood: The Generation R Study. Journal of Clinical Endocrinology and Metabolism, 95(9), 4227-4234. Herba, C.M., Roza, S.J., Govaert, P., Rossum, J van, Hofman, A., Jaddoe, V.W.V.K., Verhulst, F.C. & Tiemeier, H.W. (2010). Infant Brain Development and Vulnerability to Later Internalizing Difficulties: The Generation R Study. Journal of the American Academy Child Adolescent Psychiatry, 49(10), 1053-1063. Hoopen, L.W. ten & Nijs, P.F.A. de (2010). Congres Review: Tiende Nationaal Autisme Congres. Wetenschappelijk Tijdschrift Autisme, 1, 35-37. Hoopen, L.W. ten & Nijs, P.F.A. de (2010). De genetische zaken van autisme: een overzicht. 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Ivanova, MY, Achenbach, T.M., Rescorla, LA, Harder, VS, Ang, RP, Bilenberg, N, Bjarnadottir, G, Capron, C, Pauw, SSW De, Dias, P, Dobrean, A, Doepfner, M, Duyme, M, Eapen, V, Erol, N., Esmaeili, EM, Ezpeleta, L, Frigerio, A, Goncalves, MM, Gudmundsson, HS, Jeng, SF, Jetishi, P, Jusiene, R, Kim, YA, Kristensen, S., Lecannelier, F, Leung, P.W.L., Liu, JH, Montirosso, R, Oh, KJ, Plueck, J, Pomalima, R, Shahini, M, Silva, JR, Simsek, Z., Sourander, A, Valverde, J, Leeuwen, KG Van, Woo, BSC, Wu, YT, Zubrick, S.R. & Verhulst, F.C. (2010). Preschool Psychopathology Reported by Parents in 23 Societies: Testing the Seven-Syndrome Model of the Child Behavior Checklist for Ages 1.5-5. Journal of the American Academy Child Adolescent Psychiatry, 49(12), 1215-1224. Jaddoe, V.W.V.K., Duijn, C.M. van, Heijden, A.J. van der, Mackenbach, J.P., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Uitterlinden, A.G., Verhulst, F.C. & Hofman, A. (2010). The Generation R Study: design and cohort update 2010. European Journal of Epidemiology, 25(11), 823-841. Jansen, P.W., Tiemeier, H.W., Verhulst, F.C., Burdorf, A., Jaddoe, V.W.V.K., Hofman, A., Moll, H.A., Verburg, B.O., Steegers, E.A.P., Mackenbach, J.P. & Raat, H. (2010). Employment status and the risk of pregnancy complications: the Generation R Study. Occupational and Environmental Medicine, 67, 387-394. Jansen, P.W., Raat, H., Mackenbach, J.P., Jaddoe, V.W.V.K., Hofman, A., Oort, F.V.A. van, Verhulst, F.C. & Tiemeier, H.W. (2010). National Origin and Behavioural Problems of Toddlers: The Role of Family Risk Factors and Maternal Immigration Characteristics. Journal of Abnormal Child Psychology, 38(8), 1151-1164. Janssens, KAM, Rosmalen, J..G.M., Ormel, J., Oort, F.V.A. van & Oldehinkel, A.J. (2010). Anxiety and depression are risk factors rather than consequences of functional somatic symptoms in a general population of adolescents: The TRAILS study. Journal of Child Psychology and Psychiatry, 51(3), 304-312. Jaspers, M, Winter, A.F. de, Meer, G de, Stewart, RE, Verhulst, F.C., Ormel, J. & Reijneveld, S.A. (2010). Early Findings of Preventive Child Healthcare Professionals Predict Psychosocial Problems in Preadolescence: The TRAILS Study. Journal of Pediatrics, 157(2), 316-U179. Jaspers, M, Meer, G de, Verhulst, F.C., Ormel, J. & Reijneveld, S.A. (2010). Limited validity of parental recall on pregnancy, birth, and early childhood at child age 10 years. Journal of Clinical Epidemiology, 63(2), 185-191. Korhonen, T, Leeuwen, AP van, Reijneveld, S.A., Ormel, J., Verhulst, F.C. & Huizink, A.C. (2010). Externalizing Behavior Problems and Cigarette Smoking as Predictors of Cannabis Use: The TRAILS Study. Journal of the American Academy Child Adolescent Psychiatry, 49(1), 61-69. 292

Laan, A. van der, Veenstra, R., Bogaerts, S, Verhulst, F.C. & Ormel, J. (2010). Serious, Minor, and Non-Delinquents in Early Adolescence: The Impact of Cumulative Risk and Promotive Factors. The TRAILS Study. Journal of Abnormal Child Psychology, 38(3), 339-351. Legerstee, J.S., Tulen, J.H.M., Dierckx, B., Treffers, PDA, Verhulst, F.C. & Utens, E.M.W.J. (2010). CBT for childhood anxiety disorders: differential changes in selective attention between treatment responders and non-responders. Journal of Child Psychology and Psychiatry, 51(2), 162-172. Legerstee, J.S., Garnefski, N, Jellesma, FC, Verhulst, F.C. & Utens, E.M.W.J. (2010). Cognitive coping and childhood anxiety disorders. European Child & Adolescent Psychiatry, 19(2), 143-150. Liber, JM, McLeod, BD, Widenfelt, BM Van, Goedhart, AW, Utens, E.M.W.J., Leeden, A van der & Treffers, PDA (2010). Examining the Relation Between the Therapeutic Alliance, Treatment Adherence, and Outcome of Cognitive Behavioral Therapy for Children With Anxiety Disorders. Behavior Therapy, 41(2), 172-186. Liber, JM, Widenfelt, BM Van, Leeden, A van der, Goedhart, AW, Utens, E.M.W.J. & Treffers, PDA (2010). The Relation of Severity and Comorbidity to Treatment Outcome with Cognitive Behavioral Therapy for Childhood Anxiety Disorders. Journal of Abnormal Child Psychology, 38(5), 683-694. Luijk, P.C.M., Saridjan, N.S., Tharner, A., Ijzendoorn, MH van, Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2010). Attachment, Depression, and Cortisol: Deviant Patterns in Insecure-Resistant and Disorganized Infants. Developmental Psychobiology, 52(5), 441-452. Luijk, P.C.M., Velders, F.P., Tharner, A., IJzerdoorn, MH, Bakermans-Kranenburg, MJ, Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2010). FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction. Psychoneuroendocrinology, 35(10), 1454-1461. Marroun El, H., Tiemeier, H.W., Steegers, E.A.P., Roos-Hesselink, J.W., Jaddoe, V.W.V.K., Hofman, A., Verhulst, F.C., Brink, W van den & Huizink, A.C. (2010). A prospective study on intrauterine cannabis exposure and fetal blood flow. Early Human Development, 86(4), 231-236. Newson, R.S., Hek, K., Luijendijk, H.J., Hofman, A., Witteman, J.C.M. & Tiemeier, H.W. (2010). Atherosclerosis and Incident Depression in Late Life. Archives of General Psychiatry, 67(11), 1144-1151. Nijmeijer, JS, Hartman, C.A., Rommelse, NNJ, Altink, ME, Buschgens, CJM, Fliers, EA, Franke, B., Minderaa, R.B., Ormel, J., Sergeant, J.A., Verhulst, F.C., Buitelaar, J.K. & Hoekstra, PJ (2010). Perinatal risk factors interacting with catechol O- methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD. Journal of Child Psychology and Psychiatry, 51(11), 1242-1250. Oort, F.V.A. van, Verhulst, F.C., Ormel, J. & Huizink, A.C. (2010). Prospective community study of family stress and anxiety in (pre)adolescents: the TRAILS study. European Child & Adolescent Psychiatry, 19(6), 483-491. Polderman, J.C., Boomsma, D.I., Bartels, M.C., Verhulst, F.C. & Huizink, A.C. (2010). A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatrica Scandinavica, 122(4), 271-284. Polderman, J.C., Bartels, M.C., Verhulst, F.C., Huizink, A.C., Beijsterveldt, C.E.M. van & Boomsma, D.I. (2010). No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study. Journal of Epidemiology & Community Health, 64, 36-40. Reef, J., Meurs, I. van, Verhulst, F.C. & Ende, J. van der (2010). Children's Problems Predict Adults' DSM-IV Disorders Across 24 Years. Journal of the American Academy Child Adolescent Psychiatry, 49(11), 1117-1124. Reef, J., Diamantopoulou, S., Meurs, I. van, Verhulst, F.C. & Ende, J. van der (2010). Predicting adult emotional and behavioral problems from externalizing problem trajectories in a 24-year longitudinal study. European Child & Adolescent Psychiatry, 19(7), 577-585. Reijneveld, S.A., Veenstra, R., Winter, A.F. de, Verhulst, F.C., Ormel, J. & Meer, G de (2010). Area Deprivation Affects Behavioral Problems of Young Adolescents in Mixed Urban and Rural Areas: The TRAILS Study. Journal of Adolescent Health, 46(2), 189-196. Robbers, S.C.C., Bartels, M.C., Oort, F.V.A. van, Beijsterveldt, C.E.M. van, Ende, J. van der, Verhulst, F.C., Boomsma, D.I. & Huizink, A.C. (2010). A Twin-Singleton Comparison of Developmental Trajectories of Externalizing and Internalizing Problems in 6-to 12-Year-Old Children. Twin Research and Human Genetics, 13(1), 79-87. Robschlager, K. & Phaff, J. (2010). Samen spelen. Een werkmodel voor ervaringsgerichte groepstherapie bij kinderen. Tijdschrift voor vaktherapie, 1, 25-35. Roza, S.J., Batenburg-Eddes, T. van, Steegers, E.A.P., Jaddoe, V.W.V.K., Mackenbach, J.P., Hofman, A., Verhulst, F.C. & Tiemeier, H.W. (2010). Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study. British Journal of Nutrition, 103(3), 445-452. Saridjan, N.S., Huizink, A.C., Koetsier, J.A., Jaddoe, V.W.V.K., Mackenbach, J.P., Hofman, A., Kirschbaum, C, Verhulst, F.C. & Tiemeier, H.W. (2010). Do social disadvantage and early family adversity affect the diurnal cortisol rhythm in infants? The Generation R Study. Hormones & Behavior, 57(2), 247-254. 293

Sijtsema, JJ, Veenstra, R., Lindenberg, S, Roon, A.M. van, Verhulst, F.C., Ormel, J. & Riese, H (2010). Mediation of Sensation Seeking and Behavioral Inhibition on the Relationship Between Heart Rate and Antisocial Behavior: The TRAILS Study. Journal of the American Academy Child Adolescent Psychiatry, 49(5), 493-502. Silva, L.M., Jansen, P.W., Steegers, E.A.P., Jaddoe, V.W.V.K., Arends, L.R., Tiemeier, H.W., Verhulst, F.C., Moll, H.A., Hofman, A., Mackenbach, J.P. & Raat, H. (2010). Mother's educational level and fetal growth: the genesis of health inequalities. International Journal of Epidemiology, 39, 1250-1261. Spijkerboer, A.W., Koning, W.B. de, Duivenvoorden, H.J., Bogers, A.J.J.C., Verhulst, F.C., Helbing, W.A. & Utens, E.M.W.J. (2010). Medical predictors for long-term behavioral and emotional outcomes in children and adolescents after invasive treatment of congenital heart disease. Journal of Pediatric Surgery, 45, 2146-2153. Tiemeier, H.W., Lenroot, RK, Greenstein, DK, Tran, LL, Pierson, R & Giedd, JN (2010). Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage, 49, 63-70. Toorn, S.L.M. van der, Huizink, A.C., Utens, E.M.W.J., Verhulst, F.C., Ormel, J. & Ferdinand, R.F. (2010). Maternal depressive symptoms, and not anxiety symptoms, are associated with positive mother-child reporting discrepancies of internalizing problems in children: a report on the TRAILS Study. European Child & Adolescent Psychiatry, 19(4), 379-388. Utens, E.M.W.J. (2010). Een aangeboren hartafwijking en seksualiteit. Sinus, 9, 38-39. Utens, E.M.W.J. (2010). Hoe ga je als ouders om met het feit dat je kind een aangeboren hartafwijking heeft? Sinus, 9, 18-21. Veen, V, Stevens, G, Doreleijers, T, Ende, J. van der & Vollebergh, W. (2010). Ethnic differences in mental health among incarcerated youths: do Moroccan immigrant boys show less psychopathology than native Dutch boys? European Child & Adolescent Psychiatry, 19(5), 431-440. Vegt, E.J.M. van der, Ende, J. van der, Huizink, A.C., Verhulst, F.C. & Tiemeier, H.W. (2010). Childhood Adversity Modifies the Relationship Between Anxiety Disorders and Cortisol Secretion. Biological Psychiatry, 68(11), 1048-1054. Verhulst, F.C. (2010). Autism spectrum disorders: the word is not a disease. Nederlands Tijdschrift voor Geneeskunde, 154, 1748. Vermunt, L.C.A.C., Buysse, C.M.P., Joosten, K.F.M., Hazelzet, J.A., Verhulst, F.C. & Utens, E.M.W.J. (2010). Recovery in parents of children and adolescents who survived septic shock caused by Neisseria meningitidis: a cross-sectional study. Intensive and Critical Care Nursing, 26, 128-137. Visser, A.M., Jaddoe, V.W.V.K., Hofman, A., Moll, H.A., Steegers, E.A.P., Tiemeier, H.W., Raat, H., Breteler, M.M.B. & Arts, W.F.M. (2010). Fetal Growth Retardation and Risk of Febrile Seizures. Pediatrics, 126(4), E919-E925. Visser, A.M., Jaddoe, V.W.V.K., Arends, L.R., Tiemeier, H.W., Hofman, A., Moll, H.A., Steegers, E.A.P., Breteler, M.M.B. & Arts, W.F.M. (2010). Paroxysmal disorders in infancy and their risk factors in a population-based cohort: the Generation R Study. Developmental Medicine & Child Neurology, 52(11), 1014-1020. White, T.J.H., Su, S, Schmidt, M.N., Kao, CY & Sapiro, G. (2010). The development of gyrification in childhood and adolescence. Brain & Cognition, 72(1), 36-45. Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Passchier, J. & Tiemeier, H.W. (2010). Determinants of Somatic Complaints in 18-month-old Children: The Generation R Study. Journal of Pediatric Psychology, 35(3), 306-316. Part of book - abstract Rijen, E.H.M. van & Utens, E.M.W.J. (2010). Psychological Aspects of Congenital Heart Disease. In DF Wyszynski, A Correa- Villasenor & TP Graham (Eds.), Children in Congenital Heart Defects, from origin to treatment (pp. 338-356). Oxford: Oxford university press. Valenkamp, M.W., Verheij, F., Ende, J. van der, Verhulst, F.C. & Nijman, H. (2010). Development and evaluation of the Individual Proactive Aggression management method for residential child psychiatry and child care. In EJ Knorth, ME Kalverboer & J Knot-Dickscheit (Eds.), Insite Out. How interventions in child and family care work an international source book (pp. 379-381). Antwerpen/apeldoorn: Garant. Wielemaker, J.F. & Verheij, F. (2010). Follow-up of long-term child psychiatric residential care. In EJ Knorth, ME Kalverboer & J Knot-Dickscheit (Eds.), Insite Out. How interventions in child and family care work an international source book (pp. 373-376). Antwerpen/Apeldoorn: Garnat. Boekredactie Verheij, F. & Oele, C. (Eds.). (2010). Klassiekers van de kinder- en jeugdpscyhotherapie; Werken met kind en gezin. Assen: Van Gorcum. 294

EMC NIHES-04-56-01 - Adaptation of (future) patients to disease and treatment in order to improve counselling and guidance Programme in brief design his programme investigates the emotional response to disease and treatment, and the ways to influence these emotions positively. The principal medical topics addressed are: `pain, `quality of life,, `clinical genetics, `psychotherapy and `reproductive medicine,. The programme is part of NIHES and carried out with many clinical departments of the Erasmus MC. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot medical psychology & psychotherapy 3,31 1,9 0,93 1,32 7,46 Total 3,31 1,9 0,93 1,32 7,46 3 0 0 3 29 1 6 39 Thesis Bruijn, J.J. de (2010, september 29). Quality of life and psychological functioning in observational and intervention studies in childhood migraine. EUR. Prom./coprom.: Prof. Dr. W.F.M. Arts & Prof.Dr. J. Passchier. Niet, J.E. de (2010, december 14). New approaches in obesity treatment. EUR (125 pag.). Prom./coprom.: Prof.Dr. J. Passchier & Prof. Dr. J.S.E. Laven. Soeteman, D.I. (2010, juni 03). Economic evaluation of psychotherapy for personality disorders. EUR (129 pag.). Prom./coprom.: Prof.dr. J.J. van Busschbach. Artikel/Letter to the editor Baars, J.E., Siegel, CA, Spijker, A. van t, Markus, T, Kuipers, E.J. & Woude, C.J. van der (2010). Inflammatory bowel diseasepatients are insufficiently educated about the basic characteristics of their disease and the associated risk of colorectal cancer. Digestive and Liver Disease, 42(11), 777-784. Bakker, T.J.E.M., Duivenvoorden, H.J., Lee, J. van der, Krulder, J.W.M., Driesen, J.J.M. & Ribbe, M.W. (2010). Prevalence and prognostic importance of riskfactors for long hospital stay within elderly patients admitted to a hsopital; a clinical-impirical study. Tijdschrift voor Gerontologie en Geriatrie, 41, 177-186. Bartak, A, Spreeuwenberg, MD, Andrea, H., Holleman, L., Rijnierse, P, Rossum, BV, Hamers, E.F.M., Meerman, AMMA, Aerts, J, Busschbach, J.J. van, Verheul, R., Stijnen, T. & Emmelkamp, P.M.G. (2010). Effectiveness of different modalities of psychotherapeutic treatment for patients with cluster C personality disorders: results of a large prospective multicentre study. Psychotherapy and Psychosomatics, 79, 20-30. Bauer, S, Niet, J.E. de, Timman, R. & Kordy, H (2010). Enhancement of care through self-monitoring and tailored feedback via text messaging and their use in the treatment of childhood overweight. Patient Education and Counseling, 79(3), 315-319. Bruijn, J.A., Locher, H., Passchier, J., Dijkstra, N. & Arts, W.F.M. (2010). Psychopathology in Children and Adolescents With Migraine in Clinical Studies: A Systematic Review. Pediatrics, 126(2), 323-332. Damen, T.H.C., Timman, R., Kunst, EH, Gopie, JP, Bresser, P.J.C., Seynaeve, C., Menke - Pluijmers, M.B.E., Mureau, M.A.M., Hofer, S.O.P. & Tibben, A. (2010). High satisfaction rates in women after DIEP flap breast reconstruction. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(1), 93-100. Elderen, T Van, Mutlu, D, Karstanje, J., Passchier, J., Tibben, A. & Duivenvoorden, H.J. (2010). Turkish Female Immigrants' Intentions to Participate in Preconception Carrier Screening for Hemoglobinopathies in the Netherlands: An Empirical Study. Public Health Genomics, 13(7-8), 415-423. Gerhards, S.A.H., Graaf, L.E. de, Jacobs, L.E. de, Severens, J.L., Huibers, M.J.H., Arntz, A., Riper, H., Widdershoven, G., Metsemakers, J.F.M. & Evers, S.M.A.A. (2010). Economic evaluation of online computerised cognitive-behavioural therapy without support for depression in primary care: randomised trial. British Journal of Psychiatry, 196, 310-318. Golicki, D, Jakubczyk, M, Niewada, M, Wrona, W & Busschbach, J.J. van (2010). Valuation of EQ-5D Health States in Poland: First TTO-Based Social Value Set in Central and Eastern Europe. Value in Health, 13(2), 289-297. Graaf, L.E. de, Huibers, MJH, Cuijpers, P. & Arntz, A. (2010). Minor and major depression in the general population: does dysfunctional thinking play a role? Comprehensive Psychiatry, 51(3), 266-274. Graaf, L.E. de, Hollon, SD & Huibers, MJH (2010). Predicting Outcome in Computerized Cognitive Behavioral Therapy for Depression in Primary Care: A Randomized Trial. Journal of Consulting and Clinical Psychology, 78(2), 184-189. Graaf, L.E. de, Gerhards, S.A.H., Arntz, A., Riper, H., Metsemakers, J.F.M., Evers, S.M.A.A., Severens, H, Widdershoven, G.A.M. & Huibers, M. (2010). Effectiviteit van online cognitieve gedragstherapie voor depressie in deeerste lijn. Gedragstherapie, 43, 59-77. Gutteling, J.J., Duivenvoorden, H.J., Busschbach, J.J. van, Man, R.A. de & Darlington - Molkenboer, A.S. (2010). Psychological Determinants of Health-Related Quality of Life in Patients With Chronic Liver Disease. Psychosomatics, 51(2), 157-165. 295

Ingenhoven, T, Lafay, P, Rinne, T, Passchier, J. & Duivenvoorden, H.J. (2010). Effectiveness of Pharmacotherapy for Severe Personality Disorders: Meta-Analyses of Randomized Controlled Trials. Journal of Clinical Psychiatry, 71(1), 14-25. Latour, J.M., Hazelzet, J.A., Duivenvoorden, H.J. & Goudoever, J.B. van (2010). Perceptions of parents, nurses and physicians on neonatal intensiver care practices. Journal of Pediatrics, 157(2), 215-220. Massey, E., Kranenburg, L.W., Zuidema, W.C., Hak, G., Erdman, R.A.M., Hilhorst, M.T., Ijzermans, J.N.M., Busschbach, J.J. van & Weimar, W. (2010). Encouraging Psychological Outcomes After Altruistic Donation to a Stranger. American Journal of Transplantation, 10(6), 1445-1452. Mazer, P., Gischler, S., Cammen - van Zijp, M.H.M., Tibboel, D., Bax, N.M.A., Meijers-IJsselstijn, H., Dijk, M. van & Duivenvoorden, H.J. (2010). Early developmental assessment of children with major non-cardiac congenital anomalies predicts development at the age of 5 years. Developmental Medicine & Child Neurology, 52, 1154-1159. Merelle, S.Y.M., Sorbi, M.J., Duivenvoorden, H.J. & Passchier, J. (2010). Qualities and Health of Lay Trainers With Migraine for Behavioral Attack Prevention. Headache, 50(4), 613-625. Meulen, I van der, Sandt-Koenderman, W.M.E., Duivenvoorden, H.J. & Ribbers, G.M. (2010). Measuring verbal and non-verbal communication in aphasia: reliability, validity, and sensitivity to change of the Scenario Test. International Journal of Language & Communication Disorders, 45(4), 424-435. Niet, J.E. de, Koning, C.M. de, Pastoor, H., Duivenvoorden, H.J., Valkenburg, O., Ramakers, M.J., Passchier, J., Klerk, C. de & Laven, J.S.E. (2010). Psychological well-being and sexarche in women with polycystic ovary syndrome. Human Reproduction, 25(6), 1497-1503. Roodnat, J.I., Zuidema, W., Wetering, J. van de, Klerk, M. de, Erdman, R.A.M., Massey, E., Hilhorst, M.T., Ijzermans, J.N.M. & Weimar, W. (2010). Altruistic Donor Triggered Domino-Paired Kidney Donation for Unsuccessful Couples from the Kidney- Exchange Program. American Journal of Transplantation, 10(4), 821-827. Soeteman, D.I., Verheul, R., Delimon, J, Meerman, AMMA, Eijnden, E van den, Rossum, BV, Ziegler, U, Thunnissen, M, Busschbach, J.J. van & Kim, JJ (2010). Cost-effectiveness of psychotherapy for cluster B personality disorders. British Journal of Psychiatry, 196(5), 396-403. Spijkerboer, A.W., Koning, W.B. de, Duivenvoorden, H.J., Bogers, A.J.J.C., Verhulst, F.C., Helbing, W.A. & Utens, E.M.W.J. (2010). Medical predictors for long-term behavioral and emotional outcomes in children and adolescents after invasive treatment of congenital heart disease. Journal of Pediatric Surgery, 45, 2146-2153. Spreeuwenberg, MD, Bartak, A, Croon, M.A., Hagenaars, JA, Busschbach, J.J. van, Andrea, H., Twisk, J & Stijnen, T. (2010). The Multiple Propensity Score as Control for Bias in the Comparison of More Than Two Treatment Arms An Introduction From a Case Study in Mental Health. Medical Care, 48(2), 166-174. Timman, R., Tibben, A. & Wintzen, A.R. (2010). MYOTONIC DYSTROPHY THE BURDEN FOR PATIENTS AND THEIR PARTNERS. Journal of Rehabilitation Medicine, 42(9), 823-830. Verhagen, A.P., Damen, L., Berger, M.Y., Lenssinck, M.B., Passchier, J. & Koes, B.W. (2010). Behandeling van spanningshoofdpijn: paracetamol en NSAID s werken. Nederlands Tijdschrift voor Geneeskunde, 154, 1924. Verhagen, A.P., Damen, L., Berger, M.Y., Passchier, J. & Koes, B.W. (2010). Lack of benefit for prophylactic drugs of tensiontype headache in adults: a systematic review. Family Practice, 27(2), 151-165. Vermeulen, J., Gosselink, M.P., Busschbach, J.J. van & Lange, J.F. (2010). Avoiding or Reversing Hartmann's Procedure Provides Improved Quality of Life After Perforated Diverticulitis. Journal of Gastrointestinal Surgery, 14(4), 651-657. Versnel, S.L., Duivenvoorden, H.J., Passchier, J. & Mathijssen, I.M.J. (2010). Satisfaction with facial appearance and its determinants in adults with severe congenital facial disfigurement: A case-referent study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 63(10), 1642-1649. Visser, N.J., Damen, T.H.C., Timman, R., Hofer, S.O.P. & Mureau, M.A.M. (2010). Surgical Results, Aesthetic Outcome, and Patient Satisfaction after Microsurgical Autologous Breast Reconstruction following Failed Implant Reconstruction. Plastic and Reconstructive Surgery, 126(1), 26-36. Wolff, N.J., Darlington, A.S., Hunfeld, J.A.M., Verhulst, F.C., Jaddoe, V.W.V.K., Hofman, A., Passchier, J. & Tiemeier, H.W. (2010). Determinants of Somatic Complaints in 18-month-old Children: The Generation R Study. Journal of Pediatric Psychology, 35(3), 306-316. Zonneveld, L.N.L., Duivenvoorden, H.J., Passchier, J. & Spijker, A. van t (2010). Tailoring a Cognitive Behavioural Model for Unexplained Physical Symptoms to Patient's Perspective: A Bottom-Up Approach. Clinical Psychology & Psychotherapy, 17(6), 528-535. Part of book - abstract Busschbach, J.J. van & Bleichrodt, H. (2010). Waarderend kwaliteit-van-levenonderzoek. In Van kosten tot effecten: een handleiding voor evaluatiesstudies in de gezondheidszorg (pp. 77-91). Soeteman, D.I. & Busschbach, J.J. van (2010). Kosten/baten en kosteneffectiviteit van preventie en behandeling. In Misdadigers van Morgen (pp. 176-189). 296

Rapport Bonke, B. & Luijk, S.J. (2010). Protocol ludidium Abeundi. : NFU. Busschbach, J.J. van & Delwel, GO (2010). Het pakketprincipe kosteneffectiviteit achtergrondstudie ten behoeve van de appraisal fase in pakketbeheer. : Uitgave College voor zorgverzekeringen. 297

EMC NIHES-05-63-01 - Health care management (theme 3) Programme in brief design This research line focuses on the social, legal and organisational aspects of management of professional knowledge, quality systems, information and communication technology in health care and health care management. The programme aims to translate theories of organisation, management and policy into practical guidelines and recommendations for health care organisations. Case studies are undertaken to gain insight in the dynamics of inter- and intra-organisational networks and in opportunities for network management. Special emphasis is put on the quality and accessibility of health care for ethnic minorities. Finally the programme evaluates effects of new health care legislation. Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot HPM-Bedrijfsvoering voor zorgorganisaties 5,51 10,48 0 9,46 25,45 HPM-Health Care Governance 0,98 0,6 0 1,94 3,52 Total 6,49 11,08 0 11,4 28,97 2 0 0 2 29 13 27 71 Thesis Cramm, J.M. (2010, december 14). Health and social burdens of people living in an economically and health-deprived area. EUR (167 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof.Dr. J.J. van de Klundert & Dr. A.P. Nieboer. Stepaniak, P.S. (2010, december 16). Modeling and management of variation in the operating theatre. EUR (157 pag.) (Ridderkerk: Simone Vinke, Ridderprint BV). Prom./coprom.: Dr.Ir. G. de Vries & Prof.Dr. J.J. van de Klundert. Artikel/Letter to the editor Aarts, J.E.C.M., Callen, J., Coiera, E. & Westbrook, J. (2010). Information Technology in Health Care: Socio-technical approaches. International Journal of Medical Informatics, 79, 389-390. Adams, S.A. (2010). Blog-based applications and health information: Two case studies that illustrate important questions for Consumer Health Informatics (CHI) research. International Journal of Medical Informatics, 79, e89-e96. Adams, S.A. (2010). Revisiting the online health information reliability debate in the wake of "web 2.0": An inter-disciplinary literature and website review. International Journal of Medical Informatics, 79, 391-400. Beuscart-Zephir, M.C., Aarts, J.E.C.M. & Elkin, P. (2010). Human factors engineering for healthcare IT clinical applications. International Journal of Medical Informatics, 79(4), 223-224. Broer, T., Nieboer, A.P. & Bal, R.A. (2010). Opening the black box of quality improvement collaboratives: an Actor-Network theory approach. Bmc Health Services Research, 10(265), 1-9. Broer, T., Nieboer, A.P. & Bal, R.A. (2010). Quest for client autonomy in improving long-term mental health care. International Journal of Mental Health Nursing, 19(6), 385-393. Buljac, M., Dekker - van Doorn, C.M., Wijngaarden, J.D.H. van & Wijk, K.P. van (2010). Interventions to improve team effectiveness: A systematic review. Health Policy, 94(3), 183-195. Cramm, J.M., Moller, V. & Nieboer, A.P. (2010). Improving Subjective Well-being of the Poor in the Eastern Cape. Journal of Health Psychology, 15(7), 1012-1019. Cramm, J.M., Exel, N.J.A. van, Moller, V. & Finkenflugel, H.J.M. (2010). Patient Views on Determinants of Compliance with Tuberculosis Treatment in the Eastern Cape, South Africa: An Application of Q-Methodology. The patient: Patient-Centered Outcomes Research, 3(3), 159-172. Cramm, J.M., Finkenflugel, H.J.M., Moller, V. & Nieboer, A.P. (2010). TB treatment initiation and adherence in a South African community influenced more by perceptions than by knowledge of tuberculosis. BMC Public Health, 10(72), 1-8. Evers, J. & Staa, A.L. van (2010). Niet eenvoudiger, wel creatiever en efficienter. KWALON. Tijdschrift voor Kwalitatief Onderzoek in Nederland, 15(1), 17-19. Evers, J. & Staa, A.L. van (2010). 'Thick analysis": strategie om de kwaliteit van kwalitatieve data-analyse te verhogen. KWALON. Tijdschrift voor Kwalitatief Onderzoek in Nederland, 15(1), 5-12. Glass, C.A. & Oostrum, J.M. van (2010). Bun splitting: a practical cutting stock problem. Annals of Operations Research, 179, 15-33. Goud, R., Engen-Verheul, M. van, Keizer, N.F. de, Bal, R.A., Hasman, A., Hellemans, I. & Peek, N. (2010). The effect of computerized decision support on barriers to guideline implementation: A qualitative study in outpatient cardiac rehabilitation. International Journal of Medical Informatics, 79(6), 430-437. Hout, E. van, Stibane, R., Frederiks, B.J.M., Legemaate, J. & Robben, P.B.M. (2010). De Inspectie voor de Gezondheidszorg en het tuchtrecht. Meer uniformiteit bij het indienen van tuchtzaken en minder jaarlijkse fluctuatie in aantal tuchtklachten gewenst. Tijdschrift voor Toezicht, 46-64. Huijsman, R. & Wesseling, M. (2010). Sterke zorg voor kwetsbare oudere. Medisch Contact, 65(16), 710-713. 298

Hulst, E.H. (2010). HR 16 april 2010: is verjaring context-afhankelijk en wordt de schadebeperkingsplicht beperkt door grondrechten? TMA Tijdschrift voor Mileu en aansprakelijkheid, 214-225. Klundert, J.J. van de & Wormer, L. (2010). ASAP: The After-Salesman Problem. Manufacturing and Service Operations Management, 12(4), 627-651. Klundert, J.J. van de & Otten, B. (2010). Improving LTL truck load utilizations on line. European Journal of Operational Research, 210, 336-343. Klundert, J.J. van de, Gorissen, P. & Zeemering, S. (2010). Measuring clinical pathway adherence. Journal of Biomedical Informatics, 43(6), 861-872. Korne, D.F. de, Wijngaarden, J.D.H. van, Hiddema, F., Bleeker, F.G., Pronovost, P.J. & Klazinga, N.S. (2010). Diffusing Aviation Innovations in a Hospital in the Netherlands. Joint Commission Journal on Quality and Patient Safety, 36(8), 339-352. Korne, D.F. de, Sol, J.C.A., Wijngaarden, J.D.H. van, Vliet, E.J. van, Custers, T., Cubbon, M., Spileers, W., Ygge, J., Ang, C.L & Klazinga, N.S. (2010). Evaluation of an international benchmarking initiative in nine eye hospitals. Health Care Management Review, 35(1), 23-35. Korne, D.F. de (2010). Amerika bestaat niet. Zorgvisie Magazine, 4, 23-23. Korne, D.F. de (2010). De kunst van het vergelijken. Zorgvisie Magazine, 1, 13-13. Korne, D.F. de (2010). Doctors Hospital. Zorgvisie Magazine, 3, 19-19. Korne, D.F. de (2010). Geloven in Hopkins. Zorgvisie Magazine, 5, 17-17. Korne, D.F. de (2010). Het verdiende loon. Zorgvisie Magazine, 2, 27-27. Lemmens, K.M.M., Nieboer, A.P., Molken, M.P.M.H. van, Schayck, C.P., Asin, J.D., Dirven, J.A.M. & Huijsman, R. (2010). Application of a theoretical model to evaluate COPD disease management. Bmc Health Services Research, 10(81), 1-10. Makai, P., Koopmanschap, M.A., Bal, R.A. & Nieboer, A.P. (2010). Cost-effectiveness of a pressure ulcer quality collaborative. Cost Effectiveness and Resource Allocation, 8(11), 1-31. Minkman, M.M.N., Ahaus, K. & Huijsman, R. (2010). Het ontwikkelingsmodel voor Ketenzorg. M en O, 5, 26-43. Niazkhani, Z., Pirnejad, H., Sijs, H. van der, Bont, A.A. de & Aarts, J.E.C.M. (2010). Computerized Provider Order Entry System. Methods of Information in Medicine, 49(1), 20-27. Niazkhani, Z., Pirnejad, H., Bont, A.A. de & Aarts, J.E.C.M. (2010). CPOE in Non-Surgical Versus Surgical Specialties: A Qualitative Comparison of Clinical Contexts in the Medication Process. The Open Medical Informatics Journal, 4, 206-213. Nieboer, A.P., Koolman, A.H.E. & Stolk, E.A. (2010). Preferences for long-term care services: Willingness to pay estimates derived from a discrete choice experiment. Social Science & Medicine, 70(9), 1317-1325. Oertle, M. & Bal, R.A. (2010). Understanding non-adherence in chronic heart failure: a mixed-method case study. Quality & Safety in Health Care, 19(37), 1-5. Peute, L.W., Aarts, J.E.C.M., Bakker, P.J.M. & Jaspers, M.W.M. (2010). Anatomy of a failure: A sociothechnical evaluation of a laboratory physician order entry system implementation. International Journal of Medical Informatics, 79(4), 58-70. Schouten, L.M.T., Hulscher, M.E.J.L., Everdingen, J.J.E. van, Huijsman, R., Niessen, L.W. & Grol, R.P.T.M. (2010). Short- and long-term effects of a quality improvement collaborative on diabetes management. Implementation Science, 5(94), 1-10. Sijs, H. van der, Bouamar, R., Gelder, T. van, Aarts, J.E.C.M., Berg, M. & Vulto, A.G. (2010). Functionality test for drug safety alerting in computerized physician order entry systems. International Journal of Medical Informatics, 79(4), 243-251. Sijs, H. van der, Gelder, T. van, Vulto, A., Berg, M. & Aarts, J.E.C.M. (2010). Understanding Handling of Drug Safety Alerts: a Simulation Study. International Journal of Medical Informatics, 79, 361-369. Staa, A.L. van, Jedeloo, S, Latour, J.M. & Trappenburg, M.J. (2010). Exciting but exhausting: experiences with participatory research with chronically ill adolescents. Health Expectations, 13(1), 95-107. Staa, A.L. van (2010). Managing transition. Support for individuals at key point of change. International Journal of Integrated Care, 10, 1-2. Staa, A.L. van & Adams, S.A. (2010). Internet & kwalitatief onderzoek. KWALON. Tijdschrift voor Kwalitatief Onderzoek in Nederland, 15(2), 3-11. Staa, A.L. van, Havers, J. & Sonneveld, H.M. (2010). Overstappen; Transitie van chronisch zieke jongeren. Tijdschrift voor Kindergeneeskunde, 1, 4-5. Staa, A.L. van, Eysink Smeets - van de Burgt, A.E., Stege, H.A. van der & Hilberink, S.R. (2010). Transitie in zorg van jongeren met chronische aandoeningen in Nederland nog onder de maat. Tijdschrift voor Kindergeneeskunde, 78(6), 227-236. 299

Steenkamer, B., Goede, J. de, Treurniet, H.F., Putters, K. & Oers, H. van (2010). Het gebruik van (volks)gezondheidsinformatie door beleidsmakers: een studie in Midden-Holland. TSG, 88(8), 461-469. Stege, H.A. van der, Staa, A.L. van, Hilberink, S.R. & Visser, A.Ph. (2010). Using the new board game SeCZ TaLK to stimulate the communication on sexual health for adolescents with chronic conditions. Patient Education and Counseling, 81(3), 324-331. Stege, H.A. van der, Staa, A.L. van, Vonk, M.R., Jedeloo, S & Visser, A.Ph. (2010). Analyse van voor- en achternamen voor bepalen van respons van allochtone jongeren: een bruikbare methode? TSG, 88(3), 70-70. Stege, H.A. van der & Staa, A.L. van (2010). Let's talk about sex - ontwikkeling van en eerste ervaringen met SeCZ TaLK, bordspel voor chronisch zieke jongeren. Tijdschrift voor Kindergeneeskunde, 78(1), 91-92. Stepaniak, P.S., Heij, C. & Vries, G. de (2010). Modeling and prediction of surgical procedure times. Statistica Neerlandica, 64(1), 1-18. Stepaniak, P.S., Vrijland, W.W., Quelerij, M. & Vries, G. de (2010). Working With a Fixed Operating Room Team on Consecutive Similar Cases and the Effect on Case Duration and Turnover Time. Archives of Surgery, 145(12), 1165-1170. Strating, M.M.H. & Nieboer, A.P. (2010). Norms for creativity and implementation in healthcare teams: testing the group innovation inventory. International Journal for Quality in Health Care, 22(4), 275-282. Veld, M.F.A., Paauwe, J. & Boselie, P. (2010). HRM and strategic climates in hospitals: does the message come across at the ward level? Human Resource Management Journal, 20(4), 339-356. Vliet, E.J. van, Reus, N.J., Sermeus, W., Vissers, J.M.H., Sol, J.C.A. & Lemij, H.G. (2010). Patients' experiences and preferences with co-managed care in a cataract pathway. British Journal of Ophthalmology, 94(10), 1363-1368. Wauben, L.S.G.L., Goossens, R., Lange, J. & Dekker - van Doorn, C.M. (2010). Blackbox, checklists en ergonomie. Meervoudige benadering. OK Management, 2, 14-17. Wauben, L.S.G.L. & Dekker - van Doorn, C.M. (2010). TOPplus: Team Checks in de Operatiekamer. Tijdschrift voor Ergonomie, 35(6), 5-11. Wetering, E.J. van de, Lemmens, K.M.M., Nieboer, A.P. & Huijsman, R. (2010). Cognitive and behavorial interventions for the management of chronic neuropathic pain in adults - A systematic review. European Journal of Pain, 14(7), 670-681. Winters, S., Strating, M.M.H., Klazinga, N.S., Kool, R.S.B. & Huijsman, R. (2010). Determining the interviewer effect on CQ Index outcomes: a multilevel approach. BMC Medical Research Methodology, 10(75), 1-25. Zuiderent, T. (2010). Embodied Interventions-Interventions on Bodies: Experiments in Practices of Science and Technology Studies and Hemophilia Care. Science, Technology & Human Values, 35(5), 677-710. Zuiderent, T., Grit, K.J. & Grinten, T.E.D. van der (2010). Zorgmarkten en publieke belangen. B en M, 37(3), 221-231. Inaugurale rede Klein, J. (2010). Tussen de modder van de praktijk en de schone wetenschap. Oratie (2010, november 26). Rotterdam: eigen beheer. Robben, P.B.M. (2010). Toezicht in een glazen huis. Effectiviteit van het toezicht op de kwaliteit van de gezondheidszorg. oratie (2010, juli 01). Rotterdam: eigen beheer. Boek - monografie - boekredactie Aarts, J.E.C.M. & Nøhr, C. (2010). From Safe Systems to Patient Safety (Studies in Health Technology and Informatics, 157). Amsterdam: IOS Press. Bekker, M.P.M. & Veerman, L. (2010). Gezondheidseffectschatting: wetenschappelijke onderbouwing en beleidscoordinatie van intersectoraal gezondheidsbeleid. Assen: Koninklijke Van Gorkum. Schreiner, N.A.F.M. (2010). Loopbaan- en talentontwikkeling voor het individu. Rotterdam: Uitgave in eigen beheer. Part of book - abstract Bal, R.A., Büscher, M., Goodwin, D., Mesman, J., Sangiorgi, D. & Smith, A. (2010). Moving towards a New View of Diagnostic Work: Some Implications. In Ethnographies of Diagnostic Work (pp. 245/260-14). Basingstoke UK: Palgrave Macmillan. Buijsen, M.A.J.M. (2010). Inleiding (gezondheidsrecht). In H.E.G.M. Hermans & M.A.J.M. Buijsen (Eds.), Recht en Gezondheidszorg (pp. 23-1). Amsterdam: Elsevier Gezondheidszorg. Buijsen, M.A.J.M. (2010). Kwaliteitsregulering in de gezondheidszorg. In H.E.G.M. Hermans & M.A.J.M. Buijsen (Eds.), Recht en Gezondheidszorg (pp. 179-4). Amsterdam: Elsevier Gezondheidszorg. Rapport Bont, A.A. de, Wallenburg, I., Mulder, H., Scheele, F. & Meurs, P.L. (2010). Eenvoud in Veelvoud. Utrecht: CBOG. Wallenburg, I. (2010). Een Hobbelige Opleiding: Drempels, Kansen en Strategieën in het Medisch Opleidingstraject. : Koninklijke Broese & Peereboom. 300

EMC NIHES-05-63-02 - Quality and efficiency in health care (theme 2) Programme in brief design The programme health technology assessment, which is organised and carried out within imta, has grown considerably in the period '97/2004. An important impetus at the start of the development in this period was a large grant from the Ministry of Health for imta to support medical associations in their development of practice guidelines. In these guidelines for medical practice not only effectiveness but also the cost-effectiveness of various preventive or curative strategies is considered when making recommendations on how to deal with a specific health problem. Furthermore, important methodological topics have been studied, such as the measurement and valuation of productivity costs, the analysis of models describing patients' preferences, the valuation of informal care in economic evaluation, statistical methods of economic evaluation, efficacy-effectiveness issues, and valuation of quality of life. The NWO-subprogram on methodology of 'health technology assessment' as part of the larger program on cost effectiveness of health care programs provided the opportunity to carry out new methodological projects. Furthermore, a large number of practical, often international, projects have been carried out for various diseases and health care programs. An innovative example is a large multinational trial on the management of BPH-treatment in 6 European countries. This is the first large-scale naturalistic prospective economic evaluation in Europe. Finally, a number of projects in low-income countries have been carried out, some of which in close cooperation with WHO Geneva. Almost 100% of the research in this programme is externally funded Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot HPM-Bedrijfsvoering voor zorgorganisaties 0 0,75 0 0,25 1 HPM-Gezondheidseconomie 5,87 13,4 0 28,45 47,72 HPM-Health Care Governance 0,3 0,25 0 1,24 1,79 Total 6,17 14,4 0 29,94 50,51 0 0 0 0 79 26 29 134 Artikel/Letter to the editor Abdellaoui, M., Attema, A.E. & Bleichrodt, H. (2010). Intertemporal tradeoffs for gains and losses: an experimental measurement of discounted utility. The Economic Journal, 120(545), 845-866. Al, M.J., Hakkaart-van Roijen, L., Tan, S.S. & Bakker, J. (2010). Cost-consequence analysis of remifentanil-based analgosedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands. Journal of Critical Care, 14(195), 1-10. Al-Janabi, H., Frew, E., Brouwer, W.B.F., Rappange, D.R. & Exel, N.J.A. van (2010). The inclusion of positive aspects of caring in the Caregiver Strain Index: Tests of feasibility and validity. International Journal of Nursing Studies, 47, 984-993. Attema, A.E., Lugnér, A.K. & Feenstra, T.L. (2010). Investment in antiviral drugs: a real options approach. Health Economics, 19, 1240-1254. Attema, A.E. & Brouwer, W.B.F. (2010). On the (not so) constant proportional trade-off in TTO. Quality of Life Research, 19, 489-497. Attema, A.E. & Brouwer, W.B.F. (2010). The Value of Correcting Values: Influence and Importance of Correcting TTO Scores for Time Preference. Value in Health, 13(8), 879-884. Attema, A.E., Bleichrodt, H., Rohde, K.I.M. & Wakker, P.P. (2010). Time-Tradeoff Sequences for Analyzing Discounting and Time Inconsistency. Management Science, 56(11), 2015-2030. Baal, P.H.M. van, Hoogenveen, R.T., Boshuizen, H.C. & Engelfriet, PM (2010). Indirect Estimation of Chronic Disease Excess Mortality. Epidemiology, 21(3), 1-2. Baal, P.H.M. van & Feenstra, T.L. (2010). Long-term effects of alcohol policies: an economic perspective. Addiction, 105, 395-396. Baal, P.H.M. van (2010). Economische evaluaties en de zorgkosten van levensverlenging. VGE Bulletin, 3, 26-28. Baeten, S.A., Baltussen, R.M.P.M., Uyl - de Groot, C.A., Bridges, J. & Niessen, L.W. (2010). Incorporating Equity-Effeciency Interactions in Cost-Effectiveness Analysis-Three Approaches Applied to Breast Cancer Control. Value in Health, 13(5), 573-579. Baeten, S.A., Exel, N.J.A. van, Dirks, M., Koopmanschap, M.A., Dippel, D.W.J. & Niessen, L.W. (2010). Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach. Cost Effectiveness and Resource Allocation, 8(21), 1-10. Baker, R., Exel, N.J.A. van, Mason, H. & Stricklin, M. (2010). Connecting Q & Surveys: Three Methods to Explore Factor Membership in Large Samples. Operant Subjectivity, 34(1), 38-58. Berghout, C.C., Zevalkink, J. & Hakkaart-van Roijen, L. (2010). A cost-utility analysis of psychoanalysis versus psychoanalytic psychotherapy. International Journal of Technology Assessment in Health Care, 26(1), 3-10. Bleichrodt, H. & Filko, M. (2010). A Reply to Gandjour and Gafni. Journal of Health Economics, 29(2), 329-331. 301

Bobinac, A., Exel, N.J.A. van, Rutten, F.F.H. & Brouwer, W.B.F. (2010). Caring for and caring about: Disentangling the caregiver effect and the family effect. Journal of Health Economics, 29, 549-556. Bobinac, A., Exel, N.J.A. van, Rutten, F.F.H. & Brouwer, W.B.F. (2010). Willingness to Pay for a Quality-Adjusted Life-Year: The Individual Perspective. Value in Health, 13(8), 1049-1055. Boormans, E.M.A., Birnie, E., Knegt, A.C., Schuring-Blom, GH, Bonsel, G.J. & Lith, J.M. van (2010). Aiming at multidisciplinary consensus: what should be detected in prenatal diagnosis? Prenatal Diagnosis, 30, 1049-1056. Boormans, E.M.A., Birnie, E., Oepkes, D., Galjaard, R.J.H., Schuring-Blom, G.H. & Lith, J.M. van (2010). Comparison of Multiplex Ligation-Dependent Probe Amplification and Karyotyping in Prenatal Diagnosis. Bjog-An International Journal of Obstetrics and Gynaecology, 115(2), 297-303. Boormans, E.M.A., Birnie, E., Oepkes, D., Boekkooi, P.F., Bonsel, G.J. & Lith, J.M.M. van (2010). Individualized choice in prenatal diagnosis: the impact of karyotyping and standalone rapid aneuploidy detection on quality of life. Prenatal Diagnosis, 30, 928-936. Boormans, E.M.A., Birnie, E., Oepkes, D., Bilardo, C.M., Wildschut, H.I.J., Creemers, J., Bonsel, G.J. & Lith, J.M. van (2010). The impact of rapid aneuploidy detection (RAD) in addition to karyotyping versus karyotyping on maternal quality of life. Prenatal Diagnosis, 30, 425-433. Brouwer, W.B.F. & Rutten, F.F.H. (2010). The efficiency frontier approach to economic evaluation: will it help German policy making? Health Economics, 19, 1128-1131. Buijsen, M.A.J.M. (2010). Autonomy, Human Dignity, and the Right to healthcare: A Dutch Perspective. Cambridge Quarterly of Healthcare Ethics, 19(3), 321-329. Buijsen, M.A.J.M. (2010). Autonomie en rechtvaardigheid in de gezondheidszorg. Pro Vita Humana, 17(1), 12-18. Buijsen, M.A.J.M. (2010). De rechtvaardige verdeling van gezondheidszorg. 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(2010). Efficacy and cost-effectiveness of nutritional intervention in elderly after hip fracture: design of a randomized controlled trial. Bmc Public Health, 10(212), 1-6. Boek - monografie - boekredactie Molken, M.P.M.H. van, Groot, C.A. de & Rutten, F.F.H. (2010). Een handleiding voor economische evaluatiestudies in de gezondheidszorg Tweede herziene druk. Amsterdam: Elsevier. Part of book - abstract Adams, S.A. (2010). Use of 'serious health games' in health care: a review. From Safe Systems ot Patient Safety. In C. Nohr & J. Aarts (Eds.), Information Technology in Health Care: Socio-Technical Approaches 2010 (Studies in Health Technology and Informatics, 157) (pp. 160-166). IOS Press. Bekker, M.P.M. & Goede, J. de (2010). Policy. In A. Haveman-Nies, S. Jansen, H. van Oers & P. van 't Veer (Eds.), Epidemiology in public health practice (pp. 275/13-303/13). Wageningen: Wageningen Academic Publishers. Bleichrodt, H. & Brouwer, W.B.F. (2010). Disconteren. In M. Rutten-Van Mölken, F.F.H Rutten & C.A. Uyl-De Groot (Eds.), Van Kosten Tot Effecten Een Handleiding Voor Evaluatiestudies in De Gezondheidszorg (pp. 8-9). Maarssen: Elsevier Gezondheidszorg. Brouwer, W.B.F. (2010). Perspective, costs, outcome and discounting in pharmacoeconomic evaluations. In F.F.H. Rutten & A.G. Vulto (Eds.), PharmacoEconomics for European hospital pharmacists (pp. 12-1). Mol, Belgie: Pharma Publishing and Media Europe. Brouwer, W.B.F. & Koopmanschap, M.A. (2010). Overige kosten binnen en buiten de gezondheidszorg. In M. Rutten-Van Mölken, F.F.H Rutten & C.A. Uyl-De Groot (Eds.), Van Kosten Tot Effecten Een Handleiding Voor Evaluatiestudies in De Gezondheidszorg (pp. 19-4). Maarssen: Elsevier Gezondheidszorg. Buijsen, M.A.J.M. (2010). Filosofie & Praktijk: praktische problemen in filosofisch perspectief. In Filosofie en Praktijk (Filosofie & Praktijk, 3) (pp. 51-5). Budel: Damon. Doorslaer, E.K.A. van & O'Donnell, O.A. (2010). Measurement and explanation of inequality in health and health care in lowincome settings. In M. McGillivray, I. Dutta & D. Lawson (Eds.), Health inequality and development, Studies in Development Economics and Policy (pp. 20-2). Basingstoke: Palgrave McMillan. Evers, J.C. & Staa, A.L. van (2010). Qualitative Analysis in Case Study. In A. Mills, G. Durepos & W. Elden (Eds.), Encyclopedia of Case Study Research (pp. 749-757). Thousand Oaks, Ca.: Sage Publications. Halffman, W. & Bal, R.A. (2010). Regulatory Futures in Retrospect. In J. Eriksson, M. Gilek & C. Ruden (Eds.), Regulating Chemical Risks (pp. 19/340-19/348). Dordrecht: Springer. Jansen, Y.J.F.M. (2010). The Taming of Chance and the Actual Practice of Prevention; Rationalised Prevention and >the social<. In T. Mathar & Y.J.F.M Jansen (Eds.), Health Promotion and Prevention Programmes in Practice. How Patients' Health Practices are Rationalised, Reconceptualised and Reorganised (pp. 147). Bielefeld: Transcript Verlag. 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Rutten, F.F.H. & Vulto, A.G. (2010). Pharmacoeconomics for European hospital pharmacists. In M. Gallacher & E. Kurt (Eds.), European Journal of Hospital Pharmacy Practice. Mol, Belgie: Pharma Publishing and Media Europe. Zuiderent, T. & Berg, M. (2010). The Sociology of Quality and Safety in Health Care. Studying a Movement and Moving Sociology. In C.E. Bird, P. Conrad, A.M. Fremont & S. Timmermans (Eds.), Handbook of Medical Sociology; Sixth Edition (pp. 19/324-19/336). Nashville: Vanderbilt University Press. Boekbespreking Buijsen, M.A.J.M. (2010). B.C. van Beers, persoon en lichaam in het recht. Menselijke waardigheid en zelfbeschikking in het tijdperk van de medische biotechnologie [Bespreking van het boek Persoon en lichaam in het recht. Menselijke waardigheid en zelfbeschikking in het tijdperk van de medische biotechnologie]. Rechtsgeleerd Magazijn Themis, 171, 144-147. Buijsen, M.A.J.M. (2010). B.C. van Beers, persoon en lichaam in het recht. Menselijke waardigheid en zelfbeschikking in het tijdperk van de medische biotechnologie [Bespreking van het boek Persoon en lichaam in het recht. Menselijke waardigheid en zelfbeschikking in het tijdperk van de medische biotechnologie]. Rechtsfilosofie en Rechtstheorie, 39(2), 179-183. Rapport Lips, E.J.I., Molken, M.P.M.H. van, Hoogeveen, R, Al, M.J. & Feenstra, T.L. (2010). Comparing the cost-effectiveness of a wide range of COPD interventions using a stochastic, dynamic, population model for COPD. Rotterdam: ibmg. Polain, M. le, Franken, M.G., Koopmanschap, M.A. & Cleemput, I. (2010). Drug reimbursement systems: international comparison and policy recommendations. KCE Reports 147C. Brussel: Federaal Kenniscentrum voor de gezondheidszorg - Centre fédéral d'expertise des soins de santé. Stolk, E.A. & Brouwer, W.B.F. (2010). Communicatie en Implementatieplan (CIP) voor het Deelprogramma HTA methodologie onder het hoofdprogramma Doelmatigheidsonderzoek Farmacotherapie. Rotterdam: IMTA. 307

EMC NIHES-05-63-03 - Competition and regulation in health care (theme 1) Programme in brief design The programme "structure and finance of health care" has a strong economic perspective as well as a judicial perspective. Research focuses on some fundamental aspect of the market-oriented health care reforms that are taking place in the Netherlands as well as in many other countries. The risk-adjuster "Pharmacy Cost Group", developed by the health economics group, is considered to be in the forefront of the international risk adjustment research. The Dutch government has implemented this new risk-adjuster in the Dutch health insurance system in 2002. Research activities are currently dealing with the following topics: structure of health care systems, legal aspects of health care reform, uncertainty and equilibrium on the market for health insurers, regulated competition in health care, competition policy, risk adjusted premium subsidies for health insurance, determinants of consumer choice of health plan, consumer information, bonuses for GPs, equity in the finance and delivery of health care and the consequences of the European Union for structure and finance for the Dutch Health care system. The research programme on "equity in health and health care" focuses on the national and international assessment of health equity and inequality. The scope of the research activities has broadened over the period under consideration from the developed world (OECD countries) to the less developed world. In collaboration with the World Bank the methods for measuring inequality and inequity have been adapted to low-income countries and equity objectives, and have been applied to data from a number of developing nations. The measurement methods of the ECuity Project, which is co-ordinated by the group, have now become adopted as a worldwide standard for assessing the equity performance of health systems and the consequences of reforms, as witnessed by their adoption or explicit reference in all major efforts at system (equity) performance evaluation such as the Rockefeller Foundation's Global Health Equity Initiative, the WHO's World Health Report, the World Bank's World Development Report and the OECD's Framework for Health System Performance Key figures Department SP1 SP2 SP3 SP4 Sptot T1 T2 T3 Ttot IS FS OP Ptot HPM-Gezondheidseconomie 0 0 0 1,15 1,15 HPM-Gezondheidsrecht 1,85 0,83 0 0 2,68 HPM-Health Care Governance 1,49 3,05 0 7,7 12,24 HPM- Ziektekostenverzekering 0,42 0,29 0 4,73 5,44 Total 3,76 4,17 0 13,58 21,51 3 1 0 4 10 13 27 54 Thesis Bovenkamp, H.M. van de (2010, november 04). The limits of patient power. Examining active citizenship in dutch healt care. EUR (179 pag.) (Rotterdam: Optima Grafische Communicatie). Prom./coprom.: Prof.Dr. M.J. Trappenburg. Egmond, C. van (2010, december 09). Science and policy in interaction. EUR. Prom./coprom.: Prof.Dr. R.A. Bal. Jeurissen, P.P.T. (2010, mei 27). For-Profit Hospitals. A comparative and longitudinal study of the for-profit hospital sector in four Western countries. EUR (326 pag.) (Rotterdam: Optima Grafische Communicatie bv). Prom./coprom.: Prof.Dr. T.E.D. van der Grinten & Prof.Dr. F.T. Schut. Varkevisser, M. (2010, januari 14). Patient choice, competition and antitrust enforcement in Dutch hospital markets. EUR (174 pag.) (Rotterdam: Optima Grafische Communicatie bv). Prom./coprom.: Prof.Dr. F.T. Schut. Annotatie Hulst, E.H. (2010). Noot bij: 's-hertogenbosch. (20-07-2010), TMA 2010-4, HD 200.041.998), (Specifiteitsvereiste door het Hof afgezwakt). p.196-198. Hulst, E.H. (2010). Noot bij: RB Leeuwarden. (21-07-2010), TMA 2010-4, 92832/HA ZA 08-912,, (Conformiteitsvereiste, de plicht te reageren "binnen bekwame tijd" en de rol van een slechte reputatie). p.185-191. Artikel/Letter to the editor Armstrong, J., Paolucci, F., McLeod, H.L. & Ven, W.P.M.M. van de (2010). Risk equalisation in voluntary health insurance markets: A three country comparison. Health Policy, 98, 39-49. Armstrong, J.S., Paolucci, F. & Ven, W.P.M.M. van de (2010). Risk equalisation in voluntary health insurance markets. Health Policy, 98, 1-2. Bekker, M.P.M., Egmond, C. van, Wehrens, R.L.E., Putters, K. & Bal, R.A. (2010). Linking research and policy in Dutch healthcare: infrastructure, innovations and impacts. Evidence & Policy, 6(2), 237-253. Bevan, G. & Ven, W.P.M.M. van de (2010). Choice of providers and mutual healthcare purchasers: can the English National Health Service learn from the Dutch reforms? Health Economics, Policy and Law, 5, 343-363. Bovenkamp, H.M. van de, Trappenburg, M.J. & Grit, K.J. (2010). Patient participation in collective healthcare decision making: the Dutch model. Health Expectations, 13, 73-85. Bovenkamp, H.M. van de & Trappenburg, M.J. (2010). The relationship between mental health workers and family members. Patient Education and Counseling, 80, 120-125. 308

Buijsen, M.A.J.M. (2010). De bijzondere morele status van gezondheidszorg. Over marktwerking, gelijke behandeling en de noodzaak van zeggenschap. Filosofie en Praktijk, 51-64. Dixon, A.K., Robertson, R. & Bal, R.A. (2010). The experience of implementing choice at point of referral: a comparison of the Netherlands and England. Health Economics Policy and Lauw, 295-317. Egmond, C. van & Zeiss, R. (2010). Modeling for Policy. Schience-based models as perfomative boundary objects for Dutch policy making. Science Studies, 23(1), 58-78. Exter, A.P. den (2010). Health System Reforms in The Netherlands: From Public to Private and its Effects on Equal Access to Health Care. European Journal of Health Law, 17, 223-233. Geest, S.A. van der & Varkevisser, M. (2010). Keuzebeïnvloeding via eigen risico werkt, maar kan beter. TPEdigitaal, 4(4), 34-48. Geest, S.A. van der & Varkevisser, M. (2010). Winstverbod ziekenhuizen onder voorwaarden loslaten. Economisch-Statistische Berichten, 95(4580), 152-154. Hermans, H.E.G.M., Muijsers, L. & Scholten, G.R.M. (2010). Wetgever zet besturing zorginstellingen onder druk. Zorg en Financiering, 11-21. Hulst, E.H. (2010). Wat kan je doen als je van clienten veel klachten krijgt over een bepaalde tandarts? Wat is de procedure als een patient een klacht wil indienen? Mondhygienisten Vademecum, 8(3), 1-3. Jedeloo, S., Staa, A.L. van, Latour, J.M. & Exel, N.J.A. van (2010). Preferences for health care and self-management among Dutch adolescents with chronic conditions: A Q-methodological investigation. International Journal of Nursing Studies, 47, 593-603. Kleef, R.C. van, Beck, K. & Buchner, F. (2010). Risk-Type Concentration and Efficiency Incentives: A Challenge for the Risk Adjustment Formula. The Geneva Papers, 35, 503-520. Kleef, R.C. van, Ven, W.P.M.M. van de & Vliet, R.C.J.A. van (2010). Een solidair eigen risico in de zorg. Economisch- Statistische Berichten, 95(4592), 522-524. Loozen, E.M.H. (2010). The workings of article 101 TFEU in case of an agreement tat aims to limit parallel trade (GlaxoSmithKline Services (C-501/06 P, C-513/06P, C-515/06 P and C-519/06 P). European Competition Law Review, 9, 349-353. Noord, T.J.C. van (2010). De eerste Nederlandse farmacopee. TMA Tijdschrift voor Mileu en aansprakelijkheid, 24(3), 80-88. Noord, T.J.C. van (2010). De rook is nog niet opgetrokken : het rookverbod in de horeca. TMA Tijdschrift voor Mileu en aansprakelijkheid, 154-170. Noord, T.J.C. van (2010). Gezondheidsrecht op zijn plaats in TMA. TMA Tijdschrift voor Mileu en aansprakelijkheid, 24(1), 5-11. Schut, F.T. & Berg, B. van den (2010). La sostenibilità del sistema di assicurazione universale per il long-term care nei Paesi Bassi. Politiche Sanitarie, 11(2), 98-112. Schut, F.T. & Berg, B van den (2010). Sustainability of Comprehensive Universal Long-term Care Insurance in the Netherlands. Social Policy & Administration, 44(4), 411-435. Schut, F.T. (2010). Marktwerking in de zorg: waar gaat het eigenlijk over? Nederlands Tijdschrift voor Geneeskunde, 154(B589). Schut, F.T., Ven, W.P.M.M. van de & Varkevisser, M. (2010). Prijsconcurrentie gaat niet samen met macrobudget ziekenhuizen. Economisch-Statistische Berichten, 95(4587), 374-376. Schut, F.T. & Ven, W.P.M.M. van de (2010). Structuur Duitse zorgpremies efficienter dan Nederlandse. Economisch- Statistische Berichten, 95(4596), 662-665. Schut, F.T. & Ven, W.P.M.M. van de (2010). Uitvoering AWBZ door zorgverzekeraars onverstandig. Economisch-Statistische Berichten, 95(4591), 486-489. Stam, P.J.A., Vliet, R.C.J.A. van & Ven, W.P.M.M. van de (2010). A limited-sample benchmark approach to assess and improve the performance of risk equalization models. Journal of Health Economics, 29, 426-437. Stam, P.J.A., Vliet, R.C.J.A. van & Ven, W.P.M.M. van de (2010). Diagnostic, Pharmacy-Based, and Self-Reported Health Measures in Risk Equalization Models. Medical Care, 48(5), 448-455. Swierstra, T., Bovenkamp, H.M. van de & Trappenburg, M.J. (2010). Forging a fit between technology and morality: The Dutch debate on organ transplants. Technology in Society, 32, 55-64. Varkevisser, M., Geest, S.A. van der & Schut, F.T. (2010). Assessing hospital competition when prices don't matter to patients: the use of time-elasticities. International Journal of Health Care Finance and Economics, 10(1), 43-60. Varkevisser, M. & Schut, F.T. (2010). Fusietoetsing in de zorg. Economisch-Statistische Berichten, 95(4576), 22-25. 309

Ven, W.P.M.M. van de & Schut, F.T. (2010). Fout van CPB bij berekening remgeldeffect eigen risico. TPEdigitaal, 4(2), 153-157. Ven, W.P.M.M. van de & Schut, F.T. (2010). Is de Zorgverzekeringswet een succes? TPEdigitaal, 4(1), 1-24. Wehrens, R.L.E., Bekker, M.P.M. & Bal, R.A. (2010). The construction of evidence-based local health policy through partnerships: Research infrastructure, process and context in the Rotterdam 'Healthy in the City' programme. Journal of Public Health Policy, 31(4), 447-460. Boek - monografie - boekredactie Exter, A.P. den (2010). International Trade Law and Health Care. Rotterdam: Erasmus University Press. Hermans, H.E.G.M. & Buijsen, M.A.J.M. (2010). Recht en Gezondheidszorg. Amsterdam: Elsevier Gezondheidszorg. Noord, T.J.C. van (2010). Wet- en regelgeving in de zorg (Preventiewetgeving en wetgeving publieke gezondheidszorg, 12). Eindhoven: SBO. Part of book - abstract Adams, S.A. (2010). Sourcing the Crowd for Health Experiences: Leting the People Speak of Obliging Voice Through Choice? In R. Harris, N. Wathen & S. Wyatt (Eds.), Configuring Health Consumers Health Work and the Imperative of Personal Responsibility (Series Standing Order) (pp. 179/12-193/12). Basingstoke: Palgrave Macmillan. Boonen, L.H.H.M., Geest, S.A. van der, Schut, F.T. & Varkevisser, M. (2010). Pharmaceutical Policy in the Netherlands: from price regulation towards managed competition. In Pharmaceutical markets and Insurance Worldwide (Advances in Health Economics and Health Services Research, 22) (pp. 53). Bingley: Emerald Group Publishing Limited. Buijsen, M.A.J.M. & Akveld, J.E.M. (2010). Bijzondere patiëntenrechten in de gezondheidszorg. In H.E.G.M Hermans & M.A.J.M Buijsen (Eds.), Recht en Gezondheidszorg (pp. 259-7). Maarssen: Elsevier. Buijsen, M.A.J.M. (2010). Rechtshandhaving in de gezondheidszorg. In H.E.G.M Hermans & M.A.J.M Buijsen (Eds.), Recht en Gezondheidszorg (pp. 593). Maarssen: Elsevier. Noord, T.J.C. van (2010). Openbare gezondheid en preventie. In H.E.G.M. Hermans & M.A.J.M Buijsen (Eds.), Recht en gezondheidszorg (pp. 461). Maarssen: Elsevier. Noord, T.J.C. van (2010). Preventiewetgeving en wetgeving openbare gezondheidszorg. In M.A.J.M. Buijsen & H.E.G.M. Hermans (Eds.), Wet- en regelgeving in de zorg (pp. 5/12-49/12). Euroforum. Schut, F.T. & Kam, C.A. de (2010). Het budgettaire zorgenkind. In C.A. de Kam, J.H.M Donders & A.P. Ros (Eds.), Miljardendans in Den Haag (pp. 89-6). Den Haag: SDU Uitgevers. Rapport Schut, F.T. & Ven, W.P.M.M. van de (2010). Leidt uitvoering door concurrerende zorgverzekeraars tot een doelmatige en financieel houdbare AWBZ? NEA Papers 32. Tilburg: Netspar - Universiteit van Tilburg. Varkevisser, M. & Schut, F.T. (2010). Ziekenhuisfusies en concurrentie in het Nederlandse zorgstelsel. SMO Publicaties 2009 5/6. Den Haag: SMO - Stichting Maatschappij en Onderneming. 310