COST COMPARISON CHARTS July 2015

Transcription

1 REGIONAL DRUG AND THERAPEUTICS CENTRE (NEWCASTLE) COST COMPARISON CHARTS July 2015 INTRODUCTION 16/17 Framlington Place Newcastle upon Tyne NE2 4AB Charts are organised by BNF classification and show comparative costs at basic NHS prices (as of July 2015) for selected agents. Except where indicated otherwise, each chart shows the cost of 1 year 1 of treatment at a standard daily dose (shown in brackets). The doses given are not intended to imply therapeutic equivalence and for some drug groups such as ACE inhibitors doses may vary according to indication. Additionally, in some therapeutic areas such as antibacterial drugs the duration of treatment may differ from that shown. NEW - are now available in Excel format to all stakeholders (under password protection) on our NHS website: The contents table on the following page has been formatted so that you can quickly navigate to specific charts by holding the cursor over the chart title and clicking your left mouse button whilst holding down the Ctrl key. NOT TO BE USED FOR COMMERCIAL OR MARKETING PURPOSES 1 1 year in this case is equal to 364 days rather than 365 when 1 month equals 28 days.

2 To navigate to the chart required, hover the cursor over the section required, press CTRL and click with the left mouse button. CONTENTS by BNF classification Page Dyspepsia and gastro-oesophageal reflux disease Antispasmodics and other drugs altering gut motility Antisecretory drugs and mucosal protectants Acute Diarrhoea Laxatives Diuretics Beta-adrenoceptor blocking drugs Alpha-adrenoceptor blocking drugs Drugs affecting the renin-angiotensin system /2.6.3 Nitrates and other antianginal drugs Calcium-channel blockers Oral anticoagulants Antiplatelet drugs Lipid-regulating drugs Bronchodilators Corticosteroids Corticosteroid & bronchodilator inhalers & 3.2 Inhaled therapy licensed for COPD Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase type-4 inhibitors Antihistamines Hypnotics & anxiolytics Atypical antipsychotics maintenance doses (adults with psychosis) Atypical antipsychotics Low doses Antidepressant drugs Drugs used in the treatment of obesity Drugs used in nausea and vertigo Analgesics Opioid analgesics MR Opioid analgesics Strong opioid analgesics equipotent dose cost per 24 hours Neuropathic pain Antimigraine drugs (acute) Antiepileptic drugs Nicotine dependence Drugs for dementia Miscellaneous antimicrobial and anthelmintic drugs Jul 2015

3 5.1.1 Penicillins Cephalosporins Tetracyclines Quinolones Miscellaneous antifungal drugs (including topical and gynaecological) Insulins (prefilled pens and cartridges) Needles For Pre-Filled And Reusable Insulin Pens Blood lancets Blood glucose monitoring Antidiabetic drugs Antidiabetic drugs Newer agents Bisphosphonates and other drugs affecting bone metabolism Contraceptives Combined hormonal contraceptives Contraceptives Progestogen-only contraceptives Drugs for urinary retention Drugs for urinary frequency, enuresis and incontinence Drugs for erectile dysfunction Calcium and vitamin D Non-steroidal anti-inflammatory drugs Rubefacients, topical NSAIDs, capsaicin, and poultices Treatment of Glaucoma Tear Deficiency, Ocular Lubricants, and Astringents Nasal steroids Emollients (by volume) Emollients per 100g/ml Emollient bath and shower preparations per 100g/ml Jul 2015

4 1.1.1 Dyspepsia and gastro-oesophageal reflux disease July 2015: Dyspepsia and gastro-oesophageal reflux disease - cost of 1 year's treatment Maalox Plus (30 ml) Compound alginate suspension (Gastrocote 40 ml) Compound alginate suspension (Gaviscon Advance 20 ml) Co-magaldrox 195/220 suspension (Maalox 30 ml) Compound alginate suspension (Acidex 40 ml) Magnesium Trisilicate suspension (30 ml) Co-magaldrox 195/220 suspension (Mucogel 30 ml) Compund alginate suspension (Peptac 40 ml) Asilone (30 ml) Antispasmodics and other drugs altering gut motility July 2015: Antispasmodics and other drugs altering gut motility - cost of 1 year's treatment Dicycloverine (30 mg) 1, Fybogel Mebeverine sachets (1 BD) Alverine (60 mg TDS) Propantheline (15 mg TDS) Kolanticon gel (40 ml) Hyoscine butylbromide (20 mg QDS) Peppermint oil (Colpermin ) capsules (1 TDS) Mebeverine (135 mg TDS) Peppermint oil (Mintec ) capsules (1 TDS) Mebeverine MR (200 mg BD) ,000 1,200 1,400 1,600 4 Jul 2015

5 1.3 Antisecretory drugs and mucosal protectants July 2015: Antisecretory drugs and mucosal protectants - cost of 1 year's treatment Famotidine (40 mg OD) Misoprostol (200 micrograms QDS) Nizatidine (300 mg OD) Sucralfate (1 g QDS) Losec tablets (20 mg OD) Omeprazole tablets (20 mg OD) Lansoprazole tablets (30 mg OD) Esomeprazole (20 mg OD) Rabeprazole (20 mg OD) Cimetidine (400 mg BD) Pantoprazole (40 mg OD) Lansoprazole capsules (30 mg OD) Ranitidine (150 mg BD) Ranitidine (300 mg OD) Omeprazole capsules (20 mg OD) Jul 2015

6 1.4 Acute Diarrhoea July 2015: Acute diarrhoea - cost of 5 days treatment Racecadotril 100mg capsules 6.74 Co-phenotrope 2.5mg/0.025mg tablets 4.51 Loperamide 2mg capsules 2.09 Loperamide 2mg tablets 1.51 Codeine 30mg tablets Laxatives July 2015: Laxatives - cost of 14 days treatment Prucalopride 2 mg (Resolor ) Lubiprostone 24mcg (Amitiza 2 daily) Linaclotide 290mcg (Constella ) Sodium citrate enema (Micolette 1 daily) Macrogols (Laxido Orange 2 sachets for 14 days) Macrogols (Movicol 2 sachets for 14 days) Sodium picosulfate 2.5 mg (4 capsules) Sodium picosulfate 5 mg/5 ml oral solution (10 ml) Manevac (8 g) Methylcellulose (2 g) Ispaghula husk (Fybogel 2 sachets) Docusate (200 mg) Sterculia (Normacol 10 g) Glycerol suppository (4 g) Lactulose (20 ml) Senna (15 mg) Bisacodyl (10 mg) Jul 2015

7 2.2 Diuretics July 2015: Diuretics - cost of 1 year's treatment Chlortalidone (50 mg) 1, Triamterene (50 mg) Eplerenone (50 mg) Torasemide (5 mg) Amiloride (5 mg) Co-amilofruse 5/40 (1 tablet) Xipamide (20 mg) Indapamide MR (1.5 mg) Spironolactone (100 mg) Spironolactone (25 mg) Indapamide (2.5 mg) Bumetanide (1 mg) Co-amilozide 5/50 (1 tablet) Co-triamterzide 50/25 (1 tablet) Furosemide (40 mg) Bendroflumethiazide (2.5 mg) ,000 1,200 7 Jul 2015

8 2.4 Beta-adrenoceptor blocking drugs July 2015: Beta-adrenoceptor blocking drugs - cost of 1 year's treatment Timolol (10 mg BD) Acebutolol (400 mg OD) Labetalol (200 mg TDS) Oxprenolol (40 mg QDS) Pindolol (15 mg OD) Nadolol (160 mg OD) Sotalol (160 mg OD) Propranolol (40 mg TDS) Metoprolol (50 mg TDS) Celiprolol (200 mg OD) Nebivolol (5 mg OD) Carvedilol (25 mg OD) Bisoprolol (10 mg OD) Atenolol (50 mg OD) Alpha-adrenoceptor blocking drugs July 2015: Alpha-adrenoceptor blocking drugs - cost of 1 year's treatment Indoramin (100 mg) 1, Prazosin (5 mg) Doxazosin MR (4 mg) Terazosin (5 mg) Doxazosin (4 mg) Doxazosin (2 mg) ,000 1,200 8 Jul 2015

9 2.5.5 Drugs affecting the renin-angiotensin system July 2015: Drugs affecting the renin-angiotensin system - cost of 1 year's treatment Aliskiren (300 mg) Azilsartan medoxomil (40mg) Eprosartan (600 mg) Olmesartan (20 mg) Fosinopril (10 mg) Trandolapril (2 mg) Imidapril (10 mg) Moexipril (15 mg) Perindopril arginine (5 mg) Valsartan (80 mg) Quinapril (20 mg) Irbesartan (150 mg) Telmisartan (40 mg) Captopril (25 mg BD) Perindopril erbumine (4 mg) Candesartan (8 mg) Ramipril capsules (5 mg) Losartan (50 mg) Ramipril tablets (5 mg) Enalapril (10 mg) Lisinopril (10 mg) Jul 2015

10 2.6.1/2.6.3 Nitrates and other antianginal drugs July 2015: Nitrates and other antianginal drugs - cost of 28 days treatment Ranolazine (375mg, 500mg, 750mg BD) Ivabradine (10 mg) Isosorbide dinitrate (20 mg QDS) Transiderm Nitro (5 mg/24 hours) Deponit (5 mg/24 hours) Minitran (5 mg/24 hours) Nitro-Dur (5 mg/24 hours) Isosorbide mononitrate MR tabs (60 mg) Isosorbide mononitrate MR caps (60 mg) 8.86 Nicorandil (20 mg BD) 7.04 Isosorbide mononitrate (40 mg BD) 5.38 Glyceryl trinitrate (500 mcg, 100 tablets) 3.74 Nitrolingual spray (200 dose) 0.48 Glytrin spray (200 dose) 0.46 Nitromin spray (200 dose) Jul 2015

11 2.6.2 Calcium-channel blockers July 2015: Calcium-channel blockers - cost of 1 year's treatment Diltiazem MR tablets (60 mg TDS) Dilzem XL (180 mg) Dilzem SR (90 mg BD) Adizem XL (180 mg) Nifedipine MR tabs (Adalat Retard, 20 mg BD) Adizem SR (90 mg BD) Viazem XL (180 mg) Tildiem Retard (90 mg BD) Nifedipine MR tablets (Adalat LA, 30 mg) Nicardipine (30 mg BD) Zemtard XL (180 mg) Nifedipine MR capsules (20 mg BD) Felodipine MR (5 mg) Verapamil (120 mg BD) Lacidipine (4 mg) Lercanidipine (10 mg) Amlodipine (5 mg) Jul 2015

12 2.8.2 Oral anticoagulants July 2015: Oral anticoagulants - cost of 1 year's treatment Dabigatran 110mg capsules (BD) Dabigatran 150mg capsules (BD) Dabigatran 75mg capsules (BD) Apixaban 5mg (BD) Apixaban 2.5mg (BD) Rivaroxaban 10mg tablets (OD) Edoxaban (Lixiana ) 30mg (OD) Rivaroxaban 15mg tablets (OD) Rivaroxaban 20mg tablets (OD) Edoxaban (Lixiana ) 60mg (OD) Warfarin 500microgram tablets (OD) Warfarin 5mg tablets (OD) Warfarin 3mg tablets (OD) Warfarin 1mg tablets (OD) Antiplatelet drugs July 2015: Antiplatelet drugs - cost of 1 year's treatment Ticagrelor (90mg BD) Prasugrel (10mg OD) Prasugrel (5mg OD) Dipyridamole MR (200mg BD) Asasantin Retard (Aspirin 25mg/Dipyridamole MR 200mg BD) Clopidogrel (75mg OD) Aspirin EC (75mg OD) Aspirin Dispersible (75mg OD) Jul 2015

13 2.12 Lipid-regulating drugs July 2015: Lipid-regulating drugs - cost of 1 year's treatment Ciprofibrate (100 mg) Colesevelam (6 tablets) 1, , Colestipol (20 g) Colestyramine sugar free (12 g) Simvastatin (80 mg) / Ezetimibe (10 mg) Omega-3 Marine Triglycerides (10 g) Simvastatin (40 mg) / Ezetimibe (10 mg) Gemfibrozil (1.2 g) Simvastatin (20 mg) / Ezetimibe (10 mg) Rosuvastatin (40mg) Acipimox (500 mg) Ezetimibe (10 mg) Rosuvastatin (20mg) Atorvastatin chewable tablets (20mg) Rosuvastatin (5, 10 mg) Nicotinic acid (1g) / Laropiprant (20mg) Fenofibrate (200 mg) Atorvastatin chewable tablets (10mg) Bezafibrate MR (400 mg) Fenofibrate (160 mg) Fluvastatin (40 mg) Atorvastatin (80mg) Fluvastatin (20mg) Simvastatin (80 mg) Pravastatin (40 mg) Atorvastatin (40mg) Pravastatin (20 mg) Atorvastatin (20 mg) Atorvastatin (10 mg) Simvastatin (40 mg) Simvastatin (20 mg) ,000 1, Jul 2015

14 3.1 Bronchodilators July 2015: Bronchodilators - cost of 1 year's treatment Indacaterol/glycopyrronium Breezhaler DPI (85mcg/43mcg, 1 act OD) Tiotropium Handihaler refill DPI (18 mcg OD) Tiotropium Respimat SMI (5 mcg OD) Olodaterol/tiotropium Respimat SMI (2.5mcg/2.5mcg, 2 act OD) Aclidinium/formoterol Genuair DPI (340mcg/12mcg, 1 act BD) Vilanterol/Umeclidinium Ellipta DPI (22mcg/55mcg, 1 act OD) Salmeterol Accuhaler DPI (50 mcg BD) Indacaterol inhalation powder caps DPI (150 mcg, 1 act) Salmeterol inhaler MDI (25 mcg, 2 act BD) Aclidinium Genuair DPI (322 mcg, 1 act BD) Umeclidinium Ellipta DPI (65mcg, 1 act OD) Glycopyrronium Breezhaler DPI (50mcg, 1 act) Olodaterol Respimat SMI (2.5mcg, 2act OD) Formoterol Turbohaler DPI (6 mcg BD) Formoterol Easyhaler (12 mcg, 1 act BD) Terbutaline Turbohaler DPI (500 mcg, 1 act QDS) Salamol Easi-Breathe MDI (100 mcg, 2 act QDS) Airomir Autohaler MDI (100 mcg, 2 act QDS) Ipratropium inhaler MDI (20 mcg, 2 act QDS) Salbutamol dry powder inhaler DPI (200 mcg, 1 act QDS) Salbutamol Easyhaler DPI (100mg, 2 act QDS) Airomir inhaler MDI (100 mcg, 2 act QDS) Ventolin Evohaler MDI (100 mcg, 2 act QDS) Salbutamol inhaler CFC-free MDI (100 mcg, 2 act QDS) Jul 2015

15 3.2 Corticosteroids July 2015: Corticosteroids - cost of 1 year's treatment Fluticasone Evohaler (250 mcg, 2 act BD) Fluticasone Accuhaler (500 mcg, 1 act BD) Step 2 Very high dose mg BDP eq /day Fluticasone Evohaler (125 mcg, 2 act BD) Fluticasone Accuhaler (250 mcg, 1 act BD) Fluticasone Evohaler (250 mcg, 1 act BD) Budesonide 400 Turbohaler (1 act BD) Step 2 High dose mg BDP eq /day Easyhaler Budesonide (400mcg, 1 act BD) Qvar 100 Easi-Breathe (2 act BD) Clenil Modulite inhaler (250 mcg, 2 act BD) Mometasone Twisthaler (400 mcg 1 act) Budesonide inhaler (200 mcg, 1 act BD) Ciclesonide inhaler (160 mcg, 1 act) Fluticasone Accuhaler (100 mcg, 1 act BD) Budesonide 200 Turbohaler (1 act BD) Asmabec 100 Clickhaler (2 act BD) Fluticasone Evohaler (50 mcg, 2 act BD) Easyhaler Budesonide (200mcg, 1 act BD) Qvar 100 inhaler (1 act BD) Qvar 50 inhaler (2 act BD) Qvar 50 Easi-Breathe (2 act BD) Easyhaler Beclomethasone (200mcg, 1 act BD) Clenil Modulite inhaler (100 mcg, 2 act BD) Step 2 Standard dose - 0.4mg BDP eq /day 15 Jul 2015

16 3.2 Corticosteroid & bronchodilator inhalers July 2015: ICS/LABA combination inhalers - Cost of treatment for 1 year [Dotted Bars = licensed for COPD] Symbicort 400/12 Turbohaler (2 act BD) DPI DuoResp Spiromax 320/9 (2 act BD) Seretide 250 Evohaler (2 act BD) DPI MDI Flutiform 250/10 inhaler (2 act BD) Sirdupla 250 (2 act BD) Seretide 500 Accuhaler (1 act BD) Relvar Ellipta 184/22 inhaler (1 act OD) Symbicort 200/6 Turbohaler (2 act BD) Symbicort 400/12 Turbohaler (1 act BD) Seretide 250 Accuhaler (1 act BD) Seretide 125 Evohaler (2 act BD) DuoResp Spiromax 320/9 (1 act BD) DuoResp Spiromax 160/4.5 (2 act BD) Fostair 100/6 or NEXThaler (2 act BD) Flutiform 125/5 inhaler (2 act BD) Relvar Ellipta 92/22 inhaler (1 act OD) Sirdupla 125 (2 act BD) Symbicort 100/6 Turbohaler (2 act BD) Symbicort 200/6 Turbohaler (1 act BD) Seretide 50 Evohaler (2 act BD) Seretide 100 Accuhaler (1 act BD) DuoResp Spiromax 160/4.5 (1 act BD) Fostair 100/6 or NEXThaler (1 act BD) Flutiform 50/5 inhaler (2 act BD) DPI MDI MDI DPI DPI MDI MDI MDI DPI DPI DPI DPI DPI MDI DPI DPI MDI MDI DPI MDI DPI Low dose LABA - 12mcg formoterol Low dose LABA - 12mcg formoterol , mg/day BDP equivalent Very High Dose - Adult Step mg/day BDP equivalent High Dose - Adult Step mg/day BDP equivalent Standard Dose - Adult Step 3 16 Jul 2015

17 3.1 & 3.2 Inhaled therapy licensed for COPD Fluticasone/salmeterol [Seretide Accuhaler ] 500/25 DPI (1 act BD) Budesonide/formoterol [Symbicort Turbohaler ] 200/6 DPI (2 act BD) Budesonide/formoterol [Symbicort Turbohaler ] 400/12 DPI (1 act BD) Indacaterol/glycopyrronium [Ultibro Breezhaler] 85/43 DPI (1 act OD) Tiotropium [Spiriva Handihaler ] refill DPI (18 mcg, 1 act OD) Aclidinium/formoterol [Duaklir Genuair ] 340/12 DPI (1 act BD) Olodaterol/tiotropium [Spiolto Respimat ] SMI (2.5mcg/2.5mcg, 2 act OD) Umeclidinium/vilanterol [Anoro Ellipta ] 55/22 DPI (1 act OD) Budesonide/formoterol [DuoResp Spiromax] 160/4.5 DPI (2 act BD) Budesonide/formoterol [DuoResp Spiromax] 320/9 DPI (1 act BD) Beclometasone/formoterol [Fostair ] 100/6 MDI (2 act BD) Salmeterol [Serevent Evohaler ] MDI (25 mcg, 2 act BD) Indacaterol [Onbrez Breezhaler ] DPI (150 mcg, 1 act) Salmeterol [Serevent Accuhaler ] DPI (25 mcg, 2 act BD) Aclidinium [Eklira Genuair ] DPI (322 mcg, 1 act BD) Fluticasone furoate/vilanterol [Relvar Ellipta ] 92/22 DPI (1 act OD) Glycopyrronium [Seebri Breezhaler ] DPI (50mcg, 1 act OD) Umeclidinium [Incruse Ellipta ] DPI (65 mcg, 1 act OD) Olodaterol [Striverdi Respimat ] Soft Mist (2.5mcg, 2 act OD) Formoterol [Foradil ] inhalation powder DPI (12mcg, 1act BD) Formoterol modulite [Atimos ] MDI (12mcg, 1act BD) July 2015: Inhaled therapy licensed for COPD (ICS/LABA combinations, LABAs, LAMAs & LABA/LAMA combinations) - Cost of treatment for 1 year Formoterol Easyhaler DPI (12 mcg, 1 act BD) copyright 500 RDTC Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase type-4 inhibitors July 2015: Cromoglicate & related therapy, leukotriene receptor antagonists, and phosphodiesterase type 4 inhibitors - cost of 1 year's treatment Nedocromil inhaler (2mg, 2 act QDS) 1, Intal Fisonair inhaler (5mg, 2 act QDS) Roflumilast (500mcg OD) Zafirlukast (40mg) Intal Spincaps (20mg, 1 cap QDS) Montelukast (10mg) ,000 1, Jul 2015

18 3.4.1 Antihistamines July 2015: Antihistamines - cost of 1 year's treatment Alimemazine (10 mg BD) Acrivastine (8 mg TDS) Cyproheptadine (4 mg TDS) Ketotifen (1mg BD) Mizolastine MR (10 mg) Clemastine (2 mg) Levocetirizine (5 mg) Fexofenadine (120 mg) Chlorphenamine (4 mg TDS) Promethazine (25 mg) Desloratadine (5 mg) Hydroxyzine (25 mg) Loratadine (10 mg) Cetirizine (10 mg) Hypnotics & anxiolytics July 2015: Hypnotics and anxiolytics - cost of 14 days treatment Lormetazepam 1 mg Buspirone 10 mg (TDS) Clomethiazole capsules (2 ON) Clomethiazole syrup (10 ml ON) Loprazolam 1 mg 9.00 Melatonin MR 2 mg Chlordiazepoxide 10 mg (TDS) Temazepam 20 mg 5.32 Zaleplon 10 mg 3.76 Lorazepam 2.5 mg Oxazepam 15 mg (BD) Nitrazepam 5 mg Zopiclone 7.5 mg Zolpidem 10 mg Diazepam 10 mg Jul 2015

19 4.2 Atypical antipsychotics maintenance doses (adults with psychosis) July 2015: Atypical Antipsychotics maintenance doses (adults with psychosis) - cost of 1 year's treatment Paliperidone 12mg (9mg+3mg) OD 3, Aripiprazole 30mg OD 2, Quetiapine 600mg MR OD 2, Paliperidone 9mg OD 1, Paliperidone 6mg OD 1, Paliperidone 3mg OD 1, Lurasidone (Latuda ) 18.5mg 74mg OD 1, Aripiprazole 15mg OD Asenapine (Sycrest ) 10mg OD Asenapine (Sycrest ) 5mg OD N.B.: Asenapine is only intended for use in acute crisis and not licensed for maintenance therapy Risperidone 4mg (disp) OD Amisulpride 400mg BD Amisulpride 200mg BD Quetiapine 225mg (200mg+25mg) BD Olanzapine 20mg orodispersible OD Risperidone 6mg OD Quetiapine 150mg BD Olanzapine 5mg orodispersible OD Olanzapine 20mg OD Risperidone 4mg OD Olanzapine 5mg OD ,000 1,500 2,000 2,500 3,000 3, Jul 2015

20 4.2 Atypical antipsychotics Low doses July 2015: Atypical Antipsychotics Low Doses - cost of 1 year's treatment Risperidone 500microgram (orodispersible) BD Risperidone 1mg (orodispersible) BD Sulpiride 200mg BD Amisulpride 50mg tablets BD Risperidone 500microgram BD Risperidone 1mg BD Quetiapine 25mg BD Haloperidol 500micrograms Olanzapine 2.5mg tablets Quetiapine 25mg OD Jul 2015

21 4.3 Antidepressant drugs July 2015: Antidepressant drugs - cost of 1 year's treatment Trimipramine (75 mg) 1, Nortriptyline (75 mg) 1, Agomelatine (25mg) Duloxetine (60 mg) Phenelzine (60 mg) Venlafaxine (75 mg MR) Lofepramine (140 mg) Mianserin (30 mg) Reboxetine (8 mg) Trazodone (150 mg) Fluvoxamine (100 mg) Moclobemide (300 mg) Clomipramine (75 mg) Imipramine (75 mg) Amitriptyline (75 mg) Paroxetine (20 mg) Flupentixol (1 mg) Dosulepin (75 mg) Sertraline (50 mg) Mirtazapine (30 mg) Venlafaxine (75 mg) Escitalopram (10mg) Fluoxetine (20 mg) Citalopram (20 mg) ,000 1,200 1,400 1, Jul 2015

22 4.5 Drugs used in the treatment of obesity July 2015: Drugs used in the treatment of obesity - cost of 1 year's treatment Orlistat (120 mg TDS) Drugs used in nausea and vertigo July 2015: Drugs used in nausea and vertigo - cost of 1 year's treatment Prochlorperazine buccal tablets (3 mg BD) Hyoscine patch (Scopoderm TTS, once every 3 days) Hyoscine (20 mg TDS) Promethazine (Avomine, 25 mg BD) Cyclizine (50 mg BD) Cinnarizine (15 mg TDS) Promethazine (Phenergan 25 mg BD) Domperidone (10 mg TDS) Prochlorperazine (5 mg TDS) Metoclopramide (10 mg TDS) Betahistine (16 mg BD) Jul 2015

23 4.7 Analgesics July 2015: Analgesics - cost of 7 days treatment Tramacet effervescent (8 tablets) Aspirin 300 mg (12 tablets) Tramacet (8 tablets) Nefopam 30 mg (9 tablets) Tramadol MR 400 mg (1 tablet) Buprenorphine 400 micrograms (4 tablets) Remedeine (8 tablets) Co-codamol effervescent 30/500 (8 tablets) Co-codamol effervescent 8/500 (8 tablets) Co-codamol 30/500 (8 tablets) 3.77 Codeine 30 mg (8 tablets) Dihydrocodeine 30 mg (8 tablets) DHC Continus 120 mg (2 tablets) Co-codamol 30/500 (8 capsules) Tramadol 50 mg (8 capsules) Co-codamol 8/500 (8 tablets) Co-dydramol 10/500 (8 tablets) Paracetamol 500 mg (8 tablets) Jul 2015

24 4.7.2 Opioid analgesics July 2015: Opioid analgesics - cost of 7 days treatment Diconal (4 tablets) Pethidine 50 mg (8 tablets) Pentazocine 25 mg tablets (8 daily) Oxycodone 20mg / Naloxone 10mg MR tablets (4 daily) Oxycodone 40 mg MR tablets (2 daily) Oxycodone 20 mg capsules (4 daily) Pentazocine 50 mg capsules (4 daily) Tapentadol 150 mg MR tablets (2 daily) Tapentadol 75 mg tablets (4 daily) Hydromorphone 2.6 mg capsules (8 daily) Fentanyl transdermal patch (50 mcg per hour, 1 every 3 days) Hydromorphone 8 mg MR capsules (2 daily) Meptazinol 200 mg (8 tablets) Buprenorphine transdermal patch (10 mcg per hour, 1 per week) 7.89 Tramadol MR 400 mg (1 tablet) 7.13 Morphine 20 mg (5 tablets) 6.63 Morphine 10 mg / 5 ml oral solution (50 ml daily) 6.62 Morphine MR tablets (60 mg BD) 5.67 Buprenorphine 400 mcg sublingual (4 tablets) 5.64 Morphine MR capsules (60 mg BD) Jul 2015

25 4.7.2 MR Opioid analgesics July 2015: MR opioid analgesics - cost of 7 days treatment Oxeltra 40mg modified-release tablets (1 BD) OxyContin 40mg modified-release tablets (1 BD) Oxylan 40mg modified-release tablets (1 BD) Longtec 40mg modified-release tablets (1 BD) Reltebon 40mg modified-release tablets (1 BD) Oxeltra 20mg modified-release tablets (1 BD) OxyContin 20mg modified-release tablets (1 BD) Oxylan 20mg modified-release tablets (1 BD) Longtec 20mg modified-release tablets (1 BD) 8.75 Reltebon 20mg modified-release tablets (1 BD) 7.51 MXL 120mg capsules (1 OD) 7.29 MST Continus 60mg tablets (1 BD) 5.67 Morphgesic SR 60mg tablets (1 BD) 4.21 Zomorph 60mg modified-release capsules (1 BD) 3.78 Filnarine SR 60mg tablets (1 BD) 3.59 MXL 60mg capsules (1 OD) 3.74 MST Continus 30mg tablets (1 BD) 2.91 Morphgesic SR 30mg tablets (1 BD) Zomorph 30mg modified-release capsules (1 BD) Filnarine SR 30mg tablets (1 BD) Several NHS bodies recommend that modified-release forms of strong opioids be prescribed by brand name to avoid confusion and reduce risk of harm Jul 2015

26 4.7.2 Strong opioid analgesics equipotent dose cost per 24 hours July 2015: Costs per 24 hours for strong opioids administered via subcutaneous infusion Oxycodone 100mg/24hours Diamorphine 100mg/24hours 8.48 Morphine sulphate 150mg/24hours 4.42 Oxycodone 30mg/24hours Diamorphine 30mg/24hours Morphine 45mg/24hours Please Note: Doses shown are only approximately equivalent and for price comparison purposes only. Extreme caution is required when converting from one parenteral opioid to another and specialist advice should always be sought. Diamorphine 15mg/24hours Oxycodone 15mg/24hours Morphine 30mg/24hours Diamorphine 10mg/24hours There are differences in opinion regarding dose conversion ratios current practice is based on pharmacokinetic data from observational and uncontrolled studies, and on expert opinion and experience. Reported equi-analgesic dose ratios vary widely. When converting from one opioid to another, regular assessment and reassessment of efficacy and adverse effects is essential because of the lack of evidence on equi-analgesic doses and inter-individual variations. Oxycodone 10mg/24hours 1.60 Morphine 15mg/24hours 0.90 Diamorphine 5mg/24hours 2.27 Morphine 10mg/24hours 0.94 Oxycodone 5mg/24hours Jul 2015

27 4.7.3 Neuropathic pain July 2015: Neuropathic pain - cost of 1 year's treatment Pregabalin (100mg TDS) 1, Lidocaine patch (1/day) Pregabalin (150mg BD) Nortriptyline (25mg OD) Duloxetine (60mg OD) Carbamazepine (200mg QDS) Capsaicin 0.075% cream (1.5g/day) Gabapentin (600mg TDS) Gabapentin (2x300mg TDS) Amitriptyline (25mg OD) ,000 1,200 1,400. Individual responses and prescribed doses vary substantially in the management of neuropathic pain Antimigraine drugs (acute) July 2015: Antimigraine drugs (acute) - cost of 1 days treatment Sumatriptan injection (6 mg) Sumatriptan (Imigran Radis 100 mg) Sumatriptan nasal spray (20 mg) Rizatriptan wafers (10 mg) Eletriptan (20 or 40 mg) Almotriptan (12.5 mg) Frovatriptan (2.5 mg) Migril (4 tablets) Tolfenamic acid (200 mg) Rizatriptan tablets (10 mg) Naratriptan (2.5 mg) Sumatriptan tablets (100 mg) Sumatriptan tablets (50mg) Zolmitriptan (2.5 mg) Jul 2015

28 4.8 Antiepileptic drugs Perampanel 2mg tablets (OD) Lacosamide 150mg (BD) Eslicarbazepine 800mg Zonisamide 100mg capsules (QDS) Ethosuximide 250mg capsules (QDS) Pregabalin 150mg capsules (BD) Levetiracetam (Desitrend ) 750mg sachets (BD) Phenytoin sodium 100mg capsules (TD) Primidone 250mg tablets (BD) Vigabatrin 500mg tablets (QDS) Oxcarbazepine 450mg tablets Epilim Chrono tablets (1200mg daily) Episenta MR capsules (1200mg daily) Topiramate 200mg tablets (BD) Epival CR tablets (1200mg daily) Sodium valproate 200mg gastro-resistant tablets Levetiracetam 750mg tablets (BD) Clobazam 10mg tablets (BD) Clonazepam 2mg tablets (BD) Carbamazepine 400mg MR tablets (BD) Gabapentin 400mg capsules (TD) Phenobarbital 30mg tablets (TD) Lamotrigine 100mg tablets (BD) July 2015: Antiepileptic drugs - cost of 1 year's treatment , , , , Levetiracetam (Desitrend ) 750mg sachets (BD) = Levetiracetam (Desitrend ) 500mg sachets (BD) + Levetiracetam (Desitrend ) 250mg sachets (BD) 1, Oxcarbazepine 450mg tablets = Oxcarbazepine 300mg tablets (BD) + Oxcarbazepine 150mg (BD) tablets Modified-release sodium valproate: Epilim Chrono tablets 1200mg daily = Epilim Chrono 500mg tablets (BD) + Epilim Chrono 200mg tablet (OD) Episenta MR capsules 1200mg daily = 2 x Episenta 300mg MR capsules BD Epival CR tablets 1200mg daily = 2 x Epival 300mg CR tablets BD ,000 1,200 1,400 1,600 1,800 2, Jul 2015

29 Nicotine dependence July 2015: Nicotine dependence - cost of 7 days treatment Nicotine 2 mg sublingual tablets (40) Nicorette QuickMist (single pack) 1mg/spray (64 sprays) Nicorette nasal spray (64 sprays) Nicorette QuickMist (double pack) 1mg/spray (64 sprays) Nicotinell lozenge 1 mg (25 lozenges) Nicotinell chewing gum 2 mg (25 pieces) Niquitin lozenges 2 or 4 mg (15 lozenges) Niquitin gum 2 or 4 mg (15 pieces) Varenicline 1 mg (BD) Nicotinell chewing gum 4 mg (15 pieces) Nicorette chewing gum 4 mg (15 pieces) Nicorette patches 5, 10, or 15 mg (1 patch) Niquitin 7, 14, or 21 mg (1 patch) 9.97 Nicotinell TTS 30 (1 patch) 9.97 Bupropion 150 mg MR (BD) 9.74 Nicotinell TTS 20 (1 patch) 9.40 Nicotinell TTS 10 (1 patch) 9.12 Nicorette chewing gum 2 mg (15 pieces) Jul 2015

30 4.11 Drugs for dementia July 2015: Drugs for dementia - cost of 1 year's treatment Galantamine 24mg MR capsules Galantamine 12mg tablets Rivastigmine 4.6mg/24 hours patches Memantine hydrochloride 5 mg/actuation oral solution Galantamine 16mg MR capsules Galantamine 8mg tablets 1, Gatalin XL 24mg capsules Gatalin XL 16mg capsules Rivastigmine 6mg capsules Rivastigmine 9.5mg/24 hours patches Donepezil 10mg orodispersible tablets Donepezil 5mg orodispersible tablets Rivastigmine 3mg capsules Memantine 20mg tablets Donepezil 10mg tablets Donepezil 5mg tablets ,000 copyright RDTC 1, Jul 2015

31 5 Miscellaneous antimicrobial and anthelmintic drugs July 2015: Miscellaneous antimicrobial and anthelmintic drugs - cost of 5 days treatment Nitrofurantoin MR (200 mg) 6.79 Nitrofurantoin capsules (200 mg) 3.47 Trimethoprim (400 mg) 3.12 Co-trimoxazole 480 mg (4) 2.24 Azithromycin (500 mg, three doses only) 1.74 Erythromycin (1g) 1.30 Nitrofurantoin tablets (200 mg) 1.26 Clarithromycin (250 mg BD) 1.18 Metronidazole tablets (1.2 g) 1.09 Mebendazole (100 mg, single-dose only) Penicillins July 2015: Penicillins - cost of 5 days treatment Ampicillin (1 g) 7.63 Floxapen (1 g) 4.58 Magnapen (4 capsules) 4.00 Co-amoxiclav 250/125 (3 tablets) 3.64 Augmentin 375 (3 tablets) 3.59 Co-fluampicil 250/250 (4 capsules) 2.79 Amoxil (750 mg) 2.41 Amoxicillin (750 mg) 0.93 Flucloxacillin (1 g) 0.88 Phenoxymethylpenicillin / Penicillin V (1 g) Jul 2015

32 5.1.2 Cephalosporins July 2015: Cephalosporins - cost of 5 days treatment Cefuroxime (250 mg BD) Cefadroxil (500 mg BD) Cefixime (200 mg) 9.45 Cefaclor MR (375 mg BD) 6.50 Cefaclor (250 mg TDS) 4.86 Cefradine (500 mg BD) 1.75 Cefalexin capsules (500 mg BD) 0.84 Cefalexin tablets (500 mg BD) Tetracyclines July 2015: Tetracyclines - cost of 5 days treatment Demeclocycline (600 mg) Lymecycline (816 mg) 3.16 *Minocycline tablets (100 mg) 2.50 *Minocycline capsules (100 mg) 2.34 *Tetracycline (1 g) 1.87 *Minocycline MR (100 mg) 1.79 *Lymecycline (408 mg) 1.58 *Oxytetracycline (1 g) 0.81 *Doxycycline (100 mg) 0.67 *courses for acne will be longer than 5 days Jul 2015

33 Quinolones July 2015: Quinolones - cost of 5 days treatment Ofloxacin (800 mg) Moxifloxacin (400 mg) Levofloxacin (500 mg) 9.03 Ciprofloxacin (500 mg BD) 1.07 Ciprofloxacin (250 mg BD) Miscellaneous antifungal drugs (including topical and gynaecological) July 2015: Miscellaneous antifungal drugs (including topical and gynaecological) - cost of 28 days treatment unless otherwise stated Itraconazole (200 mg OD, 7 days) 4.32 Clotrimazole pessary (500 mg x 1) Ketoconazole 2% shampoo (120 ml) Miconazole oral gel (15 g, 1 tube) Terbinafine (250 mg OD, 28 days) Miconazole pessaries (100 mg x 14) Miconazole vaginal capsule (1.2 g x 1) Nystatin suspension (1 ml, QDS, 1 week) Miconazole 2% cream (30 g, 1 tube) 1.82 Clotrimazole 1% cream (20 g, 1 tube) Itraconazole (200 mg BD, 1 day) Fluconazole (150 mg, single-dose) Fluconazole (50 mg OD for 2 weeks) Jul 2015

34 6.1.1 Insulins (prefilled pens and cartridges) July 2015: Insulins (prefilled pens) - cost of 1 year's treatment Xultophy (40 units) Long-acting insulin+glp-1 1, combination Humalog Mix 25 KwikPen (40 units) Humalog Mix 50 KwikPen (40 units) NovoMix 30 FlexPen (40 units) Humulin M3 KwikPen (40 units) Mixed Insulins Insuman Comb 25 SoloStar (40 units) Tresiba FlexTouch (40 units) Levemir FlexPen (40 units) Lantus SoloStar (40 units) Intermediate and long acting insulins Humulin I KwikPen (40 units) Insulatard InnoLet (40 units) Insuman Basal SoloStar (40 units) NovoRapid FlexPen (40 units) Humalog KwikPen (40 units) Short acting insulins Apidra SoloStar (40 units) ,000 1,200 1,400 1,600 1,800 Mi July 2015: Insulins (cartridges) - cost of 1 year's treatment Humalog Mix 50 (40 units) Humalog Mix25 (40 units) NovoMix 30 (40 units) Humulin M3 (40 units) Mixed Insulins Insuman Comb 25 (40 units) Insuman Comb 50 (40 units) Tresiba (40 units) Levemir (40 units) Lantus (40 units) Insulatard (40 units) Intermediate and long acting insulins Humulin I (40 units) Insuman Basal (40 units) Humalog (40 units) NovoRapid (40 units) Apidra (40 units) Short acting insulins Insuman Rapid (40 units) Humulin S (40 units) Jul 2015

35 Needles For Pre-Filled And Reusable Insulin Pens R c N July 2015: Needles for Pre-filled and Reusable Insulin Pens - cost of 100 needles Registered trade names BD AutoShield Duo 5mm/30G NovoFine 6mm/31G NovoTwist 5mm/32G Mylife Clickfine 6mm/31G Mylife Clickfine 4mm/32G Unifine Pentips 5mm/31G Unifine Pentips 4mm/32G & 6mm/31G Comfort Point 4mm/31G, 5mm/31G & 6mm/31G BD Micro-Fine Ultra 4mm/32G & BD Micro-Fine+ 5mm/31G Unifine Pentips Plus 5mm/31G & 6mm/31G Insupen 5mm/31G & 6mm/31G NeedleBay Fine 4mm/32G & 5mm/31G TriCare 4mm/32G & 5mm/31G Microdot Droplet & Omnican Fine 4mm & 6mm GlucoRx FinePoint 4mm/31G, Ultra 4mm/32G, 5mm/31G & Mylife Penfine Classic 4mm/32G & 6mm/32G NovoFine Autocover 8mm/30G Mylife Clickfine AutoProtect 8mm/29G NovoFine 8mm/30G Mylife Clickfine 8mm/31G Unifine Pentips 8mm/31G Unifine Pentips Plus 8mm/31G BD Micro-Fine+ 8mm/31G Insupen 8mm/31G NeedleBay Fine 8mm/31G Comfort Point 8mm/31G TriCare 6mm/31G & 8mm/31G Microdot Droplet 8mm/31G Omnican Fine 8mm/31G GlucoRx FinePoint 8mm/31G Mylife Penfine Classic 8mm/31G NovoFine 12mm/28G Mylife Clickfine 10mm/29G & 12mm/29G Unifine Pentips 12mm/29G Insupen 12mm/29G Comfort Point 12mm/29G GlucoRx FinePoint 10mm/29G & 12mm/29G Omnican Fine 10mm/30G & 12mm/29G to 6 mm Pen Needles mm Pen Needles 12 mm Pen Needles Needles may not be interchangeable - consult product literature 35 Jul 2015

36 Blood lancets July 2015: Blood lancets - cost of 100 lancets Registered trade names Unistik 3 Comfort lancets 1.8mm/28gauge 6.17 Multiclix lancets 0.3mm/30gauge 4.82 FastClix lancets 0.3mm/30gauge 4.82 Softclix lancets 0.4mm/28gauge 3.93 OneTouch Comfort lancets 0.2mm/33gauge 3.82 OneTouch UltraSoft lancets 0.4mm/28gauge 3.81 Thin lancets 0.36mm/28gauge 3.78 Microlet lancets 0.5mm/28gauge 3.72 FreeStyle lancets 0.5mm/28gauge 3.67 TRUEplus lancets 0.32mm/30gauge 2.90 Vitrex Soft lancets 0.65mm/23gauge 2.85 Milward Steri-Let Lancets 0.66mm/23gauge 2.85 Unilet Eco lancets 0.375mm/28gauge 2.80 Mylife lancets multicolour 0.3mm/30gauge 2.75 GlucoRx lancets 0.31mm/30gauge 2.75 Mylife lancets 0.3mm/30gauge 2.75 Omnican Lance Soft 0.3mm/30gauge 2.73 Apollo twist lancets 0.36mm/28gauge icare Advanced lancets 0.38mm/30gauge Green bars denote lancets considered compatible with all marketed finger pricker devices Jul 2015

37 6.1.6 Blood glucose monitoring R Test M Registered trade names Compact July 2015: Blood glucose monitoring - cost of 50 tests Mobile Aviva Mobile test cassettes supplied in packs of 100 costing FreeStyle Lite FreeStyle Optium Contour OneTouch Verio Contour Next icare Advanced Solo OneTouch Ultra icare Advanced Solo testing strips has extended life span, see manufacturer guidelines GlucoRx Nexus 9.95 Active 9.95 TRUEyou 9.92 GlucoLab 9.89 GluNEO 9.89 Omnitest Element 9.89 WaveSense JAZZ 9.87 icare Advanced 9.70 Contour TS 9.50 Mylife Pura 9.50 Mylife Unio 9.50 SuperCheck Plus 9.45 GlucoRx Original AutoSense AutoSense testing strips supplied in packs of 25 costing 4.50 SuperCheck TEE2 SD Codefree Glucoflex-R Visually readable The test strips included in the chart are a mixture of the most commonly prescribed in the North of England, the least costly and those w ith extended shelf-lives Test strips are not usually interchangeable - consult manufacturers' literature 37 Jul 2015

38 6.1.2 Antidiabetic drugs July 2015: Antidiabetic drugs - cost of 1 year's treatment Liraglutide (1.8mg OD) Dulaglutide (0.75mg or 1.5mg per week) Exenatide (2mg per week) Liraglutide (1.2mg OD) Exenatide (5 or 10 mcg BD) Tolbutamide (1.5 g/day) Lixisenatide (20 mcg OD) Empagliflozin (10mg OD) Dapagliflozin (10 mg OD) Dapagliflozin (5mg) / metformin (850mg BD) Canagliflozin (50mg) / metformin (850mg BD) Canagliflozin (100mg OD) Pioglitazone (15mg) / metformin (850 mg BD) Linagliptin (2.5mg) / metformin (850mg BD) Metformin 1g / sitagliptin 50mg (BD) Sitagliptin (100 mg OD) Linagliptin (5 mg OD) Vildagliptin (50 mg BD) Vildagliptin (50mg)/ metformin (850mg BD) Saxagliptin (5mg OD) Saxagliptin (2.5mg) / metformin (850mg BD) Alogliptin (12.5mg) / metformin (1g BD) Alogliptin (25mg, 12.5mg, 6.25mg OD) Nateglinide (180 mg/day) Acarbose (150 mg/day) Metformin 500 mg MR (3/day) Glipizide (10 mg/day) Metformin (1.5 g/day) DOSE NOT RECOMMENDED BY NICE , , Repaglinide (4 mg) Gliclazide (160 mg/day) Glimepiride (2 mg OD) Pioglitazone (30 mg OD) Pioglitazone (15 mg OD) Needles are included in packs of long-acting exenatide (2mg per w eek) and dulaglutide (0.75mg or 1.5mg per w eek) at no extra cost. The cost of needles for other GLP-1 agonists w ill vary between 22 pa and 95 pa, depending on dose frequency and needle choice ,000 1, Jul 2015

39 6.1.2 Antidiabetic drugs Newer agents Liraglutide (1.8mg OD) Dulaglutide (0.75mg or 1.5mg per week) Exenatide (2mg per week) Liraglutide (1.2mg OD) Exenatide (5 or 10 mcg BD) Lixisenatide (20 mcg OD) Canagliflozin (300mg OD) Empagliflozin (10mg or 25mg OD) Dapagliflozin (5mg) / metformin (850mg BD) Dapagliflozin (5mg or 10 mg OD) Canagliflozin (100mg OD) Canagliflozin (50mg) / metformin (850mg BD) Metformin 1g / sitagliptin 50mg (BD) Linagliptin (5 mg OD) Sitagliptin (100 mg OD) Linagliptin (2.5mg) / metformin (850mg BD) Vildagliptin (50 mg BD) Vildagliptin (50mg)/ metformin (850mg BD) Saxagliptin (5mg OD) Saxagliptin (2.5mg) / metformin (850mg BD) Alogliptin (25mg, 12.5mg, 6.25mg OD) Alogliptin (12.5mg) / metformin (1g BD) July 2015: Antidiabetic drugs - Newer agents - cost of 1 year's treatment DOSE NOT RECOMMENDED BY NICE , , Needles are included in packs of long-acting exenatide (2mg per w eek) and dulaglutide (0.75mg or 1.5mg per w eek) at no extra cost. The cost of needles for other GLP-1 agonists w ill vary betw een 22 pa and 95 pa, depending on dose frequency and needle choice ,000 1,200 1,400 1, Bisphosphonates and other drugs affecting bone metabolism July 2015: Bisphosphonates and other drugs affecting bone metabolism - cost of 1 year's treatment Denosumab (Prolia ) Strontium ranelate sachets (2 g) Risedronate sodium (5 mg) Ibandronic acid (150 mg monthly) Alendronic acid (10 mg) Risedronate sodium (35 mg weekly) Alendronic acid (70 mg weekly) Jul 2015

40 7.3 Contraceptives Combined hormonal contraceptives July 2015: Contraceptives - Combined Hormonal Contraceptives - cost of 1 year's treatment Registered trade names Cilest (21) Lizinna (21) Synphase (21) TriNovum (21) BiNovum (21) Norimin (21) Brevinor (21) Ovysmen (21) Ethinylestradiol 35 microgram Elevin (21) Cleosensa (21) Yasmin (21) Dretine (28) Acondro (21) Marvelon (21) Femodene (21) Alenvona (21) Femodene ED (28) Katya 30/75 (21) Gedarel 30/150 (21) Millinette 30/75 (21) Lestramyl (21) Cimizt (21) Loestrin 30 (21) Microgynon 30 ED (28) Microgynon 30 (21) Ovranette (21) Rigevidon (21) Levest (21) Ethinylestradiol 30 microgram Femodette (21) Mercilon (21) Sunya (21) Millinette 20/75 (21) Gedarel 20/150 (21) Loestrin 20 (21) Ethinylestradiol 20 microgram Nuvaring (28) Qlaira (28) Zoely (28) Evra (21) Triadene (21) Logynon (21) Logynon ED (28) TriRegol (21) Norinyl-1 (21) Other contraceptives Jul 2015

41 7.3 Contraceptives Progestogen-only contraceptives July 2015: Contraceptives - Progestogen-only Contraceptives - cost of 1 year's treatment Registered trade names Cerazette (28) Desorex (28) Aizea (28) Cerelle (28) Nacrez (28) Zelleta (28) Norgeston (28) Oral Progestogen-only Contraceptives Noriday (28) 9.10 Micronor (28) 7.80 Sayana Press (1 every 13 wks) Nexplanon (1 every 3 yrs) Noristerat (1 every 8 wks) Depo-Provera pfs (1 every 12 wks) Jaydess (1 every 3 yrs) Parenteral and Intra-uterine Progestogen-only Contraceptives Mirena (1 every 5yrs) Jul 2015

42 7.4.1 Drugs for urinary retention July 2015: Drugs for urinary retention - cost of 1 year's treatment Solifenacin 6mg / Tamsulosin 400microgram modified-release tablets Dutasteride 500microgram / Tamsulosin 400microgram capsules Dutasteride (500 micrograms) Alfuzosin MR (10 mg) Tamsulosin MR tablets (400 micrograms) Indoramin (40 mg) Prazosin (4 mg) Alfuzosin (7.5 mg) Tamsulosin MR capsules (400 micrograms) Terazosin (5 mg) Finasteride (5 mg) Doxazosin (4 mg) Jul 2015

43 7.4.2 Drugs for urinary frequency, enuresis and incontinence July 2015: Drugs for urinary frequency, enuresis and incontinence - cost of 1 year's treatment Duloxetine (40 mg BD) Solifenacin (10 mg) Oxybutynin patch (Kentera ) Mirabegron MR (Betmiga 25mg/50mg OD) Propiverine (15 mg TDS) Propantheline 15 mg tablets (5) Fesoterodine MR (4 or 8 mg OD) Tolterodine MR (4 mg) Solifenacin (5 mg) Oxybutynin MR (10 mg) Darifenacin (7.5 or 15 mg OD) Propiverine MR (30mg) Trospium (20 mg BD) Trospium MR (Regurin XL 60mg) Oxybutynin (3 mg BD) Trospium (Flotros 20 mg BD) Oxybutynin MR (5 mg) Flavoxate (200 mg TDS) Tolterodine (2 mg BD) Oxybutynin (5 mg BD) Oxybutynin (2.5 mg BD) Jul 2015

44 7.4.5 Drugs for erectile dysfunction July 2015: Drugs for erectile dysfunction - cost of 1 year's treatment Tadalafil 5mg Alprostadil MUSE 250mcg Alprostadil 3mg/g (Vitaros ) Alprostadil (Caverject vials) 10microgram Alprostadil (Viridal duo) 10microgram Alprostadil (Caverject Dual Chamber) 10microgram Tadalafil 10mg Tadalafil 20mg Vardenafil 20mg Avanafil 200mg N.B.: Costs, other than for tadalafil 5mg, based on advice from DH (circulated in HSC 1999/148) that one treatment per week will be sufficient for most patients treated for erectile dysfunction. Tadalafil 5mg cost assumes daily dose. Vardenafil 10mg Avanafil 100mg Sildenafil 100mg Sildenafil 50mg Calcium and vitamin D July 2015: Calcium + vitamin D & vitamin D preparations - cost of 1 year's treatment Calcium and ergocalciferol, 2 chewable tablets (194 mg calcium, 800 units vitamin D) Cacit D3, 2 sachets dissolved in water (1 g calcium, 880 units vitamin D) Calcichew D3, 2 chewable tablets (1 g calcium, 400 units vitamin D) Calcichew D3, 2 caplets swallowed whole or chewable (1 g calcium, 800 units vitamin D) Calfovit D3, 1 sachet dissolved in water (1.2 g calcium, 800 units vitamin D) Calcichew D3 Forte, 2 chewable tablets (1 g calcium, 800 units vitamin D) Adcal D3, 4 caplets swallowed whole (1.2g calcium, 800 units vitamin D) Adcal D3, 2 chewable tablets (1.2 g calcium, 800 units vitamin D) Natecal D3, 2 chewable tablets (1.2 g calcium, 800 units vitamin D) Fultium D3, 1 capsule swallowed whole (800 units vitamin D) Desunin, 1 tablets swallowed whole (800 units vitamin D) Calceos, 2 chewable tablets (1 g calcium, 800 units vitamin D) Evacal, 2 chewable tablets (1.2 g calcium, 800 units vitamin D) Accrete D3, 2 tablets swallowed whole (1.2g calcium, 800 units vitamin D) Jul 2015

45 Non-steroidal anti-inflammatory drugs July 2015: Non-steroidal anti-inflammatory drugs - cost of 1 year's treatment Aspirin 300 mg tablets (12) Etoricoxib (90 mg) Acemetacin (60 mg BD) Tenoxicam (20 mg) Tiaprofenic acid MR (300 mg BD) Etodolac MR (600 mg) Ketoprofen (50 mg TDS) Aceclofenac (100 mg BD) Nabumetone (1 g) Flurbiprofen MR (200 mg) Naprosyn / Naprosyn EC (250 mg TDS) Naproxen EC (250 mg TDS) Mefenamic acid (500 mg) Piroxicam (20 mg) Ibuprofen (400 mg TDS) Naproxen (250 mg TDS) Indometacin (50 mg BD) Diclofenac sodium (50 mg TDS) Celecoxib (200 mg) Meloxicam (7.5 mg) Jul 2015

46 Rubefacients, topical NSAIDs, capsaicin, and poultices July 2015: Rubefacients, topical NSAIDs, capsaicin, and poultices - cost of 1 year's treatment Felbinac 3% gel (3 g) Benzydamine 3% cream (Difflam, 3g) Piroxicam 0.5% gel (3 g) Diclofenac 1% gel (3 g) Ibuprofen 10% gel (Ibugel Forte, 3g) Ibuprofen 5% gel (3 g) Ketoprofen 2.5% gel (3 g) Rubefacient (e.g. Transvasin cream, 3 g) Jul 2015

47 11.6 Treatment of Glaucoma July 2015: Treatment of Glaucoma - cost of 1 year's treatment Dorzolamide 2% + timolol 0.5% (Cosopt ) PF Dorzolamide 2% (Trusopt ) PF Tafluprost + Timolol (Taptiqom ) PF Bimatoprost 0.03% (Lumigan ) PF Tafluprost (Saflutan ) PF Timolol 0.5% (Timoptol ) PF Latanoprost (Monopost ) PF Timolol 0.25% (Timoptol ) PF Timolol gel (Tiopex ) PF Travoprost + timolol (Duotrav ) Preservative free preparations Latanoprost (Xalatan ) Bimatoprost + timolol (Ganfort ) Travoprost (Travatan ) Bimatoprost 0.01% (Lumigan ) Brinzolamide + timolol (Azarga ) Bimatoprost 0.03% Brimonidine + timolol (Combigan ) Brinzolamide 1% + Brimonidine 0.2% (Simbrinza ) Carteolol 2% (Teoptic ) Carteolol 1% (Teoptic ) Brinzolamide (Azopt ) Pilocarpine 4% Pilocarpine 2% Latanoprost + timolol Timolol 0.25% LA (Timoptol -LA) Timolol 0.5% LA (Timoptol -LA) Pilocarpine 1% Dorzolamide 2% + timolol 0.5% Dorzolamide 2% Brimonidine 0.2% Latanoprost (generic) Betaxolol 0.5% (Betoptic ) Levobunolol 0.5% Timolol 0.25% Timolol 0.5% Jul 2015

48 Tear Deficiency, Ocular Lubricants, and Astringents July 2015: Tear deficiency, ocular lubricants, and astringents - cost of 1 year's treatment Sodium hyaluronate 0.15% PF (Hyabak) 10ml Carmellose, glycerol and castor-oil (Optive Plus) 10ml Carmellose and glycerol (Optive) 10ml Sodium hyaluronate 0.20% PF (Hyloforte) 10ml Sodium hyaluronate 0.15% (Oxyal) 10ml Liquid paraffin (Lacrilube ointment) 5g Hypromellose 0.3% PF (Tear-Lac) 10ml Sodium hyaluronate 0.03% PF (Hylofresh) 10ml Carbomer % (Geltears) 10g Hypromellose 0.3% (Generic) 10ml Polyvinyl alcohol (Sno Tears) 10ml Liquid paraffin + retinol (VitA-POS ointment) 5g Assumptions & Calculations 200 drops/applications per pack for non-metered-dose products 1 drop/application per eye to both eyes TDS for 365 days for drops. 1 application at night for ointments. Rounded up to nearest full pack co Nasal steroids July 2015: Nasal steroids - cost of 28 days treatment Fluticasone 50 mcg/azelastine 137 mcg (Dymista ) 1 spray both nostrils bd Fluticasone proprionate 50mcg (Flixonase ) 1 spray both nostrils od 4.11 Triamcinolone 55 mcg (Nasacort ) 1 spray both nostrils od 3.45 Mometasone 50 mcg (Nasonex ) 1 spray both nostrils od 3.07 Fluticasone furoate 27.5 mcg (Avamys ) 1 spray both nostrils od 3.01 Fluticasone proprionate 50mcg (Nasofan ) 1 spray both nostrils od 3.00 Budesonide 64 mcg (Rhinocort aqua ) 1 spray both nostrils od 1.63 Beclometasone 50 mcg (200 dose) 1 spray both nostrils bd Jul 2015

49 Emollients (by volume) July 2015: Emollients by volume - cost of 1 year's treatment Calmurid (500g) Balneum plus (500g) E45 Itch relief (500g) Aveeno Cream (300ml) Yellow Soft Paraffin (500g) , Preparations containing urea Aveeno Lotion (500ml) Dermol Cream (500g) Thirty:30 Ointment (500g) Diprobase Cream (500g) Dermol Lotion (500ml) Diprobase Ointment (500g) Cetraben (500g) Doublebase Gel (500g) E45 Cream Zerobase cream (500g) Oilatum Cream (500ml) Aqueous Cream (500g) Hydrous Ointment (500g) Ultrabase (500g) LP/WSP Ointment (50:50) (500g) E45 Lotion (500ml) ZeroCream (500g) Fifty:50 Ointment (500g) ZeroAQS emollient cream (500g) White Soft Paraffin (500g) Epimax cream (500g) Emulsifying Ointment (500g) Oilatum Junior cream (500ml) Volumes can vary between products. Usage is based on 600g/ml per adult and for Oliatum Junior cream 250ml per week ,000 1,500 2,000 2, Jul 2015

50 Emollients per 100g/ml July 2015: Emollients per 100g/ml Calmurid (500g) Balneum plus (500g) E45 Itch relief (500g) Preparations containing urea Aveeno Cream (300ml) Yellow Soft Paraffin (500g) Aveeno Lotion (500ml) Dermol Cream (500g) Thirty:30 Ointment (500g) Diprobase Cream (500g) Dermol Lotion (500ml) Diprobase Ointment (500g) Cetraben (500g) Doublebase Gel (500g) E45 Cream Zerobase cream (500g) Oilatum Cream (500ml) Oilatum Junior cream (500ml) Aqueous Cream (500g) Hydrous Ointment (500g) Ultrabase (500g) LP/WSP Ointment (50:50) (500g) E45 Lotion (500ml) ZeroCream (500g) Fifty:50 Ointment (500g) ZeroAQS emollient cream (500g) White Soft Paraffin (500g) Epimax cream (500g) Emulsifying Ointment (500g) Jul 2015

51 Emollient bath and shower preparations per 100g/ml July 2015: Emollient bath and shower preparations per 100g/ml Oilatum gel (150g) 3.43 Oilatum shower gel fragrance free (150g) 3.43 Doublebase emollient shower gel (200g) 2.61 Aveeno Bath Oil (250ml) 1.80 Dermol shower emollient (200ml) 1.78 Oilatum Bath Formula (500ml) 1.70 Oilatum Plus bath additive (500ml) 1.40 Balneum Plus bath oil (500ml) 1.33 E45 emollient wash cream (250ml) 1.28 Dermol Bath Emollient (600ml) 1.26 Dermol Lotion (500ml) 1.21 Doublebase Gel (500g) 1.17 Cetraben emollient bath additive (500ml) 1.15 Doublebase emollient bath additive (500ml) 1.09 Balneum Bath Oil (500ml) 1.08 E45 emollient bath oil (500ml) 1.02 Aqueous Cream (500g) 0.99 Oilatum Junior bath additive (600ml) 0.98 Zerolatum Emollient bath additive (500ml) 0.96 Oilatum Emollient (500ml) 0.91 Hydromol Bath & Shower emollient (500ml) 0.88 LPL 63.4 (500ml) Jul 2015