Thiamethoxam is a nicotinoid compound with broad-spectrum insecticidal properties.

Transcription

1 Thiamethoxam 8 THIAMETHOXAM (245) The first draft was prepared by Mr. Denis Hamilton Primary Industries and Fisheries Australia EXPLAATIO Thiamethoxam is a nicotinoid compound with broad-spectrum insecticidal properties. It is registered for use on numerous crops in many countries against sucking and chewing insects in vegetables, ornamentals, field crops, deciduous fruits, citrus, cotton and rice. It possesses contact and stomach activity. Its systemic properties has resulted in its use against foliar feeding insects via seed treatment, soil application, through irrigation systems, or applied to the trunks of trees. It is also registered for direct foliar application. The compound was evaluated as a new compound by the 2 JMPR for both residues and toxicology. The Meeting received information on physical and chemical properties, animal and plant metabolism, environmental fate, analytical methods, storage stability, use patterns, processing, farm animal feedingand supervised residue trials. IDETITY Thiamethoxam is a nicotinoid compound with broad-spectrum insecticidal properties. ISO common name thiamethoxam Chemical name IUPAC CAS (EZ)--(2-chloro-,-thiazol-5-ylmethyl)-5-methyl-,,5- oxadiazinan-4-ylidene(nitro)amine -[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl--nitro-4H-,,5-oxadiazin-4-imine CAS umber CIPAC umber 6 Synonyms for active substance: Molecular formula CGA 294 C 8 H Cl 5 O S Molecular mass 29. O Structural formula Cl S O 2 Thiamethoxam isomers Thiamethoxam is described as an EZ mixture. It is generally believed that the activation energy for the E Z interconversion for the C = bond is low and that an equilibrium mixture is rapidly established at ambient temperature. Cl S CGA 224 H CH H O O

2 88 Thiamethoxam The situation is similar for metabolite CGA 224. In this case the E form is likely to be favoured in the equilibrium mixture because of possible formation of a hydrogen bond from the secondary amine to the nitro group. The E form of CGA 224 is equivalent to the compound clothianidin. PHYSICAL AD CHEMICAL PROPERTIES Pure active ingredient: Thiamethoxam Property Result Ref Description (purity 99.%) Slightly cream, fine crystalline powder, odourless 5446 Melting point, melting range (purity 99.%) 9. C Pa at 2 C Vapour pressure (purity 99.%), OECD 6.6 Pa at 25 C. Measurements at 9.5 to 2 C 5445 Water solubility (purity 99.%) at 25 C, 4. g/l (pure water, no buffer, measured ph of aqueous phase OECD 5.) 5444 Octanol/water partition coefficient log P ow =. (pure water, no buffer, measured ph of aqueous 66 (purity 99.%) at 25 C, OECD phase 6.9) Hydrolysis rate (purity 99.%) [ C- oxadiazin label] ph 9, 25 C: days test; T.5 = 8.8 days ABR-9 Hydrolysis rate (purity 99.%) [ C- thiazol label] Photolysis rate, xenon arc at 4 w/m 2 for 2 hours/day, 25 C, mg/l in ph 5 buffer (purity > 99.9%) [ C-thiazol label] Dissociation constant in water (purity 99.%), OECD 2 ph, 6 C: 96% remained after 5 days test ph 5, 6 C: 99% remained after 5 days test ph, 6 C: 5 days test; T.5 = 8 days T.5 =. days ABR-966 ABR-989 no dissociation within ph range 2 to 2 82 The hydrolysis of CGA 224, an important metabolite and hydrolysis product of thiamethoxam was investigated by Ulbrich (999, 98UL). CGA 224 Hydrolysis rate (radiochemical purity 98.%) [ C-thiazol label]. Starting concentration: 5 mg/l. ph 4.2, sterile, dark, 2 C: no decline after days test ph 5., sterile, dark, 2 C: no decline after days test ph., sterile, dark, 2 C: no decline after days test ph 8.9, sterile, dark, 2 C: no decline after days test. 98UL Technical material: Thiamethoxam Property Result Ref Description (purity 98.2%) Off-white, fine powder, odourless 582 Acetone 48 g/l; dichloromethane g/l; Solubility in organic solvents (purity ethyl acetate. g/l; hexane < mg/l; methanol g/l; 98.2%) at 25 C octanol 62 mg/l; toluene 68 mg/l 5822 Hydrolysis rate (purity 98.%) [ C- oxadiazin label] Hydrolysis rate (purity 95.4%) [ C- oxadiazin label] Hydrolysis rate (purity 9.5%) [ C- thiazol label] Hydrolysis rate (purity 9.%) [ C- thiazol label] Hydrolysis rate (purity 98.4%) [ C- thiazol label] ph, 6 C: 96% remained after 5 days test ph 5, 6 C: % remained after 5 days test ph, 25 C: 96% remained after days test ph 9, 4 C: 96 hours test, T.5 = hours ph, 4 C: 8% remained after days test ph, 6 C: 2 days test; T.5 = days ph 5, 25 C: % remained after days test ph 9, 25 C: days test; T.5 = hours ph, 6 C: days test; T.5 = 2 days ph 9, 4 C: days test; T.5 = 26 hours ph 9, 6 C: days test; T.5 =.2 hours ph, 25 C: 98% remained after days test ph, 4 C: days test; T.5 = days ABR-9 ABR-9 ABR-966 ABR-966 ABR-966

3 Thiamethoxam 89 Property Result Ref Photolysis rate, xenon arc at 4 w/m 2 for 2 hours/day, 25 C, mg/l in ph 5 buffer (purity 9.%) [ C-oxadiazin label] T.5 = 2. days ABR-92 Cl S H H Cl S O Cl S O CGA 224 CGA 559 O 2 Thiamethoxam O 2 O Cl S H 2 Cl S H HO Cl S H O CGA 95 O 2 OA 446 H O 2 Figure Products of thiamethoxam hydrolysis were identified by Lowery (99, ABR-9) and Clark (998, ABR-966). CGA 95, CGA 559 and OA 446 were the major products of hydrolysis. CGA 224 was a minor product. H OH H H H H O Cl S O O O O O H CGA 542 OA 445 H Cl S H H Cl S O Cl S O CGA 224 O 2 Thiamethoxam O 2 CGA 559 O O H H 2 Cl S H H + COS + O C H isocyanic acid methylurea CGA 5968 O Figure 2 Products of thiamethoxam photolysis were identified by Sparrow (99, ABR-92) and Schwartz (998, ABR-989). FORMULATIOS The main formulation types are: Code Description Examples FS flowable concentrate for seed treatment 5 g/l, 6 g/l FS flowable concentrate for seed treatment (includes mefenoxam and fludioxonil) 258 g/l, 6 g/l

4 9 Thiamethoxam Code Description Examples GR granule (includes pyroquilon) 8 g/kg SC suspension concentrate 24 g/l SC suspension concentrate (includes azoxystrobin) 65 g/l SG water soluble granule 5 g/kg SL soluble concentrate 24 g/l WG water dispersible granule g/kg, 25 g/kg, g/kg, 4 g/kg ZC a mixed formulation of CS and SC (includes lambda-cyhalothrin) g/l A number of products are registered that contain thiamethoxam and another active ingredient, viz., azoxystrobin, fludioxonil, pyroquilon, lambda-cyhalothrin, lufenuron and cyproconazole. METABOLISM AD EVIROMETAL FATE Metabolism and environmental fate studies used thiamethoxam C labelled in the guanidine position or in position-2 the thiazole ring. Cl S O * O 2 [ C-oxadiazin-4]thiamethoxam = [ C-guanidine]thiamethoxam O Cl * S O 2 [ C-thiazol]thiamethoxam Structures, names and codes for metabolites are summarised below. Five possibilities for describing each metabolite are: a simple name, which could be a common name, a simplified systematic name, an abbreviation or a pseudo-common name (e.g. hydroxy-cypermethrin) the systematic chemical name it may be too cumbersome for use in discussion and tables the CAS number CAS numbers are not available for many metabolites the company code number, e.g. CGA 224 serial numbers, e.g., metab, metab 2, etc. In this evaluation, metabolites are described by the company code number where available or a metabolite serial number used in the metabolite studies. It should be noted that metabolite serial numbers are not necessarily consistent between studies, e.g. metabolites 4U, 8U and U are the same compound. -methyl--nitroguanidine Systematic: -nitro-'-methylguanidine CAS number: Code: OA 452 Code: MG (clothianidin evaluation) -methylguanidine Systematic: -methylguanidine Code: CGA 829 Code: MG (clothianidin evaluation) H H O 2 H H H 2

5 Thiamethoxam 9 CGA 265 Systematic: -(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine CAS number: Code: CGA 265 Code: TZG (clothianidin evaluation) CGA 29 Systematic:,6-dihydro--methyl--nitro-2H-,,5-oxadiazin-4-amine CAS number: Code: CGA 29 CGA 95: Systematic: (2-chlorothiazol-5-yl)-methylamine CAS number: Code: CGA 95 CGA 224 Systematic: -(2-chlorothiazol-5-ylmethyl)-'-methyl-"-nitroguanidine CAS number: Code: CGA 224 ote CGA 224-O-glucoside Hydroxylamine glucoside of CGA 224 CGA 455 Systematic:,6-dihydro--nitro-2H-,,5-oxadiazin-4-amine CAS number: Code: CGA 455 CGA 49 Systematic: 2-chloro-5-thiazolemethanol CAS number: Code: CGA 49 CGA 542 Systematic:,6-dihydro--methyl-2H-,,5-oxadiazin-4-amine Code: CGA 542 CGA 5968 Systematic: -(2-chlorothiazol-5-ylmethyl)--methylurea Code: CGA 5968 Code: TZMU (clothianidin evaluation) CGA 559 Systematic: -(2-chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4- one Code: CGA 559 CGA 5968 Systematic: 2-chlorothiazole-5-carboxylic acid CAS number: Code: CGA 5968 Code: CTCA (clothianidin evaluation) Cl H H S O 2 H O H O2 Cl S H 2 Cl H H S O 2 OH HO CH 2 OH O OH O Cl H S O 2 O H H O2 Cl S CH 2 OH H H O Cl H H S O O Cl S O Cl S COOH ote that clothianidin is the E isomer of CGA 224 ([C(E)]--[(2-chloro-5-thiazolyl)methyl]-'-methyl-"-nitroguanidine), CAS number (formerly ) (Wood, 2).

6 92 Thiamethoxam Component D O O H H Component K HO O O H H guanidine carbonate Code: OA Metab 6 Systematic: 2-acetylamino--[5-('-methyl-"-nitroguanidinomethyl)- thiazol-2-ylsulfanyl]-propionic acid Metab U Systematic: 2-acetylamino--[5-(5-methyl-4-oxo-[,,5]oxadiazinan-- ylmethyl)-thiazol-2-ylsulfanyl]-propionic acid Metab 4U, 8U, U Systematic: (2-chlorothiazol-5-ylmethyl)-urea Code: TZU (clothianidin evaluation) + H 2 H 2 H 2 H H O 2 O O Cl S 2- CO 2 S S COOH H O S S COOH H O H H 2 O Metab 5U Systematic: 2-acetylamino--(2-chlorothiazol-5-ylmethanesulfinyl)- propionic acid Cl S O S H O COOH Metab 6U Systematic: 2-acetylamino--(2-chlorothiazol-5-ylmethanesulfanyl)- propionic acid Metab L Systematic: 2-oxopropionic acid [-(2-chloro-thiazol-5-ylmethyl)-5- methyl-[,,5]oxadiazinan-4-ylidene]-hydrazide Cl Cl S S S O H H O COOH O O Methylurea O MU2 Systematic: 2-oxopropionic acid ([(2-chlorothiazol-5-ylmethyl)-amino]- methylamino-methylene)-hydrazide Code: ATMG-Pyr or PTMG (clothianidin evaluation) H Cl S H 2 H H H O O MU Systematic: amino-([(2-chlorothiazol-5-ylmethyl)-amino]-methylene)- hydrazide Code: ATG-Ac (clothianidin evaluation) Cl S H H 2 H O

7 Thiamethoxam 9 -nitroguanidine Systematic: -nitroguanidine Code: OA Code: TG or G (clothianidin evaluation) OA Systematic: 2-methylsulfanylthiazole-5-carboxylic acid Code: OA Code: MTCA (clothianidin evaluation) OA 446 Systematic: -(2-chloro-thiazol-5-ylmethyl)--nitrourea Code: OA-446 Code: CTU (clothianidin evaluation) OA 445 Systematic: -(2-chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4- ylidineamine Code: OA 445 OA 4225: Systematic: -(2-chlorothiazol-5-ylmethyl)-'-methyl-guanidine Code: OA 4225 Code: TMG (clothianidin evaluation) OA 4226 Systematic: -(2-chlorothiazol-5-ylmethyl)-guanidine Code: OA 4226 Code: TZG (clothianidin evaluation) OA Carbonic acid, compound with guanidine H + 2 CAS number: H 2 H 2 H 2 Cl Cl Cl Cl S S S S S O 2 H 2 S COOH H OH O 2 O H H H H H H 2 H 2- CO 2 Animal metabolism The Meeting received animal metabolism studies with thiamethoxam in laboratory animals, lactating goats and laying hens. Laboratory animals When rats were orally dosed with [ C-thiazol]thiamethoxam and [ C-oxadiazin]thiamethoxam at mg/kg bw (single high dose) or.5 mg/kg bw (single low dose), most of the dose was excreted in the urine (94%) and faeces (4%) within 24 hours (Müller and Stampf, 996, 2AM). The components of the excreted C label were identified by Thanei (998, 2AM2). Approximately 8% of the dose was eliminated in the urine as unchanged thiamethoxam. Metabolites CGA 224 and CGA 265 accounted for approximately % and % of the dose respectively, with all other metabolites below % of the dose. Identified metabolites are shown in Figure. Cl S H H O 2 Cl S H H O 2 H Cl S H O H Cl S H O H 2 CGA-224 CGA 265 CGA 5968 Metab4U

8 94 Thiamethoxam Cl S O S H O COOH Cl S S H O COOH S S COOH Cl S H OH O 2 Metab5U Metab6U OA OA 446 H H O 2 S S COOH H O O O S S COOH H O Cl S O O O H O2 Metab6U MetabU CGA 559 CGA 29 H O H H H O O2 CGA 542 CGA 455 Figure Identified thiamethoxam metabolites from orally dosed rats (Müller and Stampf, 996, 2AM and Thanei, 998, 2AM2). Lactating goats In a lactating goat metabolism study, two goats were dosed with [ C-thiazol]thiamethoxam via gelatin capsules for 4 consecutive days at 4. and.6 mg/kg bw/day, the equivalent of ppm thiamethoxam in the feed (Rümbeli, 998, 2AM). Milk was collected twice daily. Animals were slaughtered 6 hours after the final dose for tissue collection. Body weights were 42 and 48 kg and daily feed consumption was. kg (6 g concentrate + kg maize cubes + 2 g hay). Accountability of the administered C was 8% and 8% for the two goats, with most (55% and 6%) of the C excreted in the urine and faeces. Milk accounted for approximately % of the C and tissues approximately.4%. C residue levels in milk reached a plateau within.5 days. In a second lactating goat metabolism study, two goats were dosed with [ C- oxadiazin]thiamethoxam via gelatin capsule for 4 consecutive days at.9 and 4.5 mg/kg bw/day, the equivalent of 2 ppm thiamethoxam in the feed (Lutringer, 998, 2AM5). Milk was collected twice daily. Animals were slaughtered 6 hours after the final dose for tissue collection. Body weights were 42 and 48 kg and daily feed consumption was. kg (5 g concentrate + kg maize cubes + 2 g hay). Accountability of the administered C was 9% and 8% for the two goats, with most (5% and 54%) of the C excreted in the urine and faeces. Milk accounted for approximately % of the C and tissues approximately.%. C residue levels in milk reached a plateau within 2 days. The distribution and identity of the residues in tissues and milk of goats from the two studies are summarised in Table. Parent thiamethoxam was the major component of the residue in muscle, fat and kidney. CGA 224 was the major component in milk. In the liver, OA 4226 was the major component for the thiazol label and L for the oxadiazin label. Table Distribution and identity of the residues in tissues and milk of lactating goats dosed with [ C- thiazol]thiamethoxam and [ C-oxadiazin]thiamethoxam via gelatin capsule for 4 consecutive days Residues expressed as thiamethoxam, as mg/kg or % TRR Muscle Fat Liver Liver a Kidney Kidney a Milk [ C-thiazol]thiamethoxam TRR 2.8 mg/kg.9 mg/kg. mg/kg. mg/kg 6.6 mg/kg 6.6 mg/kg. mg/kg on-extracted 5.% 6.6% 5%.% 8.8%.2%.9%

9 Thiamethoxam 95 Residues expressed as thiamethoxam, as mg/kg or % TRR Muscle Fat Liver Liver a Kidney Kidney a Milk Thiamethoxam. mg/kg. mg/kg. mg/kg. mg/kg. mg/kg.4 mg/kg.6 mg/kg Thiamethoxam 5% b 6% b.%.% 2% 2% b % CGA % 2%.6%.2% 2.% 2.% 44% b OA % 2% 2% 22% b % % OA % % % % 8% 2% 8U 2.9% 2.%.4%.4%.4%.4% 2.8% CGA 265.%.% 2.2%.8%.2%.9% 8% CGA 95 2.% 2.% CGA 5968.%.%.9%.9% CGA % 2.6% 2.% 2.% CGA %.6%.5%.5% L % % 9.8% 9.8% MU2 6.6% 4.6% 5.9% 5.9% 9.% 9.2% OA 446.2%.2% 4.% 4.% OA 445.5% % % 2.4% 2.4% [ C-oxadiazin]thiamethoxam TRR 2.2 mg/kg.54 mg/kg. mg/kg. mg/kg.5 mg/kg.5 mg/kg.48 mg/kg on-extracted 6.% 8.% % % 8.9% 2.9%.9% Thiamethoxam.22 mg/kg. mg/kg.2 mg/kg.68 mg/kg.68 mg/kg.54 mg/kg Thiamethoxam 54% b 52% b.% 22% 22% b % CGA %.6% 6.4% 45% b L 5.6% 2% 25% b 8.5% 8.9% 8U.2%.%.%.%.%.%.% CGA %.6%.6% 2.2% % CGA 559.%.% 2.5% 2.5% MU2 % 5.% 5.%.5%.8% 5.6%.6% 2% 2% OA 446.2% -methyl--.4%.%.5%.5%.6%.6% 2.8% nitroguanidine OA 445.5% 9.2% 9.2% 5.% 5.% OA % % 9.% % 6% 6% OA % % 4.9% 8.% 4.8% 6.% a microwave assisted extraction. b major component of the residue Cl S O O 2 Cl S H H O 2 Cl S H H H 2 Cl S H H H Cl S O H O O thiamethoxam CGA 224 OA 4226 OA 4225 L Laying hens In a laying hen metabolism study, five Leghorn hens were dosed with [ C-thiazol]thiamethoxam via gelatin capsules for 4 consecutive days at.9 mg/kg bw/day, the equivalent of 2 ppm thiamethoxam in the feed (Rümbeli, 998, 2AM4). Eggs were collected twice daily. Birds were slaughtered 6 hours after the final doses for tissue collection. Body weights were.5.5 kg and daily feed consumption ranged from 94 to g. The nature of the feed and percentage of dry matter were not reported. Accountability of the administered C was acceptable at 9 89% for the five hens, with most ( 88%) of the C excreted in the droppings. Eggs accounted for an average of.96% of the C and tissues accounted for approximately.%. C residue levels were highest in liver and lowest in

10 96 Thiamethoxam fat tissues (Table 2). C residue levels in yolks and whites of eggs were reasonably close, with a plateau reached after approximately 2 4 days. In a second laying hen metabolism study, five White Leghorn hens were dosed with [ C- oxadiazin]thiamethoxam via gelatin capsules for 4 consecutive days at. mg/kg bw/day, the equivalent of 98 ppm thiamethoxam in the feed (Lutringer, 998, 2AM6). Eggs were collected twice daily. Birds were slaughtered 6 hours after the final doses for tissue collection. Body weights were.4. kg and daily feed consumption ranged from 96 to 5 g (9% dry matter). Accountability of the administered C was acceptable at 6 8% for the five hens, with most (2 82.6%) of the C excreted in the droppings. Eggs accounted for an average of.% of the C and tissues approximately.5%. C residue levels were highest in liver and lean meat and lowest in fat tissues (Table 2). C residue levels in whites and yolks of eggs were similar, with a plateau reached after approximately 2 days. Parent thiamethoxam was not the major residue component in any of the tissues or eggs. Metabolite CGA 265 was the major residue component in fat + skin and the eggs. Metabolite MU was the major residue component of lean meat while CGA 224 was the major component in the liver. Table 2 Distribution and identity of the residues in tissues and eggs of laying hens dosed with [ C- thiazol]thiamethoxam and [ C-oxadiazin]thiamethoxam via gelatin capsule for 4 consecutive days Residues expressed as thiamethoxam, as mg/kg or % TRR Lean meat Fat + skin Liver Liver a Egg white Egg yolk [ C-thiazol]thiamethoxam dosing equiv to 2 ppm in feed TRR.68 mg/kg.29 mg/kg 8. mg/kg 8. mg/kg.2 mg/kg.29 mg/kg on-extracted %.% 5%.%.8%.9% Thiamethoxam 2% 5% 5.% % CGA 265.% 54% b 5% 2% 45% b 69% b MU 9% b 8.% 22% 22% CGA 224.2% 9.2%.2% 4% b 25% 2% 8U 4.8%.%.2%.2% 2.4% L9.9%.9% OA %.% OA 446.8% 8.6% OA 4225 %.4%.% % [ C-oxadiazin]thiamethoxam dosing equiv to 98 ppm in feed TRR.9 mg/kg.42 mg/kg 9.2 mg/kg 9.2 mg/kg. mg/kg. mg/kg on-extracted 8.% 6.8% 49% 5.2%.4% 5.2% Thiamethoxam 2% 5.%.2%.2%.9% % CGA % 5% b 2% 6% 4% b 54% b MU % b.6% 2% 2% CGA 224.5%.% 2.8% 9% b 2% 2% 8U.% 4.5%.%.%.9%.9% CGA % 5.6% 4.2% L9.%.% OA 446.2%.8% 5% -methyl--.%.4%.2%.4%.2%.% nitroguanidine OA 445.8%.% 6.% OA %.4%.2%.2%.% a microwave assisted extraction. b major component of the residue

11 Thiamethoxam 9 Cl S O O 2 Cl S H H O 2 H Cl S H H 2 H O Cl S H H O 2 thiamethoxam CGA 265 MU CGA 224 Animal metabolism summary When animals were dosed with labelled thiamethoxam, the C was readily excreted in urine and faeces and an array of metabolites was produced. Unchanged parent thiamethoxam was the major component while CGA 224 (-(2- chlorothiazol-5-ylmethyl)-'-methyl-"-nitroguanidine) was the major metabolite identified in urine after rats were subjected to oral dosing with labelled thiamethoxam. When goats were dosed with labelled thiamethoxam, approximately % of the dose appeared in milk and 4% in the tissues. Metabolite CGA 224 was the major component of the residue in milk, while parent thiamethoxam was the major component in muscle, fat and kidney. Further degraded metabolites occurred in the liver. When laying hens were dosed with labelled thiamethoxam, most of the dose was excreted in the droppings. Eggs accounted for approximately.% of the administered dose and tissues approximately.5%. Parent thiamethoxam was not the major component of the residue in any tissue or eggs, but did constitute approximately 2% of the C in lean meat. Metabolite CGA 265 (-(2- chlorothiazol-5-ylmethyl)-'-nitroguanidine) was the major residue component in the eggs, in both egg whites and yolks and also in fat + skin. Metabolite CGA 224 (-(2-chlorothiazol-5-ylmethyl)- '-methyl-"-nitroguanidine) was the major residue component in liver while metabolite MU (amino-([(2-chlorothiazol-5-ylmethyl)-amino]-methylene)-hydrazide) was the major component of the lean meat residue.

12 98 Thiamethoxam Cl S S S COOH CGA 5968 OA COOH Cl H S S 2 H H HOOC 2 H H S CGA 95 H H Metab 6U -methylguanidine O O 2 Cl Cl H H S 2 H OH S OA 4226 H OA 446 O 2 Cl Cl Cl H H S H H S H H S O 2 OA 4225 H CGA 224 CGA 265 H O 2 Cl Cl Cl Cl O O Cl Cl S S H OA 445 Thiamethoxam O 2 O Cl H H S S CGA 5968 O CGA 559 O Cl O HOOC S H H S 2 S Metab 4U O H Metab U O O Cl H O O H O Cl S S S COOH S COOH Metab 6U Metab 5U O S Metab L H O O S H H MU2 H O O S H H 2 MU H O Figure 4 Proposed metabolic pathway for thiamethoxam in animals Plant metabolism The Meeting received plant metabolism studies with [ C]thiamethoxam in maize, rice, pears, cucumbers, lettuce and potatoes. Thiamethoxam is readily taken up from treated seed and translocated within the plant and it produces many metabolites. Parent thiamethoxam is usually an important component of the residue. Maize Maize seeds treated with [ C-oxadiazin]thiamethoxam formulated as a WS (water dispersible powder for slurry seed treatment) formulation at a rate equivalent to.5 kg ai/ha were sown to produce

13 Thiamethoxam 99 field-grown maize plants (Sandmeier, 996, 95PSA4PR). Samples of plants taken days after sowing, at forage stage 24 days after sowing, and fodder and grain samples taken at maturity 66 days after sowing, were analysed for total radioactive residue and for the composition of the residue. Data are summarised in Table. A considerable amount of C was taken up and translocated to the whole plant, as demonstrated by the TRR level of 8 mg/kg in the whole tops at day. At the longer intervals the TRR was much lower. umerous metabolites were observed in the forage and fodder, but concentrations were generally too low for identification. An overdose experiment was conducted where [ C-oxadiazin]thiamethoxam was applied to the soil around maize plants (two-leaf stage) at.485 kg ai/ha (Sandmeier, 996, 95PSA4PR). An overdose directly on the seed may have been phytotoxic, so soil treatment was chosen. Samples of forage taken 89 days after treatment and grain and fodder at maturity were examined for C content and composition of the residue (Table ). Residue was readily taken up from the soil and translocated to all parts of the plant. A number of metabolites were observed in the plant tissues at levels from % of TRR. The pattern was similar to that from seed treatment. To produce higher levels of metabolites for identification, indoor maize plants (2 days old, 6- leaf stage) were injected with [ C-oxadiazin]thiamethoxam at. mg thiamethoxam per plant (Sandmeier, 99, 95PSA4PR2). Grain leaf and stalk samples were taken 8 days after treatment for analysis and metabolite identification. The pattern of metabolites was similar to that from seed treatment, but levels were higher, which permitted identification. The identifications were then used in the interpretation of the seed treatment experiment. Table Distribution and identity of the residues in forage, fodder and grain of maize produced from seed treated with [ C-oxadiazin]thiamethoxam, soil treatment or stem injection Residues expressed as thiamethoxam, as mg/kg or % TRR Whole tops, Forage Grain Fodder a Stalks Leaves day [ C-oxadiazin]thiamethoxam seed treatment at.5 kg ai/ha TRR 8 mg/kg. mg/kg.5 mg/kg.24 mg/kg on-extracted.6% 2% 25% % Thiamethoxam. mg/kg.8 mg/kg.2 mg/kg. mg/kg Thiamethoxam 4%.9% 5%.% I = OA 4225.% 2% % CGA 265.%.9%.5% CGA % 9.8% 9.6%.6% CGA 542.% 4.%.2% CGA 559.%.4%.4% -methylguanidine.%.% 9.8% I = OA % 8.4% 8.5% -methyl--nitroguanidine 2.6%.% [ C-oxadiazin]thiamethoxam soil treatment at.485 kg ai/ha TRR.5 mg/kg.4 mg/kg. mg/kg on-extracted 2% 26% 4% Thiamethoxam.98 mg/kg.6 mg/kg.2 mg/kg Thiamethoxam % 5%.% I = OA %.9% 8.% CGA 265.% 2.2%.5% CGA 224 6% 6%.6% CGA 542.8% CGA %.6% -methylguanidine 4.6%.8% 9.% I = OA 445 % 2.5% 6.9% -methyl--nitroguanidine 2.% 4.%.8%

14 8 Thiamethoxam Residues expressed as thiamethoxam, as mg/kg or % TRR Whole tops, Forage Grain Fodder a Stalks Leaves day [ C-oxadiazin]thiamethoxam stem injection at. mg per plant. TRR.5 mg/kg. mg/kg 59 mg/kg on-extracted % 8.% 9.4% Thiamethoxam. mg/kg. mg/kg mg/kg a Fodder, 4% dry matter (seed treatment), 4% dry matter (soil treatment) In a second maize metabolism study, maize seeds treated with [ C-thiazol]thiamethoxam formulated as a WS formulation (water dispersible powder for slurry seed treatment) at a rate equivalent to.9 kg ai/ha were sown to produce field-grown maize plants (Sandmeier, 996, 95PSA4PR). Samples of plant taken and days after sowing, at forage stage 24 days after sowing, and fodder and grain samples taken at maturity 66 days after sowing, were analysed for total radioactive residue and for the composition of the residue. Data are summarised in Table 4. An overdose experiment was also conducted, as previously described, where [ C- thiazol]thiamethoxam was applied to the soil around maize plants (two-leaf stage) at.488 kg ai/ha (Sandmeier, 996, 95PSA4PR). Samples of forage taken 89 days after treatment and grain and fodder at maturity were examined for C content and composition of the residue (Table 4). The metabolite pattern was similar to that from seed treatment. As previously described for the oxadiazin- C label, indoor maize plants (2 days old, 6-leaf stage) were injected with [ C-thiazol]thiamethoxam at. mg thiamethoxam per plant (Sandmeier, 99, 95PSA4PR2). Grain, leaf and stalk samples were taken 8 days after treatment for analysis and metabolite identification. The pattern of metabolites was similar to that from seed treatment, but levels were higher, which permitted identification. The identifications were then used in the interpretation of the seed treatment experiment (Table 4). Table 4 Distribution and identity of the residues in forage, fodder and grain of maize produced from seed treated with [ C-thiazol]thiamethoxam, soil treatment Residues expressed as thiamethoxam, as mg/kg or % TRR Tops, day Roots, day Tops, day Forage Grain Fodder a [ C-thiazol]thiamethoxam seed treatment at.9 kg ai/ha TRR 4 mg/kg mg/kg mg/kg. mg/kg.2 mg/kg.5 mg/kg on-extracted.9% 4.9%.9% 25% 65% 49% Thiamethoxam 6 mg/kg mg/kg 6.5 mg/kg.9 mg/kg.2 mg/kg.5 mg/kg Thiamethoxam 4% 8.% 6.5% 4.% I = OA % 2% % CGA 265.% 2.8%.% CGA 224.9% 2%.5% 4.% CGA %.2%.5% I = OA % 8.8%.% [ C-thiazol]thiamethoxam soil treatment at.488 kg ai/ha TRR.4 mg/kg.8 mg/kg b.88 mg/kg b on-extracted 6% 62% 42% Thiamethoxam. mg/kg.6 mg/kg.4 mg/kg Thiamethoxam %.9% 5.% I = OA %.2% 9.5% CGA 265.%.4%.5% CGA 224 % 9.2%.9% CGA 559.6%.4%.4% I = OA %.5%.% a Fodder, 9% dry matter (seed treatment), 4% dry matter (soil treatment). b Samples of this maize grain and fodder were subsequently analysed by analytical method AG-65 (Campbell, 998, 46).

15 Thiamethoxam 8 The composition of the residue from seed treatment was quite similar for the different C label positions. In maize grain, thiamethoxam and CGA 224 were the most important identified components. In maize forage and fodder, thiamethoxam, OA 4225, CGA 224 and OA 445 were the main identified components (above % TRR). Cl S O O 2 Cl S H H O 2 Cl S H H H Cl S O H thiamethoxam CGA 224 OA 4225 OA 445 Rice Krauss (99, 95JKPR) studied the metabolism of thiamethoxam in greenhouse-grown paddy rice after [ C-oxadiazin]thiamethoxam formulated as granules was applied at a rate of.5 g ai/seedling box ( 6 cm), equivalent to. kg ai/ha when rice plants were at the 2 leaf stage 24 hours prior to planting out. Plant samples, taken, 4 and days after application and grain, husks and straw at maturity 26 days after application, were analysed for TRR and examined for metabolite distribution. Release of C into the paddy water was rapid, reaching a maximum 2% of the applied dose approximately week after the application. C was readily translocated to all parts of the plant. Approximately 5 metabolite fractions were observed in the plant parts at harvest. The distribution of identified metabolites is summarised in Table 5. In an analogous and parallel project, Krauss (99, 95JK5PR) studied the metabolism of thiamethoxam in greenhouse-grown paddy rice with [ C-thiazol]thiamethoxam at the same rate and timing. The non-extracted C in grains, husk and straw from both rice studies was subjected to vigorous extraction followed by base, acid and enzyme hydrolysis. Most of the C had apparently been incorporated into starch, cellulose, hemicellulose or proteins. Table 5 Distribution and identity of the residues in foliage, grain, husks and straw of rice produced after seedling bed treatment with [ C-oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam at the equivalent of. kg ai/ha Residues expressed as thiamethoxam, as mg/kg or % TRR Leaves, Leaves, day 4 Leaves, day Grain Husks Straw day [ C-oxadiazin]thiamethoxam seedling bed treatment at. kg ai/ha TRR 2 mg/kg.2 mg/kg. mg/kg.2 mg/kg.5 mg/kg 2.8 mg/kg on-extracted.6% 6% % 88% 45% 2% Thiamethoxam mg/kg.5 mg/kg.6% <. mg/kg.5 mg/kg.8 mg/kg Thiamethoxam 94% 4% 2% 6.5% 2% I = OA 445.% 4.8%.% 2.8% 5.8% Ia = -methylurea 2.9% 5.2%.4%.8%.6% CGA 265.% 4.%.% 2.9% CGA 224 % %.% 6%.% CGA 559.5% 6.5%.2% 6.5% 2% [ C-thiazol]thiamethoxam seedling bed treatment at. kg ai/ha TRR 24 mg/kg.4 mg/kg.65 mg/kg.8 mg/kg.6 mg/kg. mg/kg on-extracted.% % 24% 8% 4% 2% Thiamethoxam 2 mg/kg.5 mg/kg.98 mg/kg <. mg/kg..52 mg/kg Thiamethoxam 84% 25% 5% 22% %

16 82 Thiamethoxam Residues expressed as thiamethoxam, as mg/kg or % TRR Leaves, Leaves, day 4 Leaves, day Grain Husks Straw day CGA % 2.5%.% CGA 265.5% 2.%.2%.9% 2.5% CGA % % % 2.% % 5.% CGA %.% 2.%.4%.9% Krauss (99, 95JK8PR) studied the metabolism of thiamethoxam in greenhouse-grown paddy rice after [ C-oxadiazin]thiamethoxam formulated as a wettable powder was sprayed twice on the foliage, at a rate per application equivalent to.25 kg ai/ha, at booting stage 49 days after transplanting and 5 days later, 2 days before harvest. Grains, husk and straw were analysed for TRR and composition of the residue. Results are summarised in Table 6. Parent thiamethoxam was the major identified component of the residue in grain, husks and straw. Most of the C in the grain was not extracted even after microwave extraction at ºC. This was similar to the situation with granular application where the unextracted C was found to be incorporated into starch, cellulose, hemicellulose or proteins. In an analogous and parallel project, Krauss (99, 95JK6PR) studied the metabolism of thiamethoxam in greenhouse-grown foliar-treated paddy rice with [ C-thiazol]thiamethoxam at the same rate and similar timing (48 days after transplanting and 5 days later, 2 days before harvest). Grains, husk and straw were analysed for TRR and composition of the residue. Results are summarised in Table 6. Parent thiamethoxam was again the major identified component of the residue. The high percentage non-extracted residue in grain was again attributed to incorporation into natural plant components. The nature of the residue was quite similar for the two C label positions, which reflects the fact that the major metabolites include both labelled positions. Table 6 Distribution and identity of the residues in grain, husks and straw of rice produced after foliar treatment with [ C-oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam at the equivalent of.25 kg ai/ha Residues expressed as thiamethoxam, as mg/kg or % TRR Grain Husks Straw [ C-oxadiazin]thiamethoxam 2 foliar treatments at.25 kg ai/ha TRR.26 mg/kg.96 mg/kg.8 mg/kg on-extracted 6% 6.% 6.% Thiamethoxam. mg/kg.6 mg/kg.5 mg/kg Thiamethoxam % 65% 5% CGA 265.5%.%.8% CGA 224 % 6.%.% CGA %.8%.8% CGA 559.%.%.2% [ C-thiazol]thiamethoxam 2 foliar treatments at.25 kg ai/ha TRR.5 mg/kg.6 mg/kg. mg/kg on-extracted 9%.5%.5% Thiamethoxam.2 mg/kg.82 mg/kg.5 mg/kg Thiamethoxam 4.5% % 5% CGA 265.4%.% 5.2% CGA %.6% % CGA 5968.%.9%.% CGA 559.% 4.4% 2.6% Pears Capps (998, ABR-984) sprayed Bartlett pear trees with labelled (thiazole and oxadiazin) thiamethoxam WP formulation in late season two cover sprays days apart with the second spray

17 Thiamethoxam 8 5 days before harvest. At the treatment, the application rate was.5 kg ai/ha per treatment and at treatment, the rate was.5 kg ai/ha per treatment. Fruit were harvested at normal maturity; foliage samples were taken after the second treatment and at harvest. Samples were analysed for C content and were examined for the nature of the residue. The C residue levels and composition of the residues are summarised in Table. TRR levels in leaves at the.5 kg ai/ha treatment rate were 4, 4, 6 and 5 mg/kg and at the high treatment rate (.5 kg ai/ha) were 5, 42, 65 and 45 mg/kg, i.e. levels were proportional to application rates. Levels in fruit were also approximately proportional to application rates. Thiamethoxam and CGA 224 were the major identified components of the residue, together accounting for approximately 5% of the TRR. Table Distribution and identity of the residues in pears produced after foliar treatment of Bartlett pear trees with [ C-oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam Residues in fruit expressed as thiamethoxam, as mg/kg or % TRR [ C-oxadiazin]thiamethoxam [ C-thiazol]thiamethoxam Rate =.5 kg ai/ha Rate =.5 kg ai/ha Rate =.5 kg ai/ha Rate =.5 kg ai/ha TRR. mg/kg. mg/kg.49 mg/kg 6.8 mg/kg on-extracted 9.% 4.6%.2%.% Thiamethoxam.96 mg/kg 2.2 mg/kg. mg/kg 2. mg/kg Thiamethoxam % b % b 29% b % b CGA 224 9% b % b 24% b 9% b CGA 224-O-.%.9%.%.% glucoside a CGA % 8.4% 5.% 8.% CGA 265.% 2.9% 4.8%.5% CGA 559.% 2.8%.6% 2.% Metab 4U = desmethyl-.8%.%.5% 2.9% CGA methyl--nitroguanidine.8% -methylguanidine.6% OA % 2.5% a CGA 224-O-glucoside is the hydroxylamine glucoside of CGA 224 b Major identified components of the residue Cucumbers Carlin (998, ABR-9848) sprayed cucumber plots twice with labelled (thiazole and oxadiazin) thiamethoxam WP formulation as foliar sprays first spray at full flowering and the second days later, days prior to mature harvest. At the.5 treatment, the application rate was.5 kg ai/ha per treatment. In the treatment, the first application was as a soil drench at.5 kg ai/ha in a band at the first true leaf stage and the second was a foliar spray at.5 kg ai/ha, days prior to mature harvest. Fruit samples were harvested for analysis and for residue identification. The TRR and composition of the residues are summarised in Table 8. OA 445 and thiamethoxam were the major identified components of the residue, together accounting for approximately 4% the TRR. Table 8 Distribution and identity of the residues in cucumbers produced after treatment of cucumber plots with [ C-oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam Residues in cucumbers expressed as thiamethoxam, as mg/kg or % TRR [ C-oxadiazin]thiamethoxam [ C-thiazol]thiamethoxam Rate =.5 kg ai/ha Rate =.5 + Rate =.5 kg ai/ha Rate = kg ai/ha.5 kg ai/ha TRR. mg/kg.2 mg/kg.5 mg/kg. mg/kg on-extracted 6.5% 6.% % % Thiamethoxam. mg/kg.44 mg/kg.6 mg/kg. mg/kg

18 84 Thiamethoxam Residues in cucumbers expressed as thiamethoxam, as mg/kg or % TRR [ C-oxadiazin]thiamethoxam [ C-thiazol]thiamethoxam Rate =.5 kg ai/ha Rate =.5 + Rate =.5 kg ai/ha Rate = kg ai/ha.5 kg ai/ha Thiamethoxam 9.2% b % b 6% b 9.6% b OA 445 % b % b 2% b 2% b CGA 224.%.5%.%.2% CGA %.%.%.9%.%.6%.4%.4% a Also quoted as CGA-59 in ABR b Major identified components of the residue Lettuce Sandmeier (999, 99PSA52) made three foliar sprays to field grown lettuce (cv. Sunny) at weekly intervals with labelled (thiazole and oxadiazin) thiamethoxam WG formulation. Application rates were equivalent to.54 and.52 kg ai/ha. Lettuce plants were harvested,, and days after the final application for analysis and metabolite identification (Table 9). Auxiliary experiments with overdose rates (.5 kg ai/ha) generated higher residue levels to assist with metabolite identification. Parent thiamethoxam was the major component of the residue accounting for approximately 4% of the residue days after the final treatment. The non-extracted residue fraction accounting for % and 9% of TRR was subjected to hot methanol extraction and acid and base hydrolysis. Most of the released C material was of a very polar nature and was probably incorporated into natural plant components as already found with maize metabolism. Table 9 Distribution and identity of the residues in lettuce after treatment three times with [ C- oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam at a rate equivalent to.54 and.52 kg ai/ha and harvested,, and days after the final treatment Residues in lettuce expressed as thiamethoxam, as mg/kg or % TRR Day Day Day Day thiazol oxadiazin thiazol oxadiazin thiazol oxadiazin thiazol oxadiazin TRR.4 mg/kg.98 mg/kg. mg/kg.5 mg/kg.6 mg/kg.2 mg/kg.5 mg/kg.69 mg/kg ot extracted 5.8% 4.% 9.4% 6.5% 2% 8.4% 9% % Thiamethoxam.44 mg/kg.55 mg/kg.6 mg/kg.6 mg/kg.5 mg/kg.4 mg/kg.24 mg/kg.26 mg/kg Thiamethoxam 8% 8% 66% % 55% 5% 42% 8% CGA 265.%.2%.2%.%.2%.4%.5%.% CGA % 2.%.%.2%.5%.8% 5.8% 5.6% CGA %.% 4.6% 6.6% CGA %.% 2.%.8% 2.4%.9% 2.4% 2.5% CGA %.4%.4%.6% 2.%.4%.% 2.% conj a CGA 559.8%.4%.% 2.9% 2.6% 2.%.8%.9% CGA 5968.%.%.4%.% CGA 829.%.% 2.2%.8% Methylurea.%.4%.%.5% OA %.% 6.8%.9% OA %.4%.2% 2.4% 5.% 4.% 6.2% 4.% OA %.2%.%.4%.6%.5% 2.2%.8% OA %.%.%.5% Metab 4U.%.%.%.2%.5%.5%.4%.9% I b 2.%.6%.%.% 5.6%.6% 6.% 2.% a -glucose conjugate of CGA b Mixture of O-glucose conjugate of CGA 49 (thiazol label only) and O-glucose conjugate of -(2-clorothiazol-5- ylmethyl)--hydroxymethyl--methylurea

19 Thiamethoxam 85 Potatoes In a metabolism study on potatoes, Capps (999, 6 99) sowed potato seed-pieces treated with [ C- thiazol]thiamethoxam and [ C-oxadiazin]thiamethoxam at ( ).5 kg ai/ kg of tubers. An overdose experiment ( 5) at.5 kg ai/ kg of tubers provided higher residue levels to assist with metabolite identification. Tubers and foliage were harvested 84 days (new potato size) and 6 days (mature harvest) after sowing for TRR analysis and to determine the composition of the residue. Capps and Brown (2, 6-99 amendment ) continued with identification of residue components. The results from the potato treatments are summarised in Table. Parent thiamethoxam was the major identified residue in the harvested potatoes at 2% of TRR. Metabolite CGA 224 was present at 6 % of TRR. Metabolite CGA 29 constituted approximately 6 % TRR while CGA 49 and its conjugate also accounted for approximately 6 % TRR. A number of other metabolites were identified, but none exceeded % TRR. o further metabolites were identified when the non-extracted fraction was subjected to vigorous extraction and hydrolysis, which generally produced a mixture of polar compounds, suggesting that much of the non-extracted C was associated with polysaccharides and cellulose. Table Distribution and identity of the residues in potato tubers after potato seed-pieces were treated with [ C-oxadiazin]thiamethoxam or [ C-thiazol]thiamethoxam at the equivalent of.5 kg ai/ kg of tubers and the crop was grown to maturity Residues in potatoes expressed as thiamethoxam, as mg/kg or % TRR ew potatoes, day 84 Mature potatoes, day 6 thiazol oxadiazin thiazol oxadiazin TRR.2 mg/kg.25 mg/kg.22 mg/kg. mg/kg ot extracted 24%.8% 25% 5% Thiamethoxam.58 mg/kg.5 mg/kg.29 mg/kg. mg/kg Thiamethoxam 8% 2% % % CGA 265.%.% 2.8%. CGA % % 6.2% 6.% CGA % 2.5% 2.%.6% CGA 5968 conj a.4%.% 2.5% OA %.8%.%.% CGA % 6.% CGA % 4.4% CGA 49.5%.4% CGA 49 conj b 6.% 2.2% CGA 542.5% CGA 829.2% OA %.% OA % OA 4226 conj c 2.9% 2.2%.2% OA CGA 829.% a -glucoside conjugate of CGA b Glucoside + malonyl-glucoside of CGA 49. c Hydroxylamine glucoside conjugate of OA Plant metabolism summary Thiamethoxam was mobile within the plant and it produced an array of metabolites. Metabolic degradation pathways were similar in the various plants tested: maize, rice, pears, cucumbers, lettuce and potatoes. Parent thiamethoxam and metabolite CGA 224 (-(2-chlorothiazol-5-ylmethyl)-'- methyl-"-nitroguanidine) appeared in plant metabolism profiles above % TRR more often than other metabolites. Other metabolites to appear above % TRR were: -methylguanidine, CGA 29 (,6-dihydro--methyl--nitro-2H-,,5-oxadiazin-4-amine), CGA 559 (-(2- chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-one), OA 445 (-(2-chlorothiazol-5-

20 86 Thiamethoxam ylmethyl)-5-methyl-[,,5]oxadiazinan-4-ylidineamine) and OA 4225 (-(2-chlorothiazol-5- ylmethyl)-'-methyl-guanidine). These metabolites are shown in the proposed metabolic pathway for thiamethoxam in plants (Figure 5). Cl S H H Cl S H H O H OA 4225 H CGA 224 O 2 O2 CGA 29 H 2 H H Cl S O Cl S O -methylguanidine Thiamethoxam O 2 OA 445 H Cl S O CGA 559 O Figure 5 Proposed metabolic pathway for thiamethoxam in plants umerous other compounds were identified as plant metabolites. The metabolites that exceeded % TRR in at least one case, but did not exceed % TRR are shown in Figure 6. H O 2 H Cl S H H O 2 H O H H O2 Cl S CH 2 OH -Methyl--nitroguanidine CGA 265 CGA 455 CGA 49 H O H Cl S H O H Cl S COOH CGA 542 CGA 5968 CGA 5968

21 Thiamethoxam 8 Cl S H O H 2 H O H 2 H 2 O 2 H 2 Cl S H H H 2 Metab 4U Methylurea -nitroguanidine OA OA 4226 Figure 6 Plant metabolites that exceeded % of TRR in at least one case, but did not exceed % of TRR in any case. -nitroguanidine was the only plant metabolite that did not also appear as an animal metabolite. -nitroguanidine is also an industrial chemical used in the manufacture of high explosives, especially flashless powder (with nitrocellulose). It is also a chemical intermediate (Chemwatch, 24). Environmental fate in soil The FAO Manual explains the data requirements for studies of environmental fate. The focus should be on those aspects that are most relevant to the MRL setting. For thiamethoxam, supervised residue trials data are available for seed dressings, root and tuber vegetables and rice, which means that aerobic degradation in soil and soil photolysis are relevant, as well as the normal requirements for hydrolysis and rotational crop studies. Soil metabolism When [ C-thiazol]thiamethoxam was incubated with five soils under aerobic conditions at 2 ºC and 4% field moisture capacity, it disappeared with half-lives from to days (Adam, 996, 95DA). CGA 224 was the main metabolite. CGA 559 and five other unidentified minor metabolites were also observed. Ellgehausen (998, 98EH5) calculated the degradation half-life of CGA 224 in the Collombey loamy sand as 5 days Aerobic soil metabolism Ref: Adam, 996, 95DA Test material: [ C-thiazol]thiamethoxam Dose rate:.5 mg ai/kg dry weight Duration: 8 days Temp:2 ± 2 C Moisture: 4% max water holding capacity Soil: loamy sand (Collombey) ph:.4 Organic carbon:.% Half-life thiamethoxam: 96 days C accountability: 96 % % thiamethoxam remaining, day 8 = 52% of dose % mineralization, day 8 =.5% of dose % unextracted, day 8 = % of dose Metabolites Max (% of dose) Day CGA 224.% 5 CGA 559.% 5 Aerobic soil metabolism Ref: Adam, 996, 95DA Test material: [ C-thiazol]thiamethoxam Dose rate:.5 mg ai/kg dry weight Duration: 8 days Temp:2 ± 2 C Moisture: 4% max water holding capacity Soil: sand (Speyer 2.) ph: 8.2 Organic carbon:.6% Half-life thiamethoxam: days C accountability: 9 % % thiamethoxam remaining, day 8 = 6% of dose % mineralization, day 8 = 2% of dose % unextracted, day 8 = 6% of dose Metabolites Max (% of dose) Day CGA % 8 Aerobic soil metabolism Ref: Adam, 996, 95DA Test material: [ C-thiazol]thiamethoxam Dose rate:.5 mgai/kg dry weight Duration: 8 days Temp:2 ± 2 C Moisture: 4% max water holding capacity

22 88 Thiamethoxam Soil: sandy loam (Weide) ph:.6 Organic carbon:.% Half-life thiamethoxam: 6 days C accountability: 96 5% % thiamethoxam remaining, day 8 = 4% of dose % mineralization, day 8 = 2% of dose % unextracted, day 8 = 2.5% of dose Metabolites Max (% of dose) Day CGA 224 5% 8 CGA 559.2% 8 Aerobic soil metabolism Ref: Adam, 996, 95DA Test material: [ C-thiazol]thiamethoxam Dose rate:.49 mg ai/kg dry weight Duration: 2 days Temp:2 ± 2 C Moisture: 4% max water holding capacity Soil: loamy sand (Pappelacker) ph:.6 Organic carbon:.% Half-life thiamethoxam: days C accountability: 9 % % thiamethoxam remaining, day 2 = 55% of dose % mineralization, day 2 = 2% of dose % unextracted, day 2 =.6% of dose Metabolites Max (% of dose) Day CGA 224 % 2 Aerobic soil metabolism Ref: Adam, 996, 95DA Test material: [ C-thiazol]thiamethoxam Dose rate:.49 mg ai/kg dry weight Duration: 2 days Temp:2 ± 2 C Moisture: 4% max water holding capacity Soil: sandy loam (Weide) ph:.5 Organic carbon:.% Half-life thiamethoxam: 8 days C accountability:8-% % thiamethoxam remaining, day 2 = 6% of dose % mineralization, day 2 = % of dose % unextracted, day 2 = 9.6% of dose Metabolites Max (% of dose) Day CGA 224 9% 2 CGA 559.2% 62 Phaff (99, 95RP) studied the effects of moisture level, temperature and dose level on the persistence of thiamethoxam and metabolite CGA 224 in a soil under aerobic conditions in the dark. Higher temperature, higher moisture level and lower dose rate all increased the disappearance rate of thiamethoxam. Metabolite CGA 224 reached 6% (expressed as thiamethoxam) of the dose applied to the soil. Details are summarised below. Aerobic soil metabolism Ref: Phaff, 99, 95RP Test material: [ C-thiazol]thiamethoxam Dose rate:.9 mg ai/kg Duration: 6 days Temp: 2 C Moisture: 6% field moisture capacity Soil: silty loam ph:.5 Organic carbon: 2.5% Half-life thiamethoxam: 4 days C accountability: 8% % thiamethoxam remaining, day 6 = 4.2% of dose % mineralization, day 6 = 2% of dose % unextracted, day 6 = 6% of dose Metabolites Max (% of dose) Day CGA % Aerobic soil metabolism Ref: Phaff, 99, 95RP Test material: [ C-thiazol]thiamethoxam Dose rate:.9 mg ai/kg Duration: 6 days Temp: 2 C Moisture: 4% field moisture capacity Soil: silty loam ph:.5 Organic carbon: 2.5% Half-life thiamethoxam: days C accountability: 69 % % thiamethoxam remaining, day 6 =.6% of dose % mineralization, day 6 = 24% of dose % unextracted, day 6 = 2% of dose Metabolites Max (% of dose) Day CGA 224 % 89 Aerobic soil metabolism Ref: Phaff, 99, 95RP Test material: [ C-thiazol]thiamethoxam Dose rate:.9 mg ai/kg Duration: 6 days Temp: C Moisture:6% field moisture capacity Soil: silty loam ph:.5 Organic carbon: 2.5% Half-life thiamethoxam: 2 days C accountability: 9 % % thiamethoxam remaining, day 6 = 4% of dose % mineralization, day 6 = % of dose

23 Thiamethoxam 89 % unextracted, day 6 = 8.4% of dose Metabolites Max (% of dose) Day CGA % 6 Aerobic soil metabolism Ref: Phaff, 99, 95RP Test material: [ C-thiazol]thiamethoxam Dose rate:. mg ai/kg Duration: 6 days Temp: 2 C Moisture:6% field moisture capacity Soil: silty loam ph:.5 Organic carbon: 2.5% Half-life thiamethoxam: 4 days C accountability: 8 2% % thiamethoxam remaining, day 6 =.% of dose % mineralization, day 6 = 44% of dose % unextracted, day 6 = % of dose Metabolites Max (% of dose) Day CGA 224 6% 9 Cruz (998, ABR-9846) incubated [ C-oxadiazin]thiamethoxam in a clay loam soil for 2 months at 25 ºC in the dark and observed the disappearance of parent compound with a half-life of approximately days. The disappearance rate from sterilized soil was much slower. Aerobic soil metabolism Ref: Cruz, 998, ABR-9846 Test material: [ C-oxadiazin]thiamethoxam Dose rate:.9 mg/kg Duration: 2 months Temp: 25 C Moisture: 5 ± 2% field moisture capacity Soil: clay loam viable ph:.6 Organic carbon: 2.5% Half-life thiamethoxam: days C accountability: 92 5% % thiamethoxam remaining, 2 months = 9.% of dose % mineralization, 2 months = 9% of dose % unextracted, 2 months = 6.9% of dose Metabolites Max (% of dose) Month CGA % Month CGA % Month 6 CGA 559 2% Month 6 CGA % Month 2 Aerobic soil Ref: Cruz, 998, ABR-9846 Test material: [ C-oxadiazin]thiamethoxam Dose rate:.9 mg/kg Duration: 6 months Temp: 25 C Moisture: 5 ± 2% field moisture capacity Soil: clay loam sterile ph:.6 Organic carbon: 2.5% Half-life thiamethoxam: 6 months data too short for calculation C accountability: 9 % % thiamethoxam remaining, 6 months = 8% of dose % mineralization, 6 months = 2.% of dose % unextracted, 6 months = % of dose Degradates Max (% of dose) Month CGA 224.5% Month 6 CGA % Month 6 Dixon (998, ABR9659) incubated [ C-thiazol]thiamethoxam in a sandy loam soil under aerobic conditions for 65 days, comparing metabolism in the viable soil and effects in the sterilized soil. The long term rates of disappearance of thiamethoxam were similar in viable and sterilized soil. However, growth was observed in the microbial test of the 'sterile' soil after 9 days of incubation and substantial counts of bacteria and fungi were observed on days and 65, which demonstrates that the sterilized soil did not remain sterile for the duration of the test. Aerobic soil metabolism Ref: Dixon, 998, ABR-9659 Test material: [ C-thiazol]thiamethoxam Dose rate:.9 mg ai/kg Duration: 65 days Temp: 25 C Moisture: 5% field moisture capacity Soil: sandy loam viable ph:. Organic matter:.6% Half-life thiamethoxam: approx 4 days C accountability: 88 2% % thiamethoxam remaining, day 65 = 46% of dose % mineralization, day 65 =.4% of dose % unextracted, day 65 = % of dose Metabolites Max (% of dose) Day CGA % 82

24 8 Thiamethoxam CGA CGA % 268 Aerobic soil Ref: Dixon, 998, ABR-9659 Test material: [ C-thiazol]thiamethoxam Dose rate:.9 mg ai/kg Duration: 65 days Temp: 25 C Moisture: 5% field moisture capacity Soil: sandy loam sterilized. ote 8 ph:. Organic matter:.6% Half-life thiamethoxam: approx days C accountability: 94 % % thiamethoxam remaining, day 65 = 4% of dose % mineralization, day 65 = 5.8% of dose % unextracted, day 65 = 8% of dose Degradates Max (% of dose) Day CGA % 65 CGA % 65 CGA %% 65 Schwarz (998, ABR-9684) incubated [ C-oxadiazin]thiamethoxam in a sandy loam soil under aerobic conditions for 65 days, comparing metabolism in the viable soil with effects in the sterilized soil. The rates of disappearance were similar. Aerobic soil metabolism Ref: Schwarz, 998, ABR-9684 Test material: [ C-oxadiazin]thiamethoxam Dose rate:.9 mg ai/kg Duration: 65 days Temp: 25 ± C Moisture: 5% field moisture capacity Soil: sandy loam viable ph:. Organic matter:.6% Half-life thiamethoxam: approx 4 days C accountability: 8 % % thiamethoxam remaining, day 65 = 42% of dose % mineralization, day 65 = % of dose % unextracted, day 65 = 25% of dose Metabolites Max (% of dose) Day CGA 224.8% 65 CGA 29.4% 2 CGA 559.8% 2 CGA Aerobic soil Ref: Schwarz, 998, ABR-9684 Test material: [ C-oxadiazin]thiamethoxam Dose rate:.9 mg ai/kg Duration: 65 days Temp: 25 ± C Moisture: 5% field moisture capacity Soil: sandy loam sterile ph:. Organic matter:.6% Half-life thiamethoxam: approx 4 days C accountability: 94 6% % thiamethoxam remaining, day 65 = 54% of dose % mineralization, day 65 =.6% of dose % unextracted, day 65 = % of dose Degradates Max (% of dose) Day CGA 224.8% 65 CGA 29.% 8 CGA 559.2% 8 CGA Adam (999, 99DA) found similar disappearance rates of [ C-thiazol]thiamethoxam and [ C-thiazol]CGA 224 in a loamy sand at 2 ºC under aerobic conditions. The main metabolite identified from CGA 224 metabolism was CGA 265, resulting from a demethylation of CGA 224. Aerobic soil metabolism Ref: Adam, 999, 99DA Test material: [ C-thiazol]thiamethoxam Dose rate:.26 mg ai/kg dry soil Duration: 8 days Temp: 2 C Moisture: 4% max water holding capacity Soil: loamy sand (Borstel soil) ph: 5. Organic carbon:.2% Half-life thiamethoxam: approx 2 days C accountability: 9 % % thiamethoxam remaining, day 8 = 9% of dose % mineralization, day 8 = 4.2% of dose % unextracted, day 8 = 4.% of dose 8 Sterilized soil did not remain sterile for the duration.

25 Thiamethoxam 8 Metabolites Max (% of dose) Day CGA 224.4% 8 Aerobic soil metabolism Ref: Adam, 999, 99DA Test material: [ C-thiazol]CGA 224 Dose rate:. mg test material/kg dry soil Duration: 8 days Temp: 2 C Moisture: 4% max water holding capacity Soil: loamy sand (Borstel soil) ph: 5. Organic carbon:.2% Half-life CGA 224: approx 2 days C accountability: 9 2% % CGA 224 remaining, day 8 = 8% of dose % mineralization, day 8 = 8.% of dose % unextracted, day 8 =.8% of dose Metabolites Max (% of dose) Day CGA 265.2% 62 8 When [ C-thiazol]thiamethoxam was exposed to a paddy soil system, thiamethoxam disappeared with a half-life of approximately 5 days (Adam, 99, 96DA4 and Amendment ). The main metabolite was OA 445, produced under the reducing conditions. After 6 days, most of the dose had become unextracted residue, 6% remaining after harsh extraction. Fulvic and humic acids constituted 9% of the dose, but the remainder of the unextracted C was not characterised. Paddy soil metabolism Ref: Adam, 99, 96DA4 and Amendment Test material: [ C-thiazol]thiamethoxam Dose rate:.5 mg ai/kg dry soil, applied to water Duration: 6 days Temp: 25 ± 2 C 5 cm soil + water layer 2 cm above soil Soil: paddy soil ph: 5. (KCl) Organic carbon:.9% ph water: Half-life thiamethoxam: approx 5 days C accountability: 95 2% % thiamethoxam remaining, day 6 = 2.% of dose % mineralization, day 6 = 2.2% of dose % unextracted, day 6 = 6% of dose Metabolites Max (% of dose) Day OA 445 9% 2 82 CGA 224 disappeared from a sandy loam soil at 2 ºC under aerobic conditions with a half-life of approximately 2 days (Adam, 999, 99DA6). The main identified metabolite was CGA 265. Aerobic soil metabolism Ref: Adam, 999, 99DA6 Test material: [ C-thiazol]CGA 224 Dose rate:.2 mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: 4% max water holding capacity Soil: sandy loam, Schwaderloch soil ph:.4 Organic carbon:.2% Half-life CGA 224: approx 2 days C accountability: 9 % % CGA 224 remaining, day 2 = 64% of dose % mineralization, day 2 = 2% of dose Metabolites Max (% of dose) Day CGA % 2 % unextracted, day 2 =.5% of dose Hein and Dorn (2, OV) found % of the applied [ C-thiazol]CGA 224 remained 2 days after treatment of a loamy sand followed by maintenance of aerobic conditions at 2 ºC. In that time, % of the dose had mineralized and % was in the unextracted fraction. Aerobic soil metabolism Ref: Hein and Dorn, 2, OV Test material: [ C-thiazol]CGA 224 Dose rate:.82 mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: 4% max water holding capacity Soil: loamy sand (Birkenheide) ph: 6. (CaCl 2 ) Organic carbon:.9% Half-life CGA 224: approx 2 days C accountability: 92 5% % CGA 224 remaining, day 2 = % of dose % mineralization, day 2 = % of dose % unextracted, day 2 = % of dose

26 82 Thiamethoxam Aerobic soil metabolism Ref: Hein and Dorn, 2, OV Metabolites Max (% of dose) Day no identifications The fate of CGA 559 was investigated in three soils at 2 ºC under aerobic conditions for 2 days (Indergand and icollier, 24, T2-4). CGA 559 disappeared readily (5 days half-life) in two of the soils, but was more persistent in the third. CGA 5968 was the only identified metabolite. Aerobic soil metabolism Ref: Indergand & icollier, 24, T2-4 Test material: [ C-thiazol]CGA 559 Dose rate:. mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: 42 g water/ g dry soil Soil: silt loam, 'Gartenacker' ph:.4 (KCl) Organic carbon:.4% Half-life CGA 559: approx 5 2 days C accountability: 9 % % CGA 559 remaining, day 2 =.2% of dose % mineralization, day 2 = 6% of dose % unextracted, day 2 = 5% of dose Metabolites Max (% of dose) Day CGA % Aerobic soil metabolism Ref: Indergand & icollier, 24, T2-4 Test material: [ C-thiazol]CGA 559 Dose rate:. mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: g water/ g dry soil Soil: sandy clay loam, '8 acres' ph: 6. (KCl) Organic carbon:.8% Half-life CGA 559: approx 25 days C accountability: 9 % % CGA 559 remaining, day 2 = 4.6% of dose % mineralization, day 2 = 22% of dose % unextracted, day 2 = % of dose Metabolites Max (% of dose) Day CGA % 9 Aerobic soil metabolism Ref: Indergand & icollier, 24, T2-4 Test material: [ C-thiazol]CGA 559 Dose rate:. mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: 22 g water/ g dry soil Soil: silty clay loam, 'Marsillargues' ph:. (KCl) Organic carbon:.98% Half-life CGA 559: approx days C accountability: 9 2% % CGA 559 remaining, day 2 = 4% of dose % mineralization, day 2 = 8% of dose % unextracted, day 2 = % of dose Metabolites Max (% of dose) Day CGA 5968 % 2 Aerobic soil metabolism Ref: Buckel, 2, MO Test material: [ C-oxadiazin]OA 445 Dose rate:.2 mg test material/kg dry soil Duration: 2 days Temp: 2 C Moisture: 4% max water holding capacity Soil: silt loam, 'Gartenacker' ph:. (KCl) Organic carbon: 2.% Half-life OA 445: more than days C accountability: 5 % % OA 445 remaining, day 2 = 86% of dose % mineralization, day 2 = % of dose % unextracted, day 2 = 4.% of dose Metabolites Max (% of dose) Day OA % 2 Aerobic soil metabolism Ref: Indergand & icollier, 24, T22-4 Test material: [ C-oxadiazin]OA 445 Dose rate:. mg test material/kg dry soil Duration: 2 days Temp: 2 ± 2 C Moisture: g water/ g dry soil Soil: sandy clay loam, '8 acres' ph: 6. (KCl) Organic carbon:.8% Half-life OA 445: more than days C accountability: 9 % % OA 445 remaining, day 2 = % of dose % mineralization, day 2 =.% of dose % unextracted, day 2 % of dose Metabolites Max (% of dose) Day no identifications, low levels Aerobic soil metabolism Ref: Indergand & icollier, 24, T22-4

27 Thiamethoxam 8 Test material: [ C-oxadiazin]OA 445 Dose rate:. mg test material/kg dry soil Duration: 2 days Temp: 2 ± 2 C Moisture: 22 g water/ g dry soil Soil: silty clay loam. 'Marsillargues' ph:. (KCl) Organic carbon:.98% Half-life OA 445: more than days C accountability: 9 % % OA 445 remaining, day 2 = 8% of dose % mineralization, day 2 =.9% of dose % unextracted, day 2 = % of dose Metabolites Max (% of dose) Day no identifications, low levels Sparrow (99, ABR-92) subjected [ C-oxadiazin]thiamethoxam on a sandy loam soil to photolysis for days and determined a half-life for thiamethoxam disappearance as 54 days (2 hours photolysis/day) as compared with a dark control where the half-life was approximately 2 days. Four photolysis (and soil metabolism) products were identified on day at.5 2.4% of the dose. In a parallel study, Sparrow (99, ABR-9) subjected [ C-thiazol]thiamethoxam on the same sandy loam soil to photolysis for days and determined a half-life for thiamethoxam disappearance as approximately 45 days (2 hours photolysis/day) as compared with a dark control where the half-life was approximately 2 days. Three photolysis (and soil metabolism) products were identified at.5 2.% of the dose. Soil photolysis Ref: Sparrow, 99, ABR-92 Test material: [ C-oxadiazin]thiamethoxam Dose rate:.92 mg ai/kg Duration: days (2 hours/day) Temp: 25 C Moisture: 5% field moisture capacity Soil: sandy loam ph: 6.5 Organic matter:.9% Half-life thiamethoxam: 54 days (2 hours/day). C accountability: 9 % Dark control thiamethoxam half-life, approx 2 days % thiamethoxam remaining, day = 66% of dose Dark control, % thiamethoxam remaining, day = 8% % mineralization, day = 2.5% of dose Dark control, % mineralization, day =.% Xenon arc, 2 hours/day, 4 W/m 2 % unextracted, day =.% of dose Photolysis (and metabolism) products Max (% of dose) Day CGA % CGA % CGA 5968.% CGA 29.5% Soil photolysis Ref: Sparrow, 99, ABR-9 Test material: [ C-thiazol]thiamethoxam Dose rate:.92 mg ai/kg Duration: days (2 hours/day) Temp: 25 C Moisture: 5% field moisture capacity Soil: sandy loam ph: 6.5 Organic matter:.9% Half-life thiamethoxam: approx 45 days (2 hours/day). C accountability: 9 % Dark control thiamethoxam half-life, approx 2 days % thiamethoxam remaining, day = 59% of dose Dark control, % thiamethoxam remaining, day = 8% % mineralization, day = 2% of dose Dark control, % mineralization, day =.6% Xenon arc, 2 hours/day, 4 W/m 2 % unextracted, day = 6.8% of dose Photolysis (and metabolism) products Max (% of dose) Day CGA % CGA % CGA % Soil metabolism summary When labelled thiamethoxam was incubated in soils under aerobic conditions at 2 C, its half-life varied from 4 to days. In 8 days of incubation, the percentage of dose mineralized was approximately 2 to 2% and the percentage that became unextractable was approximately to 6%. The main soil metabolites identified were: CGA 224 (-(2-chlorothiazol-5-ylmethyl)-'- methyl-"-nitroguanidine), CGA 559 (-(2-chlorothiazol-5-ylmethyl)-5-methyl-

28 8 Thiamethoxam [,,5]oxadiazinan-4-one), CGA 5968 (-(2-chlorothiazol-5-ylmethyl)--methylurea) and CG 29 (,6-dihydro--methyl--nitro-2H-,,5-oxadiazin-4-amine). Metabolite OA 445 (-(2-chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-ylidineamine) was identified under rice paddy conditions. Cl S H H Cl S H H Cl S H H O 2 OA 4225 H CGA 224 O 2 CGA 265 H Cl Cl O Cl S rice paddy O S H OA 445 Thiamethoxam O 2 O Cl H H S S CGA 5968 O CGA 559 O O H O2 CGA 29 Figure Proposed metabolic pathway for thiamethoxam in soils. Rotational crops Information on the fate of [ C-oxadiazin]thiamethoxam and [ C-thiazol]thiamethoxam in confined crop rotational studies was made available to the meeting. Sandmeier (99, 95PSA42PR) applied [ C-oxadiazin]thiamethoxam formulated as a WG to bare ground at a rate of.2 kg ai/ha and transplanted lettuce seedlings 29 days, 9 days and 62 days after the treatment and sowed radish, 29 days, 9 days and 62 days after the treatment, spring wheat, 29, and 62 days after the treatment and winter wheat 8 days after the treatment. A parallel experiment was run with [ C-thiazol]thiamethoxam (Sandmeier, 99, 95PSA4PR). The concentrations of C radiolabel in the resulting plants and commodities are summarised in Table and the identified metabolites in Table 2 and Table. Table Confined rotational crop studies with [ C-oxadiazin]thiamethoxam and [ C- thiazol]thiamethoxam in Switzerland in 995 Application Rotational crop (variety) TSI days a THI Sample [ C-oxadiazin] days b thiamethoxam TRR, mg/kg.2 kg ai/ha equiv lettuce (Prosper) 29 c 89 heads kg ai/ha equiv lettuce 2 (Rexado) 9 d 8 heads.2..2 kg ai/ha equiv lettuce (Prosper) 62 f 425 heads kg ai/ha equiv radish (Selma 84) 29 c 89 tops roots kg ai/ha equiv radish 2 (Radis Rex) 9 d 8 tops roots kg ai/ha equiv radish (Selma 84) 62 f 425 tops roots.8.2 [ C-thiazol] thiamethoxam TRR, mg/kg.9.

29 Thiamethoxam 85 Application Rotational crop (variety).2 kg ai/ha equiv spring wheat (Lona).2 kg ai/ha equiv spring wheat 2 (Lona).2 kg ai/ha equiv spring wheat (Lona).2 kg ai/ha equiv winter wheat (Galaxie) TSI days a 29 c f e THI Sample [ C-oxadiazin] days b thiamethoxam TRR, mg/kg whole tops straw husks grain whole tops straw husks grain whole tops straw husks grain whole tops whole tops straw husks grain a TSI: interval between treatment on soil and sowing of rotation crop, days [ C-thiazol] thiamethoxam TRR, mg/kg b THI: interval between treatment on soil and harvest of rotation crop (or sampling of soil), days c Day 29. Oxadiazin label: Soil ( cm) TRR =.5 mg/kg. Soil thiamethoxam =. mg/kg. Thiazol label: Soil (- cm) TRR =. mg/kg. Soil thiamethoxam =. mg/kg d Day 9. Oxadiazin label: Soil ( cm) TRR =..9 mg/kg. Soil thiamethoxam =. mg/kg Thiazol label: Soil ( cm) TRR =.86 mg/kg. Soil thiamethoxam =.42 mg/kg e Day 8. Oxadiazin label: Soil ( cm) TRR =.4 mg/kg. Soil thiamethoxam =. mg/kg Thiazol label: Soil ( cm) TRR =.55 mg/kg. Soil thiamethoxam =.2 mg/kg f Day 62. Oxadiazin label: Soil ( cm) TRR =.5 mg/kg. Soil thiamethoxam =.8 mg/kg Thiazol label: Soil ( cm) TRR =.4 mg/kg. Soil thiamethoxam =.6 mg/kg For the [ C-oxadiazin] label (Sandmeier, 99, 95PSA42PR, Table ), parent thiamethoxam was the major identified component in lettuce, but the residue levels were very low,.85 and.5 mg/kg. Thiamethoxam (.9 mg/kg) and CGA 224 (.2 mg/kg) were the major identified residues in radish tops from radish sown 29 days after the bare ground treatment. Residues in wheat grain were very low. The TRR was higher in wheat straw than in other wheat commodities and CGA 829, OA 4225, OA 452 and CGA 265 were the main identified metabolites. CGA 265 and CGA 224 were apparently the most persistent residues, identifiable, but at very low levels, in wheat straw from wheat sown 8 and 62 days after the bare ground treatment. Table 2 Identified components of the residue found in the rotational crop after a bare ground treatment with [ C-oxadiazin]thiamethoxam at.2 kg ai/ha See also Table Sample Residues, expressed as parent thiamethoxam, mg/kg TRR a E b thiamethoxam OA CGA OA OA CGA Metab CGA U 224 Lettuce, heads Lettuce 2, heads lettuce, heads.8 Radish, tops roots.5 Radish 2, tops..... roots.2 Radish, tops roots.8.2 Spring wheat, tops straw husks grain c c Spring wheat 2, tops

30 86 Thiamethoxam Sample straw husks grain Spring wheat, tops straw husks grain Winter wheat, tops tops straw husks grain Residues, expressed as parent thiamethoxam, mg/kg TRR a E b thiamethoxam OA CGA OA a TRR: total radioactive residues..4.2 OA c.2 CGA Metab 4U..2.8 CGA b E: not extracted. c Major identified components of the residue For the [ C-thiazol] label (Sandmeier, 99, 95PSA4PR, Table ), parent thiamethoxam was also the major identified component in lettuce, but the residue levels were also very low,.5 and.24 mg/kg. Thiamethoxam (.2 mg/kg) and CGA 265 (. mg/kg) were the major identified residues in radish tops from radish sown 29 days after the bare ground treatment. Residues in wheat grain were very low. The TRR was generally higher in wheat straw than in other wheat commodities and OA 4225, CGA 265 and CGA 224 were the main identified metabolites. CGA 265 and CGA 224 were apparently the most persistent residues, identifiable, but at very low levels, in wheat straw from wheat sown 8 and 62 days after the bare ground treatment. Table Identified components of the residue found in the rotational crop after a bare ground treatment with [ C-thiazol]thiamethoxam at.2 kg ai/ha See also Table Sample Residues, expressed as parent thiamethoxam, mg/kg TRR a E b thiamethoxam OA 445 OA 4225 CGA 265 Metab 4U CGA 224 Lettuce, heads Lettuce 2, heads lettuce, heads.4 Radish, tops roots. Radish 2, tops roots..2 Radish, tops roots.9. Spring wheat, tops straw husks grain Spring wheat 2, tops straw husks grain Spring wheat, tops straw husks grain Winter wheat, tops tops straw husks grain a TRR: total radioactive residues. b E: not extracted c c c

31 Thiamethoxam 8 c Major identified components of the residue Summary of rotational crops When lettuce, radish and wheat were grown in a rotational crop situation 29, 9 and 62 days after treatment of bare ground with labelled thiamethoxam, TRR levels were generally low:.5 mg/kg and below for lettuce;.2 mg/kg and below for radish tops;. mg/kg and below for radish roots and.5 mg/kg and below for wheat grain. Higher TRR levels were found in wheat straw:.5.5 mg/kg. Parent thiamethoxam was the most commonly detected component of the residue and was present at higher concentrations (up to.2 mg/kg) than other components in lettuce and radish. In wheat straw and grain, parent thiamethoxam and metabolite CGA 224 (-(2-chlorothiazol-5- ylmethyl)-'-methyl-"-nitroguanidine) were the most commonly detected. However, in some cases other metabolites were present at higher levels: CGA 265 (-(2-chlorothiazol-5-ylmethyl)-'- nitroguanidine) in wheat grain and -methylguanidine (CGA 829), OA 452 (-nitro-'- methylguanidine), OA 4225 (-(2-chlorothiazol-5-ylmethyl)-'-methyl-guanidine) and CGA 265 (-(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine) in wheat straw. Residues of parent thiamethoxam and some metabolites could occur in rotational crops, but generally at very low levels. Detections would be unlikely except for residues in commodities such as wheat straw. METHODS OF RESIDUE AALYSIS Analytical methods The Meeting received descriptions and validation data for analytical methods for residues of thiamethoxam and CGA 224 in animal and plant matrices. Residues of parent thiamethoxam and metabolite CGA 224 in plant and animal matrices may be analysed by HPLC-MS or HPLC-UV with an LOQ of. mg/kg after a series of cleanup steps. A microwave extraction procedure is necessary for good extraction of residues from some animal commodities. Thiamethoxam, CGA 224 and CGA 265 (-(2-chlorothiazol-5- ylmethyl)-'-nitroguanidine) were not suitable analytes for the multiresidue methods tested. Animal commodities Bovine and avian liver (Lin, 22, 26-9) Analyte: thiamethoxam, CGA 224 HPLC-MS Method AG-65 microwave extraction LOQ:. mg/kg. Description A portion of liver sample is ground with acetonitrile-water in a homogenizer and the extract is filtered through a filter paper. The filter paper and filter cake are then transferred to a microwave extraction vessel and are subject to further extraction with acetonitrile. During one hour, the extraction mixture is taken through a temperature program up to 5 ºC before filtration through a filter paper. An aliquot is cleaned up by liquid-liquid partition with hexane. Further cleanup is effected on cartridge columns ready for HPLC-MS analysis. See below for further description of the AG-65 procedure. Lin (22, 26 9 and 858 ) showed that, in testing method AG-65, the microwave assisted extraction of avian and bovine livers from metabolism samples increased the extractability of C from approximately 5% extracted to approximately 8% extracted. Campbell (998, 46) analysed samples from the metabolism studies using method AG- 65. The results are compared in Table 5. Where the concentrations are low, i.e. below approximately.5 mg/kg, it is difficult to draw conclusions because of the uncertainties in the data being compared (from different laboratories at different times). For pears and cucumbers, the analytical method concentration of thiamethoxam was approximately 4 9% of the metabolism

32 88 Thiamethoxam value. For thiamethoxam in goat meat, the analytical method result was 56 9% of the metabolism result. But the thiamethoxam concentration in goat milk, measured by method AG-65 was only about 2% of the value from the metabolism study. However, the data are from different laboratories on samples with different storage histories, making interpretation difficult; the metabolism analysis took place in a Swiss laboratory in September 99 and the AG-65 analysis was in April 998 in a US laboratory. Method AG-65 was subject to a laboratory validation for residue analysis of thiamethoxam and CGA 224 residues in milk, eggs, meat, kidney and liver (Boxwell C, 24, RJ5B). An LOQ of. mg/kg was demonstrated for eggs, meat, liver and kidney and an LOQ of.5 mg/kg was shown for milk. The microwave extraction step was included for the liver analyses. Recovery data with both the HPLC-UV finish and the confirmatory LC-MS/MS finish are recorded in Table. Linearity and proportionality of response were demonstrated for thiamethoxam and CGA 224 with both HPLC-UV and HPLC-MS/MS over a 5 8 times concentration range. Enhancement and suppression effects for MS/MS detection were small. Method AG-65 was subject to an independent laboratory validation for residue analysis of thiamethoxam and CGA 224 residues in eggs (Bell, 25, CEMR-265). An LOQ of. mg/kg was demonstrated for eggs. Recovery data with both the HPLC-UV finish and the LC-MS finish are recorded in Table. Initial analyses produced variable recoveries for both thiamethoxam and CGA 224. A minor modification to an evaporation step overcame the problem heating block set at 4 ºC and a gentle stream of nitrogen for evaporation. Method AG-65 was also subject to an independent laboratory validation for residue analysis of thiamethoxam and CGA 224 residues in milk and bovine muscle and liver (Rawle, 24, CEMR-2). An LOQ of.5 mg/kg was demonstrated for milk and. mg/kg for muscle and liver. Recovery data with both the HPLC-UV finish and the LC-MS finish are recorded in Table. The method for liver included the microwave extraction step. Analysis of residues in liver was not possible with the HPLC-UV finish because of too many interfering peaks, but was successful with the LC-MS/MS finish. Plant commodities Plant material (Mair, 995, REM 9.) Analyte: thiamethoxam HPLC-UV Method REM 9. LOQ:.2 mg/kg. Description A representative sample is homogenized or shaken with water + methanol (8 + 2 by volume). The extract, after filtration through Celite, is diluted with water and cleaned up on a phenyl-phase extraction cartridge and a graphitised non-porous carbon cartridge. The eluate (water + tetrahydrofuran) is evaporated to leave a concentrated water phase which is diluted with water ready for reversed-phase HPLC analysis with UV detection at 255 nm. Plant material (Mair, 998, REM 9.) Analytes: thiamethoxam, CGA 224 HPLC-UV Method REM 9. LOQ:.2 mg/kg,.5 mg/kg for cereal straw, cotton hulls. Description A representative homogenized sample is extracted with water + methanol ( + by volume). The extract, after filtration through Celite, is diluted with water and cleaned up on a phenyl-phase extraction cartridge and a graphitised non-porous carbon cartridge. The eluate is evaporated to leave a concentrated water phase which is diluted with water ready for reversed-phase HPLC analysis with UV detection at 255 nm (thiamethoxam) and 2 nm (CGA 224). For fatty or oily crops, samples are extracted with pure acetonitrile in place of the water + methanol and the acetonitrile phase is washed with hexane, which is discarded, in the first clean-up step. Confirmatory analysis: LC-MS-MS Animal and crop substrates (Campbell, 998, 46) Analytes: thiamethoxam, CGA 224 HPLC-UV, HPLC-MS Method AG-65 LOQ:. mg/kg for most substrates,.5 mg/kg for milk and fruit juices. Description Samples are extracted by homogenization in acetonitrile + water (8 + 2). Liquid samples, e.g. eggs, milk, juices, are extracted by shaking with acetonitrile + water (8 + 2). An aliquot of the extract is evaporated until only an aqueous phase remains and the residues are subject to cleanup on a phenyl

33 Thiamethoxam 89 cartridge and then partition into ethyl acetate. Further cleanup is effected on an amino cartridge column and an alumina cartridge column. The eluate is then evaporated and the residues taken up in mobile phase (hexane + ethyl acetate + isopropanol + methanol) for normal phase HPLC-UV analysis. Confirmation analysis is possible by reversed phase HPLC-MS. Cotton, forages and fodders require an extra cleanup step with an anion exchange SPE column immediately after the extraction. Lettuce, tomato, grape, tobacco (Crook, 24, REM 9.6) Analytes: thiamethoxam, CGA 224 LC-MS/MS Method REM 9.6 LOQ:.2 mg/kg. Description Samples are homogenized with water + methanol (5 + 5 by volume), but with adjustment of water volume for water content of sample. After the mixture is centrifuged, the supernatant liquid from lettuce and tomato samples may be taken, without cleanup, for dilution and LC-MS/MS analysis. The supernatant liquids from grape and tobacco samples are cleaned up on suitable cartridges, with residues eluting in acetonitrile. After the solvent is evaporated, the residues are taken up in acetonitrile + water for LC-MS/MS analysis. Protonated molecular ions (thiamethoxam m/z 292 and CGA 224 m/z 25) are selected for fragmentation and produce the most abundant ions 2. and 69., respectively, for quantitative analysis. Tea leaves (Kato and Odanaka, 998, -ov-998) Analytes: thiamethoxam, CGA 224 HPLC-UV LOQ:.5 mg/kg. Description Tea leaves are swollen by added water for 2 hours and are then extracted with acetone. The extract is cleaned up on a porous diatomite column, a cation exchange column and an alumina column. The cleaned up extract is then analysed by HPLC-UV. Pears from the metabolism study were extracted and analysed by method REM 9. for comparison with the C measurements (Tribolet, 998, /98). The pear specimen was from the [ C-oxadiazin]thiamethoxam treatment (Capps, 998, ABR-984). By combustion, the TRR content was.68 mg/kg, expressed as thiamethoxam equivalents. Extractability by method REM 9. of C was 9% and 8% for shaking and maceration respectively. Measured concentrations of thiamethoxam in the pear were.96,. and. mg/kg for the original metabolism study, by radiolabel analysis on the LC fraction and by HPLC-UV respectively. Similarly, measured concentrations of CGA 224 (expressed as thiamethoxam) were.4,.85 and.5 mg/kg for the same three situations. Method REM 9. was subject to an independent laboratory validation for residue analysis of tomatoes and wheat grain (Rawle, 24, CEMR-22). Recovery data with both the HPLC-UV finish and the confirmatory LC-MS/MS finish are recorded in Table. Initially, recoveries were low on wheat grain and interfering peaks occurred in the HPLC-UV trace. A minor modification corrected the problem dilution of an aliquot of extract with 2 ml water instead of ml before the first solidphase cartridge cleanup. Quantitative analyses by the confirmatory LC-MS finish were generally in good agreement with those of the HPLC-UV finish for method AG-65 (Campbell, 998, 46) with highest relative deviations with concentrations near LOQ. Recovery data are included in Table. Analytical method AG-65 was successfully subjected to independent laboratory validation (Tauber and McLean, 999, 65-99) with recovery testing of thiamethoxam and CGA 224 from a grass sample. Recovery testing data are included in Table. Analytical method AG-65 was successfully subjected to independent laboratory validation (Crawford, 998, 49-98) with recovery testing of thiamethoxam and CGA 224 from samples of milk, eggs, bovine liver, tomatoes, apple wet pomace, lettuce, wheat grain, wheat straw, wheat forage and cotton seed 9. The first test of the method was successful for all samples except eggs, where 9 Crawford, 998, ILV of method In this study, recoveries at low concentrations cannot be used because the analytical data are apparently rounded before the recovery is calculated. For example, recoveries from milk at.5 and.2 mg mg/kg are all exactly %.

34 82 Thiamethoxam bumping and foaming during an evaporation step resulted in loss of residues. The second attempt with eggs was successful after minor method modifications taking a smaller aliquot and adjusting solvent volumes. Recovery testing data are included in Table. Table Analytical recoveries for spiked thiamethoxam and CGA 224 in various substrates. Commodity Spiked Spike conc, n Mean Range Method Ref compound mg/kg recov% recov% Apple thiamethoxam.2 86% 9 92% REM 9. HPLC-UV 5/98 Apple thiamethoxam.2 88% 84 9% REM 9. HPLC-UV 5/98 Apple CGA % 8 92% REM 9. HPLC-UV 5/98 Apple CGA % 9% REM 9. HPLC-UV 5/98 Apple thiamethoxam % 84 9% REM 9. REM 9. Apple juice thiamethoxam % 82 89% AG-65 HPLC-UV 46 Apple juice CGA % 88% AG-65 HPLC-UV 46 Apple pomace thiamethoxam.2 2 8, 9% AG Apple pomace CGA , 9% AG Apple wet pomace thiamethoxam.. 4 % 69 6% AG-65 HPLC-UV 46 Apple wet pomace CGA % 8% AG-65 HPLC-UV 46 Avian liver thiamethoxam.. 2 % 2% AG-65-microwave 26 9 Avian liver CGA % 82 % AG-65-microwave 26 9 Barley grain thiamethoxam.2 8% 9 96% REM 9. HPLC-UV 5/98 Barley grain thiamethoxam.2 8% 82 92% REM 9. HPLC-UV 5/98 Barley grain CGA % 8% REM 9. HPLC-UV 5/98 Barley grain CGA % 8% REM 9. HPLC-UV 5/98 Barley straw thiamethoxam.5 % 65 % REM 9. HPLC-UV 5/98 Barley straw thiamethoxam.5 6% 84% REM 9. HPLC-UV 5/98 Barley straw CGA % 86 89% REM 9. HPLC-UV 5/98 Barley straw CGA % 68 86% REM 9. HPLC-UV 5/98 Bovine liver thiamethoxam % 8 9% AG-65-microwave 26 9 Bovine liver CGA % 82 2% AG-65-microwave 26 9 Bovine liver thiamethoxam.. 98% 6 5% AG-65 LC-MS c CEMR-2 Bovine liver CGA % 5 8% AG-65 LC-MS c CEMR-2 Bovine muscle thiamethoxam.. 92% % AG-65 LC-UV CEMR-2 Bovine muscle thiamethoxam.. 85% 9 9% AG-65 LC-MS CEMR-2 Bovine muscle CGA % 86 % AG-65 LC-UV CEMR-2 Bovine muscle CGA % 9 % AG-65 LC-MS CEMR-2 Broccoli thiamethoxam % 6 % AG-65 HPLC-UV 46 Broccoli CGA % 82 95% AG-65 HPLC-UV 46 Cabbage thiamethoxam % 88 % REM 9. REM 9. Cotton hulls thiamethoxam.5 9% 8 96% REM 9. HPLC-UV 5/98 Cotton hulls thiamethoxam.5 9% 89 94% REM 9. HPLC-UV 5/98 Cotton hulls CGA % 86 99% REM 9. HPLC-UV 5/98 Cotton hulls CGA % 9 96% REM 9. HPLC-UV 5/98 Cotton seed thiamethoxam % 58 4% AG-65 LC-MS 46 Cotton seed CGA % 89% AG-65 LC-MS 46 Cotton seed thiamethoxam. 2, % AG Cotton seed CGA , 99% AG Cotton seed thiamethoxam.2 8% 85% REM 9. HPLC-UV 5/98 Cotton seed thiamethoxam.2 8% 88% REM 9. HPLC-UV 5/98 Cotton seed CGA % 8 85% REM 9. HPLC-UV 5/98 Cotton seed CGA % 8 88% REM 9. HPLC-UV 5/98 Cotton seed oil thiamethoxam % 6 % AG-65 HPLC-UV 46 Cotton seed oil CGA % 6 8% AG-65 HPLC-UV 46 Cucumber thiamethoxam..5 8% 8 9% AG-65 HPLC-UV 46 Cucumber CGA % 9, 92% AG-65 HPLC-UV 46 Cucumber thiamethoxam.2 2 8% 86, 88% REM 9. HPLC-UV 5/98 Cucumber thiamethoxam.2 2 9% 8, 96% REM 9. HPLC-UV 5/98 Cucumber CGA % 84, 94% REM 9. HPLC-UV 5/98 Cucumber CGA % 4, 92% REM 9. HPLC-UV 5/98 Eggs thiamethoxam % 8 92% AG-65 HPLC-UV 46 Eggs CGA % 85 95% AG-65 HPLC-UV 46

35 Thiamethoxam 82 Commodity Spiked Spike conc, n Mean Range Method Ref compound mg/kg recov% recov% Eggs thiamethoxam. 2 95, 92% AG Eggs CGA , 9% AG Eggs thiamethoxam.. 8% 8 9% AG-65 HPLC-UV CEMR-265 Eggs thiamethoxam.. 9% 4 % AG-65 LC-MS CEMR-265 Eggs CGA % 84 98% AG-65 HPLC-UV CEMR-265 Eggs CGA % 69 8% AG-65 LC-MS CEMR-265 Eggs thiamethoxam.. 8% 4 88% AG-65 HPLC-UV RJ5B Eggs thiamethoxam.. 8% 2 88% AG-65 HPLC-MS/MS RJ5B Eggs CGA % 8 % AG-65 HPLC-UV RJ5B Eggs CGA % 85% AG-65 HPLC-MS/MS RJ5B Fat, bovine thiamethoxam % 9 86% AG-65 HPLC-UV 46 Fat, bovine CGA % 85 9% AG-65 HPLC-UV 46 Fat, poultry thiamethoxam % 8 98% AG-65 HPLC-UV 46 Fat, poultry CGA % 89 94% AG-65 HPLC-UV 46 Grapes b thiamethoxam.2.2 8% 9% REM 9.6 REM 9.6 Grapes b CGA % 8 6% REM 9.6 REM 9.6 Grass thiamethoxam % % AG-65 LC-MS/MS Grass CGA % 2 % AG-65 LC-MS/MS Kidney thiamethoxam.. 92% 8 9% AG-65 HPLC-UV RJ5B Kidney thiamethoxam.. 95% 92 2% AG-65 HPLC-MS/MS RJ5B Kidney CGA % 85 % AG-65 HPLC-UV RJ5B Kidney CGA % 9 8% AG-65 HPLC-MS/MS RJ5B Kidney, bovine thiamethoxam % 8 9% AG-65 HPLC-UV 46 Kidney, bovine CGA % 8 94% AG-65 HPLC-UV 46 Lettuce thiamethoxam 2. 2, 92% AG Lettuce CGA , 94% AG Lettuce thiamethoxam.2 9% 82 94% REM 9. HPLC-UV 5/98 Lettuce thiamethoxam.2 9% 88 96% REM 9. HPLC-UV 5/98 Lettuce CGA % 6 9% REM 9. HPLC-UV 5/98 Lettuce CGA % 8 85% REM 9. HPLC-UV 5/98 Lettuce thiamethoxam % 82 9% REM 9.6 REM 9.6 Lettuce CGA % % REM 9.6 REM 9.6 Liver thiamethoxam.. 82% 6 6% AG-65 HPLC-MS/MS c RJ5B Liver CGA % 2 5% AG-65 HPLC-MS/MS c RJ5B Liver, bovine thiamethoxam % 84 9% AG-65 HPLC-UV 46 Liver, bovine CGA % 86 92% AG-65 HPLC-UV 46 Liver, bovine thiamethoxam. 2 88, 8% AG Liver, bovine CGA , 92% AG Maize grain thiamethoxam % 8 2% REM 9. REM 9. Maize plant thiamethoxam % 98% REM 9. REM 9. Meat thiamethoxam.. 9% 4 6% AG-65 HPLC-UV RJ5B Meat thiamethoxam.. 92% 5% AG-65 HPLC-MS/MS RJ5B Meat CGA % 8 % AG-65 HPLC-UV RJ5B Meat CGA % 9 9% AG-65 HPLC-MS/MS RJ5B Milk thiamethoxam % 9 99% AG-65 LC-UV CEMR-2 Milk thiamethoxam % 85 9% AG-65 LC-MS CEMR-2 Milk CGA % 68 86% AG-65 LC-UV CEMR-2 Milk CGA % 8 98% AG-65 LC-MS CEMR-2 Milk thiamethoxam % 9 % AG-65 HPLC-UV RJ5B Milk thiamethoxam % 9 9% AG-65 HPLC-MS/MS RJ5B Milk CGA % 8 % AG-65 HPLC-UV RJ5B Milk CGA % 84 % AG-65 HPLC-MS/MS RJ5B Milk, goat thiamethoxam.5.5 2% 88 % AG-65 HPLC-UV 46 Milk, goat CGA % 9 96% AG-65 HPLC-UV 46 Muscle, goat thiamethoxam.. 8% 86 88% AG-65 HPLC-UV 46 Muscle, goat CGA % 88 89% AG-65 HPLC-UV 46 Oilseed rape thiamethoxam.2 5 % 6 89% REM 9. HPLC-UV RJ59B Oilseed rape thiamethoxam % 85 9% REM 9. LC-MS/MS RJ59B Oilseed rape thiamethoxam.2 5 9% 5 8% REM 9. HPLC-UV RJ59B Oilseed rape thiamethoxam % 82 88% REM 9. LC-MS/MS RJ59B

36 822 Thiamethoxam Commodity Spiked Spike conc, n Mean Range Method Ref compound mg/kg recov% recov% Oilseed rape CGA % 6 9% REM 9. HPLC-UV RJ59B Oilseed rape CGA % 9 85% REM 9. LC-MS/MS RJ59B Oilseed rape CGA % 8% REM 9. HPLC-UV RJ59B Oilseed rape CGA % 9 8% REM 9. LC-MS/MS RJ59B Orange thiamethoxam.2 5 8% 8 98% REM 9. HPLC-UV RJ59B Orange thiamethoxam.2 5 9% 92 2% REM 9. LC-MS/MS RJ59B Orange thiamethoxam.2 5 8% 84 9% REM 9. HPLC-UV RJ59B Orange thiamethoxam % 9 96% REM 9. LC-MS/MS RJ59B Orange CGA % 6 % REM 9. HPLC-UV RJ59B Orange CGA % 8 95% REM 9. LC-MS/MS RJ59B Orange CGA % 84 92% REM 9. HPLC-UV RJ59B Orange CGA % 9 95% REM 9. LC-MS/MS RJ59B Peach thiamethoxam % 84, 94% REM 9. HPLC-UV 5/98 Peach thiamethoxam.2 2 8%, 8% REM 9. HPLC-UV 5/98 Peach CGA % 9, 82% REM 9. HPLC-UV 5/98 Peach CGA % 6, 9% REM 9. HPLC-UV 5/98 Pears thiamethoxam % 85 % AG-65 HPLC-UV 46 Pears CGA % 88 8% AG-65 HPLC-UV 46 Peas, empty pods thiamethoxam % 82 9% REM 9. REM 9. Peas, seeds thiamethoxam.2 8% 88% REM 9. HPLC-UV 5/98 Peas, seeds thiamethoxam.2 8% 82% REM 9. HPLC-UV 5/98 Peas, seeds CGA % 86% REM 9. HPLC-UV 5/98 Peas, seeds CGA % 68 82% REM 9. HPLC-UV 5/98 Peas, seeds thiamethoxam % 82 % REM 9. REM 9. Peppers, green thiamethoxam % 85 95% AG-65 HPLC-UV 46 Peppers, green CGA % 86 92% AG-65 HPLC-UV 46 Peppers, sweet thiamethoxam.2 96% 9 % REM 9. HPLC-UV 5/98 Peppers, sweet thiamethoxam.2 96% 94 99% REM 9. HPLC-UV 5/98 Peppers, sweet CGA % 62 2% REM 9. HPLC-UV 5/98 Peppers, sweet CGA % 6 9% REM 9. HPLC-UV 5/98 Potato tubers thiamethoxam % 8 96% AG-65 HPLC-UV 46 Potato tubers CGA % 89 % AG-65 HPLC-UV 46 Potato tubers thiamethoxam % 82 99% REM 9. REM 9. Sorghum, forage thiamethoxam.. 4 8% 68 86% AG-65 LC-MS 46 Sorghum, forage CGA % 8 96% AG-65 LC-MS 46 Spinach thiamethoxam % 9 % AG-65 HPLC-UV 46 Spinach CGA % 9 % AG-65 HPLC-UV 46 Sugar beet leaves thiamethoxam % 9 % REM 9. REM 9. Sugar beet roots thiamethoxam % 8 86% REM 9. REM 9. Sunflower seed thiamethoxam % 89, % REM 9. HPLC-UV 5/98 Sunflower seed thiamethoxam.2 2 9% 8, 8% REM 9. HPLC-UV 5/98 Sunflower seed CGA % 4, 86% REM 9. HPLC-UV 5/98 Sunflower seed CGA %, 84% REM 9. HPLC-UV 5/98 Tomato thiamethoxam % 68 % AG-65 HPLC-UV 46 Tomato CGA % 9 5% AG-65 HPLC-UV 46 Tomato thiamethoxam. 2, 82' AG Tomato CGA , 8% AG Tomato thiamethoxam % 4 % REM 9. HPLC-UV 5/98 Tomato thiamethoxam.2 9% 8 6% REM 9. HPLC-UV 5/98 Tomato thiamethoxam.2 5 9% 8 % REM 9. HPLC-UV 5/98 Tomato thiamethoxam.2 94% 9 2% REM 9. HPLC-UV 5/98 Tomato CGA % 6 2% REM 9. HPLC-UV 5/98 Tomato CGA % 82 8% REM 9. HPLC-UV 5/98 Tomato CGA % 8 9% REM 9. HPLC-UV 5/98 Tomato CGA % 69 99% REM 9. HPLC-UV 5/98 Tomato thiamethoxam.2 5 % 85 % a REM 9. HPLC-UV CEMR-22 Tomato thiamethoxam.2 5 8% 8 95% a REM 9. LC-MS/MS CEMR-22 Tomato thiamethoxam % 85 2% REM 9. HPLC-UV CEMR-22 Tomato thiamethoxam.2 5 9% 8 95% REM 9. LC-MS/MS CEMR-22 Tomato CGA % 4 8% a REM 9. HPLC-UV CEMR-22

37 Thiamethoxam 82 Commodity Spiked Spike conc, n Mean Range Method Ref compound mg/kg recov% recov% Tomato CGA % 95% a REM 9. LC-MS/MS CEMR-22 Tomato CGA % 6 9% REM 9. HPLC-UV CEMR-22 Tomato CGA % 9% REM 9. LC-MS/MS CEMR-22 Tomato thiamethoxam % 82 9% REM 9. REM 9. Tomato thiamethoxam.2.2 8% 2 % REM 9.6 REM 9.6 Tomato CGA % 8 2% REM 9.6 REM 9.6 Tomato thiamethoxam % 82 % REM 9. HPLC-UV RJ59B Tomato thiamethoxam.2 5 % 99 % REM 9. LC-MS/MS RJ59B Tomato thiamethoxam % 86 9% REM 9. HPLC-UV RJ59B Tomato thiamethoxam % 9 9% REM 9. LC-MS/MS RJ59B Tomato CGA % 9% REM 9. HPLC-UV RJ59B Tomato CGA % 85 9% REM 9. LC-MS/MS RJ59B Tomato CGA % 84 95% REM 9. HPLC-UV RJ59B Tomato CGA % 85 92% REM 9. LC-MS/MS RJ59B Tomato paste thiamethoxam % 9% AG-65 HPLC-UV 46 Tomato paste CGA % 84% AG-65 HPLC-UV 46 Wheat forage thiamethoxam. 2 85, 82% AG Wheat forage CGA , 84% AG Wheat grain thiamethoxam % 8 2% AG-65 HPLC-UV 46 Wheat grain CGA % 8 94% AG-65 HPLC-UV 46 Wheat grain thiamethoxam. 2 94, 94% AG Wheat grain CGA , 9% AG Wheat grain thiamethoxam.2 5% 82% REM 9. HPLC-UV 5/98 Wheat grain thiamethoxam.2 9% 5 82% REM 9. HPLC-UV 5/98 Wheat grain CGA % 68 84% REM 9. HPLC-UV 5/98 Wheat grain CGA % 68 % REM 9. HPLC-UV 5/98 Wheat grain thiamethoxam.2 5 9% 85% REM 9. HPLC-UV CEMR-22 Wheat grain thiamethoxam.2 5 8% 8 86% REM 9. LC-MS/MS CEMR-22 Wheat grain thiamethoxam.2 5 9% 5 85% REM 9. HPLC-UV CEMR-22 Wheat grain thiamethoxam.2 5 9% 4 84% REM 9. LC-MS/MS CEMR-22 Wheat grain CGA % 89% REM 9. HPLC-UV CEMR-22 Wheat grain CGA % 8 82% REM 9. LC-MS/MS CEMR-22 Wheat grain CGA % 5 8% REM 9. HPLC-UV CEMR-22 Wheat grain CGA % 8 8% REM 9. LC-MS/MS CEMR-22 Wheat grain thiamethoxam.2 5 2% 65 % REM 9. HPLC-UV RJ59B Wheat grain thiamethoxam % 86 9% REM 9. LC-MS/MS RJ59B Wheat grain thiamethoxam.2 5 % 5 9% REM 9. HPLC-UV RJ59B Wheat grain thiamethoxam.2 5 8% 8 85% REM 9. LC-MS/MS RJ59B Wheat grain CGA % 8 92% REM 9. HPLC-UV RJ59B Wheat grain CGA % 82% REM 9. LC-MS/MS RJ59B Wheat grain CGA % 5 85% REM 9. HPLC-UV RJ59B Wheat grain CGA % 6 8% REM 9. LC-MS/MS RJ59B Wheat straw thiamethoxam. 2 88, 88% AG Wheat straw CGA , 94% AG Wheat straw thiamethoxam.5 % 6 9% REM 9. HPLC-UV 5/98 Wheat straw thiamethoxam.5 8% 86% REM 9. HPLC-UV 5/98 Wheat straw CGA % 55 85% REM 9. HPLC-UV 5/98 Wheat straw CGA % 66 4% REM 9. HPLC-UV 5/98 a CEMR-22. One analytical run produced recoveries of 26-26%, probably contamination, and was not included in the calculated mean. b Grapes validation data without including SPE cartridge cleanup. c Microwave assisted extraction.

38 824 Thiamethoxam Table 5 Comparison of method AG-65 analytical results with concentrations of thiamethoxam and CGA 224 measured during the C metabolism studies (Campbell, 998, 46). Substrate Metabolism ref Thiamethoxam, mg/kg CGA 224, mg/kg a Metabolism analysis AG-65 analysis b Metabolism analysis AG-65 analysis b Pear ABR-984, (.).8.9 Maize grain c 95PSA4PR2, 9/9.6. (.6) Maize fodder 95PSA4PR2, 9/ (.29).2.2 Cucumber ABR-9848, (.) Cucumber ABR-9848, (.4)..2 Goat meat 2AM (.).4.6 Goat milk 2AM (.44).2. a Residue concentrations of CGA 224 in the metabolism studies are expressed as parent compound. Expression as CGA 224 is shown in parentheses (MW correction of.86). b Samples were analysed in triplicate. The range is reported. c Crook, 998, 46. Table VI. Sample identification numbers in the metabolism study were not provided for corn grain and corn fodder. Supplementary information was provided by the company to link the samples from the metabolism studies with the analyses by method AG-65. Walser (99, 5/9) examined multiresidue DFG Method S 9 for the analysis of thiamethoxam and CGA 224 residues in potatoes, wheat grain and rapeseed. DFG Method S 9 was suitable for the analysis of thiamethoxam residues in wheat grain and potatoes. It was not suitable for the analysis of thiamethoxam residues in rapeseed or for the analysis of CGA 224 residues in any substrate. Too many interfering peaks occurred in the chromatograms from rapeseed samples. The GC peak of CGA 224 shows strong tailing and is not suitable for quantitative analysis. Pelz and Steinhauer (2, SY-V) tested an extended revision of Method DFG S 9 for the analysis of thiamethoxam residues in rapeseed and concluded that reliable determination of thiamethoxam residues at.2.2 mg/kg could not be achieved with sufficient accuracy. The method is not applicable to the determination of thiamethoxam residues in rapeseed. Lin (998, ABR-9854) examined the applicability of the FDA multiresidue methods (FDA Pesticide Analytical Manual, Volume I) for the analysis of residues of thiamethoxam, CGA 224 and CGA 265 in foods and animal feeds. Thiamethoxam provided adequate detector responses in the GLC systems and it was partially recovered in the method without cleanup. However, it was not recovered from the cleanup columns. CGA 224 and CGA 265 did not produce adequate detector responses to any of the multiresidue method systems. Thiamethoxam, CGA 224 and CGA 265 are not suitable analytes for the multiresidue methods tested. Stability of residues in stored analytical samples Information was received on the freezer storage stability of thiamethoxam and metabolite CGA 224 at residue concentrations expected in apples, tomatoes, potatoes tubers, rape seed, maize grain, cranberries, hops, barley grain, barley hay, barley straw, pearled barley and barley flour. For the animal commodities, beef, liver, milk and eggs, freezer storage stability data were available for thiamethoxam and two metabolites CGA 224 and CGA 265. Maier (998, 2/96) tested the freezer storage stability of thiamethoxam residues in homogenized samples in a freezer below approximately 8 ºC for two years. The residues in apples were incurred residues from a field trial. Other homogenized commodities were spread in a thin layer and sprayed with a thiamethoxam solution to produce suitable residue levels for the tests. The analyses were validated with procedural recoveries at each testing interval (Table 6).

39 Thiamethoxam 825 Table 6 Freezer storage stability data for thiamethoxam in plant matrices. Residues are unadjusted for analytical recoveries. The residues in apples were incurred residues. Other homogenized commodities were sprayed with a thiamethoxam solution. Storage interval, days Procedural recov % thiamethoxam, mg/kg Storage interval, days APPLES, with incurred residues from a field residue trial, were homogenized and stored in polyethylene containers below approx 8 C (Maier, 998, 2/96). Procedural recov % thiamethoxam, mg/kg TOMATOES were homogenized and sprayed with thiamethoxam and stored in polyethylene containers below approx 8 C (Maier, 998, 2/96). 8% 94% % 94% % 88% % 86% % 9% % 8% % % % 8% % 82% % 92% % 94% % 5% residues apparently stable residues apparently stable POTATO TUBERS were homogenized and sprayed with thiamethoxam and stored in polyethylene containers below approx 8 C (Maier, 998, 2/96). RAPE SEED was homogenized and sprayed with thiamethoxam and stored in polyethylene containers below approx 8 C (Maier, 998, 2/96). 86% 95% % 9% % 8% % 8% % 85% % 89% % 82% % % % 8% % 68% % 9% % 9%.2.2. residues apparently stable residues apparently stable MAIZE GRAI was homogenized and sprayed with thiamethoxam and stored in polyethylene containers below approx 8 C (Maier, 998, 2/96). 4% 8% % 6% % 86% % % % 8% % 8% residues apparently stable Hohl (999, 2/9) tested the freezer storage stability of CGA 224 residues in homogenized samples in a freezer below approximately 8 ºC for two years. The homogenized commodities, (apples, tomatoes, potato tubers, rape seed and maize seed) were spread in a thin layer and sprayed with a CGA 224 solution to produce suitable residue levels for the tests. The analyses were validated with procedural recoveries at each testing interval (Table ). The stability of CGA 224 residues in a soil sample was also tested. Hohl (999, 2/9) explained that tomatoes are often difficult to homogenize because of tomato skin particles and the anomalous result at day 84 was believed to be an outlier and should not be taken into account in assessing the storage stability. For similar reasons, the author suggested that the rape seed data at day 29 should also be treated as an outlier. Table Freezer storage stability data for CGA 224 sprayed onto homogenized plant matrices. Residues are unadjusted for analytical recoveries. Storage interval, days Procedural recov % CGA 224, mg/kg APPLES were homogenized and sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). Storage interval, days Procedural recov % CGA 224, mg/kg TOMATOES were homogenized and sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). 84% % % % % 86% % 9%

40 826 Thiamethoxam Storage Procedural recov CGA 224, mg/kg Storage Procedural recov CGA 224, mg/kg interval, days % interval, days % 9 9% 9% % 6% % 8% % 82% % 8% % % % 95% % 9%.9..4 residues apparently stable residues apparently stable POTATO TUBERS were homogenized and sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). RAPE SEED was homogenized and sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). 2% 6% % 96% % 68% % 8% % 2% % 9% % 8% % 69% % 88% % 94% % 94% % 95%...2 residues apparently stable residues apparently stable MAIZE GRAI was homogenized and sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). SOIL was sprayed with CGA 224 and stored in polyethylene containers below approx 8 C (Hohl, 999, 2/9). 6% % 99% % 6% % 8% % % % 9% % 8% % 8% % % % 9% % 9% % 84% residues apparently stable residues apparently stable Starner (2, 54) tested the freezer storage stability of thiamethoxam and CGA 224 fortified at.5 mg/kg into control samples of cranberries. Starner (26, 845) tested the freezer storage stability of thiamethoxam and CGA 224 fortified at. mg/kg into control samples of hops. Table 8 Freezer storage stability data for thiamethoxam and CGA 224 fortified into control samples of cranberries and hops. Residues are unadjusted for analytical recoveries. Storage Procedural recov thiamethoxam, mg/kg Storage Procedural recov CGA 224, mg/kg interval, days % interval, days % CRABERRIES were fortified with thiamethoxam at.5 mg/kg and stored frozen below approx C (Starner, 2, 54). CRABERRIES were fortified with CGA 224 at.5 mg/kg and stored frozen below approx C (Starner, 2, 54). 85% 9% 88% % 6% 62% inconclusive on stability or instability inconclusive on stability or instability HOPS samples were fortified with thiamethoxam at. mg/kg and stored frozen below approx 2 C (Starner, 26, 845). HOPS samples were fortified with CGA 224 at. mg/kg and stored frozen below approx 2 C (Starner, 26, 845). % 22% 2% % 5% 5%.2.2. residues apparently stable residues apparently stable Corley (26, 46) tested the freezer storage stability of thiamethoxam and CGA 224 fortified at.5 mg/kg into control samples of barley grain, straw, hay and processed commodities. 2 Hohl, 999, study 2/9. Suggested outlier. 2 Soil. The soil data at day are too variable to be of use.

41 Thiamethoxam 82 Table 9 Freezer storage stability data for thiamethoxam and CGA 224 fortified into control samples of barley grain, straw, hay and processed commodities (Corley, 26, 46). Residues are unadjusted for analytical recoveries. Storage interval, days Procedural recov % thiamethoxam, mg/kg Storage interval, days Procedural recov % CGA 224, mg/kg BARLEY GRAI were ground and fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. BARLEY GRAI were ground and fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. 59 9% % residues apparently stable residues apparently stable BARLEY HAY was ground and fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. BARLEY HAY was ground and fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. 59 % % residues apparently stable residues apparently stable BARLEY STRAW was ground and fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. BARLEY STRAW was ground and fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC % % residues apparently stable residues apparently stable PEARLED BARLEY was ground and fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. PEARLED BARLEY was ground and fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. 82 9% %.8..4 residues apparently stable residues apparently stable BARLEY BRA was ground and fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. BARLEY BRA was ground and fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. 94% % residues apparently stable residues apparently stable BARLEY FLOUR was fortified with thiamethoxam at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. BARLEY FLOUR was fortified with CGA 224 at.5 mg/kg and stored frozen between 26 ºC and 4 ºC. 5% % residues apparently stable residues apparently stable Grunenwald and Eudy (2, 4 98) tested the freezer storage stability of thiamethoxam and metabolites CGA 224 and CGA 265 at residue levels in animal commodities. Control samples of bovine muscle, bovine liver, milk and eggs were individually fortified with thiamethoxam, CGA 224 and CGA 265 and stored at approximately 2 ºC for a minimum of 5 6 months. Lin and Oakes (22, ABR-982) extended the tests on CGA 224 in bovine liver to 4 months. Table 2 Freezer storage stability data for thiamethoxam, CGA 224 and CGA 265 fortified into animal commodities. Residues are unadjusted for analytical recoveries. Storage interval, days Procedural recov % analyte, mg/kg BOVIE MUSCLE homogenized and fortified with.5 mg/kg thiamethoxam and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). thiamethoxam Storage interval, days Procedural recov % analyte, mg/kg BOVIE LIVER homogenized and fortified with.5 mg/kg thiamethoxam and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). thiamethoxam 88% 89% 89% 82% 8% 8% 92% 8% 89% 88% 85 94% 92% % 95% % 94% % 92% % 9% % 9% % 9% %.4.9 residues apparently stable residues apparently stable MILK fortified with.5 mg/kg thiamethoxam and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). thiamethoxam EGG fortified with.5 mg/kg thiamethoxam and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). thiamethoxam 86% 88% 9% 82% 9% 9% 88% 86% 8% 5%

42 8 Thiamethoxam Storage Procedural recov analyte, mg/kg Storage Procedural recov analyte, mg/kg interval, days % interval, days % 62 % 92% % 92% % % 9% % 88% % 95% % 2% % 9% residues apparently stable residues apparently stable BOVIE MUSCLE homogenized and fortified with.5 mg/kg CGA 224 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). BOVIE LIVER homogenized and fortified with.5 mg/kg CGA 224 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). (Lin and Oakes, 22, ABR-982) CGA 224 CGA % 94% 94% 9% 8% 88% 89% 8% 94% 8% 85 9% 95% % 96% % 9% % 92%.4.44 % % % 99% % 9% % % 85%.42.2 residues apparently stable residues apparently stable MILK fortified with.5 mg/kg CGA 224 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). EGG fortified with.5 mg/kg CGA 224 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). CGA 224 CGA 224 9% 94% 95% 92% 88% 96% 94% 9% 94% 8% 62 8% 99% % 9% % % 92% % 9% % 99% % % % 92%.4.44 residues apparently stable residues apparently stable BOVIE MUSCLE homogenized and fortified with.5 mg/kg CGA 265 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). BOVIE LIVER homogenized and fortified with.5 mg/kg CGA 265 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). CGA 265 CGA % 8% 89% 86% % 88% % 8% 8% 85 9% % 8% % 9% % 89% % 8% % 92% % 89% % 8%.4.4 residues apparently stable residues apparently stable MILK fortified with.5 mg/kg CGA 265 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). EGG fortified with.5 mg/kg CGA 265 and stored in glass jars below approx -2 C (Grunenwald and Eudy, 2, 4 98). CGA 265 CGA % 9% 92% 85% 9% 98% 94% 9% 9% 64% 62 8% 89% % % % 9% % 9% % % 92% % 84% %.5.5 residues apparently stable residues apparently stable USE PATTER Thiamethoxam, a nicotinoid compound, has broad spectrum activity against sucking and chewing insects in vegetables, ornamentals, field crops, deciduous fruit, citrus, cotton and rice. It possesses contact and stomach activity. Its action against foliar feeding insects following; seed treatment, application to soil, through irrigation systems, or when applied to the trunks of trees, results from its systemic properties.

43 Thiamethoxam 829 Copies or English translations of thiamethoxam labels from the following countries were made available to the Meeting: Brazil, Bulgaria, Cameroon, Czech Republic, Germany, Ghana, Hungary, Italy, Japan, Romania, South Africa, Spain, UK and USA. GAP information was also provided from Australia (labels provided), Côte d'ivoire, Indonesia (label provided), Japan, Kenya and etherlands. Table 2 Registered foliar uses of thiamethoxam in horticultural and field crops Crop Country Application Form Type Max rate kg ai/ha Max conc kg ai/hl Spray vol, L/ha Max number.96 a Almond Spain WG foliar Apple Italy WG foliar.. Apple Japan SG foliar.5 2 Apple Spain WG foliar.5 2 Apples Hungary WG foliar.5 Apricot Japan SG foliar.5 2 Asparagus Japan SG foliar.5 Balsam pear Japan SG foliar.5 Banana Japan SG foliar.5 Barley USA WG foliar.. a 2 Bean Brazil WG foliar.5 2 Blackberry USA WG foliar.5. a Blueberry USA WG foliar..2 a Brassica greens, USA WG foliar.96.9 a leafy b Brassica leafy veg, Japan SG foliar.5 2 non-heading (except Komatsuma, kale, pak-choi) Brassica, head and USA WG foliar.9 stem c Broccoli Italy WG foliar.5.5 Broccoli Japan SG foliar. Broccoli Spain WG foliar. 2 Cabbage Brazil WG foliar.25 Cabbage Brazil WG foliar.2 Cabbage Japan AL foliar.5 Cabbage Japan SG foliar. Cacao Cameroon WG foliar, knapsack Cacao Cameroon WG foliar, mist blower Caneberry USA WG foliar.5. a Capsicum (forced) Hungary WG foliar. 2 Capsicum (freerange) Hungary WG foliar.6 8 Cauliflower Japan SG foliar. Cherry Italy WG foliar.. Cherry Spain WG foliar.5 2 Cherry, sweet Japan SG foliar.5 2 Chinese cabbage Japan SG foliar. Citrus Australia WG foliar.5 49 Citrus Brazil WG foliar.5.5 L/tree 2 Citrus Spain WG foliar.5 Citrus Indonesia ZC includes foliar lambdacyhalothrin Citrus fruits Italy WG foliar.5. PHI days

44 8 Thiamethoxam Crop Country Application Form Type Max rate kg ai/ha Max conc Spray vol, Max kg ai/hl L/ha number Citrus fruits Japan AL foliar.5 Citrus fruits Japan SG foliar.5 Citrus fruits USA WG foliar.96.9 a Cole crops Hungary WG foliar.5 6 Common bean Japan SG foliar. Cotton Australia WG foliar.5 Cotton Brazil WG foliar Cotton Spain WG foliar.5 Cotton USA WG foliar.. a 2 Cotton USA ZC includes foliar.54. a 2 lambdacyhalothrin Courgette Spain WG foliar. 2 Courgettes Italy WG foliar. 2 Cranberry USA WG foliar or..2 a irrigation Cucumber Italy WG foliar. 2 Cucumber Japan AL foliar.5 Cucumber Japan SG foliar.5 Cucumber Spain WG foliar. 2 Cucumber (forced) Hungary WG foliar. 2 Cucumber (freerange) Hungary WG foliar.6 8 Cucurbit vegetables USA WG foliar.96.9 a Egg plant Italy WG foliar. 2 Egg plant Japan AL foliar.5 Egg plant Japan SG foliar.5 Egg plant Spain WG foliar. 2 Fruiting vegetables d USA WG foliar.96.9 a Globe artichoke USA WG foliar.5. a 4 Grapes Hungary WG foliar.5 Grapes Italy WG foliar Grapes Japan SG foliar.5 2 Grapes Spain WG foliar.5 2 Grapes USA WG foliar.6.2 a 5 Guava Japan SG foliar.5 2 Komatsuma Japan SG foliar.5 2 Leafy vegetables, USA WG foliar.96.2 a except Brassica Lettuce and similar Italy WG foliar.5 Lettuce and similar Spain WG foliar. 2 2 Lettuce, head Japan SG foliar.5 2 Loofah, smooth Japan SG foliar.5 Mango Japan SG foliar.5 2 Melon Brazil WG foliar. 2 Melon Italy WG foliar. 2 Melon Spain WG foliar. 2 Melons except Japan SG foliar.5 watermelon ectarine Italy WG foliar.5.5 ectarine Spain WG foliar.5 2 Okra Kenya WG foliar,. knapsack Onion Hungary WG foliar.5 5 Onion, Welsh Japan SG foliar. PHI days

45 Thiamethoxam 8 Crop Country Application Form Type Max rate kg ai/ha Max conc Spray vol, Max kg ai/hl L/ha number Pak-choi Japan SG foliar.5 2 Passion fruit Kenya WG foliar. Pea Brazil WG foliar.5 2 Peach Hungary WG foliar.4 8 Peach Italy WG foliar.5.5 Peach Japan SG foliar.5 Peach Spain WG foliar.5 2 Peanut Brazil WG foliar.5 42 Pear Italy WG foliar.. Pear Japan SG foliar.5 Pear Spain WG foliar.5 2 Peas Hungary WG foliar.25 5 Pecan USA WG foliar.. a Pecan USA ZC includes foliar.54. a lambdacyhalothrin Peppers Italy WG foliar. 2 Peppers Spain WG foliar. 2 Peppers, bell Japan AL foliar.5 Peppers, bell Japan SG foliar.5 Peppers, chilli Japan SG foliar. Peppers, sweet Japan SG foliar. (small size), shishitou Persimmon, Japanese Japan SG foliar.5 Plum Italy WG foliar.5.5 Plum Spain WG foliar.5 2 Plum, Japanese Japan SG foliar.5 2 Pome fruits USA WG foliar a 5 Pome fruits USA WG foliar a Potato Brazil WG foliar.5 Potato Hungary WG foliar.2 5 Potato Italy WG foliar.5 2 Potato Japan SG foliar.5 Potato Japan SG foliar.. 25 Potato Spain WG foliar.25 4 Potatoes (starch and etherlands WG aerial spray seed) Radish USA WG foliar.. a Radish, Japanese Japan SG foliar.5 2 Raspberry USA WG foliar.5. a Rice Brazil WG foliar Rice Japan SC foliar.65 2 Rice Japan SC includes foliar spray azoxystrobin Rice Japan SC includes foliar spray, azoxystrobin helicopter Rice Japan SC includes foliar spray, azoxystrobin aerial Rocket salad Italy WG foliar.5 Root vegetables USA WG foliar.. a (except radish and sugar beet) e Soya bean Japan AL foliar.5 2 Soya bean Japan SG foliar. 2 PHI days

46 82 Thiamethoxam.5 a Crop Country Application Form Type Max rate Max conc Spray vol, Max PHI kg ai/ha kg ai/hl L/ha number days Soya bean USA ZC includes foliar.45.9 a lambdacyhalothrin Soya beans Brazil WG includes foliar cyproconazole Spinach Japan SG foliar.5 2 Stone fruits USA WG foliar.96.9 a Strawberry Brazil WG foliar. 2 Strawberry Japan AL includes foliar.5 2 emamectin and difenoconazole Strawberry USA WG foliar..9 a Sunflower Hungary WG foliar Tea Japan SG foliar Tea Japan WG includes foliar lufenuron Tea, green, black Japan SG foliar.5 Tomato Australia WG foliar.2 42 Tomato Brazil WG foliar.2 2 Tomato Cameroon WG foliar, knapsack Tomato Italy WG foliar. 2 Tomato Japan AL foliar.5 Tomato Japan SG foliar.5 Tomato Spain WG foliar. 2 Tomato (forced) Hungary WG foliar. 2 Tomato (free-range) Hungary WG foliar.6 8 Tomato (small size) Japan SG foliar.5 2 Tuberous and corm USA WG foliar. vegetables f Tuberous and corm USA ZC includes foliar a vegetables f lambdacyhalothrin Watermelon Brazil WG foliar.5 Watermelon Italy WG foliar. 2 Watermelon Japan SG foliar.5 Watermelon Spain WG foliar. 2 Wheat Brazil WG foliar Wheat, autumn Hungary WG foliar.4 a Maximum total kg ai/ha for season. b US crop group. Leafy Brassica greens vegetables: Chinese cabbage (bok choy), collards, kale, mizuna, mustard greens, mustard spinach, rape greens. c US crop group. Head and stem Brassica vegetables: broccoli, Chinese broccoli, Brussels sprouts, cabbage, Chinese mustard cabbage, Chinese cabbage, cauliflower, kohlrabi. d US crop group. Fruiting vegetables: egg plant, ground cherry, pepino, peppers (bell, chilli, cooking, pimento, sweet), tomatillo, tomato. e US crop group. Root vegetables: carrot, celeriac, chicory, edible burdock, garden beet, ginseng, horseradish, oriental radish, parsnip, rutabaga, salsify, black salsify, Spanish salsify, skirret, turnip, turnip rooted chervil, turnip rooted parsley. f US crop group. Tuberous and corm vegetables: arracacha, arrowroot, canna, cassava (bitter and sweet), chayote (root), Chinese artichoke, chufa, dasheen, ginger, Jerusalem artichoke, leren, potato, sweet potato, tanier, turmeric, yams, yam bean.

47 Thiamethoxam 8 Table 22 Registered uses (in-furrow, drench, band, base of tree, drip, trickle and other soil treatments) of thiamethoxam in horticultural and field crops. Crop Country Application Form Type Max rate kg ai/ha Max number PHI days Apple Brazil WG drench on soil at base of tree,.25 L.5 6 per tree Apple South Africa SC apply with jug, ml product per tree.2 g/tree S 22 Banana Cameroon WG drench to stem, ml water per.6 2 plant,.2 kg ai/hl Banana Ghana WG drench to stem, ml water per.6 2 plant,.2 kg ai/hl Brassica vegetables USA SG hill drench, post sowing or transplant.9.9 a Brassica vegetables USA SG in-furrow spray or surface band incorp.9.9 a Brassica vegetables USA SG shanked into root zone, after transplant.9.9 a Brassica vegetables USA SG trickle or drip irrigation water.9.9 a Brassica vegetables USA SL hill drench, post sowing.9.9 a Brassica vegetables USA SL in-furrow spray or surface band incorp.9.9 a after sowing Brassica vegetables USA SL shanked into root zone, after.9.9 a establishment Brassica vegetables USA SL trickle or drip irrigation water.9.9 a Broccoli Italy WG drip and drench.2 Broccoli Japan GR spreading at plant base, late nursery stage,. g ai per plant Broccoli Spain WG drip irrigation. Bushberry USA SL surface band on each side of row,.2.2 a 5 incorp Bushberry b USA SG surface band on each side of row.2.2 a 5 Cabbage Brazil WG drench or drip on soil soon after.2 emergence Cabbages, head Japan GR spreading, late nursery stage,.5 g ai per nursery box Cabbages, head Japan SG drench, late nursery stage,.5 g ai per nursery box Cauliflower Japan GR spreading at plant base, late nursery stage,.25 g ai per plant Celery Japan GR soil incorporation, seedbed at potting,. g ai per plant Celery Japan GR soil incorporation, planting hole, at transplanting,. g ai per plant Chinese cabbage Japan GR soil incorp before sowing,.5 g ai per litre of soil Chinese cabbage Japan SG drench, late nursery stage,.5 g ai per nursery box (soil 4 litres) Citrus Brazil WG spray stem and soil under canopy Citrus South Africa SC apply with jug, 8 ml product per tree 4. g/tree S 2 Citrus fruits USA SL chemigation in the root zone, drip,.9.9 a trickle, microsprinkler Citrus fruits USA SL drench around the tree trunk out to root.9.9 a zone Citrus fruits USA SL soil surface band each side of the row.9.9 a Coffee Brazil GR includes apply granules to soil. annual 24 9 cyproconazole Coffee Brazil WG drench on soil under coffee tree.5 9 Coffee Brazil WG includes soil application by drench or spray,. 9 cyproconazole min 2 L/ha Courgettes Italy WG drip and drench.2 Cranberry USA WG foliar or irrigation..2 a Cucumber Brazil WG drench or drip on soil soon after.5 45 emergence Cucumber Italy WG drip and drench.2 Cucumber Japan GR spreading in planting hole at transplanting,.5 g ai per plant Cucurbit vegetables USA SG hill drench, post sowing or transplant.9.9 a Cucurbit vegetables USA SG shanked into root zone, after transplant.9.9 a 22 Seasonal stage instruction. Apply in the last 2 weeks of September. 2 Seasonal stage instruction. Apply from mid-august to mid-september. 24 Coffee, Brazil. Maximum annual dose.6 kg ai/ha.

48 84 Thiamethoxam Crop Country Application Form Type Max rate kg ai/ha Max number Cucurbit vegetables USA SG trickle or drip irrigation water.9.9 a Cucurbit vegetables USA SL hill drench, post sowing or transplant.9.9 a Cucurbit vegetables USA SL in-furrow spray or surface band incorp.9.9 a Cucurbit vegetables USA SL shanked into root zone, after transplant.9.9 a Cucurbit vegetables USA SL trickle or drip irrigation water.9.9 a Cucurbit USA SG in-furrow spray or surface band.9.9 a vegetables c Egg plant Brazil WG drench or drip on soil, soon after.5 4 planting Egg plant Italy WG drip and drench.2 Egg plant Japan GR soil incorporation, planting hole at transplanting,. g ai per plant Egg plant Spain WG drip irrigation indoor.2 Egg plant Spain WG drip irrigation outdoor. Fruiting vegetables USA SG hill drench, post sowing or transplant.9.9 a Fruiting vegetables USA SG in-furrow spray or surface band incorp.9.9 a Fruiting vegetables USA SG shanked into root zone, after transplant.9.9 a Fruiting vegetables USA SG trickle or drip irrigation water.9.9 a Fruiting vegetables USA SL hill drench, post sowing or transplant.9.9 a Fruiting vegetables USA SL in-furrow spray or surface band incorp.9.9 a Fruiting vegetables USA SL shanked into root zone, after transplant.9.9 a Fruiting vegetables USA SL trickle or drip irrigation water.9.9 a Grapes Brazil WG watering around plant base Grapes USA SG chemigation with sprinkler, trickle or.. a 6 drip Grapes USA SG hill drench, incorp.. a 6 Grapes USA SG surface band on each side of row,.. a 6 incorp Grapes USA SL chemigation in the root zone, drip, a 6 trickle, microsprinkler Grapes USA SL hill drench and use sufficient water to a 6 move dosage to root zone Grapes USA SL soil surface band each side of the row a 6 Green beans Spain WG drip irrigation indoor.2 Green beans Spain WG drip irrigation outdoor. Haricot bean Brazil WG drench or drip on soil soon after.5 6 emergence Hops USA SG chemigation with sprinkler, trickle or.. a 65 drip Hops USA SG hill drench, incorp.. a 65 Hops USA SG surface band on each side of row,.. a 65 incorp Hops USA SL chemigation in the root zone, drip,.. a 65 trickle, microsprinkler Hops USA SL hill drench and use sufficient water to.. a 65 move dosage to root zone Hops USA SL soil surface band each side of the row.. a 65 Komatsuma Japan GR soil incorporation at transplanting. Leafy vegetables d USA SG hill drench, post sowing or transplant.9.9 a Leafy vegetables d USA SG shanked into root zone, after transplant.9.9 a Leafy vegetables d USA SG trickle or drip irrigation water.9.9 a Leafy vegetables d USA SL hill drench, post sowing or transplant.9.9 a 65 Leafy vegetables d USA SL in-furrow spray or surface band incorp.9.9 a 65 Leafy vegetables d USA SL shanked into root zone, after transplant.9.9 a 65 Leafy vegetables d USA SL trickle or drip irrigation water.9.9 a 65 Leafy vegetables d USA SG in-furrow spray or surface band incorp.9.9 a Lettuce Brazil WG irrigation on seedling tray.5 Lettuce and similar Italy WG drip and drench.2 Lettuce and similar Spain WG drip irrigation. Lettuce, head Japan GR soil incorporation, seedbed, before sowing.5 g ai per litre of soil Lettuce, leaf Japan GR soil incorporation, seedbed, before sowing.5 g ai per litre of soil PHI days

49 Thiamethoxam 85 Crop Country Application Form Type Max rate kg ai/ha Max number Lotus root Japan GR spreading submerged. Mango South Africa SC apply with jug or drip irrigation, 6 ml.4 g/tree S 25 product per tree Melon Brazil WG drench or drip on soil soon after.5 64 emergence Melon Italy WG drip and drench.2 Melon Spain WG drip irrigation indoor.2 Melon Spain WG drip irrigation outdoor. Melons, except Japan GR soil incorporation, planting hole at transplanting,.5 g ai per plant watermelon Pak choi Japan GR soil incorporation at transplanting. Papaya Brazil WG drench on soil,.5 L per plant.2 Peppers Italy WG drip and drench.2 Peppers Spain WG drip irrigation indoor.2 Peppers Spain WG drip irrigation outdoor. Peppers sweet Japan GR soil incorporation, planting hole at transplanting,.5 g ai per plant (small size), shishitou Peppers, bell Japan GR soil incorporation, planting hole at transplanting,. g ai per plant Peppers, chilli Japan GR soil incorporation, planting hole at transplanting,.5 g ai per plant Peppers, sweet Brazil WG drench or drip on soil soon after.5 46 emergence Pineapple Brazil WG pre-seedling transplant immersion, kg ai/hl Pineapple Brazil WG soil drench at plant base, 45-6 days after transplant Potato Brazil WG in furrow or before mounding Potato Japan GR soil incorporation, row, at planting. Potatoes (seed) etherlands WG ground treatment of row at planting.25 Radish USA SG in trickle or drip irrigation after sowing.. a Radish USA SG in-furrow spray or surface band incorp.. a after sowing Radish USA SG soil incorp after sowing.. a Radish USA SL after sowing, add sufficient water to.. a 65 ensure root zone is reached. Radish USA SL in-furrow spray or surface band incorp.. a 65 Radish USA SL trickle or drip irrigation water.. a 65 Radish, Japanese Japan GR soil incorp at sowing.2 Rice Japan GR seed box application, 5 g product in 5.8 g per litre litres soil soil Rice Japan GR spreading, submerged at full heading.5 5 stage Rocket salad Italy WG drip and drench.2 Root vegetables USA SG in trickle or drip irrigation after sowing.2.2 a Root vegetables USA SG in-furrow spray or surface band incorp.2.2 a after sowing Root vegetables USA SG soil incorp after sowing.2.2 a Root vegetables USA SL after sowing, add sufficient water to.2.2 a 65 ensure root zone is reached. Root vegetables USA SL in-furrow spray or surface band incorp.2.2 a 65 Root vegetables USA SL trickle or drip irrigation water.2.2 a 65 Spinach Japan GR soil incorporation, row, at sowing. Strawberry Japan GR soil incorporation, planting hole at transplanting,.5 g ai per plant Strawberry USA SG as a plant hole treatment at transplant.2.2 a 5 Strawberry USA SG in trickle or drip irrigation.2.2 a 5 Strawberry USA SG in-furrow spray or surface band incorp.2.2 a 5 after transplanting PHI days 25 Seasonal stage instruction. Apply from last week in July to mid August.

50 86 Thiamethoxam Crop Country Application Form Type Max rate kg ai/ha Max number Strawberry USA SG post transplant drench.2.2 a 5 Strawberry USA SL drench, post transplant, add sufficient.2.2 a 65 water to ensure root zone is reached. Strawberry USA SL in-furrow spray or surface band incorp.2.2 a 65 Strawberry USA SL plant hole treatment.2.2 a 65 Strawberry USA SL trickle or drip irrigation water.2.2 a 65 Sugar beet Japan GR drench seedbed, before transplanting, 6.2 g ai/hl L/ha Sugar cane Brazil WG apply to stub base on both sides of row Sugar cane Brazil WG in furrow before planting.2 25 Sweet potato Japan GR soil incorporation, row, at planting.45 Taro Japan GR soil incorporation, row, at planting. Tomato Brazil WG drench or drip on soil soon after.2 emergence Tomato Brazil WG nursery application.6 g/m 2 Tomato Italy WG drip and drench.2 Tomato Japan GR soil incorporation, planting hole at transplanting,. g ai per plant Tomato South Africa SC soil drench. ml product per plant,.2 g/plant 2 GS 26 5 ml water per plant Tomato Spain WG drip irrigation indoor.2 Tomato Spain WG drip irrigation outdoor. Tuberous and corm USA SG apply product at planting impregnated.. a vegetables on dry granular fertilizer Tuberous and corm USA SG broadcast spray on soil at final hilling.. a vegetables operation Tuberous and corm USA SG chemigation at plant emergence.. a vegetables Tuberous and corm USA SG direct spray on soil at plant emergence.. a vegetables Tuberous and corm USA SG in-furrow spray at sowing of seed.. a vegetables pieces Tuberous and corm USA SL apply product at planting impregnated.. a 65 vegetables on dry granular fertilizer Tuberous and corm USA SL broadcast spray on soil at final hilling.. a 65 vegetables operation Tuberous and corm USA SL chemigation at plant emergence.. a 65 vegetables Tuberous and corm USA SL direct spray on soil at plant emergence.. a 65 vegetables Tuberous and corm USA SL in-furrow spray at sowing.. a 65 vegetables Watermelon Brazil WG drench or drip on soil.5 Watermelon Italy WG drip and drench.2 Watermelon Japan GR soil incorporation, planting hole at transplanting,. g ai per plant Watermelon Spain WG drip irrigation indoor.2 Watermelon Spain WG drip irrigation outdoor. Welsh onion Japan GR soil incorporation, row, at.45 transplanting Zucchini Brazil WG drench or drip on soil, soon after emergence.5 45 a Maximum total kg ai/ha for season. b US crop group. Bushberry: blueberry, currant, elderberry, gooseberry, huckleberry, juneberry, lingonberry, salal. c US crop group. Cucurbit vegetables: chayote, Chinese wax gourd, citron melon, cucumber, edible gourd, gherkin, momordica species, muskmelon (includes cantaloupe and honeydew), pumpkin, summer squash:, winter squash, watermelon. d US crop group. Leafy vegetables: amaranth, arugula, cardoon, celery, celtuce, Chinese celery, chrysanthemum, corn PHI days 26 Growth stage instruction. Apply at transplant and days later.

51 Thiamethoxam 8 salad, cress, dandelion, dock, endive, fennel, head lettuce leaf lettuce, orach, parsley, purslane, radicchio, rhubarb, spinach, Swiss chard. Table 2 Registered seed treatment uses of thiamethoxam in horticultural and field crops. Crop Country Application Use instructions and notes Form Dose, g ai/ kg seed Adzuki bean Japan SC 8 Alfalfa Romania FS 2 Barley Romania FS L product + 9 L water per tonne seed Barley USA FS Barley, autumn Romania FS 5 L product + 9 L water per tonne seed Barley, winter Czech FS 5 water dilution depends on seed treatment equipment Republic Barley, winter Hungary FS 5 ml product + 2 ml water per kg seed Beans a USA FS 5 formulation includes mefenoxam and fludioxonil Beet Bulgaria FS 2 ml product + 2 ml water per kg seed Broad bean USA FS 5 formulation includes mefenoxam and fludioxonil Cereals Bulgaria FS 5 ml product + 2 ml water per kg seed Chickpea USA FS 5 formulation includes mefenoxam and fludioxonil Common bean Japan SC 8 Cotton Australia FS 4.6 litres product per tonne of seed Cotton USA FS..4 mg per seed Endive etherlands WG 8 g/, seeds glasshouse use Endive etherlands WG 8 g/, seeds Fodder beet etherlands SC 5 g/, seeds Fodder beet UK FS 6 g ai/, seeds ml product per, seeds Lentil USA FS 5 formulation includes mefenoxam and fludioxonil Lettuce etherlands WG 8 g/, seeds glasshouse use Lettuce etherlands WG 8 g/, seeds Maize Australia FS 49 g/, seeds.4 ml product per seeds Maize Bulgaria FS 8 ml product + 2 ml water per kg seed Maize Czech FS 5 water dilution depends on seed treatment equipment Republic Maize Hungary FS 6 Maize etherlands SC 2 g/5, seeds Maize Romania FS 5 9 L product + 6 L water per tonne seed Maize USA FS.25 mg per kernel Mustard Czech FS 42 water dilution depends on seed treatment equipment Republic Oilseed crops b USA FS 4 Pea Czech FS 5 water dilution depends on seed treatment equipment Republic Pea Hungary FS 49 ml product + 2 ml water per kg seed Peas c USA FS 25 formulation includes mefenoxam and fludioxonil Pigeon pea USA FS 5 formulation includes mefenoxam and fludioxonil Popcorn USA FS.25 mg per kernel Potato Romania FS. 22 ml product +.8 L water per tonne seed Potato USA FS formulation includes fludioxonil Potatoes USA FS Rapeseed Germany FS 42 maximum rate.4 kg ai/ha corresponding to 8 kg rape seed per hectare Rapeseed UK FS 42 formulation includes fludioxonil and metalaxyl-m Rapeseed, spring Romania FS 2 Rice Brazil FS 2 4 ml product +.5 L water per kg seed Sorghum Australia FS 8 2. litres product per tonne seed Sorghum USA FS Soya bean Japan SC 8 Soya bean USA FS 5 Soya bean USA FS 5 formulation includes mefenoxam and fludioxonil Sugar beet etherlands SC 5 g/, seeds

52 88 Thiamethoxam Crop Country Application Use instructions and notes Form Dose, g ai/ kg seed Sugar beet Romania FS 2 L product + 2 L water per tonne seed Sugar beet UK FS 6 g ai/, seeds ml product per, seeds Sunflower Australia FS.9 g/, seeds. ml product per seeds Sunflower Bulgaria FS 5 9 ml product + ml water per kg seed Sunflower Hungary FS 48 Sunflower Romania FS 5 L product + 2 L water per tonne seed Sunflower USA FS.25 mg per seed Sweet corn Australia FS 49 g/, seeds.4 ml product per seeds Sweet corn USA FS.25 mg per kernel Wheat Romania FS L product + 9 L water per tonne seed Wheat USA FS Wheat, winter Czech FS 5 water dilution depends on seed treatment equipment Republic Wheat, winter Hungary FS 5 ml product + 2 ml water per kg seed a US crop group. Beans: black bean, cranberry bean, field bean, great orthern bean, kidney bean, lima bean, navy bean, pinto bean, runner bean, small red bean, snap bean, tepary bean, wax bean, yellow bean, adzuki bean, asparagus bean, blackeyed pea, catjang, Chinese longbean, cowpea, Crowder pea, moth bean, mung bean, rice bean, southern pea, urd bean, yardlong bean. b US crop group. Oilseed crops: black mustard seed, borage seed, crambe seed, field mustard seed, flax seed, Indian mustard seed, Indian rapeseed seed, rapeseed seed, and safflower seed. c US crop group. Peas: dwarf pea, edible-pod pea, English pea, field pea, garden pea, green pea, snow pea, sugar snap pea. RESIDUES RESULTIG FROM SUPERVISED TRIALS The Meeting received information on supervised field trials for thiamethoxam uses on crops that produced residue data. The commodities are grouped into Codex commodity groups. Crop group Commodities Table o. Citrus fruits Oranges: Spain Table 25 Orange, Indonesia Table 26 Citrus: USA Table 2 Pome fruits Apples: France, Italy Table Pome fruits: USA Table 29 Stone fruits Plums: USA Table Peach: USA Table Cherries: USA Table 2 Cherries: France, Italy, Spain, Switzerland Table Berries and other small fruits Strawberry: USA Table 4 Cranberry: USA Table 5 Blueberry: USA Table 6 Caneberry: USA Table Grapes: France, Italy, Spain, Switzerland Table 8 Assorted tropical fruits inedible peel Banana: Cameroon Table 9 Mango: South Africa Table 4 Papaya: Brazil, Côte d'ivoire Table 4

53 Thiamethoxam 89 Crop group Commodities Table o. Pineapple, Brazil Table 42 Brassica veg Broccoli, cabbage, mustard greens 2 : USA Table 4 Fruiting vegetables, Cucurbits Cucumber: USA Table 44 Cucumber: France, etherlands, Spain Table 45 Melon: Italy, Spain Table 46 Cantaloupe: USA Table 4 Summer squash: USA Table 48 Fruiting vegetables, other than Cucurbits Sweet corn: USA Table 49 Tomato: France, Italy, Spain, Switzerland Table 5 Tomato, bell pepper, hot pepper: USA Table 5 Sweet peppers: France, Italy, Spain, Table 52 Switzerland, UK Egg plant: Switzerland, UK Table 5 Okra: Côte d'ivoire Table 54 Leafy vegetables Lettuce: USA Table 55 Spinach: USA Table 56 Legume vegetables Snap beans, lima beans: USA Table 5 Succulent peas: USA Table 58 Pulses Dry beans: USA Table 59 Legume, pulse Peas (green pods), peas (dry seed): Denmark, Table 6 France, Germany Pulses Dry peas: USA Table 6 Soya beans, dry: USA Table 62 Root and tuber vegetables Carrot: USA Table 6 Radish: USA Table 64 Potato: France, Germany, Spain, Switzerland, Table 65 UK Potato: USA Table 66 Sugar beet: France, Germany, Italy, Table 6 etherlands, Spain, Sweden, Switzerland, UK Stalk and stem vegetables Artichoke: USA Table 68 Celery: USA Table 69 Cereal grains Maize: France, Germany, Spain Table Cereal grains Maize: USA Table Barley: USA Table 2 2 Mustard greens. ote that mustard greens is a leafy Brassica greens vegetable crop, but the commodity is within the Codex leafy vegetables group.

54 84 Thiamethoxam Crop group Commodities Table o. Barley: France, Germany, UK Table Wheat: France, Germany, Switzerland, UK Table 4 Wheat: France, Germany, UK Table 5 Rice: Brazil, Japan Table 6 Tree nuts Pecan: USA Table Oilseeds Sunflower: USA Table 8 Cotton: USA Table 9 Cotton: Greece, Spain Table 8 Oilseed rape: France, Germany, Sweden, UK Table 8 Seed for beverages Cacao beans: Côte d'ivoire Table 82 Coffee: Brazil Table 8 Legume animal feeds Pea forage and fodder: Denmark, France, Table 84 Germany Fodder, cereals Maize forage and fodder: USA Table 85 Maize forage and fodder: USA Table 86 Maize forage and fodder: France, Germany, Table 8 Spain Barley straw and fodder: USA Table 88 Barley straw and fodder: France, Germany, UK Table 89 Wheat straw and fodder: France, Germany, Table 9 Switzerland, UK Wheat straw and fodder: France, Germany, UK Table 9 Rice straw: Japan Table 92 Fodder, miscellaneous Beet leaves and tops: France, Germany, Table 9 etherlands, Spain, Sweden, Switzerland, UK Oilseed rape fodder and forage: France, Table 94 Germany, Sweden, UK Cotton gin by-products: USA Table 95 Dried herbs Hops: USA Table 96 Teas Tea: Japan Table 9 Trials were generally well documented with laboratory and field reports, although a number of trials from the USA contained no details on trial design, plot size and field sample size. Assurance was provided that protocols had been followed, so the trial data were accepted. Laboratory reports included method validation with procedural recoveries from spiking at residue levels similar to those occurring in samples from the supervised trials. Dates of analyses or duration of residue sample storage were also provided. Although trials included control plots, no control data are recorded in the tables except where residues in control samples exceeded the LOQ. Control samples are indicated in the summary tables with a "c".

55 Thiamethoxam 84 Residue data are recorded unadjusted for recovery except in particular cases (indicated) where unadjusted data were not available. In some studies, the reported residues had been adjusted for procedural recoveries for each set of analyses, but only when the recoveries were less than %. Thiamethoxam is a systemic compound and may be applied by various methods: seed treatment, soil, furrow, basal and band treatments and foliar treatment. Some crops may be subject to these various uses or combinations of the uses. Seed treatments may be described in terms of g ai/kg seed or as kg ai/ha if the sowing rate (weight of seed per hectare) is taken into account. For some sugar beet seed treatments, the application rate was provided as g ai/unit, where the unit is, seeds. When the sowing rate (number of seeds per hectare) is known, the application rate as kg ai/ha may be calculated. In some seed treatment trials, the treated seed were analysed for thiamethoxam content for comparison with the nominal value. It was explained that the average seed loading achieved in the commercial seed-treatment industry was approximately %. Trials with seed loading exceeding % of nominal would not be considered as deviating from the protocol. For seed treatments, the PHI is taken as the interval between sowing and sampling. Seed may be treated some time before sowing, so the interval between treatment and sampling is inappropriate as a PHI for a seed treatment. Residues and application rates have generally been rounded to two significant figures or, for residues near the LOQ, to one significant figure. Residue values from the trials conducted according to maximum GAP have been used for the estimation of maximum residue levels and STMR and HR values. Those results included in the evaluation are underlined. Most trial designs used non-replicated plots. Most field reports provided data on the sprayers used, plot size, field sample size and sampling date. Table 24 Summary of sprayers, plot sizes and field sample sizes in the supervised trials Crop Place Year Sprayer Plot size Sample size Apple USA 996, 2 Air blast, back pack, commercial?? Artichoke USA 22 CO 2 backpack m 2 2 buds Bananas Cameroon 22 knapsack 8 plants to ha? Barley France seed treatment equipment 4 m kg Barley Germany seed treatment equipment m kg Barley UK seed treatment equipment 2 m 2.4 kg Barley USA 2 22 CO 2 backpack, ATV CO 2 sprayer 46 9 m 2? Beans, dry USA 2 seed treatment equipment 44 m 2 min.5 kg Blueberry USA 2 CO 2 backpack, tractor with hydraulic 4 8 m 2.5 kg boom Broccoli USA 99 2 CO 2 backpack?.5 kg Cabbage USA 99 2 CO 2 backpack? 2 plants Cacao Côte d'ivoire 2 motorized mist blower m 2 2 kg Caneberry USA 22 CO 2 backpack 2 9 m 2 min.5 kg Cantaloupe USA 996??? Carrot USA 2 CO 2 backpack, R&D sprayer, 8 4 m 2 min 2 kg commercial sprayers Celery USA 99 CO 2 backpack?? Cherry France mist blower 5 8 trees 2 kg Cherry Italy mist blower, knapsack 4 5 trees 2. kg Cherry Spain mist blower, knapsack 6 trees kg Cherry Switzerland knapsack 6 trees 2.8 kg Cherry USA 2 Air blast?? Coffee Brazil plastic syringe, soil drench, granules m 2 kg Cotton Greece knapsack 5 m 2 kg Cotton Spain knapsack 4 m 2 kg Cotton USA 99 seed treatment equipment + knapsack,?? tractor sprayer Cotton USA 998 seed treatment equipment + CO 2 backpack, tractor sprayers??

56 842 Thiamethoxam Crop Place Year Sprayer Plot size Sample size Cranberry USA 2 CO 2 backpack 5 m 2.5 kg Cucumber Europe drench, syringe, drip 5 64 m 2 2 fruits Cucumber USA ??? Egg plant Switzerland 99 knapsack 8 2 m 2 2 fruits Grapefruit USA 25 backpack, air blast? min 24 fruit Grapes France 2 26 knapsack, mist blower m 2. 2 kg Grapes Spain 2 22 knapsack, handgun sprayer, backpack 2 m kg Grapes Switzerland 2 26 knapsack 2 24 m kg Hops USA 22 CO 2 backpack 49 8 m 2 min.5 kg Lemon Spain motor sprayer, high pressure sprayer, m kg spray gun Lemon USA 25 backpack, air blast, tractor? min 24 fruit Lettuce USA 99 2 CO 2 backpack, soil injector, research?? backpack sprayer Lima beans USA 2 seed treatment equipment m kg Maize France seed treatment equipment m 2.2 kg Maize Germany seed treatment equipment m 2.9 kg Maize Spain seed treatment equipment 2 44 m kg Maize USA 998 seed treatment equipment?? Mandarin Spain knapsack 8 95 m 2 2 fruit Mango South Africa 2 24 jug for drench 2 trees 2 fruits Melon Italy, Spain 22 2 jug for drench, syringe, drip 4 25 m 2 2 fruits Mustard USA 99 2 CO 2 backpack? 2 kg greens Okra Côte d'ivoire 24 seed treatment equipment, knapsack 225 m 2 6 kg Orange Indonesia 29 knapsack 4 m 2 5 kg Orange Spain backpack, air blast, motor sprayer m fruits Orange USA 25 backpack, tractor, air blast? min 24 fruit Papaya Brazil 22 syringe trees 2 fruits Papaya Côte d'ivoire 24 atomizer 6 trees 2 fruits Peach USA 2 Air blast?? Pear USA 996 Air blast?? Peas Denmark 996 seed treatment equipment 42 m 2 kg Peas France seed treatment equipment 4 2 m kg Peas Germany 99 seed treatment equipment m 2.5 kg Peas USA 2 seed treatment equipment m kg Pecan USA 998 Air blast, mist blower?? Peppers Italy knapsack, motor sprayer 8 m kg Peppers Spain knapsack, motor sprayer, drip 2 4 m 2..4 kg Peppers Switzerland knapsack 6 2 m 2 2 fruits Peppers USA 996??? Pineapple Brazil 25 drench 5 25 m 2? Plum USA 2 Air blast?? Popcorn USA 998 seed treatment equipment?? Potato France 99 knapsack 6 m kg Potato Germany 99 plot sprayer m kg Potato Spain knapsack 8 m 2 2 kg Potato Switzerland knapsack 45 m kg Potato UK compressed air, small plot 5 2 m 2 24 kg Potato USA 998 CO 2 backpack, tractor, plot, R&D?? Radish USA 2 CO 2 backpack, furrow applicator, 8 9 m 2 min.5 2 kg banded boom Rapeseed France seed treatment equipment 4 m 2. 2 kg Rapeseed Germany seed treatment equipment, lab glass jar 62 m kg Rapeseed UK seed treatment equipment 2 84 m kg Rice Brazil 2 24 CO 2 powered 45 9 m 2.5 kg Rice Japan knapsack, battery powered m kg Snap beans USA 2 seed treatment equipment m kg Soya bean USA 22 seed treatment equipment?? Spinach USA CO 2 backpack, small plot, tractor plot?? Strawberry USA 2 2 CO 2 backpack, tractor, boom??

57 Thiamethoxam 84 Crop Place Year Sprayer Plot size Sample size Sugar beet France seed treatment equipment 2 48 m 2 2 plants Sugar beet Germany seed treatment equipment m kg Sugar beet Italy seed treatment equipment 4 m 2 2 kg Sugar beet etherlands seed treatment equipment 2 2 m kg Italy Spain Sweden UK Switzerland Summer USA 996??? squash Sunflower USA 999 seed treatment equipment?? Sweet corn USA 998 seed treatment equipment?? Tea Japan 998, 22 knapsack, manual sprayer 8 2 m kg Tomato France 999 plot sprayer 2 m fruits Tomato Italy motor sprayer, knapsack, plot sprayer 9 m 2.-4 kg Tomato Spain motor sprayer, knapsack, plot sprayer 2 m 2 2 fruits 4 kg Tomato Switzerland knapsack 8 m 2 2 fruits Tomato USA CO 2 backpack?? Wheat France seed treatment equipment, knapsack, 6 m 2.5 kg Wheat Germany seed treatment equipment, plot sprayer 24 m kg Wheat Switzerland knapsack 6 m 2. kg Wheat UK plot sprayer, seed treatment 2 m 2.5 kg Table 25 Thiamethoxam residues in citrus fruits resulting from supervised trials in Spain CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval b ORAGE Spain, 995 (Salustiano) Spain, 995 (Washington avel) Spain, 995 (avelino) Spain, 995 (avelino) WG.. 2 WG.. 2 WG.. 2 WG.. 2 peel pulp fruit a peel pulp fruit a peel pulp fruit a orange juice peel pulp fruit a orange juice < <.5 /95 8/95 9/95 /95

58 844 Thiamethoxam CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval b Spain, 99 /9 (Valencia late) WG.. 2 Spain, 99 WG.. (Valencia late) 2 Spain, 99 WG.. (Valencia late) 2 Spain, 999 (avelino) Spain, 999 (W. abel) Spain, 22 (avel Foios) Spain, 22 (avelina) Spain, 22 (avel) Spain, 22 (avelina) WG WG WG WG.5 98 WG WG peel pulp fruit a orange juice marmalade peel pulp fruit a orange juice marmalade peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a (2) (2) (2) (2) (2) c (2) (2) (2) (2) (2) (2).4. (2).2.2 (2).2.2 (2) (2) /9 9/9 2/99 2/

59 Thiamethoxam 845 CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval b Spain, 2 - (avel Lane Late) LEMO Spain, 996 (Verna) Spain, 996 (Verna) Spain, 999 (Verna) Spain, 999 (Finos) Spain, 999 (Verna) Spain, 999 (Finos) Spain, 999 (Fino) Spain, 999 (Verna) WG WG. 2 WG. 2 WG WG WG WG..5 2 WG WG peel flesh fruit a peel pulp fruit a lemon juice peel pulp fruit a lemon juice peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a (2) (2) (2) (2) (2).2.2 (2) (2) < (2) (2) (2) (2) (2) (2) (2) /96 8/96 /99 8/99 9/99 2/99 6/99 /99

60 846 Thiamethoxam CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval b MADARI Spain, 999 (Clementinos) WG peel pulp fruit a (2) (2).2 22/99 Spain, 22 (Clemenules) Spain, 22 (Clemenules) Spain, 22 (Tomatera) Spain, 22 (Clemenules) Spain, 2 (Ellendale) Spain, 2 (Fortune) Spain, 2 (Fortune) Spain, 2 (Fortune) WG.5 98 WG.5 2 WG WG.5 2 WG WG WG WG.5 94 a Residues in fruit calculated from residues in peel and pulp. b c: sample from untreated control plot. peel pulp fruit a peel pulp fruit a peel pulp fruit a peel pulp fruit a peel flesh fruit a peel flesh fruit a peel flesh fruit a peel flesh (2) (2) (2).6.5 (2) (2) (2) (2).6.5 (2) (2) (2) (2) Ely and Clarke, 24, -. Mandarins. The plot size appears anomalous: plot size 6 m m, row, 6 trees in one line. In response to a query, it was suggested that the 6 m m is the distance between rows and trees.

61 Thiamethoxam 84 Table 26 Thiamethoxam residues in oranges resulting from supervised trials in Indonesia ORAGE Application PHI Residue, mg/kg a (thiamethoxam + CGA 224) country, Form kg ai/ha kg ai/hl water no. days peel (L/ha) interval Indonesia, 29 ZC (Siam Purworejo), ( days) dry season, Central Java Indonesia, 29 (Siam Garut), dry season, West Java Indonesia, 29 (Siam Garut), wet season, West Java a ZC ( days) ZC ( days) Ref 82/SPKS/PPK- PPI/V/29 82/SPKS/PPK- PPI/V/29 82/SPKS/PPK- PPI/V/29 CGA 224 was not detected in pulp or peel. Residue in was calculated from the thiamethoxam concentration in the peel and the weights of peel, pulp and. Thiamethoxam may be used as a soil treatment or in foliar applications during the production of citrus fruits. Several use patterns were examined in the supervised trials in the USA on citrus (Ediger, 26, T8964-4): Soil surface spray application of SL (soluble concentrate) formulation at.9 kg ai/ha, spray volume L/ha. Two foliar applications of WG (water dispersible granule) formulation as cover sprays at.96 kg ai/ha with spray volumes of L/ha (low volume) and an interval of days. Two foliar applications of WG formulation as cover sprays at.96 kg ai/ha with spray volumes of 94 L/ha (high volume) and an interval of days. Two foliar applications of WG formulation as cover sprays at.29 kg ai/ha with spray volumes of 94 L/ha and an interval of days.

62 848 Thiamethoxam Two foliar applications of WG formulation as cover sprays at.48 kg ai/ha with spray volumes of 94 L/ha and an interval of days. This exaggerated rate (5 ) was chosen to produce oranges for the processing trial Table 2 Thiamethoxam residues in citrus resulting from supervised trials in the USA. Replicate values arise from replicate field samples CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval ORAGE USA (FL), 25 SL.9 soil 2 T (Valencia) orange surface 2 VK-IR-5-69 USA (FL), 25 (Valencia) orange USA (FL), 25 (Valencia) orange USA (FL), 25 (Hamlin) orange USA (FL), 25 (Hamlin) orange USA (FL), 25 (avel) orange USA (FL), 25 (Ambersweet) orange USA (TX), 25 (-) orange SL SL SL SL SL SL SL USA (CA), 25 SL (Cutter Valencia) orange USA (CA), 25 SL (Valencia) orange USA (CA), 25 SL (avel) orange USA (FL), 25 (avel) orange USA (FL), 25 (Valencia) orange USA (FL), 25 (Valencia) orange USA (FL), 25 (Valencia) orange USA (FL), 25 (Hamlin) orange USA (FL), 25 (Hamlin) orange SL.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface WG.96 2 d WG d WG d WG.96 2 d WG d <. (2) <. (2) T VK-IR T VK-IR-5-69 T VK-IR T VK-IR T VK-IR T VK-IR-5-69 T SA-IR T WC-IR T WC-IR-5-6 T WC-IR-5-6 T VK-IR-5-6 T VK-IR-5-69 T VK-IR T VK-IR-5-69 T VK-IR T VK-IR-5-695

63 Thiamethoxam 849 CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (FL), 25 WG T (avel) orange d VK-IR USA (FL), 25 (Ambersweet) orange USA (TX), 25 (-) orange USA (TX), 25 (-) orange WG.96 2 d WG d WG d USA (CA), 25 WG (Cutter Valencia) d orange USA (CA), 25 (Valencia) orange USA (CA), 25 (avel) orange USA (CA), 25 (avel) orange USA (FL), 25 (avel) orange USA (CA), 25 (Cutter Valencia) orange USA (CA), 25 (Cutter Valencia) orange USA (FL), 25 (Valencia) orange GRAPEFRUIT USA (FL), 25 (Flame) grapefruit USA (FL), 25 (Marsh White) grapefruit USA (TX), 25 (Rio Red) grapefruit USA (CA), 25 (Mellogold) grapefruit USA (CA), 25 (Rio Red) grapefruit USA (FL), 25 (Flame) grapefruit USA (FL), 25 (Flame) grapefruit WG d WG d WG d WG d WG d WG d WG.48 2 d SL SL SL SL SL SL.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface WG d T VK-IR-5-69 T SA-IR T SA-IR T WC-IR T WC-IR-5-6 T WC-IR-5-6 T WC-IR-5-6 T VK-IR T WC-IR T WC-IR T VK-IR T VK-IR-5-6 T VK-IR-5-6 T SA-IR-5-65 T WC-IR-5-66 T WC-IR-5-6 T VK-IR-5-6 T VK-IR-5-6

64 85 Thiamethoxam CITRUS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (FL), 25 WG T (Marsh White) grapefruit d VK-IR-5-6 USA (TX), 25 (Rio Red) grapefruit USA (TX), 25 (Rio Red) grapefruit USA (CA), 25 (Mellogold) grapefruit USA (CA), 25 (Rio Red) grapefruit USA (FL), 25 (Flame) grapefruit USA (FL), 25 (Flame) grapefruit LEMO USA (FL), 25 (Meyer) lemon USA (CA), 25 (Pryor) lemon USA (CA), 25 (Lisbon) lemon USA (CA), 25 (Eureka) lemon USA (AZ), 25 (Limoneira) lemon USA (FL), 25 (Meyer) lemon USA (FL), 25 (Meyer) lemon USA (CA), 25 (Pryor) lemon USA (CA), 25 (Lisbon) lemon USA (CA), 25 (Eureka) lemon USA (AZ), 25 (Limoneira) lemon WG d WG d WG.96 2 d WG d WG d WG d SL SL SL SL SL.9 soil surface.9 soil surface.9 soil surface.9 soil surface.9 soil surface WG d WG d WG d WG d WG d WG.96 2 d <. (2) T SA-IR-5-65 T SA-IR-5-65 T WC-IR-5-66 T WC-IR-5-6 T VK-IR-5-6 T VK-IR-5-6 T VK-IR-5-68 T WC-IR-5-69 T WC-IR-5-6 T WC-IR-5-6 T WC-IR-5-62 T VK-IR-5-68 T VK-IR-5-68 T WC-IR-5-69 T WC-IR-5-6 T WC-IR-5-6 T WC-IR-5-62

65 Thiamethoxam 85 Table Thiamethoxam residues in apples resulting from supervised trials in Europe APPLES Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval France, 99 WG apples 95 (Idared) d Italy, 99 (Stark WG /9 Spur Red) d Italy, 99 (Jonagold) WG d - - apples apples apples apples apples apples apples apples apples apples /9 Thiamethoxam may be used as a foliar treatment during the production of pome fruits. Several use patterns were examined in the supervised trials in the USA on pome fruits (Campbell, 998, ABR-9896): Four foliar applications of WG (water dispersible granule) formulation at rate. The first two are sprays with an application rate of.99 kg ai/ha with an interval of days. The third and fourth applications, as a tank mix with pymetrozine, have an application rate of.49 kg ai/ha, with intervals of and days and a PHI of days. Four foliar applications of WG (water dispersible granule) formulation at rate. The timing is the same as rate. Four foliar applications of WG (water dispersible granule) formulation at 5 rate. The timing is the same as rate. Table 29 Thiamethoxam residues in pome fruits resulting from supervised trials in the USA. Replicate values arise from replicate field samples POME FRUITS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) APPLE USA (PA), 996 WG.99 fruit, mature.8.9 ABR-9896 (Starkrimson Red Delicious) apple +.49 a + 2 E-IR-8-96 USA (Y), 996 (Golden Delicious) apple USA (MI), 996 (Red Delicious) apple USA (OH), 996 (Summer Treat MA root stock) apple USA (CO), 996 (Golden Delicious) apple USA (ID), 996 (Red Delicious) apple USA (OR), 996 (ewtown Pippen) apple WG a WG a WG a WG a WG a WG a fruit, mature.5. ABR-9896 E-IR-8-96 fruit, mature..4 ABR-9896 E-IR-2-96 fruit, mature.4.2 ABR-9896 E-IR-- 96 fruit, mature..4 ABR-9896 MW-IR- -96 fruit, mature.5.9 ABR-9896 W-IR-6-96 fruit, mature.5.8 ABR-9896 W-IR

66 852 Thiamethoxam POME FRUITS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) USA (WA), 996 WG fruit, mature.5.2 ABR-9896 (Braeburn) apple +.49 a + 2 W-IR-6-96 USA (WA), 996 WG (Red Delicious) apple +.49 a + 2 USA (WA), 996 WG (Red Delicious) apple +.5 a + 2 USA (WA), 996 WG (Red Delicious) apple +.25 a + 2 USA (WA), 996 WG (Red Delicious) apple +.49 a + 2 USA (WA), 996 WG (Red Delicious) apple +.5 a + 2 USA (WA), 996 WG (Red Delicious) apple +.25 a + 2 USA (CA), 996 WG (Granny Smith) apple +.49 a + 2 USA (CA), 996 (Rome) apple USA (C), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple WG a WG a WG a WG. +.5 a WG a WG a WG. +.5 a WG a USA (CA), 2 SL.99 2 (Granny Smith) apple 8d USA (CA), 2 WG.99 2 (Granny Smith) apple 8d 5 fruit, mature.8.8 ABR-9896 W-IR fruit, mature.9. ABR-9896 W-IR fruit, mature ABR-9896 W-IR apples.2.2 ABR-9896 W-IR apples.2.2 ABR-9896 W-IR apples.68.5 ABR-9896 W-IR fruit, mature.4.6. ABR-9896 W-IR fruit, mature.2. ABR-9896 W-IR fruit, mature fruit fruit fruit fruit fruit, mature fruit, mature ABR-9896 S-IR-6-96 ABR IR-4-96 fruit, mature.8.. ABR IR-4-96 fruit, mature.6.6 ABR IR-4-96 apples.5 ABR IR-4-96 apples. ABR IR-4-96 apples.5 ABR IR fruit fruit fruit, mature fruit, mature fruit fruit fruit, mature fruit, mature TR TR Apples. 2-TR-2-. Side-by-side trials to compare residue levels from the use of a WG formulation and a SL formulation.

67 Thiamethoxam 85 POME FRUITS Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) PEAR USA (Y), 996 WG fruit, mature..4.. ABR-9896 (Clapp's Favorite) +.49 a + 2 E-IR-85- pears USA (CA), 996 (Bartlett) pear USA (OR), 996 (Anjou) pear USA (WA), 996 (Bartlett) pear USA (WA), 996 (Bartlett) pear USA (CA), 996 (Bartlet) pear WG a WG a WG a WG a WG a a Applied as a tank mix with pymetrozine. 2 fruit fruit fruit fruit fruit, mature fruit, mature ABR IR-4-96 fruit, mature ABR-9896 W-IR-6-96 fruit, mature ABR-9896 W-IR fruit, mature ABR-9896 W-IR-6-96 fruit, mature..2. ABR-9896 W-IR Two formulations may be used in foliar application of thiamethoxam during the production of plums: WG, water dispersible granules and SL, soluble concentrate (Moore and Ediger, 22, 64). The use pattern is: two applications of.96 kg ai/ha with an interval of days and a PHI of days. The same use pattern applied to the production of peaches and cherries. Table Thiamethoxam residues in plums resulting from supervised trials in the USA. Replicate values arise from replicate field samples PLUM Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (MI), 2 (Early Golden) WG d fruit IR4S22 USA (CA), 2 (Santa Rosa) WG.96 2 d fruit IR4S4 USA (CA), 2 (Santa Rosa) SL.96 2 d fruit IR4S4 USA (CA), 2 (Blue Sugar French) WG d fruit IR4S4 USA (OR), 2 (Italian) WG d fruit IR4S68 USA (OR), 2 (Italian) SL d fruit IR4S68 USA (CA), 2 (French) WG.96 2 d fruit fruit to dry prune IR4S USA (CA), 2 (French) WG.4 2 d fruit fruit to dry prune IR4S E-IR ABR This trial is confirmed as a pear trial. "Apple" or "apples" appearing in the text or tables are typographical errors.

68 854 Thiamethoxam PLUM Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (CA), 2 (French) WG d fruit fruit to dry prune IR4S48 USA (CA), 2 (French) WG d fruit fruit to dry prune IR4S48 Table Thiamethoxam residues in peaches resulting from supervised trials in the USA. Replicate values arise from replicate field samples PEACH Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (J), 2 (Dixy Red) WG d fruit IR4S5 USA (Y), 2 (Harcrest) WG d fruit IR4S66 USA (SC), 2 (Red Globe) WG d fruit IR4S USA (SC), 2 (Red Globe) SL d fruit IR4S USA (C), 2 (Biscoe) WG d fruit IR4S2 USA (MI), 2 (Elberta) WG d fruit IR4S5 USA (TX), 2 (Tex Star) WG d a fruit IR4S4 USA (CA), 2 (Flamecrest) WG d IR4S8 2 fruit USA (CA), 2 (Flamecrest) SL d fruit IR4S8 USA (CA), 2 (September Sun) WG d fruit IR4S6 USA (CA), 2 (Loadell) WG d fruit IR4S9 a US label restraint: minimum interval between applications: days. Table 2 Thiamethoxam residues in cherries resulting from supervised trials in the USA. Replicate values arise from replicate field samples CHERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water (L/ha) no. interval days thiamethoxam a CGA 224 a USA (MI), 2 (Hedeffmyer) sweet cherry WG d fruit IR4S USA (CA), 2 (Bing) sweet cherry WG.96 2 d USA (CA), 2 (Bing) sweet cherry SL.96 2 d USA (WA), 2 WG (Bing) sweet cherry d USA (WA), 2 SL (Bing) sweet cherry d 5 22 fruit IR4S 5 fruit IR4S fruit IR4S5 fruit IR4S5

69 Thiamethoxam 855 CHERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water (L/ha) no. interval days thiamethoxam a CGA 224 a USA (OR), 2 (Royal Anne) sweet cherry WG d fruit IR4S8 USA (MI), 2 (Montmorency) tart cherry USA (MI), 2 (Montmorency) tart cherry USA (MI), 2 (Montmorency) tart cherry USA (CO), 2 (Montmorency) tart cherry a c: sample from control plot WG d WG d WG d WG d fruit.8.22 c.2. c IR4S2 fruit IR4S2 fruit IR4S9 fruit IR4S6 Table Thiamethoxam residues in cherries resulting from supervised trials in France, Italy, Spain and Switzerland CHERRIES Application PHI Commodity b Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. Days thiamethoxam CGA 224 a (L/ha) interval fruit flesh fruit flesh France, 25 WG.4 2 (Montmorency) d and flesh France, 25 (Chatel Morel) France, 25 (Obiska) France, 24 (Summit) France, 24 (Summit) France, 26 (Chatel Morel) WG d WG d WG d WG d WG d and flesh and flesh and flesh and flesh and flesh AF/864/SY/ 5-46 AF/864/SY/2 5-4 AF/8642/SY/ CEMS-2 CEMS-2 T64-6- REG AF//SY/ duplicate trial

70 856 Thiamethoxam CHERRIES Application PHI Commodity b Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. Days thiamethoxam CGA 224 a (L/ha) interval fruit flesh fruit flesh France, 26 WG. 6 2 (Chatel Morel) + 8 d and flesh France, 26 (Orhin acide) France, 26 (Orhin acide) France, 26 (Oblasinska) France, 26 (Oblasinska) Italy, 24 (Sweet cherry) Italy, 24 (Sweet cherry) Italy, 25 (Lapins) Italy, 25 (ero ) Spain, 24 (Burlat) WG d WG d WG d WG. 6 2 d WG d WG d WG d WG d WG d and flesh and flesh and flesh and flesh and flesh and flesh and flesh and flesh and flesh T64-6- REG AF//SY/ duplicate trial T REG AF/2/SY/ duplicate trial T REG AF/2/SY/ duplicate trial T REG AF/2/SY/2 duplicate trial T REG AF/2/SY/2 duplicate trial CEMS-2444 AF/829/SY/ CEMS-2444 AF/829/SY/ 5-56 IT-IR IT-IR-5-44 CEMS-2 ES-IR-4-64

71 Thiamethoxam 85 CHERRIES Application PHI Commodity b Residue, mg/kg Ref country, Form kg ai/hakg ai/hlwater no. Days thiamethoxam CGA 224 a (L/ha) interval fruit flesh fruit flesh Spain, 24 (Burlat) WG d and flesh Spain, 25 (Monzon) Switzerland, 24 (Hedelfinger) Switzerland, 24 (Hedelfinger) Switzerland, 25 (Burlat) Switzerland, 25 (Hedelfinger) WG.5 2 d WG d WG d WG d WG d a PHI. -Sample taken just before the final application. and flesh and flesh and flesh and flesh and flesh b Residues were measured in the cherry flesh and calculated on including stone. CEMS-2 ES-IR AF/8642/SY/2 CEMS-229 CEMS CH-IR CH-IR-5-6 Thiamethoxam may be used as a soil treatment or in foliar applications during the production of strawberries. Two use patterns were examined in the supervised trials in the USA on strawberry (Ediger, 2, -): Single directed drench application of SL (soluble concentrate) formulation to the soil at the base of the strawberry plants at.22 kg ai/ha, with harvest or 5 days after the application. At a minimum 2 gallons per acre (8 L/ha), this use pattern simulated drip irrigation application. Three directed foliar applications of WG (water dispersible granule) formulation at.4 kg ai/ha and minimum spray volume of 2 L/ha with intervals of days and harvest,, and days after the final application.

72 858 Thiamethoxam Table 4 Thiamethoxam residues in strawberries resulting from supervised trials in the USA. Replicate values arise from replicate field samples STRAWBERRY Application a PHI Commodity Residue, mg/kg ote b Ref country, Form kg ai/ha water no. and days thiamethoxam CGA 224 (L/ha) interval USA (FL), 2 (Camarosa) SL.22 drench USA (C), 2 (Camarosa) USA (OR), 2 (Selva) USA (CA), 2 (Seascape) USA (CA), 2 (Driscoll E-26) USA (Y), 2 (All Star) USA (CA), 2 (Irvine) USA (MI), 2 (Lester) USA (FL), 2 (Camarosa) USA (C), 2 (Camarosa) USA (OR), 2 (Selva) USA (CA), 2 (Seascape) USA (CA), 2 (Driscoll E-26) SL.22 drench SL.22 drench SL.22 drench SL.22 drench SL.22 drench SL.22 drench SL.22 drench WG.8, 9d WG.8 2 9, d WG.8 d WG.8 4 d WG.8, d fruit fruit..9.. fruit. fruit. fruit fruit..2.2 fruit fruit fruit fruit fruit fruit fruit <. (2) - FL-IR-4- /FL - S-IR-62- /C - W-IR-6- /OR - W-IR-9- /CA - W-IR-9- /CA - E-IR-8- /Y - W-IR-92- /CA - E-IR-- /MI - FL-IR-4- /FL - S-IR-62- /C - W-IR-6- /OR - W-IR-9- /CA - W-IR-9- /CA

73 Thiamethoxam 859 STRAWBERRY Application a PHI Commodity Residue, mg/kg ote b Ref country, Form kg ai/ha water no. and days thiamethoxam CGA 224 (L/ha) interval USA (Y), 2 (All Star) WG.8, 2d USA (CA), 2 (Irvine) USA (MI), 2 (Lester) WG.8 8, 9d WG.8 26, 2d 8 fruit fruit fruit E-IR-8- /Y - W-IR-92- /CA - E-IR-- /MI a drench: directed drench application to simulate drip irrigation application. b In study -, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 5 Thiamethoxam residues in cranberries resulting from supervised trials in the USA CRABERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. and days thiamethoxam CGA 224 (L/ha) interval USA (MA), 2 (Early Black) WG. d cranberry 54 -MA USA (J), 2 (Early Black) WG.4 9, 6d cranberry 54 -J USA (WI), 2 (Ben Lear) WG.4, 6d cranberry 54 -WI8 USA (WI), 2 (Ben Lear) WG.4, 6d cranberry 54 -WI9 USA (OR), 2 (Stevens) WG.4 92 d cranberry 54 -OR9 USA (OR), 2 (Stevens) WG.4 92, 6d cranberry 54 -OR2 Thiamethoxam may be used as a soil treatment or in foliar applications during the production of blueberries. Two use patterns were examined in the supervised trials in the USA on blueberries (Barney, 2, 5). Three directed foliar applications of WG (water dispersible granule) formulation at.4 kg ai/ha with intervals of days and a PHI of days. One soil-applied surface band of SL (soluble concentrate) formulation at.22 kg ai/ha followed by at least 25 mm of irrigation, growth stage: green tip to pink bud. Table 6 Thiamethoxam residues in blueberries resulting from supervised trials in the USA. Duplicate values arise from duplicate field samples BLUEBERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha a water no. and days thiamethoxam CGA 224 (L/ha) interval USA (MI), 2 SL.22 soil 4 86 fruit 5 MI4 (Rubel) USA (MI), 2 SL.2 soil 94 fruit 5 MI5 (Rubels) USA (MI), 2 SL.22 soil 4 94 fruit 5 MI6 (Rubels) USA (C), 2 (Croatan) SL.22 soil 8 fruit 5 C22

74 86 Thiamethoxam BLUEBERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha a water no. and days thiamethoxam CGA 224 (L/ha) interval USA (J), 2 SL.22 soil 2 6 fruit 5 J (Duke) USA (J), 2 SL.2 soil 2 2 fruit 5 J29 (Blueray) USA (OR), 2 SL.24 soil 9 85 fruit 5 OR2 (Bluecrop) USA (ME), 2 WG.4 2 fruit ME5 (Lowbush) 6, d USA (MI), 2 WG.4 4 fruit..6 5 MI4 (Rubel) d USA (MI), 2 WG.4 46 fruit.. 5 MI5 (Rubels) d USA (MI), 2 (Rubels) WG , 6d fruit MI6 USA (C), 2 (Croatan) USA (C), 2 (Blue Chip) USA (J), 2 (Duke) USA (J), 2 (Blueray) USA (OR), 2 (Bluecrop) a soil: soil application. WG.4 29 d WG.4, 6d WG.4 9 6, d WG.4 9 6, d WG , d fruit C22 fruit C2 fruit J fruit J29 fruit 5 OR2 Table Thiamethoxam residues in caneberries resulting from supervised trials in the USA. Duplicate values arise from duplicate field samples CAEBERRY Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. and days thiamethoxam CGA 224 (L/ha) interval USA (J), 22 WG fruit (Canby), red raspberry 6d J USA (OR), 22 (Meeker), raspberry WG d fruit OR8 USA (OR), 22 (Marion), blackberry WG d fruit OR9 USA (WA), 22 (Meeker), raspberry WG.5 2 d fruit WA USA (CA), 22 Boysenberry WG.5 2 d fruit CA6 USA (MI), 22 (Heritage) raspberry WG d fruit MI2 Table 8 Thiamethoxam residues in grapes resulting from supervised trials in France, Italy, Spain and Switzerland GRAPES Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval France, 2 (Cabernet WG d 52 Sauvignon SO4) d 2 2 berries

75 Thiamethoxam 86 GRAPES Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval France, 2 (Cabernet Sauvignon SO4) WG d 2 2 berries (2).2 52 France, 2 (Pinot oir) France, 2 (Pinot oir) France, 22 (Cabernet Franc) France, 22 (Cabernet Franc) France, 22 (Cabernet Franc) France, 22 (Cabernet Franc) red France, 22 (Carignan R) France, 22 (Carignan R) France, 22 (Grenache, red) France, 22 (Meunier) France, 22 (Meunier) France, 22 (Meunier) France, 26 (Cabernet Sauvignon) WG.5.55 WG WG WG WG d 2d d d 2d 2d 2d 2d 2d 2d WG.5 5 2d 2d WG d 2d WG d d WG.5 2d 2d WG.5 5 2d 22d WG.5 5 2d 22d WG d 22d WG d 2 d berries.2 (2) berries.2 berries berries berries berries berries berries berries berries berries berries. (2) berries berries berries.2 grapes, bunches (2) (2) (2) (2) (2) (2) (2) T98-6 FR-IR-6-22 "Les Crespys"

76 862 Thiamethoxam GRAPES Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval France, 26 (Cabernet Sauvignon) WG d 2 d grapes, bunches. T98-6 FR-IR-6-2 plot 2. "Chateau la Capelle" France, 26 (Carignan) France, 26 (Chardonnay) France, 26 (Chardonnay) France, 26 (Muscadet) France, 26 (Muscadet) France, 26 (Syrah) Italy, 2 (Vittoria) table grapes Spain, 2 (Tempranillo) Spain, 2 (Tempranillo) WG.5 2 d WG WG WG WG d 22 d 2 d 22 d 2 d 2 d 22 d 2 d WG.5 2 d WG.5.5 9d d WG d 2d WG. ote d Spain, 22 WG.5 46 (Cariñena, red) Spain, 22 (Palomino) white 2d 2d WG d 2d grapes, bunches bunches, grapes bunches, grapes bunches, grapes bunches, grapes grapes, bunches berries berries berries berries.25.. berries T98-6 FR-IR-6-2 "L'Houmet" T9-6 FR-IR-6-2 "Jaille".2 T9-6 FR-IR-6-26 "La Prole" T9-6 FR-IR-6- "Bonneau" T9-6 FR-IR-6-29 plot 2 "Les quatre routes".2 T98-6 FR-IR-6-2 "Campagnole" (2) <.2 (2) (2) <.2 (2) / 65/ Trial 65/ Trial Osborne, 22, 65/ Trial 2. A check on the field raw data showed that the concentration was.2 kg ai/hl, not. kg ai/hl as reported in the study.

77 Thiamethoxam 86 GRAPES Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval Switzerland, 2 (Chasselas) WG.5 4 d d / Switzerland, 2 (Pinot oir) Switzerland, 22 (Chasselas) Switzerland, 22 (Chasselas) Switzerland, 22 (Pinot oir) Switzerland, 26 (Chasselas) Switzerland, 26 (Chasselas) WG.5 d d WG.5 5 2d 22d WG.5 5 2d 22d WG.5 5 2d 2d WG.5 WG d 22 d 2 d 22 d berries berries berries.6.2 (2) (2) / 2-2 berries 2-2 berries berries juice pomace wine bunches, grapes bunches, grapes.6 (2) (2) (2) (2) <. (2) 2-6. T9-6 CH-IR-6-25 "Grand Blettay" T9-6 CH-IR-6-24 "Le Sac" Thiamethoxam may be used as a basal treatment during the production of bananas. Such a use pattern was examined in the supervised trials in Cameroon on bananas (Franceschi, 2, 269): The product was applied at.2 or.4 g ai/banana clump in an application volume of ml by knapsack. The solution was applied around the clump source generally covering the mother and the most advanced sucker. Table 9 Thiamethoxam residues in bananas resulting from supervised trials in Cameroon 2 BAAAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai per clump no. days thiamethoxam CGA 224 interval Cameroon, 22 WG.2 g ai per -2 (Grande naine) banana clump a 2d Cameroon, 22 (Grande naine) Cameroon, 22 (Grande naine) Cameroon, 22 (Grande naine) WG WG WG g ai per banana clump a g ai per banana clump a 24.2 g ai per banana clump a 2 88d

78 864 Thiamethoxam BAAAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai per clump no. days thiamethoxam CGA 224 interval Cameroon, 22 (Grande naine) WG g ai per banana clump a pulp pulp pulp pulp pulp peel a Directed application, ml of spray liquid applied around the clump source, generally covering the mother and most advanced sucker. Thiamethoxam may be used as a drench treatment during the production of mangoes. A drench use pattern was examined in the supervised trials in South Africa on mangoes (Labuschagne, 24, I 24 ZA): The product was applied at.4 or 2.9 g ai/tree as a drench in an application volume of litre. A jug was used to pour the application liquid around the base of the trees. Treatment was in August, with harvest of mature fruit anticipated in early to mid-summer. Table 4 Thiamethoxam residues in mangos resulting from supervised trials in South Africa MAGO Application PHI Commodity Residue, mg/kg Ref country, Form no. days thiamethoxam c CGA 224 interval South Africa (Limpopo), 24 (Tommy Atkins) SL 2 4/4 South Africa (Limpopo), 24 (Tommy Atkins) South Africa, 2 (Kent) South Africa, 2 (Kent) South Africa, 2 (Kent) South Africa, 2 (Kent) South Africa (Limpopo), 2 (Keitt) SL SL SL SL SL SL.4 g ai/tree drench a Skin + flesh b (2) g ai/tree Skin + flesh b.9.9 (2) 4/4 drench a g ai/tree 6 Skin + flesh b.4.4 (2) 4/9 drench a 2.9 g ai/tree 6 Skin + flesh b.8. (2) 4/9 drench a.4 g ai/tree drench a g ai/tree drench a Skin + flesh b c Skin + flesh b c /8 4/8.4 g ai/tree 5 Skin + flesh b (2).2.2 4/4 drench a.2 c.2 c 2 van Zyl, 25, 4/4 trial on mango. The formulation is described in the study as an SC. It is a soluble concentrate, SL. Presumably this applies to the other South African trials too.

79 Thiamethoxam Skin + flesh b /4 MAGO Application PHI Commodity Residue, mg/kg Ref country, Form no. days thiamethoxam c CGA 224 interval South Africa SL 2.9 g ai/tree (Limpopo), 2 (Keitt) drench a.2 c.2 c a Drench application of litre of water per tree, poured around the base of the tree. b A homogeneous mixture of skin+flesh was analysed. Residue concentrations are probably expressed on skin+flesh, because there is no explicit statement that residues are expressed on. c sample from control plot. Thiamethoxam may be used as a drench treatment during the production of papaya. A drench use pattern was examined in the supervised trials in Brazil on papaya (Krainz, 2, 2-6): The product was applied at.2 or.4 kg ai/ha as a drench around each tree. A syringe was used to dispense the application liquid at ml/tree (equivalent to 5 litres per hectare) at 2 cm from the trunk on bare soil. Table 4 Thiamethoxam residues in papaya resulting from supervised trials in Brazil and Côte d'ivoire PAPAYA Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval Brazil (ES), 22 (Golden) 2-6 Brazil (ES), 22 (Golden) Brazil (BA), 22 (Golden) WG.2 kg ai/ha drench a 5 WG.4 kg ai/ha drench a 5 WG.2 kg ai/ha 8 drench a peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b <. <

80 866 Thiamethoxam PAPAYA Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval Brazil (BA), 22 (Golden) 2-62 Brazil (ES), 22 (Golden) Brazil (ES), 22 (Golden) Brazil (ES), 22 (Taiwan) WG.4 kg ai/ha drench a WG.2 kg ai/ha drench a 96 WG.4 kg ai/ha 96 drench a WG.2 kg ai/ha 59 drench a peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b peel pulp b <. <

81 Thiamethoxam 86 PAPAYA Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval Brazil (ES), 22 (Taiwan) 2-6 Côte d'ivoire, 24 (Golden) Tiassalé. c Côte d'ivoire, 24 (Golden) Azaguié. c WG.4 kg ai/ha drench a 65 WG.2 kg ai/hl, 5 ml per tree as a drench at base of trunk WG.2 kg ai/hl, 5 ml per tree as a drench at base of trunk d 2 d 2 peel pulp b peel pulp b peel pulp b peel pulp b a Drench application at. litre of water per tree, around the trunk. b Residues in calculated from residues in peel and pulp. c CIV/CRA/PA/24. o analytical report or analytical method available. CIV/CRA/PA/24 CIV/CRA/PA/24 Table 42 Thiamethoxam residues in pineapples resulting from supervised trials in Brazil PIEAPPLE Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hlno. days thiamethoxam CGA 224 interval Brazil (SP), 25 (Havaiano) WG M4-LZF Brazil (MG), 25 (Havaiano) Brazil (MG), 25 (Havaiano) Brazil (MG), 25 (Havaiano) WG WG WG.2.2 a.2.2 a.2.2 a.2.2 a.5 6d various d 5 various d 5 various d 5 various 45 6 fruit fruit fruit fruit M4-JJB M4-JJB2 M4-JJB a Treatment : seedlings with.5 kg ai/hl. Treatments 2 and : row drench at.2 kg ai/ha. Interval between treatments and 2: 6 days. Interval between treatments 2 and : various intervals, so that fruit with various PHIs were harvested at maturity. Thiamethoxam may be used as an in-furrow spray, a surface band incorporated or a transplant drench at planting, and in foliar applications during the production of Brassica vegetables. Four use

82 868 Thiamethoxam patterns were examined in the supervised trials on broccoli, mustard greens and cabbage in the USA (Campbell, 998, ABR-985): Two foliar sprays of WG (water dispersible granules) formulation at.99 kg ai/ha with a days interval and a days PHI. Application as an in-furrow spray of SL (soluble concentrate) formulation at. kg ai/ha at planting, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Application as a narrow surface band soil-incorporated, of SL (soluble concentrate) formulation at. kg ai/ha at planting, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Transplant drench at. kg ai/ha, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Table 4 Thiamethoxam residues in Brassica vegetables resulting from supervised trials in the USA. Replicate values arise from replicate field samples BRASSICA VEG Application PHI Commodity a Residue, mg/kg Ref country, Form kg ai/ha b water no. days thiamethoxam c CGA 224 c (L/ha) interval BROCCOLI USA (CA), 2 SL head + stem TR- (Greenbelt), broccoli d 4-/CA d USA (CA), 2 WG head + stem TR- (Greenbelt), broccoli d 4-/CA d USA (TX), 2 (Buccaneer), broccoli SL.99 2 d head + stem S-TR- -/TX d USA (TX), 2 (Buccaneer), broccoli WG.99 2 d USA (CA), 99 (de WG.99 2 Cicco) broccoli d USA (CA), 99 (de SL. dr 4 Cicco) broccoli WG.49 USA (TX), 99 WG (Southern Comet) d broccoli USA (TX), 99 (Southern Comet) broccoli USA (CA), 99 (Patriot) broccoli USA (CA), 99 (Patriot) broccoli USA (AZ), 99 (Marithon) broccoli USA (AZ), 99 (Marithon) broccoli USA (OR), 99 (Packman) broccoli USA (OR), 99 (Packman) broccoli USA (CA), 99 (Patriot) broccoli USA (CA), 99 (Patriot) broccoli SL WG. dr WG d SL. dr 68 WG WG d SL. dr 4 WG.49 2 WG d SL. dr 522 WG.49 2 WG d SL WG. dr head + stem S-TR- -/TX d broccoli broccoli broccoli broccoli broccoli..9.. broccoli broccoli broccoli.9.4 broccoli broccoli broccoli broccoli <. (2). ABR IR-4-9 ABR IR-4-9 ABR-985 S-IR-4-9 ABR-985 S-IR-4-9 ABR-985 W-IR-52-9 ABR-985 W-IR-52-9 ABR-985 W-IR-5-9 ABR-985 W-IR-5-9 ABR-985 W-IR-6-9 ABR-985 W-IR-6-9 ABR-985 W-IR-5-9 ABR-985 W-IR-5-9

83 Thiamethoxam 869 BRASSICA VEG Application PHI Commodity a Residue, mg/kg Ref country, Form kg ai/ha b water no. days thiamethoxam c CGA 224 c (L/ha) interval MUSTARD GREES USA (CA), 2 (Florida Broadleaf), mustard greens SL.99 2 d leaves W- TR-9-/CA d USA (CA), 2 (Florida Broadleaf), mustard greens USA (CA), 998 (Florida Broadleaf) mustard greens USA (CA), 998 (Florida Broadleaf) mustard greens USA (CA), 998 (Florida Broadleaf) mustard greens USA (IL), 99 (Southern Giant Curled) mustard greens USA (IL), 99 (Southern Giant Curled) mustard greens USA (IL), 99 (Southern Giant Curled) mustard greens USA (GA), 99 (Southern Giant Curled) mustard greens USA (GA), 99 (Southern Giant Curled) mustard greens USA (GA), 99 (Southern Giant Curled) mustard greens USA (TX), 99 (Florida Broadleaf) mustard greens USA (TX), 99 (Florida Broadleaf) mustard greens USA (TX), 99 (Florida Broadleaf) mustard greens USA (LA), 99 (Florida Broadleaf) mustard greens USA (LA), 99 (Florida Broadleaf) mustard greens WG.99 2 d WG d SL WG SL WG. if.49. sb WG d SL WG SL WG. if.49. sb WG.99 2 d SL WG SL WG. if.49. sb.49 WG d SL WG SL WG. if.49. sb WG d SL WG. if.49 2 leaves W- TR-9-/CA d 6 9 leaf c.2. c..2 leaf c.2. c..2 leaf c.2. c..2 leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf c.2 leaf c c.. c c.. c c.. c c c ABR IR-5-9 ABR IR-5-9 ABR IR-5-9 ABR IR--9 ABR IR--9 ABR IR--9 ABR-985 S-IR-82-9 ABR-985 S-IR-82-9 ABR-985 S-IR-82-9 ABR-985 S-IR-6-9 ABR-985 S-IR-6-9 ABR-985 S-IR-6-9 ABR-985 S-IR-92-9 ABR-985 S-IR-92-9

84 8 Thiamethoxam BRASSICA VEG Application PHI Commodity a Residue, mg/kg Ref country, Form kg ai/ha b water no. days thiamethoxam c CGA 224 c (L/ha) interval USA (LA), 99 SL. sb leaf ABR-985 (Florida Broadleaf) WG mustard greens c c S-IR-92-9 CABBAGE USA (Y), 2 (Augusta), cabbage USA (Y), 2 (Augusta), cabbage USA (CA), 99 (Copenhagen) cabbage USA (CA), 99 (Copenhagen) cabbage USA (FL), 99 (Bravo) cabbage USA (FL), 99 (Bravo) cabbage USA (TX), 99 (Gensis) cabbage USA (TX), 99 (Gensis) cabbage USA (C), 99 (Blue Thunder) cabbage USA (C), 99 (Blue Thunder) cabbage USA (WI), 99 (Vantage Point) cabbage USA (WI), 99 (Vantage Point) cabbage SL d WG d WG.99 2 d SL WG. dr.49 4 WG d SL WG. dr WG d SL WG. dr WG d SL WG. dr WG d SL WG. dr head + wl head only wl only head + wl head only wl only Head + wl c. c head only....4 Head + wl c. c head only.6.5 c Head + wl c head only.2 Head + wl c head only Head + wl head only Head + wl head only Head + wl c. head only..2 Head + wl.2... c. head only..6 Head + wl head only head+wl head only c c c c.2.. c..2. c. c <. (2) c..2. c TR- 2-/Y d 2-.5-TR- 2-/Y d ABR IR-4-9 ABR IR-4-9 ABR-985 -IR--9 ABR-985 -IR--9 ABR-985 S-IR-5-9 ABR-985 S-IR-5-9 ABR-985 S-IR-65-9 ABR-985 S-IR-65-9 ABR-985 MW-IR-2-9 ABR-985 MW-IR-2-9

85 Thiamethoxam 8 BRASSICA VEG Application PHI Commodity a Residue, mg/kg Ref country, Form kg ai/ha b water no. days thiamethoxam c CGA 224 c (L/ha) interval USA (Y), 99 WG (Rio Verde) cabbage d USA (Y), 99 SL (Rio Verde) cabbage WG. dr Head + wl c head only.. Head + wl c head only c.2. c.2 ABR-985 E-IR-89-9 ABR-985 E-IR-89-9 a wl: wrapper leaves. b if: in-furrow treatment at planting. c c: sample from control plot. d Side-by-side trials to provide bridging data that compare residues found when using WG (water dispersible granules) and SL (soluble concentrate) formulations. e In study ABR-985, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. sb: soil surface band treatment at planting, incorporated. dr: drench treatment at transplanting. Thiamethoxam may be used as a soil treatment at sowing or in foliar applications during the production of cucurbit fruiting vegetables. Three use patterns were examined in the supervised trials on cucumbers, cantaloupe and summer squash in the USA (Eudy, 998, ABR-9885). Two foliar sprays of WG (water dispersible granules) formulation at.99 kg ai/ha with a 4 5 days interval and a days PHI. Application as an in-furrow spray of SL (soluble concentrate) formulation at. kg ai/ha at sowing, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Application as a narrow surface band soil-incorporated, of SL (soluble concentrate) formulation at. kg ai/ha at sowing, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Table 44 Thiamethoxam residues in cucumbers resulting from supervised trials in the USA. Replicate values arise from replicate field samples CUCUMBER Application PHI Commodity Residue, mg/kg b Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval USA (CA), 996 (Dasher II) WG d fruit....4 ABR IR-4-96 USA (CA), 996 (Dasher II) USA (CA), 996 (Dasher II) USA (Fl), 996 (Marketmore 6 SL WG SL WG. if sb WG d fruit fruit..2.. ABR IR-4-96 ABR IR-4-96 fruit..2 ABR IR--96

86 82 Thiamethoxam CUCUMBER Application PHI Commodity Residue, mg/kg b Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval USA (Fl), 996 SL. if 9 fruit.2. ABR-9885 (Marketmore 6) WG IR--96 USA (TX), 996 (Poinsett 6) USA (TX), 996 (Poinsett 6) USA (C), 996 (ational Pickle) WG d SL WG USA (C), SL 996 (ational WG Pickle) USA (C), SL 996 (ational WG Pickle) USA (SC), 996 (Poinsett 6) USA (SC), 996 (Poinsett 6) USA (CA), 996 (Sweet Slice). if WG d.2 if sb WG d SL WG SL WG. if if USA (WI), WG (Fanicpak 5d M) USA (WI), SL 996 (Fanicpak WG M) USA (MI), 996 (Market Moore 6) USA (MI), 996 (Market Moore 6) USA (MI), 996 (Market Moore 6) USA (CA), 99 (Market Moore 6). if WG d SL WG SL WG. if sb WG d fruit.4.4 ABR-9885 S-IR-6-96 fruit.2.2 ABR-9885 S-IR-6-96 fruit.4. ABR-9885 S-IR fruit.. ABR-9885 S-IR fruit.2 ABR-9885 S-IR fruit..5 ABR-9885 S-IR fruit.2. ABR-9885 S-IR fruit.4. ABR-9885 W-IR fruit..8 ABR-9885 MW-IR-4-96 fruit.2. ABR-9885 MW-IR-4-96 fruit.9.4 ABR-9885 E-IR-2-96 fruit. ABR-9885 E-IR-2-96 fruit. ABR-9885 E-IR-2-96 fruit.5.5 ABR-9885 W-IR-4-9 a if: in-furrow treatment at sowing. sb: soil surface band treatment at sowing, incorporated. b In study ABR-9885, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses.

87 Thiamethoxam 8 Table 45 Thiamethoxam residues in cucumbers resulting from supervised trials in France, etherlands and Spain CUCUMBER Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha a kg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval France, 22 (Logica) protected WG. drench 26 2 d 2- etherlands, 24 (Euforia) protected etherlands, 24 (Euforia) protected Spain, 22 (Borja) protected Spain, 22 (Borja) protected Spain, 2 (Dosel) protected Spain, 2 (Sol verde, French type) protected Spain, 25 (Borja) protected, rockwool substrate Spain, 25 (Borja) protected, rockwool substrate Spain, 25 (Sinaloa) protected, cocofibre substrate Spain, 25 (Sinaloa) protected, cocofibre substrate WG. syringe WG.2 syringe WG. drip WG.2 drip WG.2 drip WG.2 drip WG. syringe WG.2 syringe WG. syringe WG.2 syringe. l per plant. l per plant 56 2 d cucumbers cucumbers.8.4 cucumbers..9.2 cucumbers cucumbers cucumbers.6.6. cucumbers.6.9. cucumbers..9. cucumbers cucumbers.4. cucumbers <.2 CEMS-26 CEMS CEMS-2 AF/8/SY/ CEMS-2 AF/8/SY/ CEMS-2 AF/8/SY/2 CEMS-2 AF/8/SY/2 a drip: drip application, adapting the knapsack sprayer to the irrigation system. - drench: application by watering soil around plants. - syringe: application, prior to first irrigation, to the base of each plant with a syringe to simulate a drip application.

88 84 Thiamethoxam Table 46 Thiamethoxam residues in melons resulting from supervised trials in Italy and Spain MELO Application PHI Commodity Residue, mg/kg Ref country, Formkg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval Italy, 22 WG (Baggio) protected drench d Italy, 22 WG. (Baggio) protected drench Spain, 22 (Galia) protected Spain, 22 (Galia) protected Spain, 22 (Solarquin) protected Spain, 22 (Solarquin) protected Spain, 2 (Aurabel, cantaloupe type) protected WG. drip WG.2 drip WG. drip WG.2 drip WG.2 drip 56 2 d 25 2 d d pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel b pulp peel pulp peel

89 Thiamethoxam 85 MELO Application PHI Commodity Residue, mg/kg Ref country, Formkg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval Spain, 2 (Campiño) protected WG.2 drip pulp peel pulp peel.4.5 a drench: application of ml per plant from a measuring jug or graduated syringe into the root zone. - drip: drip application, adapting the knapsack sprayer to the irrigation system. b residues in calculated from residues in pulp and peel. Table 4 Thiamethoxam residues in cantaloupes resulting from supervised trials in the USA. Replicate values arise from replicate field samples CATALOUPE Application PHI Commodity Residue, mg/kg b Ref country, Formkg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval USA (CA), 996 SL. if 94 fruit.4. ABR-9885 (Hale's Best Jumbo) WG IR USA (CA), 996 (Hale's Best Jumbo) USA (TX), 996 (Tam Uvaide) USA (TX), 996 (Tam Uvaide) USA (GA), 996 (Hale's Best Jumbo) USA (CA), 996 (Casaba) USA (CA), 996 (Hybrid Top Score) USA (I), 996 (Burpee Hybrid) USA (CA), 996 (Hale's Best Jumbo) USA (TX), 996 (Tam Uvaide) USA (GA), 996 (Hale's Best Jumbo) USA (CA), 996 (Casaba) USA (CA), 996 (Hybrid Top Score) USA (I), 996 (Burpee Hybrid) SL WG. sb +.49 SL. if WG +.49 SL. sb WG +.49 SL. if WG +.49 SL WG SL WG SL WG. if if if WG d WG d WG d WG d WG d WG d fruit ABR IR fruit.2.2 ABR-9885 S-IR--96 fruit..2 ABR-9885 S-IR--96 fruit ABR-9885 S-IR fruit.4.4 ABR-9885 W-IR fruit.. ABR-9885 W-IR fruit.5.2 ABR-9885 E-IR-- 96 fruit ABR IR fruit.4.2 ABR-9885 S-IR--96 fruit..2 ABR-9885 S-IR fruit.6.5 ABR-9885 W-IR fruit..2 ABR-9885 W-IR fruit..9 ABR-9885 E-IR-- 96 a if: in-furrow treatment at planting. - sb: soil surface band treatment at planting, incorporated. b In study ABR-9885, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses.

90 86 Thiamethoxam Table 48 Thiamethoxam residues in summer squash resulting from supervised trials in the USA. Replicate values arise from replicate field samples SUMMER SQUASH country, USA (CA), 996 (Ambassador) Application PHI Commodity Residue, mg/kg b Ref Form kg ai/ha a SL WG USA (CA), 996 SL (Ambassador) WG USA (FL), 996 (Crookneck Early Summer) USA (FL), 996 (Crookneck Early Summer) USA (GA), 996 (Yellow Crookneck) SL WG SL WG SL WG. if sb if sb if +.49 USA (MI), 996 SL. if (Lemondrop L) WG +.49 USA (Y), SL. if 996 (Super WG +.49 Select) USA (CA), 996 (Ambassador) USA (FL), 996 (Crookneck Early Summer) USA (GA), 996 (Yellow Crookneck) kg ai/hl water (L/ha) no. interval days thiamethoxam CGA fruit c.4 c 94 fruit WG d WG d WG d USA (MI), 996 WG (Lemondrop L) 5d USA (Y), WG (Super 5d Select) ABR IR ABR IR c.4 c fruit. ABR IR-2-96 fruit ABR IR-2-96 fruit.6.9 ABR-9885 S-IR fruit.. ABR-9885 E-IR-2-96 fruit.2.2 ABR-9885 E-IR-8-96 fruit c c.4 c c ABR IR fruit.2.2 ABR IR-2-96 fruit.5.5 ABR-9885 S-IR fruit.6.5 ABR-9885 E-IR-2-96 fruit.5. ABR-9885 E-IR-8-96 a if: in-furrow treatment at planting. - sb: soil surface band treatment at planting, incorporated. b In study ABR-9885, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 49 Thiamethoxam residues in sweet corn and popcorn resulting from supervised trials with seed treatment uses in the USA. Replicate values arise from replicate field samples SWEET COR Application PHI CommodityResidue, mg/kg a Ref country, Form g ai/kg days thiamethoxam CGA 224 seed USA (CA), 998 (Primetime) FS 4.5 seed treatment 8 ears SR-2-98 USA (IL), 998 (Kandy King) FS 4.5 seed treatment 6 ears SR-8-98 USA (Y), 998 (Kandy King) FS 4.5 seed treatment ears SR-4-98 USA (FL), 998 (Golden Cross Bantam Hybrid) FS 4.5 seed treatment 6 ears SR--98 USA (C), 998 (Kandy King) FS 4.5 seed treatment 6 ears S-SR-65-98

91 Thiamethoxam 8 SWEET COR Application PHI CommodityResidue, mg/kg a Ref country, Form g ai/kg days thiamethoxam CGA 224 seed USA (WA), 998 (Jubilee) FS 4.5 seed treatment 2 ears W-SR USA (WA), 998 (Jubilee) FS. seed treatment 2 ears W-SR USA (OR), 998 (Primetime) FS 4.5 seed treatment 98 ears W-SR-6-98 USA (OR), 998 (Primetime) FS. seed treatment 98 ears W-SR-6-98 USA (WI), 998 (Jubilee) FS 4.5 seed treatment 8 ears MW-SR-2-98 USA (M), 998 (Jubilee) FS 4.5 seed treatment 89 ears MW-SR USA (OH), 998 (Kandy King) FS 4.5 seed treatment 65 ears E-SR POPCOR USA (KS), 998 (M- FS 4.5 seed treatment 4 grain ) popcorn MW-SR-5-98 USA (E), 998 (M- FS 4.5 seed treatment 29 grain ) popcorn MW-SR USA (I), 998 (M- FS 4.5 seed treatment grain ) popcorn MW-SR-8-98 a In study 58-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 5 Thiamethoxam residues in tomatoes resulting from supervised trials in France, Italy, Spain and Switzerland TOMATO Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. Days a thiamethoxam CGA 224 b (L/ha) interval France, 999 (Cencara) greenhouse WG d /99 France, 999 (Cencara) greenhouse France, 999 (Tamaris) greenhouse France, 999 (Tamaris) greenhouse Italy, 996 ( Precodor) greenhouse WG d WG d WG d WG.. 2 d - 2 fruit (2) fruit fruit fruit fruit /99 2/99 2/99 98/96

92 88 Thiamethoxam TOMATO Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. Days a thiamethoxam CGA 224 b (L/ha) interval Italy, 996 (Boss) WG d 95/96 Italy, 996 (Gincala) greenhouse Italy, 996 (HP 244) Italy, 99 (986) Italy, 99 (Cuor di bue) greenhouse Italy, 99 (Italdor) Italy, 99 (S Marzano) Italy, 26 (Magnum) Italy, 26 (Magnum) Italy, 26 (Perfect pill) WG d WG d WG d WG.. 2 d WG d WG d SL d WG d SL. 6 2 d fruit..6.2 fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit fruit..2 fruit /96 96/96 8/9 9/96 8/9 8/9 T8-6 AF/9/SY/ T8-6 AF/9/SY/ T8-6 AF/9/SY/4 CGA 224 corrected for procedural recovery (.8).

93 Thiamethoxam 89 TOMATO Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. Days a thiamethoxam CGA 224 b (L/ha) interval Italy, 26 (Perfect pill) WG. 6 2 d Spain, 996 (Durinta) Spain, 996 (Royesta) greenhouse Spain, 99 (H 889) Spain, 99 (Rento) Spain, 99 (Suan) Spain, 999 (Genaro) greenhouse Spain, 999 (Genaro) greenhouse Spain, 999 (Genaro) greenhouse Spain, 999 (Genaro) greenhouse Spain, 22 (Julia) protected Spain, 22 (Julia) protected WG d WG d WG d WG d WG d WG d WG d WG d WG d WG. 2 2 d WG.2 drip - 2 fruit.8 T8-6 AF/9/SY/4-2 fruit.2 <.2 9/96 - fruit.5 8/ note 4. fruit (2) (2) 2/9 fruit (2) (2) 69/96 fruit (2) (2) / fruit fruit fruit fruit fruit fruit /99 26/99 25/99 25/ Tomato, 8/96. Residues of thiamethoxam and CGA 224 on days and 2 confirmed by second analysis.

94 88 Thiamethoxam TOMATO Application PHI Commodity Residue, mg/kg Ref country, Form kg ai/ha kg ai/hl water no. Days a thiamethoxam CGA 224 b (L/ha) interval Spain, 26 (Manitu) SL. 2 d Spain, 26 (Manitu) Spain, 26 (Tina) Spain, 26 (Tina) Switzerland, 996 (Durina) Switzerland, 996 (Paola) Switzerland, 99 (Cannelli) greenhouse Switzerland, 99 (Durinta) greenhouse WG. 2 d SL. 5 2 d WG. 5 2 d WG d WG d WG d WG d a PHI. - Sample taken just before the final application fruit.6.2 fruit.5. <.2 fruit..5 fruit fruit fruit....2 fruit fruit b drip: drip application, adapting the knapsack sprayer to the irrigation system. T8-6 AF/9/SY/2 T8-6 AF/9/SY/2 T8-6 AF/9/SY/ T8-6 AF/9/SY/ 4/96 /96 2/9 22/9 Thiamethoxam may be used as a soil treatment at planting or in foliar applications during the production of tomatoes and peppers. Several use patterns were examined in the supervised trials in the USA on tomatoes and peppers (Eudy, 998, ABR-985): Two foliar sprays of WG (water dispersible granules) formulation at.99,. or.49 kg ai/ha with a 5 days interval and a days PHI. Application as an in-furrow spray of SL (soluble concentrate) formulation at. kg ai/ha at planting, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI.

95 Thiamethoxam 88 Application as a narrow surface band of SL formulation at. kg ai/ha during planting and incorporation to a depth of approximately 4 mm with irrigation over 24 hours. Follow with a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Application as a transplant drench of SL formulation at. kg ai/ha, followed by a foliar spray of WG formulation at.49 kg ai/ha with a days PHI. Table 5 Thiamethoxam residues in tomatoes, bell peppers and, hot peppers, resulting from supervised trials in the USA. Replicate values arise from replicate field sample FRUITIG VEG Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 ote a (L/ha) interval BELL PEPPERS USA (CA), 996 SL. dr 4 fruit.. ABR-985 (Volo Wonder) bell WG IR-5-96 pepper USA (FL), 996 SL. dr fruit.. ABR-985 (Jupiter) bell pepper WG IR-2-96 USA (TX), 996 (Tam Mild) bell pepper USA (TX), 996 SL WG SL (Capistrano Hybrid) WG bell pepper USA (C), 996 SL (Capistrano) bell WG pepper USA (CA), 996 SL (Calif Wonder) bell WG pepper USA (MI), 996 SL (Jupiter) bell pepper WG USA (CA), 996 (Volo Wonder) bell pepper. dr.49. dr.49. dr.49. dr dr.49 WG d USA (FL), 996 WG.99 2 (Jupiter) bell pepper 5 d USA (TX), 996 (Tam Mild) bell pepper USA (C), 996 (Capistrano) bell pepper WG d WG d USA (CA), 996 (Calif Wonder) bell pepper WG d USA (MI), 996 WG.99 2 (Jupiter) bell pepper 5 d HOT PEPPERS USA (CA), 996 (Fresno Chili) hot pepper SL WG USA (M), 996 SL (Sandia) hot pepper WG USA (M), 996 SL (Sandia) hot pepper WG. dr.49. if.49. sb fruit ABR-985 S-IR fruit ABR-985 S-IR fruit. ABR-985 S-IR fruit.. ABR-985 W-IR-5-96 fruit..2 ABR-985 E-IR fruit.6.5 ABR IR-5-96 fruit ABR-985 -IR-2-96 fruit..8. ABR-985 S-IR fruit.8.8 ABR-985 S-IR fruit..8 ABR-985 W-IR-5-96 fruit.8.4 ABR-985 E-IR fruit ABR IR-5-96 fruit.2.2 ABR-985 S-IR-2-96 fruit.2.2 ABR-985 S-IR-2-96

96 882 Thiamethoxam FRUITIG VEG Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 ote a (L/ha) interval USA (CA), 996 (Fresno Chili) hot pepper WG d USA (TX), 996 hot pepper WG d USA (M), 996 WG.99 2 (Sandia) hot pepper 5 d TOMATOES USA (CA), 2 SL (Ace) tomato d USA (FL), 2 (Solarset) tomato USA (CA), 996 (Calace) tomato SL WG USA (CA), 996 SL (Rio Grande) WG tomato USA (CA), 996 SL (Rio Grande) WG tomato USA (FL), 996 SL (Sunny) tomato WG USA (SC), 996 SL (Celebrity) tomato WG USA (CA), 99 SL (Heinz 55) WG tomato USA (CA), 996 SL (8892) tomato WG USA (CA), 996 SL (8892) tomato WG USA (CA), 996 SL (Peel Mech) tomato WG USA (CA), 996 SL (Peel Mech) tomato WG USA (CA), 996 SL (Peel Mech) tomato WG USA (CA), 996 SL (Peel Mech) tomato WG USA (FL), 996 SL (Better Boy) tomato WG USA (OH), 996 SL (Heinz 95) WG tomato USA (PA), 996 (Celebrity) tomato USA (CA), 2 (Ace) tomato USA (FL), 2 (Solarset) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato SL d. dr.49. if.49. sb dr.49. dr dr dr.49. dr.49. if.49. sb.49. if.49. sb.49. dr.49. dr.49 4?? SL WG. dr WG d WG d WG d WG d fruit ABR IR-5-96 fruit.9. ABR-985 S-IR fruit..6 ABR-985 S-IR fruit...2 fruit fruit.2. fruit.. fruit TR-2-2/ 9- S-TR-82-2/ ABR IR ABR IR ABR IR fruit..2 ABR-985 -IR-9-96 fruit.. ABR S-IR fruit.2.2 ABR-985 W-IR fruit.4.5 ABR-985 W-IR fruit ABR-985 W-IR fruit..5 ABR-985 W-IR fruit.2.2 ABR-985 W-IR fruit.4.6 ABR-985 W-IR fruit..4 ABR-985 W-IR fruit.2.2 ABR-985 FL-IR fruit.6.8 ABR-985 E-IR fruit.6. ABR-985 E-IR fruit TR-2- b fruit S-TR-82- b fruit.5.2 ABR IR-9-9 fruit.4.4 ABR IR-9-9

97 Thiamethoxam 88 FRUITIG VEG Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 ote a (L/ha) interval USA (CA), 996 (Rio Grande) tomato WG d fruit ABR IR-9-9 USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Calace) tomato USA (CA), 996 (Rio Grande) tomato USA (FL), 996 (Sunny) tomato WG d WG d WG d WG d WG d WG d WG d WG d WG d USA (CA), 996 (HP8) tomato WG d USA (CA), 996 WG.99 2 (8892) tomato 5 d USA (CA), 996 WG. 2 (8892) tomato 5 d USA (CA), 996 WG.49 2 (8892) tomato 5 d USA (CA), 996 WG (8892) tomato 5 d USA (CA), 996 WG.99 2 (Peel Mech) tomato 5 d USA (CA), 996 WG.99 2 (Peel Mech) tomato 5 d USA (FL), 996 WG.99 2 (Better Boy) tomato 5 d USA (OH), 996 WG (Heinz 95) 5 d tomato USA (PA), 996 WG (Celebrity) tomato 5 d USA (SC), 996 WG (Celebrity) tomato 5 d USA (CA), 996 (8892) tomato WG d fruit.. ABR IR-9-9 fruit.6.9 ABR IR-9-9 fruit ABR IR-9-9 fruit.. ABR IR-9-9 fruit.2. ABR IR-9-9 fruit ABR IR-9-9 fruit ABR IR fruit ABR IR fruit.4 ABR IR fruit.6.8 ABR-985 W-IR fruit ABR W-IR fruit ABR W-IR fruit ABR W-IR fruit.6. ABR-985 W-IR fruit.... ABR-985 W-IR fruit.4.5 ABR-985 W-IR fruit.4. ABR-985 FL-IR fruit.2. ABR-985 E-IR fruit ABR-985 E-IR fruit.. ABR S-IR fruit, process..2 ABR-985 W-IR o field reports provided for ABR-985.

98 884 Thiamethoxam FRUITIG VEG Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha water no. days thiamethoxam CGA 224 ote a (L/ha) interval USA (CA), 996 (8892) tomato WG d 9 fruit, process.2.4 ABR-985 W-IR USA (CA), 996 (8892) tomato WG. 2 5 d fruit, process..4 ABR-985 W-IR USA (CA), 996 (8892) tomato WG. 2 5 d 9 fruit, process.2.6 ABR-985 W-IR USA (CA), 996 (8892) tomato WG d fruit, process..4 ABR-985 W-IR USA (CA), 996 (8892) tomato WG d 9 fruit, process..8 ABR-985 W-IR a if: in-furrow treatment at planting. - sb: soil surface band treatment at planting, incorporated. - dr: drench treatment at transplanting. b Side-by-side trial comparing the use of WG (water-dispersible granules) and SL (soluble concentrate) formulations as part of a bridging study for approval of SL uses on fruiting vegetables. c In study ABR-985, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 52 Thiamethoxam residues in sweet peppers resulting from supervised trials in France, Italy, Spain, Switzerland and the UK PEPPERS Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/h water no. days a thiamethoxam CGA 224 L (L/ha) interval France, 999 WG fruits.9 92/99 (Volga) sweet peppers, greenhouse d (2) trial France, 999 (Volga) sweet peppers, greenhouse Italy, 996 (Friarello) sweet peppers, greenhouse Italy, 996 (Friariello) sweet peppers Italy, 996 (Phatos) sweet peppers, greenhouse Italy, 996 (Rex) sweet peppers WG d WG.. 2 d WG.. 2 d WG.. 2 d WG. 2 d fruits fruits fruits fruits fruits (2). 92/99 trial 2 /96 9/96 99/96 94/96

99 Thiamethoxam 885 PEPPERS Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/h water no. days a thiamethoxam CGA 224 L (L/ha) interval Italy, 99 (Friarello) sweet peppers WG.. 2 d 8/9 Italy, 99 (Peto) sweet peppers Spain, 996 (Estrella) sweet peppers Spain, 996 (r.6) sweet peppers Spain, 99 (Italico) sweet peppers Spain, 99 (Sonora) sweet peppers Spain, 999 (Italico) sweet peppers, greenhouse Spain, 999 (Italico) sweet peppers, greenhouse Spain, 999 (Italico) sweet peppers, greenhouse Spain, 999 (Italico) sweet peppers, greenhouse Spain, 22 (Gallego) sweet peppers, protected WG.. 2 d WG d WG d WG d WG d WG WG WG WG d 2 d 2 d 2 d WG. drip b 5 2 d fruits fruits fruits.6.6. fruits..9.8 fruits fruits fruits fruits fruits fruits fruits <.2 (2) (2) (2).2 82/9 /96 2/96 9/9 /9 2/99 trial 2/99 trial 2 /99 trial /99 trial plot

100 886 Thiamethoxam PEPPERS Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/h water no. days a thiamethoxam CGA 224 L (L/ha) interval Spain, 22 (Gallego) sweet peppers, protected WG.2 drip 5 2 fruits plot 2 Switzerland, 996 (Lamiyo) sweet peppers, greenhouse Switzerland, 996 (Poivrons vert) sweet peppers, greenhouse Switzerland, 99 (Bendico) sweet peppers, greenhouse Switzerland, 99 (Lamiyo) sweet peppers, greenhouse Switzerland, 99 (Spirits) sweet peppers, greenhouse UK, 99 (Bell Boy) sweet peppers, greenhouse WG d WG d WG d WG d WG d WG. 5 2 d fruits fruits fruits fruits fruits fruits a PHI. - Sample taken just before the final application. b drip: drip application, adapting the knapsack sprayer to the irrigation system. <.2 6/96 5/96 6/9 8/9 /9 OV-98 Table 5 Thiamethoxam residues in egg plant resulting from supervised trials in Switzerland and the UK EGG PLAT Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hl water no. days a thiamethoxam CGA 224 (L/ha) interval Switzerland, 99 (Baluroi F) WG d 5/9 Switzerland, 99 (Galine) Switzerland, 99 (Marfa) WG d WG d fruit fruit fruit /9 /9

101 Thiamethoxam 88 EGG PLAT Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hl water no. days a thiamethoxam CGA 224 (L/ha) interval UK, 99 (Vista) greenhouse WG. 5 2 d OV-986 a PHI. Sample taken just before the final application. - fruit Pesticide residue trials on okra were conducted in Côte d'ivoire in 24 (Doumbia M and Yoboue Kouassi, 25, CI/AIPR/24/). Combinations of pesticides, including thiamethoxam, were tested at two different sites and in the different seasons. The analytical method used for thiamethoxam residue analysis was an imidacloprid residue analytical method, presumably adapted to thiamethoxam (Morris, 25, PRES/64). o validation data were available, but procedural recoveries of 8% and % were recorded (Whetton, no date, 6/22). Metabolite CGA 224 residues were not included in the analyses and the reported residues of thiamethoxam include only thiamethoxam (Table 54). Table 54 Thiamethoxam residues in okra resulting from supervised trials in Côte d'ivoire OKRA Application PHI Commodity Residue, mg/kg a Ref Country, Form kg ai/ha days thiamethoxamcga 224 Côte d'ivoire, WS seed treatment, CI/AIPR/24/ 24 (Indiana) Abengourou dry season.5 g ai/kg seed a Côte d'ivoire, 24 (Indiana) Abengourou rainy season WS seed treatment,.5 g ai/kg seed a CI/AIPR/24/ Côte d'ivoire, 24 (Indiana) Dabou dry season Côte d'ivoire, 24 (Indiana) Abengourou dry season Côte d'ivoire, 24 (Indiana) Dabou dry season WS seed treatment,.5 g ai/kg seed a WG. WG. 2 apps, 2 days interval 2 apps, 2 days interval 2 b 2 CI/AIPR/24/ CI/AIPR/24/ CI/AIPR/24/ Côte d'ivoire, WG. apps, days 2 b. CI/AIPR/24/ 24 (Indiana) Abengourou rainy season interval Côte d'ivoire, WG. apps, days 2. CI/AIPR/24/ 24 (Indiana) Dabou rainy season interval Côte d'ivoire, WG. app 2 CI/AIPR/24/ 24 (Indiana) Abengourou dry season Côte d'ivoire, WG. app 2 CI/AIPR/24/ 24 (Indiana) Dabou dry season Côte d'ivoire, 24 (Indiana) Dabou rainy season WG. app CI/AIPR/24/ a CI/AIPR/24/. Described as a seed treatment on page 4-5 of report, Described as soil treatment before

102 888 Thiamethoxam b CI/AIPR/24/. Sampling was scheduled for 2 days after treatment, but took place days after treatment (page 2 of report). The residue data table (page 69 of report) records residues 2 days after treatment. Thiamethoxam may be used as a soil treatment at sowing or in foliar applications during the production of lettuce, celery and spinach. Several use patterns were examined in the supervised trials in the USA on lettuce, celery and spinach (Campbell, 998, ABR-985): Two foliar sprays of WG (water dispersible granules) formulation at.99 kg ai/ha with a days interval and a and days PHI. Application as an in-furrow spray of SL (soluble concentrate) formulation at. kg ai/ha at planting, followed by a foliar spray of WG formulation at.49 kg ai/ha with a and days PHI. Application as a narrow surface band of SL formulation at. kg ai/ha during planting and incorporation to a depth of approx 4 mm with irrigation over 24 hours. Follow with a foliar spray of WG formulation at.49 kg ai/ha with a and days PHI. Application as a transplant drench of SL formulation at. kg ai/ha, followed by a foliar spray of WG formulation at.49 kg ai/ha with a and days PHI. Several use patterns were also examined in the supervised trials in the USA on lettuce (Campbell and Pyles, 2, 95-99): Application as an in-furrow spray of SL (soluble concentrate) formulation at.2 kg ai/ha at planting. Application as an in-furrow spray of SL formulation at.99 kg ai/ha at planting, followed by a 'shanked-in' soil application of SL formulation to the root zone at.99 kg ai/ha approximately days PHI. Application as a transplant drench of SL formulation at.2 kg ai/ha at planting. Application as transplant drench of SL formulation at.99 kg ai/ha, followed by a 'shanked-in' soil application to the root zone of SL formulation at.99 kg ai/ha approximately days PHI. Application as a 'shanked-in' soil application of SL formulation to the root zone at.2 kg ai/ha approximately days PHI. Two foliar sprays of WG (water dispersible granules) formulation at.99 kg ai/ha with a days interval and a days PHI. Table 55 Thiamethoxam residues in lettuce resulting from supervised trials in the USA. Replicate values arise from replicate field samples LETTUCE Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam b CGA 224 b a (L/ha) interval USA (CA), 2 (Aregan Red) leaf lettuce SL d leaves TR- 8- USA (FL), 999 (Black Seeded Simpson) leaf lettuce USA (FL), 999 (Black Seeded Simpson) leaf lettuce SL.2 if 94 6 leaf IR-9-99 SL.99 if +.99 si d leaf IR-9-99

103 Thiamethoxam 889 LETTUCE Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam b CGA 224 b a (L/ha) interval USA (CA), 2 (Great Lakes) head lettuce SL d 6 Head + wrapper USA (FL), 999 (Black Seeded Simpson) leaf lettuce USA (CA), 999 (Green Genie) leaf lettuce USA (CA), 999 (Green Genie) leaf lettuce USA (CA), 999 (Green Genie) leaf lettuce USA (CA), 999 (Green Genie) leaf lettuce USA (AZ), 99 (Crisp and Green), leaf lettuce 6 Head W-TR- 9-6 Wrapper leaf SL.2 si leaf IR-9-99 SL.2 dr 4 68 leaf W-IR SL USA (CA), 998 SL (Great Lakes), head WG lettuce USA (CA), 998 SL (Waldmanns green), WG leaf lettuce USA (CA), 998 (Waldmanns green), leaf lettuce USA (FL), 99 SL (Black Seeded), leaf WG lettuce USA (FL), 99 SL (Black Seeded), leaf WG lettuce USA (FL), 99 (Michigan Peto), head lettuce.99 dr +.99 si d 5 leaf W-IR SL.2 si 2 5 leaf W-IR control plot SL. sb 6 ote 6 SL WG. if +.5. if +.5. if +.5. sb +.5. dr control plot leaf leaf head head + wrapper leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf head head + wrapper head head + wrapper c.4. c.5.4 c..8 c.. c.9. c c. c c 2. c. c. c leaf W-IR ABR- 985 W-IR ABR IR-49-9 ABR IR-5-9 ABR IR-5-9 ABR IR-- 9 ABR IR-- 9 ABR IR W-IR The planned foliar application was omitted. 2-IR-5-9. Field plots were reported as flooded by rainfall after the soil drench application, which apparently contaminated the control plot.

104 89 Thiamethoxam LETTUCE Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam b CGA 224 b a (L/ha) interval USA (CA), 99 SL. sb (Great Lakes), head WG lettuce USA (CA), 99 (Pipus), head lettuce USA (AZ), 99 (Raider), head lettuce USA (CA), 99 (Prize Head), leaf lettuce SL WG SL WG SL WG USA (CA), 99 SL (Green Vision), leaf WG lettuce USA (Y), 99 (Black Seeded Simpson), leaf lettuce USA (Y), 99 (Black Seeded Simpson), leaf lettuce USA (Y), 99 (Crispino), head lettuce USA (Y), 99 (Crispino), head lettuce USA (CA), 2 (Aregan Red) leaf lettuce USA (CA), 2 (Great Lakes) head lettuce SL WG SL WG SL WG SL WG. if +.5. sb +.5. sb +.5. if +.5. if +.5. sb +.5. if +.5. sb WG d WG d head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf head head + wrapper head head + wrapper head head + wrapper head head + wrapper c c leaves Head + wrapper head + wrapper c c ABR- 985 W-IR ABR- 985 W-IR ABR- 985 W-IR ABR- 985 W-IR- 5-9 ABR- 985 W-IR ABR- 985 E-IR ABR- 985 E-IR ABR- 985 E-IR- 8-9 ABR- 985 E-IR TR W-TR- 9-6 head head.2.. USA (FL), 999 (Black Seeded Simpson) leaf lettuce WG d 6 wrapper leaf..9 wrapper leaf leaf IR-9-99

105 Thiamethoxam 89 USA (CA), 998 (Great Lakes), head lettuce WG. 2 2 d USA (CA), 998 WG. 2 2 (Waldmanns green), d leaf lettuce USA (FL), 99 WG. 4 2 (Black Seeded), leaf d lettuce USA (FL), 99 (Michigan Peto), head lettuce WG d USA (CA), 99 WG. 2 (Great Lakes), head d lettuce USA (CA), 99 (Pipus), head lettuce USA (AZ), 99 (Raider), head lettuce USA (CA), 99 (Prize Head), leaf lettuce WG d WG d WG. 2 d USA (CA), 99 WG (Green Vision), leaf 8d lettuce USA (AZ), 99 (Crisp and Green), leaf lettuce WG. 2 d head head + wrapper head + wrapper head + wrapper head + wrapper head + wrapper leaf leaf leaf leaf leaf leaf leaf leaf head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper head head + wrapper leaf leaf leaf leaf leaf leaf LETTUCE Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam b CGA 224 b a (L/ha) interval USA (CA), 999 (Green Genie) leaf lettuce WG.99 2 d leaf W-IR ABR IR-49-9 ABR IR-5-9 ABR IR-- 9 ABR IR-2-9 ABR- 985 W-IR ABR- 985 W-IR ABR- 985 W-IR ABR- 985 W-IR- 5-9 ABR- 985 W-IR ABR- 985 W-IR- 59-9

106 892 Thiamethoxam USA (Y), 99 (Crispino), head lettuce WG. 2 2 d head head + wrapper head head + wrapper LETTUCE Application PHI Commodity Residue, mg/kg c Ref country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam b CGA 224 b a (L/ha) interval USA (Y), 99 (Black Seeded Simpson), leaf lettuce WG. 2 2 d leaf leaf leaf c c ABR- 985 E-IR ABR- 985 E-IR- 8-9 a if: in-furrow treatment at planting. - sb: soil surface band treatment at planting, - si: shanked in treatment along the root zone. b c: sample from control plot c In study ABR-985, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 56 Thiamethoxam residues in spinach resulting from supervised trials in the USA. Replicate values arise from replicate field samples SPIACH Application PHI CommodityResidue, mg/kg c Ref Country, Form kg ai/ha a kg ai/hlwater (L/ha) no. interval days thiamethoxam b CGA 224 b USA (TX), 2 (Cascade) SL d leaf leaf S-TR-2- USA (CA), 2 (St Helens) SL d leaf leaf W-TR-92- USA (CA), 998 SL. if 94 leaf ABR-985 (St Helens) WG leaf IR-5-9 USA (TX), 996 SL. if leaf ABR-985 (Cascade) WG leaf S-IR--9 USA (TX), 996 SL. sb leaf ABR-985 (Cascade) WG leaf S-IR--9 USA (CA), 99 SL. sb 2 leaf ABR-985 (St Helens) WG leaf W-IR-5-9 USA (CO), 99 SL. if 99 leaf.6, ABR-985 (Melody) WG leaf MW-IR-2-9 USA (CO), 99 SL. sb 25 leaf ABR-985 (Melody) WG leaf MW-IR-2-9 USA (VA), 99 SL. if 94 leaf ABR-985 (Bloomsdate Long) WG leaf... E-IR-2-9 USA (VA), 99 (Bloomsdate Long) USA (J), 99 (TYEE F) USA (J), 99 (TYEE F) USA (TX), 2 (Cascade) USA (CA), 2 (St Helens) USA (CA), 998 (St Helens) USA (CA), 998 (St Helens) USA (TX), 996 (Cascade) SL WG. sb SL. if 5 WG SL. sb 5 WG WG d WG d WG. 2 2 d control plot WG. 2 2 d leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf c c c. c ABR-985 E-IR-2-9 ABR-985 E-IR-52-9 ABR-985 E-IR S-TR W-TR-92- ABR IR-5-9 ABR IR-5-9 ABR-985 S-IR--9

107 Thiamethoxam 89 SPIACH Application PHI CommodityResidue, mg/kg c Ref Country, Form kg ai/ha a kg ai/hlwater (L/ha) no. interval days thiamethoxam b CGA 224 b USA (CA), 99 (St Helens) WG d USA (CO), 99 (Melody) WG. 2 2 d USA (VA), 99 WG. 2 2 (Bloomsdate d Long) USA (J), 99 WG (TYEE F) + 6d leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf leaf a if: in-furrow treatment at sowing. sb: soil surface band treatment at sowing, incorporated b c: sample from control plot c In study ABR-985, the reported individual residue results had been adjusted for procedural recovery ABR-985 W-IR-5-9 ABR-985 MW-IR-2-9 ABR-985 E-IR-2-9 ABR-985 E-IR-52-9 Table 5 Thiamethoxam residues in beans (succulent) resulting from supervised trials in the USA BEAS Application PHI Commodity b Residue, mg/kg Ref country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (Y), 2 FS.5 seed 5 snap beans 589.-Y (Flo) snap beans treatment USA (Y), 2 FS.4 seed 5 snap beans 589.-Y (Flo) snap beans treatment USA (MD), 2 (Provider) snap beans FS.5 seed treatment 5 snap beans MD USA (MD), 2 (Provider) snap beans USA (GA), 2 (Strike) snap beans USA (GA), 2 (Strike) snap beans USA (FL), 2 (SB 4) snap beans USA (FL), 2 (SB 4) snap beans USA (ID), 2 (Burpee Stringless, Landreth) snap beans FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment USA (ID), 2 (Burpee Stringless, Landreth) snap beans FS.4 seed treatment USA (WI), 2 FS.5 seed (Hystyle, Green treatment Podded Bush Bean) snap beans USA (WI), 2 FS.4 seed (Hystyle, Green treatment Podded Bush Bean) snap beans 5 snap beans MD 6 snap beans 589.-GA 6 snap beans 589.-GA 5 snap beans 589.-FL6 5 snap beans 589.-FL6 snap beans 589.-ID9 snap beans 589.-ID9 58 snap beans 589.-WI 58 snap beans 589.-WI

108 894 Thiamethoxam BEAS Application PHI Commodity b Residue, mg/kg Ref country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (WI), 2 (BBL56) snap beans FS.5 seed treatment 6 snap beans 589.-WI2 USA (WI), 2 (BBL56) snap beans USA (J), 2 (Fordhook 242) lima beans USA (J), 2 (Fordhook 242) lima beans USA (MD), 2 (Fordhook 242) lima beans USA (MD), 2 (Fordhook 242) lima beans USA (GA), 2 (Cangreen) lima beans USA (GA), 2 (Cangreen) lima beans USA (ID), 2 (Henderson) lima beans USA (ID), 2 (Henderson) lima beans USA (CA), 2 (Fordhook 242) lima beans USA (CA), 2 (Fordhook 242) lima beans USA (WI), 2 (Fordhook 242) lima beans USA (WI), 2 (Fordhook 242) lima beans FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment a Interval from sowing to harvest. Seed was treated days to months before sowing. 6 snap beans 589.-WI2 lima beans 589.-J2 lima beans 589.-J2 8 lima beans MD8 8 lima beans MD8 8 lima beans 589.-GA2 8 lima beans 589.-GA2 2 lima beans 589.-ID 2 lima beans 589.-ID 2 lima beans 589.-CA59 2 lima beans 589.-CA59 9 lima beans 589.-WI2 9 lima beans 589.-WI2 b Lima bean samples include only the succulent seed; pods are discarded. - Snap bean samples include succulent seeds and pods. Table 58 Thiamethoxam residues in peas (succulent) resulting from supervised trials in the USA PEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg Days a b thiamethoxam CGA 224 seed USA (J), 2 FS.5 seed treatment 5 succulent shelled 66.-J8 (Improved Laxton's Progress) peas USA (J), 2 (Improved Laxton's Progress) FS.4 seed treatment 5 succulent shelled peas. 66.-J8

109 Thiamethoxam 895 PEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg Days a b thiamethoxam CGA 224 seed USA (WI), 2 FS.5 seed treatment succulent shelled 66.-WI5 (Dual) peas USA (WI), 2 FS.4 seed treatment succulent shelled 66.-WI5 (Dual) peas USA (I), 2 FS.5 seed treatment 55 succulent shelled 66.-I2 (Knight) peas USA (I), 2 FS.4 seed treatment 55 succulent shelled 66.-I2 (Knight) peas USA (OH), FS.5 seed treatment 5 succulent shelled 66.-OH 2 (Bolero) peas USA (OH), FS.4 seed treatment 5 succulent shelled 66.-OH 2 (Bolero) peas USA (WA), 2 (Oregon Trail) FS.5 seed treatment succulent shelled peas 66.-WA USA (WA), 2 (Oregon Trail) USA (CA), 2 (Cascadia) USA (CA), 2 (Cascadia) USA (I), 2 (Knight) USA (I), 2 (Knight) USA (OR), 2 (Oregon Sugar Pod II) USA (OR), 2 (Oregon Sugar Pod II) USA (CA), 2 (Oregon Sugar Pod II) USA (CA), 2 (Oregon Sugar Pod II) USA (CA), 2 (Oregon Sugar Pod II) USA (CA), 2 (Oregon Sugar Pod II) FS.4 seed treatment succulent shelled peas FS.5 seed treatment succulent shelled peas FS.4 seed treatment succulent shelled peas FS.5 seed treatment 5 succulent shelled peas FS.4 seed treatment 5 succulent shelled peas FS.5 seed treatment 65 peas, succulent edible pods FS.4 seed treatment 65 peas, succulent edible pods FS.5 seed treatment 65 peas, succulent edible pods FS.4 seed treatment 65 peas, succulent edible pods FS.5 seed treatment 65 peas, succulent edible pods FS.4 seed treatment 65 peas, succulent edible pods a Interval between sowing and sampling. b Succulent shelled pea samples include only the succulent seed; pods are discarded. Samples of 'peas, succulent edible pods' include succulent seeds and pods. 66.-WA 66.-CA2 66.-CA2 66.-I4 66.-I4 66.-OR8 66.-OR8 66.-CA 66.-CA 66.-CA CA Table 59 Thiamethoxam residues in beans (dry) resulting from supervised trials in the USA BEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg days a thiamethoxam CGA 224 seed USA (Y), 2 FS.5 seed 9 dry beans 65.-Y (California Light Red Kidney) treatment USA (Y), 2 (California Light Red Kidney) FS.4 seed treatment 9 dry beans 65.-Y

110 896 Thiamethoxam BEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg days a thiamethoxam CGA 224 seed USA (D), 2 FS.5 seed 5 dry beans 65.-D (Maverick) treatment USA (D), 2 FS.4 seed 5 dry beans 65.-D (Maverick) treatment USA (D), 2 FS.5 seed 5 dry beans 65.-D8 (Maverick) treatment USA (D), 2 FS.4 seed 5 dry beans 65.-D8 (Maverick) treatment USA (WA), 2 FS.5 seed 92 dry beans 65.-WA2 (Othello) treatment USA (WA), 2 FS.4 seed 92 dry beans 65.-WA2 (Othello) treatment USA (CO), 2 FS.5 seed 9 dry beans 65.-CO4 (Winchester) treatment USA (CO), 2 FS.4 seed 9 dry beans 65.-CO4 (Winchester) treatment USA (CO), 2 FS.5 seed 2 dry beans 65.-CO5 (Winchester) treatment USA (CO), 2 FS.4 seed 2 dry beans 65.-CO5 (Winchester) treatment USA (CA), 2 FS.5 seed 2 dry beans 65.-CA99 (Bush Blue Lake 24) treatment USA (CA), 2 (Bush Blue Lake 24) USA (WI), 2 (Red Kidney ROG82) USA (WI), 2 (Red Kidney ROG82) USA (WI), 2 (Red Kidney ROG82) USA (WI), 2 (Red Kidney ROG82) FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment FS.5 seed treatment FS.4 seed treatment a Interval between sowing and sampling. 2 dry beans 65.-CA99 86 dry beans 65.-WI5 86 dry beans 65.-WI5 86 dry beans 65.-WI6 86 dry beans 65.-WI6 Thiamethoxam may be used as a seed treatment on peas. In some trials the treated seed were analysed for thiamethoxam content for comparison with the nominal value. It was explained that the average seed loading achieved in industry was approximately %. Trials with seed loading exceeding % of nominal would not be considered as deviating from the protocol (Smith, 998, gr 49). Table 6 Thiamethoxam residues in peas resulting from supervised trials with seed treatment in Europe PEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg seed days a thiamethoxam CGA 224 Denmark, 996 WS.525 (nominal) 2 green pods <.5 <.5 IR996 c (4-92, part 96-8).442 (by analysis) green pods green seed dry seed <.5 <.5 (2) <.5 <.5 (2) Denmark, 996 (4-92, part 96-8) WS.525 (nominal).442 (by analysis) whole green pods empty green pods green seed dry seed <.5 <.5 <.5 <.5 <.5 <.5 OV-988 c

111 Thiamethoxam 89 PEAS Application PHI Commodity Residue, mg/kg Ref country, Form g ai/kg seed days a thiamethoxam CGA 224 France, 996 WS mature grains OS964/KJ95 (Rustic) France, 996 WS.52 8 mature grains.2 OS964/SJ5 (Tonus) Germany, 99 WS gr 49 (Baccara) Germany, 99 (Baccara) Germany, 99 (Baccara) Germany, 99 (Baccara) France, 99 (Baccara) France, 998 (Rustic) France, 998 (Baccara) France, 996 (Solara) France, 996 (Tonus) France, 996 (Solara) France, 996 (Solara) France, 99 (Solara) France, 99 (Baccara) France, 99 (Solara) France, 99 (Baccara) France, 998 (Baccara) WS FS FS.525 (nominal).44 (by analysis) (. kg ai/ha).525 (nominal).44 (by analysis) (. kg ai/ha).525 (nominal).469 (by analysis) (. kg ai/ha).525 (nominal).469 (by analysis) (. kg ai/ha) pods with seed pea seed empty pods dry peas pods with seed pea seed empty pods dry peas pods with seed pea seed empty pods dry peas pods with seed pea seed empty pods dry peas <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 gr 529 gr 69 gr 29 WS.5 9 dry seeds, harvest 945 FS dry seeds, harvest b 984 FS.52 dry seeds, harvest (2) (2) 9849 WS.5 6 grain at maturity OS964/AC2 WS.49 8 grain at maturity OS964/AC2 WS.52 grain at maturity OS964/FP WS.52 grain at maturity OS964/LD99 WS.5 22 seeds at harvest 945 WS.5 seeds at harvest 9454 WS.5 2 seeds at harvest 9455 WS.5 9 seeds at harvest 9456 FS seeds at harvest a Interval between sowing and sampling. b Study 984. Some recoveries were in the 4 % range, but were adequate to assure that residues did not exceed the LOQs reported. c The same treated seed was used and the seeds were sown on the same day, but the field locations were different in these Danish trials. Table 6 Thiamethoxam residues in peas (dry) resulting from supervised trials in the USA PEAS Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (D), 2 FS.5 seed treatment 84 dry peas 59.-D9 (Majoret) USA (D), 2 FS.4 seed treatment 84 dry peas 59.-D9 (Majoret)

112 898 Thiamethoxam PEAS Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (D), 2 FS.5 seed treatment 84 dry peas 59.-D (Majoret) USA (D), 2 FS.4 seed treatment 84 dry peas 59.-D (Majoret) USA (WA), 2 FS.5 seed treatment 8 dry peas 59.-WA (Columbian) USA (WA), 2 FS.4 seed treatment 8 dry peas WA (Columbian) USA (WA), 2 FS.5 seed treatment dry peas 59.-WA (Columbian) USA (WA), 2 FS.4 seed treatment dry peas WA (Columbian) USA (ID), 2 FS.5 seed treatment dry peas 59.-ID6 (Early Alaska) USA (ID), 2 (Early Alaska) FS.4 seed treatment dry peas 59.-ID6 a Interval from sowing to harvest. Table 62 Thiamethoxam residues in soya beans resulting from supervised trials in the USA SOYA BEAS Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg days a thiamethoxam CGA 224 seed USA (OH), 22 FS.5 seed treatment soya bean dry 26-2 (K S4 B2) seed K-SR--2 USA (SD), 22 FS.5 seed treatment 2 soya bean dry 26-2 (AG 62) seed C-SR-2-2 USA (C), 22 FS.5 seed treatment 92 soya bean dry 26-2 (DP688RR) seed SJ-SR-2-2 USA (AR), 22 (Delta King 566RR) USA (VA), 22 (Hutcheson) USA (D), 22 (Mycogen 5) USA (M), 22 (AgriPro 2RR) USA (IA), 22 (K S24-K4) USA (I), 22 (S-V8) USA (MS), 22 (HBK 489) USA (MO), 22 (K X9R) USA (IL), 22 (H-55RR) USA (B), 22 (Excel 8RR) USA (KS), 22 (S9Q4) USA (MI), 22 (92BI) FS.5 seed treatment 4 soya bean dry seed 26-2 SE-SR--2 FS.5 seed treatment 2 soya bean dry 26-2 seed EB-SR-2-2 FS.5 seed treatment 8 soya bean dry 26-2 seed WI-SR-2-2 FS.5 seed treatment 26 soya bean dry 26-2 seed F-SR--2 FS.5 seed treatment 8 soya bean dry 26-2 seed E-SR--2 FS.5 seed treatment 2 soya bean dry 26-2 seed J-SR--2 FS.5 seed treatment soya bean dry 26-2 seed S-SR--2 FS.5 seed treatment 5 soya bean dry 26-2 seed D-SR-2-2 FS.5 seed treatment soya bean dry 26-2 seed 4-SR--2 FS.5 seed treatment soya bean dry 26-2 seed B-SR-2-2 FS.5 seed treatment 6 soya bean dry 26-2 seed A-SR-2-2 FS.5 seed treatment 8 soya bean dry 26-2 seed ED-SR--2 a Interval from sowing to harvest.

113 Thiamethoxam 899 Thiamethoxam may be used as a soil treatment at sowing or in foliar applications during the production of carrots. Three use patterns were examined in the supervised trials on carrots in the USA (Barney, 24, 468): Application to the soil (narrow band or below seed level) of SL (soluble concentrate) formulation at.22 kg ai/ha at sowing. The soil application was followed by approximately 2 mm irrigation within 24 to 48 hours. Two foliar sprays of WG (water dispersible granules) formulation at. kg ai/ha with a days interval and a days PHI. Two foliar sprays of SL formulation at. kg ai/ha with a days interval and a days PHI. Table 6 Thiamethoxam residues in carrots resulting from supervised trials in the USA. Replicate values arise from replicate field samples CARROT Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 a (L/ha) interval USA (CA), 2 SL carrot root (Minicor 'Baby band CA Var') USA (CA), 2 SL carrot root (antes) band CA6 USA (CA), 2 SL. 2 carrot root (antes) d CA6 USA (CA), 2 SL carrot root (Caro Pak) band CA5 USA (FL), 2 SL.22 (Chantenay Red band Core) USA (FL), 2 SL. 2 (Chantenay Red Core) d USA (OH), SL.22 2 (Apache) band USA (TX), 2 SL.2 (antes band Coreless) USA (WA), SL.2 2 (Bolero) band USA (CA), 2 WG.4 (Minicor 'Baby +.69 Var') USA (CA), 2 (antes) USA (CA), 2 WG. (Caro Pak) +.4 USA (FL), 2 (Chantenay Red Core) WG. 2 d d WG. 2 d USA (OH), 2 (Apache) WG. 4 2 d USA (TX), 2 WG (antes 6d Coreless) USA (WA), 2 (Bolero) WG.2 2 d carrot root FL8 carrot root FL carrot root OH carrot root TX2 8 carrot root WA carrot root d CA carrot root CA6 carrot root CA5 carrot root FL8 carrot root OH8 carrot root TX2 8 carrot root WA4 a band: narrow soil-applied spray band at or below seed level at sowing. This soil application was followed by approx 2 mm irrigation within 24 to 48 hours.

114 9 Thiamethoxam Thiamethoxam may be used as a soil treatment at sowing or in foliar applications during the production of radishes. Three use patterns were examined in the supervised trials in the USA on radishes (Barney, 24, 6). Application to the soil (narrow band or below seed level) of SL (soluble concentrate) formulation at. or.22 kg ai/ha at sowing. The soil application was followed by approximately 2 mm irrigation within 24 to 48 hours. One foliar spray of WG (water dispersible granules) formulation at. kg ai/ha with a days PHI. One foliar spray of SL formulation at. kg ai/ha with a days PHI. Table 64 Thiamethoxam residues in radish resulting from supervised trials in the USA. Replicate values arise from replicate field samples RADISH Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 a (L/ha) interval USA (CA), 2 SL radish tops (Cherry Belle) band 4 4 radish tops radish roots CA USA (CA), 2 (Cherry Belle) USA (FL), 2 (Cherry Belle) USA (FL), 2 (Cherry Belle) USA (FL), 2 (Cabernet) USA (MD), 2 (Champion) SL. 5 SL band SL. 2 d SL band 2 SL. band USA (Y), 2 SL. (Vintage) band USA (OH), 2 SL. (SRA 5) band USA (OH), 2 SL. 46 (SRA 5) USA (CA), 2 WG. 5 (Cherry Belle) USA (FL), 2 WG. 2 (Cherry Belle) d USA (FL), 2 WG (Cabernet) 6 USA (MD), 2 WG. 2 (Champion) USA (Y), 2 (Vintage) WG radish tops radish tops radish roots radish tops radish roots radish tops radish roots radish tops radish roots radish tops radish tops radish roots radish tops radish roots radish tops radish roots radish tops radish roots radish tops radish tops radish roots radish tops radish roots radish tops radish roots radish tops radish tops radish roots radish tops radish roots <.(2) <.(2) <. (2) <. (2) <. (2) CA 6.- FL2 6.- FL2 6.- FL 6.- MD6 6.- Y OH2 6.- OH2 6.- CA 6.- FL2 6.- FL 6.- MD6 6.- Y22 a band: narrow soil-applied spray band at or below seed level at sowing. This soil application was followed by approx 2 mm irrigation within 2 to 24 hours.

115 Thiamethoxam 9 Table 65 Thiamethoxam residues in potato tubers resulting from supervised trials in France, Germany, Spain, Switzerland and the UK POTATO Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hl water no., days thiamethoxam CGA 224 (L/ha) interval France, 99 WG tubers (2) (2) /9 (Concurrente) ,, d (2) (2) France, 99 WG tubers (2) (2) 2/9 (Monalisa) d (2) (2) France, 99 (Monalisa) WG d 952 France, 99 (Monalisa) France, 99 (O'Sirena) Germany, 99 (Agria) Germany, 99 (Elcana) Spain, 99 (Kenebec) Spain, 99 (Monalisa) Spain, 99 (Spunta) Spain, 999 (Red Pontiac) Switzerland, 996 (Agria) Switzerland, 996 (Eba) Switzerland, 99 (Agria) Switzerland, 99 (Bintje) UK, 996 (Estima) UK, 996 (Saturna) UK, 99 (Maris Piper) WG d WG d WG d WG d WG d WG d WG d WG d WG d WG d WG d WG d WG tubers tubers tubers tubers <.2 tubers tubers (2) (2) tubers (2) (2) (2) (2) (2) (2) gr 649 gr 6229 /9 2/9 tubers (2) (2) (2) (2) 26/9 tubers 25/99 (2) (2) tubers (2) (2) 6/96 tubers (2) (2) /96 tubers (2) (2) tubers (2) (2) (2) (2) (2) (2) /9 26/9 tubers IR96 d WG tubers IR96 9 d WG tubers () () OV-98 d () () Thiamethoxam may be used as a seed-piece treatment or in foliar applications during the production of potatoes. Several use patterns were examined in the supervised trials on potatoes in the USA (Boyette, 2, 59-98):

116 92 Thiamethoxam Seed-piece treatment with FS (flowable concentrate for seed treatment) formulation at sowing at 8 g ai per kg seed-pieces, equivalent to.2 kg ai/ha. Seed-piece treatment with FS formulation at sowing at 24 g ai per kg seed-pieces, equivalent to.6 kg ai/ha. Seed-piece treatment with FS formulation at sowing at 6 g ai per kg seed-pieces, equivalent to.5 kg ai/ha and foliar spray with WG (water-dispersible granules) formulation at.4 kg ai/ha and days PHI. Two foliar sprays with WG formulation at.99 kg ai/ha each, days interval and days PHI. Two foliar sprays with WG formulation at.49 kg ai/ha each, days interval and days PHI. Seed-piece treatment with DS (powder for dry seed treatment) formulation at sowing at 8 g ai per kg seed-pieces, equivalent to.2 kg ai/ha. Table 66 Thiamethoxam residues in potato tubers resulting from supervised trials in the USA. Replicate values arise from replicate field samples POTATO Application PHI Commodity Residue, mg/kg c Ref Country, Form kg ai/ha a water no., days Thiamethoxam b CGA 224 b (L/ha) interval USA (CA), 998 (Cal White) FS.2 spt8 9 mature tuber SR-5-98 USA (CA), 998 (Cal White) USA (FL), 998 (La Rouge) USA (FL), 998 (La Rouge) USA (FL), 998 (La Rouge) USA (FL), 998 (La Rouge) DS.2 spt8 9 mature tuber SR-5-98 WG d FS.2 spt DS.2 spt FS.5 spt6 + WG USA (ID), WG (Ranger d Russet) USA (ID), 998 (Ranger Russet) WG.49 2 d tuber tuber tuber tuber mature tuber mature tuber tuber tuber tuber tuber mature tuber mature tuber tuber tuber tuber tuber mature tuber mature tuber tuber tuber tuber tuber mature tuber mature tuber FL-SR FL-SR FL-SR FL-SR-5-98 mature tuber W-SR-6-98 mature tuber W-SR , FL-SR Potato sample, 8 days after treatment had a residue of. mg mg/kg of CGA 224, but on analysis of a second aliquot from the same extract, no residue was detected.

117 Thiamethoxam 9 POTATO Application PHI Commodity Residue, mg/kg c Ref Country, Form kg ai/ha a water no., days Thiamethoxam b CGA 224 b (L/ha) interval USA (ID), 998 (Ranger FS.2 spt8 mature tuber W-SR-6-98 Russet) USA (ID), 998 (Ranger Russet) FS.6 spt24 mature tuber W-SR-6-98 USA (ID), WG (Ranger d Russet) mature tuber W-SR-4-98 USA (ID), FS.2 spt8 mature tuber (Ranger W-SR-4-98 Russet) USA (ID), 998 (Ranger Russet) USA (ID), 998 (Ranger Russet) USA (OR), 998 (Russet Burbank) USA (D), 998 (Red Pontiacs) USA (D), 998 (Red Pontiacs) USA (M), 998 (Red Pontiacs) USA (M), 998 (Red Pontiacs) USA (WA), 998 (Russet Burbank) USA (WA), 998 (Russet Burbank) USA (WA), 998 (Russet Burbank) USA (WA), 998 (Russet Burbank) USA (FL), 998 (Atlantic) USA (FL), 998 (Atlantic) USA (C), 998 (Kennebec) WG.99 2 d FS.2 spt WG.99 2 d tuber tuber tuber tuber mature tuber mature tuber tuber tuber tuber tuber mature tuber mature tuber W-SR W-SR mature tuber W-SR--98 FS.2spt8 98 mature tuber W-SR FS.6spt24 98 mature tuber W-SR WG d mature tuber W-SR-2-98 FS.2 spt8 8 mature tuber W-SR-2-98 WG d mature tuber W-SR FS.2 spt8 2 mature tuber W-SR WG d mature tuber W-SR FS.2 spt8 2 mature tuber W-SR WG d mature tuber SR-4-98 FS.2 spt8 mature tuber SR-4-98 WG d mature tuber S-SR-66-98

118 94 Thiamethoxam POTATO Application PHI Commodity Residue, mg/kg c Ref Country, Form kg ai/ha a water no., days Thiamethoxam b CGA 224 b (L/ha) interval USA (C), 998 (Kennebec) FS.2 spt8 mature tuber S-SR USA (ME), 998 (FL 625) USA (ME), 998 (FL 625) USA (MI), 998 (Yukon Golds) USA (MI), 998 (Yukon Golds) USA (WI), 998 (ewleaf Russet Burbank) USA (WI), 998 (ewleaf Russet Burbank) USA (Y), 998 (Katahdin) USA (Y), 998 (Katahdin) USA (CO), 998 (orkata) USA (CO), 998 (orkata) USA (CA), 998 (Red Lasota) USA (CA), 998 (Red Lasota) WG d mature tuber E-SR-8-98 FS.2 spt8 mature tuber E-SR-8-98 WG d mature tuber E-SR-2-98 FS.2 spt8 mature tuber E-SR-2-98 WG d mature tuber MW-SR--98 FS.2 spt8 24 mature tuber MW-SR--98 WG.99 2 d 2 mature tuber SR-5-98 FS.2 spt8 9 mature tuber SR-5-98 WG d mature tuber c c.2 c c c c MW-SR-6-98 FS.2 spt8 4 mature tuber MW-SR-6-98 WG d mature tuber W-SR FS.2 spt8 22 mature tuber W-SR a spt8: seed-piece treatment at sowing at 8 g ai/ kg seed-pieces, equivalent to.2 kg ai/ha. spt24: seed-piece treatment at sowing at 24 g ai/ kg seed-pieces, equivalent to.6 kg ai/ha. spt6: seed-piece treatment at sowing at 6 g ai/ kg seed-pieces, equivalent to.5 kg ai/ha. b c: sample from control plot c In study 59-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Thiamethoxam may be used as a seed treatment during the production of sugar beet. In the supervised trials in Europe, the application rate was provided as g ai/unit, where the unit is, 9 Potato trial 59-98, MW-SR-6-98 in the USA (CO). Analyses were repeated twice. Residues of thiamethoxam were detected in a sample from the control plot in one of these analyses suggesting possible contamination.

119 Thiamethoxam 95 seeds. When the sowing rate, number of seeds per hectare, is known, the application rate as kg ai/ha may be calculated (Smith, 998, gr 829). Example: for thiamethoxam on sugar beet, the target seed treatment rate was 6 g ai per, seeds, equivalent to. kg ai/ha for a sowing rate of 6, seeds per hectare. Table 6 Thiamethoxam residues in sugar beet resulting from supervised trials in France, Germany, Italy, etherlands, Spain, Sweden, Switzerland and the UK SUGAR BEET Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha days thiamethoxam CGA 224 seed treatment France, 996 (Gabriella) WS.8 (8 g ai per, seeds, 2, seed per hectare) roots (2) (2) OS964 AC France, 996 (Gabriella) France, 996 (Gabriella) France, 99 (Anik) France, 99 (Elisa) France, 99 (Elisa) Germany, 99 (Patricia) Germany, 99 (Patricia) Germany, 998 (Patricia) Italy, 996 (Gabriela) Italy, 996 (Gabriela) Italy, 99 (Gabriela) Italy, 99 (Gabriela, KWS seed) etherlands, 998 (icola) Spain, 996 (Gabriela) WS. (8. g ai per, seeds, 5, seeds per hectare) WS.8 (8. g ai per, seeds,, seeds per hectare) WS.5 (46 g ai per, seeds,, seed per hectare) WS.8 (59.8 g ai per, seeds,, seeds per hectare) WS.note 4 (6 g ai per, seeds, 4.25 kg seed per hectare) WS. (6 g ai per, seeds, 6, seeds per hectare) WS.6 (6 g ai per, seeds,, seeds per hectare) WS.2 (6 g ai per, seeds, 2, seeds per hectare) WS. (9 g ai per, seeds, 8, seeds per hectare) WS. (9 g ai per, seeds, 85, seeds per hectare) WS.2 (64 g ai per, seeds, 85, seeds per hectare) WS. (64 g ai per, seeds, 8, seeds per hectare) WS.6 (6 g ai per, seeds,, seeds per hectare) WS.9 (9 g ai per, seeds,, seeds per hectare) 82 roots OS964/DE2 8 roots OS964/KJ9 6 roots roots roots (2) (2) beet beet beet beet beet beet gr 829 gr 949 gr roots (2) (2) 85/96 6 roots (2) (2) 86/96 58 roots (2) (2) 9/9 54 roots (2) (2) 92/9 roots (2) (2) 6/98 56 roots (2) (2) 5/96 4 Sugar beet Assume g per seeds. (Smith, 998, gr 892).

120 96 Thiamethoxam SUGAR BEET Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha days thiamethoxam CGA 224 seed treatment Spain, 99 (Gabriela) WS.5 (64 g ai per, seeds, 8, seeds per hectare) 85 roots (2) (2) 8/9 Sweden, 998 (Patricia) Switzerland, 995 (KWS) UK, 998 (icola) WS.2 (6 g ai per, seeds, 2, seeds per hectare) WS.9 (9 g ai per, seeds, seeds per hectare) WS (6 g ai per, seeds, sowing rate not reported) 95 beet beet gr roots (2) 5/95 9 roots (2) (2) 6/98 Table 68 Thiamethoxam residues in artichokes resulting from supervised trials in the USA. Replicate values arise from replicate field samples ARTICHOKE Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no., days thiamethoxam CGA 224 (L/ha) interval USA (CA), 22 (Green Globe) WG.5 2 d 4 artichoke CA8 USA (CA), 22 (Green Globe) USA (CA), 22 (Green Globe) WG.5 2 d WG.5 2 6d 4 artichoke CA9 4 artichoke CA4 Table 69 Thiamethoxam residues in celery resulting from supervised trials in the USA. Replicate values arise from replicate field samples CELERY Application PHI Commodity Residue, mg/kg b Ref country, Formkg ai/ha a kg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval USA (CA), 99 SL. dr leaf stalk.2.25 ABR-985 (Conquistador) WG leaf stalk.5.6 W-IR-5-9 USA (CA), 99 (Conquistador) USA (CA), 99 (Conquistador) USA (CA), 99 (525) USA (FL), 99 (June Bell 622) USA (MI), 99 (Florida 68k) USA (CA), 99 (Conquistador) SL WG SL WG SL WG SL WG SL WG. dr +.5. dr +.5. dr +.5. dr +.5. dr WG. 2 8d 5 9 leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk ABR-985 W-IR-5-9 ABR-985 W-IR-52-9 ABR-985 W-IR-5-9 ABR-985 FL-IR-4-9 ABR-985 E-IR-- 9 ABR-985 W-IR-5-9

121 Thiamethoxam 9 CELERY Application PHI Commodity Residue, mg/kg b Ref country, Formkg ai/ha a kg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval USA (CA), 99 WG. 2 leaf stalk.6.8 ABR-985 (Conquistador) 8d leaf stalk..25 W-IR-5-9 USA (CA), 99 (Conquistador) USA (CA), 99 (525) USA (FL), 99 (June Bell 622) USA (MI), 99 (Florida 68k) WG d WG d WG. 2 d WG. 2 d leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk leaf stalk ABR-985 W-IR-52-9 ABR-985 W-IR-5-9 ABR-985 FL-IR-4-9 ABR-985 E-IR-- 9 a dr: drench treatment at sowing. b In study ABR-985, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses Table Thiamethoxam residues in maize resulting from supervised trials with seed treatment uses in France, Germany and Spain MAIZE Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg seed days a thiamethoxam CGA 224 France, 996 WS. 69 grain OS9646/KJ92 (Antarès) France, 996 WS grain OS9646/SJ9 (Bemol) France, 996 WS.2 59 grain OS9646/LD95 (Dunia) France, 996 WS. grain.4 OS9646/AC8 (Furio) France, 99 WS. grain 9462 (Antarès) France, 99 WS. 5 grain 946 (Bahia) France, 99 WS.2 59 grain 94 (Furio) France, 99 WS.2 grain 942 (Occitan) France, 998 FS.4 52 grain (2) (2) 984 (Bahia) France, 998 FS.2 2 grain (2) (2) 9845 (Furio) France, 998 FS.2 5 grain (2) (2) 9842 (Occitan) France, 999 FS.4 58 grain (2) (2) 9942 (Anjou 5) France, 999 FS.4 89 grain 994 (Anjou 5) France, 999 (Occitan) FS.4 FS includes fludioxonil and metalaxyl-m 2 grain (2) (2) France, 999 (Occitan) FS.4 FS includes fludioxonil and metalaxyl-m grain 9942

122 98 Thiamethoxam MAIZE Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg seed days a thiamethoxam CGA 224 Germany, 996 WS.5 grain gr 6296 (Bahia) (.8 kg ai/ha) Germany, 99 WS.5 grain gr 89 (Antarès) (. kg ai/ha) Germany, 99 WS.5 5 grain gr 829 (Antarès) (. kg ai/ha) Germany, 99 WS.5 55 grain gr 8249 (Antarès) (.99 kg ai/ha) Germany, 99 FS.5 grain gr 89 (Antarès) (. kg ai/ha) Germany, 99 FS.5 5 grain gr 8429 (Antarès) (. kg ai/ha) Spain, 996 WS.2 maize grain (2) (2) /96 (Dracma) Spain, 996 WS.2 6 maize grain (2) (2) 2/96 (Dracma) Spain, 99 (Juanita) WS.5 (nominal) 2.4 (analysis) 6 grain (2) (2) 9/9 a Interval between sowing and sampling. Table Thiamethoxam residues in maize resulting from supervised trials with seed treatment uses in the USA. Replicate values arise from replicate field samples MAIZE Application PHI Commodity Residue, mg/kg c Ref Country, Form g ai/kg seed Days a thiamethoxam CGA 224 USA (CA), 998 (Pioneer FS seed treatment 5 grain SR ) USA (IL), 998 FS 4.5 seed 55 grain (Pioneer 568) treatment 4-SR-6-98 USA (IL), 998 FS 4.5 seed 55 grain (Pioneer 568) treatment 4-SR-6-98 USA (Y), 998 (Pioneer 568) FS.5 seed treatment USA (TX), 998 FS 4.5 seed (Pioneer 94) treatment USA (C), FS 4.5 seed 998 (Pioneer treatment 94) USA (IA), 998 FS 4.5 seed (Pioneer 94) treatment USA (IA), 998 FS 4.5 seed (Pioneer 94) treatment USA (IA), 998 FS.5 seed (Pioneer 94) treatment USA (MO), 998 (Pioneer 94) FS 4.5 seed treatment USA (KS), 998 FS 4.5 seed (Pioneer 94) treatment USA (IL), 998 FS 4.5 seed (Pioneer 22) treatment USA (IA), 998 FS 4.5 seed (Pioneer 5) treatment 6 grain SR--98 grain S-SR-2-98 grain S-SR-6-98 grain MW-SR grain MW-SR-5-98 grain MW-SR grain MW-SR grain MW-SR grain MW-SR grain MW-SR FS: flowable concentrate for seed treatment. Analysis for active ingredient content: 49 and 4 g g/kg.

123 Thiamethoxam 99 MAIZE Application PHI Commodity Residue, mg/kg c Ref Country, Form g ai/kg seed Days a thiamethoxam CGA 224 USA (SD), 998 FS 4.5 seed 59 grain (Pioneer 5) treatment MW-SR USA (E), 998 FS 4.5 seed grain (Pioneer 5) treatment MW-SR USA (E), 998 FS 4.5 seed 2 grain (Pioneer 5) treatment MW-SR USA (WI), 998 FS 4.5 seed 5 grain (Pioneer 5) treatment MW-SR--98 USA (M), 998 (Pioneer 82) FS 4.5 seed treatment 6 grain MW-SR-8-98 USA (M), 998 (Pioneer 82) USA (I), 998 (Pioneer 568) USA (I), 998 (Pioneer 94) USA (OH), 998 (Pioneer 94) USA (MI), 998 (Pioneer 568) FS 4.5 seed treatment FS 4.5 seed treatment FS 4.5 seed treatment FS 4.5 seed treatment FS 4.5 seed treatment 58 grain MW-SR grain E-SR grain E-SR grain E-SR grain E-SR-8-98 a Interval between sowing and sampling. b In study 58-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 2 Thiamethoxam residues in barley resulting from supervised trials in the USA. Replicate values arise from replicate field samples BARLEY Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval USA (ID), 2 (Steptoe) WG d 2 barley grain ID8 USA (ID), 2 (Colter) WG.69 2 d 2 barley grain 46.- ID9 USA (ID), 22 (Eight Twelve) WG d 2 barley grain ID USA (ID), 22 (Eight Twelve) WG d 2 barley grain ID USA (D), 22 WG barley grain (Drummound) 6 d D6 USA (D), 22 WG barley grain (Robust) 6 d D USA (SD), 22 (Robust) WG. 8 2 d 2 barley grain SD4 USA (SD), 22 (Lacey) WG. 8 2 d 2 barley grain SD5 USA (WA), 22 WG barley grain (Columbia) + d WA22

124 9 Thiamethoxam Table Thiamethoxam residues in barley resulting from supervised seed treatment trials in France, Germany and the UK BARLEY Application PHI Commodity Residue, mg/kg Ref Country, Form g ai per kg seed days a thiamethoxam CGA 224 seed treatment France, 996 WS barley grain OS94/LD2 (Intro) sowing rate: kg seed/ha France, 996 WS barley grain OS94/KJ (Labea) sowing rate: 6 kg seed/ha France, 996 WS.6 2 barley grain OS9642/SJ6 (evada) sowing rate: 25 kg seed/ha France, 996 WS.62 barley grain OS94/AC9 (Plaisant) sowing rate: 8 kg seed/ha France, 996 WS.6 22 barley grain OS9642/AC (Prisma) sowing rate: kg seed/ha France, 996 WS.6 26 barley grain OS9642/LD98 (Prisma) sowing rate: 2 kg seed/ha France, 99 (evada) spring barley France, 99 (Prisma) spring barley France, 998 (Esterel) winter barley France, 998 (Gaelic) winter barley France, 998 (Maeva) winter barley France, 998 (evada) spring barley France, 998 (evada) spring barley France, 998 (Pastoral) winter barley France, 998 (Plaisant) winter barley France, 998 (Prisma) spring barley France, 998 (Prisma) spring barley France, 999 (Cork) spring barley WS.6 sowing rate: 24 kg seed/ha 25 barley grain 94 WS.65 barley grain 942 sowing rate: 85 kg seed/ha FS.6 sowing rate: 5 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol 262 barley grain.2 < FS.4 sowing rate: kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol 242 barley grain FS.6 22 barley grain sowing rate: 85 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS. 5 barley grain 984 sowing rate: kg seed/ha FS includes fludioxonil, CGA 294, flutriafol FS. 24 barley grain sowing rate: 5 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS barley grain 9946 sowing rate: 2 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.6 26 barley grain 9946 sowing rate: 8 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.8 56 barley grain 9848 sowing rate: 8 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS. 25 barley grain 9842 sowing rate: 25 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.4 25 barley grain (2) (2) sowing rate: kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol

125 Thiamethoxam 9 BARLEY Application PHI Commodity Residue, mg/kg Ref Country, Form g ai per kg seed seed treatment days a thiamethoxam CGA 224 France, 999 (Scarlett) spring barley Germany, 996 (Krona) Germany, 99 (Baronesse) spring barley FS.6 sowing rate: 2 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol WS.6 sowing rate: 5 kg seed/ha WS.62 sowing rate: kg seed/ha barley grain (2) (2) barley grain gr barley grain gr 6949 UK, 996 WS.5 8 barley grain IR296 (Optic) spring barley sowing rate: 2 kg seed/ha UK, 996 WS.56 barley grain IR96 (Optic) spring barley sowing rate: 2 kg seed/ha UK, 99 (Fighter) winter barley WS.5 22 barley grain (2) (2) OV-9825 a Interval between sowing and sampling. Table 4 Thiamethoxam residues in wheat resulting from supervised trials in France, Germany, Switzerland and the UK WHEAT Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval France, 996 WG.5. 4 wheat grain OI964/AC2 (Eureka) 2 wheat grain France, 996 WG.5. 4 grains OI964/KJ6 (Soissons) 2 grains France, 996 WG.5. 4 wheat grain (2) (2) OI96 (Soissons) soft wheat France, 99 (Ami) soft wheat WG.5.5 wheat grain 92 France, 99 (Eureka) soft wheat France, 99 (Filou) spring wheat France, 99 (Furio) spring wheat France, 99 WG WS WG WS WG st b.5. 4 st b wheat grain wheat grain wheat grain wheat grain wheat grain wheat grain WG.5. 4 wheat grain 9 (Hugo) soft wheat France, 99 WS st b wheat grain (Prinqual) spring wheat WG wheat grain France, 99 (Prinqual) spring wheat France, 99 (Soisson) soft wheat France, 99 (Soissons) soft wheat WS WG st b WG wheat grain wheat grain wheat grain wheat grain WG.5. 4 wheat grain 9

126 92 Thiamethoxam WHEAT Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 (L/ha) interval France, 99 WG.5. 4 grains 98 (Texel) 2 grains France, 99 WG.6. 4 wheat grain 982 (Victo) soft wheat 2 wheat grain Germany, 99 (Devon) spring wheat WS WG st a wheat grain wheat grain gr 6449 Germany, 99 (Devon) spring wheat Germany, 99 (Devon) spring wheat Germany, 99 (Devon) spring wheat Switzerland, 996 (Albis) Switzerland, 99 (Runal) WS WG WS WG WS WG st a.5 4 st a.5 4 st a wheat grain gr wheat grain wheat grain gr 659 wheat grain 42. gr 659 WG wheat grain (2) (2) /96 WG.5 5 wheat grain. (2) /96 UK, 99 (Riband) WG wheat grain.2.2 () OV-9822 winter wheat UK, 99 (Riband) WG wheat grain...4 () OV-982 winter wheat UK, 99 (Riband) WG wheat grain.2 (2) () OV-9824 winter wheat a st: seed treatment at.6 g ai/kg seed. b st: seed treatment at.6 g ai/kg seed. Table 5 Thiamethoxam residues in wheat resulting from supervised seed treatment trials in France, Germany and the UK WHEAT Application PHI Commodity Residue, mg/kg b Ref Country, Form g ai per kg seed Days a thiamethoxam CGA 224 seed treatment France, 996 (Filou) WS.59 sowing rate: 25 kg seed/ha 25 wheat grain OS964/AC6 France, 996 (Furio) France, 996 (Soissons) France, 996 (Trémie) France, 99 (Florence Aurore) WS.59 sowing rate: 25 kg seed/ha WS.59 sowing rate: 2 kg seed/ha WS.58 sowing rate: 6 kg seed/ha WS.6 sowing rate: 5 kg seed/ha 9 wheat grain OS964/SJ 22 wheat grain OS942/AC98 2 wheat grain OS942/KJ2 wheat grain Wheat grain and bran, gr 659. Reported values have been adjusted for procedural recoveries, adjustment factor =.68 for thiamethoxam.

127 Thiamethoxam 9 WHEAT Application PHI Commodity Residue, mg/kg b Ref Country, Form g ai per kg seed Days a thiamethoxam CGA 224 seed treatment France, 99 (Florence Aurore) spring wheat FS.59 sowing rate: 8.5 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 56 wheat grain France, 99 (Florence Aurore) spring wheat France, 99 (Prinqual) spring wheat France, 99 (Prinqual) spring wheat France, 99 (Scipion) winter wheat France, 99 (Sidéral) WS.6 sowing rate: 22 kg seed/ha WS.6 sowing rate: 8 kg seed/ha WS.6 sowing rate: 25 kg seed/ha FS.6 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin WS.6 sowing rate: 6 kg seed/ha France, 99 FS.59 (Sidéral) winter wheat sowing rate: 8.5 kg seed/ha also contains fludioxonil, difenoconazole France, 99 FS.6 (Sidéral) winter sowing rate: 8.5 kg wheat seed/ha also contains fludioxonil, difenoconazole, tefluthrin France, 99 (Soissons) winter wheat France, 99 (Vivant) winter wheat France, 99 (Vivant) winter wheat FS.6 sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.58 sowing rate: 6 kg seed/ha also contains fludioxonil, difenoconazole FS.59 sowing rate: 6 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 6 wheat grain 942 wheat grain 94 wheat grain wheat grain wheat grain OS942/LD 25 wheat grain wheat grain wheat grain wheat grain wheat grain 9844

128 9 Thiamethoxam WHEAT Application PHI Commodity Residue, mg/kg b Ref Country, Form g ai per kg seed Days a thiamethoxam CGA 224 seed treatment France, 998 (Florence Aurore) spring wheat FS.5 sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole wheat grain 9846 France, 998 (Florence Aurore) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Orqual) France, 998 (Orqual) France, 998 (Prinqual) spring wheat FS.5 sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.58 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.56 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole FS.58 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.56 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole FS.6 sowing rate: 25 kg seed/ha also contains fludioxonil, difenoconazole FS.6 sowing rate: 25 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.56 sowing rate: 6 kg seed/ha also contains fludioxonil, difenoconazole wheat grain wheat grain wheat grain wheat grain wheat grain wheat grain (2) (2) wheat grain (2) (2) wheat grain 98462

129 Thiamethoxam 95 WHEAT Application PHI Commodity Residue, mg/kg b Ref Country, Form g ai per kg seed Days a thiamethoxam CGA 224 seed treatment France, 998 (Ritmo) FS.62 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 262 wheat grain (2) (2) 994 France, 998 (Ritmo) soft winter wheat France, 998 (Sideral) France, 998 (Sideral) France, 998 (Sideral) soft winter wheat France, 998 (Vivant) FS.62 sowing rate: 8 kg seed/ha also contains fludioxonil FS.6 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole FS.6 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.6 sowing rate: kg seed/ha also contains fludioxonil FS.6 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 262 wheat grain (2) (2) wheat grain (2) (2) wheat grain (2) (2) wheat grain (2) (2) wheat grain (2) (2) 9942 Germany, 996 WS.6 2 wheat grain gr 696 (Hanno) spring wheat sowing rate 85 kg seed/ha Germany, 99 WS.64 6 wheat grain gr 689 (Hanno) spring wheat sowing rate 8 kg seed/ha UK, 996 (Hunter) winter wheat WS wheat grain () () OV-982 a Interval between sowing and sampling. b c: sample from control plot. Thiamethoxam may be used as a granular treatment of the seed box and as a foliar spray during the production of rice. In rice trials in Japan (Table 6), residue data were provided in reverse decline trials, i.e. plots were sprayed at selected time intervals and the grain and straw samples were all harvested on the same day.

130 96 Thiamethoxam Table 6 Thiamethoxam residues in rice resulting from supervised trials in Brazil and Japan RICE Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha d kg ai/hlwater no. days thiamethoxam CGA 224 c (L/ha) a Japan, GR hulled grain Jun-29 (Yumemizuho) SC b Japan, (Hinchikari) Brazil (PR), 2 (Guarani) Brazil (PR), 2 (Guarani) GR SC FS WG FS WG Brazil (MG), 2 FS (Carajás) WG Brazil (MG), 2 FS (Carajás) WG Brazil (SP), 2 (IAC-22) Brazil (SP), 2 (IAC-22) Brazil (GO), 2 (Aimoré) Brazil (GO), 2 (Aimoré) Brazil (SP), 24 (Amarelão) Brazil (SP), 24 (Amarelão) FS WG FS WG FS WG FS WG FS WG FS WG Brazil (MG), 2 FS (Aymoré) WG Brazil (MG), 2 FS (Aymoré) WG a st st. 2.4 st st. 2.4 st st..4 st. e st.56 e 25.4 st. e st.56 e 25.4 st. e st.56 e b d d d d d d + 5 d d d d d d 2 hulled grain rice... rice.6. rice rice.6 rice.5 rice..4.5 rice (duplicate plots) rice (duplicate plots) rice (duplicate plots) rice (duplicate plots) rice (duplicate plots) rice (duplicate plots) < Jun-29 M49 trial M49- RPK M49 trial M49- RPK M49 trial M49- JJB M49 trial M49- JJB M49 trial M49- LZF M49 trial M49- LZF M25 trial HJF M25 trial HJF M25 trial LZF M25 trial LZF M25 trial JJB M25 trial JJB

131 Thiamethoxam 9 a Seed box treatment with granules (thiamethoxam 8 g/kg, also contains pyroquilon) at 5 g product per box. b Reverse decline trial. Plots were sprayed on separate occasions with sampling all on the same day. c o study numbers or report numbers appeared on the documents of the trials in Japan, so they are identified by date. d st: seed treatment, expressed as g ai/kg seed. e Lambda-cyhalothrin included in the foliar application. In five of the pecan trials in the USA, applications with a low-volume concentrated spray simulated aerial application. The spray volumes for the low-volume applications were 9 9 L/ha, while spray volumes for high volume were 9 4 L/ha. Table Thiamethoxam residues in pecans resulting from supervised trials in the USA. Replicate values arise from replicate field samples PECA Application PHI Commodity Residue, mg/kg Ref country, Form kg kg water no. days thiamethoxam CGA 224 ai/ha ai/hl (L/ha) interval USA (GA), 998 WG a.4 2 (Desirable) d USA (AL), 998 WG a (Cape Fear) d USA (M), 998 WG a (Western Schley) d USA (M), 998 WG a.4 2 (Western Schley) d USA (LA), 998 WG a (Jackson) d USA (LA), 998 WG a (Jackson) d USA (TX), 998 WG a (Pawnee) d USA (TX), 998 (Pawnee) WG a.4 2 d a WG also contains pymetrozine. 8 pecan kernel 4-98 S-IR pecan kernel 4-98 S-IR pecan kernel 4-98 S-IR pecan kernel 4-98 S-IR-2-98 pecan kernel 4-98 S-IR-9-98 pecan kernel 4-98 S-IR-9-98 pecan kernel 4-98 S-IR pecan kernel 4-98 S-IR Thiamethoxam may be used as a seed treatment on sunflower seeds. Two seed-treatment formulations were examined in the supervised trials on sunflower in the USA (Campbell and Pyles, 2, -99). Treated seed were analysed to determine the actual treatment rate: FS (flowable concentrate for seed treatment) formulation used in a seed-treatment slurry at 4 g ai per kg seeds. WS (water dispersible powder for slurry seed treatment) formulation used in a seedtreatment slurry at 4 or 2 g ai per kg seeds.

132 98 Thiamethoxam Table 8 Thiamethoxam residues in sunflower seed resulting from supervised trials in the USA. Replicate values arise from replicate field samples. SUFLOWER Application PHI Commodity Residue, mg/kg Ref Country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (D), 999 FS.8 seed (SF2) treatment USA (D), 999 WS.4 seed (SF2) treatment USA (D), 999 WS.8 seed (SF2) treatment USA (D), 999 WS 2.2 seed (SF2) treatment USA (SD), 999 (SF2) USA (SD), 999 (SF2) USA (SD), 999 (SF2) USA (SD), 999 (SF2) FS.5 seed treatment WS. seed treatment WS 4. seed treatment WS. seed treatment USA (E), 999 WS 4.6 seed (SF2) treatment USA (KS), 999 (SF2) WS. seed treatment a Interval between sowing and sampling seed, premature seed, premature seed, mature seed, post mature seed, premature seed, premature seed, mature seed, post mature -99 W-SR W-SR seed, mature -99 W-SR seed, mature -99 W-SR seed, premature seed, premature seed, mature seed, post mature seed, premature seed, premature seed, mature seed, post mature -99 W-SR W-SR seed, mature -99 MW-SR seed, mature -99 MW-SR seed, mature -99 MW-SR seed, mature -99 MW-SR-- 99 Thiamethoxam may be used as a seed treatment and in foliar applications during the production of cotton. Three use patterns were examined in the supervised trials in the USA on cotton (Campbell, 998, 4-9): FS formulation used in a seed-treatment slurry at g ai per kg seed, followed by WG formulation as two foliar sprays at.5 kg ai/ha, minimum 4 L/ha, days interval and 2 days PHI. FS formulation used in a seed-treatment slurry at g ai per kg seed, followed by WG formulation as two foliar sprays at.5 kg ai/ha, minimum 4 L/ha, days interval and 2 days PHI. FS formulation used in a seed-treatment slurry at g ai per kg seed, followed by WG formulation as two foliar sprays at.25 kg ai/ha, minimum 4 L/ha, days interval and 2 days PHI. Thiamethoxam may be used as a seed treatment and in foliar applications during the production of cotton. Three use patterns were examined in the supervised and processing trials in the USA on cotton (Eudy et al., 999, 2-98).

133 Thiamethoxam 99 8 FS formulation used in a seed-treatment slurry at g ai per kg seed, followed by WG formulation as two foliar sprays at.2 kg ai/ha, minimum 4 L/ha, 5 days interval. 9 WG formulation as two foliar sprays at.45 kg ai/ha, minimum 4 L/ha, 5 days interval WG formulation as two foliar sprays at.225 kg ai/ha, minimum 4 L/ha, 5 days interval, in combination with emamectin as an EC. Table 9 Thiamethoxam residues in cotton seed resulting from supervised trials in the USA. Replicate values arise from replicate field samples COTTO Application PHI Commodity Residue, mg/kg b, c Ref Country, year (variety) Form kg ai/ha a water (L/ha) no. interval days thiamethoxam CGA 224 USA (AL) FS 99 (DPL- + WG 5) USA (AR) FS 99 + WG (D&PL 5) USA (AZ) FS 99 (DPL- + WG 5) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) FS 99 (Acala + WG Maxxa) USA (CA) 99 (Maxxa) USA (LA) 99 (DP- 5) FS + WG FS + WG USA (MS) FS 99 (DPL + WG 5) USA (M) 99 (HS- 2) FS + WG USA (OK) FS 99 + WG (Paymaster ) USA (TX) FS 99 (DPL + WG 5) USA (TX) FS 99 (DPL- + WG 5) g ai/kg seed.5 g ai/kg seed.5 84 g ai/kg seed.5 9 g ai/kg seed.5 9 g ai/kg seed.5 9 g ai/kg seed.25 9 g ai/kg seed.5 9 g ai/kg seed.5 9 g ai/kg seed.25 9 g ai/kg seed.5 g ai/kg seed.5 84 g ai/kg seed.5 g ai/kg seed.5 56 g ai/kg seed.5 5 g ai/kg seed.5 2 g ai/kg seed d + 2 d + 2 d + 2 d + 2 d + 2 d +2 d + 2 d + 2 d + 2 d + 2 d + 2 d + 2 d + 2 d + 2 6d + 2 d 2 cotton seed 4-9 S-R cotton seed S-R cotton seed 4-9 W-R cotton seed R cotton seed R cotton seed R cotton seed R cotton seed R cotton seed R cotton seed 4-9 W-R cotton seed 4-9 W-R cotton seed 4-9 -R-2-9 cotton seed S-R cotton seed 4-9 S-R cotton seed S-R cotton seed 4-9 S-R-8-9

134 92 Thiamethoxam COTTO Application PHI Commodity Residue, mg/kg b, c Ref Country, year (variety) Form kg ai/ha a water (L/ha) no. interval days thiamethoxam CGA 224 USA (TX) FS 99 (DPL- + WG 5) USA (TX) FS 99 (DPL- + WG 5) USA (TX) FS 99 (DPL- + WG 5) USA (TX) FS 99 (DPL- + WG 5) USA (TX) FS 99 (DPL- + WG 5) USA (TX) FS 99 (DPL + WG 5) USA (CA) FS 998 (Acala WG Maxxa) USA (CA) 998 (Acala Maxxa) USA (CA) 998 (Acala Maxxa) USA (MS) FS 998 (DP WG 5) USA (MS) 998 (DP 5) USA (AR) FS 998 (DPL WG 5) USA (AR) 998 (DPL 5) USA (TX) 998 (DP 5) USA (TX) 998 (DP 5) g ai/kg seed.5 84 g ai/kg seed g ai/kg seed.5 84 g ai/kg seed.5 84 g ai/kg seed g ai/kg seed.5 2 g ai/kg seed d + 2 d + 2 d +2 d + 2 d + 2 6d 2 (5d) 2 cotton seed 4-9 S-R cotton seed. 4-9 S-R cotton seed 4-9 S-R cotton seed 4-9 S-R cotton seed 4-9 S-R cotton seed cotton seed cotton seed cotton seed cotton seed S-R cotton seed IR-22-98/CA WG (5d) 2 cotton seed IR-22-98/CA WG (5d) 2 cotton seed IR-22-98/CA g ai/kg seed (5d) 2 cotton seed IR-- 98/MS WG (5d) 2 cotton seed IR-- 98/MS g ai/kg seed.2 2 (5d) 2 cotton seed 2-98 S-IR-2-98/AR WG.45 2 (5d) 2 cotton seed 2-98 S-IR-2-98/AR FS WG USA (TX) FS 998 (DPL WG 555) USA (TX) 998 (DPL 555) USA (TX) 998 (DPL 555) USA (TX) 998 (PM 226) g ai/kg seed (5d) 2 cotton seed S-IR-2-98/TX WG (5d) 2 cotton seed S-IR-2-98/TX g ai/kg seed (5d) 2 cotton seed 2-98 S-IR-6-98/TX WG (5d) 2 cotton seed 2-98 S-IR-6-98/TX WG (5d) 2 cotton seed 2-98 S-IR-6-98/TX FS WG g ai/kg seed (5d) 2 cotton seed cotton seed cotton seed cotton seed cotton seed S-IR-22-98/TX

135 Thiamethoxam 92 COTTO Application PHI Commodity Residue, mg/kg b, c Ref Country, year (variety) Form kg ai/ha a water (L/ha) no. interval days thiamethoxam CGA 224 USA (TX) 998 (PM 226) USA (OK) 998 (PM 8) USA (OK) 998 (PM 8) WG (5d) 2 FS WG USA (AL) FS 998 (DPL WG 5) USA (AL) 998 (DPL 5) USA (LA) FS 998 (DPL WG 5) USA (LA) 998 (DPL 5) USA (CA) 998 (MAXXA) USA (CA) 998 (MAXXA) g ai/kg seed.2 2 (5d) cotton seed cotton seed cotton seed cotton seed cotton seed S-IR-22-98/TX 24 cotton seed S-IR-24-98/OK WG.45 2 (5d) 24 cotton seed S-IR-24-98/OK g ai/kg seed (5d) 2 cotton seed S-IR-85-98/AL WG (5d) 2 cotton seed S-IR-85-98/AL g ai/kg seed (5d) 2 cotton seed 2-98 S-IR-92-98/LA WG (5d) 2 cotton seed S-IR-92-98/LA FS WG USA (AZ) FS 998 (Acala WG 9) USA (AZ) 998 (Acala 9) g ai/kg seed (5d) 2 WG (5d) 2 g ai/kg seed (5d) cotton seed cotton seed cotton seed cotton seed cotton seed cotton seed cotton seed cotton seed cotton seed cotton seed W-IR-- 98/CA 2-98 W-IR-- 98/CA 2 cotton seed 2-98 W-IR-58-98/AZ WG (5d) 2 cotton seed 2-98 W-IR-58-98/AZ a Study The nominal seed treatment rate, g ai/kg seed, is recorded in the table. Measured concentrations of thiamethoxam on the treated seed ranged from 2.26% to.4%, mean 2.66%, SD.22%, n=2. b In study 4-9, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. c In study 2-98, the reported residues had been adjusted for procedural recoveries. Table 8 Thiamethoxam residues in cotton seed resulting from supervised trials in Greece and Spain. Replicate values arise from replicate field samples COTTO Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha a kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval Greece, 996 WG.5.5 dehulled seed (2) (2) /96 (Express) 2, d cotton hulls <.5 (2) <.5 (2) Greece, 996 WG.5.5 dehulled seed (2) (2) 2/96 (Z2) 8, d cotton hulls <.5 (2) <.5 (2) Greece, 99 WS 2. ST dehulled seed (2) (2) 96/9 (Eva) WG d cotton hulls <.5 (2) <.5 (2)

136 922 Thiamethoxam COTTO Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha a kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval Greece, 99 WS 2.6 ST dehulled seed (2) (2) 9/9 (Eva) WG d cotton hulls <.5 (2) <.5 (2) Greece, 998 WG dehulled seed (2) (2) 66/98 (24 Stoneville) d cotton hulls <.5 (2) <.5 (2) Greece, 998 (Korina) WG d dehulled seed cotton hulls (2) <.5 (2) (2) <.5 (2) 65/98 Greece, 999 (ETH.I.AG.E- ) Greece, 999 (ETH.I.AG.E- ) Spain, 996 (Corona) Spain, 996 (Vulcano) Spain, 99 (Austral) Spain, 99 (Condor) Spain, 99 (Condor) WS WG WS WG.9 ST ST , d +, d WG.5. 5 d WG.5. 5 d WS 2.5 ST WG d WS WG WS WG 2.5 ST ST a ST: seed treatment, expressed as g ai per kg seed. + d + d dehulled seed cotton hulls dehulled seed cotton hulls (2) <.5 (2) (2) <.5 (2) dehulled seed cotton hulls <.5 dehulled seed cotton hulls <.5 dehulled seed cotton hulls <.5 2 dehulled seed 2 cotton hulls <.5 dehulled seed (2) cotton hulls <.5 (2) dehulled seed (2) cotton hulls <.5 (2) dehulled seed (2) cotton hulls <.5 (2) dehulled seed (2) cotton hulls <.5 (2) dehulled seed cotton hulls dehulled seed cotton hulls (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) <.5 <.5 <.5 <.5 (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) (2) <.5 (2) 4/99 5/99 9/96 2/96 5/9 /9 4/9 Table 8 Thiamethoxam residues in rape seed resulting from supervised trials in France, Germany, Sweden and the UK OILSEED RAPE country, France, 996 (Bristol) France, 996 (Bristol) France, 996 (Bristol) France, 996 (Goeland) France, 996 (Goeland) France, 996 (Goeland) France, 996 (Tanto) Application PHI Commodity Residue, mg/kg b Ref Form g ai per kg seed seed treatment Days a thiamethoxam CGA 224 WS rapeseed OS944/AC96 sowing rate: 9 kg seed/ha WS rapeseed OS944/KJ4 sowing rate: 2 kg seed/ha WS 4.5 rapeseed OS944/LD sowing rate:.5 kg seed/ha FS 4.4 rapeseed 8/9 sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m WS rapeseed OS944/AC95 sowing rate: 9 kg seed/ha WS 4. 6 rapeseed OS944/LD4 sowing rate:.5 kg seed/ha WS 5.4 rapeseed OS9645/AC4 sowing rate: 6 kg seed/ha

137 Thiamethoxam 92 OILSEED RAPE country, France, 996 (Tanto) France, 996 (Tanto) France, 996 (Tanto) France, 99 (Bristol) France, 99 (avajo) France, 99 (avajo) France, 99 (Tanto) France, 998 (Bristol) France, 998 (Capitol) France, 998 (Columbus) Germany, 996 (Evita) spring oil seed rape Germany, 996 (Evita) spring oil seed rape Germany, 99 (Evita) spring oil seed rape Germany, 99 (Evita) spring oil seed rape Germany, 998 (Evita) spring oilseed rape Germany, 998 (Laser) winter oilseed rape Germany, 998 (Laser) winter oilseed rape Germany, 998 (Licosmos) spring oilseed rape Application PHI Commodity Residue, mg/kg b Ref Form g ai per kg seed seed treatment Days a thiamethoxam CGA 224 WS rapeseed OS9645/AC5 sowing rate: 9 kg seed/ha WS rapeseed OS9645/FP2 sowing rate: 5 kg seed/ha WS 5.2 rapeseed OS9645/KJ94 sowing rate: 5 kg seed/ha FS rapeseed c.2 9/9 sowing rate: 4 kg seed/ha FS includes fludioxonil and metalaxyl-m FS 4.2 rapeseed 6/9 sowing rate:.5 kg seed/ha FS includes fludioxonil and metalaxyl-m FS rapeseed /9 sowing rate: 2.8 kg seed/ha FS includes fludioxonil and metalaxyl-m WS rapeseed 942 sowing rate: 8 kg seed/ha FS rapeseed (2) (2) /98 sowing rate: 6 kg seed/ha FS includes fludioxonil and metalaxyl-m FS rapeseed (2) (2) /98 sowing rate: 8 kg seed/ha FS includes fludioxonil and metalaxyl-m FS 4. 2 rapeseed (2) (2) 2/98 sowing rate: 2.5 kg seed/ha FS includes fludioxonil and metalaxyl-m WS 4. 2 rapeseed gr sowing rate: 5 kg seed/ha WS 4.8 sowing rate: kg seed/ha 5 rapeseed gr WS 5. 8 rapeseed gr 29 sowing rate:.5 kg seed/ha WS 5. 4 rapeseed gr 29 sowing rate: 4.5 kg seed/ha FS 4. sowing rate: 5. kg seed/ha FS includes fludioxonil and metalaxyl-m rapeseed gr 99 FS 4.2 sowing rate:.5 kg seed/ha FS includes fludioxonil and metalaxyl-m rapeseed gr 6299 FS rapeseed gr sowing rate:. kg seed/ha FS includes fludioxonil and metalaxyl-m FS rapeseed gr sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m

138 924 Thiamethoxam OILSEED Application PHI Commodity Residue, mg/kg b Ref RAPE country, Form g ai per kg seed Days a thiamethoxam CGA 224 seed treatment Germany, 998 FS 4.2 rapeseed gr (Licosmos) spring oilseed rape sowing rate: 6 kg seed/ha FS includes fludioxonil and metalaxyl-m Sweden, 998 FS 4. 5 rapeseed gr 6898 (Sponsor) spring oilseed rape sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m UK, 996 (Apex) winter oil seed rape WS 5. 2 rapeseed () () OV-989 UK, 996 (Sprinter) spring oil seed rape UK, 99 (Acrobat) spring oil seed rape UK, 99 (Apex) UK, 99 (Apex) WS 4. sowing rate: kg seed/ha 22 rapeseed IR96 WS 5. 6 rapeseed () () OV-982 FS.8 FS includes fludioxonil and metalaxyl-m FS.8 FS includes fludioxonil and metalaxyl-m a Interval between sowing and sampling. b c: sample from control plot 2 rapeseed () () 25/98 22 rapeseed () () 26/98 In the cocoa trials, the cacao beans were fermented and dried (Table 82). Fermentation: beans and pulp were removed from the pods, placed in black plastic containers which were hermetically closed. Every 48 hours the containers were opened and the beans stirred. The fermentation process took 5 days. Drying: fermented beans were placed in a thin layer on a black plastic sheet under the open sky in the day and were covered each night. They were stirred 2 times a day. The drying process took 5 days. Table 82 Thiamethoxam residues in cacao beans resulting from supervised trials at four different farms in Côte d'ivoire CACAO Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval Côte d'ivoire, WG fermented a,b / 2 (Selectioné IRCC) 42 d dried beans c Côte d'ivoire, 2 (Tout Venant) Côte d'ivoire, 2 (Selectioné IRCC) Côte d'ivoire, 2 (Tout Venant) WG d WG d WG d fermented dried beans fermented dried beans 29 fermented dried beans a,b c a,b c a,b c a Cultural practices. b care was taken to avoid cross-contamination while separating the beans from the pod and pulp. c traditional method, where no special precaution is taken to avoid cross-contamination. 29/ / /

139 Thiamethoxam 925 Thiamethoxam may be used as a soil drench during the production of coffee. Three use patterns with WG formulations were examined in the supervised trials in Brazil on coffee (Góis Marconi and Casallanovo, 29, M92): WG formulation containing thiamethoxam and cyproconazole used as a drench at. kg ai/ha of thiamethoxam, and 9 days later a WG formulation of thiamethoxam only applied as a second drench at.5 kg ai/ha. WG formulation containing thiamethoxam and cyproconazole used as a single drench at. kg ai/ha of thiamethoxam. WG formulation of thiamethoxam only applied as a single drench at.5 kg ai/ha. Three similar use patterns with the same application rates but based on GR application to the soil were also examined in supervised trials in Brazil on coffee (Góis Marconi and Casallanovo, 29, M92). Coffee cherries were collected, then dried and shelled to produce coffee beans. In four of the trials (M92), beans were also roasted. Table 8 Thiamethoxam residues in coffee beans resulting from supervised trials in Brazil COFFEE Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha method no. interval days thiamethoxam CGA 224 Brazil (MG), WG (Mundo WG ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai). a +.5 soil drench 2 9 d 6 9 WG. a soil drench WG.5 soil drench 6 9 WG WG. a +.5 control plot soil drench 2 9 d (6) (9) () 6 9 WG. a soil drench WG.5 soil drench 6 9 WG WG Brazil (MG), (Catuai) Brazil (MG), WG (Catuai) WG. a +.5 control plot soil drench 2 9 d (6) (9) () 6 9 WG. a soil drench 5 8 WG.5 soil drench 6 9. b +.5 control plot soil drench 2 9 d (6) (9) 6 9 coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans c. c. c c.2 c.2 c coffee beans coffee beans c. c.2 coffee beans.6 coffee beans.5 coffee beans c.2 c.2 c c.2 c.2 c c.2 c M92 trial JJB ote c M92 trial JJB ote c M92 trial JJB ote c M92 trial JJB M92 trial JJB2 ote d M92 trial JJB2 ote d M92 trial JJB2 ote d M92 trial JJB2 M92 trial JJB ote e M92 trial JJB ote e M92 trial JJB ote e M92 trial JJB M92 trial JJB4

140 926 Thiamethoxam COFFEE Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha method no. days thiamethoxam CGA 224 interval Brazil (MG), (Catuai) WG. a soil drench coffee beans coffee beans coffee beans M92 trial JJB4 Brazil (MG), (Catuai) Brazil (MG), WG (Mundo WG ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Mundo ovo) Brazil (SP), WG (Mundo WG ovo) Brazil (SP), (Mundo ovo) Brazil (SP), (Mundo ovo) Brazil (MG), GR (Mundo GR ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Catuai) Brazil (MG), (Catuai) Brazil (MG), (Catuai) WG.5 soil drench 6 9. a +.5 soil drench 2 9 d 6 9 WG. a soil drench 5 8 WG.5 soil drench 6 9. a +.5 soil drench 2 9 d 6 9 WG. a soil drench WG.5 soil drench 6 9. b +.5 soil treatment GR. b soil treatment GR.5 soil treatment GR GR. b +.5 soil treatment GR. b soil treatment GR.5 soil treatment Brazil (MG), (Catuai) control plot Brazil (MG), GR. b soil (Catuai) GR +.5 treatment Brazil (MG), GR. b soil (Catuai) treatment Brazil (MG), GR.5 soil (Catuai) treatment Brazil (MG), GR. b soil (Mundo GR +.5 treatment ovo) Brazil (MG), (Mundo ovo) Brazil (MG), (Mundo ovo) GR. b soil treatment GR.5 soil treatment 2 9 d d (6) (9) d d coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans coffee beans c. c. coffee beans.4 coffee beans.4 coffee beans. coffee beans.2 coffee beans.2 coffee beans.2 coffee beans.2 coffee beans.2 coffee beans coffee beans coffee beans coffee beans c.2 c M92 trial JJB4 M92 trial JJB5 M92 trial JJB5 M92 trial JJB5 M92 trial LZF M92 trial LZF M92 trial LZF M92 trial JJB M92 trial JJB M92 trial JJB M92 trial JJB2 ote f M92 trial JJB2 ote f M92 trial JJB2 ote f M92 trial JJB2 M92 trial JJB M92 trial JJB M92 trial JJB M92 trial JJB4 M92 trial JJB4 M92 trial JJB4 a The WG in the first application contains cyproconazole ( g/kg) and thiamethoxam ( g/kg). Thiamethoxam is the only active ingredient in the WG used in the second application.

141 Thiamethoxam 92 b The GR in the first application contains cyproconazole ( g/kg) and thiamethoxam ( g/kg). Thiamethoxam is the only active ingredient in the GR used in the second application. c M92 trial JJB. Trial results are suspect because of significant residues in samples from control plot. d M92 trial JJB2. Trial results are suspect because of significant residues in samples from control plot. e M92 trial JJB. Trial results are suspect because of significant residues in samples from control plot. f M92 trial JJB2. Trial results are suspect because of significant residues in samples from control plot. Table 84 Thiamethoxam residues in pea forage and fodder resulting from supervised trials with seed treatment in Denmark, France and Germany PEA FORAGE Application PHI Commodity Residue, mg/kg d Ref AD FODDER Country, Form g ai/kg seed Days a b thiamethoxam CGA 224 Denmark, 996 (4- WS.525 (nominal) whole plant.9.29 IR996 e 92, part 96-8).442 (by analysis) whole plant haulm haulm haulm <.5 <.5 <.5 <.5 (2) <.5 <.5 <.5 <.5 (2) Denmark, 996 (4-92, part 96-8) Germany, 99 (Baccara) Germany, 99 (Baccara) Germany, 99 (Baccara) Germany, 99 (Baccara) France, 99 (Baccara) France, 998 (Rustic) France, 998 (Baccara) France, 99 (Solara) France, 99 (Baccara) France, 99 (Solara) France, 99 (Baccara) France, 998 (Baccara) WS.525 (nominal).442 (by analysis) WS.525 (nominal).44 (by 8 analysis) (. kg ai/ha) WS.525 (nominal) (by 24 analysis) (. kg ai/ha) FS.525 (nominal).469 (by 8 analysis) (. kg ai/ha) FS.525 (nominal) (by 24 analysis) (. kg ai/ha) WS FS whole plant whole plant haulm haulm dry haulm whole plant haulm whole plant haulm whole plant haulm whole plant haulm whole plant haulm whole plant haulm.8. <.5 <.5 <.5 <.5 <.5.5 <.5 <.5 <.5. < <.5 <. c.8 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.4 <.4 <.5 <. OV-988 e gr 49 gr 529 gr 69 gr FS.52 haulm.. <. (2) 9849 WS whole plant haulm at harvest.4.2 <.4 < WS.5 5 whole plant.2 < haulm at harvest <.4 c.4.4 c.4 WS.5 6 whole plant.5 < haulm at harvest <.4.2 WS.5 69 whole plant. < haulm at harvest.8.9 FS haulm at harvest.2 < a Interval between sowing and sampling. b Haulm: whole plants with pods removed or straw with empty pods. c Study 984. Some recoveries were in the 4-% range, but were adequate to assure that residues did not exceed the LOQs reported. d c: sample from control plot.

142 9 Thiamethoxam e The same treated seed was used and the seeds were sown on the same day, but the field locations were different in these Danish trials. Table 85 Thiamethoxam residues in maize forage and fodder resulting from supervised trials with seed treatment uses on sweet corn and popcorn in the USA. Replicate values arise from replicate field samples MAIZE FORAGE & FODDER Country, USA (CA), 998 (Primetime) USA (IL), 998 (Kandy King) USA (Y), 998 (Kandy King) USA (FL), 998 (Golden Cross Bantam Hybrid) USA (C), 998 (Kandy King) USA (WA), 998 (Jubilee) Application PHI Commodity Residue, mg/kg a Ref Form g ai/kg seed FS 4.5 seed treatment FS 4.5 seed treatment 6 6 FS 4.5 seed treatment 62 9 FS 4.5 seed treatment FS 4.5 seed treatment FS 4.5 seed treatment 6 2 USA (WA), 998 (Jubilee) FS. seed treatment 6 2 USA (OR), FS 4.5 seed treatment (Primetime) USA (OR), 998 (Primetime) USA (WI), 998 (Jubilee) USA (M), 998 (Jubilee) USA (OH), 998 (Kandy King) FS. seed treatment FS 4.5 seed treatment FS 4.5 seed treatment FS 4.5 seed treatment USA (PA), 998 (Hybrid Sweet Fortune SD892-82) FS 4.5 seed treatment USA (MI), 999 (Kandy King) FS 4.5 seed treatment days thiamethoxam CGA 224 forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, incl ears forage, incl ears forage, incl ears forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears forage, incl ears forage, no ears stover forage, incl ears forage, no ears forage, incl ears forage, incl ears forage, incl ears forage, incl ears forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover forage, incl ears forage, no ears stover <.(2) SR SR SR SR S-SR W-SR W-SR W-SR W-SR MW-SR MW-SR E-SR E-SR E-SR--99

143 Thiamethoxam 929 MAIZE FORAGE & FODDER Country, USA (KS), 998 (M-22) popcorn USA (E), 998 (M-22) popcorn USA (I), 998 (M-22) popcorn Application PHI Commodity Residue, mg/kg a Ref Form g ai/kg seed days thiamethoxam CGA 224 FS 4.5 seed treatment 4 stover MW-SR-5-98 FS 4.5 seed treatment 29 stover MW-SR FS 4.5 seed treatment stover MW-SR-8-98 a In study 58-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 86 Thiamethoxam residues in maize forage and fodder resulting from supervised trials with seed treatment uses in the USA. Replicate values arise from replicate field samples MAIZE Application PHI Commodity Residue, mg/kg b, c Ref FORAGE & FODDER country, Form g ai/kg Days a thiamethoxam CGA 224 seed USA (CA), 998 FS seed treatment 6 forage (Pioneer 82) 5 stover.2. 2-SR--98 USA (IL), 998 FS 4.5 seed treatment 59 forage (Pioneer 568) 55 stover 4-SR-6-98 USA (IL), 998 FS 4.5 seed treatment 59 forage (Pioneer 568) 55 stover 4-SR-6-98 USA (Y), 998 FS.5 seed treatment 62 forage (Pioneer 568) 6 stover 5-SR--98 USA (TX), 998 FS 4.5 seed treatment 6 forage (Pioneer 94) stover..2 S-SR-2-98 USA (C), 998 FS 4.5 seed treatment 6 forage (Pioneer 94) stover S-SR-6-98 USA (IA), 998 FS 4.5 seed treatment 6 forage (Pioneer 94) stover MW-SR USA (IA), 998 FS 4.5 seed treatment 6 forage (Pioneer 94) stover MW-SR-5-98 USA (IA), 998 FS.5 seed treatment 6 forage (Pioneer 94) stover MW-SR-5-98 USA (MO), 998 (Pioneer FS 4.5 seed treatment 59 5 forage stover MW-SR ) USA (KS), 998 FS 4.5 seed treatment 6 forage (Pioneer 94) stover MW-SR--98 USA (IL), 998 (Pioneer 22) USA (IA), 998 (Pioneer 5) USA (SD), 998 (Pioneer 5) USA (E), 998 (Pioneer 5) FS 4.5 seed treatment FS 4.5 seed treatment 6 6 FS 4.5 seed treatment 6 59 FS 4.5 seed treatment 6 forage forage forage forage forage stover forage stover forage stover forage stover MW-SR MW-SR MW-SR MW-SR FS: flowable concentrate for seed treatment. Analysis for active ingredient content: 49 and 4 g.

144 9 Thiamethoxam MAIZE FORAGE & FODDER country, USA (E), 998 (Pioneer 5) USA (WI), 998 (Pioneer 5) USA (M), 998 (Pioneer 82) USA (M), 998 (Pioneer 82) USA (I), 998 (Pioneer 568) USA (I), 998 (Pioneer 94) Application PHI Commodity Residue, mg/kg b, c Ref Form g ai/kg seed Days a thiamethoxam CGA 224 FS 4.5 seed treatment 6 forage stover. FS 4.5 seed treatment 6 forage 5 stover FS 4.5 seed treatment 9 forage forage forage 6 forage 6 forage 6 stover 9 forage c. c FS 4.5 seed treatment FS 4.5 seed treatment 62 5 FS 4.5 seed treatment 62 6 USA (OH), 998 FS 4.5 seed treatment 6 (Pioneer 94) 5 USA (MI), 998 FS 4.5 seed treatment 6 (Pioneer 568) forage stover forage stover forage stover forage stover forage stover MW-SR MW-SR MW-SR MW-SR E-SR E-SR E-SR E-SR-8-98 a Interval between sowing and sampling. b c: sample from control plot. c In study 58-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 8 Thiamethoxam residues in maize fodder and forage resulting from supervised trials with seed treatment uses in France, Germany and Spain MAIZE FODDER & FORAGE country, France, 996 (Antarès) France, 996 (Bemol) France, 996 (Dunia) France, 996 (Furio) France, 99 (Antarès) Application PHI Commodity Residue, mg/kg Ref Form g ai/kg seed days a thiamethoxam CGA 224 WS. 2 2 WS WS WS WS cobs, milky stage plant without cobs cobs, silage stage plant without cobs cobs, milky stage plant without cobs cobs, silage stage plant without cobs cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks whole plant cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.4 OS9646/KJ92 OS9646/SJ9 OS9646/LD95 OS9646/AC8 9462

145 Thiamethoxam 9 MAIZE FODDER & FORAGE country, France, 99 (Bahia) France, 99 (Furio) France, 99 (Occitan) France, 998 (Bahia) France, 998 (Furio) France, 998 (Occitan) France, 999 (Anjou 5) France, 999 (Anjou 5) France, 999 (Occitan) France, 999 (Occitan) Germany, 996 (Bahia) Germany, 99 (Antarès) Germany, 99 (Antarès) Germany, 99 (Antarès) Germany, 99 (Antarès) Application PHI Commodity Residue, mg/kg Ref Form g ai/kg seed days a thiamethoxam CGA 224 WS WS WS FS.4 FS FS FS FS FS.4 FS includes fludioxonil and metalaxyl-m FS.4 FS includes fludioxonil and metalaxyl-m WS.5 (.8 kg ai/h a) WS.5 8 (. kg ai/ha 9 ) WS.5 (. kg ai/ha ) WS.5 (.99 kg ai/h 24 a) 24 FS.5 (. kg ai/ha ) whole plant cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks cobs, milky stage leaves + stalks cobs, silage stage leaves + stalks cobs, milky stage plant without cobs whole plant cobs, milky stage remaining plant cobs, milky stage remaining plant whole plant cobs plant without cobs\ cobs plant without cobs whole plant cobs remainder cobs remainder cobs, milky stage plant without cobs cobs, silage stage plant without cobs whole plant cobs remainder cobs remainder whole plant cobs remainder cobs remainder whole plant cobs remainder cobs remainder whole plant cobs remainder cobs remainder <.4 <.4 <.4 <.4 <.4 <.4 <.4 (2) <.5 (2) <.5 (2) (2) <.5 (2) (2) <.5(2) <.5 (2) <.5 (2)\ (2) <.5 (2) <.5 (2) <.5 (2) (2) <.5 (2).2 <.4 <.4 <.4 <.4 <.4 <.4 <.4 (2) <.5 (2) <.5 (2) (2) <.5 (2) (2) <.5(2) <.5 (2) <.5 (2)\ (2) <.5 (2) <.5 (2) <.5 (2) (2) <.5 (2) gr 6296 gr 89 gr 829 gr 8249 gr 89

146 92 Thiamethoxam MAIZE FODDER & FORAGE country, Germany, 99 (Antarès) Spain, 99 (Juanita) Application PHI Commodity Residue, mg/kg Ref Form g ai/kg seed days a thiamethoxam CGA 224 FS.5 (. kg ai/ha ) WS.5 (nominal) 2.4 (analysis) a Interval between sowing and sampling. whole plant cobs remainder cobs remainder cobs remainder (2) (2) (2) (2) gr /9 Table 88 Thiamethoxam residues in barley straw and fodder resulting from supervised trials in the USA. Replicate values arise from replicate field samples BARLEY STRAW & FODDER country, USA (ID), 2 (Steptoe) USA (ID), 2 (Colter) USA (ID), 22 (Eight Twelve) USA (D), 22 (Drummound) USA (D), 22 (Robust) USA (SD), 22 (Robust) USA (SD), 22 (Lacey) USA (WA), 22 (Columbia) Application PHI Commodity Residue, mg/kg Ref Form kg ai/ha kg ai/hlwater (L/ha) no. interval WG d WG.69 2 d WG d WG. 2 6 d WG. 2 6 d WG. 8 2 d WG. 8 2 d WG d days thiamethoxam CGA barley straw barley hay barley straw barley hay barley straw barley hay barley straw barley hay barley straw barley hay barley straw barley hay barley straw barley hay barley straw barley hay ID ID ID D D SD SD WA22 Table 89 Thiamethoxam residues in barley straw and fodder resulting from supervised seed treatment trials in France, Germany and the UK BARLEY Application PHI Commodity Residue, mg/kg Ref STRAW AD FODDER country, Form g ai per kg seed days a thiamethoxam CGA 224 seed treatment France, 996 WS.62 5 whole plant <.4 <.4 OS94/LD2 (Intro) sowing rate: kg seed/ha 24 barley straw <.4 <.4 France, 996 WS whole plant <.4 <.4 OS94/KJ (Labea) sowing rate: 6 kg seed/ha 264 barley straw <.4 <.4 France, 996 WS.6 2 barley straw <.5 <.5 OS9642/SJ6 (evada) sowing rate: 25 kg seed/ha France, 996 WS.62 5 whole plant <.4 <.4 OS94/AC9 (Plaisant) sowing rate: 8 kg seed/ha barley straw <.4 <.4 France, 996 WS.6 22 barley straw <.5 <.5 OS9642/AC (Prisma) sowing rate: kg seed/ha France, 996 (Prisma) WS.6 sowing rate: 2 kg seed/ha 26 barley straw <.5 <.5 OS9642/LD98

147 Thiamethoxam 9 BARLEY Application PHI Commodity Residue, mg/kg Ref STRAW AD FODDER country, Form g ai per kg seed days a thiamethoxam CGA 224 seed treatment France, 99 WS.6 whole plant <.4 <.4 94 (evada) spring barley sowing rate: 24 kg seed/ha 25 barley straw <.4.4 France, 99 (Prisma) spring barley France, 998 (Esterel) winter barley France, 998 (Gaelic) winter barley France, 998 (Maeva) winter barley France, 998 (evada) spring barley France, 998 (evada) spring barley France, 998 (Pastoral) winter barley France, 998 (Plaisant) winter barley France, 998 (Prisma) spring barley France, 998 (Prisma) spring barley France, 999 (Cork) spring barley France, 999 (Scarlett) spring barley Germany, 996 (Krona) Germany, 99 (Baronesse) spring barley UK, 996 (Optic) spring barley WS sowing rate: 85 kg seed/ha FS.6 sowing rate: 5 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.4 sowing rate: kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.6 sowing rate: 85 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS. sowing rate: kg seed/ha FS includes fludioxonil, CGA 294, flutriafol FS. 5 sowing rate: 5 kg seed/ha 89 FS includes fludioxonil, 24 cyprodinil, flutriafol FS.8 sowing rate: 2 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.6 sowing rate: 8 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS. sowing rate: 25 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.8 sowing rate: 8 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol whole plant barley straw <.4 <.4 <.4 < barley straw <.5 < barley straw <.5 < barley straw <.5 < barley straw <.5 < whole plant whole plant barley straw.5 <.5 < barley straw <.5 < barley straw <.5 < barley straw <.5 < FS.4 5 sowing rate: kg seed/ha 8 FS includes fludioxonil, cyprodinil, flutriafol 8 25 FS.6 48 sowing rate: 2 kg seed/ha 8 FS includes fludioxonil, cyprodinil, flutriafol 8 WS.6 sowing rate: 5 kg seed/ha WS sowing rate: kg seed/ha WS.56 sowing rate: 2 kg seed/ha whole plant whole plant barley straw whole plant ears stalks barley straw whole plant ears stalks barley straw <.5.. (2) <.5 (2) <.5 (2) <.5 (2) (2) <.5 (2) <.5 (2) <.5 <.5 (2) (2) <.5 (2) <.5 (2) <.5 (2) (2) <.5 (2) <.5 (2) barley straw gr whole plant whole plant whole plant barley straw.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 gr 6949 barley straw <.5 <.5 IR96

148 94 Thiamethoxam BARLEY Application PHI Commodity Residue, mg/kg Ref STRAW AD FODDER country, Form g ai per kg seed days a thiamethoxam CGA 224 seed treatment UK, 996 WS.5 8 barley straw <.5 <.5 IR296 (Optic) spring barley sowing rate: 2 kg seed/ha UK, 99 (Fighter) winter barley WS.5 22 barley straw <.5 (2) <.5 (2) OV-9825 a Interval between sowing and sampling. Table 9 Thiamethoxam residues in wheat straw and fodder resulting from supervised trials in France, Germany, Switzerland and the UK WHEAT STRAW AD FODDER Country, France, 996 (Eureka) France, 996 (Soissons) France, 996 (Soissons) soft wheat France, 99 (Ami) soft wheat France, 99 (Eureka) soft wheat France, 99 (Filou) spring wheat France, 99 (Furio) spring wheat France, 99 (Hugo) soft wheat France, 99 (Prinqual) spring wheat Application PHI Commodity Residue, mg/kg d Ref Form kg ai/hakg ai/hlwater no. Days a thiamethoxam CGA 224 (L/ha) interval WG.5. 4 whole plant.96 <.5 OI964/AC2 whole plant.5 <.5 wheat straw.22 <.5 2 wheat straw..5 WG.5. 4 whole plant. <.5 OI964/KJ6 whole plant. <.5 straw.8. 2 straw.8.6 WG.5. 4 wheat straw.5 <.5 <.5 (2) OI96 WG.5.5 wheat straw.5 <.4 92 WG WS WG WS WG st b.5. 4 st b whole plant whole plant wheat straw wheat straw whole plant whole plant whole plant wheat straw wheat straw <.4.6 <.4 <.4 <.4 whole plant <.4 whole plant.5 whole plant.8 wheat straw wheat straw 44.9 <.4 <.4 <.4 <.4 < <.4 <.4 ote 45 < WG.5. 4 wheat straw. <.4 9 WS WG st b whole plant whole plant whole plant whole plant wheat straw wheat straw < < <.4.5 < ote Wheat straw, 99 and 992. Reported values for thiamethoxam have been adjusted for average straw recovery of 6% and 99. Whole plant CGA 224 residues adjusted for average recovery = 62 %, wheat straw residues adjusted for average recovery = 68 %.

149 Thiamethoxam 95 WHEAT STRAW AD FODDER Country, France, 99 (Prinqual) spring wheat France, 99 (Soisson) soft wheat France, 99 (Soissons) soft wheat France, 99 (Texel) France, 99 (Victo) soft wheat Germany, 99 (Devon) spring wheat Germany, 99 (Devon) spring wheat Switzerland, 996 (Albis) Switzerland, 99 (Runal) UK, 99 (Riband) winter wheat UK, 99 (Riband) winter wheat UK, 99 (Riband) winter wheat Application PHI Commodity Residue, mg/kg d Ref Form kg ai/hakg ai/hlwater no. Days a thiamethoxam CGA 224 (L/ha) interval WS st b 992 WG WG whole plant whole plant whole plant whole plant wheat straw 44 wheat straw 44 whole plant whole plant wheat straw wheat straw < < <.4 <.4 <.4.5 <.4 <.4 <.4 98 WG.5. 4 wheat straw.25 <.4 9 WG whole plant whole plant straw straw <.4 <.4 <.4 <.4 98 WG.6. 4 whole plant.5 c.8.6 c <.4982 whole plant.4 <.4 wheat straw.. 2 wheat straw.6.5 WS st c - ears gr 6449 WG remainder <.5 <.5 ears.55 remainder.88 <.5 ears.2.6 remainder..6 ears..9 remainder..6 wheat straw wheat straw WS st c - ears gr 659 WG remainder <.5 <.5 ears.62 remainder.6 <.5 ears.44 remainder.6 <.5 ears.44 remainder.89.6 wheat straw wheat straw WG wheat straw /96 WG.5 5 wheat straw.5.. <.5 /96 WG wheat straw <.5 () OV-9822 WG wheat straw...5 <.5 () OV-982 WG wheat straw... <.5 () OV-9824 a PHI. Sample taken just before the final application. b st: seed treatment at.6 g ai/kg seed. 46 Wheat straw, gr 6449 and gr 659. Reported values have been adjusted for procedural recoveries, adjustment factor =.44 for thiamethoxam and.6 for CGA 224.

150 96 Thiamethoxam c st: seed treatment at.6 g ai/kg seed. d c: sample from control plot Table 9 Thiamethoxam residues in wheat straw and fodder resulting from supervised seed treatment trials in France, Germany and the UK WHEAT STRAW & FODDER Country, France, 996 (Filou) France, 996 (Furio) France, 996 (Soissons) France, 996 (Trémie) France, 99 (Florence Aurore) France, 99 (Florence Aurore) spring wheat France, 99 (Florence Aurore) spring wheat France, 99 (Prinqual) spring wheat France, 99 (Prinqual) spring wheat France, 99 (Scipion) winter wheat France, 99 (Sidéral) France, 99 (Sidéral) winter wheat France, 99 (Sidéral) winter wheat France, 99 (Soissons) winter wheat France, 99 (Vivant) winter wheat Application PHI Commodity Residue, mg/kg b Ref Form g ai per kg seed seed treatment days a thiamethoxam CGA 224 WS wheat straw <.5 <.5 OS964/AC6 sowing rate: 25 kg seed/ha WS.59 9 wheat straw <.5.5 OS964/SJ sowing rate: 25 kg seed/ha WS.59 5 whole plant <.4 <.4 OS942/AC98 sowing rate: 2 kg seed/ha 22 wheat straw <.4 <.4 WS.58 8 whole plant <.4 <.4 OS942/KJ2 sowing rate: 6 kg seed/ha 2 wheat straw <.4 <.4 WS.6 94 sowing rate: 5 kg seed/ha WS.6 sowing rate: 22 kg seed/ha FS sowing rate: 8.5 kg seed/ha 9 also contains fludioxonil, 56 difenoconazole and tefluthrin WS.6 sowing rate: 8 kg seed/ha WS.6 sowing rate: 25 kg seed/ha FS.6 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 5 whole plant whole plant whole plant wheat straw whole plant wheat straw whole plant whole plant wheat straw whole plant wheat straw whole plant wheat straw <.4 <.4 <.4 <.4 <.4 <.4 <.5.2 <.4.2 <.4 <.4 <.4 <.4 <.4 <.4 <.4 <.5.2 <.4.2 < wheat straw <.5 < WS.6 96 whole plant <.4 <.4 OS942/LD sowing rate: 6 kg seed/ha wheat straw <.4 <.4 FS wheat straw <.5 < sowing rate: 8.5 kg seed/ha also contains fludioxonil and difenoconazole FS.6 sowing rate: 8.5 kg seed/ha also contains fludioxonil, difenoconazole and tefluthrin 25 wheat straw <.5 < FS.6 2 wheat straw <.5 < sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS wheat straw <.5 < sowing rate: 6 kg seed/ha also contains fludioxonil and difenoconazole

151 Thiamethoxam 9 WHEAT STRAW & FODDER Country, France, 99 (Vivant) winter wheat France, 998 (Florence Aurore) spring wheat France, 998 (Florence Aurore) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Furio) spring wheat France, 998 (Orqual) France, 998 (Orqual) France, 998 (Prinqual) spring wheat France, 998 (Ritmo) France, 998 (Ritmo) soft winter wheat France, 998 (Sideral) France, 998 (Sideral) France, 998 (Sideral) soft winter wheat Application PHI Commodity Residue, mg/kg b Ref Form g ai per kg seed seed treatment FS.59 sowing rate: 6 kg seed/ha also contains fludioxonil, difenoconazole and tefluthrin FS.5 sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.5 sowing rate: 2 kg seed/ha also contains fludioxonil, difenoconazole FS.58 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole and tefluthrin FS.58 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.56 sowing rate: kg seed/ha also contains fludioxonil and difenoconazole FS.56 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole days a thiamethoxam CGA wheat straw <.5 < whole plant whole plant wheat straw <.5 < wheat straw <.5 < whole plant whole plant wheat straw whole plant whole plant wheat straw <.5 c.4 <.5 <.5.2 < wheat straw <.5 < wheat straw <.5 < FS.6 sowing rate: 25 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin 2 wheat straw <.5 (2) <.5 (2) 994 FS.6 wheat straw <.5 (2) <.5 (2) 9944 sowing rate: 25 kg seed/ha also contains fludioxonil, difenoconazole FS wheat straw <.5 < sowing rate: 6 kg seed/ha also contains fludioxonil and difenoconazole FS wheat straw <.5 (2) <.5 (2) 994 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS wheat straw <.5 (2) <.5 (2) 9942 sowing rate: 8 kg seed/ha also contains fludioxonil FS.6 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin FS.6 sowing rate: kg seed/ha also contains fludioxonil, difenoconazole FS.6 sowing rate: kg seed/ha also contains fludioxonil wheat straw <.5 (2) <.5 (2) wheat straw <.5 (2) <.5 (2) wheat straw <.5 (2) <.5 (2) 99422

152 98 Thiamethoxam WHEAT STRAW & FODDER Country, France, 998 (Vivant) Application PHI Commodity Residue, mg/kg b Ref Form g ai per kg seed seed treatment FS.6 sowing rate: 8 kg seed/ha also contains fludioxonil, difenoconazole, tefluthrin Germany, WS (Hanno) sowing rate 85 kg seed/ha spring wheat Germany, 99 (Hanno) spring wheat UK, 996 (Hunter) winter wheat WS.64 sowing rate 8 kg seed/ha days a thiamethoxam CGA wheat straw <.5 (2) <.5 (2) wheat straw <.5 <.5 gr whole plant whole plant whole plant wheat straw.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 gr 689 WS straw <.5 () <.5 () OV-982 a Interval between sowing and sampling. b c: sample from control plot. Table 92 Thiamethoxam residues in rice straw resulting from supervised trials in Japan RICE STRAW Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 c d (L/ha) Japan, GR a, straw.. 26-Jun-29 (Yumemizuho) SC b Japan, (Hinchikari) GR SC a b straw a Seed box treatment with granules (thiamethoxam 8 g/kg, also contains pyroquilon) at 5 g product per box. b Reverse decline trial. Plots were sprayed on separate occasions with sampling all on the same day. 26-Jun-29 c o study numbers or report numbers appeared on the documents of the trials in Japan, so they are identified by date. Table 9 Thiamethoxam residues in sugar beet leaves and tops resulting from supervised trials in France, Germany, etherlands, Spain, Sweden, Switzerland and the UK SUGAR BEET LEAVES AD TOPS Country, France, 996 (Gabriella) France, 996 (Gabriella) Application PHI Commodity Residue, mg/kg Ref Form kg ai/ha seed treatment WS.8 (8 g ai per, seeds, 2, seed per hectare) WS. (8. g ai per, seeds, 5, seeds per hectare) days thiamethoxam CGA 224 Leaves + tops (2) (2) OS964 AC 82 Leaves + tops OS964/DE2

153 Thiamethoxam 99 SUGAR BEET LEAVES AD TOPS Country, France, 996 (Gabriella) France, 99 (Anik) France, 99 (Elisa) France, 99 (Elisa) Germany, 99 (Patricia) Germany, 99 (Patricia) Germany, 998 (Patricia) etherlands, 998 (icola) Spain, 99 (Gabriela) Sweden, 998 (Patricia) Switzerland, 995 (KWS) UK, 998 (icola) Application PHI Commodity Residue, mg/kg Ref Form kg ai/ha seed treatment WS.8 (8. g ai per, seeds,, seeds per hectare) WS.5 (46 g ai per, seeds,, seed per hectare) WS.8 (59.8 g ai per, seeds,, seeds per hectare) WS. note 4 (6 g ai per, seeds, 4.25 kg seed per hectare) WS. (6 g ai per, seeds, 6, seeds per hectare) WS.6 (6 g ai per, seeds,, seeds per hectare) WS.2 (6 g ai per, seeds, 2, seeds per hectare) WS.6 (6 g ai per, seeds,, seeds per hectare) WS.5 (64 g ai per, seeds, 8, seeds per hectare) WS.2 (6 g ai per, seeds, 2, seeds per hectare) WS.9 (9 g ai per, seeds, seeds per hectare) WS (6 g ai per, seeds, sowing rate not available days thiamethoxam CGA Leaves + tops OS964/KJ9 6 Leaves + tops Leaves + tops Leaves + tops (2) (2) whole plant crowns + leaves crowns + leaves whole plant crowns + leaves crowns + leaves whole plant crowns+leaves crowns+leaves.2.2 gr 829 gr 949 gr 6298 leaves (2) (2) 6/98 85 leaves (2) (2) 8/ whole plant crowns + leaves crowns + leaves.4. gr leaves (2) 5/95 9 leaves (2) (2) 6/98 Table 94 Thiamethoxam residues in rape seed forage and fodder resulting from supervised trials in France, Germany, Sweden and the UK OILSEED Application PHI Commodity Residue, mg/kg Ref RAPE FORAGE AD FODDER Country, Form g ai per kg seed seed treatment Days a thiamethoxam CGA 224 France, 996 (Goeland) FS 4.4 sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m 62 whole plant <.5 <.5 8/9 4 Sugar beet Assume g per seeds. (Smith, 998, gr 892).

154 94 Thiamethoxam OILSEED Application PHI Commodity Residue, mg/kg Ref RAPE FORAGE AD FODDER Country, Form g ai per kg seed seed treatment Days a thiamethoxam CGA 224 France, 99 (Bristol) France, 99 (avajo) France, 99 (avajo) Germany, 99 (Evita) spring oil seed rape Germany, 99 (Evita) spring oil seed rape Germany, 998 (Evita) spring oilseed rape Germany, 998 (Laser) winter oilseed rape Germany, 998 (Laser) winter oilseed rape Germany, 998 (Licosmos) spring oilseed rape Germany, 998 (Licosmos) spring oilseed rape Sweden, 998 (Sponsor) spring oilseed rape UK, 99 (Apex) UK, 99 (Apex) FS 4.4 sowing rate: 4 kg seed/ha FS includes fludioxonil and metalaxyl-m 6 whole plant <.5 <.5 9/9 FS whole plant <.5 <.5 6/9 sowing rate:.5 kg seed/ha FS includes fludioxonil and metalaxyl-m FS 4.2 whole plant <.5 <.5 /9 sowing rate: 2.8 kg seed/ha FS includes fludioxonil and metalaxyl-m WS whole plant <.5 <.5 gr 29 sowing rate:.5 kg seed/ha 8 straw <.5 <.5 WS 5. 6 sowing rate: 4.5 kg seed/ha 4 FS 4. sowing rate: 5. kg seed/ha FS includes fludioxonil and metalaxyl-m 56 FS sowing rate:.5 kg seed/ha FS includes fludioxonil and metalaxyl-m FS sowing rate:. kg seed/ha 9 FS includes fludioxonil and metalaxyl-m FS 4.2 sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m FS 4.2 sowing rate: 6 kg seed/ha FS includes fludioxonil and metalaxyl-m FS 4. sowing rate: kg seed/ha FS includes fludioxonil and metalaxyl-m FS.8 FS includes fludioxonil and metalaxyl-m FS.8 FS includes fludioxonil and metalaxyl-m a Interval between sowing and sampling whole plant straw whole plant straw whole plant straw whole plant straw whole plant straw whole plant straw whole plant straw <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 <.5 gr 29 gr 99 gr 6299 gr gr gr gr 6898 whole plant <.5 () <.5 () 25/98 6 whole plant <.5 () <.5 () 26/98

155 Thiamethoxam 94 Table 95 Thiamethoxam residues in cotton gin by-products resulting from supervised trials in the USA. Replicate values arise from replicate field samples COTTO Application PHI Commodity Residue, mg/kg b,c Ref Country, year (variety) Form kg ai/ha a water (L/ha) no. interval days thiamethoxam CGA 224 USA (CA) 99 (Acala Maxxa) USA (CA) 99 (Acala Maxxa) USA (CA) 99 (Acala Maxxa) FS + WG FS + WG FS + WG USA (MS) FS 99 (DPL + WG 5) USA (M) FS 99 (HS- + WG 2) USA (OK) FS 99 + WG (Paymaster ) USA (TX) FS 99 (DPL + WG 5) USA (TX) FS 99 (DPL-+ WG 5) USA (TX) FS 99 (DPL-+ WG 5) USA (TX) FS 99 (DPL-+ WG 5) USA (CA) 998 (Acala Maxxa) USA (CA) 998 (Acala Maxxa) USA (CA) 998 (Acala Maxxa) USA (MS) 998 (DP 5) USA (MS) 998 (DP 5) USA (TX) 998 (DP 5) USA (TX) 998 (DP 5) FS WG g ai/kg seed.5 9 g ai/kg seed.5 9 g ai/kg seed.25 9 g ai/kg seed.5 g ai/kg seed.5 56 g ai/kg seed.5 5 g ai/kg seed.5 2 g ai/kg seed.5 84 g ai/kg seed.5 84 g ai/kg seed g ai/kg seed d + 2 d + 2 d + 2 d + 2 d + 2 d + 2 6d + 2 d + 2 d + 2 d 2 (5d) 22 gin trash R gin trash R gin trash R gin trash.. c gin trash.4. c..9 c. c R S-R gin trash S-R gin trash S-R gin trash S-R gin trash S-R gin trash S-R gin trash IR-22-98/CA WG (5d) 2 gin trash IR-22-98/CA WG (5d) 2 gin trash IR-22-98/CA FS WG g ai/kg seed (5d) 2 gin trash IR-- 98/MS WG (5d) 2 gin trash IR-- 98/MS FS WG g ai/kg seed (5d) 2 gin trash S-IR-2-98/TX WG (5d) 2 gin trash S-IR-2-98/TX

156 942 Thiamethoxam COTTO Application PHI Commodity Residue, mg/kg b,c Ref Country, year (variety) Form kg ai/ha a water (L/ha) no. interval days thiamethoxam CGA 224 USA (TX) FS 998 (DPL WG 555) g ai/kg seed (5d) 2 gin trash S-IR-6-98/TX USA (TX) WG (5d) 2 gin trash (DPL 555) S-IR-6-98/TX USA (TX) WG (5d) 2 gin trash (DPL 555) S-IR-6-98/TX USA (OK) 998 (PM 8) USA (OK) 998 (PM 8) FS WG g ai/kg seed.2 2 (5d) 24 gin trash S-IR-24-98/OK WG.45 2 (5d) 24 gin trash S-IR-24-98/OK a Study The nominal seed treatment rate, g ai/kg seed, is recorded in the table. Measured concentrations of thiamethoxam on the treated seed ranged from 2.26% to.4%, mean 2.66%, SD.22%, n = 2. b In study 4-9, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. c In study 2-98, the reported residues had been adjusted for procedural recoveries. Thiamethoxam may be used as a soil-surface application during the production of hops. A use pattern with SL formulation applied at. kg ai/ha with harvest weeks later was examined in the supervised trials in the USA on hops (Starner, 26, 845). Table 96 Thiamethoxam residues in hops resulting from supervised trials in the USA. Replicate values arise from replicate field samples HOPS Application PHI Commodity Residue, mg/kg Ref Country, For kg ai/ha a water no. days thiamethoxam CGA 224 m (L/ha) USA (ID), 22 SL dry cones ID9 (ugget) USA (OR), 22 (ugget) SL dry cones OR2 USA (WA), 22 (ugget) SL. 62 dry cones WA a Soil surface application. Thiamethoxam may be used as a foliar spray during the production of tea. In tea trials in Japan (Table 9), residue data were provided in reverse decline trials, i.e. plots were sprayed at selected time intervals and the tea leaf samples were all harvested on the same day. Immediately after harvest, the leaves were processed with an in-house tea processing machine and then enclosed in aluminium bags for delivery to the laboratory. The tea was processed in accordance with the standard tea manufacturing method using specialised equipment. Black tea is produced by first a withering process designed to remove as much moisture as possible from the tea, to prepare it for oxidation and drying. Usually, the tea leaves are spread on a wire mesh tray, and dried by hot air blowers. At this point, the leaf has become limp and turned into a darker shade of green. ext, the roller process twists and turns the leaf and breaks it, which releases the enzymes from the leaf and exposes the tissues to oxidation. After being spread on large trays, the leaf is allowed to oxidise by exposing it to air. As the leaf oxidizes, it generates heat, and slowly changes in colour from green to red to brown to eventually black

157 Thiamethoxam 94 Tea infusions were prepared by adding 5 ml of boiling water to 5 g intact crude processed tea leaves and allowing to stand for 5 minutes (akanishi, and Iwatani, 998, 6). The infusion was filtered and an aliquot was analysed for residues. Residue levels were expressed on the weight of tea leaves to prepare the infusion, allowing calculation of the rate of infusion (% of residue extracted into the boiling water). Table 9 Thiamethoxam residues in tea resulting from supervised trials in Japan TEA Application PHI Commodity Residue, mg/kg Ref c Country, Form kg ai/ha kg ai/hl water no. days thiamethoxam CGA 224 (L/ha) interval Japan, 998 SG.5 2 a crude..25 -ov-998 (Kyogen #29) processed tea leaves.84.5 Japan, 998 (Yabukita) SG.5 2 a 2 Japan, 998 SG.5 2 a (Kyogen #29) 2 Japan, 998 (Yabukita) SG.5 2 a 2 Japan, 998 SG.5 2 a (Kyogen #29) 2 Japan, 998 (Yabukita) Japan, 22 (Yabukita) Japan, 22 (Okumidori) Japan, 22 (Yabukita) Japan, 22 (Okumidori) Japan, 22 (Yabukita) Japan, 22 (Okumidori) SG.5 2 a 2 WG.5 2 a 2 WG.5 2 a 2 WG.5 2 a 2 WG.5 2 a 2 WG.5 2 a 2 WG.5 2 a 2 crude 2. processed tea. leaves.9 tea infusion b tea infusion b 6. (%). (84%).68 (94%).5 (68%).9 (4%). (9%) crude 5.5 processed tea 2. leaves.2 crude 2. processed tea.2 leaves.8 crude. processed tea. leaves. crude.9 processed tea <.5 leaves <.5 crude 8.6 processed tea 2. leaves.4 crude 2. processed tea.4 leaves.2 tea infusion b tea infusion b 8.4 (9%) 2.8 (2%).22 (88%) 2.8 (5%).45 (%).8 (2%) (96%). (92%).6 (%). (88%).6 (%).6 (%) <.5 <.5.5 (94%). (9%).5 (8%).8 (%) <.5 <.5 a Reverse decline trial. Plots were sprayed on separate occasions with sampling all on the same day. -ov-998 -Jul-998 -Jul-998 -Jul-998 -Jul Dec-22 d 26-Dec-22 d -Jul-22 -Jul-22 -Jul-22 -Jul-22 b Residue level in infusion expressed on the weight of tea leaves to prepare the infusion. Calculated rate of infusion (percentage of residue extracted into the boiling water), shown in parentheses c o study numbers or report numbers appeared on the documents, so they are identified by date. d 26-Dec-22. The data appear to be incorrect (data for thiamethoxam and CGA 224 are transposed). The trials should be considered invalid until corrected and validated. FATE OF RESIDUES I STORAGE AD PROCESSIG In processing The Meeting received information on the fate of thiamethoxam residues during the processing of apples to juice and pomace; barley to pearled barley, barley bran, barley flour, beer, wort, malt; coffee beans to roasted coffee; cotton seed to meal and refined oil; grapes to juice, pomace and wine; maize

158 944 Thiamethoxam to grits, flour, oil, starch; oranges to pulp, juice and oil; plums to dried prunes; potato to wet peelings, flakes and chips; tomatoes to juice, pulp, puree, paste; wheat to semolina, bran, flour and bread. Also information was provided on hydrolysis studies of thiamethoxam to assist with identification of the nature of the residue during processing. The data from some trials could not be used because residue levels in the raw agricultural commodity did not exceed the LOQs. Processing factors have been calculated for thiamethoxam residues during the following processes: apples processing to juice, washed apples and wet pomace; barley processing to pearled barley, bran, flour, and beer; coffee beans to roasted coffee; cotton seed to meal and oil; grapes to pomace wine; oranges to pulp, juice and orange oil; plums to dried prunes; tomatoes to juice, paste and puree; and wheat to semolina, wheat bran, wheat bead and wheat flour. Processing factors were also calculated for CGA 224 residues in the following processes: apples to apple juice and wet pomace; coffee beans to roasted coffee; plums to dried prunes; tomatoes to paste and puree. Ulbrich (998, 98UL5) measured the hydrolysis of [ C-thiazol]thiamethoxam in sterile aqueous buffers at phs and temperatures experienced during food processing and cooking. Buffers were used at a low concentration,.m, to prevent possible catalytic effects. Recoveries of total C ranged from 95 %. Very little of the thiamethoxam was hydrolysed (Table 98). Thiamethoxam was essentially stable during the hydrolysis conditions simulating food processing conditions. Table 98 Hydrolysis of [ C-thiazol]thiamethoxam under conditions representing food processes (Ulbrich, 998, 98UL5) Thiamethoxam Hydrolysis conditions Represent % thiamethoxam remaining concentration 5 mg/l ph 4 9 C 2 mins pasteurisation % 5 mg/l ph 5 C 6 mins baking, brewing and boiling % 5 mg/l ph 6 2 C 2 mins sterilisation 98.% In the hydrolysis studies on thiamethoxam, Clark (998, ABR-966) showed that CGA 224 is a minor product of thiamethoxam hydrolysis. Because little of the thiamethoxam was hydrolysed under simulated processing conditions and because CGA 224 is a minor product of thiamethoxam hydrolysis, it was assumed that very little CGA 224 should be produced during food processing. Therefore it is legitimate to calculate food processing factors for CGA 224 residues occurring in raw agricultural commodities. Kravets and Amos (2, MG68) described the processing of plums to dried prunes. Initially, a representative sample (approximately kg) of plums was taken from the lot for analysis as the raw unwashed plums. The first step in the process was to clean the lot by removing leaves, twigs and extraneous material. The next step was a cold water (approx 24 ºC) dip which allowed light extraneous material to float to the top and be removed; it also removed surface dirt. The plums were then dried in a forced air dryer (6 8 ºC) to a moisture level below 25% over 5 6 hours. The next step was storage in sweat-box conditions of 9 2 ºC for 5 days, which allowed moisture equilibration throughout the dried fruit. The prunes were then rehydrated to typical retail flesh moisture levels ( 2%) by immersion in hot water (82 84 ºC) until the desired moisture level was achieved. Residue data for the plums and dried prunes are summarised in Table 99. Table 99 Thiamethoxam and CGA 224 residues in plums and prunes from trials with thiamethoxam in the USA PLUMS Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 year (L/ha) interval (variety) USA (CA), 2 (French) WG d fruit unwashed prune IR4S

159 Thiamethoxam 945 PLUMS Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha kg ai/hlwater no. days thiamethoxam CGA 224 year (L/ha) interval (variety) USA (CA), WG (French) d USA (CA), WG d (French) USA (CA), 2 (French) WG d fruit unwashed prune fruit unwashed prune fruit unwashed prune IR4S IR4S IR4S48 Table Thiamethoxam residues in grapes and processed commodities resulting from supervised trials in Europe GRAPES Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 year (variety) (L/ha) interval France, 26 (Muscadet) WG d 2 d France, 26 (Muscadet) France, 26 (Muscadet) France, 26 (Muscadet) France, 26 (Cabernet Sauvignon) France, 26 (Cabernet Sauvignon) France, 26 (Cabernet Sauvignon) Processing replicate 2 Processing replicate Processing replicate 4 WG d 2 d Processing replicate 2 Processing replicate whole grapes must wet pomace dry pomace AF wine 48 lees sediments white wine wine, 6 months whole grapes must AF wine white wine whole grapes must AF wine white wine whole grapes must AF wine white wine whole grapes must wet pomace dry pomace AF wine MLF wine 49 lees sediments red wine wine, 6 months whole grapes must AF wine red wine whole grapes must AF wine red wine T9-6 FR-IR-6-29 plot T9-6 FR-IR-6-29 plot T9-6 FR-IR-6-29 plot T9-6 FR-IR-6-29 plot T98-6 FR-IR-6-2 plot T98-6 FR-IR-6-2 plot T98-6 FR-IR-6-2 plot 48 AF wine: wine after alcoholic fermentation. 49 MLF wine: wine after malolactic fermentation.

160 946 Thiamethoxam GRAPES Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/hakg ai/hlwater no. days thiamethoxam CGA 224 year (variety) (L/ha) interval France, 26 (Cabernet Sauvignon) Processing replicate 4 whole grapes must AF wine red wine T98-6 FR-IR-6-2 plot Table Thiamethoxam residues in maize and processed products resulting from supervised trials with seed treatment uses in the USA MAIZE Application PHI Commodity Residue, mg/kg a Ref country, Form g ai/kg days thiamethoxam CGA 224 seed USA (IA), 998 FS 45 seed (Pioneer 94) treatment USA (IA), 998 (Pioneer 94) FS 5 seed treatment 6 6 forage stover grain kernels aspirated grain fractions meal large grits medium grits small grits flour refined oil, dry milling starch refined oil, wet milling forage stover grain kernels aspirated grain fractions meal large grits medium grits small grits flour refined oil, dry milling starch refined oil, wet milling MW-SR MW-SR-5-98 a In study 58-98, the reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. Table 2 Thiamethoxam and CGA 224 residues in oranges, apples, grapes, tomatoes, potatoes, barley, wheat, cotton and coffee and their processed commodities resulting from trials with thiamethoxam. Data on residues in the raw agricultural commodities in these trials are separately recorded in the section on supervised residue trials CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval ORAGE PROCESSIG USA (FL), 25 (Valencia) orange WG.96 2 d dried pulp oil juice.4. T VK-IR-5-69

161 Thiamethoxam 94 CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (FL), 25 (Valencia) orange WG.48 2 d dried pulp oil juice not analysed not analysed not analysed not analysed.... c. T VK-IR-5-69 USA (CA), 25 (Cutter Valencia) orange WG d APPLE PROCESSIG France, 99 WG. 2 (Idared) d Italy, 99 (Stark Spur Red) Italy, 99 (Jonagold) USA (WA), 996 (Red Delicious) apple USA (WA), 996 (Red Delicious) apple USA (WA), 996 (Red Delicious) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple USA (Y), 996 (McIntosh) apple WG. 2 2 d WG. 5 2 d WG a WG. +.5 a WG a WG a WG. +.5 a WG a GRAPES PROCESSIG Switzerland, 22 (Pinot oir) WG.5 5 2d 2d Switzerland, 22 (Chasselas) France, 22 (Cabernet Franc) WG.5 5 2d 22d WG d 2 2d dried pulp oil juice 2 apples apple juice apple puree apple pomace apples.2 juice.2 wet pomace (5%. DM) apples.2 juice wet pomace (24%.4 DM) 5 apples, unwashed apples, washed wet pomace apple juice 5 apples, unwashed apples, washed wet pomace apple juice 5 apples, unwashed apples, washed wet pomace apple juice apples, unwashed apples, washed wet pomace apple juice apples, unwashed apples, washed wet pomace apple juice apples, unwashed apples, washed wet pomace apple juice 2 berries juice pomace wine 2 berries juice pomace wine 22 berries juice juice pomace pomace wine wine (2) (2) <.5. <.5.2 <.5 (2) (2) (2) T WC-IR /9 6/9 ABR-9896 W-IR ABR-9896 W-IR ABR-9896 W-IR ABR IR-4-96 ABR IR-4-96 ABR IR

162 948 Thiamethoxam CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval France, 22 WG (Grenache, red) 2d 2d 22 TOMATO PROCESSIG Italy, 99 (986) WG. 6 2 d Italy, 99 (S Marzano) WG. 2 2 d Italy, 99 WG. 2 (Cuor di bue) d greenhouse Spain, 99 (Rento) USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (Rio Grande) tomato USA (CA), 996 (8892) tomato USA (CA), 996 (8892) tomato WG. 2 2 d WG d WG d WG d WG d WG d WG d WG d WG d berries berries juice juice pomace pomace wine wine fruit tomato juice preserves tomato pulp fruit tomato juice preserves tomato pulp fruit fruit, peeled fruit, washed tomato juice preserves tomato pulp fruit fruit, peeled fruit, washed tomato juice preserves tomato pulp fruit fruit, washed tomato puree tomato paste fruit fruit, washed tomato puree tomato paste fruit fruit, washed tomato puree tomato paste fruit fruit, washed tomato puree tomato paste fruit fruit, washed tomato puree tomato paste fruit fruit, washed tomato puree tomato paste fruit, process fruit, washed tomato puree tomato paste 9 fruit, process fruit, washed tomato puree tomato paste (2) (2) < (2) (2) (2) (2) (2) <. (2) /9 8/9 9/96 69/96 ABR IR-9-9 b ABR IR-9-9 b ABR IR-9-9 b ABR IR-9-9 b ABR IR-9-9 b ABR IR-9-9 b ABR-985 W-IR b ABR-985 W-IR b

163 Thiamethoxam 949 CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval USA (CA), 996 (8892) tomato WG. 2 5 d fruit, process fruit, washed tomato puree tomato paste ABR-985 W-IR b USA (CA), 996 (8892) tomato USA (CA), 996 (8892) tomato USA (CA), 996 (8892) tomato WG. 2 5 d WG d WG d POTATO PROCESSIG USA (ID), 998 (Ranger Russet) WG.99 2 d USA (ID), WG (Ranger d Russet) USA (ID), 998 (Ranger Russet) 9 fruit, process fruit, washed tomato puree tomato paste fruit, process fruit, washed tomato puree tomato paste 9 fruit, process fruit, washed tomato puree tomato paste tuber, to process wet peelings flakes chips 5 tuber, to process wet peelings flakes chips 5 FS.2 spt8 tuber, to process wet peelings flakes chips UK, 99 WG (Maris Piper) d tubers tubers () () () () ABR-985 W-IR b ABR-985 W-IR b ABR-985 W-IR b W-SR-6-98 b W-SR-6-98 b W-SR-6-98 b OV-98 boiled potato peeled potato crisp French fry BARLEY PROCESSIG USA (ID), 22 (Eight Twelve) WG d France, 998 (Esterel) winter barley France, 999 (Cork) spring barley FS.6 sowing rate: 5 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol FS.4 sowing rate: kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol boiled potato peeled potato crisp French fry 2 barley grain pearled barley barley bran barley flour 262 barley grain beer wort malt 25 barley grain beer wort malt (2) <.5 (2) 46.2-ID Potato processing, 59-98, W-SR Residues of thiamethoxam and CGA 224 were detected in control and treatment chip samples by HPLC-UV analysis, but no residues were detected on LC-MS analysis.

164 95 Thiamethoxam CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval France, (Scarlett) spring barley FS.6 sowing rate: 2 kg seed/ha FS includes fludioxonil, cyprodinil, flutriafol WHEAT PROCESSIG Germany, WS st d 99 (Devon) WG spring wheat.5 4 Germany, WS 99 (Devon) WG spring wheat st d.5 4 COTTO PROCESSIG USA (CA) 99 (Acala Maxxa) FS + WG g ai/kg seed.5 9 USA (CA) 99 (Acala Maxxa) USA (CA) 99 (Acala Maxxa) USA (TX) 99 (DPL- 5) USA (TX) 99 (DPL- 5) USA (TX) 99 (DPL- 5) USA (CA) 998 (Acala Maxxa) USA (CA) 998 (Acala Maxxa) USA (TX) 998 (DPL 555) USA (TX) 998 (DPL 555) FS + WG FS + WG FS + WG FS + WG FS + WG g ai/kg seed.5 9 g ai/kg seed.25 9 g ai/kg seed.5 84 g ai/kg seed.5 84 g ai/kg seed d + 2 d + 2 d + 2 d + 2 d barley grain beer wort malt wheat grain semolina bran flour bread wheat grain 5 semolina bran flour bread 22 cotton seed hulls meal oil, refined 22 cotton seed hulls meal oil, refined 22 cotton seed hulls meal oil, refined 2 cotton seed hulls meal oil, refined 2 cotton seed hulls meal oil, refined 2 cotton seed hulls meal oil, refined + 2 d WG (5d) 2 cotton seed hulls meal refined oil WG (5d) 2 cotton seed hulls meal refined oil WG (5d) 2 cotton seed hulls meal refined oil WG (5d) 2 cotton seed hulls meal refined oil (2) < < \.2 (2) <. gr 6449 gr R-8-9 b R-8-9 b R-8-9 b 4-9 S-R-8-9 b 4-9 S-R-8-9 b 4-9 S-R-8-9 b IR-22-98/CA c IR-22-98/CA c 2-98 S-IR-6-98/TX c 2-98 S-IR-6-98/TX c 5 Wheat grain and bran, gr 659. Reported values have been adjusted for procedural recoveries, adjustment factor =.68 for thiamethoxam.

165 Thiamethoxam 95 CROP Application PHI Commodity Residue, mg/kg Ref Country, Form kg ai/ha water no. days thiamethoxam CGA 224 (L/ha) interval Greece, 99 WS 2. ST 96/9 (Eva) WG.5 9 Greece, 99 (Eva) Greece, 998 (Korina) Greece, 998 (24 Stoneville) WS WG Greece, 999 WS (ETH.I.AG.E-WG ) Greece, 999 WS (ETH.I.AG.E-WG ) 2.6 ST.5 + d + d WG.5 6 d WG.5 6 d.9 ST ST.5 5 COFFEE PROCESSIG Brazil (MG), WG. e (Mundo WG +.5 ovo) soil drench Brazil (MG), WG. e soil (Mundo drench ovo) Brazil (MG), WG.5 soil (Mundo drench ovo) +, d dehulled seed cotton hulls cotton seed oil presscake dehulled seed cotton hulls cotton seed oil presscake dehulled seed cotton hulls crude oil presscake dehulled seed cotton hulls crude oil presscake (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) dehulled seed (2) cotton hulls <.5 (2) dehulled seed (2) cotton hulls crude <.5 (2) oil (2) flour/cake (2) +, d dehulled seed cotton hulls crude oil flour/cake 2 9 d 9 9 coffee beans roasted coffee coffee beans roasted coffee coffee beans roasted coffee Brazil (MG), (Mundo ovo) control plot () coffee beans () roasted coffee Brazil (MG), WG. e soil 2 coffee beans (Catuai) WG +.5 drench 9 d roasted coffee Brazil (MG), WG. e soil 9 coffee beans (Catuai) drench 9 roasted coffee Brazil (MG), WG.5 soil coffee beans (Catuai) drench roasted coffee Brazil (MG), control () coffee beans (Catuai) plot () roasted coffee Brazil (MG), WG. e soil 2 coffee beans (Catuai) WG +.5 drench 9 d roasted coffee Brazil (MG), WG. e soil 9 coffee beans (Catuai) drench 9 roasted coffee Brazil (MG), WG.5 soil coffee beans (Catuai) drench roasted coffee Brazil (SP), WG. e soil 2 coffee beans (Mundo WG +.5 drench 9 d roasted coffee ovo) Brazil (SP), WG. e soil (Mundo drench ovo) Brazil (SP), (Mundo ovo) WG.5 soil drench 9 9 coffee beans roasted coffee coffee beans roasted coffee (2) <.5 (2) (2) (2)..5.4 c. c..5.5 c.4 c (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) <.5 (2) (2) (2) (2) <.5 (2) (2) (2)...2 c.2 c...2 c.2 c /9 65/98 66/98 4/99 5/99 M92 trial JJB M92 trial JJB M92 trial JJB M92 trial JJB M92 trial JJB2 M92 trial JJB2 M92 trial JJB2 M92 trial JJB2 M92 trial JJB4 M92 trial JJB4 M92 trial JJB4 M92 trial LZF M92 trial LZF M92 trial LZF

166 952 Thiamethoxam a Applied as a tank-mix with pymetrozine b The reported individual residue results had been adjusted for procedural recovery where it was less than % for that set of analyses. c Reported residues had been adjusted for procedural recoveries. d st: seed treatment at.6 g ai/kg seed e Trial results are suspect because of significant residues in samples from the control plot Table Summary of processing factors for thiamethoxam and CGA 224 residues. The factors are calculated from the data recorded in tables in this section. 'Less than values' (<) occur when the residue in the processed commodity is reported as less than the LOQ Raw agricultural commodity (RAC) Processed commodity Calculated processing factors. Median or best estimate THIAMETHOXAM Apple apple juice.2,.2,.8,.92,.94,., <.,.4.9 Apple washed apples.5,.5,.65,.8,.8,.85. Apple wet pomace.8,.8,.4,.5,.6,.6,.9, Barley barley bran.. Barley barley flour.8.8 Barley beer <.5 inadequate Barley malt < inadequate Barley pearled barley Barley wort <.5 inadequate Coffee beans roasted coffee <., <., <., <.2, <.2, <.2, <.25, <.25, <.25, <., <., <.5 <. Cotton seed cotton seed meal.5,.2,.2, <.,.49.2 Cotton seed cotton seed oil refined, <.8, <.9, <.2, <. Grapes dry pomace.4, Grapes must.,.95,.9,.,.,.2,.4,.6.5 Grapes wet pomace.,.5, 4..5 Grapes wine.,.,.9,.,.5,.,.6,.6,. Orange dried pulp 2., Orange orange juice <.25, <.5 <.25 Orange orange oil <.25, <.5 <.25 Plum dried prunes.6,.8, <..8 Tomato tomato juice.6, <..6 Tomato tomato paste.25, 2., 2.24, 2.4, 2.94, 2.94,.,.86,.9, 4.2, 4., 6.. Tomato tomato pulp.,.. Tomato tomato puree.4,.5,.64,.9,.6,.2,.,.5,.8, 2., 2.2, 2.5. Tomato washed tomatoes.8,.24,.,.4,.5,.5,.52,.52,.5,.6,.5, <.<.,.5 Wheat semolina <. <. Wheat wheat bran Wheat wheat bread <. <. Wheat wheat flour <. <. CGA 224 Apple apple juice.,.,.-. Apple washed apples.5,.6,..6 Apple wet pomace.4,,5,.5.5 Coffee beans roasted coffee <., <., <., <., <., <.5, <.5, <.5, <.5, <.5 <. Plum dried prunes.5, 2..5 Tomato tomato paste 2., 2.8,.,.5, 5.5, 5.8, 6., 6., 6.5, 6.5, 9.,. 5.9 Tomato tomato puree.5,.6,.,.9,.,.5, 2.5, 2.5,.,.44,.54, 6., 2. Tomato washed tomatoes.9,.5,.5,.5,.56,.5,.5,.,.8,.,.4, 2.,.5

167 Thiamethoxam 95 RESIDUES I AIMAL COMMODITIES Livestock feeding studies The meeting received a lactating dairy cow feeding study, which provided information on likely residues resulting in animal tissues and milk from thiamethoxam residues in the animal diet. Lactating dairy cows Groups of three lactating Holstein dairy cows (animals weighing 5 58 kg and kg on days and 29 respectively) were dosed once daily via gelatin capsule with thiamethoxam at 2 ppm ( ), 6 pm ( ) and 2 ppm ( ) in the dry-weight diet, equivalent to doses of.9,.24 and.8 mg thiamethoxam per kg body weight, for consecutive days (Campbell, 998, ABR-9852). Milk was collected on seven occasions for analysis (days,,,,, 2 and 26), as a composite of AM and PM milking for the day for each animal. On days 29 and, the animals were slaughtered for tissue collection. Animals were slaughtered within 2 24 hours of the final dose. Tissues collected for analysis were liver, kidney, perirenal fat, omental fat, round muscle, and tenderloin muscle. Animals consumed approximately 2 kg dry feed each per day and produced approximately kg milk per animal per day. Parent thiamethoxam residues did not occur above LOQ in liver or fat tissues for the highest test dose (Table ). Metabolite CGA 224 did not occur above LOQ (. mg/kg) in any of the tissues except liver. Parent thiamethoxam residues were higher in muscle than in other tissues, but levels were below LOQ (. mg/kg) at the 2 ppm dosing level. Residue levels of parent thiamethoxam and metabolite CGA 224 apparently reached plateau levels in milk about 5 days after the commencement of dosing. Lin and Oakes (22, ABR-9852-Am) used a microwave extraction procedure on liver, which was found to release residues of metabolite CGA 224. The microwave procedure is summarised in this evaluation under analytical methods (Lin, 22, 26-9). Table Residues in milk and tissues of lactating Holstein dairy cows ( per group) dosed once daily via gelatin capsule with thiamethoxam at the equivalent of 2 ppm ( ), 6 ppm ( ) and 2 ppm ( ) in the dry-weight diet, for consecutive days (Campbell, 998, ABR-9852) Substrate Residues, mg/kg individual animals Dosing, 2 ppm Dosing, 6 ppm Dosing, 2 ppm thiamethoxam CGA 224 thiamethoxam CGA 224 thiamethoxam CGA 224 Tenderloin muscle () ().. ().2.4. () Round muscle () (). ()..6. () Liver () () () () () () Liver ote a () ()..9. ()...8 Kidney () () () ()..4. () Omental fat () () Perirenal fat () () Milk, day <.5 () <.5 () <.5 () <.5 () <.5 () <.5 () Milk, day.6.9 < < <.5 Milk, day <.5. <.5 () Milk, day.. < <.5 Milk, day.8. <.5 () Milk, day 2... <.5 ()

168 954 Thiamethoxam Substrate Residues, mg/kg individual animals Dosing, 2 ppm Dosing, 6 ppm Dosing, 2 ppm thiamethoxam CGA 224 thiamethoxam CGA 224 thiamethoxam CGA 224 Milk, day <.5 () a Residues in liver measured after microwave extraction (Lin and Oakes, 22, ABR-9852-Am). RESIDUES I FOOD I COMMERCE OR AT COSUMPTIO o information was available. ATIOAL RESIDUE DEFIITIOS The following national residue definitions for thiamethoxam were available to the Meeting. Australia Commodities of plant origin: thiamethoxam. Commodities of animal origin: Sum of thiamethoxam and -(2-chloro-thiazol-5-ylmethyl)-'-methyl- '-nitro-guanidine, expressed as thiamethoxam. (FSAZ, 2). Canada -[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl--nitro-4H-,,5-oxadiazin-4-imine, including the metabolite (E)--[(2-chloro-5-thiazolyl)methyl]-'-methyl-"-nitroguanidine. (Canada, 2). Brazil Thiamethoxam: sum of thiamethoxam and clothianidin expressed as thiamethoxam. EU Thiamethoxam (enforcement and risk assessment, plants and animals): sum of thiamethoxam and clothianidin expressed as thiamethoxam. Japan Thiamethoxam: (for crops for which both a pesticide containing thiamethoxam as active ingredient and the other containing clothianidin are registered for use, there is a specific residue definition established for clothianidin, taking into consideration these pesticides may be used on the crops in the same lot. Clothianidin: sum of clothianidin arising from the use of pesticide(s) containing clothianidin and clothianidin arising from the use of pesticide(s) containing thiamethoxam). ew Zealand Thiamethoxam USA Thiamethoxam: combined residues of thiamethoxam and its metabolite calculated as parent equivalents.

169 Thiamethoxam 955 APPRAISAL Residue and analytical aspects of thiamethoxam were considered for the first time by the present meeting. Thiamethoxam (ISO common name), a nicotinoid compound, has broad spectrum activity against sucking and chewing insects in vegetables, ornamentals, field crops, deciduous fruits, citrus, cotton and rice. It possesses contact and stomach O Cl activity. Its activity against foliar feeding insects after seed treatment, after application to the soil, through irrigation systems, or when applied to the S trunks of trees, results from its systemic properties. It is also registered for direct foliar application. O 2 The IUPAC name for thiamethoxam is (EZ)--(2-chloro-,-thiazol-5-ylmethyl)-5-methyl-,,5-oxadiazinan-4-ylidene(nitro)amine and the CA name is -[(2-chloro-5- thiazolyl)methyl]tetrahydro-5-methyl--nitro-4h-,,5-oxadiazin-4-imine. Thiamethoxam labelled either in the 2-position of the thiazole moiety or on the carbon of the guanidine moiety (4-oxadiazine label) was used in the metabolism and environmental fate studies. Animal metabolism Information was available on metabolism of thiamethoxam in laboratory animals, lactating goats and laying hens. When rats were orally dosed with labelled thiamethoxam, 8% of the dose was eliminated in the urine as parent thiamethoxam. The main metabolite in urine was CGA 224 (-(2- chlorothiazol-5-ylmethyl)-'-methyl-"-nitroguanidine) accounting for approximately % of the dose. umerous low-level metabolites were identified. Metabolism in laboratory animals was summarised and evaluated by the WHO panel of the JMPR in 2. When lactating goats were orally dosed with labelled thiamethoxam, approximately % of the dose appeared in the milk and 4% in the tissues. Metabolite CGA 224 was the major component (44% and 45%) of the residue in milk, while parent thiamethoxam was the major component in goat fat (6% and 52%), muscle (5% and 54%) and kidneys (2% and 22%). Products of further metabolism occurred in the goat liver. OA 4226 (-(2-chlorothiazol- 5-ylmethyl)-guanidine), OA 4225 (-(2-chlorothiazol-5-ylmethyl)-'-methyl-guanidine), L (2- oxopropionic acid [-(2-chloro-thiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-ylidene]- hydrazide) and OA 445 (-(2-chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4- ylidineamine) were metabolites found at levels exceeding % TRR in the liver. Parent thiamethoxam and CGA 224 were present in liver tissue at approximately % and 6 % of TRR respectively. When laying hens were dosed with labelled thiamethoxam, most of the dose was excreted in the droppings. Eggs accounted for approximately.% of the administered dose and tissues approximately.5%. Parent thiamethoxam was not the major component of the residue in any hen tissue or eggs, but did constitute approximately 2% TRR in lean meat, 5 5% in fat + skin, 2 5% in egg white and % in egg yolks. Metabolite CGA 265 (-(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine) was the major residue component in the eggs, both whites (45% and 4%) and yolks (69% and 54%), and also in fat + skin (54% and 5%). Metabolite CGA 224 was the major residue component in hen liver (4% and 9%) while metabolite MU (amino-([(2-chlorothiazol-5-ylmethyl)-amino]-methylene)- hydrazide) was the major component of the lean meat residue (9% and %).

170 956 Thiamethoxam Other metabolites present at more than % TRR were: OA 4225 (-(2-chlorothiazol-5- ylmethyl)-'-methyl-guanidine) in lean meat, MU in hen liver, CGA 224 and OA 446 (- (2-chloro-thiazol-5-ylmethyl)--nitrourea) in egg white and CGA 224 in egg yolk. Animal metabolism summary When animals were orally dosed with labelled thiamethoxam, the C was readily excreted in urine and faeces and an array of metabolites was produced. In lactating goats, metabolite CGA 224 was the major component of the residue in milk, while parent thiamethoxam was the major component in muscle, fat and kidney. Further degraded metabolites occurred in the liver. Metabolite OA 4226 was the major identified component of the residue in goat liver. In laying hens, parent thiamethoxam was not the major component of the residue in any tissue or eggs, but did constitute approximately 2% of the C in lean meat. Metabolite CGA 265 was the major residue component in the eggs and in fat + skin. Metabolite CGA 224 was the major residue component in liver while metabolite MU was the major component of the lean meat residue. Plant metabolism Information was available on the metabolism of thiamethoxam in maize, rice, pears, cucumbers, lettuce and potatoes. When maize seeds treated with [ C-oxadiazin]thiamethoxam were sown and grown through to maturity, C residues were detected in whole tops (day after sowing), forage (day 24) and grain and fodder (maturity, day 66). The TRR level of 8 mg/kg in the whole tops with 4% TRR identified as thiamethoxam demonstrated that thiamethoxam is readily taken up and translocated. Parent thiamethoxam was the major identified component of the residues in whole tops and maize grain. Metabolite OA 4225 (-(2-chlorothiazol-5-ylmethyl)-'-methyl-guanidine) was the major identified component of the forage and fodder. Metabolite CGA 224 constituted approximately % TRR in forage and grain. In the companion maize seed metabolism study, maize seeds treated with [ C- thiazolyl]thiamethoxam were sown and grown through to maturity. C residues were detected in tops (day after sowing), forage (day 24) and grain and fodder (maturity, day 66). Parent thiamethoxam was the major component of residues in the tops (4% TRR). Metabolites appearing as % or more of TRR were: OA 445 (-(2-chlorothiazol-5-ylmethyl)-5-methyl- [,,5]oxadiazinan-4-ylidineamine) in tops, CGA 224 and OA 4225 in forage and OA 4225 in fodder. In the grain, 65% of TRR was unextracted; thiamethoxam and CGA 224 were the only identified residue components. In a soil treatment maize experiment, [ C-oxadiazin]thiamethoxam was applied to the soil around maize plants at the 2 leaf stage. Parent thiamethoxam and CGA 224 were the major identified components of the residues in 89 days forage and grain. Metabolite -methyl-- nitroguanidine at approximately % TRR was the major identified component of the fodder. The companion soil treatment study with [ C-thiazolyl]thiamethoxam again found that thiamethoxam and CGA 224 were the major identified components in the forage and grain. OA 4225 at approximately % TRR was the major component of the fodder. In a rice metabolism study, [ C-oxadiazin]thiamethoxam was formulated as granules and applied to the seedling box 24 hours before planting out. A parallel experiment was run with [ C- thiazolyl]thiamethoxam. Release of C into the paddy water was rapid and the radiolabel was readily translocated to all parts of the plant. Thiamethoxam was the major component of the residues in the early stages. At maturity, parent thiamethoxam was not identified in the grain, when 88% TRR was unextracted. Metabolites CGA 224 and -methylurea were the major identified components of the rice grain residues but at only 2% TRR. Parent thiamethoxam and CGA 559 (-(2- chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-one) were the main components of the straw residues while thiamethoxam and CGA 224 were the main components in the husks.

171 Thiamethoxam 95 In a separate rice metabolism study, [ C-oxadiazin]thiamethoxam formulated as a WP was applied twice as foliar treatments at booting stage and 5 days later. A parallel experiment was run with [ C-thiazolyl]thiamethoxam. Parent thiamethoxam was the major identified component in grain (% and 4.5%), husks (65% and%) and straw (5% and.5%) with CGA 224 the second largest identified component. The non-extracted component in the grain accounted for 6% and 9% of the TRR. The non-extracted C in grains, husk and straw was found to be incorporated into starch, cellulose, hemicellulose or proteins. Pears were subject to foliar sprays with [ C-oxadiazin]thiamethoxam and [ C- thiazolyl]thiamethoxam formulated as WPs two cover sprays, days apart with the final spray 5 days before harvest. For each treatment and application rate, thiamethoxam and CGA 224 were the major identified components of the residues in fruit, together accounting for approximately 5% of the TRR. one of the other metabolites exceeded % TRR. Cucumber plots were subject to foliar sprays with [ C-oxadiazin]thiamethoxam and [ C- thiazolyl]thiamethoxam formulated as WPs first spray at full flowering and the second days later, days prior to mature harvest. OA 445 (-(2-chlorothiazol-5-ylmethyl)-5-methyl- [,,5]oxadiazinan-4-ylidineamine) and thiamethoxam were the major identified components of the residues in cucumbers, together accounting for approximately 4% the TRR. CGA 224 and other metabolites were minor components, each accounting for less than 2% TRR. Field grown lettuce were subject to foliar sprays with [ C-oxadiazin]thiamethoxam and [ C- thiazolyl]thiamethoxam formulated as WGs three times at weekly intervals. Parent thiamethoxam was the major component of the residues accounting for approximately 4% of the residues days after the final treatment. umerous metabolites were identified, but at day none exceeded 8% of the TRR. The non-extracted residue fraction accounting for % and 9% of TRR was subjected to vigorous treatment and extraction, which released C material of a very polar nature believed to be derived from natural plant components. In a potato metabolism study, potato seed-pieces treated with [ C-thiazol]thiamethoxam and [ C-oxadiazin]thiamethoxam were sown and the potatoes were grown to new potato size (84 days after sowing) and maturity (6 days). Parent thiamethoxam was the major identified residue in the harvested potatoes at 2% of TRR. Metabolite CGA 224 was present at 6 % of TRR. Metabolite CGA 29 (,6-dihydro- -methyl--nitro-2h-,,5-oxadiazin-4-amine) constituted approximately 6 % TRR while CGA 49 (2-chloro-5-thiazolemethanol) and its conjugate also accounted for approximately 6 % TRR. A number of other metabolites were identified, but none exceeded % TRR. Plant metabolism summary Thiamethoxam was readily taken up from treated seed, treated soil or sprayed foliage and translocated within the plant and it produced many metabolites. Parent thiamethoxam was usually an important component of the residues. Metabolic degradation pathways were similar in the various plants tested: maize, rice, pears, cucumbers, lettuce and potatoes. Parent thiamethoxam and metabolite CGA 224 appeared in plant metabolism profiles above % TRR more often than other metabolites. Other metabolites to appear above % TRR at least once were: -methylguanidine, CGA 29, CGA 559, OA 445 and OA nitroguanidine was the only plant metabolite (identified in lettuce at..5% TRR) that did not also appear as an animal metabolite. -nitroguanidine may occur from other sources it is an industrial chemical with uses in the explosives industry and as a chemical intermediate in the manufacture of pharmaceuticals.

172 958 Thiamethoxam Environmental fate in soil Information was available on aerobic soil metabolism for thiamethoxam, CGA 224, CGA 559 (-(2-chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-one) and OA 445 (-(2- chlorothiazol-5-ylmethyl)-5-methyl-[,,5]oxadiazinan-4-ylidineamine). Studies on rice paddy metabolism, soil surface photolysis and rotational crops were also provided. Soil metabolism and photolysis When labelled thiamethoxam was incubated in soils under aerobic conditions at 2 C and 4% max water capacity, its half-life ranged from 8 to days. Higher temperatures or higher moisture levels increased the rate of disappearance. CGA 224 and CGA 559 were usually the main identified soil metabolites. After 8 days, approximately 2 2% of the dose had been mineralized and 6% was unextracted. When labelled CGA 224 was incubated in soils under aerobic conditions at 2 C and 4% max water capacity, its half-life was approximately days. The half-life for labelled CGA 559 under these same conditions was 5 days. When [ C-thiazol]thiamethoxam was exposed to a paddy soil system at 25 C, thiamethoxam disappeared with a half-life of approximately 5 days. The main metabolite was OA 445, produced under the reducing conditions of the paddy soil. OA 445 was quite persistent at 2 C and 4% max water capacity in soils under aerobic conditions, with % and 86% of the dose remaining after a test of 8 days (estimated half-life exceeding days). In a days study with the soil photolysis of labelled thiamethoxam at 25 C and 5% field moisture capacity, the amount remaining after photolysis was 66% and 59% compared with the dark controls 8% and 8%. CGA 224 and CGA 559 were the main products identified. Soil metabolism summary When labelled thiamethoxam was incubated in soils under aerobic conditions at 2 C, its half-life varied from 8 to days. In 6 months of incubation, the percentage of dose mineralized was approximately 2 to 2% and the percentage that was unextracted was approximately to 6%. The main soil metabolites identified were: CGA 224 (-(2-chlorothiazol-5-ylmethyl)-'- methyl-"-nitroguanidine) and CGA 559 (-(2-chlorothiazol-5-ylmethyl)-5-methyl- [,,5]oxadiazinan-4-one). Metabolite OA 445 (-(2-chlorothiazol-5-ylmethyl)-5-methyl- [,,5]oxadiazinan-4-ylidineamine) was identified under rice paddy conditions. The disappearance of thiamethoxam under soil photolysis conditions was faster than in the dark controls but the main products were CGA 224 and CGA 559, the same as for soil metabolism. Rotational crops When lettuce, radish and wheat were grown in a rotational crop situation 29, 9 and 62 days after treatment of bare ground with labelled thiamethoxam at.2 kg ai/ha, TRR levels were generally low:.5 mg/kg and below for lettuce;.2 mg/kg and below for radish tops;. mg/kg and below for radish roots and.5 mg/kg and below for wheat grain. Higher TRR levels were found in wheat straw:.5.5 mg/kg. Parent thiamethoxam was the most commonly detected component of the residue and was present at higher concentrations (up to.2 mg/kg) than other components in lettuce and radish. In wheat straw and grain, parent thiamethoxam (up to.8 mg/kg in straw and.2 mg/kg in grain) and metabolite CGA 224 (up to.44 mg/kg in straw and. mg/kg in grain) were the most commonly detected. However, in some cases other metabolites were present at higher levels: CGA 265 (-(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine) in wheat grain and - methylguanidine (CGA 829), OA 452 (-nitro-'-methylguanidine), OA 4225 (-(2-

173 Thiamethoxam 959 chlorothiazol-5-ylmethyl)-'-methyl-guanidine) and CGA 265 (-(2-chlorothiazol-5-ylmethyl)- '-nitroguanidine) in wheat straw. Residues of parent thiamethoxam and some metabolites could occur in rotational crops, but generally at very low levels. Detections would be unlikely except for residues in commodities such as wheat straw, which will be covered by MRLs in any case because of approved direct uses. Additional information relevant to CGA 224 fate and behaviour is available in the clothianidin rotational crop studies. Methods of residue analysis Analytical methods and validation data for residues of thiamethoxam and CGA 224 in animal and plant matrices were made available to the Meeting. Methods had been subjected to independent laboratory validation. Analytical recovery data for thiamethoxam and CGA 224 at residue concentrations on numerous substrates were available to the Meeting. Residues of parent thiamethoxam and metabolite CGA 224 in plant and animal matrices may be analysed by HPLC-MS or HPLC-UV with an LOQ of. mg/kg after a series of cleanup steps. In method AG-65, which relies on acetonitrile-water for sample extraction, a microwave extraction procedure is necessary for good extraction of residues from some animal commodities, especially liver. Analysis of residues in liver was not possible with the HPLC-UV finish because of too many interfering peaks, but was successful with the LC-MS/MS finish. Samples with incurred residues from the metabolism studies were analysed by method AG- 65, but interpretation was difficult because of uncertainties in the data (some concentrations below.5 mg/kg). For pears and cucumbers, the analytical method concentration of thiamethoxam was approximately 4 9% of the metabolism value. For thiamethoxam in goat meat, the analytical method result was 56 9% of the metabolism result. The thiamethoxam concentration in goats milk, measured by method AG-65 was only about 2% of the value from the metabolism study. In each of these tests, the results for CGA 224 were similar to those for thiamethoxam. However, the data were from different laboratories on samples with different storage histories, making interpretation difficult. Supporting information relevant to the efficient extraction of CGA 224 from milk and other matrices by acetonitrile-water is provided in the clothianidin studies on samples with incurred residues from clothianidin metabolism studies. This information on efficient extraction of CGA 224 residues would also support the efficient extraction of thiamethoxam residues, which had behaved similarly but erratically, in the thiamethoxam studies. Method REM-9 versions were used for analysis of plant commodities. Samples are homogenized and extracted with water + methanol. Cleanup is affected by solvent partition and cartridge columns. Pears from the metabolism study were extracted and analysed by method REM 9. for comparison with the C measurements. Measured concentrations of thiamethoxam in the pear were.96,. and. mg/kg for the original metabolism study, by radiolabel analysis on the LC fraction and by HPLC-UV respectively. Similarly, measured concentrations of CGA 224 (expressed as thiamethoxam) were.4,.85 and.5 mg/kg for the same three situations. Thiamethoxam, CGA 224 and CGA 265 (-(2-chlorothiazol-5-ylmethyl)-'- nitroguanidine) were not suitable analytes for the multiresidue methods tested (DFG Method S 9 and FDA multiresidue methods). In the FDA methods, thiamethoxam was not recovered from the cleanup columns. Stability of residues in stored analytical samples The meeting received information on the freezer storage stability of thiamethoxam and metabolite CGA 224 at residue concentrations in apples, tomatoes, potato tubers, rape seed, maize grain,

174 96 Thiamethoxam cranberries, hops, barley grain, barley hay, barley straw, pearled barley and barley flour. For the animal commodities, (beef, liver, milk and eggs), freezer storage stability data were available for thiamethoxam and two metabolites CGA 224 and CGA 265. Thiamethoxam, CGA 224 and CGA 265 were apparently stable at residue concentrations in the various substrates tested at the freezer temperatures and test durations. The durations of test were mostly 2 years, but some were less. Test temperatures were mostly approximately 8 C to 2 C, but other storage temperatures were used in some storage stability tests, e.g., between 26 C and 4 C. Residue definition In animal commodities, parent thiamethoxam was a major component of the residues in goat muscle, fat and kidney, while CGA 224 was the main component in milk, but thiamethoxam was also a substantial residue component in milk. In goat liver, thiamethoxam constituted only approximately % of the residues in goat liver with CGA 224 about 6 %. Some other metabolites were present at higher levels. In laying hens, parent thiamethoxam was not the major component of the residues in any tissue or eggs, but did constitute approximately 2% TRR in lean meat, 5 5% in fat + skin and % in egg yolk. Thiamethoxam was a very minor part of the residues in poultry liver, whereas CGA 224 constituted 4% and 9% of the liver TRR (8.2 and 9.2 mg/kg) in the poultry metabolism study with C labels in the thiazol and oxadiazin positions, respectively. Metabolite CGA 265 was the major residue component in the eggs, both whites (45% and 4%) and yolks (69% and 54%), and also in fat + skin (54% and 5%). Metabolite MU was the major residue component in lean hen meat. The complexity of the metabolite mixture makes it difficult to select an ideal residue definition for risk assessment in poultry. The Meeting decided to include CGA 265 and MU with thiamethoxam in the intake assessment of residues in poultry. Metabolite CGA 224 will be included in the clothianidin risk assessment. Because the dietary burden was low and no feeding study was available for poultry, data from the poultry metabolism studies were used in the risk assessment. For most purposes, thiamethoxam and CGA 224 are adequate for monitoring residues in animal commodities. In plant metabolism, parent thiamethoxam is usually an important component of the residues. Metabolite CGA 224 occurs in plant metabolism profiles above % TRR more commonly than do other plant metabolites. For plant commodities thiamethoxam and CGA 224 are the most important residues. Thiamethoxam is described as an EZ mixture. It is generally believed that the activation energy for the E Z interconversion for the C = bond is low and that an equilibrium mixture is rapidly established at ambient temperature. The situation is likely to be similar for metabolite CGA 224. In this case the E form is likely to be favoured in the equilibrium mixture because of possible formation of a hydrogen bond from the secondary amine to the nitro group. The E form of CGA 224 is equivalent to the compound clothianidin and with E Z interconversion, CGA 224 will appear the same as clothianidin in the analytical methods. Cl S CGA 224 CH H H O O Clothianidin residues may arise from the use of clothianidin or from the use of thiamethoxam. Separate residue definitions are needed: for thiamethoxam for clothianidin (from uses of clothianidin) and CGA 224 (from uses of thiamethoxam), appearing as clothianidin.

175 Thiamethoxam 96 The Meeting recommended the following residue definition for thiamethoxam. Definition of the residue for animal and plant commodities (for compliance with the MRL): thiamethoxam. Definition of the residue for plants and animals (except poultry), (for estimation of dietary intake): thiamethoxam CGA 224 (CGA 224 to be included with clothianidin and considered separately from thiamethoxam). See also clothianidin. Definition of the residue for poultry (for estimation of dietary intake): sum of thiamethoxam, CGA 265 and MU, expressed as thiamethoxam CGA 224 (CGA 224 to be included with clothianidin and considered separately from thiamethoxam). See also clothianidin. The residue is not fat soluble. ote that thiamethoxam metabolite CGA 224 (-(2-chlorothiazol-5-ylmethyl)-'-methyl- "-nitroguanidine) will appear as clothianidin in the analytical method and residues of CGA 224 occurring in food are included in the clothianidin MRLs. Metabolite CGA 265: -(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine. Metabolite MU: amino-([(2-chlorothiazol-5-ylmethyl)-amino]-methylene)-hydrazide. Residues resulting from supervised trials The Meeting received supervised field trials data for thiamethoxam uses on citrus, pome fruits, plums, peaches, cherries, strawberries, cranberries, blueberries, caneberries, grapes, bananas, mangoes, papaya, pineapples, broccoli, cabbage, mustard greens, cucumbers, melons, cantaloupes, summer squash, sweet corn, tomatoes, bell peppers, chilli peppers, egg plants, sweet peppers, lettuce, spinach, snap beans, lima beans, succulent peas, dry beans, peas (green pods), peas (dry seed), soya beans, carrots, radishes, potatoes, sugar beets, artichokes, celery, maize, barley, wheat, rice, pecan, sunflower, cotton, oilseed rape, cacao beans, coffee, pea forage and fodder, maize forage and fodder, barley straw and fodder, wheat straw and fodder, rice straw, beet leaves and tops, oilseed rape fodder and forage, hops and tea. For a specific crop, sets of trials were often available with different methods of application, e.g., foliar, soil treatment and seed treatment, and from different regions. The set of trials with an adequate number of trials and producing the highest residues was selected for maximum residue level estimation. The set of trials selected for thiamethoxam maximum residue level estimation was not necessarily the same set selected for metabolite CGA 224. The estimated maximum residue levels for CGA 224 are transferred to the clothianidin report for integration with the estimates for clothianidin. Citrus fruits Supervised trials data for citrus were available from Spain, Indonesia and the USA. Thiamethoxam may be used in Spain as a single foliar treatment of citrus with a WG formulation at a spray concentration of.5 kg ai/hl and harvest of fruit days later. In seven thiamethoxam trials on oranges in Spain in accord with Spanish GAP, thiamethoxam residue concentrations in whole oranges in rank order were:,.2,.,.5,.5,.6 and.6 mg/kg. Thiamethoxam residues in orange flesh were: (6) and.2 mg/kg. In one Spanish orange trial residues were at measurable levels in both flesh (.2 mg/kg) and fruit (.5 mg/kg) providing a factor of.4 to estimate thiamethoxam residues in edible portion from residues in whole fruit from foliar treatment. In the same seven orange trials from Spain, residues of CGA 224 in whole oranges as a metabolite of thiamethoxam were: (5),.2 and. mg/kg. CGA 224 residues in orange flesh were: () mg/kg.

176 962 Thiamethoxam In six thiamethoxam trials on lemons in Spain in accord with Spanish GAP, thiamethoxam residue concentrations in whole lemons in rank order were:.2,.4,.,.,.8 and.8 mg/kg. Thiamethoxam residues in lemon flesh were: (5) and.2 mg/kg. In the same six lemon trials from Spain, residues of CGA 224 in whole lemons were:,.2,.2,.2,. and.4 mg/kg. CGA 224 residues in lemon flesh were: (6) mg/kg. In eight thiamethoxam trials on mandarins in Spain in accord with Spanish GAP, thiamethoxam residue concentrations in whole mandarins in rank order were: (2),.2,.2,.,.4,. and. mg/kg. Thiamethoxam residues in mandarin flesh in nine trials were: (),.2 and.2 mg/kg. In the same eight mandarin trials from Spain, residues of CGA 224 in whole mandarins in rank order were: (),.2,.2,.2,. and.5 mg/kg (AFTA calculator:.5. OECD calculator Mean + 4SD:.68). CGA 224 residues in mandarin flesh in nine trials were: (8) and.2 mg/kg. This CGA 224 data set was selected for maximum residue level estimation. In Indonesia, thiamethoxam may be applied twice as foliar sprays on citrus with a ZC formulation at.85 kg ai/ha and harvest 42 days after the final application. In three trials on oranges in Indonesia in accord with Indonesian GAP, residues of thiamethoxam were :,. and.5 mg/kg. Residues of CGA 224 were not detected. Thiamethoxam may be used in the USA as a single soil treatment with SL formulations (chemigation in the root zone, drench around tree trunk and out to root zone or band each side of row) at.9 kg ai/ha. Thiamethoxam may also be used in two foliar applications with WG at.96 kg ai/ha during the production of citrus fruits. Fruit may be harvested on the same day as treatment. In 2 orange trials in the USA matching the soil surface application GAP, residues of thiamethoxam were all mg/kg. In the same trials, residues of CGA 224 in the oranges were also all mg/kg. In six grapefruit trials in the USA matching the soil surface application GAP, residues of thiamethoxam were all mg/kg. In the same trials, residues of CGA 224 in the grapefruits were also all mg/kg. In five lemon trials in the USA matching the soil surface application GAP, residues of thiamethoxam were all mg/kg. In the same trials, residues of CGA 224 in the lemons were also all mg/kg. In orange trials in the USA matching the US GAP for foliar application with a WG formulation, thiamethoxam residues, in rank order, were:.,.4,.6,.6,.6,.,.,.8,.2,.,.,.9,.2 and.26 mg/kg (AFTA calculator:.9. OECD calculator Mean + 4SD:.86). This data set was selected for maximum residue level estimation. In the same orange trials in the USA, residues of CGA 224 in rank order were: (8),.,.2,.2,.2,.2 and. mg/kg. In eight grapefruit trials in the USA matching US GAP for foliar application with a WG formulation, thiamethoxam residues, in rank order, were:.2,.,.4,.6,.6,.8,. and. mg/kg. In the same eight trials, residues of CGA 224 in rank order were: (6),. and. mg/kg. In six lemon trials in the USA matching US GAP for foliar application with a WG formulation, thiamethoxam residues, in rank order, were:.5,.6,.,.2,. and. mg/kg. In the same six trials, residues of CGA 224 in rank order were:,.,.,.2,.2 and.2 mg/kg. Summary Citrus fruits Residue data with suitable GAP were available for oranges, lemons, mandarins and grapefruit. The Meeting noted that thiamethoxam residues were highest in orange trials from the USA and that CGA 224 residues were highest in mandarin trials from Spain and decided to estimate citrus group maximum residue levels based on these data sets.

177 Thiamethoxam 96 On the basis of the foliar applications on oranges in the USA, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on citrus fruits. The STMR and HR for thiamethoxam in citrus were derived from the median and high residue of the US orange trials and a factor (residues in edible portion residues in =.4) from the Spanish trials. The Meeting estimated STMR and HR values of. and. mg/kg respectively for thiamethoxam residues in citrus fruits. On the basis of the CGA 224 data on mandarins from eight trials with foliar application of thiamethoxam in Spain, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 on citrus fruits. On the basis of the CGA 224 data on mandarin flesh from nine trials in Spain, the Meeting estimated STMR and HR values of.2 and.2 mg/kg respectively for CGA 224 residues in citrus fruits. Pome fruits Supervised trials data for pome fruits were available from the USA. US GAP for pome fruit allows the use of thiamethoxam for foliar application at.96 kg ai/ha with a 5 days PHI and.48 kg ai/ha with a days PHI. In 5 apple trials in the USA matching GAP for foliar application and the final rate suitable for a days PHI, thiamethoxam residues in rank order were:.,.4,.4,.5,.6,.6,.6,.,.8,.8,.9,.9,.,.2 and.5 mg/kg (AFTA calculator:.89. OECD calculator *Mean:.224). In the same 5 trials, residues of CGA 224 in apples in rank order were: (),. and.2 mg/kg. In six pear trials in the USA matching GAP for foliar application and the final rate suitable for a days PHI, thiamethoxam residues in rank order were:.,.,.4,.5,.5 and.8 mg/kg. In the same six trials, residues of CGA 224 in pears in rank order were:.,.2,.2,.,. and.4 mg/kg (AFTA calculator:.. OECD calculator *Mean:.5). Summary Pome fruits Residue data with suitable GAP were available for apples and pears from the USA. The Meeting noted that thiamethoxam residues were higher in the apple trials and that CGA 224 residues were higher in pears. The Meeting decided to estimate pome fruit group maximum residue levels based on these data sets. On the basis of the foliar applications on apples in the USA, the Meeting estimated a maximum residue level of. mg/kg for thiamethoxam on pome fruits. On the basis of the CGA 224 data on pears from the US trials, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 on pome fruits. The STMR and HR for thiamethoxam in pome fruits were derived from the median and high residues of the US apple trials. The Meeting estimated STMR and HR values of. and.5 mg/kg respectively for thiamethoxam residues in pome fruits. The STMR and HR for CGA 224 in pome fruits were derived from the median and high residues of the US thiamethoxam pear trials. The Meeting estimated STMR and HR values of.25 and.4 mg/kg respectively for CGA 224 residues in pome fruits. Stone fruits Supervised trials data were available for plums, peaches and cherries from the USA and cherries from France, Italy, Spain and Switzerland. o suitable GAP was available to evaluate the Swiss trials. US GAP for stone fruits allows the use of thiamethoxam for foliar application at.96 kg ai/ha with a days PHI.

178 964 Thiamethoxam In eight plum trials in the USA matching stone fruit GAP, thiamethoxam residues in plums in rank order were: (5),.,.2 and.2 mg/kg. In the same eight trials, residues of CGA 224 in plums in rank order were: (6),. and.2 mg/kg. In peach trials in the USA matching stone fruit GAP, thiamethoxam residues in peaches in rank order were:.,.2,.2,.2,.,.4,.4,.5,.5,.6 and.9 mg/kg. In the same peach trials, residues of CGA 224 in peaches in rank order were:.,.2,.2,.2,.2,.4,.4,.4,.4,.5 and.2 mg/kg (AFTA calculator:.4. OECD calculator Mean + 4SD:.58). This data set was selected for maximum residue level estimation. In cherry trials in the USA matching stone fruit GAP, thiamethoxam residues in cherries in rank order were:.,.,.9,.9,.2,.2,.22,.22,.24 and. mg/kg. In the same trials, residues of CGA 224 in cherries in rank order were:,,.,.,.,.2,.2,.,. and. mg/kg. Spanish GAP for cherries allows the use of thiamethoxam for two foliar applications with a spray concentration of.5 kg ai/hl followed by a days PHI. In 2 cherry trials in France (seven), Italy (three) and Spain (two) matching the Spanish GAP, thiamethoxam residues in cherries in rank order were:.,.5,.6,.6,.,.9,.2,.26,.,.49,.5 and.6 mg/kg (AFTA calculator:.82. OECD calculator Mean + 4SD:.92). This data set was selected for maximum residue level estimation. In the same 2 cherry trials, residues of CGA 224 in cherries in rank order were: (),.2,.2,.,.4 and.6 mg/kg. Summary Stone fruits Residue data with suitable GAP were available for plums, peaches and cherries. The Meeting noted that thiamethoxam residues were highest in cherry trials from Europe and that CGA 224 residues were highest in peach trials from the USA and decided to estimate stone fruits group maximum residue levels based on these two data sets. On the basis of the foliar applications on cherries in 2 trials in France, Italy and Spain, the Meeting estimated a maximum residue level of mg/kg for thiamethoxam on stone fruits. The Meeting estimated STMR and HR values of.95 and.6 mg/kg respectively for thiamethoxam residues in stone fruits. On the basis of the CGA 224 data on peaches from trials in the USA, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on stone fruits. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.4 and.2 mg/kg respectively for CGA 224 residues in stone fruits. Berries and other small fruits Supervised trials data were available for strawberries, cranberries, blueberries, caneberries and grapes. Cranberries Supervised trials data were available for cranberries from the USA. During the production of cranberries in the USA, thiamethoxam as a WG formulation may be used for foliar sprays at. kg ai/ha with observation of a days PHI. In six cranberry trials in the USA with a WG formulation and matching the conditions of the foliar treatment GAP, thiamethoxam residues in cranberries were all below LOQ (. mg/kg). In the same six trials, residues of CGA 224 in cranberries were also all below LOQ (. mg/kg). Blueberries Supervised trials data were available for blueberries from the USA.

179 Thiamethoxam 965 Thiamethoxam may be used as foliar applications (WG formulation) or a soil-applied surface band (SL formulation) during the production of blueberries in the USA. The application rate is. kg ai/ha in the foliar use (PHI days) or, for bushberries (includes blueberries),.2 kg ai/ha for the band application followed by a PHI of 5 days. In seven blueberry trials in the USA with an SL formulation and matching the conditions of the soil-applied surface band treatment GAP, thiamethoxam residues in blueberries were all below LOQ (. mg/kg). In the same seven trials, residues of CGA 224 in blueberries were also all below LOQ (. mg/kg). In nine blueberry trials in the USA with a WG formulation and matching the conditions of the foliar treatment GAP, thiamethoxam residues in blueberries in rank order were:,.5,.6,.6,.,.,.,. and. mg/kg. In the same nine trials, residues of CGA 224 in blueberries in rank order were: (4),.,.,.2,. and.5 mg/kg. This CGA 224 data set was used as part of the data for maximum residue level estimation for the berry fruits group. Blackberries, raspberries and boysenberries Supervised trials data were available from the USA for caneberries: raspberries (four trials), blackberries (one trial) and boysenberries (one trial). Thiamethoxam may be used as foliar applications (WG formulation) during the production of caneberries in the USA. The application rate is.5 kg ai/ha and the crop may be harvested days after an application. In six caneberry trials in the USA matching the conditions of the foliar treatment GAP, thiamethoxam residues in blackberries, raspberries and boysenberries in rank order were:.,.6,.,.2,.9 and.2 mg/kg. In the same six trials, residues of CGA 224 in blackberries, raspberries and boysenberries in rank order were:,.,.2,.2 and.4 mg/kg. This CGA 224 data set was used as part of the data for maximum residue level estimation for the berry fruits group. For CGA 224, the data from nine blueberry trials and six caneberry trials were combined to represent the group: (6),.,.,.,.2,.2,.2,.,.4 and.5 mg/kg (AFTA calculator:.56. OECD calculator Mean + 4SD:.69). Grapes Supervised trials data were available for grapes from France, Italy, Spain and Switzerland. In Spain and Italy, thiamethoxam formulated as WG is approved for foliar application to grapes at.5 kg ai/ha, with harvest permitted 2 days later. The trials from France, Italy and Spain were evaluated using the GAP from Spain and Italy. o suitable GAP was available for evaluation of the Swiss trials. In grape trials in Europe (seven French, one Italian and three Spanish) matching the conditions of the Spanish and Italian GAP, thiamethoxam residues in grapes in rank order were: (2),.2,.2,.2,.4,.4,.,.,. and.2 mg/kg (AFTA calculator:.26. OECD calculator Mean + 4SD:.45). In the same trials, residues of CGA 224 in grapes were: () and.2 mg/kg. On the basis of the foliar applications on grapes in European trials, the Meeting estimated a maximum residue level of.4 mg/kg for thiamethoxam in grapes. On the basis of the CGA 224 data on grapes from the same trials, the Meeting estimated a maximum residue level of.5 mg/kg for CGA 224 on grapes. The residue levels of thiamethoxam and CGA 224 occurring in grapes allow grapes to be included in the berry fruit group MRLs. Strawberries Supervised trials data were available for strawberries from the USA.

180 966 Thiamethoxam During the production of strawberries in the USA, thiamethoxam may be used as a single soil drench treatment (.2 kg ai/ha) with an SL formulation at the base of the plants followed by harvest 65 days later. Alternatively, a WG formulation may be used for foliar sprays at. kg ai/ha with observation of a days PHI. In eight strawberry trials in the USA with an SL formulation and matching the conditions of the drench treatment GAP, but with some flexibility in the PHI, thiamethoxam residues in strawberries in rank order were:,,.,.,.2,.2,. and. mg/kg. In the same eight trials, residues of CGA 224 in strawberries were all below LOQ (. mg/kg). In eight strawberry trials in the USA with a WG formulation and matching the conditions of the foliar treatment GAP, thiamethoxam residues in strawberries in rank order were:.2,.2,.5,.5,.6,.,.22 and.26 mg/kg (AFTA calculator:.8. OECD calculator Mean + 4SD:.46). This thiamethoxam data set was selected for maximum residue level estimation for the berry fruits group. In the same eight trials, residues of CGA 224 in strawberries were all below LOQ (. mg/kg). Summary Berries and other small fruits Residue data with suitable GAP were available for strawberries, cranberries, blueberries, caneberries and grapes. The Meeting noted that thiamethoxam residues were highest in strawberries and that CGA 224 residues were highest in blueberries and caneberries and decided to estimate berry fruit group maximum residue levels based on these two data sets. Grapes are often evaluated separately because the crop is rarely included in a berries crop group GAP and specific grape data are needed for its important processed commodities. However, the estimated maximum residue level for grapes closely agrees with that estimated for the other berry fruits, so the Meeting agreed to include the grapes with the berry fruits proposals. On the basis of the foliar applications on strawberries in eight US trials, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam in berries and other small fruits. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.55 and.26 mg/kg respectively for thiamethoxam residues in berries and other small fruits. On the basis of the nine blueberry trials and six caneberry trials from the USA, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 in berries and other small fruits. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of. and.5 mg/kg respectively for CGA 224 residues in berries and other small fruits. Assorted tropical and sub-tropical fruits inedible peel Supervised trials data were available for bananas, mangoes, papaya and pineapples. Bananas Supervised trials data were available for bananas from Cameroon. In Cameroon, thiamethoxam WG is approved for use as a drench to the banana stem at a concentration of.2 kg ai/hl and application volume ml per plant, equivalent to.2 g ai per plant, with harvest permitted on the same day. In three banana trials with thiamethoxam in Cameroon at the approved application rate and one at double rate and with bananas harvested 6 days after treatment, thiamethoxam residues in bananas were all below LOQ (.2 mg/kg). In a further trial at the label rate, banana pulp was analysed but again thiamethoxam residues were below LOQ (.2 mg/kg). In all these samples, CGA 224 residues also were all below LOQ (.2 mg/kg).

181 Thiamethoxam 96 The Meeting estimated a maximum residue level of.2* mg/kg for thiamethoxam in bananas. On the basis of the CGA 224 data on bananas from the same 2 trials, the Meeting estimated a maximum residue level of.2* mg/kg for CGA 224 on bananas. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.2 and.2 mg/kg for thiamethoxam residues in bananas. The Meeting also estimated STMR and HR values of.2 and.2 mg/kg for CGA 224 residues in bananas. Mangoes Supervised trials data were available for mangoes from South Africa. In South Africa, thiamethoxam is approved for application to mango trees as a drench around the trees or by drip irrigation at a dose of.4 g ai per tree. The timing of the application is set by a seasonal instruction: apply from last week in July to mid August. The harvesting season for mangoes would follow in early to mid-summer. One of the trials was compromised of residues of thiamethoxam (.2 mg/kg) and CGA 224 (.2 mg/kg) appearing in samples from the control plot at similar levels to those from treated plots. Three of the mango trials followed the label rate for application:.4 g ai per tree, resulting in thiamethoxam residues in mangoes,.4,. and. mg/kg. The same three trials produced CGA 224 residues in mangoes of,.2 and.2 mg/kg. Three trials for mangoes are insufficient to support a maximum residue level. Papaya Supervised trials data were available for papaya from Brazil and Côte d'ivoire. o GAP was available to evaluate the Côte d'ivoire trials. In Brazil, thiamethoxam is approved as a soil drench application for papaya at a rate equivalent to.2 kg ai/ha. A PHI of days is specified. Four of the papaya trials in Brazil followed the label rate of application,.2 kg ai/ha with thiamethoxam residues in papaya fruits all below LOQ (. mg/kg). The same four trials produced CGA 224 residues in papaya fruits also all below LOQ (. mg/kg). Four of the papaya trials in Brazil followed a double rate of application,.4 kg ai/ha with the same results as the label rate, thiamethoxam residues in papaya fruits all below LOQ (. mg/kg). The same four trials produced CGA 224 residues in papaya fruits also all below LOQ (. mg/kg). The Meeting estimated a maximum residue level of.* mg/kg for thiamethoxam in papaya. On the basis of the CGA 224 data on papaya from the same trials, the Meeting estimated a maximum residue level of.* mg/kg for CGA 224 on papaya. The Meeting estimated STMR and HR values of and mg/kg for thiamethoxam residues in papayas. The Meeting also estimated STMR and HR values of and mg/kg for CGA 224 residues in papayas. Pineapples Supervised trials data were available for pineapples from Brazil. In Brazil, thiamethoxam is approved for pineapples as a pre-seedling transplant immersion in a solution concentration.5 kg ai/hl, and as a soil drench at the plant base 45 6 days after transplant at an application rate of.2 kg ai/ha. In the Brazilian trials, this seedling treatment and soil drench usage GAP was followed, but another thiamethoxam soil drench was added 6 days before harvest. In the four trials,

182 968 Thiamethoxam thiamethoxam residues in pineapples were all below LOQ (. mg/kg). Residues of CGA 224 were also all below LOQ (. mg/kg). The Meeting estimated a maximum residue level of.* mg/kg for thiamethoxam in pineapples. On the basis of the CGA 224 data on pineapples from the same trials, the Meeting estimated a maximum residue level of.* mg/kg for CGA 224 on pineapples. The Meeting estimated STMR and HR values of and mg/kg for thiamethoxam residues in pineapples. The Meeting also estimated STMR and HR values of and mg/kg for CGA 224 residues in pineapples. Brassica vegetables Supervised trials data were available for cabbages and broccoli. Cabbages Supervised trials data on cabbage were available from the USA. In the USA, foliar applications of thiamethoxam may be made to head and stem Brassica vegetables (includes cabbage) at.96 kg ai/ha, with harvest on the same day. Soil drench applications of thiamethoxam to Brassica vegetables at.9 kg ai/ha with a days PHI are also registered. The soil drench rate in the cabbage trials was. kg ai/ha and the data were not evaluated. In eight cabbage trials in the USA matching the foliar GAP conditions, thiamethoxam residues in cabbages (with wrapper leaves) in rank order were:.5,.59,.62,.69,.8,.9,. and. mg/kg. In the same eight trials, residues of CGA 224 in cabbages (with wrapper leaves) in rank order were:.2,.2,.,.,.4,.5,.6 and.8 mg/kg. In the same eight cabbage trials, residues were also measured on cabbage heads only, i.e., with wrapper leaves removed. Thiamethoxam residues in cabbage heads in rank order were:.,.2,.,.5,.5,.9,. and. mg/kg. In the same eight trials, residues of CGA 224 in cabbage heads were: () and. mg/kg. Two of the cabbage trials matching the foliar GAP conditions were side-by-side trials providing bridging data for the use of WG and SL formulations. Thiamethoxam residues in the head + wrapper leaves were.5 and.5 mg/kg for SL and.69 and.58 mg/kg for WG, and for head only the residues were and. mg/kg for SL and.5 and.2 mg/kg for WG. CGA 224 residues in the head + wrapper leaves were and.4 mg/kg for SL and.4 and.5 mg/kg for WG. The results suggest equivalence, so only one of the bridging trials should be included in the dataset for STMR and maximum residue level estimation. The cabbage datasets become: Thiamethoxam head + wrapper leaves (n = ):.59,.62,.69,.8,.9,. and. mg/kg. (AFTA calculator:.6. OECD calculator Mean + 4SD:4.5 ) CGA 224 head + wrapper leaves (n = ):.2,.2,.,.,.5,.6 and.8 mg/kg. (AFTA calculator:.29. OECD calculator Mean + 4SD:.2) thiamethoxam head only (n = ):.2,.,.5,.5,.9,. and. mg/kg CGA 224 head only (n = ): (6) and. mg/kg. Broccoli Supervised trials data on broccoli were available from the USA. In the USA, foliar applications of thiamethoxam may be made to head and stem Brassica vegetables (includes broccoli) at.96 kg ai/ha, with harvest on the same day.

183 Thiamethoxam 969 In broccoli trials in the USA matching the GAP conditions, thiamethoxam residues in broccoli in rank order were:.,.,.4,.,.4,.49,.5,.66,. and. mg/kg. In the same trials, residues of CGA 224 in broccoli in rank order were: (4),.,.2,.,.4,.4 and.4 mg/kg. Four of the broccoli trials matching the foliar GAP conditions were side-by-side trials providing bridging data for the use of WG and SL formulations. In one pair of trials, from California, thiamethoxam residues in the head + stem were.4 and. g/kg for SL and.49 and.44 mg/kg for WG. CGA 224 residues were. and. mg/kg for SL and.2 and.2 mg/kg for WG. In the second pair of trials, from Texas, thiamethoxam residues in the head + stem were.8 and.4 g/kg for SL and.2 and.4 mg/kg for WG. CGA 224 residues were.2 and.4 mg/kg for SL and. and.2 mg/kg for WG. The results suggest equivalence, so only one from each pair of the bridging trials should be included in the dataset for STMR and maximum residue level estimation. The broccoli datasets (n = 8) become: thiamethoxam.,.,.4,.49,.5,.66,. and. mg/kg CGA 224 (4),.2,.4,.4 and.4 mg/kg. These data sets were selected for the STMR and HR estimation for the Brassica group. Summary Brassica vegetables group Residue data with suitable GAP were available for broccoli and cabbages. The Meeting noted that residues in cabbage with wrapper leaves had higher residues than the broccoli and decided to use the cabbage data to support Brassica group MRLs. On the basis of the foliar applications on cabbages in the US trials, the Meeting estimated a maximum residue level of 5 mg/kg for thiamethoxam on Brassica vegetables. On the basis of the CGA 224 data on cabbages from the same trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on Brassica vegetables. The Meeting noted that residues in broccoli had higher residues than the cabbages (heads only) and decided to use the broccoli data to support Brassica group STMRs and HRs. On the basis of the foliar applications on broccoli in the eight US trials, the Meeting estimated an STMR and an HR value of.5 and. mg/kg respectively for thiamethoxam on Brassica vegetables. On the basis of the CGA 224 data on broccoli from the same trials, the Meeting estimated an STMR and an HR value of.5 and.4 mg/kg respectively for CGA 224 on Brassica vegetables. For livestock dietary burden, it is more appropriate to include the cabbage wrapper leaves in the STMR and high residue estimates. In this case the STMR and high residue values for thiamethoxam on cabbages are.8 and. mg/kg respectively. For CGA 224, the STMR and high residue values on cabbage are. and.8 mg/kg respectively. Fruiting vegetables, Cucurbits Supervised trials data were available for cucumbers, melons and cantaloupes and summer squash. Cucumbers Supervised trials data on cucumbers were available from France, etherlands, Spain and the USA. In the USA, foliar applications of thiamethoxam may be made to cucurbit vegetables (includes cucumbers) at.96 kg ai/ha, with harvest on the same day. In-furrow spray or soil surface band applications of thiamethoxam to cucurbit vegetables at.9 kg ai/ha with a days PHI are also registered in the USA. The in-furrow and surface band treatment rate in the cucumber trials was. kg ai/ha and the data could not be evaluated.

184 9 Thiamethoxam In eight cucumber trials in the USA matching the foliar GAP conditions, thiamethoxam residues in cucumbers in rank order were:.2,.4,.5,.,.,.8,.9 and. mg/kg. In the same eight trials, residues of CGA 224 in cucumbers were all below LOQ mg/kg). In Italy, thiamethoxam may be applied to cucumbers by drip or drench at.2 kg ai/ha, with harvest permitted days later. Drip refers to application to the base of each plant through the drip application system. Drench is application by watering soil around plants. The protected cucumber trials in France, etherlands and Spain relied on drip, drench and syringe applications. A syringe may be used in an experimental situation to simulate drip application. In six cucumber trials in France, etherlands and Spain following Italian GAP, thiamethoxam residues in cucumbers in rank order were:.6,.6,.9,.2,. and.29 mg/kg (AFTA calculator:.42. OECD calculator Mean + 4SD:.4). The Meeting noted that application at. kg ai/ha (½ label rate) produced residues of. and.2 mg/kg. In the same six trials, residues of CGA 224 in cucumbers were all below LOQ mg/kg). These data sets for both thiamethoxam and CGA 224 were selected for estimation of maximum residue levels for cucurbit fruiting vegetables. Melons and cantaloupes Supervised trials data on melons and cantaloupes were available from Italy, Spain and the USA. Thiamethoxam is approved for use on melons in Spain as a drip irrigation method of application:.2 kg ai/ha for indoor production and. kg ai/ha for outdoor production. A PHI of days is specified. The two trials from Italy could not be evaluated because no suitable GAP was available. In four melon trials in Spain matching the drip irrigation GAP conditions (but with allowances on the PHI), thiamethoxam residues in cucumbers in rank order were:,.2,.2 and. mg/kg. In the same four trials, residues of CGA 224 in melons were all below LOQ mg/kg). In the USA, foliar applications of thiamethoxam may be made to cucurbit vegetables (includes cantaloupes) at.96 kg ai/ha, with harvest on the same day. In-furrow spray applications of thiamethoxam to cucurbit vegetables at.9 kg ai/ha with a days PHI are also registered in the USA. The in-furrow treatment rate in the cantaloupe trials was. kg ai/ha and the data could not be evaluated. In six cantaloupe trials in the USA matching the foliar application GAP conditions, thiamethoxam residues in cantaloupes in rank order were:.,.,.4,.,. and.6 mg/kg. In the same six trials, residues of CGA 224 in cantaloupes were all below LOQ (. mg/kg). Summer squash Supervised trials data for thiamethoxam use on summer squash were available from the USA. In the USA, foliar applications of thiamethoxam as a WG may be made to cucurbit vegetables (includes summer squash) at.96 kg ai/ha, with harvest on the same day. In five summer squash trials in the USA matching the foliar application GAP conditions, thiamethoxam residues in summer squash in rank order were:.2,.5,.6,. and.6 mg/kg. In the same five trials, residues of CGA 224 in summer squash in rank order were all below LOQ (. mg/kg). Summary Fruiting vegetables, Cucurbits Residue data with suitable GAP were available for cucumbers, melons and cantaloupes and summer squash. The Meeting noted that thiamethoxam residues were highest in cucumbers and that CGA 224 residues were below LOQ in cucurbit fruiting vegetables. The Meeting decided to estimate cucurbit fruiting vegetables group maximum residue levels based on the cucumber data sets.

185 Thiamethoxam 9 On the basis of the drip, drench and syringe applications on cucumbers in six European trials, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on cucurbit fruiting vegetables. On the basis of the CGA 224 data on cucumbers from the same six trials, the Meeting estimated a maximum residue level of.2* mg/kg for CGA 224 on cucurbit fruiting vegetables. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.5 and.29 mg/kg respectively for thiamethoxam residues in cucurbit fruiting vegetables. The Meeting estimated STMR and HR values of.2 and.2 mg/kg for CGA 224 residues in cucurbit fruiting vegetables. Fruiting vegetables, other than Cucurbits Supervised trials data were available for sweet corn, tomatoes, peppers, egg plants and okra. Egg plant Supervised trials data for thiamethoxam use on egg plants were available from Switzerland and the UK. Thiamethoxam is approved in Italy for foliar application on egg plants at. kg ai/ha, two applications at an interval of days, with harvest days after application. In one greenhouse egg plant trial in the UK matching Italian GAP, thiamethoxam residues in egg plant were.2 mg/kg with CGA 224 residues mg/kg. Sweet corn Supervised trials data for thiamethoxam use on sweet corn were available from the USA. In the USA, thiamethoxam is formulated as an FS seed treatment that may be used on sweet corn at.25 mg ai per kernel. This is equivalent to approx 4.5 g ai/kg seed for a single kernel weight of. g. In 2 sweet corn trials in the USA where the seed had been treated with thiamethoxam FS at 4.5 g ai/kg seed, thiamethoxam residues and CGA 224 residues in the harvested sweet corn ears were all below LOQ (. mg/kg). The Meeting estimated a maximum residue level and STMR and HR values, all at. mg/kg for thiamethoxam in sweet corn (corn-on-the-cob). The Meeting estimated a maximum residue level and STMR and HR values, all at. mg/kg for CGA 224 in sweet corn (corn-on-the-cob). Peppers Supervised trials data for thiamethoxam use on bell peppers and chilli peppers were available from the USA and on sweet peppers from France, Italy, Spain, Switzerland and the UK. o suitable GAP was available to evaluate the data from Switzerland and the UK. Thiamethoxam is approved in Italy for foliar application on peppers at. kg ai/ha, with harvest days after application. In eight sweet pepper field trials in Italy and Spain matching the Italian GAP conditions for peppers, thiamethoxam residues in sweet peppers in rank order were:.,.,.6,.8,.8,.9,. and.24 mg/kg. In the same eight trials, residues of CGA 224 in sweet peppers were all below LOQ (.2 mg/kg). In sweet pepper greenhouse trials in France, Italy, Spain, Switzerland and the UK matching the Italian GAP conditions for peppers, thiamethoxam residues in sweet peppers in rank order were:.,.,.8,.8,.8,.8,.,.2,.6,.26 and.4 mg/kg (AFTA calculator:.5. OECD calculator Mean + 4SD:.62). In the same trials, residues of CGA 224 in sweet

186 92 Thiamethoxam peppers were: (9),.2 and. mg/kg. These data sets were selected for maximum residue level estimations for the fruiting vegetables group, except sweet corn. In the USA, foliar applications of thiamethoxam as a WG may be made to fruiting vegetables (includes peppers) at.96 kg ai/ha, with harvest on the same day. In six bell pepper trials in the USA matching the foliar GAP conditions for fruiting vegetables, thiamethoxam residues in sweet peppers in rank order were:.,.6,.8,.,. and.8 mg/kg. In the same six trials, residues of CGA 224 in sweet peppers were: (5) and. mg/kg. In three chilli pepper trials in the USA matching the foliar GAP conditions for fruiting vegetables, thiamethoxam residues in chilli peppers in rank order were:.6,. and.22 mg/kg. In the same three trials, residues of CGA 224 in chilli peppers were: and.6 mg/kg. Okra Supervised trials data for thiamethoxam use on okra were available from Côte d'ivoire. In Kenya, foliar applications of thiamethoxam as a WG may be made to okra at. kg ai/ha, with harvest days later. The Meeting agreed to evaluate the data from Côte d'ivoire with the Kenyan GAP, allowing that the 2 days PHI in the trials was sufficiently close to the days PHI specified in the Kenyan GAP. In four okra trials in Côte d'ivoire at an application rate of. kg ai/ha and a PHI of days, reported thiamethoxam residues in okra in rank order were:.,.,. and.24 mg/kg. The analytical method used for thiamethoxam residue analysis was an imidacloprid residue analytical method, presumably adapted to thiamethoxam. o validation data were available, but procedural recoveries of 8% and % were recorded. Metabolite CGA 224 residues were not included in the analyses and the reported residues of thiamethoxam include only parent thiamethoxam. Tomatoes Supervised trials data for thiamethoxam use on tomatoes were available from France, Italy, Spain, Switzerland and the USA. o suitable GAP was available to evaluate the Swiss trials. Thiamethoxam is approved for foliar application on tomatoes in Italy at. kg ai/ha, with harvest days after application. In tomato field trials in France, Italy and Spain in accord with the GAP conditions of Italy, thiamethoxam residues in tomatoes in rank order were: (),.2,.2,.2,.2,.2,.,.,.,.4 and.4 mg/kg. In the same trials, residues of CGA 224 in tomatoes were: (6) and. mg/kg. In tomato greenhouse trials in France, Italy, Spain and Switzerland in accord with the GAP conditions of Italy, thiamethoxam residues in tomatoes in rank order were:.2,.2,.2,.,.,.,.,.6,. and.2 mg/kg. In the same trials, residues of CGA 224 in tomatoes were all below LOQ (.2 mg/kg). In the USA, foliar applications of thiamethoxam as a WG may be made to fruiting vegetables (includes tomatoes) at.96 kg ai/ha, with harvest on the same day. In 2 tomato trials in the USA matching the foliar GAP conditions, thiamethoxam residues in tomatoes in rank order were:.2,.,.,.4,.4,.5,.5,.6,.6,.6,.6,.,.,.,.8,.,.,.2,. and.5 mg/kg. In the same 2 trials, residues of CGA 224 in tomatoes in rank order were: (9),.,.,.,.2,.2,.2,.2,.,.,.4 and.5 mg/kg. Four of the tomato trials matching the foliar GAP conditions were side-by-side trials providing bridging data for the use of WG and SL formulations. In one pair of trials, from California, thiamethoxam residues in the tomatoes were. and. g/kg for SL and.6 and.2 mg/kg for WG. CGA 224 residues were and.2 mg/kg for SL and and. mg/kg for WG. In

187 Thiamethoxam 9 the second pair of trials, from Florida, thiamethoxam residues in the tomatoes were. and.8 g/kg for SL and.5 and.6 mg/kg for WG. CGA 224 residues were for both SL and WG. The results suggest equivalence, so only one from each pair of the bridging trials should be included in the dataset for STMR and maximum residue levels estimation. The tomato datasets become (n = 8): thiamethoxam.2,.,.,.4,.4,.5,.5,.6,.6,.,.,.,.8,.,.,.2,. and.5 mg/kg; CGA 224 (8),.,.,.2,.2,.2,.2,.,.,.4 and.5 mg/kg. Summary Fruiting vegetables, other than Cucurbits Residue data with suitable GAP were available for sweet corn, tomatoes, peppers, egg plants and okra. The Meeting noted that thiamethoxam residues and CGA 224 were highest in peppers and decided to estimate fruiting vegetable group maximum residue levels based on the peppers data sets. Residues in sweet corn appeared inconsistent with residues from other members of the commodity group, so the Meeting agreed on separate MRLs for sweet corn. Mushrooms were also excluded from the group MRLs. On the basis of the foliar applications on sweet peppers in greenhouse trials in France, Italy, Spain, Switzerland and the UK the Meeting estimated a maximum residue level of. mg/kg for thiamethoxam in fruiting vegetables other than cucurbits, except sweet corn. On the basis of the CGA 224 data on sweet peppers from the same trials, the Meeting estimated a maximum residue level of.5 mg/kg for CGA 224 in fruiting vegetables other than cucurbits, except sweet corn and mushrooms. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.8 and.4 mg/kg respectively for thiamethoxam residues in fruiting vegetables other than cucurbits, except sweet corn and mushrooms. The Meeting estimated STMR and HR values of.2 and. mg/kg for CGA 224 residues in fruiting vegetables other than cucurbits, except sweet corn and mushrooms. The JMPR Manual (Section 6.9.2) explains that a generic factor may be used for conversion of residues from fresh peppers to dried chilli peppers. The factor is for the estimation of residue levels of pesticides in dried chilli peppers from the HR values estimated for residues in or on sweet peppers. The Meeting agreed to apply the default factor of for dried chilli peppers to the STMR (.8 mg/kg) and HR (.4 mg/kg) values for thiamethoxam in fruiting vegetables other than cucurbits (based on sweet pepper data) and estimated a maximum residue level, an STMR and an HR for thiamethoxam in dried chilli peppers of,.8 and 4. mg/kg, respectively. For CGA 224, the Meeting also agreed to apply the default factor of for dried chilli peppers to the STMR (.2 mg/kg) and HR (. mg/kg) values based on sweet peppers and estimated a maximum residue level, an STMR and an HR for CGA 224 in dried chilli peppers of.5,.2 and. mg/kg, respectively. Leafy vegetables Supervised trials data were available for lettuce, spinach and mustard greens. Lettuce Supervised trials data for thiamethoxam use on lettuce were available from the USA. In the USA, foliar applications of thiamethoxam as a WG may be made to leafy vegetables (includes lettuce) at.96 kg ai/ha, with harvest days after treatment. Thiamethoxam may also be used as a soil treatment at planting (in-furrow spray, surface band or drench) for leafy vegetables at.9 kg ai/ha with an expected time to harvest of 65 days. A shanked into root zone after transplanting application at.9 kg ai/ha, with a 5 days PHI is also available.

188 94 Thiamethoxam In eight head lettuce trials in the USA matching the foliar GAP conditions, thiamethoxam residues in head lettuces in rank order were:.2,.4,.,.2,.2,.24,.25 and.45 mg/kg. In the same eight trials, residues of CGA 224 in head lettuces in rank order were: (4),.,.,. and. mg/kg. In leaf lettuce trials in the USA matching the foliar GAP conditions, thiamethoxam residues in leaf lettuces in rank order were:.,.,.22,.25,.5,.55,.86,.88,. and.9 mg/kg (AFTA calculator:.442. OECD calculator Mean + 4SD: 2.9). This data set was selected for a thiamethoxam maximum residue level estimation for the leafy vegetables commodity group. In the same trials, residues of CGA 224 in leaf lettuces in rank order were:,.,.,.,.,.,.4,.4,.4 and. mg/kg. In six leaf lettuce trials in the USA matching the soil treatment GAP conditions, thiamethoxam residues in leaf lettuces in rank order were:.,.5,.2,.6,.55 and.85 mg/kg. In the same six trials, residues of CGA 224 in leaf lettuces in rank order were:,.,.,.5 and. mg/kg. Spinach Supervised trials data for thiamethoxam use on spinach were available from the USA. In the USA, foliar applications of thiamethoxam as a WG may be made to leafy vegetables (includes spinach) at.96 kg ai/ha, with harvest days after treatment. In spinach trials in the USA matching the foliar GAP conditions for leafy vegetables, thiamethoxam residues in spinach in rank order were:.2,.2,.5,.,.22,.,.,.,.62 and.66 mg/kg. In the same trials, residues of CGA 224 in spinach in rank order were:.,.,.2,.9,.49,.54,.6,.62,. and.8 mg/kg (AFTA calculator: 2.5. OECD calculator Mean + 4SD:.45). This data set was selected for a CGA 224 maximum residue level estimation for the leafy vegetables commodity group. Mustard greens Supervised trials data on mustard greens were available from the USA. In the USA, foliar applications of thiamethoxam may be made to leafy greens Brassica vegetables (includes mustard greens) at.96 kg ai/ha, with harvest days after an application. In-furrow spray or soil surface band applications of thiamethoxam to Brassica vegetables at.9 kg ai/ha with a days PHI are also registered uses. The in-furrow and surface band treatments rate in the mustard greens trials was. kg ai/ha and the data could not be evaluated. In six mustard greens trials in the USA matching the foliar GAP conditions, thiamethoxam residues in mustard greens in rank order were:.8,.42,.42,.66,.69 and.5 mg/kg. In the same six trials, residues of CGA 224 in mustard greens in rank order were:.,.8,.2,.6,.2 and.29 mg/kg. Two of the mustard greens trials matching the foliar GAP conditions were side-by-side trials providing bridging data for the use of WG and SL formulations. Thiamethoxam residues in the leaves were.69 and.6 mg/kg for SL and.69 and.5 mg/kg for WG. CGA 224 residues in the leaves were.2 and. mg/kg for SL and.8 and.2 mg/kg for WG. The results suggest equivalence, so only one of the bridging trials should be included in the dataset for STMR and maximum residue level estimation. The mustard green datasets become (n = 5): thiamethoxam 8,.42,.42,.66, and.5 mg/kg; CGA 224.,.8,.6,.2 and.29 mg/kg.

189 Thiamethoxam 95 Summary Leafy vegetables Residue data with suitable GAP were available for leaf lettuce, head lettuce, spinach and mustard greens. The Meeting noted that thiamethoxam residues were highest in leaf lettuce and that CGA 224 residues were highest in spinach and decided to estimate leafy vegetables group maximum residue levels based on these two data sets. On the basis of the foliar applications on leaf lettuces in US trials, the Meeting estimated a maximum residue level of mg/kg for thiamethoxam on leafy vegetables. The STMR and HR values were.54 and.9 mg/kg, respectively. On the basis of the foliar applications on spinach in US trials, the Meeting estimated a maximum residue level of 2 mg/kg for CGA 224 on leafy vegetables. The STMR and HR values were.52 and.8 mg/kg, respectively. Legume vegetables Supervised trials data were available for beans and peas. Beans Supervised trials data for thiamethoxam seed treatment uses on beans were available from the USA. In the USA, thiamethoxam is registered for use as an FS formulation on bean seed at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In seven snap bean trials in the US with seeds treated at the label rate (.5 g ai/kg seed) and in seven trials where seeds were treated at the label rate, residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested snap beans (include succulent seeds and pods). In six lima bean trials in the US with seeds treated at the label rate (.5 g ai/kg seed) and in six trials where seeds were treated at the label rate, residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested lima beans (include succulent seeds, pods are discarded). Peas Supervised trials data for thiamethoxam seed treatment uses on peas were available from the USA. In the USA, thiamethoxam is registered for use as an FS formulation on pea seeds at 25 g ai per kg seed, i.e.,.25 g ai/kg seed. In seven pea trials in the US with seeds treated at 2 the label rate (.5 g ai/kg seed) and in seven trials where seeds were treated at 6 the label rate, residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested succulent shelled peas (include succulent seeds, pods are discarded), except for two trials at 6 where a thiamethoxam residue of. mg/kg was recorded. In three pea trials in the US with seeds treated at the 2 the label rate (.5 g ai/kg seed) and in three trials where seeds were treated at 6 the label rate, residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested succulent edible pods (include succulent seeds and pods), except for one trial at 6 where a thiamethoxam residue of. mg/kg was recorded. Summary Legume vegetables Residue data with suitable GAP were available for snap beans, lima beans, succulent shelled peas and succulent seeds and pods. Residues were below LOQ. The Meeting decided to estimate legume vegetables group maximum residue levels. On the basis of the seed treatment trials on peas and beans, the Meeting estimated a maximum residue level of.* mg/kg for thiamethoxam on legume vegetables. On the basis of the

190 96 Thiamethoxam CGA 224 data from the same trials, the Meeting also estimated a maximum residue level of.* mg/kg for CGA 224 on legume vegetables. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of. and. mg/kg for thiamethoxam residues in legume vegetables. The Meeting also estimated STMR and HR values of. and. mg/kg for CGA 224 residues in legume vegetables. Pulses Supervised trials data were available for beans, peas and soya beans. Beans, dry Supervised trials data for thiamethoxam seed treatment uses on beans were available from the USA. In the USA, thiamethoxam is registered for use as an FS formulation on bean seed at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In nine bean trials in the US with seeds treated at the label rate (.5 g ai/kg seed) and in nine trials where seeds were treated at the label rate, residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested dry beans. Peas, dry Supervised trials data for thiamethoxam seed treatment uses on peas producing dry peas were available from the USA, Denmark, France and Germany. In the USA, thiamethoxam is registered for use as an FS formulation on pea seed at 25 g ai per kg seed, i.e.,.25 g ai/kg seed. In five pea trials in the US with seeds treated at 2 the label rate (.5 g ai/kg seed), residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested dry peas. In five pea trials in the US with seeds treated at 6 the label rate (.4 g ai/kg seed), residues of thiamethoxam did not exceed the LOQ (. mg/kg) in the harvested dry peas. CGA 224 residues were: (),.2 and.2 mg/kg. In the Czech Republic, thiamethoxam is registered for use as an FS formulation on pea seed at 5 g ai per kg seed (.5 g ai/kg seed). In 2 pea trials in Europe (Denmark two, France and Germany four) with seeds treated with thiamethoxam at.5 g ai/kg seed (Czech Republic GAP), residues of thiamethoxam in the harvested dry peas at maturity were: (8),.2 and <.5 mg/kg. In the same 2 trials, residues of CGA 224 were all below LOQ (.2 (9) and <.5 mg/kg). The Meeting recognized that residues of thiamethoxam and metabolite CGA 224 from seed treatment uses were mostly below LOQ, but could sometimes occur in the dry peas. Soya beans Supervised trials data for thiamethoxam seed treatment uses on soya beans were available from the USA. In the USA, thiamethoxam is registered for use as an FS formulation on soya bean seeds at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In 5 soya bean trials in the US with seeds treated at the label rate (.5 g ai/kg seed), residues of thiamethoxam and CGA 224 did not exceed the LOQ (. mg/kg) in the harvested soya bean dry seed.

191 Thiamethoxam 9 Summary Pulses Residue data with suitable GAP were available for dry beans, dry peas and soya beans. Residues were almost all below LOQ. The Meeting decided to estimate pulse group maximum residue levels. On the basis of the 2 seed treatment trials on peas in Europe, the Meeting estimated a maximum residue level of.4 mg/kg for thiamethoxam on pulses. On the basis of the CGA 224 data from the same trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on pulses. The same data were used for STMR estimates. The Meeting estimated an STMR value of.2 mg/kg for thiamethoxam residues in pulses. The Meeting also estimated an STMR value of.2 mg/kg for CGA 224 residues in pulses. Root and tuber vegetables Supervised trials data were available for carrots, potatoes, radishes and sugar beets. Carrots Supervised trials data for thiamethoxam uses on carrots were available from the USA. In the USA, thiamethoxam may be used in foliar applications to root vegetables (includes carrot) at. kg ai/ha, with harvest permitted days after an application. Thiamethoxam may also be used as a soil surface band with incorporation after sowing or in-furrow spray treatments with an application rate of.2 kg ai/ha for root vegetables. In eight carrot trials in the USA matching the foliar GAP conditions, thiamethoxam residues in carrots did not exceed the LOQ (. mg/kg). In the same eight trials, residues of CGA 224 in carrots also in did not exceed the LOQ (. mg/kg). In six carrot trials in the USA matching the soil surface band GAP conditions, thiamethoxam residues in carrots in rank order were:,.,.2,.2 and.4 mg/kg. In the same six trials, residues of CGA 224 in carrots did not exceed the LOQ (. mg/kg). Potatoes Supervised trials data for thiamethoxam uses on potatoes were available from France, Germany, Spain, Switzerland, the UK and the USA. In Spain, foliar applications of thiamethoxam may be made to potatoes at.25 kg ai/ha, with harvest days after an application. In Hungary, foliar applications of thiamethoxam may be made to potatoes at.2 kg ai/ha, with harvest days after an application. These two use patterns are very similar and were used to evaluate the trials from France, Germany, Spain, Switzerland and the UK. In potato trials in Europe (France four, Germany two, Spain four, Switzerland two and the UK one) with foliar application of thiamethoxam at.25 kg ai/ha and harvest of tubers days later, residues of thiamethoxam and CGA 224 did not exceed the LOQs ( mg/kg) in any tuber sample. In the USA, thiamethoxam is registered for foliar application to tuberous and corm vegetables (includes potato) at.5 kg ai/ha, with harvest permitted days after an application. Also, potato seed pieces may be treated with thiamethoxam FS at g ai per kg seed. In potato trials in the USA with foliar application of thiamethoxam at approx 2 the label rate (.99 kg ai/ha) and harvest of tubers days later, residues of thiamethoxam and CGA 224 did not exceed the LOQs ( mg/kg) in any tuber sample. In 6 potato trials in the USA with potato seed pieces treated with thiamethoxam FS and DS at 8 g ai per kg seed pieces, the residues of thiamethoxam in harvested mature tubers were: (),.2,.5,.,.8 and.2 mg/kg (AFTA calculator:.242. OECD calculator Mean + 4SD:.8). In the same 6 trials, residues of CGA 224 in the harvested tubers were: (2),.4,

192 98 Thiamethoxam.4,.6 and.5 mg/kg (AFTA calculator:.5. OECD calculator Mean+4SD:.2). ote that the nominal 8 g ai per kg seed pieces in these trials is % higher than the label maximum rate 6.2 g ai per kg seed. These data sets were selected for maximum residue level estimations on the root and tuber vegetables group. Radishes Supervised trials data for thiamethoxam uses on radishes were available from the USA. In the USA, thiamethoxam may be used in a single foliar application to radishes at. kg ai/ha, with harvest permitted days after the application. Thiamethoxam may also be used as a soil surface band with incorporation after sowing with an application rate of. kg ai/ha for radishes. In six radish trials in the USA matching the foliar GAP conditions, thiamethoxam residues in radish roots in rank order were: (4),. and. mg/kg. In the same six trials, residues of CGA 224 in radish roots did not exceed the LOQ (. mg/kg). In six radish trials in the USA matching the foliar GAP conditions, thiamethoxam residues in radish tops in rank order were:.,.,.,.8,. and.64 mg/kg. In the same six trials, residues of CGA 224 in radish tops in rank order were:.2,.2,.,.4,.5 and. mg/kg. The Meeting noted that both the thiamethoxam and CGA 224 residue concentrations in radish tops fell within the maximum residue levels estimated for the leafy vegetables group. In four radish trials in the USA matching the soil surface band application GAP conditions, thiamethoxam residues in radish roots in rank order were: () and.2 mg/kg. In the same four trials, residues of CGA 224 in radish roots did not exceed the LOQ (. mg/kg). In four radish trials in the USA matching the soil surface band application GAP conditions, thiamethoxam residues in radish tops in rank order were:,.9,.9 and.8 mg/kg. In the same four trials, residues of CGA 224 in radish tops in rank order were:,. and. mg/kg. Sugar beet Supervised trials data for thiamethoxam uses on sugar beets were available from France, Germany, Italy, etherlands, Spain, Switzerland and the UK. o suitable GAP information was available to evaluate the trials from Italy, Spain and Switzerland. In the UK, thiamethoxam is registered for use as an FS formulation on sugar beet seeds at 6 g ai per, seeds. In nine sugar beet trials in Europe (France three, Germany three, etherlands one, Sweden one and the UK one) matching UK seed treatment GAP conditions, thiamethoxam residues in harvested sugar beets did not exceed LOQ (.2 mg/kg). In the same nine trials, residues of CGA 224 in sugar beets also did not exceed LOQ (.2 mg/kg). Summary Root and tuber vegetables Residue data with suitable GAP were available for carrots, radishes, potatoes and sugar beets. Residues were highest in potatoes and the Meeting decided to estimate root and tuber vegetables group maximum residue levels based on the potatoes data. On the basis of the potato seed piece treatment with thiamethoxam FS and DS in 6 US trials, the Meeting estimated a maximum residue level of. mg/kg for thiamethoxam on root and tuber vegetables. On the basis of the CGA 224 data on potatoes from the same 6 trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on root and tuber vegetables. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of. and.2 mg/kg respectively for thiamethoxam residues in root and tuber vegetables.

193 Thiamethoxam 99 The Meeting estimated STMR and HR values of. and.5 mg/kg respectively for CGA 224 residues in root and tuber vegetables. Stalk and stem vegetables Supervised trials data were available for artichokes and celery. Artichoke, Globe Supervised trials data for thiamethoxam uses on globe artichokes were available from the USA. In the USA, thiamethoxam WG may be used in foliar applications to globe artichokes at.5 kg ai/ha, with harvest permitted 4 days after an application. In three globe artichoke trials in the USA matching foliar GAP conditions, thiamethoxam residues in globe artichokes in rank order were:.,.2 and.24 mg/kg. In the same three trials, residues of CGA 224 in globe artichokes in rank order were:.2,.24 and.29 mg/kg. Globe artichoke is a minor crop and the Meeting agreed to evaluate the data. The Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on globe artichokes. On the basis of the CGA 224 data on globe artichokes from the same three trials, the Meeting estimated a maximum residue level of.5 mg/kg for CGA 224 on globe artichokes. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.2 and.24 mg/kg respectively for thiamethoxam residues in globe artichokes. The Meeting estimated STMR and HR values of.24 and.29 mg/kg respectively for CGA 224 residues in globe artichokes. Celery Supervised trials data for thiamethoxam uses on celery were available from the USA. In the USA, thiamethoxam WG may be used in foliar applications on leafy vegetables (includes celery) at.96 kg ai/ha, with harvest permitted days after an application. Thiamethoxam may also be used as a soil drench treatment at sowing or planting of leafy vegetables at.9 kg ai/ha. Trials with the drench treatment could not be evaluated because the trial rate did not match the GAP rate. In six celery trials in the USA matching the foliar GAP conditions, thiamethoxam residues in celery in rank order were:.9,.,.6,.25,.8 and.4 mg/kg (AFTA calculator:.92. OECD calculator Mean + 4SD:.82). In the same six trials, residues of CGA 224 in celery in rank order were: (4),. and.2 mg/kg. On the basis of the foliar applications on celery in six US trials, the Meeting estimated a maximum residue level of mg/kg for thiamethoxam on celery. On the basis of the CGA 224 data on celery from the same six trials, the Meeting estimated a maximum residue level of.4 mg/kg for CGA 224 on celery. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of.2 and.4 mg/kg respectively for thiamethoxam residues in celery. The Meeting estimated STMR and HR values of. and.2 mg/kg respectively for CGA 224 residues in celery. Cereal grains Supervised trials data were available for barley, maize, popcorn, rice and wheat. Barley Supervised trials data were available for barley from France, Germany, the UK and the USA.

194 98 Thiamethoxam In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on barley at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In 24 barley seed-treatment trials in Europe (France 9, Germany two and the UK three) with conditions (application rates.5.8 g ai/kg seed) approximately aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in barley grain from 2 trials did not exceed LOQ (.2 mg/kg), while.2 mg/kg was recorded in grain from one trial. In the same 24 trials, residues of CGA 224 in barley grain also did not exceed LOQ (.2 mg/kg). US GAP for barley allows the use of thiamethoxam WG for foliar applications at. kg ai/ha with a 2 days PHI. In nine barley trials in the USA matching the foliar GAP conditions, thiamethoxam residues in barley in rank order were: (),.,.2,.,.,.5 and.2 mg/kg (AFTA calculator:..25. OECD calculator Mean + 4SD:.4). In the same nine trials, residues of CGA 224 in barley in rank order were: (),. and.2 mg/kg. These data sets were selected for maximum residue level estimations. On the basis of the foliar applications on barley in nine US trials, the Meeting estimated a maximum residue level of.4 mg/kg for thiamethoxam on barley. On the basis of the CGA 224 data on barley from the same nine trials, the Meeting estimated a maximum residue level of.4 mg/kg for CGA 224 on barley. The same data were used for STMR estimates. The Meeting estimated an STMR value of.2 mg/kg for thiamethoxam residues in barley. The Meeting estimated an STMR value of. mg/kg for CGA 224 residues in barley. Maize Supervised trials data for thiamethoxam seed treatment uses on maize were available from France, Germany, Spain and the USA. In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on maize at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. The European supervised trials on maize were evaluated with the seed treatment GAP of the Czech Republic and Romania. In 24 maize seed-treatment trials in Europe (France 5, Germany six, and Spain three) with conditions aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in maize grain from 2 trials did not exceed LOQ (.2 mg/kg), while.4 mg/kg was recorded in grain from one trial. In the same 24 trials, residues of CGA 224 in maize grain also did not exceed LOQ (.2 mg/kg). In the USA, thiamethoxam is formulated as an FS seed treatment that may be used on maize at.25 mg ai per kernel. This is equivalent to approx 4.5 g ai/kg seed for a single kernel weight of. g. In 2 maize trials in the USA matching the US seed treatment GAP conditions, thiamethoxam residues in maize grain did not exceed LOQ (. mg/kg). In the same 2 trials, residues of CGA 224 in maize grain also did not exceed LOQ (. mg/kg). In two trials with a seed treatment rate of.5 g ai/kg seed ( the label rate), residues of thiamethoxam and CGA 224 also did not exceed LOQ (. mg/kg). The maize metabolism studies showed that very low concentrations of thiamethoxam and metabolite CGA 224 could occur in the maize grain from a seed treatment. On the basis of the seed treatment uses on maize in 24 European trials, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on maize. On the basis of the CGA 224 data on maize from the same 24 trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on maize.

195 Thiamethoxam 98 The same data were used for STMR estimates. The Meeting estimated an STMR value of.2 mg/kg for thiamethoxam residues in maize. The Meeting also estimated an STMR value of.2 mg/kg for CGA 224 residues in maize. Popcorn Supervised trials data for thiamethoxam use on popcorn were available from the USA. In the USA, thiamethoxam is formulated as an FS seed treatment that may be used on popcorn at.25 mg ai per kernel. This is equivalent to approx 4.5 g ai/kg seed for a single kernel weight of. g. In three popcorn trials in the USA where the seed had been treated with thiamethoxam FS at 4.5 g ai/kg seed, thiamethoxam residues and CGA 224 residues in the harvested grain were all below LOQ (. mg/kg). The Meeting estimated a maximum residue level and an STMR value, both at. mg/kg for thiamethoxam in popcorn. The Meeting estimated a maximum residue level and an STMR value, both at. mg/kg for CGA 224 in popcorn. Rice Supervised trials data were available for rice from Brazil and Japan. In Japan, thiamethoxam formulated as an SC may be applied to rice as foliar sprays at a concentration of.65 kg ai/hl. A days PHI is observed. Thiamethoxam GR may also be used as a seed-box treatment at.8 g ai per litre of soil. In two reverse-decline rice trials in Japan with seed-box treatment and foliar application aligned with GAP, residues of thiamethoxam in hulled rice grain were:.64 and.92 mg/kg. It should be noted that higher residues occurred at days PHI than at shorter intervals. In the same two trials, CGA 224 residues in the hulled rice grain were:.68 and.88 mg/kg. Brazil has a registered seed treatment use for thiamethoxam FS on rice at g ai per kg seed, i.e., g ai/kg seed. Thiamethoxam as a WG formulation may also be used in foliar applications on rice at.5 kg ai/ha with observation of a 2 days PHI. In three rice trials in Brazil with application conditions, seed treatment.4 g ai/kg seed, and foliar application at.5 kg ai/ha (% higher than label), thiamethoxam residues in rice grain were:, and. mg/kg. In three other trials with application conditions, seed treatment.4 g ai/kg seed, and foliar application at. kg ai/ha (25% lower than label), thiamethoxam residues in rice grain were:.2,.22 and.2 mg/kg. The data are apparently inconsistent with residues from the. kg ai/ha application rate approximately times as high as residues from the.5 kg ai/ha application rate. Residues of CGA 224 in the six trials (approximately label rate) from Brazil were,,,.2,. and.8 mg/kg. Six trials for rice is very minimal for a major crop and the Meeting decided not to estimate a maximum residue level. Wheat Supervised trials data were available for wheat from France, Germany, Switzerland and the UK. In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on wheat at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In 4 wheat seed-treatment trials in Europe (France, Germany two and the UK one) with conditions (application rates g ai/kg seed) approximately aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in wheat grain from 4 trials did not exceed

196 982 Thiamethoxam LOQ (.2 mg/kg). In the same 4 trials, residues of CGA 224 in wheat grain also did not exceed LOQ (.2 mg/kg). Hungarian GAP for wheat allows the use of thiamethoxam WG for foliar applications at.4 kg ai/ha with a days PHI. In 22 wheat trials in Europe (France, Germany four, Switzerland two and the UK three) with conditions aligned with the GAP of Hungary (but application rate.5 kg ai/ha instead of.4 kg ai/ha and eight trials also included seed treatments), thiamethoxam residues in wheat grain from 22 trials were: (6),.2,.2,.2,.,. and.4 mg/kg (AFTA calculator:.. OECD calculator Mean + 4SD:.42). In the same 22 trials, residues of CGA 224 in wheat grain did not exceed LOQ (.2 mg/kg). These data sets were selected for maximum residue level estimations. On the basis of the foliar applications on wheat in 22 European trials, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on wheat. On the basis of the CGA 224 data on wheat from the same 22 trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on wheat. The same data were used for STMR estimates. The Meeting estimated STMR values of.2 and.2 mg/kg respectively for thiamethoxam residues and CGA 224 residues in wheat. Tree nuts Pecans Supervised trials data were available for pecans from the USA. In the USA, a ZC (mixed formulation of CS capsule suspension and SC suspension concentrate) is registered for foliar application to pecans at.54 kg ai/ha. A days PHI is to be observed. Eight pecan trials were carried out at five sites in the USA. At three of the sites, application was made with a low-volume concentrated spray to simulate aerial application in one trial and as a high-volume dilute spray in the parallel trial. The remaining two sites had one trial each, one at high volume and the other at low volume. The trials included a second active ingredient, pymetrozine, as a tank mix. In eight pecan trials at five sites in the USA with foliar application of a thiamethoxam WG formulation at.4 kg ai/ha and pecan harvest at 2 or days after the second application, residues of thiamethoxam in pecan kernels did not exceed the LOQ (. mg/kg). In the same eight trials, residues of CGA 224 in pecan kernels also did not exceed the LOQ (. mg/kg). On the basis of the foliar applications on pecans in eight US trials, the Meeting estimated a maximum residue level of. mg/kg for thiamethoxam on pecans. On the basis of the CGA 224 data on pecans from the same eight trials, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 on pecans. The same data were used for STMR and HR estimates. The Meeting estimated STMR and HR values of. and. mg/kg for thiamethoxam residues in pecans. The Meeting also estimated STMR and HR values of. and. mg/kg for CGA 224 residues in pecans. Oilseed Supervised trials data were available for cotton seed, oilseed rape and sunflower. Cotton Supervised trials data were available for cotton from Greece, Spain and the USA. In the USA, a thiamethoxam FS formulation is registered for seed-treatment of cotton seed at..4 mg ai per seed. For a mg cotton seed this would translate to..4 g ai/kg seed.

197 Thiamethoxam 98 Thiamethoxam is also registered for foliar use on cotton at. kg ai/ha, with observation of a 2 days PHI. In the cotton trials from the US, the seed treatment rate was in accord with US GAP, but foliar application rates in the trials (.2,.45,.5,.5 and.25 kg ai/ha) were not in accord with the GAP rate,. kg ai/ha, so it was not possible to evaluate the cotton trials data. In Spain, a thiamethoxam WG formulation is registered for foliar applications to cotton at.5 kg ai/ha with a PHI of days. In cotton trials in Europe (Greece eight and Spain five) matching the foliar GAP conditions of Spain, thiamethoxam residues in cotton seed did not exceed the LOQ (.2 mg/kg). In the same trials, residues of CGA 224 in cotton seed also did not exceed the LOQ (.2 mg/kg). Some of the trials had also included a thiamethoxam seed treatment at.9 2. g ai/kg seed, but it is expected that the foliar treatment would produce the higher residues; in this case residue levels did not exceed the LOQ from the combined uses. The residue data were reported for dehulled seed and cotton hulls separately. Residues of thiamethoxam and CGA 224 in cotton hulls were also below LOQ (.5 mg/kg) in all samples. Oilseed rape Supervised trials data were available for seed treatment uses on oilseed rape from France, Germany, Sweden and the UK. In Germany and the UK, thiamethoxam FS formulations are registered for use as seed treatments on rapeseed at 42 g ai per kg seed. In trials in France, nine in Germany, one in Sweden and five in the UK where rapeseed was treated with thiamethoxam in WS or FS formulations, then sown and the crop grown to maturity, residues of thiamethoxam in rapeseed were all below LOQ (.2 mg/kg). Residues of metabolite CGA 224 in rapeseed were also all below LOQ (.2 mg/kg) in the same trials. Sunflowers Supervised trials data were available for sunflowers from the USA. In the USA, a thiamethoxam FS formulation is registered for seed-treatment of sunflower seeds at.25 mg ai per seed. For a 6 mg sunflower seed this would translate to g ai/kg seed. In eight sunflower trials in the USA matching the GAP conditions, thiamethoxam residues in sunflower seeds did not exceed the LOQ (. mg/kg). In the same eight trials, residues of CGA 224 in sunflower seeds also did not exceed the LOQ (. mg/kg). Residues of thiamethoxam and CGA 224 also did not exceed LOQ (. mg/kg) in two trials where seed treatment rates were 2.2 and. g ai/kg seed ( the label rate), suggesting a nil residue situation. Summary Oilseeds Residue data with suitable GAP were available for sunflowers, cotton and oilseed rape. The Meeting noted that thiamethoxam and CGA 224 residues were mostly below LOQ, but were highest in cotton seed and decided to estimate oilseed group maximum residue levels based on the cotton seed data set. On the basis of the foliar applications on cotton in European trials, the Meeting estimated a maximum residue level of.2 mg/kg for thiamethoxam on oilseed. On the basis of the CGA 224 data on cotton seed from the same trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on oilseed. The same data were used for STMR estimates. The Meeting estimated STMR values of.2 and.2 mg/kg respectively for thiamethoxam residues and CGA 224 residues in oilseed.

198 984 Thiamethoxam Seed for beverages and sweets Cacao Supervised trials data were available for foliar application of thiamethoxam in the production of cacao beans in Côte d'ivoire. In Cameroon, thiamethoxam WG is registered for foliar application to cacao at.25 kg ai/ha. A PHI of days is to be observed. In four cacao trials in Côte d'ivoire matching the GAP conditions of Cameroon, thiamethoxam residues in fermented dried cacao beans did not exceed the LOQ (.2 mg/kg). In the same four trials, residues of CGA 224 in dried cacao beans also did not exceed the LOQ (.2 mg/kg). On the basis of the foliar applications on cacao in four Côte d'ivoire trials, the Meeting estimated a maximum residue level of.2 mg/kg for thiamethoxam on dried cacao beans. On the basis of the CGA 224 data from the same four trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on dried cacao beans. The same data were used for STMR estimates. The Meeting estimated STMR values of.2 and.2 mg/kg respectively for thiamethoxam residues and CGA 224 residues in dried cacao beans. Coffee Supervised trials data were available for thiamethoxam uses in the production of coffee beans in Brazil. In Brazil, thiamethoxam may be used in soil treatments in the production of coffee GR granules applied to the soil at. kg ai/ha, max annual dose.6 kg ai/ha; PHI 9days;WG drench on soil under coffee tree at.5 kg ai/ha, PHI 9 days. In six coffee trials in Brazil matching the GAP conditions of GR treatment of the soil, thiamethoxam residues in coffee beans in rank order were:.2,.2,.2,.2,. and.4 mg/kg. In the same six trials, residues of CGA 224 in coffee beans in rank order were: (4),.2 and.2 mg/kg. In six coffee trials in Brazil matching the GAP conditions of WG drench treatment of the soil, thiamethoxam residues in coffee beans in rank order were:.2,.,.,.4,.4 and.6 mg/kg (AFTA calculator:.82. OECD calculator *Mean:.). In the same six trials, residues of CGA 224 in coffee beans in rank order were: (),.2,.2 and. mg/kg (AFTA calculator:.46. OECD calculator Mean + 4SD:.49). These data sets were selected for maximum residue level estimations. The Meeting noted that the trials with granular soil treatments produced residues of the same order as those from the drench treatment and provided support for the six soil drench trials. On the basis of the six Brazilian trials with soil drench treatments, the Meeting estimated a maximum residue level of.2 mg/kg for thiamethoxam on coffee beans. On the basis of the CGA 224 data on coffee beans from the same six trials, the Meeting estimated a maximum residue level of.5 mg/kg for CGA 224 on coffee beans. The same data were used for STMR estimates. The Meeting estimated STMR values of.5 and.5 mg/kg respectively for thiamethoxam residues and CGA 224 residues in coffee beans.

199 Thiamethoxam 985 Legume animal feeds Pea fodder Supervised trials data for thiamethoxam seed treatment uses on peas producing dry peas were available from the USA, Denmark, France and Germany. Residue data on pea vines and fodder were also provided. In the Czech Republic, thiamethoxam is registered for use as an FS formulation for pea seed treatment at 5 g ai per kg seed (.5 g ai/kg seed). In 2 pea trials in Europe (Denmark two, France six and Germany four) with seeds treated with thiamethoxam at.5 g ai/kg seed (Czech Republic GAP), residues of thiamethoxam in the harvested haulm at maturity, i.e., the pea fodder, in rank order were:.2 <.4, <.5 (6),.6,.,.8 and.2 mg/kg. In the same 2 trials, residues of CGA 224 in the pea fodder were:.2, <.4 (2), <.5 (6), <. (2) and.9 mg/kg. On a dry-weight basis (DM = 88%), thiamethoxam residues in pea fodder were (n = 2):.2, <.4, <.5 (6),.,.,.2 and.24 mg/kg (AFTA calculator:.29. OECD calculator Mean + 4SD:.6). Residues of CGA 224 in the pea fodder, dry weight, were (n = 2):.2, <.4 (2), <.5 (6), <. (2) and. mg/kg (AFTA calculator:.9). The Meeting estimated a maximum residue level of. mg/kg for thiamethoxam on pea fodder. On the basis of the CGA 224 data from the same 2 trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on pea fodder. The same data were used for STMR and highest residue estimates. The Meeting estimated STMR and highest residue values of.5 and.24 mg/kg respectively for thiamethoxam residues in pea fodder. The Meeting estimated STMR and highest residue values of.5 and. mg/kg respectively for CGA 224 residues in pea fodder. In of the same pea trials in Europe, residue data were available on whole plant (pea vines) sampled approximately 5 days after sowing. Residues of thiamethoxam in the pea whole plant, in rank order were: <.5(4),.2,.4,.5,.5,.,. and. mg/kg. In the same trials, residues of CGA 224 in the pea whole plant were: <.4 (4) and <.5 () mg/kg. The Meeting estimated STMR and highest residue values of.4 and. mg/kg respectively for thiamethoxam residues in pea vines. The Meeting estimated STMR and highest residue values of.5 and.5 mg/kg respectively for CGA 224 residues in pea vines. Straw, fodder and forage of cereal grains Maize forage and fodder Supervised trials data for thiamethoxam seed treatment uses on maize were available from France, Germany, Spain and the USA. In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on maize at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. The supervised trials on maize from Europe were evaluated with the seed treatment GAP of the Czech Republic and Romania. In 22 maize seed-treatment trials in Europe (France 5, Germany six and Spain one) with conditions aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in maize fodder from all trials did not exceed LOQ (.2 (),.4 (8) and.5 mg/kg ()). In the same 22 trials, residues of CGA 224 in maize fodder also did not exceed LOQ (same LOQs). In of these trials (France five and Germany five), residues were measured on the whole plant at an earlier stage, i.e., maize forage. Thiamethoxam residues in maize forage in these trials did not exceed LOQ (.2 (5),.4 (2) and.5 mg/kg ()). In the same trials, residues of CGA 224 in maize forage also did not exceed LOQ (same LOQs).

200 986 Thiamethoxam In the USA, thiamethoxam is formulated as an FS seed treatment that may be used on maize or sweet corn at.25 mg ai per kernel. This is equivalent to approx 4.5 g ai/kg seed for a single kernel weight of. g. In 5 maize and sweet corn trials in the USA matching the US seed treatment GAP conditions, thiamethoxam residues in maize stover (maize fodder) were: (),.,.,.2 and. mg/kg. In the same 5 trials, residues of CGA 224 in maize fodder did not exceed LOQ (. mg/kg). On a dry-weight basis (DM = 8%), thiamethoxam residues in maize fodder were (n = 5): (),.,.,.2 and.4 mg/kg. These data sets were selected for maximum residue level estimations. In maize and sweet corn trials in the USA matching the US seed treatment GAP conditions, thiamethoxam residues in maize forage were: (),.,.,.,.,.,.2,.2,.2,.2,.2,.4,.4,.4,.4,.4 and.5 mg/kg. In the same trials, residues of CGA 224 in maize forage were: (),.,. and.2 mg/kg. The Meeting estimated STMR and highest residue values of. and.5 mg/kg for thiamethoxam in maize forage. The Meeting also estimated STMR and highest residue values of. and.2 respectively for CGA 224 in maize forage. On the basis of the seed treatment uses on maize and sweet corn in 5 US trials, the Meeting estimated a maximum residue level of.5 mg/kg for thiamethoxam on maize fodder. On the basis of the CGA 224 data on maize fodder from the same 5 trials, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 on maize fodder. The same data were used for STMR and highest residue estimates. The Meeting estimated STMR and highest residue values of. and.4 mg/kg respectively for thiamethoxam residues in maize fodder. The Meeting estimated STMR and highest residue values of. and. mg/kg for CGA 224 residues in maize fodder. Barley straw and fodder Supervised trials data were available for barley from France, Germany, the UK and the USA. US GAP for barley allows the use of thiamethoxam WG for foliar applications at. kg ai/ha with a 2 days PHI. In eight barley trials in the USA matching the foliar GAP conditions, thiamethoxam residues in barley straw in rank order were:,.,.,.9,.26,.2 and. mg/kg. In the same eight trials, residues of CGA 224 in barley straw in rank order were: (),.,.2,.,. and. mg/kg. In the same eight barley trials in the USA matching the foliar GAP conditions, thiamethoxam residues in barley hay in rank order were:,.2,.2,.2,.2,.25 and.2 mg/kg. In the same eight trials, residues of CGA 224 in barley hay in rank order were: (),.,.2,.2,.2 and. mg/kg. In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on barley at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In 24 barley seed treatment trials in Europe (France 9, Germany two and the UK three) with conditions (application rates.5.8 g ai/kg seed) approximately aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in barley straw from the 24 trials did not exceed LOQ (.2.5 mg/kg). In the same 24 trials, residues of CGA 224 in barley straw also did not exceed LOQ (.2.5 mg/kg) in 2 of the trials with a CGA 224 residue of.4 mg/kg recorded in one barley straw. In of the same barley seed-treatment trials in Europe (France nine and Germany one), residues were measured on barley whole plant. Thiamethoxam residues in barley whole plant were:, <.4 (5), <.5,.5,.5 and. mg/kg. In the same trials, residues of CGA 224 in barley whole plant did not exceed LOQ (.2.5 mg/kg).

201 Thiamethoxam 98 The Meeting estimated STMR and highest residue values of.4 and. mg/kg respectively for thiamethoxam residues in barley whole plant. The Meeting estimated STMR and highest residue values of.4 and.5 mg/kg respectively for CGA 224 residues in barley whole plant. Wheat straw and fodder Supervised trials data, including data on wheat straw and fodder, were available for wheat from France, Germany, Switzerland and the UK. In the Czech Republic and Romania, thiamethoxam is formulated as an FS seed treatment that may be used on wheat at 5 g ai per kg seed, i.e.,.5 g ai/kg seed. In 4 wheat seed-treatment trials in Europe (France, Germany two and the UK one) with conditions (application rates g ai/kg seed) approximately aligned with the GAP of the Czech Republic and Romania, thiamethoxam residues in wheat straw from 4 trials did not exceed LOQ (.4.5 mg/kg). In the same 4 trials, residues of CGA 224 in wheat straw also did not exceed LOQ (.4.5 mg/kg), except for one trial: CGA 224 residue =.5 mg/kg. In 2 of the same wheat seed-treatment trials in Europe (France and Germany one), residues were measured on wheat whole plant. Thiamethoxam residues in wheat whole plant were: (4), <.4 (5),.2,.2 and.5 mg/kg. In the same trials, residues of CGA 224 in wheat were: (), <.4 (5), <.5,.2,.2 and.2 mg/kg. Hungarian GAP for wheat allows the use of thiamethoxam WG for foliar applications at.4 kg ai/ha with a days PHI. In 2 wheat trials in Europe (France, Germany two, Switzerland two and the UK three) with conditions aligned with the GAP of Hungary (but application rate.5 kg ai/ha instead of.4 kg ai/ha and six trials also included a seed treatment), thiamethoxam residues in wheat straw from 2 trials were: <.4,.5,.,.5,.,.22,.25,.,.2,.,.4,.5,.,.42,.44,.5,.5,.65,.8,.4 and.5 mg/kg. In the same 2 trials, residues of CGA 224 in wheat straw were: <.4 (8), <.5 (5),.,.4,.6,.,.8,.,. and.2 mg/kg. On a dry-weight basis (DM = 88%), thiamethoxam residues in wheat straw were (n = 2): <.4,.6,.6,.,.9,.25,.,.2,.6,.8,.9,.4,.42,.48,.5,.58,.58,.4,.9,.6 and. mg/kg. On a dry-weight basis (DM=88%), CGA 224 residues in wheat straw were (n = 2): <.4 (8), <.5 (5),.,.5,.,.8,.9,.,. and. mg/kg. These datasets were used for MRL estimation. In 2 of these same wheat trials in Europe (France and Germany two) with conditions aligned with the GAP of Hungary (but application rate.5 kg ai/ha instead of.4 kg ai/ha and six trials also included a seed treatment), thiamethoxam residues were measured on wheat whole plants or equivalent: <.4,.,.8,.4,.5,.5,.55,.58,.6,.6,.66 and. mg/kg. In the same 2 trials, residues of CGA 224 in wheat whole plants were: <.4 (5), <.5 (),.4,.5,.5 and.6 mg/kg. The Meeting estimated STMR and highest residue values of.5 and. mg/kg respectively for thiamethoxam residues in wheat whole plants. The Meeting estimated STMR and highest residue values of.5 and.6 mg/kg respectively for CGA 224 residues in wheat whole plant. Rice straw Data were available for rice straw from two supervised trials, but this was insufficient for an evaluation. Summary of 'Barley straw and fodder' and 'Wheat straw and fodder' Barley straw and fodder, and wheat straw and fodder, as commodities of trade, may not always be readily distinguishable from each other. It is therefore preferable for the two commodities to have the same MRLs.

202 988 Thiamethoxam Thiamethoxam residues in wheat straw from 2 trials were: <.4,.5,.,.5,.,.22,.25,.,.2,.,.4,.5,.,.42,.44,.5,.5,.65,.8,.4 and.5 mg/kg. Thiamethoxam residues in barley straw from eight trials were:,.,.,.9,.26,.2 and. mg/kg. Residues of CGA 224 in wheat straw were: <.4 (8), <.5 (5),.,.4,.6,.,.8,.,. and.2 mg/kg. Residues of CGA 224 in barley straw were: (),.,.2,.,. and. mg/kg. In this case, residues in wheat straw were higher than in the barley straw. The Meeting agreed to use the wheat straw data for both the barley straw and fodder MRL, and the wheat straw and fodder MRL. On a dry-weight basis (DM = 88%), thiamethoxam residues in wheat straw were (n = 2): <.4,.6,.6,.,.9,.25,.,.2,.6,.8,.9,.4,.42,.48,.5,.58,.58,.4,.9,.6 and. mg/kg (AFTA calculator: OECD calculator Mean + 4SD: 2.246). On a dry-weight basis (DM = 88%), CGA 224 residues in wheat straw were (n = 2): <.4 (8), <.5 (5),.,.5,.,.8,.9,.,. and. mg/kg (AFTA calculator:.9. OECD calculator Mean + 4SD:.8). On the basis of the foliar applications on wheat in 2 European trials, the Meeting estimated a maximum residue level of 2 mg/kg for thiamethoxam on wheat straw and fodder, dry. On the basis of the CGA 224 data on wheat straw from the same 2 trials, the Meeting estimated a maximum residue level of.2 mg/kg for CGA 224 on wheat straw and fodder, dry. The same data were used for STMR and highest residue estimates. The Meeting estimated STMR and highest residue values of.9 and. mg/kg respectively for thiamethoxam residues in wheat straw and fodder, dry. The Meeting estimated STMR and highest residue values of.5 and. mg/kg respectively for CGA 224 residues in wheat straw and fodder, dry. On the basis of these same wheat data, the Meeting estimated a maximum residue level of 2 mg/kg for thiamethoxam on barley straw and fodder, dry, and a maximum residue level of.2 mg/kg for CGA 224 on barley straw and fodder, dry. The Meeting also estimated STMR and highest residue values of.9 and. mg/kg respectively for thiamethoxam residues in barley straw and fodder, dry, and STMR and highest residue values of.5 and. mg/kg respectively for CGA 224 residues in barley straw and fodder, dry. Miscellaneous fodder and forage crops Sugar beet leaves and tops Supervised trials data for thiamethoxam uses on sugar beets, including data on leaves and tops, were available from France, Germany, etherlands, Spain, Switzerland and the UK. o suitable GAP information was available to evaluate the trials from Italy, Spain and Switzerland. In the UK, thiamethoxam is registered for use as an FS formulation on sugar beet seeds at 6 g ai per, seeds. In sugar beet trials in Europe (France three, Germany three, etherlands one, Spain one, Sweden one and the UK one) matching UK seed treatment GAP conditions (application rate 6 5 g ai per, seeds), thiamethoxam residues in sugar beet tops or leaves did not exceed LOQ (.2 mg/kg). CGA 224 residues in sugar beet tops or leaves also did not exceed LOQ (.2 mg/kg). The data were used for STMR and highest residue estimates. The Meeting estimated STMR and highest residue values of.2 and.2 mg/kg for thiamethoxam residues in sugar beet tops or leaves. The Meeting estimated STMR and highest residue values of.2 and.2 mg/kg also for CGA 224 residues in sugar beet tops or leaves.

203 Thiamethoxam 989 Rape seed forage and fodder Supervised trials data were available for seed treatment uses on oilseed rape from France, Germany, Sweden and the UK. In Germany and the UK, thiamethoxam FS formulations are registered for use as seed treatments on rapeseed at 42 g ai per kg seed. In four trials in France, seven in Germany, one in Sweden and two in the UK where rapeseed was treated with thiamethoxam at the GAP rate, then sown and the forage sampled months later, residues of thiamethoxam in rapeseed plant were all below LOQ (.5 mg/kg). Residues of metabolite CGA 224 in rapeseed plant were also all below LOQ (.5 mg/kg) in the same trials. In seven trials in Germany and one in Sweden where rapeseed was treated with thiamethoxam at the GAP rate, then sown and the crop grown to maturity, residues of thiamethoxam in rapeseed straw were all below LOQ (.5 mg/kg). Residues of metabolite CGA 224 in rapeseed straw were also all below LOQ (.5 mg/kg) in the same trials. The data were used for STMR and highest residue estimates. The Meeting estimated STMR and highest residue values of.5 and.5 mg/kg for thiamethoxam residues in rapeseed forage. The Meeting estimated STMR and highest residue values of.5 and.5 mg/kg also for CGA 224 residues in rapeseed forage. Cotton gin by-products Supervised trials data were available for seed treatment and foliar uses on cotton from the USA. In the USA, a thiamethoxam FS formulation is registered for seed-treatment of cotton seed at..4 mg ai per seed. For a mg cotton seed this would translate to..4 g ai/kg seed. Thiamethoxam is also registered for foliar use on cotton at. kg ai/ha, with observation of a 2 days PHI. In the cotton trials from the US, the seed treatment rate was in accord with US GAP, but foliar application rates in the trials (.2,.45,.5,.5 and.25 kg ai/ha) were not in accord with the GAP rate,. kg ai/ha, so it was not possible to evaluate the cotton trials residue data on gin trash. Dried herbs Hops Supervised trials data for thiamethoxam use on hops were available from the USA. Thiamethoxam may be used in the USA as a soil surface band application with incorporation during the production of hops. The application rate is. kg ai/ha and the PHI is 65 days. In three hops trials in the USA matching the GAP conditions, thiamethoxam residues in hops dry cones in rank order were: 5,.2 and.55 mg/kg. In the same three trials, residues of CGA 224 in hops dry cones in rank order were: 5,.25 and. mg/kg. The Meeting agreed that three trials are insufficient for maximum residue level estimation on hops. Teas Supervised trials data for thiamethoxam use on tea were available from Japan. In Japan, thiamethoxam SG (soluble granule) formulation is registered for foliar application during the production of tea. The spray concentration is.5 kg ai/hl and the PHI is days. Immediately after harvest in the tea trials in Japan, the leaves were processed with an inhouse tea processing machine and then enclosed in aluminium bags for delivery to the laboratory. The processing consisted of drying, breaking the leaves to expose enzymes and tissues to oxidation and allowing a period of oxidation by exposure in the air.

204 99 Thiamethoxam In six tea trials in Japan matching the GAP conditions, thiamethoxam residues in crude processed tea leaves in rank order were: 2., 2., 2., 5.5,. and 8.6 mg/kg (AFTA calculator: OECD calculator Mean + 4SD: 5.6). In the same six trials, residues of CGA 224 in crude processed tea leaves in rank order were:.6,.8,.8,.6,.25 and. mg/kg (AFTA calculator:.58. OECD calculator Mean + 4SD:.5). The Meeting estimated a maximum residue level of 2 mg/kg for thiamethoxam on tea, green and black. On the basis of the CGA 224 data on tea from the same six trials, the Meeting estimated a maximum residue level of. mg/kg for CGA 224 on tea, green and black. The same data were used for STMR estimates. The Meeting estimated an STMR value of 4. mg/kg for thiamethoxam residues in tea. The Meeting estimated an STMR value of.2 mg/kg for CGA 224 residues in tea. Fate of residues during food processing The Meeting received information on the fate of thiamethoxam residues during the processing of apples to juice and pomace; barley to pearled barley, barley bran, barley flour, beer, wort and malt; coffee beans to roasted coffee; cotton seed to meal and refined oil; grapes to juice, pomace and wine; maize to grits, flour, oil and starch; oranges to pulp, juice and oil; plums to dried prunes; potato to wet peelings, flakes and chips; tomatoes to juice, pulp, puree and paste; and wheat to semolina, bran, flour and bread. Also information was provided on hydrolysis studies of thiamethoxam to assist with identification of the nature of the residue during processing. Thiamethoxam was essentially stable during the hydrolysis conditions simulating food processing conditions. Processing factors have been calculated for thiamethoxam residues during the following processes: apples processing to juice and wet pomace; barley processing to pearled barley, bran, flour, and beer; coffee beans to roasted coffee; cotton seed to meal and oil; grapes to pomace and wine; oranges to pulp and juice; plums to dried prunes; tomatoes to juice, paste and puree; and wheat to semolina, wheat bran, wheat bread and wheat flour. Processing factors were also calculated for CGA 224 residues in the following processes: apples to apple juice and wet pomace; coffee beans to roasted coffee; plums to dried prunes; and tomatoes to paste and puree. Calculated processing factors are summarised in the following table. Factors are indicated with a '<' (less-than) sign when the residue in the processed commodity is below the LOQ of the analytical method. The calculation is then made on the LOQ of the analytical method and the residue concentration of the RAC (raw agricultural commodity). The medians of the observed values or the best estimates of the processing factors are summarised in the final column of the table. Only those processes are included in the table that lead to STMR-P or HR-P values useful for dietary intake estimations or for livestock dietary burden calculations. Raw agricultural commodity (RAC) Processed commodity Calculated processing factors. Median or best estimate THIAMETHOXAM Apple apple juice.2,.2,.8,.92,.94,., <.,.4.9 Apple wet pomace.8,.8,.4,.5,.6,.6,.9, Barley barley flour.8.8 Barley pearled barley Coffee beans roasted coffee <., <., <., <.2, <.2, <.2, <.25, <.25, <.25, <., <., <.5 <. Cotton seed cotton seed meal.5,.2,.2, <.,.49.2 Cotton seed cotton seed oil refined, <.8, <.9, <.2, <. Grapes dry pomace.4, Grapes wet pomace.,.5, 4..5

205 Thiamethoxam 99 Raw agricultural commodity (RAC) Processed commodity Calculated processing factors. Median or best estimate Grapes wine.,.,.9,.,.5,.,.6,.6,. Orange dried pulp 2., Orange orange juice <.25, <.5 <.25 Plum dried prunes.6,.8, <..8 Tomato tomato juice.6,..6 Tomato tomato paste.25, 2., 2.24, 2.4, 2.94, 2.94,.,.86,.9, 4.2, 4., 6.. Tomato tomato pulp.,.. Tomato tomato puree.4,.5,.64,.9,.6,.2,.,.5,.8, 2., 2.2, 2.5. Wheat semolina <. <. Wheat wheat bran Wheat wheat bread <. <. Wheat wheat flour <. <. CGA 224 Apple apple juice.,.,.. Apple wet pomace.4,,5,.5.5 Coffee beans roasted coffee <., <., <., <., <., <.5, <.5, <.5, <.5, <.5 <. Plum dried prunes.5, 2..5 Tomato tomato paste 2., 2.8,.,.5, 5.5, 5.8, 6., 6., 6.5, 6.5, 9.,. 5.9 Tomato tomato puree.5,.6,.,.9,.,.5, 2.5, 2.5,.,.44,.54, 6., 2. Thiamethoxam residues in tea were investigated for percentage infusion and, by inference, percentage consumption. Tea infusions were prepared by adding boiling water to dried and processed tea leaves from a thiamethoxam supervised residue trial and allowing to stand for 5 minutes. The infusion was filtered and analysed and the % infusion (% of residue extracted into the boiling water) was calculated. For thiamethoxam, the average % infusion was 9%, range 68 %, n = 2. For CGA 224, average % infusion was 94%, range 8 %, n =. The processing factors for thiamethoxam residues for oranges orange juice (.) and oranges orange dry pulp (2.6) were applied to the citrus fruits STMR,. mg/kg, to produce an orange juice STMR-P of. mg/kg and an orange dry pulp STMR-P of. mg/kg. The processing factors for thiamethoxam residues for apples apple juice (.9) and apples apple pomace (.55) were applied to the pome fruit STMR,. mg/kg, to produce an apple juice STMR-P of.65 mg/kg and an apple wet pomace STMR-P of. mg/kg. The processing factor for thiamethoxam residues for plums dried prunes (.8) was applied to the stone fruits STMR and HR,.95 and.6 mg/kg, to produce a dried prunes STMR-P of.6 mg/kg and an HR-P of.5 mg/kg. The processing factors for thiamethoxam residues for grapes wine () and grapes dry grape pomace (.9) were applied to the berry fruits STMR,.55 mg/kg, to produce a wine STMR-P of.55 mg/kg and a dry grape pomace STMR-P of.2 mg/kg. The processing factors for thiamethoxam residues for tomato tomato juice (.6), tomato tomato paste (), tomato tomato pulp () and tomato tomato puree (.) were applied to the fruiting vegetables STMR,.8 mg/kg, to produce a tomato juice STMR-P of.54 mg/kg, a tomato paste STMR-P of.24 mg/kg, a tomato pulp STMR-P of.8 mg/kg and a tomato puree STMR-P of.88 mg/kg. The processing factors for thiamethoxam residues for barley barley flour (.8) and barley pearled barley (.25) were applied to the barley STMR,.2 mg/kg, to produce a barley flour STMR-P of. mg/kg and a pearled barley STMR-P of. mg/kg.

206 992 Thiamethoxam The processing factors for thiamethoxam residues for wheat semolina (.), wheat wheat bran (), wheat wheat bread (.) and wheat wheat flour (.) were applied to the wheat STMR,.2 mg/kg, to produce a semolina STMR-P of. mg/kg, a wheat bran STMR-P of.2 mg/kg, a wheat bread STMR-P of. mg/kg and a wheat flour STMR-P of. mg/kg. The processing factors for thiamethoxam residues for cotton seed cotton seed meal (.2) and cotton seed refined cotton seed oil (.2) were applied to the oilseed STMR,.2 mg/kg, to produce a cotton seed meal STMR-P of.54 mg/kg and a refined cotton seed oil STMR-P of.4 mg/kg. The processing factor for thiamethoxam residues for coffee beans roasted coffee (.) was applied to the coffee beans STMR,.5 mg/kg, to produce a roasted coffee STMR-P of.49 mg/kg. The fate of CGA 224 residues during food processing is dealt with in the clothianidin evaluation. Residues in animal commodities The Meeting received a lactating dairy cow feeding study, which provided information on likely residues resulting in animal tissues and milk from thiamethoxam residues in the animal diet. Lactating Holstein dairy cows were dosed for 29 days once daily via gelatin capsule with thiamethoxam at the equivalent of 2, 6 and 2 ppm in the dry-weight diet. Parent thiamethoxam did not occur above LOQ (. mg/kg) in liver or fat tissues at the highest test dose. Parent thiamethoxam residues were higher in muscle than in other tissues, but residues did not exceed the LOQ at the 2 ppm dosing level. Metabolite CGA 224 did not occur above LOQ (. mg/kg) in any of the tissues except liver. At 2 ppm dosing, the only residues above LOQ in tissues were: CGA 224 in liver at..49 mg/kg. At 6 ppm dosing, residues above LOQ in tissues were: thiamethoxam in muscle at. mg/kg; CGA 224 in liver at.9. mg/kg. Residue levels of parent thiamethoxam and metabolite CGA 224 reached plateau levels in milk approximately 5 days after the commencement of dosing. At 2 and 6 ppm dosing, the approximate plateau levels for thiamethoxam in milk were..8 mg/kg and..5 mg/kg, respectively. For CGA 224, the plateau levels in milk at 6 ppm dosing were approximately..2 mg/kg. Livestock dietary burden The Meeting estimated the dietary burden of thiamethoxam in livestock on the basis of the diets listed in OECD Feed Table 29 (available from the FAO website: Calculation from highest residue, STMR (some bulk commodities) and STMR-P values provides the levels in feed suitable for estimating MRLs, while calculation from STMR and STMR-P values for feed is suitable for estimating STMR values for animal commodities. Some processed and forage commodities do not appear in the Recommendations Table (because no maximum residue level is needed) but they are used in estimating livestock dietary burdens. Those commodities are listed here. Also, the terminology for commodities in the OECD feed tables is not always identical to descriptions in the original studies or Codex descriptions and some clarification is needed.

207 Thiamethoxam 99 Commodity Thiamethoxam STMR or STMR-P, mg/kg High residue, mg/kg Apple wet pomace. Barley whole plant = Barley forage.4. Beans (dry) = Bean seed See Recommendations Table, pulses Cabbages (including wrapper leaves).8. Cotton seed meal = Cotton meal.54 Dry grape pomace.2 Maize = Field corn grain See Recommendations Table Maize fodder = Field corn, stover See Recommendations Table Maize forage = Field corn, forage/silage..5 Orange dry pulp = Citrus dried pulp. Pea hay or Pea fodder (dry) = Pea hay See Recommendations Table Pea vines.4. Peas (dry) = Pea seed See Recommendations Table, pulses Rapeseed forage.5.5 Soya bean (dry) = Soya bean seed See Recommendations Table, pulses Sugar beet tops or leaves = Beet, sugar tops.2.2 Wheat whole plant = Wheat forage.5. The data on CGA 224 residues in feed materials will be needed for dietary burden calculations for clothianidin. Commodity CGA 224 STMR or STMR- P, mg/kg High residue, mg/kg Barley whole plant.4.5 Beans (dry) = Bean seed See Recommendations Table Cabbages (including wrapper leaves)..8 Maize = Field corn grain See Recommendations Table Maize fodder = Field corn, stover See Recommendations Table Maize forage = Field corn, forage/silage..2 Pea hay or Pea fodder (dry) = Pea hay See Recommendations Table Pea vines.5.5 Peas (dry) = Pea seed See Recommendations Table Rapeseed forage.5.5 Soya bean (dry) = Soya bean seed See Recommendations Table Sugar beet tops or leaves = Beet, sugar tops.2.2 Wheat whole plant = Wheat forage.5.6 Estimated maximum and mean dietary burdens of livestock Dietary burden calculations for beef cattle, dairy cattle, broilers and laying poultry are provided in Annex 6 of the 2 Report of the JMPR. The calculations were made according to the livestock diets from US-Canada, EU, Australia and Japan in the OECD Feed Table 29. Livestock dietary burden, thiamethoxam, ppm of dry matter diet US-Canada EU Australia Japan Max beef cattle dairy cattle a,c 2..2 Poultry broiler Poultry layer..59 e.4.2 Mean beef cattle b. dairy cattle d.5. Poultry broiler...4. Poultry layer..59 f.4.2 a Highest maximum beef or dairy cattle dietary burden suitable for MRL estimates for mammalian meat. b Highest mean beef or dairy cattle dietary burden suitable for STMR estimates for mammalian meat. c Highest maximum dairy cattle dietary burden suitable for MRL estimates for milk.

208 994 Thiamethoxam d Highest mean dairy cattle dietary burden suitable for STMR estimates for milk. e Highest maximum poultry dietary burden suitable for MRL estimates for poultry meat and eggs. f Highest mean poultry dietary burden suitable for STMR estimates for poultry meat and eggs. Animal commodities maximum residue level estimation Cattle For MRL estimation, the high residues in the tissues were calculated by interpolating the maximum dietary burden (5.2 ppm) between the relevant feeding levels (2 and 6 ppm) from the dairy cow feeding study and using the highest tissue concentrations from individual animals within those feeding groups. The STMR values for the tissues were calculated by interpolating the STMR dietary burden (2.2 ppm) between the relevant feeding levels (2 and 6 ppm) from the dairy cow feeding study and using the mean tissue concentrations from those feeding groups. For milk MRL estimation, the high residues in the milk were calculated by interpolating the maximum dietary burden (5.2 ppm) between the relevant feeding levels (2 and 6 ppm) from the dairy cow feeding study and using the mean milk concentrations from those feeding groups. The STMR value for milk was calculated by interpolating the STMR dietary burden (.59 ppm) between the relevant feeding levels ( and 2 ppm) from the dairy cow feeding study and using the mean milk concentrations from those feeding groups. In the table, dietary burdens are shown in round brackets (), feeding levels and residue concentrations from the feeding study are shown in square brackets [] and estimated concentrations related to the dietary burdens are shown without brackets. Dietary burden (ppm) Thiamethoxam residues Feeding level [ppm] Milk Muscle Liver Kidney Fat MRL mean highest highest highest highest MRL beef cattle (5.2) [2, 6]. [,.] [, ] [, ] [, ] MRL dairy cattle (5.2) [2, 6] STMR STMR beef cattle (2.2) [2, 6] STMR dairy cattle (.59) [, 2]. [.,.] mean mean mean mean mean.6 [,.]. [,.] [, ] [, ] [, ] The data from the cattle feeding studies were used to support the estimation of maximum residue levels for mammalian meat and milk. Residues in milk were estimated as. and.6 mg/kg resulting from the maximum (5.2 ppm) and STMR (.59 ppm) dietary burdens respectively. The Meeting estimated a maximum residue level for thiamethoxam in milks of.5 mg/kg. The Meeting also estimated an STMR for milk of.6 mg/kg. The Meeting estimated a maximum residue level for thiamethoxam in edible offal of.* mg/kg. The estimation is based on the liver and kidney data. The Meeting estimated an STMR value and an HR value of. and. mg/kg for edible offal.

209 Thiamethoxam 995 For muscle, the residue arising from a dietary burden of 5.2 ppm was calculated as. mg/kg. The Meeting estimated a maximum residue level for meat as.2 mg/kg. STMR and HR values for muscle and fat were all estimated as. mg/kg. Cattle CGA 224 residues The residues of CGA 224 were evaluated in the same way as described above for thiamethoxam. In the table, dietary burdens are shown in round brackets (), feeding levels and residue concentrations from the feeding study are shown in square brackets [] and estimated concentrations related to the dietary burdens are shown without brackets. Dietary burden, CGA 224 residues thiamethoxam (ppm) Feeding level [ppm] Milk Muscle Liver Kidney Fat MRL mean highest highest highest highest MRL beef cattle (5.2) [2, 6] MRL dairy cattle (5.2) [2, 6] STMR STMR beef cattle (2.2) [2, 6] STMR dairy cattle (.59) [, 2]..5,.] [, ].2 a [.49,.] [, ] mean mean mean mean mean.4 [,.5] [, ].4 b [.9,.2] [, ] a Residue.2 mg/kg expressed as thiamethoxam is equivalent to. mg/kg expressed as CGA 224. b Residue.4 mg/kg expressed as thiamethoxam is equivalent to..5 mg/kg expressed as CGA 224. [, (2 ppm)] [, (2 ppm)] The CGA 224 data from the thiamethoxam cattle feeding studies were used to support the estimation of maximum residue levels for mammalian meat and milk. CGA 224 residues in milk were estimated as. and.4 mg/kg resulting from the maximum (5.2 ppm) and STMR (.59 ppm) dietary burdens respectively. The Meeting estimated a maximum residue level for CGA 224 in milks of.2 mg/kg. The Meeting also estimated a CGA 224 STMR for milk of.4 mg/kg. For liver, the CGA 224 residues arising from dietary burdens of 5.2 ppm and.59 ppm were. and.5 mg/kg, respectively. The Meeting estimated a maximum residue level for CGA 224 in liver of.2 mg/kg. The Meeting estimated an STMR value and an HR value of.5 and. mg/kg, respectively, for CGA 224 residues in liver. For kidney, the CGA 224 residue arising from a dietary burden of 5.2 ppm was calculated as mg/kg. The Meeting agreed to use the kidney data to estimate a maximum residue level for edible offal except liver. The Meeting estimated a maximum residue level for edible offal except liver as.* mg/kg. CGA 224 STMR and HR values for edible offal except liver were estimated as. mg/kg. For muscle, the CGA 224 residue arising from a dietary burden of 5.2 ppm was calculated as mg/kg. The Meeting estimated a maximum residue level for meat as.* mg/kg. STMR and HR values for muscle and fat were all estimated as. mg/kg.

210 996 Thiamethoxam Poultry The thiamethoxam maximum dietary burden for poultry is.59 ppm and the mean dietary burden is.59 ppm. o poultry feeding study is available for thiamethoxam, but the metabolism studies suggest that parent thiamethoxam would be unlikely to be present at measurable concentrations in poultry tissues or eggs from a dietary burden of.59 ppm. When laying hens in the metabolism studies were dosed with thiamethoxam at the equivalent of 2 and 98 ppm ( C-thiazolyl and C-oxadiazin, respectively) in the feed, parent thiamethoxam was found in lean meat and eggs at concentrations of..9 mg/kg and. mg/kg respectively. It may be reasonably anticipated that the levels of thiamethoxam in tissues and eggs resulting from a dietary burden of.59 mg/kg would be well below the LOQ of the analytical method (. mg/kg). Thiamethoxam was a very minor part of the residue in poultry liver, whereas CGA 224 constituted 4% and 9% of the liver TRR (8.2 and 9.2 mg/kg) in the poultry metabolism study with C labels in the thiazol and oxadiazin positions, respectively. Metabolite CGA 265 was the major residue component in the eggs, both whites (45% and 4%) and yolks (69% and 54%), and also in fat + skin (54% and 5%). The complexity of the metabolite mixture makes it difficult to select an ideal residue definition for risk assessment. In the two poultry metabolism studies, the lower dosing (equivalent to 98 ppm in diet) produced slightly higher TRR values for tissues and eggs, so was selected for the purpose of exposure assessment. TRR, mg/kg at dose equiv to 98 ppm in metabolism study For max residue level estimation Calculated TRR, mg/kg for dietary burden.59 ppm = TRR (.59/98) Calculated thiamethoxam, mg/kg, for dietary burden.59 ppm = TRR (.59/98) (%TRR/) Calculated CGA 224, mg/kg for dietary burden.59 ppm = TRR (.59/98) (%TRR/) For STMR estimation Calculated TRR, mg/kg for dietary burden.59 ppm = TRR (.59/98) Calculated thiamethoxam, mg/kg, for dietary burden.59 ppm = TRR (.59/98) (%TRR/) Calculated CGA 265, mg/kg for dietary burden.59 ppm = TRR (.59/98) (%TRR/) Calculated MU, mg/kg for dietary burden.59 ppm = TRR (.59/98) (%TRR/) Total of thiamethoxam + CGA MU (expressed as thiamethoxam) for dietary burden.59 ppm Calculated CGA 224, mg/kg for dietary burden.59 ppm = TRR (.59/98) (%TRR/) Concentrations, mg/kg, expressed as thiamethoxam Lean meat Fat + skin Liver Egg white Egg yolk (2% TRR).2 (.5% TRR). (5% TRR).5 (.% TRR). (.2% TRR).58 ote a (9% TRR). (.9% TRR). (2% TRR).5 (.% TRR). (2% TRR) (2% TRR).5 (8.4% TRR).6 (% TRR).2 (5.4% TRR). (.5% TRR). (5% TRR). (5% TRR). (.6% TRR).6 (65.6%).2 (.% TRR). (.2% TRR).88 (6% TRR).66 (2% TRR).6 (.2%).2 ote b (9% TRR). (.9% TRR).8 (4% TRR). (48.9%).4 (2% TRR) a Residue.58 mg/kg expressed as thiamethoxam is equivalent to.5 mg/kg expressed as CGA 224. b Residue.2 mg/kg expressed as thiamethoxam is equivalent to.8 mg/kg expressed as CGA (.% TRR).9 (54% TRR).2 (65.%).4 (2% TRR)

211 Thiamethoxam 99 On the basis of the calculated thiamethoxam residues in tissues and eggs (..2 mg/kg) for a dietary burden of.59 ppm, the Meeting estimated maximum residue levels of.* mg/kg for thiamethoxam in poultry meat, offal and eggs. On the basis of the calculated thiamethoxam + CGA MU residues (expressed as thiamethoxam) residues in lean meat (.2 mg/kg), liver (.6 mg/kg) and eggs (. mg/kg) for a dietary burden of.59 ppm, the Meeting estimated STMR values of. mg/kg for thiamethoxam in poultry meat and eggs and.6 mg/kg for poultry edible offal. Similar calculations were made for a dietary burden of.59 ppm. On the basis of the calculated thiamethoxam + CGA MU residues (expressed as thiamethoxam) residues in lean meat (.88 mg/kg), liver (.42 mg/kg) and eggs (. mg/kg) for a dietary burden of.59 ppm, the Meeting estimated HR values of. mg/kg for thiamethoxam in poultry meat and eggs and.42 mg/kg for poultry edible offal. On the basis of the calculated CGA 224 residues in lean meat (.2 mg/kg), liver (.5 mg/kg) and eggs (. mg/kg) for a thiamethoxam dietary burden of.59 ppm, the Meeting estimated maximum residue levels of.* mg/kg for CGA 224 in poultry meat,. mg/kg for poultry offal and.* mg/kg for eggs. On the basis of the calculated CGA 224 residues in lean meat (. mg/kg), liver (.8 mg/kg) and eggs (.4 mg/kg) for a thiamethoxam dietary burden of.59 ppm, the Meeting estimated STMR values of. mg/kg for CGA 224 in poultry meat and eggs and.8 mg/kg for poultry edible offal. On the basis of the calculated CGA 224 residues in lean meat (.2 mg/kg), liver (.5 mg/kg) and eggs (. mg/kg) for a thiamethoxam dietary burden of.59 ppm, the Meeting estimated HR values of. mg/kg for CGA 224 in poultry meat and eggs and.5 mg/kg for poultry edible offal. RECOMMEDATIOS On the basis of the data from supervised trials the Meeting concluded that the residue levels listed below are suitable for establishing maximum residue limits and for IEDI and IESTI assessment. The Meeting recommended the following residue definition for thiamethoxam. Definition of the residue for animal and plant commodities (for compliance with the MRL): thiamethoxam. Definition of the residue for plants and animals (except poultry), (for estimation of dietary intake): thiamethoxam; and CGA 224 (CGA 224 to be included with clothianidin and considered separately from thiamethoxam). See also clothianidin. Definition of the residue for poultry (for estimation of dietary intake): sum of thiamethoxam, CGA 265 and MU, expressed as thiamethoxam; and CGA 224 (CGA 224 to be included with clothianidin and considered separately from thiamethoxam). See also clothianidin. The residue is not fat-soluble. ote that thiamethoxam metabolite CGA 224 (-(2-chlorothiazol-5-ylmethyl)-'-methyl- "-nitroguanidine) will appear as clothianidin in the analytical method and residues of CGA 224 occurring in food are included in the clothianidin MRLs. Metabolite CGA 265: -(2-chlorothiazol-5-ylmethyl)-'-nitroguanidine.

212 998 Thiamethoxam Metabolite MU: amino-([(2-chlorothiazol-5-ylmethyl)-amino]-methylene)-hydrazide. Commodity THIAMETHOXAM Maximum residue level recommendations, STMR or STMR-P HR or HR-P CC ame mg/kg mg/kg mg/kg VS 62 Artichoke, Globe FI 2 Banana.2*.2.2 GC 64 Barley.4.2 AS 64 Barley straw and fodder, dry 2.9. FB 8 Berries and other small fruits VB 4 Brassica (cole or cabbage) vegetables, 5.5. Head cabbages, Flowerhead Brassicas SB 5 Cacao beans.2*.2 VS 624 Celery.2.4 FC Citrus fruits.5.. SB 6 Coffee beans.2.5 MO 5 Edible offal (Mammalian).*.. PE 2 Eggs.*.. VC 45 Fruiting vegetables, Cucurbits VO 5 Fruiting vegetables, other than Cucurbits..8.4 (except sweet corn) VL 5 Leafy vegetables.54.9 VP 6 Legume vegetables.*.. GC 645 Maize.5.2 AS 645 Maize fodder.5..4 MM 95 Meat (from mammals other than marine mammals).2. muscle. fat. muscle. fat ML 6 Milks.5.6 SO 88 Oilseed.2*.2 FI 5 Papaya.* AL 2 Pea hay or Pea fodder (dry) T 62 Pecan.*.. HS 444 Peppers Chilli, dried.8 4. FI 5 Pineapple.* FP 9 Pome fruits...5 GC 656 Popcorn.*. PM Poultry meat.*.. PO Poultry, Edible offal of.*.6.42 VD Pulses.4.2 VR 5 Root and tuber vegetables...2 FS 2 Stone fruits.95.6 VO 44 Sweet corn (corn-on-the-cob).*.. DT Tea, Green, Black (black, fermented and 2 4. dried) GC 654 Wheat.5.2 AS 654 Wheat straw and fodder, dry 2.9. Apple juice.65 Barley flour. Barley, pearled. Coffee, roasted.49 Cotton seed oil, Refined.4 Orange juice. Prunes, dried.6.5 Semolina. JF 48 Tomato juice.54 VW 448 Tomato paste.24 Tomato pulp.8 Wheat bran.2 Wheat bread.

213 Thiamethoxam 999 Commodity THIAMETHOXAM Maximum residue level recommendations, STMR or STMR-P HR or HR-P CC ame mg/kg mg/kg mg/kg Wheat flour. Wine.55 * At or about the limit of quantification. For plants and animals Definition of the residue (for compliance with the MRL and for estimation of dietary intake): CGA 224 (-(2-chlorothiazol-5-ylmethyl)- -methyl- -nitroguanidine). The residue is not fat soluble. Commodity CGA 224 Maximum residue level recommendations, STMR or STMR-P HR or HR-P CC ame mg/kg mg/kg mg/kg VS 62 Artichoke, Globe FI 2 Banana.2*.2.2 GC 64 Barley.4. AS 64 Barley straw and fodder, dry.2.5. FB 8 Berries and other small fruits...5 VB 4 Brassica (cole or cabbage) vegetables, Head cabbages, Flowerhead Brassicas SB 5 Cacao beans.2*.2 VS 624 Celery.4..2 FC Citrus fruits..2.2 SB 6 Coffee beans.5.5 MO 5 Edible offal (Mammalian), except liver.*.. PE 2 Eggs.*. AV 5 Fodder beet leaves or tops VC 45 Fruiting vegetables, Cucurbits.2*.2.2 VO 5 Fruiting vegetables, other than Cucurbits.5.2. (except sweet corn and mushrooms) VL 5 Leafy vegetables VP 6 Legume vegetables.*.. MO 99 Liver of cattle, goats, pigs and sheep.2.5. GC 645 Maize.2.2 AS 645 Maize fodder... MM 95 Meat (from mammals other than marine.*.. mammals) ML 6 Milks.2.4 SO 88 Oilseed.2.2 FI 5 Papaya.* AL 2 Pea hay or Pea fodder (dry).2.5. T 62 Pecan... HS 444 Peppers Chilli, dried.5.2. FI 5 Pineapple.* FP 9 Pome fruits GC 656 Popcorn.. PM Poultry meat.*.. PO Poultry, Edible offal of..8.5 VD Pulses.2.2 VR 5 Root and tuber vegetables.2..5 FS 2 Stone fruits VO 44 Sweet corn (corn-on-the-cob)...

214 2 Thiamethoxam Commodity CGA 224 Maximum residue level recommendations, STMR or STMR-P HR or HR-P CC ame mg/kg mg/kg mg/kg DT Tea, Green, Black (black, fermented and..2 dried) GC 654 Wheat.2.2 AS 654 Wheat straw and fodder, dry.2.5. * At or about the limit of quantification. DIETARY RISK ASSESSMET Long-term intake The International Estimated Daily Intakes of thiamethoxam, based on the STMRs estimated for 66 commodities, for the GEMS/Food regional diets were in the range of to 4% of the maximum ADI (.8 mg/kg bw) (Annex of the 2 JMPR Report). The Meeting concluded that the long-term intake of residues of thiamethoxam resulting from its uses that have been considered by JMPR is unlikely to present a public health concern. Short-term intake The International Estimated Short Term Intake (IESTI) for thiamethoxam was calculated for food commodities and their processed fractions for which maximum residue levels were estimated and for which consumption data were available. The results are shown in Annex 4 of the 2 JMPR Report. The IESTI for the general population represented 4% of the ARfD ( mg/kg bw) and the IESTI for children represented % of the ARfD. The Meeting concluded that the short-term intake of residues of thiamethoxam, when used in ways that have been considered by the JMPR, is unlikely to present a public health concern. REFERECES Author Year Title, Institute, Report references Code Adam, D 996 Degradation of C-thiazol ring labelled CGA 294 in various soils under 95DA laboratory conditions. Ciba-Geigy, Switzerland. Study 95DA. GLP. Unpublished. Adam, D 998 Paddy soil metabolism of C-thiazolring labeled CGA 294 under laboratory conditions. ovartis Crop Protection, Switzerland. Study 95DA4, Amendment. GLP. Unpublished. Adam, D Adam, D Adam, D Adams, S Adams, S 99 Paddy soil metabolism of C-thiazolring labeled CGA 294 under laboratory conditions. ovartis Crop Protection, Switzerland. Study 95DA4. GLP. Unpublished. 999 Degradation of C-thiazole labelled CGA 294 and its major metabolite CGA 224 ( C-thiazole labelled) in Borstel soil under aerobic conditions at 2 C. ovartis Crop Protection AG, Switzerland. Study 99DA. GLP. Unpublished. 999 Degradation of C-thiazole labelled CGA 224 in Schwaderloch soil under aerobic conditions at 2 C. ovartis Crop Protection AG, Switzerland. Study 99DA6. GLP. Unpublished. 998 Report on residue study IR96 (UK). Spring barley: generation of crop samples for subsequent residue analysis following seed treatment with CGA294 (A956B) in the UK. ovartis Crop Protection, UK. Study IR96. GLP. Unpublished. 998 Report on residue study IR296 (UK). Spring barley: generation of crop samples for subsequent residue analysis following seed treatment with CGA294 (A956B) in the UK. ovartis Crop Protection, UK. Study IR296. GLP. Unpublished. 95DA4 Amendment 96DA4 99DA 99DA6 IR96 IR296

215 Thiamethoxam 2 Author Year Title, Institute, Report references Code Adams, S 998 Report on residue study IR96. Spring oil seed rape: generation of grain samples IR96 for subsequent residue analysis following seed treatment with CGA 294 (A- 956B) in the UK. ovartis Crop Protection, UK. Study IR96. GLP. Unpublished. Barney, W 24 Thiamethoxam: magnitude of the residue on carrot. Syngenta. IR-4 Project, orth 468 Brunswick, USA. IR-4 study 468. GLP. Unpublished. Barney, W 24 Thiamethoxam: magnitude of the residue on radish. Syngenta. IR-4 Project, orth 6 Brunswick, USA. IR-4 study 6. GLP. Unpublished. Barney, WP 2 Thiamethoxam: magnitude of the residue on blueberry. IR-4 Project 5. Center 5 for Minor Crop Pest Management, J, USA. Field trials: -ME5, -J, - J29, -C22, -C2, -MI4, -MI5, -MI6, -OR2. GLP. Unpublished. Bell, A 25 Independent laboratory validation of a method (AG-65) for the determination of CEMR-265 residues of thiamethoxam (CGA 294) and CGA 224 in eggs. Syngenta Crop Protection, Switzerland. CEMAS, UK. Study CEMS 265. Report CEMR-265. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on grapes in France. 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on grapes in Spain. 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on grapes in Spain. 2-8 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-8. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on mandarins in Spain. 2-4 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-4. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on mandarins in Spain. 2-5 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-5. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on mandarins in Spain. 2-6 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-6. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on mandarins in Spain. 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. 2-8 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-8. GLP. Unpublished. Benazeraf, L 24 Residue study withthiamethoxam (CGA 294) in or on oranges in Spain. 2-9 Syngenta, UK. ADME Bioanalyses, France. Study 2-9. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. 2-5 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-5. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. 2-5 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-5. GLP. Unpublished. Benazeraf, L 24 Residue study with thiamethoxam (CGA 294) in or on grapes in France 2-66 (south). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study GLP. Unpublished. Boscolo P, 25 Cruiser 5 FS and Engeo Maxx magnitude of the residues of thiamethoxam, M25 Capellari eto, A and Góis Marconi, FEZ CGA224 and lambda-cyhalothrin in rice grains - Brazil, 2-4. Syngenta Proteção de Cultivos Ltda, Brazil. Study M25. GLP. Unpublished. Boxwell, C 24 Thiamethoxam (CGA 294) - validation of a residue analytical method (REM RJ59B 9_) for the determination of residues in crops (wheat grain, tomatoes, oranges and oil seed rape seed). Syngenta, United Kingdom. Report RJ59B. GLP. Unpublished. Boxwell, C 24 Validation of a residue analytical method (AG-65) for the determination of RJ5B residues in animal products (milk, eggs, meat, kidney and liver). Syngenta, United Kingdom. Report RJ5B. GLP. Unpublished. Boyette, SE 2 Magnitude of the residues in or on Crop Group C: tuberous and corm vegetables ovartis Crop Protection, USA. Study GLP. Unpublished.

216 22 Thiamethoxam Author Year Title, Institute, Report references Code Buckel, T 2 Degradation of [oxadiazin-4- C]-labelled OA 445 in soil Gartenacker under MO aerobic conditions at 2 C. Syngenta Crop Protection, Switzerland. Study MO. GLP. Unpublished. Campbel,l DD 998 CGA 294 and CGA magnitude of the residues in or on crop 5: ABR-985 Brassica (cole) leafy vegetables. ovartis Crop Protection, USA. Project ABR GLP. Unpublished. Campbel,l DD 998 CGA Magnitude of the residues in meat and milk resulting from the ABR-9852 feeding of three levels to dairy cattle. ovartis Crop Protection, USA. Project ABR exus project GLP. Unpublished. Campbell, D 2 CGA difenoconazole magnitude of the residues in or on corn. ovartis and Oakes, T Crop Protection, USA. Study GLP. Unpublished. Campbell, D 2 CGA-294 magnitude of the residues in or on sunflowers. Syngenta Crop -99 and Pyles, S Protection, USA. Study -99. GLP. Unpublished. Campbell, D 2 CGA-294 Magnitude of the residues in or on leaf lettuce. Syngenta Crop and Pyles, S Protection, USA. Study GLP. Unpublished. Campbell, DD 998 Analytical method for the determination of residues of CGA 294 and the 46 metabolite CGA 224 in animal and crop substrates by high performance liquid chromatography with detection by UV and mass spectrometry, including validation data. ovartis Crop Protection, USA. Analytical method AG-65. Project 46. GLP. Unpublished. Campbell, DD 998 CGA magnitude of the residues in or on cotton.ovartis Crop Protection 4-9 Inc, USA. Study 4-9. GLP. Unpublished. Campbell, DD 998 CGA-294 and CGA Magnitude of the residues in or on crop 4: leafy ABR-985 vegetables. ovartis Crop Protection, USA. Project ABR-985. GLP. Unpublished. Campbell, DD 998 CGA 294 and CGA magnitude of the residues on crop group : ABR-9896 pome fruits. ovartis Crop Protection, USA. Project ABR ovartis project GLP. Unpublished. Canada 2 Residue definitions for chemicals with maximum residue limits regulated under the Pest Control Products Act. Document: chemicals-residue-chimique-eng.pdf. Residue definitions as of June 2. Capps, TM 999 [Thiazol-2- C] and [oxadiazin-4- C] CGA 294: nature of the residue in 6-99 potatoes after seed treatment. ovartis Crop Protection, USA. Study GLP. Unpublished. Capps, TM 998 C-CGA-294: ature of the residue in pears. Project ABR-984. ovartis ABR-984 umber ovartis Crop Protection, USA. GLP. Unpublished. Capps, TM 999 Amendment to final report: C-CGA-294: nature of the residue in field ABR-9848 grown cucurbits. Study ABR ovartis Crop Protection, USA. Unpublished. amendment Capps, TM and 2 [Thiazol-2- C] and [oxadiazin-4- C] CGA 294: nature of the residue in 6-99 Brown, K potatoes after seed treatment. ovartis Crop Protection, USA. Study 6-99, amendment amendment. GLP. Unpublished. Carlin, TJ 998 C-CGA-294: nature of the residue in field grown cucurbits. Study ABR- ABR ovartis Crop Protection, USA. GLP. Unpublished. Chemwatch 24 itroguanidine. Australian MSDS. Material Safety Data Sheet. Chemwatch 2. Version 2. Clark, A 998 Hydrolysis of 2- C-thiazolyl CGA 294 under laboratory conditions. ovartis ABR-966 Crop Protection, USA. Report ABR-966. Study GLP. Unpublished. Corley, J 26 Thiamethoxam - magnitude of the residue on barley. IR-4 Project, orth 46 Brunswick, USA, Project 46. GLP. Unpublished. Crawford, CJ 998 Independent laboratory validation of method AG-65, for the determination of residues of CGA-294 and the metabolite CGA-224 in animal and crop substrates. ovartis Crop Protection, Switzerland. Ricerca, USA. Study CR-. Project GLP. Unpublished. Crook, SJ 24 Residue method for the determination of residues of thiamethoxam (CGA 294) REM 9.6 and CGA 224 in lettuce, tomato, grape and tobacco samples. Final Determination by LC-MS/MS. Syngenta, UK. Method REM 9.6. GLP. Unpublished. Cruz, SM 998 Metabolism of C-guanidine CGA 294 in viable and sterile clay loam soil ABR-9846 under aerobic conditions. ovartis Crop Protection, USA. Report ABR Study 8-9. GLP. Unpublished. Das, R 995 Report on melting point / melting range. Ciba-Geigy, Switzerland. Project GLP. Unpublished. Das, R 995 Report on general physico-chemical properties. Ciba-Geigy, Switzerland. Project Unpublished. Das,R 998 Report on general physico-chemical properties. ovartis Crop Protection, Switzerland. Study 582. GLP. Unpublished. 582

217 Thiamethoxam 2 Author Year Title, Institute, Report references Code de Villiers, WG 24 Thiamethoxam: residue study with thiamethoxam (A995B) in mangoes in South I 24 ZA Africa during 2/24. Syngenta South Africa. Study I 24 ZA. Field phase report. Relates to 4/9. Unpublished. de Villiers, WG 24 Thiamethoxam: residue study with thiamethoxam (A995B) in mangoes in South I 24 ZA Africa during 2/24. Syngenta South Africa. Study I 24 ZA. Field phase report. Relates to 4/8. Unpublished. Delhove, G and 25 Report on residues trials in Côte d Ivoire on papaya. COLEACP. CIV/CRA/PA/ Gerard, M CIV/CRA/PA/24. Unpublished. 24 Dixon, B 998 Aerobic soil metabolism of [ C-thiazole] CGA 294. ovartis Crop Protection, ABR-9659 USA. Study Report ABR GLP. Unpublished. Doumbia, M and Yoboue, 25 Report on residue trials in Côte d'ivoire on okra. CUECDA, Côte d'ivoire. Unpublished. CI/AIPR/24/ Kouassi Ediger, K 2 CGA-294 Magnitude of the residues in or on strawberry. Syngenta study - -. Field trials FL-IR-4-, W-IR-6-. Syngenta Crop Protection, USA. GLP. Unpublished. Ediger, K 2 CGA magnitude of the residues in or on soya bean resulting from seed 26-Feb treatment. Syngenta Crop Protection, USA. Study GLP. Unpublished. Ediger, K 2 Thiamethoxam magnitude of the residues in or on fruit, citrus, group. T Syngenta Crop Protection, USA. Report T GLP. Unpublished. Ellgehausen, H 998 Calculation of the degradation kinetics of metabolite CGA 224 in sandy soil 98EH5 Collombey. ovartis Crop Protection, Switzerland. Study 98EH5. Unpublished. Ely, SV and 24 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. - Clark,e DM Syngenta, UK. Study -. GLP. Unpublished. Ely, SV and 24 Residue study with thiamethoxam, CGA 294) in or on mandarins in Spain. - Clarke, DM Syngenta, UK. Study -. GLP. Unpublished. Ely, SV and 24 Residue study with thiamethoxam, CGA 294) in or on mandarins in Spain. - Clarke, DM Syngenta, UK. Study -. GLP. Unpublished. Ely, SV and 24 Residue study with thiamethoxam, CGA 294) in or on mandarins in Spain. -2 Clarke, DM Syngenta, UK. Study -2. GLP. Unpublished. Ely, SV and 24 Residue study with thiamethoxam, (CGA 294) in or on mandarins in Spain. - Clarke, DM Eudy, LW Eudy, LW Eudy, LW, Cobin, J and Campbell, D Franceschi, G Franceschi, G Franceschi, G Franceschi, G Francisco, E, Góis Marconi, FEZ and ascimento, F FSAZ Geoffroy, A. Giannone, C Syngenta, UK. Study -. GLP. Unpublished. 998 CGA magnitude of the residues in or on crop group 9: cucurbit vegetables. Report ABR Project 46, Study ovartis Crop Protection Inc, USA. GLP. Unpublished. 998 CGA magnitude of the residues in or on Crop Group 8: fruiting vegetables. ovartis Crop Protection, USA. Project 464. Study Report ABR-985. GLP. Unpublished. 999 CGA emamectin magnitude of the residues in or on cotton. ovartis Crop Protection, USA. Unpublished. 2 Field report. Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224 ) in bananas from Cameroon. Biological part. Syngenta study Syngenta Agro, Switzerland. Unpublished. 2 Field report. Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224 ) in bananas from Cameroon. Biological part. Syngenta study Syngenta Agro, Switzerland. Unpublished. 2 Field report. Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224 ) in bananas from Cameroon. Biological part. Syngenta study -. Syngenta Agro, Switzerland. Unpublished. 2 Field report. Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224 ) in bananas from Cameroon. Biological part. Syngenta study -2. Syngenta Agro, Switzerland. Unpublished. 22 Cruiser 5 FS + Actara 25 WG, magnitude of the residues of thiamethoxam and CGA 224 in rice, Brazil. Syngenta Proteção de Cultivos Ltda, Brazil. Study M49. GLP. Unpublished. ABR-9885 ABR M49 2 Standard.4.2Maximum Residue Limits. Food Standards Australia ew Zealand Report on vapour pressure curve. Ciba-Geigy, Switzerland. Test PP-95-5P-VPC Project GLP. Unpublished. 998 Summary of results of fortified specimens of representative plant materials and soil 5/98 analysed according to REM 9.. ovartis Crop Protection, Switzerland. Report 5/98. Unpublished.

218 24 Thiamethoxam Author Year Title, Institute, Report references Code Góis Marconi, FEZ and Casallanovo, F 29 Verdadero 6 WG and Actara 25 WG residues of thiamethoxam, CGA224 M92 and cyproconazole in coffee Brazil, -9. Syngenta Proteção de Cultivos Ltda, Brazil. Study M92. GLP. Unpublished. Góis Marconi, FEZ and Casallanovo, F Grunenwald, M and Eudy, L Hein, W and Dorn, R Higuchi, S and Matsuzawa, K Hohl, J Indergand, P and icollie,r G Indergand, P and icollier, G Joseph, TA Kang, J Kang, J Kang, J Kang, J Kato, T Kato, Y and Odanaka, Y Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M Kissling, M 29 Verdadero 2 GR and Actara GR residues of thiamethoxam, CGA224 and cyproconazole in coffee Brazil, -9. Syngenta Proteção de Cultivos Ltda, Brazil. Study M92. GLP. Unpublished. 2 Stability of CGA 294, CGA 224 and CGA 265 in meat, milk and eggs under freezer storage conditions. ovartis Crop Protection, USA. Study GLP. Unpublished. M Rate of degradation of [thiazol-2- C]-CGA 224 in Birkenheide soil. Syngenta ov- Crop Protection, Switzerland. SLFA, Germany. Study OV. GLP. Unpublished. 29 Pyroquilon and thiamethoxam (SYJ-98), azoxystrobin and thiamethoxam (YIF- 26-Jun-9 66SC) (CG-26). Crop residue analysis report, rice. Syngenta Japan. 26-Jun- 29. Unpublished. 999 Stability of residues of CGA 224 in plant material and soil stored under deep freezer conditions. ovartis Crop Protection, Switzerland. Study 2/9. GLP. Unpublished. 24 Rate of degradation of [oxadiazin-4- C] OA445 (metabolite of thiamethoxam) in various soils under aerobic laboratory conditions at 2 ºC. Syngenta Crop Protection, Switzerland. Study T22-4. GLP. Unpublished. 24 Rate of degradation of [thiazol-2- C] CGA 559 (metabolite of thiamethoxam) in various soils under aerobic laboratory conditions at 2 ºC. Syngenta Crop Protection, Switzerland. Study T2-4. GLP. Unpublished. 999 CGA and CGA 294 magnitude of the residues in or on pecans. ovartis Crop Protection, USA. Study GLP. Unpublished. 25 Thiamethoxam (CGA 294): residue study in or on protected cucumber in the etherlands. Syngenta Crop Protectio, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-26. Study CEMS-26. GLP. Unpublished. 25 Thiamethoxam (CGA 294): residue study in or on cherries in Spain. Syngenta Crop Protection, Switzerland. CEMAS, UK. Report CEMR-2. Study CEMS- 2. GLP. Unpublished. 25 Thiamethoxam (CGA 294): residue study in or on cherry in northern France. Syngenta Crop Protection, Switzerland. CEMAS, UK. Report CEMR-2. Study CEMS-2. GLP. Unpublished. 25 Thiamethoxam (CGA 294): residue study in or on cherry in Italy. Syngenta Crop Protection, Switzerland. CEMAS, UK. Report CEMR Study CEMS GLP. Unpublished. 2/9 T22-4 T CEMS-26 CEMS-2 CEMS-2 CEMS SYJ- (thiamethoxam and lufenuron). Crop residue analysis report, tea. -Jul-2 Syngenta Japan. -Jul-22. Unpublished. 998 Thiamethoxam (CG-26). Crop residue analysis report, tea. ovartis Agro. - -ov-98 ov-998. Unpublished. 998 Residue study with CGA 294 in or on potatoes in Spain. ovartis Crop 26/9 Protection, Switzerland. Study 26/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on potatoes in Spain. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. 998 Residue study with CGA 294 in or on apples in Italy. ovartis Crop Protection, 68/9 Switzerland. Study 68/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Italy. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Italy. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Italy. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Italy. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Switzerland. ovartis Crop 2/9 Protection, Switzerland. Study 2/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on tomatoes in Switzerland. ovartis Crop 22/9 Protection, Switzerland. Study 22/9. GLP. Unpublished. 998 Residue study with CGA 294 in or on potatoes in Switzerland. ovartis Crop 26/9 Protection, Switzerland. Study 26/9. GLP. Unpublished. 2 Residue study with thiamethoxam (CGA 294) in or on cocoa in Ivory Coast. / Farm: Bambaké Camara. Syngenta Crop Protection, Switzerland. Study /. Unpublished.

219 Thiamethoxam 25 Author Year Title, Institute, Report references Code Kissling, M 2 Residue study with thiamethoxam (CGA 294) in or on cocoa in Ivory Coast. 29/ Farm: Bazié Bazona. Syngenta Crop Protection, Switzerland. Study 29/. Unpublished. Kissling, M 2 Residue study with thiamethoxam (CGA 294) in or on cocoa in Ivory Coast. / Farm: Sanfo Yamba. Syngenta Crop Protection, Switzerland. Study /. Unpublished. Kissling, M 998 Residue study with CGA 294 in or on potatoes in Switzerland. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Kissling, M 2 Residue study with thiamethoxam (CGA 294) in or on cocoa in Ivory Coast. / Farm: Outtara Mamadou. Syngenta Crop Protection, Switzerland. Study /. Unpublished. Kissling, M 998 Residue study with CGA 294 in or on potatoes in France (south). ovartis /9 Crop Protection, Switzerland. Study /9. GLP. Unpublished. Kissling, M 998 Residue study with CGA 294 in or on potatoes in France (south). ovartis 2/9 Crop Protection, Switzerland. Study 2/9. GLP. Unpublished. Kissling,M 998 Residue study with CGA 294 in or on potatoes in Spain. ovartis Crop 2/9 Protection, Switzerland. Study 2/9. GLP. Unpublished. Kissling,M 998 Residue study with CGA 294 in or on apples in Italy. ovartis Crop Protection, 6/9 Switzerland. Study 6/9. GLP. Unpublished. Krainz, A 2 Residue study with thiamethoxam (CGA 294) in or on papaya in Brazil. 2-6 Syngenta, UK. RCC Ltd., Itingen, Switzerland. Syngenta study 2-6. RCC study 848. GLP. Unpublished. Krainz, A 2 Residue study with thiamethoxam (CGA 294) in or on papaya in Brazil Syngenta, UK. RCC Ltd., Itingen, Switzerland. Syngenta study RCC study GLP. Unpublished. Krainz, A 24 Residue study with thiamethoxam (CGA 294) in or on papaya in Brazil. 2-6 Syngenta, Switzerland. RCC Ltd., Itingen, Switzerland. Syngenta study 2-6. RCC study 848. GLP. Unpublished. Krainz, A 24 Residue study with thiamethoxam (CGA 294) in or on papaya in Brazil Syngenta, Switzerland. RCC Ltd., Itingen, Switzerland. Syngenta study RCC study 848. GLP. Unpublished. Krauss, J 99 Behaviour and metabolism of CGA 294 in greenhouse grown paddy rice after 95JK5PR granular application of [thiazol-2- C]-labelled material. Project 95JK5. Report 95JK5PR. ovartis Crop Protection, Switzerland. Crop metabolism report CMR 5/9. GLP. Unpublished. Krauss, J 99 Metabolism of CGA 294 in greenhouse grown paddy rice after foliar 95JK6PR application of [thiazol-2- C]-labelled material. Project 95KJK6. Report 95JK6PR. ovartis Crop Protection, Switzerland. Crop metabolism report CMR /9. GLP. Unpublished. Krauss, J 99 Behaviour and metabolism of CGA 294 in greenhouse grown paddy rice after 95JKPR granular application of [oxadiazin-4- C]-labelled material. Project 95JK. Report 95JKPR. ovartis Crop Protection, Switzerland. Crop metabolism report CMR 2/9. GLP. Unpublished. Krauss, J 99 Metabolism of CGA 294 in greenhouse grown paddy rice after foliar 95JK8PR application of [oxadiadin-4- C]-labelled material. Project 95KJK8. Report 95JK8PR. ovartis Crop Protection, Switzerland. Crop metabolism report CMR /9. GLP. Unpublished. Kravets, RR and Amos, F 2 Report of sample processing for "Thiamethoxam magnitude of the residue on plum." ovartis study ovartis trial 64.-CA96. Project MG MG68 Labuschagne, CL Labuschagne, CL Lin K and Oakes, TL Lin, K ational Food Laboratory, USA. Unpublished. 24 Thiamethoxam: residue levels in or on mangoes from a trial conducted in South Africa during 2/24. Syngenta South Africa. Study I 8 24 ZA. Field phase report. Relates to 4/4. Unpublished. 24 Thiamethoxam: residue levels in or on mangoes from a trial conducted in South Africa during 2/24. Syngenta South Africa. Study I 9 24 ZA. Field phase report. Relates to 4/4. Unpublished. 22 CGA Magnitude of the residues in meat and milk resulting from the feeding of three levels to dairy cattle. Amendment. MRID Syngenta Crop Protection, USA. Study ABR exus project GLP. Unpublished. 22 Analytical method (AG65) for the determination of residues of CGA-294 and the metabolite CGA-224 in animal and crop substrates by high performance liquid chromatography with detection by UV and mass spectrometry, including validation data, amendment. Syngenta Crop Protection, USA. Method AG-65. Study GLP. Unpublished. I 8 24 ZA I 9 24 ZA ABR Am 26-9

220 26 Thiamethoxam Author Year Title, Institute, Report references Code Lin, K 22 Thiamethoxam validation of analytical method AG-65 for the analysis of liver Syngenta Crop Protection, USA. Study GLP. Unpublished. Lin, K 998 Determination of CGA 294 by U.S. Food and Drug Administration ABR-9854 multiresidue method testing. ovartis Crop Protection, USA. Report Project ABR GLP. Unpublished. Lin, K and 22 Stability of CGA 294, CGA 224 and CGA 265 in meat, milk and eggs ABR-982 Oakes, TL under freezer storage conditions. Amendment. Syngenta Crop Protection, USA. Study ABR-982. Syngenta GLP. Unpublished. Lowery, E 99 Hydrolysis of C-guanidine-CGA 294 under laboratory conditions. ovartis ABR-9 Crop Protection, USA. Report ABR-9. Study GLP. Unpublished. Lutringer, C 998 Metabolism of [oxadiazin-4- C] CGA 294 after multiple oral administrations 2AM5 to lactating goats. ovartis Crop Protection, Switzerland. Study 2AM5. GLP. Unpublished. Lutringer, C 998 Metabolism of [oxadiazin-4- C] CGA 294 after multiple oral administrations 2AM6 to laying hens. ovartis Crop Protection, Switzerland. Study 2AM6. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Spain). Magnitude of residues after application /96 of CGA 294 as formulation WS (A-956 B) in maize. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 99 Report on residue study 2/96 (Spain). Magnitude of residues after application 2/96 of CGA 294 as formulation WS (A-956 B) in maize. ovartis Crop Protection, Switzerland. Study 2/96. GLP. Unpublished. Mair, P 99 Report on residue study 5/96 (Spain). Magnitude of residues after application 5/96 of CGA 294 as formulation WS (A-956 C) in sugarbeets. ovartis Crop Protection, Switzerland. Study 5/96. GLP. Unpublished. Mair, P 998 Residue study with thiamethoxam (CGA 294) in or on sugarbeets in the United 6/98 Kingdom. ovartis Crop Protection, Switzerland. Study 6/98. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on oranges in Spain. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 99 Report on residue study 8/96 (Spain). Magnitude of residues after application 8/96 of CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 8/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on oranges in Spain. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. Mair, P 99 Report on residue study 9/96 (Spain). Magnitude of residues after application 9/96 of CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 9/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on oranges in Spain. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Spain). Magnitude of residues after application /96 of CGA 294 as formulation 25 WG (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 99 Report on residue study 2/96 (Spain). Magnitude of residues after application 2/96 of CGA 294 as formulation 25 WG (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 2/96. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Spain). Magnitude of residues after application /96 of CGA 294 as formulation 25 WG in lemon. Ciba-Geigy Ltd, Switzerland. Study /96. GLP. Unpublished. Mair, P 99 Report on residue study 8/96 (Spain). Magnitude of residues after application 8/96 of CGA 294 as formulation 25 WG in lemon. Ciba-Geigy Ltd, Switzerland. Study 8/96. GLP. Unpublished. Mair, P 99 Report on residue study 9/96 (Spain). Magnitude of residues after application 9/96 of CGA 294 as formulation WG 25 (A-9584 C) in cotton. ovartis Crop Protection, Switzerland. Study 9/96. GLP. Unpublished. Mair, P 99 Report on residue study 2/96 (Spain). Magnitude of residues after application 2/96 of CGA 294 as formulation WG 25 (A-9584 C) in cotton. ovartis Crop Protection, Switzerland. Study 2/96. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. 2/99 ovartis Crop Protection, Switzerland. Study 2/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on oranges in Spain. 2/99 ovartis Crop Protection, Switzerland. Study 2/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on mandarins in Spain. ovartis Crop Protection, Switzerland. Study 22/99. GLP. Unpublished. 22/99

221 Thiamethoxam 2 Author Year Title, Institute, Report references Code Mair, P 999 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 25/98 metalaxyl-m (CGA 295) in or on rape in United Kingdom. ovartis Crop Protection, Switzerland. Study 25/98. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on tomatoes in Spain. 25/99 ovartis Crop Protection, Switzerland. Study 25/99. GLP. Unpublished. Mair, P 999 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 26/98 metalaxyl-m (CGA 295) in or on rape in United Kingdom. ovartis Crop Protection, Switzerland. Study 26/98. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on tomatoes in Spain. 26/99 ovartis Crop Protection, Switzerland. Study 26/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on tomatoes in France 2/99 (south). ovartis Crop Protection, Switzerland. Study 2/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on tomatoes in France /99 (south). ovartis Crop Protection, Switzerland. Study /99. GLP. Unpublished. Mair, P 99 Report on residue study 6/96 (Switzerland). Magnitude of residues after 6/96 application of CGA 294 as formulation WG 25 (A-9584C) in potatoes. ovartis Crop Protection, Switzerland. Study 6/96. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Switzerland). Magnitude of residues after /96 application of CGA 294 as formulation WG 25 (A-9584C) in potatoes. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Spain. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Switzerland). Magnitude of residues after /96 application of CGA 294 as formulation WG 25 (A-9584C) in wheat. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Spain. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 as formulation WG 25 (A-9584 C) in or on /9 tomatoes in Spain. ovartis Crop Protection, Switzerland. GLP study /9. Unpublished. Mair, P 998 Residue study with CGA 294 as formulation WG 25 (A-9584 C) in tomatoes in 2/9 Spain. ovartis Crop Protection, Switzerland. GLP study 2/9. Unpublished. Mair, P 99 Report on residue study /96 (Switzerland). Magnitude of residues after /96 application of CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on cotton seed in Spain. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 99 Report on residue study 4/96 (Switzerland). Magnitude of residues after 4/96 application of CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 4/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on cotton seed in Spain. ovartis Crop 4/9 Protection, Switzerland. Study 4/9. GLP. Unpublished. Mair, P 99 Report on residue study 5/96 (Switzerland). Magnitude of residues after 5/96 application of CGA 294 as formulation WG 25 (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 5/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on cotton seed in Spain. ovartis Crop 5/9 Protection, Switzerland. Study 5/9. GLP. Unpublished. Mair, P 99 Report on residue study 6/96 (Switzerland). Magnitude of residues after 6/96 application of CGA 294 as formulation WG 25 (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 6/96. GLP. Unpublished. Mair, P 998 Residue study with thiamethoxam (CGA 294) in or on sugarbeets in the 6/98 etherlands. ovartis Crop Protection, Switzerland. Study 6/98. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sugarbeets in Spain. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on maize in Spain. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 996 Determination of residues of CGA 294 in sugarbeets- field trial. Ciba-Geigy 5/95 Ltd, Switzerland. Study 5/95. GLP. Unpublished. Mair, P 999 Residue study with thiamethoxam (CGA 294) in or on cotton in Greece. 65/98 ovartis Crop Protection, Switzerland. Study 65/98. GLP. Unpublished. Mair, P 999 Residue study with thiamethoxam (CGA 294) in or on cotton in Greece. 66/98 ovartis Crop Protection, Switzerland. Study 66/98. GLP. Unpublished. Mair, P 99 Report on residue study 2/96 (Greece). Magnitude of residues after application 2/96 of CGA 294 as formulation WG 25 (A-9584 C) in cotton. ovartis Crop Protection, Switzerland. Study 2/96. GLP. Unpublished.

222 Thiamethoxam Author Year Title, Institute, Report references Code Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Italy. ovartis Crop 82/9 Protection, Switzerland. Study 82/9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Italy. ovartis Crop 8/9 Protection, Switzerland. Study 8/9. GLP. Unpublished. Mair, P 99 Report on residue study 85/96 (Italy). Magnitude of residues after application of 85/96 CGA 294 as formulation WS (A-956 C) in sugarbeets. ovartis Crop Protection, Switzerland. Study 85/96. GLP. Unpublished. Mair, P 99 Report on residue study 86/96 (Italy). Magnitude of residues after application of 86/96 CGA 294 as formulation WS (A-956 C) in sugarbeets. ovartis Crop Protection, Switzerland. Study 86/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sugarbeets in Italy. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sugarbeets in Italy. ovartis Crop 92/9 Protection, Switzerland. Study 92/9. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on sweet peppers in France 92/99 (south). ovartis Crop Protection, Switzerland. Study 92/99. GLP. Unpublished. Mair, P 99 Report on residue study 9/96 (Italy). Magnitude of residues after application of 9/96 CGA 294 as formulation 25 WG (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 9/96. GLP. Unpublished. Mair, P 99 Report on residue study 94/96 (Italy). Magnitude of residues after application of 94/96 CGA 294 as formulation 25 WG (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 94/96. GLP. Unpublished. Mair, P 99 Report on residue study 95/96 (Italy). Magnitude of residues after application of 95/96 CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 95/96. GLP. Unpublished. Mair, P 99 Report on residue study 96/96 (Italy). Magnitude of residues after application of 96/96 CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 96/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on cotton seed in Greece. ovartis Crop 96/9 Protection, Switzerland. Study 96/9. GLP. Unpublished. Mair, P 99 Report on residue study 9/96 (Italy). Magnitude of residues after application of 9/96 CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 98/96. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on cotton seed in Greece. ovartis Crop 9/9 Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 99 Report on residue study 98/96 (Italy). Magnitude of residues after application of 98/96 CGA 294 as formulation WG 25 (A-9584 C) in tomatoes. ovartis Crop Protection, Switzerland. Study 98/96. GLP. Unpublished. Mair, P 99 Report on residue study 99/96 (Italy). Magnitude of residues after application of 99/96 CGA 294 as formulation WG 25 (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study 99/96. GLP. Unpublished. Mair, P 99 Report on residue study /96 (Italy). Magnitude of residues after application of /96 CGA 294 as formulation WG 25 (A-9584 C) in sweet peppers. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Mair, P 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and /98 metalaxyl-m (CGA 295) in or on rape in France (south). ovartis Crop Protection, Switzerland. Study /98. GLP. Unpublished. Mair, P 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 2/98 metalaxyl-m (CGA 295) in or on rape in France (south). ovartis Crop Protection, Switzerland. Study 2/98. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on eggplant in Switzerland. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and /98 metalaxyl-m (CGA 295) in or on rape in France (south). ovartis Crop Protection, Switzerland. Study /98. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on eggplant in Switzerland. ovartis Crop /9 Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on eggplant in Switzerland. ovartis Crop 5/9 Protection, Switzerland. Study 5/9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Switzerland. ovartis 6/9 Crop Protection, Switzerland. Study 6/9. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Switzerland. ovartis /9 Crop Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. ovartis Crop Protection, Switzerland. Study /99. GLP. Unpublished. /99

223 Thiamethoxam 29 Author Year Title, Institute, Report references Code Mair, P 998 Residue study with CGA 294 in or on sweet peppers in Switzerland. ovartis 8/9 Crop Protection, Switzerland. Study 8/9. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. 8/99 ovartis Crop Protection, Switzerland. Study 8/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. 9/99 ovartis Crop Protection, Switzerland. Study 9/99. GLP. Unpublished. Mair, P 998 Stability of residues of CGA 294 in plant material under deep freezer 2/96 conditions. ovartis Crop Protection, Switzerland. Study 2/96. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. 2/99 ovartis Crop Protection, Switzerland. Study 2/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on potatoes in Spain. 25/99 ovartis Crop Protection, Switzerland. Study 25/99. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on wheat in Switzerland. ovartis Crop 2/9 Protection, Switzerland. Study 2/9. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on cotton in Greece. 4/99 ovartis Crop Protection, Switzerland. Study 4/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on cotton in Greece. 5/99 ovartis Crop Protection, Switzerland. Study 5/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. 6/99 ovartis Crop Protection, Switzerland. Study 6/99. GLP. Unpublished. Mair, P 996 Report on residue study /95. CGA 294, oranges, Spain. Determination of /95 residues of CGA 294 in oranges (, pulp, peel) field trial. Ciba- Geigy Ltd, Switzerland. Study /95. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on lemons in Spain. /99 ovartis Crop Protection, Switzerland. Study /99. GLP. Unpublished. Mair, P 996 Report on residue study 8/95. CGA 294, oranges, Spain. Determination of 8/95 residues of CGA 294 in oranges (, pulp, peel) field trial. Ciba- Geigy Ltd, Switzerland. Study 8/95. GLP. Unpublished. Mair, P 996 Report on residue study 9/95. CGA 294, oranges, Spain. Determination of 9/95 residues of CGA 294 in oranges (, pulp, peel, juice) field trial. Ciba-Geigy Ltd, Switzerland. Study 9/95. GLP. Unpublished. Mair, P 996 Report on residue study /95. CGA 294, oranges, Spain. Determination of /95 residues of CGA 294 in oranges (, pulp, peel, juice) field trial. Ciba-Geigy Ltd, Switzerland. Study /95. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on sweet peppers in Spain. 2/99 ovartis Crop Protection, Switzerland. Study 2/99. GLP. Unpublished. Mair, P 2 Residue study with thiamethoxam (CGA 294) in or on sweet peppers in Spain. /99 ovartis Crop Protection, Switzerland. Study /99. GLP. Unpublished. Mair, P 998 Residue study with CGA 294 in or on tomatoes in Spain. ovartis Crop 69/9 Protection, Switzerland. Study 69/9. GLP. Unpublished. Mair, P 999 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 6/9 metalaxyl-m (CGA 95) in or on rape in France (north). ovartis Crop Protection, Switzerland. Study 6/9. GLP. Unpublished. Mair, P 999 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and /9 metalaxyl-m (CGA 95) in or on rape in France (north). ovartis Crop Protection, Switzerland. Study /9. GLP. Unpublished. Mair, P 999 Residue Study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 8/9 metalaxyl-m (CGA 95) in or on rape in France (south). ovartis Crop Protection, Switzerland. Study 8/9. GLP. Unpublished. Mair, P 999 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294) and 9/9 metalaxyl-m (CGA 95) in or on rape in France (south). ovartis Crop Protection, Switzerland. Study 9/9. GLP. Unpublished. Mair, P 998 Analysis on CGA 294 in potatoes. ovartis Crop Protection, Switzerland. 8/9 Study gr Analytical report 8/9. GLP. Unpublished. Mair, P 998 Analysis on CGA 294 in potatoes. ovartis Crop Protection, Switzerland. 8/9 Study gr 649. Analytical report 8/9. GLP. Unpublished. Mair, P 995 Determination of CGA 294 by HPLC, plant material. Ciba-Geigy Ltd., REM 9. Switzerland. Method REM 9.. Unpublished. Mair, P 998 Determination of CGA 294 and CGA 224 by HPLC. ovartis Crop REM 9. Protection, Switzerland. Method REM 9.. Unpublished. Mair,P 99 Report on residue study /96 (Greece). Magnitude of residues after application /96 of CGA 294 as formulation WG 25 (A-9584 C) in cotton. ovartis Crop Protection, Switzerland. Study /96. GLP. Unpublished. Moore, M and Ediger, K 2 Thiamethoxam: magnitude of the residues on plum. IR-4 project 64. Syngenta studyr Syngenta Crop Protection, USA. GLP. Unpublished. 64

224 2 Thiamethoxam and Iwatani, M 998. Unpublished. oegrohati, Sri 29 Estimation of national MRL for thiamethoxam in oranges (Citrus nobilis). Trial 82/SPKS/PPK-PPI/V/29. Center of Permit and Investment. Department of Agriculture, Jakarta, Indonesia and Gadjah Mada University, Jogyakarta, Indonesia. Unpublished. Oakes, T, Eudy, L and Vincent, T Oakes, TL and Ediger, K Oakes, TL and Eudy, LW 22 CGA-294 magnitude of the residues in or on Crop Group 8: fruiting vegetables amendment. Syngenta Crop Protection, USA. Study 9-. GLP. Unpublished. 2 CGA Magnitude of the residues in or on crop group : pome fruits. Syngenta Crop Protection, USA. Study 5-. GLP. Unpublished. 2 CGA 294 magnitude of the residues in or on crop group 5: Brassica (cole) leafy vegetables. Syngenta study 2-. Syngenta Crop Protection, USA. GLP. Unpublished. Author Year Title, Institute, Report references Code Moore, ME and 2 Thiamethoxam: magnitude of the residues on peach. Syngenta study IR Ediger, K project 52. Syngenta Crop Protection, USA. GLP. Unpublished. Moore, ME and 2 Thiamethoxam: magnitude of the residues on cherry. Syngenta study 6-. IR-4 6 Ediger, K project 6.Syngenta Crop Protection, USA. GLP. Unpublished. 6- Morris, I 25 The determination of imidacloprid in fruit and vegetables by LC-MS. Standard PRES/64 Operating Procedure. PRES/64. Unpublished. Müller, T and 996 Absorption, distribution, and excretion of [thiazol-2- C] and [oxadiazin-4- C] 2AM Stampf, P CGA 294 in the rat. Ciba-Geigy Ltd, Switzerland. Report /96. Project 2AM. GLP. Unpublished. akanishi, J 998 Thiamethoxam (CG-26). Crop residue analysis report, tea. ovartis Agro. -Jul- -Jul-98 82/SPKS/PPK- PPI/V/ Oakes, TL and 2 CGA-294 magnitude of the residues in or on Crop Group 4: leafy vegetables. 22- Eudy, LW Syngenta Crop Protection, USA. Study 22-. GLP. Unpublished. Odanaka, Y and 22 Lufenuron and thiamethoxam (SYJ-). Crop residue analysis report, tea. 26-Dec-2 Wakasone, Y Syngenta Japan. 26-Dec-22. Unpublished. Oliver-Kang, J 26 Thiamethoxam (CGA 294): residue study in or on protected cucumber in CEMS-2 Spain. Syngenta Crop Protection, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-2. Study CEMS-2. GLP. Unpublished. Oliver-Kang, J 2 Thiamethoxam (CGA 294):residue study in or on cherries in Switzerland. Syngenta Crop Protection, Switzerland. CEMAS, UK. Report CEMR-229. Study CEMS-229. GLP. Unpublished. Osborne, V Osborne, V Pelz, S and Steinhauer, S Phaff, R Pointurier,R Pointurier,R Pointurier, R Pointurier, R Pointurier, R Pointurier, R Pointurier, R 22 Residue Study with thiamethoxam (CGA 294) in or on grapes in Italy. Syngenta, UK. Study /. GLP. Unpublished. 22 Residue study with thiamethoxam (CGA 294) in or on grapes in Spain. Syngenta, UK. Study 65/. GLP. Unpublished. 2 Validation of the DFG Method S9 (extended revision) for the determination of residues of thiamethoxam (CGA 294) in/on rape (seed). Syngenta Crop Protection, Switzerland. Dr. Specht & Partner, Germany. Report SY-V. GLP. Unpublished. 99 Rate of degradation of CGA 294 in soil under various conditions. ovartis Crop Protection, Switzerland. Study 95RP. GLP. Unpublished. 999 Residue study with CGA CGA 56 + CGA 694 in or on winter wheat in north of France. ADME Bioanalyses, France. Study 984. GLP. Unpublished. 999 Residue study with CGA 294 in or on maize in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. 22 Residue study with thiamethoxam (CGA 294) in or on grapes in France (north). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study. GLP. Unpublished. 22 Residue study with thiamethoxam (CGA 294) in or on grapes in France (south). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2. GLP. Unpublished. 22 Residue study with thiamethoxam (CGA 294) in or on grapes in France (south). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 52. GLP. Unpublished. 998 Report on residue study: 95, France, north. Magnitude of residues of CGA 294 and CGA 224 in apples and processed food after application of formulation A9584C WG 25. ovartis Agro, France. Study 95. GLP. Unpublished. 998 Report on residue study: 9, France, south. Magnitude of residues of CGA 294 and CGA 224 in wheat after application of formulation A9584C. ovartis Agro, France. Study 9. GLP. Unpublished. CEMS-229 / 65/ SY-V 95RP

225 Thiamethoxam 2 Author Year Title, Institute, Report references Code Pointurier, R 998 Report on residue study: 92, France, south. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A9584C. ovartis Agro, France. Study 92. GLP. Unpublished. Pointurier, R 998 Report on residue study: 9, France, south. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A9584C. ovartis Agro, France. Study 9. GLP. Unpublished. Pointurier, R 998 Report on residue study 98, France, north. Magnitude of residues of 98 CGA 294 and CGA 224 in wheat after application of formulation A9584C. Dissipation study. ovartis Crop Protection, France. Study 98. GLP. Unpublished. Pointurier, R 998 Report on residue study: 982, France, south. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A9584C. Dissipation study. ovartis Agro, France. Study 982. GLP. Unpublished. Pointurier, R 998 Report on residue study: 98, France, south. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A9584C WG 25. Dissipation study. ovartis Agro, France. Study 98. GLP. Unpublished. Pointurier, R 998 Report on residue study: 984, France, south. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A9584C WG 25. Dissipation study. ovartis Agro, France. Study 984. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on spring wheat in north of France. ADME 99 Bioanalyses, France. Study 99. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on spring wheat in north of France. ADME 992 Bioanalyses, France. Study 992. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on spring wheat in south of France. ADME 99 Bioanalyses, France. Study 99. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on spring wheat in south of France. ADME 994 Bioanalyses, France. Study 994. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on potatoes in south of France. ADME 95 Bioanalyses, France. Study 95. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on potatoes in south of France. ADME 952 Bioanalyses, France. Study 952. GLP. Unpublished. Pointurier, R 998 Residue study with CGA 294 in or on potatoes in south of France. ADME 95 Bioanalyses, France. Study 95. GLP. Unpublished. Pointurier, R 998 Report on residue study: 945, France, north. Magnitude of residues of CGA and CGA 224 in peas dry (whole plant, dry seeds and haulm) after application of formulation A956B WS on peas seeds. ovartis Agro, France. Study 945. GLP. Unpublished. Pointurier, R 998 Report on residue study: 9454, France, south. Magnitude of residues of CGA and CGA 224 in peas dry (whole plant, dry seeds and haulm) after application of formulation A956B WS on peas seeds. ovartis Agro, France. Study GLP. Unpublished. Pointurier, R 998 Report on residue study: 9455, France, south. Magnitude of residues of CGA and CGA 224 in peas dry (whole plant, dry seeds and haulm) after application of formulation A956B WS on peas seeds. ovartis Agro, France. Study GLP. Unpublished. Pointurier, R 998 Report on residue study: 9456, France, south. Magnitude of residues of CGA and CGA 224 in peas dry (whole plant, dry seeds and haulm) after application of formulation A956B WS on peas seeds. ovartis Agro, France. Study GLP. Unpublished. Pointurier, R 99 Report on residue study: 946 France, north. Magnitude of residues of CGA and CGA 224 after application of formulation A956B WS : seed treatment. ovartis Agro S.A., France. Study 946. GLP. Unpublished. Pointurier, R 998 Report on residue study: 9462 France, north. Magnitude of residues of CGA and CGA 224 in sugarbeet after application of formulation A956B WS : seed treatment. ovartis Agro S.A., France. Study GLP. Unpublished. Pointurier, R 99 Report on residue study: 946 France, south. Magnitude of residues of CGA and CGA 224 in sugar beet after application of formulation A956B WS : seed treatment. ovartis Agro S.A., France. Study 946. GLP. Unpublished. Pointurier, R 998 Report on residue study: 94 France, south. Magnitude of residues of CGA 294 and CGA 224 in spring wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study 94. GLP. Unpublished. 94

226 22 Thiamethoxam Author Year Title, Institute, Report references Code Pointurier, R 998 Report on residue study: 942 France, south. Magnitude of residues of CGA and CGA 224 in spring wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study 942. GLP. Unpublished. Pointurier, R 998 Report on residue study: 94 France, south. Magnitude of residues of CGA and CGA 224 in spring wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study 94. GLP. Unpublished. Pointurier, R 998 Report on residue study: 94, France, south. Magnitude of residues of CGA and CGA 224 in maize after application of formulation A956B WS on maize seeds. ADME Bioanalyses, France. Study 94. GLP. Unpublished. Pointurier, R 998 Report on residue study: 942, France, south. Magnitude of residues of CGA and CGA 224 in maize after application of formulation A956B WS on maize seeds. ADME Bioanalyses, France. Study 942. GLP. Unpublished. Pointurier, R 998 Report on residue study: 942, France, south. Magnitude of residues of CGA and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study 942. GLP. Unpublished. Pointurier, R 998 Report on residue study: 94 France, north. Magnitude of residues of CGA and CGA 224 in wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study 94. GLP. Unpublished. Pointurier, R 998 Report on residue study: 94 France, south. Magnitude of residues of CGA and CGA 224 in spring barley after application of formulation A956B WS on barley seeds. ADME Bioanalyses, France. Study 94. GLP. Unpublished. Pointurier, R 998 Report on residue study: 942 France, south. Magnitude of residues of CGA and CGA 224 in spring barley after application of formulation A956B WS on barley seeds. ADME Bioanalyses, France. Study 942. GLP. Unpublished. Pointurier, R 998 Report on residue study: 946, France, north. Magnitude of residues of CGA and CGA 224 in maize after application of formulation A956B WS on maize seeds. ADME Bioanalyses, France. Study 946. GLP. Unpublished. Pointurier, R 998 Report on residue study: 9462, France, north. Magnitude of residues of CGA and CGA 224 in maize after application of formulation A956B WS on maize seeds. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA CGA 56 + CGA 694 in or on winter 9842 wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA CGA 56 + CGA tefluthrin in or 9844 on winter wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA CGA 56 + CGA tefluthrin in or on winter wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA CGA 56 + CGA tefluthrin in or 9844 on winter wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA CGA 56 + CGA tefluthrin in or on winter wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA tefluthrin in or 9845 on spring wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA tefluthrin in or on spring wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA tefluthrin in or 9845 on spring wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA tefluthrin in or on spring wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA 694 in or on spring wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. 9846

227 Thiamethoxam 2 Author Year Title, Institute, Report references Code Pointurier, R 2 Residue study with CGA CGA 56 + CGA 694 in or on spring wheat in north of France. ADME Bioanalyses, France Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA 694 in or on spring 9846 wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA 694 in or on spring wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA flutriafol in or 984 on spring barley in north of France. ADME Bioanalyses, France. Study 984. GLP. Unpublished. Pointurier, R 2 Residue Study with CGA CGA 56 + CGA flutriafol in or 9842 on spring barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA flutriafol in or 9848 on spring barley in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA CGA 56 + CGA flutriafol in or on spring barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA 294 in or on peas in north of France. ADME 9849 Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA 294 in or on peas in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 999 Residue study with CGA 294 in or on peas in north of France. ADME 984 Bioanalyses, France. Study 984. GLP. Unpublished. Pointurier, R 999 Residue study with CGA 294 in or on maize in north of France. ovartis Crop 984 Protection, Switzerland. ADME Bioanalyses, France. Study 984. GLP. Unpublished. Pointurier, R 999 Residue study with CGA 294 in or on maize in south of France. ADME 9845 Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil in or on wheat in north of France ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil in or on wheat in south of France ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole + tefluthrine in or 994 on wheat in north of France. ADME Bioanalyses, France. Study 994. GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole + teflutrine in or 9942 on wheat in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole + teflutrine in or 994 on wheat in south of France. ADME Bioanalyses, France. Study 994. GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole + teflutrine in or 9944 on wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole in or on wheat in 9944 south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + difenoconazole in or on wheat in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + cyprodinil + flutriafol in or on 9945 winter barley in north of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + cyprodinil + flutriafol in or on 9946 winter barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + cyprodinil + flutriafol in or on winter barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with CGA fludioxonil + cyprodinil + flutriafol in or on winter barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. 9946

228 2 Thiamethoxam Author Year Title, Institute, Report references Code Pointurier, R 2 Residue study with CGA fludioxonil + cyprodinil + flutriafol in or on winter barley in south of France. ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), cyprodinil (CGA 294), 9948 thiamethoxam (CGA 294) and flutriafol (ASF 56) in or on spring barley in France (north). ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), cyprodinil (CGA 294), thiamethoxam (CGA 294) and flutriafol (ASF 56) in or on spring barley in France (north). ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294), and 994 metalxyl-m (CGA 295) in or on maize in France (north). ADME Bioanalyses, France. Study 994. GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294), and 9942 metalaxyl-m (CGA 295) in or on maize in France (south). ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294), and 9942 metalxyl-m (CGA 295) in or on maize in France (north). ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 2 Residue study with fludioxonil (CGA 56), thiamethoxam (CGA 294), and metalxyl-m (CGA 295) in or on maize in France (south). ADME Bioanalyses, France. Study GLP. Unpublished. Pointurier, R 99 Report on residue study OI96, France, south. Magnitude of residues of OI96 CGA 294 and CGA 224 in wheat after application of formulation A9584C. ovartis Agro, France. Study OI96. GLP. Unpublished. Pointurier, R 99 Report on residue study OI964 trial AC2, France, south. Magnitude of residues OI964/AC2 of CGA 294 and CGA 224 in wheat after application of formulation A9584C. Dissipation study. ovartis Agro, France. Study OI964/AC2. GLP. Unpublished. Pointurier, R 99 Report on residue study: OI964, trial KJ6, France, north. Magnitude of residues OI964/KJ6 of CGA 294 and CGA 224 in wheat after application of formulation A9584C. Dissipation study. ovartis Agro, France. Study OI964/KJ6. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial AC2, France, south. Magnitude of OS964/AC2 residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/AC2. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial AC2, France, south. Magnitude of OS964/AC2 residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/AC2. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial FP, France, south. Magnitude of OS964/FP residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/FP. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial KJ95, France, north. Magnitude of OS964/KJ95 residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/KJ95. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial LD99, France, south. Magnitude of OS964/LD99 residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/LD99. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964, trial SJ5, France, north. Magnitude of OS964/SJ5 residues of CGA 294 and CGA 224 in protein peas after application of formulation A956B on protein pea seeds. ovartis Agro, France. Study OS964/SJ5. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9642 trial AC France, south. Magnitude of residues OS9642/AC of CGA 294 and CGA 224 after application of formulation A956B on barley seeds. ovartis Agro, France. Study OS9642/AC. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9642 trial LD98 France, south. Magnitude of residues OS9642/LD98 of CGA 294 and CGA 224 after application of formulation A956B on barley seeds. ovartis Agro, France. Study OS9642/LD98. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS9642 trial SJ6 France, north. Magnitude of residues OS9642/SJ6 of CGA 294 and CGA 224 after application of formulation A956B on barley seeds. ovartis Agro, France. Study OS9642/SJ6. GLP. Unpublished.

229 Thiamethoxam 25 Author Year Title, Institute, Report references Code Pointurier, R 99 Report on residue study: OS964 trial AC6 France, south. Magnitude of residues OS964/AC6 of CGA 294 and CGA 224 after application of formulation A956B on wheat seeds. ovartis Agro S.A., France. Study OS964/AC6. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964 trial SJ France, north. Magnitude of residues OS964/SJ of CGA 294 and CGA 224 after application of formulation A956B on wheat seeds. ovartis Agro S.A., France. Study OS964/SJ. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9645 trial AC4, France, south. Magnitude of OS9645/AC4 residues of CGA 294 and CGA 224 after application of formulation A956B on rape seeds. ovartis Agro, France. Study OS9645/AC4. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9645 trial AC5, France, south. Magnitude of OS9645/AC5 residues of CGA 294 and CGA 224 after application of formulation A956B on rape seeds. ovartis Agro, France. Study OS9645/AC5. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9645 trial FP2, France, south. Magnitude of residues OS9645/FP2 of CGA 294 and CGA 224 after application of formulation A956B on rape seeds. ovartis Agro, France. Study OS9645/FP2. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9645 trial KJ94, France north. Magnitude of residues OS9645/KJ94 of CGA 294 and CGA 224 after application of formulation A956B on rape seeds. ovartis Agro, France. Study OS9645/KJ94. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9646, trial AC8, France, south. Magnitude of OS9646/AC8 residues of CGA 294 and CGA 224 in maize after application of formulation A956B on maize seeds. ovartis Agro, France. Study OS9646/ AC8. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9646, trial KJ92, France, north. Magnitude of OS9646/KJ92 residues of CGA 294 and CGA 224 in maize after application of formulation A956B on maize seeds. ovartis Agro, France. Study OS9646/KJ92. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9646, trial LD95, France, south. Magnitude of OS9646/LD95 residues of CGA 294 and CGA 224 in maize after application of formulation A956B on maize seeds. ovartis Agro, France. Study OS9646/LD95. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS9646, trial SJ9, France, north. Magnitude of OS9646/SJ9 residues of CGA 294 and CGA 224 in maize after application of formulation A956B on maize seeds. ovartis Agro, France. Study OS9646/SJ9. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964 trial AC France, south. Magnitude of residues OS964 AC of CGA 294 and CGA 224 after application of formulation A956B on beet seeds. ovartis Agro S.A., France. Study OS964. GLP. Unpublished. Pointurier, R 99 Magnitude of residues of CGA 294 and CGA 224 after application of OS964/DE2 formulation A956B on beet seeds. ovartis Agro S.A., France. Study OS964/DE2. GLP. Unpublished. Pointurier, R 99 Report on residue study: OS964 trial KJ9 France, north. Magnitude of residues OS964/KJ9 of CGA 294 and CGA 224 after application of formulation A956B on beet seeds. ovartis Agro S.A., France. Study OS964/KJ9. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS942 trial AC98 France, south. Magnitude of residues OS942/AC98 of CGA 294 and CGA 224 in wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study OS942/AC98. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS942 trial KJ2 France, north. Magnitude of residues OS942/KJ2 of CGA 294 and CGA 224 in wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study OS942/KJ2. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS942 trial LD France, south. Magnitude of residues OS942/LD of CGA 294 and CGA 224 in wheat after application of formulation A956B WS on wheat seeds. ovartis Agro S.A., France. Study OS942/LD. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS94 trial AC9 France, south. Magnitude of residues OS94/AC9 of CGA 294 and CGA 224 in barley after application of formulation A956B WS on barley seeds. ovartis Agro, France. Study OS94/AC9. GLP. Unpublished.

230 26 Thiamethoxam Author Year Title, Institute, Report references Code Pointurier, R 998 Report on residue study: OS94 trial KJ France, north. Magnitude of residues OS94/KJ of CGA 294 and CGA 224 in barley after application of formulation A956B WS on barley seeds. ovartis Agro, France. Study OS94/KJ. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS94 trial LD2 France, south. Magnitude of residues OS94/LD2 of CGA 294 and CGA 224 in barley after application of formulation A956B WS on barley seeds. ovartis Agro, France. Study OS94/LD2. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS944 trial AC95, France, south. Magnitude of OS944/AC95 residues of CGA 294 and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study OS944/AC95. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS944 trial AC96, France, south. Magnitude of OS944/AC96 residues of CGA 294 and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study OS944/AC96. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS944, trial KJ4, France, north. Magnitude of OS944/KJ4 residues of CGA 294 and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study OS944/KJ4. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS944 trial LD, France, south. Magnitude of OS944/LD residues of CGA 294 and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study OS944/LD. GLP. Unpublished. Pointurier, R 998 Report on residue study: OS944 trial LD4, France, south. Magnitude of OS944/LD4 residues of CGA 294 and CGA 224 in rape grains after application of formulation A956B WS (seed treatment). ovartis Agro, France. Study OS944/LD4. GLP. Unpublished. Pointurier,R 998 Report on residue study: 945, France, south. Magnitude of residues of CGA and CGA 224 in peas dry (whole plant, dry seeds and haulm) after application of formulation A956B WS on peas seeds. ovartis Agro, France. Study 945. GLP. Unpublished. Rawle, 24 Residue study with thiamethoxam (CGA 294) in or on protected cucumbers in -2 Spain. Syngenta Crop Protection, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-22 Version 2. Study -2. GLP. Unpublished. Rawle, 24 Residue study with thiamethoxam (CGA 294) in or on protected cucumbers in -22 Spain. Syngenta Crop Protection, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-224. Study -22. GLP. Unpublished. Rawle, 25 Residue study with thiamethoxam (CGA 294) in or on protected melons in -2 Spain. Syngenta Crop Protection, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-225 Study -2. GLP. Unpublished. Rawle, 25 Residue study with thiamethoxam (CGA 294) in or on protected melons in -24 Spain. Syngenta Crop Protection, Switzerland. CEMAS, orth Ascot, UK. Report CEMR-226 Study -24. GLP. Unpublished. Rawle, 24 Independent laboratory validation of a method (REM 9.) for the determination CEMR-22 of residues of thiamethoxam (CGA 294) and CGA 224 in tomatoes and cereal grain. Study CEMS-22. Report CEMR-22. CEMAS, UK. GLP. Unpublished. Rawle, 24 Independent laboratory validation of a method (AG 65) for the determination of CEMR-2 residues of thiamethoxam (CGA 294) and CGA 224 in milk, meat and liver. Syngenta Crop Protection, Switzerland. CEMAS, UK. Study CEMS2. Report CEMR-2. GLP. Unpublished. Roncato, C 2 Actara 25 WG residues of thiamethoxan and CGA 224 in pinapple after M4 complete treatment on thiamethoxam basis - Brazil, Syngenta Proteção de Cultivos Ltd.a, São Paulo, Brazil. Study M4. GLP. Unpublished. Rümbeli, R 998 Metabolism of [thiazol-2- C] CGA 294 after multiple oral administrations to 2AM lactating goats. ovartis Crop Protection, Switzerland Study 2AM. GLP. Unpublished. Rümbeli, R 998 Metabolism of [thiazol-2- C] CGA 294 after multiple oral administrations to 2AM4 laying hens. ovartis Crop Protection, Switzerland. Study 2AM4. GLP. Unpublished. Sandmeier, P 996 Uptake, distribution and degradation of CGA 294 in field grown corn after seed 95PSA4PR treatment with [oxadiazin-4- C] labelled material. Project 95PSA4. Report 95PSA4PR. Ciba-Geigy, Switzerland. Plant metabolism report PMR /96. GLP. Unpublished.

231 Thiamethoxam 2 Author Year Title, Institute, Report references Code Sandmeier, P 99 Metabolism of [oxadiazin-4- C]CGA 294 in corn. Project 95PSA4. Report 95PSA4PR2 95PSA4PR2. ovartis Crop Protection, Switzerland. Crop metabolism report CMR /9. GLP. Unpublished. Sandmeier, P 996 Uptake, distribution and degradation of CGA 294 in field grown corn after seed 95PSA4PR treatment with [thiazol-2- C] labelled material. Project 95PSA4. Report 95PSA4PR. Ciba-Geigy, Switzerland. Plant metabolism report PMR 6/96. GLP. Unpublished. Sandmeier, P 99 Metabolism of [thiazol-2- C]CGA 294 in corn. Project 95PSA4. Report 95PSA4PR2 95PSA4PR2. ovartis Crop Protection, Switzerland. Crop metabolism report CMR 9/9. GLP. Unpublished. Sandmeier, P 99 Outdoor confined accumulation study on rotational crops after bareground 95PSA42PR application of [oxadiazin-4- C]CGA 294. ovartis Crop Protection AG, Switzerland. Crop metabolism report CMR 2/9. Project report 95PSA42PR. GLP. Unpublished. Sandmeier, P 99 Outdoor confined accumulation study on rotational crops after bareground 95PSA4PR application of [thiazol-2- C]CGA 294. ovartis Crop Protection, Switzerland. Crop metabolism report CMR 6/9. Project report 95PSA4PR. GLP. Unpublished. Sandmeier, P 999 Metabolism of [thiazol-2- C] and [oxadiazin-4- C] CGA 294 in field grown 99PSA52 lettuce. ovartis Crop Protection, Switzerland. Study 99PSA52. GLP. Unpublished. Satter, P 2 Residue study with thiamethoxam (CGA 294) in or on cucumbers in Spain. 2- Syngenta Crop Protection, Switzerland. Study 2-. GLP. Unpublished. Satter, P 2 Residue study with thiamethoxam (CGA 294) in or on tomatoes in Spain. 2-2 Syngenta Crop Protection, Switzerland. Study 2-2. GLP. Unpublished. Satter, P 22 Residue study with thiamethoxam (CGA 294) in or on bananas in Cameroon Report on analytical part for non-glp Study Syngenta Crop Protection AG, Switzerland. ot GLP. Unpublished. Satter, P 22 Residue study with thiamethoxam (CGA 294) in or on grapes in Switzerland. / Syngenta Crop Protection, Switzerland. Study /. GLP. Unpublished. Satter, P 22 Residue study with thiamethoxam (CGA 294) in or on grapes in Switzerland. / Syngenta Crop Protection, Switzerland Study /. GLP. Unpublished. Satter,P 2 Residue study with thiamethoxam (CGA 294) in or on sweet peppers in Spain. 2-2 Syngenta Crop Protection, Switzerland. Study 2-2. GLP. Unpublished. Schwartz, B 998 Final report: aerobic soil metabolism of [ C-guanidine] CGA 294. ovartis ABR-9684 Crop Protection, USA. Study Report ABR GLP. Unpublished. Schwartz, B 998 Photodegradation of C-thiazolyl-CGA 294 in ph 5 buffered solution under ABR-989 artificial light. ovartis Crop Protection, USA. Report ABR-989. Study GLP. Unpublished. Smith,JA 998 Determination of residues of CGA294 and the metabolite CGA224 in gr 689 spring wheat. ovartis Agro, Germany. Report gr 689. GLP. Unpublished. Smith, JA 2 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in winter oilseed rape. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 99 Residues of CGA294 in spring wheat. ovartis Agro, Germany. Study gr gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 6229 potatoes. ovartis Agro, Germany. Report gr GLP. Unpublished. Smith, JA 2 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in winter oilseed rape. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 99 Residues of CGA294 in spring barley. ovartis Agro, Germany. Study gr gr GLP. Unpublished. Smith, JA 99 Residues of CGA 294 in maize (test product: CGD 6I - A956B). ovartis gr 6296 Agro, Germany. Study gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 649 potatoes. ovartis Agro, Germany. Report gr 649. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 6449 spring wheat, soil and processing products (semolina, bran, flour and bread). ovartis Agro GmbH, Germany. Study gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 659 spring wheat, soil and processing products (semolina, bran, flour and bread). ovartis Agro GmbH, Germany. Study gr 659. GLP. Unpublished. Smith, JA 99 Residues of CGA 294 in spring oilseed rape (test product: CGD 6 I - A956B). ovartis Agro, Germany. Study gr GLP. Unpublished. gr 65496

232 Thiamethoxam Author Year Title, Institute, Report references Code Smith, JA 999 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in spring oilseed rape. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 999 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in spring oilseed rape. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 99 Residues of CGA 294 in spring oilseed rape (test product: CGD 6 I - gr A956B). ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 999 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in spring oilseed rape. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 2 Determination of residues of CGA 294 and the metabolite CGA 224, CGA gr and CGA 56 in spring oilseed rape. ovartis Agro, Germany. Study gr 99. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 49 peas. ovartis Agro, Germany. Study gr 49. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 529 peas. ovartis Agro, Germany. Study gr 529. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 69 peas. ovartis Agro, Germany. Study gr 69. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 29 peas. ovartis Agro, Germany. Study gr 29. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 89 maize. ovartis Agro, Germany. Study gr 89. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 829 maize. ovartis Agro, Germany. Study gr 829. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 8249 maize. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 89 maize. ovartis Agro, Germany. Study gr 89. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 8429 maize. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 6298 sugar beet. ovartis Agro GmbH, Germany. Report gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 6998 sugar beet. ovartis Agro GmbH, Germany. Report gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA294 and the metabolite CGA294 in gr 6949 spring barley. ovartis Agro, Germany. Study gr GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 29 spring oilseed rape. ovartis Agro, Germany. Study gr 29. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 29 spring oilseed rape. ovartis Agro, Germany. Study gr 29. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 829 sugar beet. ovartis Agro GmbH, Germany. Report gr 829. GLP. Unpublished. Smith, JA 998 Determination of residues of CGA 294 and the metabolite CGA 224 in gr 949 sugar beet. ovartis Agro GmbH, Germany. Report gr 949. GLP. Unpublished. Solé,C 24 Residue study with thiamethoxam (CGA 294) in or on melons in Spain. 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on grapes in Switzerland. 2-6 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-6. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on grapes in Switzerland. 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on cucumbers in Spain. 2-8 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-8. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on melons in Spain. 2-9 Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-9. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on melons in Italy. Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. 2-

233 Thiamethoxam 29 Author Year Title, Institute, Report references Code Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on cucumbers in France 2- (north). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on grapes in France (north). 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Solé, C 24 Residue study with thiamethoxam (CGA 294) in or on grapes in France (north). 2- Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-. GLP. Unpublished. Solé, C 2 Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224) in 2-69 bananas from Cameroon. Syngenta Crop Protection AG, Switzerland. ADME Bioanalyses, France. Study ot GLP. Unpublished. Solé, C 2 Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224) in - bananas from Cameroon. Syngenta Crop Protection AG, Switzerland. ADME Bioanalyses, France. Study -. ot GLP. Unpublished. Solé, C 2 Residues of thiamethoxam (CGA 294) and its metabolite (CGA 224) in -2 bananas from Cameroon. Syngenta Crop Protection AG, Switzerland. ADME Bioanalyses, France. Study -2. ot GLP. Unpublished. Solé, C 26 Thiamethoxam (CGA 294) - residue study on cherries in Switzerland. Syngenta 5-46 Crop Protection, Switzerland. ADME Bioanalyses, France. Study GLP. Unpublished. Solé, C 2 Thiamethoxam (CGA 294) - residue study on cherries in France (north) Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study GLP. Unpublished. Solé, C 2 Thiamethoxam (CGA 294) - Residue study on cherries in Spain and France 5-4 (south). Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 5-4. GLP. Unpublished. Solé, C 26 Thiamethoxam (CGA 294) - Residue study on cherries in Italy. Syngenta Crop 5-56 Protection, Switzerland. ADME Bioanalyses, France. Study GLP. Unpublished. Solé, C 2 Thiamethoxam (CGA 294) Residue study on cherries in northern France in 26. Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Report T64-6-REG. GLP. Unpublished. Solé, C Solé, C Solé, C Solé, C Solé,C Sparrow, K Sparrow, K Sparrow, K Starner,VR Starner, V Starner, V Starner, VR 2 Thiamethoxam (CGA 294) Residue study on cherries in Southern France in 26. Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Report T642-6-REG. GLP. Unpublished. 2 Thiamethoxam (CGA294) residue study on grapes and processed products in Switzerland and northern France in 26. ADME Bioanalyses, France. Study T9-6. Report SY/RES/-26. GLP. Unpublished. 2 Thiamethoxam (CGA294) residue study on grapes and processed products in southern France in 26. ADME Bioanalyses, France. Study T98-6. Report SY/RES/-2. GLP. Unpublished. 2 Thiamethoxam (CGA 294): residue study on field tomato in Spain and Italy in 26. Syngenta, UK. ADME Bioanalyses, France, Study T8-6. Report SY/RES/6-6. GLP. Unpublished. 24 Residue study with thiamethoxam (CGA 294) in or on melons in Italy. Syngenta Crop Protection, Switzerland. ADME Bioanalyses, France. Study 2-6. GLP. Unpublished. 99 Photodegradation of C-[thiazolyl]-CGA 294 on soil under artificial light. ovartis Crop Protection, USA. Report ABR-9. Study GLP. Unpublished. 99 Photodegradation of C-[guanidine]-CGA 294 on soil under artificial light. ovartis Crop Protection, USA. Report ABR-92. Study GLP. Unpublished. 99 Photodegradation of C-guanidine-CGA 294 in ph 5 buffered solution under artificial light. ovartis Crop Protection, USA. Report ABR-92. Study GLP. Unpublished. 2 Thiamethoxam: magnitude of the residue on cranberry. IR-4 Project 54. Center for Minor Crop Pest Management, J, USA. Field trials: -MA, -J, - WI8, -WI9, -OR9, -OR2. GLP. Unpublished. T64-6- REG T REG T9-6 T98-6 T ABR-9 ABR-92 ABR Thiamethoxam: magnitude of the residue on artichoke. IR-4 project 82. orth 82 Brunswick, USA. GLP. Unpublished. 26 Thiamethoxam - magnitude of the residue on hops. IR-4 Project, orth Brunswick, 845 USA. Project 845. GLP. Unpublished. 22 Thiamethoxam: magnitude of the residue on bean (succulent). Syngenta. IR Project, orth Brunswick, USA. IR-4 study 589. GLP. Unpublished.

234 22 Thiamethoxam Author Year Title, Institute, Report references Code Starner, VR 2 Thiamethoxam: magnitude of the residue on pea (dry). Syngenta. IR-4 Project, 59 orth Brunswick, USA. IR-4 study 59. GLP. Unpublished. Starner, VR 2 Thiamethoxam: magnitude of the residue on bean (dry). Syngenta. IR-4 Project, 65 orth Brunswick, USA. IR-4 study 65. GLP. Unpublished. Starner, VR 2 Thiamethoxam: magnitude of the residue on pea (succulent). Syngenta. IR-4 66 Project, orth Brunswick, USA. IR-4 study 66. GLP. Unpublished. Starner, VR 26 Thiamethoxam - magnitude of the residue on caneberry. IR-4 Project Center for Minor Crop Pest Management, J, USA. Field trials: 2-J, 2- OR8, 2-OR9, 2-WA, 2-CA6, 2-MI2. GLP. Unpublished. Stulz, J 995 Report on water solubility. Ciba-Geigy, Switzerland. Project GLP Unpublished. Stulz, J 995 Report on octanol/water partition coefficient. Ciba-Geigy, Switzerland. Project GLP. Unpublished. Stulz, J 995 Report on dissociation constant in water. Ciba-Geigy, Switzerland. Project GLP. Unpublished. Stulz, J 998 Report on solubility in organic solvents. ovartis Crop Protection, Switzerland Study GLP. Unpublished. Tack, T 998 Report on residue study IR96. Determination of residues in potatoes after IR96 application of CGA 294, formulated as A-9584 C, as a foliar treatment. ovartis Crop Protection, UK. Study IR96. GLP. Unpublished. Tack, T 998 Report on residue study IR96. Determination of residues in potatoes after IR96 application of CGA 294, formulated as A-9584 C, as a foliar treatment. ovartis Crop Protection, UK. Study IR96. GLP. Unpublished. Tack, TJ 998 Report on residue study IR 996. (UK Study) Peas: generation of crop samples for IR996 subsequent residue analysis following seed treatment with A-956B. ovartis Crop Protection, UK. Study IR996. GLP. Unpublished. Tauber, R and 999 Independent laboratory validation of ovartis Method AG-65: Analytical method McLean, for the determination of residues CGA 294 and the metabolite CGA 224 in animal and crop substrates by high performance liquid chromatography. ovartis Crop Protection, USA. Study GLP. Unpublished. Thanei, P 998 The metabolism of [thiazol-2- C] and [oxadiazin-4- C] CGA 294 in the rat. 2AM2 ovartis Crop Protection, Switzerland. Study 2AM2. GLP. Unpublished. Tribolet, R 998 Validation of analytical method REM 9. for the determination of CGA 294 /98 and CGA 224 in crops by HPLC using field grown pears after treatment with C-labelled CGA 294. ovartis Crop Protection, Switzerland. Report /98. GLP. Unpublished. Ulbrich, R 999 Hydrolysis of C-labelled CGA 224 under laboratory conditions. ovartis 98UL Crop Protection, Switzerland. Study 98UL. GLP. Unpublished. Ulbrich, R 998 Hydrolysis of C-labelled CGA 294 under processing conditions. ovartis 98UL5 Crop Protection, Switzerland. Study 98UL5. GLP. Unpublished. van Zyl, PFC 25 Determination of thiamethoxam residues in mangoes. SABS, Pretoria, South 4/8 Africa, Syngenta SA, Johannesburg, South Africa. Study 4/8. Report 2/2/Y8. GLP. Unpublished. van Zyl, PFC 25 Determination of thiamethoxam residues in mangoes. SABS, Pretoria, South 4/9 Africa, Syngenta SA, Johannesburg, South Africa, Study 4/9. Report 2/2/Y9. GLP. Unpublished. van Zyl, PFC 25 Determination of thiamethoxam residues in mangoes. SABS, Pretoria, South 4/4 Africa, Syngenta SA, Johannesburg, South Africa. Study 4/4. Report 2/26/Y4. GLP. Unpublished. van Zyl, PFC 25 Determination of thiamethoxam residues in mangoes. SABS, Pretoria, South 4/4 Africa, Syngenta SA, Johannesburg, South Africa. Study 4/4. Report 2/2/Y4. GLP. Unpublished. Walser, M 99 Applicability of multiresidue method DFG S 9 for determination of parent 5/9 compound CGA 294 and metabolite CGA 224 in potatoes, wheat grains and rape seeds. ovartis Crop Protection, Switzerland. Study 5/9. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in winter oil seed rape after ov-9 application of CGA 294 as formulation A-956B in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR9. Dr. Specht & Partner, Germany. Project OV-989. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in spring oil seed rape after application of CGA 294 as formulation A-956B in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR29. Dr. Specht & Partner, Germany. Project OV-982. GLP. Unpublished. ov-2

235 Thiamethoxam 22 Author Year Title, Institute, Report references Code Weber, H 998 Residue study of CGA294 and CGA224 in winter wheat after an ov-2 application of CGA294 as formulation A956B in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR9. Dr. Specht & Partner, Germany. Project OV-982. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in winter wheat after an ov-22 application of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR9. Dr. Specht & Partner, Germany. Project OV GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in winter wheat after an ov-2 application of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR29. Dr. Specht & Partner, Germany. Project OV-982. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in winter wheat after an ov-24 application of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR9. Dr. Specht & Partner, Germany. Project OV GLP. Unpublished. Weber, H 998 Residue study of CGA294 and CGA224 in winter barley after an ov-25 application of CGA294 as formulation A956B in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR49. Dr. Specht & Partner, Germany. Project OV GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in potatoes and processed ov- products after four applications of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR9. Dr. Specht & Partner, Germany. Project OV-98. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in egg plants grown in ov-6 greenhouses after two applications of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR29. Dr. Specht & Partner, Germany. Project OV-986. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in sweet peppers grown in ov- greenhouses after two applications of CGA 294 as formulation A-9584C in Great Britain, 99. ovartis Crop Protection, Switzerland. Study IR29. Dr. Specht & Partner, Germany. Project OV-98. GLP. Unpublished. Weber, H 998 Residue study of CGA 294 and CGA 224 in vining pea after an application ov-8 of CGA 294 as formulation A-956B in Denmark, 996. ovartis Crop Protection, Switzerland. Study IR96. Dr. Specht & Partner, Germany. Project OV-988. GLP. Unpublished. Whetton, M no Direct Laboratories: final analytical report for the analysis of pesticide residues in 6/22 date samples of okra. COLE/ACP Ref: (PIP o. 6/22/Direct-Lab/) and (PIP o. 6/22/Direct-Lab/5). Field trials and pesticides residue monitoring on Okra in Ivory Coast. Unpublished. Wood A 2 Compendium of Pesticide Common ames.