Education Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium

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1 Affiliations Machine Learning Group (MLG), Département d Informatique Faculté des Sciences, Université Libre de Bruxelles. Boulevard du Triomphe CP 212, 1050 Brussels, Belgium. Artificial Intelligence lab (AI- lab), Vakgroep Computerwetenschappen, Faculteit Wetenschappen, Vrije Universiteit Brussel. Pleinlaan 2, 1050 Brussels, Belgium. Tel ; Fax [email protected] or [email protected] Education Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium (10/ /2003) PhD in Computer Science (May 2003), Greatest Distinction Dissertation title: Different selection levels in artificial evolutionary systems: analysis and simulation of selection dynamics. Supervisor: Professor Bernard Manderick Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium (10/ /1996) Master in Applied Computer Science, Great Distinction Dissertation title: Design patterns and adaptive systems: a pattern language for genetic algorithm encoding. Supervisors: Professor Theo D Hondt and Professor Bernard Manderick Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium (10/ /1994) Bachelor in Computer Science (one year program) Sint- Lodewijk Instituut (currently called Karel de Grote Hogeschool), Nationalestraat 5, 2000 Antwerp. Belgium. (10/ /1993) Graduate in Applied Computer Science, Distinction. Prizes and awards First Summer school on Computational Intelligence. Limerick, Ireland (2001). «Most Innovative paper award» for Raising the dead; extending evolutionary algorithms with a case- based memory. ESTOOLS International Scientific Symposium on stem cells in biology and disease. Gulbenkian Foundation, Lisbon, Portugal (2010) «2e poster prize» (from ~250 posters) for Stochastic elimination of cancer stem cells in patients with chronic myeloid leukemia. European Conference on Computational Biology (ECCB). Ghent, Belgium. (2010) «3e poster prize» (from ~420 posters), Fitness differences as an explanation for differences between chronic myeloid leukemia therapies. Employment Département d Informatique, Faculté des Sciences, Université Libre de Bruxelles (10/ ) Chargé de Cours (Associate Professor), fulltime Member of the Machine Learning group, performing Computational

2 Biology and Game Theory research. Vrije Universiteit Brussel (10/ /2013) Onderzoeksprofessor (Research professor), 10% Member of the Artificial Intelligence group and collaborator of the Molecular Recognition group, performing research into intra- domain communication patterns and allostery in collaboration with Prof. Nico van Nuland. VIB Switch laboratory, Faculteit Wetenschappen, Vrije Universiteit Brussel, (03/ /2008) Postdoctoral researcher, fulltime Performing structural bioinformatics research. Vrije Universiteit Brussel (10/ /2006) Assistant professor, 20% Member of the Computational Modeling lab, teaching courses on Artificial Intelligence related subjects. IRIDIA, Faculté des Science Appliqués, Université Libre de Bruxelles, (10/ /2006) Postdoctoral researcher and interim assistant, fulltime. Computational modeling of chemical systems, complex networks analysis and evolutionary game theory research. Vrije Universiteit Brussel (10/ /2003) PhD student and Postdoctoral researcher (EU funded), fulltime Member of the Artificial Intelligence lab, research in the evolution of language. Vrije Universiteit Brussel (10/ /2002) Teaching assistant and PhD student, fulltime Member of the Adaptive Systems group, research in the evolutionary computation and machine learning. Funding De Bits en Bytes van Eiwitcommunicatie VUB Horizontal research action ( ) Role Co- PI (collaboration with Prof. Frederic Rousseau (SWITCH) and Prof. Luc Steels (ARTI) at the Vrije Universiteit Brussel). The in Silico wet lab IRSIB (Belgium, Brussels region) ICT projet ( ) Role Co- PI (collaboration with Prof. Hugues Bersini (IRIDIA, ULB), Prof. Vincent Detours (IRIBHM, ULB) and Prof. Ann Nowé (COMO, VUB.) The bits and bytes of protein communication FWO funded (Belgium, Flemish Community) research project ( ) Role PI Inference of the Structural Signaling networks for SH3 FNRS funded (Belgium, French Community), Crédit aux Chercheurs (2009) Role PI Unravelling the information processing patterns of SH2 domains participating in the JAK/STAT pathway FNRS funded (Belgium, French Community) project FRFC ( ) Role PI (Collaboration with Dr. Stefan Constantinescu,

3 Signal Transduction & Molecular Hematology de Duve Institute UCL) Preference dynamics in adaptive networks FNRS funded (Belgium, French Community) project FRFC ( ) Role Co- PI (collaboration with Prof. G. Kirchsteiger (ECARES, ULB) Press Research interests Teaching experience De Morgen (news paper) «Mensen zijn zo homogeen als gist», written by Tina De Gendt. (EGO- bijlage p.27), March 3, 2006 Knack (general magazine) «Misbruiken of misbruikt worden», written by Dirk Draulans. March 8, «Samen voor ons Eigen», written by Dirk Draulans. January 3, «Egoïsten de pas afsnijden», written by Dirk Draulans. February 25, «De valkuilen van een klimaatconferentie», written by Dirk Draulans. June 23, 2012 : EOS Magazine (scientific magazine) «Waarom mensen samenwerken», written by Cathy Rigolle. April 2006 De Frente, (Portugese news paper) «A tentação de atraiçoar o próximo représenta». May 1, Le Soir (news paper) «L Imatinib effectif contre la leucémie» written by Frederic Soumois. February, ATHENA review (general magazine). «Leucémie, nouveaux progress». March, Belgian Oncology news (scientific magazine). «Un modèle de LMC confirme les résultats de l imatinib» «Model voor CML bevestigt resultaten met imatinib» written by Dr. Michelle Cooreman. February /March, (Evolutionary) Game Theory, Computational Biology, Computational Intelligence Introduction à la Bioinformatique (INFO- F- 208) Second year Bachelors Computer Science, Faculty of Sciences, Université Libre de Bruxelles, Brussels, Belgium. 5 ECTS (2-1- 2), Learning Dynamics (INFO- F- 409) First year Master in Computer Science, Faculty of Sciences and Applied Sciences, Université Libre de Bruxelles and Vrije Universiteit Brussel, Brussels, Belgium. 5 ECTS (2-1- 2), Projet BA3 (INFO- F- 308) Third year Bachelor in Computer Science, Faculty of Sciences and Applied Sciences, Université Libre de Bruxelles, Brussels, Belgium. 5 ECTS (0-0- 5) Applications en bioinformatique et modélisation - Projet de conception et de réalisation d un logiciel de bioinformatique ou de modélisation (INFO- F- 435) First year Master in Bioinformatics and Modelling, Faculty of Sciences, Université Libre de Bruxelles, Brussels, Belgium. 5 ECTS (1-0- 4)

4 Bioinformatics (WE- DINF and INFO- Y- 051). Optional cours in the Master of Computer Science, Vrije Universiteit Brussels and Université Libre de Bruxelles, Brussels, Belgium. 6 ECTS (2-1- 3) Artificial Intelligence I (VUB13173). Second year Bachelor in Computer Science, Vrije Universiteit Brussels, Brussels, Belgium. (26 hours) Algorithms and Data Structures 1, Bachelor in Computer Science, «begeleidingsonderwijs» (evening courses). Vrije Universiteit Brussels, Brussels, Belgium. (30 hours) Promoter Master student dissertations Vrije Universiteit Brussel: , 10 dissertations, topics including co- evolutionary algorithms, multi- objective optimization, evolutionary game theory, chemical simulations, structural bioinformatics, cellular dynamics Université Libre de Bruxelles: , 4 dissertations topics including evolutionary game theory, complex networks and reciprocity. PhD jury member External to ULB and VUB 5 (University of Southampton, Université de Lausanne, Norwegian University of Science and Technology, KU Leuven- KULAK, Universidad Carlos III de Madrid) Internal to ULB or VUB 17 (Computer Science, Computer Engineering, Molecular Biology, Bioengineering) PhD supervisor Five most A. Defaweux. Evolutionary Transitions as a Metaphor for Compositional Search: Definition and evaluation of a new optimization algorithm. April Department of Computer Science, Faculty of Sciences, Vrije Universiteit Brussel. F. Santos. Topological Evolution: from biological to social networks. May In collaboration with Prof. H. Bersini (ULB) and Prof. J.M Pacheco (University of Lisbon, Portugal), Faculty of Applied Sciences. Université Libre de Bruxelles. S. Van Segbroeck. Adaptive networks and evolutionary game theory. April In collaboration with Prof. Jorge M. Pacheco (University of Braga, Portugal) and Prof. Ann Nowé (VUB). Computer Science Department, Faculty of Sciences,Vrije Universiteit Brussel. R. Huculeci. NMR Relaxtion experiments to analyse long- range communication inside domains and tandem domains. Started May 2009, In collaboration with Prof. N. Van Nuland. L.R. Fernandez. Quantifying structural information processing within the tyrosine phosphatase SHP2 under normal and disease conditions.. Started February 2010, in collaboration with Prof. N. Van Nuland. I. Zisis. Preference dynamics in adaptive networks. Started, May 2012, in collaboration with Prof. G. Kirchsteiger (ECARES, ULB). 1. F. Santos, J.M. Pacheco and T. Lenaerts. (2006) Evolutionary dynamics of social dilemmas in structured heterogeneous

5 important publications Publications overview Conference organization and track chair Editor proceedings and journals Tom LENAERTS populations. Proceedings of the National Academy of Science USA. 103 (9): (Corresponding author) 2. F. Santos, J.M Pacheco and T. Lenaerts. (2006) Cooperation prevails when individuals adjust their social ties. PLoS Computational Biology 2(10):e140 doi: / journal.pcbi (Corresponding author) 3. T. Lenaerts, J. Ferkinghoff- Borg, F. Stricher, L. Serrano, J. Schymkowitz and F. Rousseau (2008) Quantifying information transfer by protein domains: Analysis of the Fyn SH2 domain structure. BMC Structural Biology 8:43 (First author) 4. T. Lenaerts, J.M. Pacheco, A. Traulsen and D. Dingli (2010) Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without hitting leukemic stem cells. Haematologica 95(6): (First author) 5. T. Lenaerts, F. Castagnetti, A. Traulsen, J.M. Pacheco, G. Rosti and D. Dingli (2011) Explaining the in vivo and in vitro differences in leukemia therapy. Cell Cycle 10(10): (First author) Book chapters Journals Conferences Abstracts h- index 13 Num. cit March 2001, The Second Belgian/Dutch workshop for PhD students on Evolutionary Algorithms (BEAD), Belgium December 2002 Workshop on Dynamical Hierarchies organized during ALIFE8. Sydney, Australia January 2004 The Annual Machine Learning conference for Belgium and the Netherlands (BENELEARN), Belgium July Genetic and evolutionary computation conference (GECCO). Program chair for GA- track. Montréal, Canada. August 2011, European conference on Artificial Life (ECAL). Program chair. Paris, France. September 2012, European Conference on Complex Systems (ECCS). Local track chair Biological Complexity, Brussels, Belgium. Artificial Life journal : 11(4) and 14(3) Proceedings of «11th European Conference on Artificial Life» (ECAL2011). MIT Press Proceedings GA track of the «Genetic and evolutionary computing conference» (GECCO2009), ACM press