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1 Report date: 4/4/0 Case file ID: 0 Date of Birth: 0/0/970 Maternal Age at EDD: 0 Gestational Age: 8 weeks/6 days Additional Reports Sent to: Samples Collected: //0 LOW RISK for Trisomies, 8,, and and Triploidy. Trisomy /0 (0.%) </0,000 (<0.0%) Trisomy 8 /,4 (0.09%) </0,000 (<0.0%) Trisomy /,49 (0.0%) </0,000 (<0.0%) /568 (0.8%) </0,000 (<0.0%) Triploidy/Vanishing twins Based on a priori and test results T T8 T HI GH RI SK LOW RI SK X </0,000 (<0.0%) /500 (0.% ) / 00 ( % ) ensure good quality data for accurate, consistent results. s indicating 9,500 loci using a targeted PCR assay, and sequenced using an Illumina HiSeq T CI:[9.5%-00%] CI:[99.5%-00%] T8 CI:[78.%-00%] CI:[99.5%-00%] copy number for chromosomes, 8,, X and Y, thereby identifying T CI:[59.0%-00%] CI:[99.5%-00%] any whole chromosome abnormali9% CI:[6.5%-99.8%] CI:[99.5%-00%] Triploidy/ Vanishing CI:[47.8%-00%] Twins placental mosaicism 0/ 00 ( 0% ) >99/00 () for aneuploidy of chromosomes, 8,, X and Y only. Abnormalities Due to inability to distinguish between vanishing twins and triploidy, specificity cannot be calculated. References: Snijders RJ, et al. Maternal age- and gestation-specific for trisomy. Ultrasound Obstet Gynecol 999 Mar;(): Snijders etal. Maternal age and gestational age specific for chromosomal defects. Fetal Dign Ther 995 Nov-Dec:0(6): Gravholt CH, et al. Prenatal and postnatal prevalence of Turner syndrome: a registry study. BMJ 996; :6-. Levy B, et al. Use of targeted sequencing of SNPs to achieve highly accurate non-invasive detection of fetal aneuploidy of chromosomes, 8,, and sex chromosomes in Society of Maternal Fetal Medicine(San Francisco 0). Zimmerman B, et al. Noninvasive prenatal aneuploidy testing of chromosomes, 8,, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn 0 Dec; ():-4. IF THE ORDERING PROVIDER HAS QUESTIONS OR WISHES TO DISCUSS THE, PLEASE CONTACT US AT AND ASK FOR THE GENETIC COUNSELOR ON CALL. CLIA ID#05D0899 Natera, Inc., NIPT (6478) 0 Industrial Road Suite 40, San Carlos, CA 94070
2 Report date: 4/4/0 Case file ID: 0 Date of Birth: 0/0/970 Maternal Age at EDD: 0 Gestational Age: 8 weeks/6 days Additional Reports Sent to: Samples Collected: //0 s are consistent with a possible triploid or vanishing twin pregnancy. Follow-up counseling and testing is recommended. Although these results increase the for a triploid fetus, the possibility of a vanishing twin pregnancy (or unrecognized multiple gestation) cannot be excluded. Review of clinical history along with ultrasound findings and possible diagnostic prenatal testing is recommended to fully interpret results. SEX OF FETUS: Trisomy /9 (0.44%) Trisomy 8 /465 (0.%) Trisomy /,48 (0.07%) /55 (0.9%) Increased Follow up counseling and testing recommended Triploidy/Vanishing twins ensure good quality data for accurate, consistent results. s indicating 9,500 loci using a targeted PCR assay, and sequenced using an Illumina HiSeq T CI:[9.5%-00%] CI:[99.5%-00%] T8 CI:[78.%-00%] CI:[99.5%-00%] copy number for chromosomes, 8,, X and Y, thereby identifying T CI:[59.0%-00%] CI:[99.5%-00%] any whole chromosome abnormali9% CI:[6.5%-99.8%] CI:[99.5%-00%] Triploidy/ Vanishing CI:[47.8%-00%] Twins placental mosaicism Based on a priori and test results for aneuploidy of chromosomes, 8,, X and Y only. Abnormalities Due to inability to distinguish between vanishing twins and triploidy, specificity cannot be calculated. References: Snijders RJ, et al. Maternal age- and gestation-specific for trisomy. Ultrasound Obstet Gynecol 999 Mar;(): Snijders etal. Maternal age and gestational age specific for chromosomal defects. Fetal Dign Ther 995 Nov-Dec:0(6): Gravholt CH, et al. Prenatal and postnatal prevalence of Turner syndrome: a registry study. BMJ 996; :6-. Levy B, et al. Use of targeted sequencing of SNPs to achieve highly accurate non-invasive detection of fetal aneuploidy of chromosomes, 8,, and sex chromosomes in Society of Maternal Fetal Medicine(San Francisco 0). Zimmerman B, et al. Noninvasive prenatal aneuploidy testing of chromosomes, 8,, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn 0 Dec; ():-4. IF THE ORDERING PROVIDER HAS QUESTIONS OR WISHES TO DISCUSS THE, PLEASE CONTACT US AT AND ASK FOR THE GENETIC COUNSELOR ON CALL. CLIA ID#05D0899 Natera, Inc., NIPT (6478) 0 Industrial Road Suite 40, San Carlos, CA 94070
3 Report date: 4/4/0 Case file ID: 0 Date of Birth: 0/0/970 Maternal Age at EDD: 0 Gestational Age: 8 weeks/6 days Additional Reports Sent to: Samples Collected: //0 LOW RISK for Trisomies, 8, and, and. Trisomy /0 (0.%) </0,000 (<0.0%) Trisomy 8 /,4 (0.09%) </0,000 (<0.0%) Trisomy /,49 (0.0%) </0,000 (<0.0%) /568 (0.8%) </0,000 (<0.0%) Based on a priori and test results T T8 T HI GH RI SK LOW RI SK X </0,000 (<0.0%) /500 (0.% ) / 00 ( % ) ensure good quality data for accurate, consistent results. s indicating 9,500 loci using a targeted PCR assay, and sequenced using an Illumina HiSeq T CI:[9.5%-00%] CI:[99.5%-00%] T8 CI:[78.%-00%] CI:[99.5%-00%] copy number for chromosomes, 8,, X and Y, thereby identifying T CI:[59.0%-00%] CI:[99.5%-00%] any whole chromosome abnormali9% CI:[6.5%-99.8%] CI:[99.5%-00%] 0/ 00 ( 0% ) >99/00 () for aneuploidy of chromosomes, 8,, X and Y only. Abnormalities References: Snijders RJ, et al. Maternal age- and gestation-specific for trisomy. Ultrasound Obstet Gynecol 999 Mar;(): Snijders etal. Maternal age and gestational age specific for chromosomal defects. Fetal Dign Ther 995 Nov-Dec:0(6): Gravholt CH, et al. Prenatal and postnatal prevalence of Turner syndrome: a registry study. BMJ 996; :6-. Levy B, et al. Use of targeted sequencing of SNPs to achieve highly accurate non-invasive detection of fetal aneuploidy of chromosomes, 8,, and sex chromosomes in Society of Maternal Fetal Medicine(San Francisco 0). Zimmerman B, et al. Noninvasive prenatal aneuploidy testing of chromosomes, 8,, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn 0 Dec; ():-4. IF THE ORDERING PROVIDER HAS QUESTIONS OR WISHES TO DISCUSS THE, PLEASE CONTACT US AT AND ASK FOR THE GENETIC COUNSELOR ON CALL. CLIA ID#05D0899 Natera, Inc., NIPT (6478) 0 Industrial Road Suite 40, San Carlos, CA 94070
4 Report date: 4/4/0 Case file ID: 0 Date of Birth: 0/0/970 Maternal Age at EDD: 0 Gestational Age: 8 weeks/6 days Additional Reports Sent to: Samples Collected: //0 Unable to report due to uninformative DNA pattern. Redraw is not recommended. Reasons for uninformative DNA pattern can include: higher than expected levels of homozygosity (i.e.haploblocks) that affect the test bioinformatics, multiple gestations, vanishing twins, triploidy, clarity of maternal SNP profile, or use of egg donors and/or surrogates Trisomy /9 (0.44%) Trisomy 8 /465 (0.%) Trisomy /,48 (0.07%) /55 (0.9%) ensure good quality data for accurate, consistent results. s indicating 9,500 loci using a targeted PCR assay, and sequenced using an Illumina HiSeq T CI:[9.5%-00%] CI:[99.5%-00%] T8 CI:[78.%-00%] CI:[99.5%-00%] copy number for chromosomes, 8,, X and Y, thereby identifying T CI:[59.0%-00%] CI:[99.5%-00%] any whole chromosome abnormali9% CI:[6.5%-99.8%] CI:[99.5%-00%] Based on a priori and test results for aneuploidy of chromosomes, 8,, X and Y only. Abnormalities References: Snijders RJ, et al. Maternal age- and gestation-specific for trisomy. Ultrasound Obstet Gynecol 999 Mar;(): Snijders etal. Maternal age and gestational age specific for chromosomal defects. Fetal Dign Ther 995 Nov-Dec:0(6): Gravholt CH, et al. Prenatal and postnatal prevalence of Turner syndrome: a registry study. BMJ 996; :6-. Levy B, et al. Use of targeted sequencing of SNPs to achieve highly accurate non-invasive detection of fetal aneuploidy of chromosomes, 8,, and sex chromosomes in Society of Maternal Fetal Medicine(San Francisco 0). Zimmerman B, et al. Noninvasive prenatal aneuploidy testing of chromosomes, 8,, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn 0 Dec; ():-4. IF THE ORDERING PROVIDER HAS QUESTIONS OR WISHES TO DISCUSS THE, PLEASE CONTACT US AT AND ASK FOR THE GENETIC COUNSELOR ON CALL. CLIA ID#05D0899 Natera, Inc., NIPT (6478) 0 Industrial Road Suite 40, San Carlos, CA 94070
5 Report date: 4/4/0 Case file ID: 0 Date of Birth: 0/0/970 Maternal Age at EDD: 0 Gestational Age: 8 weeks/6 days Additional Reports Sent to: Samples Collected: //0 Unable to report due to low fetal fraction. Submission of a new sample is required for testing. Trisomy /9 (0.44%) Trisomy 8 /465 (0.%) Trisomy /,48 (0.07%) /55 (0.9%) ensure good quality data for accurate, consistent results. s indicating 9,500 loci using a targeted PCR assay, and sequenced using an Illumina HiSeq T CI:[9.5%-00%] CI:[99.5%-00%] T8 CI:[78.%-00%] CI:[99.5%-00%] copy number for chromosomes, 8,, X and Y, thereby identifying T CI:[59.0%-00%] CI:[99.5%-00%] any whole chromosome abnormali9% CI:[6.5%-99.8%] CI:[99.5%-00%] SEX OF FETUS: Fetal fraction: Based on a priori and test results for aneuploidy of chromosomes, 8,, X and Y only. Abnormalities References: Snijders RJ, et al. Maternal age- and gestation-specific for trisomy. Ultrasound Obstet Gynecol 999 Mar;(): Snijders etal. Maternal age and gestational age specific for chromosomal defects. Fetal Dign Ther 995 Nov-Dec:0(6): Gravholt CH, et al. Prenatal and postnatal prevalence of Turner syndrome: a registry study. BMJ 996; :6-. Levy B, et al. Use of targeted sequencing of SNPs to achieve highly accurate non-invasive detection of fetal aneuploidy of chromosomes, 8,, and sex chromosomes in Society of Maternal Fetal Medicine(San Francisco 0). Zimmerman B, et al. Noninvasive prenatal aneuploidy testing of chromosomes, 8,, X, and Y, using targeted sequencing of polymorphic loci. Prenat Diagn 0 Dec; ():-4. IF THE ORDERING PROVIDER HAS QUESTIONS OR WISHES TO DISCUSS THE, PLEASE CONTACT US AT AND ASK FOR THE GENETIC COUNSELOR ON CALL. CLIA ID#05D0899 Natera, Inc., NIPT (6478) 0 Industrial Road Suite 40, San Carlos, CA 94070
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