Veeda Clinical Research Pvt. Ltd. Bioanalytical Method Library. Recently Validated Methods

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1 Recently Validated s 1 Dalfampridine Multiple sclerosis Human Plasma K 3 EDTA LC/MS/MS LCMS Hydroxy Chloroquine Antimalarial Human Plasma K 3 EDTA LC/MS/MS API Lenalidomide Antineoplastic (Multiple myeloma) Human Plasma K 3 EDTA LC/MS/MS LCMS Perampanel Antiepileptic Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 1 of 43 For more information [email protected]

2 Premium s 1 Acitretin Cis Acitretin Psoriasis Human Plasma Na Heparin LC/MS/MS API Aspirin + Salicylic acid (Sensitive) Analgesic Human Plasma K 3 EDTA LC/MS/MS API Atorvastatin Hydroxy Atorvastatin+ 4 - Hydroxy Atorvastatin+ Glimpride+ Glimpride M1 Metabolite Antihyperlipidemic Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Azacitidine Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Bupropion + Hydroxy Bupropion+ Erythro Bupropion + Threo Bupropion Antidepressant and Smoking cessation Human Plasma Sodium Heparin LC/MS/MS Premier XE Bupropion + Hydroxy Bupropion + Erythro Bupropion + Threo Bupropion Antidepressant Human Plasma K 3 EDTA LC/MS/MS Premier XE Disulfiram For Chronic Alcoholism Human Plasma Na Heparin LC/MS/MS API Doxorubicin Metabolite (Doxorubicinol) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Doxorubicin(Free) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Doxorubicin(Liposomal) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Doxorubicin (Total) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Doxorubicin (Free) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 2 of 43 For more information [email protected]

3 Premium s 13 Doxorubicin (Liposomal) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Ergocalciferol Vitamin D2 Human Plasma K 3 EDTA LC/MS/MS API Estrone Unconjugated + Estradiol Unconjugated + Norethindrone Oestrogen Oestrogen Progestogen Human Plasma K 3 EDTA LC/MS/MS API Ethinyl Estradiol(Sensitive) + Levonorgestrel Oestrogen Progestogen Human Plasma Na Heparin LC/MS/MS API Equilin Total + 8,9-dehydroestrone Total Oestrogen Human Plasma K 3 EDTA LC/MS/MS API Estrone Total Oestrogen Human Plasma K 3 EDTA LC/MS/MS API Estrone Uncojugated + Equilin Unconjugated + 8,9 Dehydroestrone Unconjugated Oestrogen Human Plasma K 3 EDTA LC/MS/MS LCMS Fesoterodine + 5-OH Methyl Tolterodine Antimuscarinic Human Plasma K 3 EDTA LC/MS/MS API Fingolimod + Fingolimod Phosphate Multiple sclerosis Human Blood K 3 EDTA LC/MS/MS API cis-Retinoic Acid+ 4-Keto 13-cis-Retinoic Acid Vitamin A Human Plasma K 3 EDTA LC/MS/MS Premier XE Hydroxy Oleic Acid Synthetic derivative of Oleic Acid Human Plasma Na-Heparin LC/MS/MS API R-Ibuprofen+ S-Ibuprofen Analgesic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 3 of 43 For more information [email protected]

4 25 Isoniazide + Rifampicin Desacetyl Rifampicin+ Ethambutol + Pyrazinamide Antibacterial Human Plasma Na Heparin LC/MS/MS API Premium s 26 Lurasidone Metabolite Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Metformin+ Pioglitazone+ Hydroxy Pioglitazone R-Metoprolol+ S-Metoprolol Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API S-Methyl N, N- Diethyl dithiocarbamate (Disulfiram Secondary For Chronic Alcoholism Human Plasma Na Heparin LC/MS/MS API Metabolite ) 30 Niacin + Nicotinuric Acid(Metabolite) Vitamin Human Plasma K 3 EDTA LC/MS/MS API Penicillamine Chelating Agent Human Plasma K 3 EDTA LC/MS/MS Premier XE Phenindione Anticoagulant/Vitamin K antagonist Human Plasma K 3 EDTA LC/MS/MS API Prednisolone Corticosteroid Human Plasma K 3 EDTA LC/MS/MS API Prpranolol Total + 4-OH Propranolol Total Beta adrenoceptor Blocking Agent Human Plasma K 3 EDTA LC/MS/MS Premier XE Pyridostigmine Anticholinesterase Human Plasma K 3 EDTA LC/MS/MS Premier XE Rivastigmine(Sensitive) Alzheimer's & Parkinson's Disease Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 4 of 43 For more information [email protected]

5 Premium s 37 cis & trans-phytonadione Vitamin K Human Plasma K 3 EDTA LC/MS/MS API R-(+) -trans -tranylcypromine + S-(-) -trans-tranylcypromine Antidepressant and Anxiolytic Human Plasma K 3 EDTA LC/MS/MS API Trientine + N1 -Acetyl triethylenetetramine Chelating agent Human Plasma K3EDTA LC/MS/MS API Trientine + N1 -Acetyl triethylenetetramine + N1,N10 -Diacetyl triethylenetetramine Chelating agent plasma K 3 EDTA LC/MS/MS API Nitroglycerin + 1, 2-Dinitroglycerin + 1, 3-Dinitroglycerin Vasodilator Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 5 of 43 For more information [email protected]

6 Pharmacodynamic / Pharmacokinetic / Immunogenicity Determination (Validated Kit ) Sr. No. Activity/Marker Purpose Matrix 1 Nitrate Marker For the Activity of Nitric oxide synthase and the production of Nitric oxide radicals Human Plasma K 3 EDTA Colourimetric Microplate Reader 5 µm 35 µm 2 Nitrite Marker For the Activity of Nitric oxide synthase and the production of Nitric oxide radicals Human Plasma K 3 EDTA Colourimetric Microplate Reader 5 µm 35 µm 3 Anti Xa LMWH therapy is monitored by the ratio of anti-factor Xa and Anti Factor IIa assay, The amount of residual factor Xa or Factor IIa is inversely proportional to the amount of heparin/lmwh in the plasma Human Plasma Na-Citrate Chromogenic Microplate Reader 0.1 IU/mL 1 IU/mL 4 Anti IIa LMWH therapy is monitored by the ratio of anti-factor Xa and Anti Factor IIa assay, The amount of residual factor Xa or Factor IIa is inversely proportional to the amount of heparin/lmwh in the plasma Human Plasma Na-Citrate Chromogenic Microplate Reader 0.05 IU/mL 0.2 IU/mL 5 TFPI Extrinsic Pathway- Tissue Factor Pathway Inhibitor, For Determination of heparin Presence. Human Plasma CTAD ELISA- Colorimetric Microplate Reader pg/ml 2.0 ng/ml 6 Heparin Clotting Assay To determine the clotting time difference in presence of LMWH Human Plasma CTAD Clotting Assay Coagulation Analyzer 0.15 IU/mL 1.0 IU/mL 7 IgG Immunoglobulin- IgG, specific Heparin antibody qualitative detection for immunogenicity of LMWH Human Serum NA Qualitative-ELISA Microplate Reader NA NA Last Updated: 06 Jan 2016 Page 6 of 43 For more information [email protected]

7 Pharmacodynamic / Pharmacokinetic / Immunogenicity Determination (Validated Kit ) Sr. No. Activity/Marker Purpose Matrix 8 IgA Immunoglobulin- IgA, specific Heparin antibody qualitative detection for immunogenicity of LMWH Human Serum NA Qualitative-ELISA Microplate Reader NA NA 9 IgM Immunoglobulin- IgM, specific Heparin antibody qualitative detection for immunogenicity of LMWH Human Serum NA Qualitative-ELISA Microplate Reader NA NA 10 IgGAM Immunoglobulin- IgG, IgM and IgA, specific Heparin antibodies qualitative detection for immunogenicity of LMWH Human Serum NA Qualitative-ELISA Microplate Reader NA NA 11 A-H-PF4 Anti Heparin Platlate factor Human Plasma CTAD ELISA- Colorimetric Microplate Reader NA NA 12 Total Iron For Estimation of total Iron after Iron sucrose therepy Human Serum NA Colourimetric Microplate Reader 500 ng/ml ng/ml 13 Transferrin bound Iron(TBI) For Estimation of transferrin bound Iron after Iron sucrose therapy Human Serum NA Colorimetric Microplate Reader 200 ng/ml 8000 ng/ml Last Updated: 06 Jan 2016 Page 7 of 43 For more information [email protected]

8 Validated s for New Chemical Entities Sr. No. In-House ID Matrix 1 VIN-NCE-001 PL-1 Human Plasma Na Heparin LC/MS/MS API VIN-NCE-001 UR-1 Human Urine NA LC/MS/MS API VIN-NCE-002 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-003 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-004 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-005 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-006 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-007 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-008 PL Human Plasma K 2 EDTA LC/MS/MS API VIN-NCE-008 UR Human Urine NA LC/MS/MS API VIN-NCE-009 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-009 UR Human Urine NA LC/MS/MS API VIN-NCE-010 PL Human Plasma K 3 EDTA LC/MS/MS API VIN-NCE-011 PL Human Plasma Na Heparin LC/MS/MS API Last Updated: 06 Jan 2016 Page 8 of 43 For more information [email protected]

9 Validated s for New Chemical Entities Sr. No. In-House ID Matrix 15 VIN-NCE-012 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-014 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-013 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-015 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-016 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-017 BL Human Blood Na Heparin LC/MS/MS Premier XE VIN-NCE-018 BL Human Blood Na Heparin LC/MS/MS API VIN-NCE-019 PL Human Plasma EDTA LC/MS/MS API VIN-NCE-020 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-021 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-022 SK Human Skin Na Heparin LC/MS/MS API VIN-NCE-023 PL Human Plasma Na Heparin LC/MS/MS API VIN-NCE-024 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-025 UR Human Urine Na Heparin LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 9 of 43 For more information [email protected]

10 Validated s for New Chemical Entities Sr. No. In-House ID Matrix 29 VIN-NCE-026 PL Human Blood EDTA LC/MS/MS API VIN-NCE-027 PL Human Plasma EDTA LC/MS/MS API VIN-NCE-028 PL Human Plasma EDTA LC/MS/MS Premier XE VIN-NCE-029 PL Human Plasma Na Heparin LC/MS/MS Premier XE VIN-NCE-030 TI Colon tissue NA LC/MS/MS API VIN-NCE-022 CT Colon tissue NA LC/MS/MS API VIN-NCE-031 PL Human Plasma K2EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 10 of 43 For more information [email protected]

11 s Under Development / Validation 1 Abiraterone Prostate Cancer Human Plasma K 3 EDTA LC/MS/MS Acitretin Psoriasis Human Plasma K 3 EDTA LC/MS/MS Allopurinol Gout Human Plasma K 3 EDTA LC/MS/MS Amlodipine + Olmesartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS Amphotericin (free)+ Amphotericin (Liposomal) Antifungal Human Plasma K 3 EDTA LC/MS/MS Fingolimod Multiple Sclerosis Human Plasma K 2 EDTA LC/MS/MS Isotretinoin acne Human Plasma K 3 EDTA LC/MS/MS Miglustat Gaucher disease Human Plasma K 3 EDTA LC/MS/MS Scopolamine Anticholinergic Human Plasma K 3 EDTA LC/MS/MS Tacrolimus Immunosuppressant Human Blood K 3 EDTA LC/MS/MS Tacrolimus Immunosuppressant Human Blood K 3 EDTA LC/MS/MS Zinc (from Zinc Acetate) Inhibit the absorption of copper in Wilson's disease Human Plasma K 3 EDTA ICP OES Last Updated: 06 Jan 2016 Page 11 of 43 For more information [email protected]

12 Validated List 1 Abacavir Antiviral Human Plasma K 3 EDTA LC/MS/MS API Acetaminophen Analgesic Human Plasma Na Heparin LC/MS/MS API Acetazolamide 4 Acetazolamide (Sensitive) 5 Acetazolamide Carbonic anhydrase inhibitor, diuretic Carbonic anhydrase inhibitor, diuretic Carbonic anhydrase inhibitor, diuretic Human Plasma K 3 EDTA LC/MS/MS API Human Plasma EDTA LC/MS/MS API Human Plasma K 3 EDTA LC/MS/MS API Acitretin Cis Acitretin Psoriasis Human Plasma K 3 EDTA LC/MS/MS API Agomelatine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Agomelatine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Amlodipine + Valsartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Albendazole + Albendazole Sulfoxide Anthelmintic Human Plasma K 3 EDTA LC/MS/MS API Alfuzosin Antihypertensive Human Plasma EDTA LC/MS/MS API Aliskiren Renin inhibitor Human Plasma K 3 EDTA LC/MS/MS API Alosetron 5-HT3 Antagonist Human Plasma K 3 EDTA LC/MS/MS API Alprazolam Anxiolytic Human Plasma Na Heparin LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 12 of 43 For more information [email protected]

13 Validated List 15 Amantadine Antiviral and an Antiparkinsonian drug Human Plasma K 3 EDTA LC/MS/MS API Amitriptyline+ Nortriptyline Antidepressant Human Plasma K 2 EDTA LC/MS/MS Premier XE Amitriptyline+ Nortriptyline Antidepressant Human Plasma K 2 EDTA LC/MS/MS Premier XE Amlodipine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Amlodipine + Telmisartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Amoxicillin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Amoxicillin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Amoxicillin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Anastrazole Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Aprepitant Antiemetic Human Plasma K 3 EDTA LC/MS/MS API Aripiprazole psychotic Human Plasma K 3 EDTA LC/MS/MS API Armodafinil Wakefulness promoting agent Human Plasma K 3 EDTA LC/MS/MS API Artemether+ Dihydroartimisnin Antimalarial Human Plasma Na Heparin LC/MS/MS API Artesunate + Dihydroartemisinin Antimalarial Human Plasma K 3 EDTA LC/MS/MS LCMS Last Updated: 06 Jan 2016 Page 13 of 43 For more information [email protected]

14 Validated List 29 Asenapine Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Aspirin + Salicylic Acid Analgesic Human Plasma Na Heparin LC/MS/MS API Aspirin + Metabolite Salicylic acid Analgesic Human Plasma K 3 EDTA LC/MS/MS API Aspirin(Sensitive) Analgesic Human Plasma K 3 EDTA LC/MS/MS Premier XE Atenolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Atomoxetine Hyperactivity disorder (ADHD) Human Plasma EDTA LC/MS/MS API Atorvastatin Antihyperlipidemic Human Plasma CPDA, EDTA LC/MS/MS API Atorvastatin Hydroxy Atorvastatin+ 4 - Hydroxy Atorvastatin Antihyperlipidemic Human Plasma EDTA LC/MS/MS API Atorvastatin Hydroxy Atorvastatin+ 4 - Hydroxy Atorvastatin Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Atorvastatin+ 2 - Hydroxy Atorvastatin+ 4 - Hydroxy Atorvastatin Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Atorvastatin Hydroxy Atorvastatin+ 4 - Hydroxy Atorvastatin+ Glimpride Antihyperlipidemic Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Atovaquone Antiprotozoal Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 14 of 43 For more information [email protected]

15 Validated List 41 Axitinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Azithromycin Antibiotics Human Plasma K 3 EDTA LC/MS/MS API Azithromycin Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Barnidipine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Bexarotene Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Bisoprolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Budesonide Glucocorticoid Human Plasma K 3 EDTA LC/MS/MS LCMS Bortezomib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS LCMS Bortezomib Antineoplastic Human Plasma Na Heparin LC/MS/MS LCMS Bosentan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Bosentan(Sensitive ) Endothelin receptor antagonist Human Plasma K 3 EDTA LC/MS/MS API Bupropion + Hydroxy Bupropion Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Buspiron Anxiolytic Human Plasma K 3 EDTA LC/MS/MS API Cabergoline Dopamine receptor agonist Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 15 of 43 For more information [email protected]

16 Validated List 55 Candesartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS Premier XE Candesartan + Hydrochlorothiazide Antihypertensive Diuretic Human Plasma K 3 EDTA LC/MS/MS API Capecitabine Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Carbamazepine Antiepileptic Human Plasma K 3 EDTA LC/MS/MS API Carbamazepine Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API Carbidopa+ Levodopa Parkinson's disease Human Plasma K 3 EDTA LC/MS/MS Premier XE Carbidopa + Levodopa Parkinson's disease Human Plasma K 3 EDTA LC/MS/MS API Carvedilo + 4-Hydroxyphenyl Carvedilol Beta blocker Human Plasma K 3 EDTA LC/MS/MS Premier XE Carglumic Acid Carbamoyl Phosphate Synthetase 1 activator Human Plasma K 3 EDTA LC/MS/MS API Cefaclor Antibacterial Human Plasma CPDA, EDTA HPLC HPLC-UV Cefaclor Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Cefadroxil Antibiotic Human Plasma CPDA, EDTA LC/MS/MS API Cefadroxil Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Cefditoren Antibiotic Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 16 of 43 For more information [email protected]

17 Validated List 69 Cefixime Antibacterial Human Plasma EDTA HPLC-UV HPLC-UV Cefixime Cephalosporin Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Cefixime Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Cefpodoxime acid Antibacterial Human Plasma EDTA LC/MS/MS API Cefpodoxime acid Antibacterial Human Plasma EDTA HPLC-UV HPLC-UV Cefuroxime acid Antibacterial Human Plasma EDTA HPLC-UV HPLC-UV Cefuroxime acid Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Celecoxib Sulfa non-steroidal antiinflammatory drug (NSAID) Human Plasma K 3 EDTA LC/MS/MS API Cephalexin Antibacterial Human Plasma EDTA HPLC HPLC-UV Cephalexin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Cetirizine Non-sedative Antihistamine Human Plasma K 3 EDTA LC/MS/MS API Chlorthalidone Diruretic Human Plasma K 3 EDTA LC/MS/MS LC Cinnargine Antihistamine Human Plasma EDTA LC/MS/MS Premier XE Ciprofloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 17 of 43 For more information [email protected]

18 Validated List 83 Clarithromycin Antibacterial Human Plasma EDTA LC/MS/MS API Clarithromycin + 14(R)-hydroxy-Clarithromycin Antibacterial Human Plasma EDTA LC/MS/MS API Clomipramine + Desmethyl Clomipramine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Clonazepam AED Human Plasma K 3 EDTA LC/MS/MS Premier XE Clonazepam AED Human Plasma K 3 EDTA LC/MS/MS LCMS Clonidine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Clopidogrel Anti platelet Human Plasma CPDA, EDTA LC/MS/MS API Clopidogrel Anti platelet Human Plasma K 3 EDTA LC/MS/MS API Clopidogrel+ Clopidogrel Carboxylic acid Anti platelet Human Plasma K 3 EDTA LC/MS/MS API Clozapine Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Dapsone Antileprotic Human Plasma K 3 EDTA LC/MS/MS API Dapsone + N-Acetyl Dapsone Antileprotic Human Plasma K 3 EDTA LC/MS/MS LCMS Darunavir Antiretroviral Human Plasma K 3 EDTA LC/MS/MS Premier XE Dasatinib Tyrosine Kinase Inhibitor/Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 18 of 43 For more information [email protected]

19 Validated List 97 Deferasirox Iron Chelator Human Plasma K 3 EDTA LC/MS/MS API Deferiprone + Deferiprone Glucuronide Iron Chelator Human Plasma Na Heparin LC/MS/MS API Desipramine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Desipramine + 2-Hydroxy Desipramine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Desloratadine Antihistamine Human Plasma CPDA, EDTA LC/MS/MS API Desloratadine + 3-Hydroxy Desloratidine Desloratidine + 3-Hydroxy Desloratidine Antihistamine Human Plasma K 3 EDTA LC/MS/MS API Antihistamine Human Plasma EDTA LC/MS/MS API Desmopressin Synthetic replacement of vasopressin harmone Human Plasma K 3 EDTA LC/MS/MS APi Dexlansoprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Dextromethorphan + Dextrorphan Cough Suppressant Human Plasma K 3 EDTA LC/MS/MS API Dextromethorphan + Guanafenesin Cough Suppressant Expectorant Human Plasma K 3 EDTA LC/MS/MS API Diclofenac Analgesic Human Plasma K 3 EDTA LC/MS/MS API Diltiazem + N-Desmethyl Diltiazem + Desacetyl Diltiazem Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 19 of 43 For more information [email protected]

20 Validated List 110 Diltiazem + N-Desmethyl diltiazem + Desacetyl diltazem Antihypertensive Human Plasma K 3 EDTA LC/MS/MS LCMS Dipyridamole Vasodilator Human Plasma K 3 EDTA LC/MS/MS API Dipyridamole Vasodilator Human Plasma K 3 EDTA LC/MS/MS API Donepezil Nootropic Human Plasma K 3 EDTA LC/MS/MS Premier XE Donepezil Mementine Alzheimer Human Plasma K 3 EDTA LC/MS/MS API Doxorubicin (Total) Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Doxycycline Antibacterial Human Plasma Na Heparin LC/MS/MS Premier XE Doxycycline Antibacterial Human Plasma EDTA LC/MS/MS Premier XE Doxycycline Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Dronedarone+ Desbutyl Dronedarone (Metabolite) Antiarrhythmic Human Plasma K 3 EDTA LC/MS/MS Premier XE Duloxetine (Sensitive) Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Duloxetine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Dutastaride 5-alpha-reductase inhibitor Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 20 of 43 For more information [email protected]

21 Validated List 123 Efavirenz Antiviral Human Plasma EDTA HPLC HPLC-UV Efavirenz Antiviral Human Plasma K 3 EDTA LC/MS/MS API Eletriptan Migraine Human Plasma Na Heparin LC/MS/MS Premier XE Emtricitabin Antiviral Human Plasma K 3 EDTA LC/MS/MS API Enalapril + Enalaprilat Antihypertensive Human Plasma EDTA LC/MS/MS API Entacapone + Metabolite Entacapone + Metabolite (Sensitive) Antiparkinsonian Human Plasma K 3 EDTA HPLC HPLC-UV Antiparkinsonian Human Plasma K 3 EDTA LC/MS/MS Premier XE Entecavir Antiviral Human Plasma K 3 EDTA LC/MS/MS API Enzalutamide Metastatic castration-resistant prostate cancer (CRPC) Human Plasma K 3 EDTA LC/MS/MS API Eprosartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Eprosartan + Hydrochlorothiazide Antihypertensive Diuretic Human Plasma K 3 EDTA LC/MS/MS API Eprosartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Erlotinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Erythromycin Antibacterial Human Plasma EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 21 of 43 For more information [email protected]

22 Validated List 137 Erythromycin Antimicrobial Human Plasma K 3 EDTA LC/MS/MS Premier XE Escitalopram Antidepressant Human Plasma CPDA, EDTA LC/MS/MS API Escitalopram Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Escitalopram + S (+) Desmethylcitalopram Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Esomeprazole Proton pump inhibitor Human Plasma CPDA, EDTA LC/MS/MS API Esomeprazole (Sensitive) Proton pump inhibitor Human Plasma EDTA LC/MS/MS API Esomeprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Esomeprazole + Naproxen Proton pump inhibitor Analgesic Human Plasma K 3 EDTA LC/MS/MS API Esomeprazole+ Naproxen Proton pump inhibitor NSAID Human Plasma K 3 EDTA LC/MS/MS API Ethinyl Esterdiol + Levonorgetral Oestrogen Human Plasma Sodium Heparin LC/MS/MS API Etodolac Non-steroidal inflammatory Human Plasma K 3 EDTA LC/MS/MS API Etodolac Nonsteroidal anti-inflammatory Human Plasma K 3 EDTA LC/MS/MS Premier XE Etoposide Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Etoricoxib COX-2 selective inhibitor Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 22 of 43 For more information [email protected]

23 Validated List 151 Everolimus Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Exemestane Aromatase inhibitor, Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Ezetimibe(Unconjugated) Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Ezetimib (Total) Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS LCMS Ezetimibe+ Ezetimibe Phenoxygluconoride Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Febuxostat Inhibitor of Xanthine Oxidase Human Plasma K 3 EDTA LC/MS/MS API Felodipine Antihypertensive Human Plasma CPDA, EDTA LC/MS/MS API Felodipine Calcium channel blocker Human Plasma K 3 EDTA LC/MS/MS API Fenofibric Acid Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Fenofibric Acid Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Fenoprofen Non-steroidal inflammatory Human Plasma K 3 EDTA LC/MS/MS API Fesoterodine + 5-Hydyroxy methyl tolterodine Antimuscarinic Human Plasma K 3 EDTA LC/MS/MS API Fexofenadine Antihistamine Human Plasma CPDA, EDTA LC/MS/MS API Fexofenadine + Pseudoephedrine Antihistamine Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 23 of 43 For more information [email protected]

24 Validated List 165 Fexofenedine + Pseudoephedrine (Sensitive) Antihistamine Human Plasma K 3 EDTA LC/MS/MS Premier XE Flecainide Anti arrhythmic Human Plasma K 3 EDTA LC/MS/MS Premier XE Fluconazole Antifungal Human Plasma CPDA, EDTA LC/MS/MS API Flucytosine Antimycotic Human Plasma K 3 EDTA LC/MS/MS API Fluoxetine + Norfluoxetine Antidepressant Human Plasma EDTA LC/MS/MS API Fulvestrant Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Gabapentin Anticonvulsant Human Plasma EDTA LC/MS/MS API Gabapentin Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API Glibenclamide (Glyburide) Antidiabetic Human Plasma EDTA LC/MS/MS API Gliclazide Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Glimepiride Antidiabetic Human Plasma EDTA LC/MS/MS API Glimpiride Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Glipizide Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Griseofulvin Antifungal Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 24 of 43 For more information [email protected]

25 Validated List 179 Granisetron Anti emetic Human Plasma EDTA LC/MS/MS API Guaifenesin Expectorant Human Plasma K 3 EDTA LC/MS/MS API Guaifenesin Expectorant Human Plasma K 3 EDTA LC/MS/MS Premier XE Hydralazine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS LCMS Hydrochlorothiazide Diuretic Human Plasma EDTA LC/MS/MS API Hydrochlorothiazide (Sensitive) Diuretic Human Plasma EDTA LC/MS/MS API Hydrochlorothiazine + Telmisartan Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Hydroxycarbamide Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Ibuprofen Analgesic Human Plasma K 3 EDTA LC/MS/MS Premier XE Ibuprofen Nonsteroidal anti-inflammatory Human Plasma K 3 EDTA LC/MS/MS Premier XE Ibuprofen Nonsteroidal natiinflammatory Human Plasma K 3 EDTA LC/MS/MS API Imatinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Imatinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Indomethacin Nonsteroidal anti-inflammatory Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 25 of 43 For more information [email protected]

26 Validated List 193 Indoramin Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Irbesaratan + Hydrochlorothiazide Antihypertensive Diuretic Human Plasma K 3 EDTA LC/MS/MS API Isotretinoin acne Human Plasma K 3 EDTA LC/MS/MS LCMS Itraconazole Antifungal Human Plasma CPDA, EDTA LC/MS/MS API Itraconazole + Hydroxy Itraconazole Antifungal Human Plasma K 3 EDTA LC/MS/MS API Ivabradine Heart rate lowering agent Human Plasma K 3 EDTA LC/MS/MS Premier XE Ketoprofen Inflammatory, Analgesic Human Plasma K 3 EDTA LC/MS/MS API Lacosamide AED Human Plasma K 3 EDTA LC/MS/MS LCMS Lamivudine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Lamotrigine Anticonvulsant, Anti epileptic Human Plasma K 3 EDTA LC/MS/MS Premier XE Lamuvudine + Zidovudine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Lamuvudine + Abacavir Antiviral Human Plasma EDTA LC/MS/MS API Lamuvudine + Neverapine + Zidovudine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 26 of 43 For more information [email protected]

27 Validated List 206 Lamuvudine + Neverapine + Zidovudine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Lansoprazole Proton pump inhibitor Human Plasma EDTA LC/MS/MS API Lansoprazole (Sensitive) Proton pump inhibitor Human Plasma EDTA LC/MS/MS API Lansoprazole Proton-pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Lapatinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Lenalidomide Antineoplastic (Multiple myeloma) Human Plasma K 3 EDTA LC/MS/MS LCMS Letrozole Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Levetiracetam Anti epileptic Human Plasma K 3 EDTA LC/MS/MS Premier XE Levetiracetam Anti epileptic Human Plasma K 3 EDTA LC/MS/MS Premier XE Levocetirizine Non-sedative antihistamine Human Plasma K 3 EDTA LC/MS/MS API Levofloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Levothyroxine Thyroid Hormone Defficiency Human Serum NA LC/MS/MS Premier XE Linezolid Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Lisinopril Antihypertensive Human Plasma EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 27 of 43 For more information [email protected]

28 Validated List 220 Lisinopril Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Lithium Antidepressant Human Plasma K 3 EDTA ICP OES Optima Loperamide Antidiarrheal Human Plasma K 3 EDTA LC/MS/MS API Lopinavir + Ritonavir Antiretroviral Human Plasma K 3 EDTA LC/MS/MS Premier XE Loratadine + Desloratadine Antihistamine Human Plasma CPDA, EDTA LC/MS/MS API Losartan Angiotensin II Receptor Antagonist Human Plasma K 3 EDTA LC/MS/MS API Lumefantrine Antimalarial Human Plasma Na Heparin LC/MS/MS Premier XE Lurasidone Antipsycotic Human Plasma K 3 EDTA LC/MS/MS API Maraviroc Antiviral Human Plasma K 3 EDTA LC/MS/MS API Mefenamic Acid (Sensitive) Non-steroidal inflammatory Human Plasma K 3 EDTA LC/MS/MS API Mefenamic Acid (Sensitive) Non-steroidal inflammatory Human Plasma K 3 EDTA LC/MS/MS API Mefenamic acid Non steroial anti inflammatory Human Plasma K 3 EDTA LC/MS/MS API Memantine Alzheimer's Human Plasma EDTA LC/MS/MS API Mercaptopurine Immunosuppressant Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 28 of 43 For more information [email protected]

29 Validated List 234 Mesalamine inflammatory Human Plasma K 3 EDTA LC/MS/MS API Metaxalone Muscle Relaxant Human Plasma K 3 EDTA LC/MS/MS API Metformin Antidiabetic Human Plasma EDTA HPLC HPLC-UV Metformin Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Methotrexate antimetabolite and antifolate Human Plasma EDTA LC/MS/MS API Methoxsalen Dermatological Human Plasma EDTA LC/MS/MS API Methoxsalen (Sensitive) Dermatological Human Plasma EDTA LC/MS/MS API Methyl Prednisolone Glucocorticoid Human Plasma K 3 EDTA LC/MS/MS API Metoprolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Metoprolol Antihypertensive Human Plasma EDTA LC/MS/MS API Metoprolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Metronidazole Antibacterial Human Plasma CPDA, EDTA HPLC HPLC-UV Metronidazole Antibacterial Human Plasma K 3 EDTA LC/MS/MS Premier XE Metronidazole Antibacterial Human Stool NA LC/MS/MS API Last Updated: 06 Jan 2016 Page 29 of 43 For more information [email protected]

30 Validated List 248 Minocycline Antibiotic Human Plasma Na Heparin LC/MS/MS API Minocycline Antibiotic Human Plasma K 2 EDTA LC/MS/MS API Mirabegron Urinary incontinence Human Plasma Na Heparin LC/MS/MS API Mono Methyl Fumarate Multiple Sclerosis Human Plasma K 3 EDTA LC/MS/MS API Montalukast+ Fexofenadin leukotriene receptor antagonist Antihistamine Human Plasma K 3 EDTA LC/MS/MS API Montelukast leukotriene receptor antagonist Human Plasma EDTA LC/MS/MS API Moxifloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Moxifloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Mycophenolate Mofetil + Immunosuppressant Human Plasma CPDA, EDTA LC/MS/MS API Mycophenolate Mofetil (Sensitive) Immunosuppressant Human Plasma EDTA LC/MS/MS API Mycophenolic acid Immunosuppressant Human Plasma CPDA, EDTA LC/MS/MS API Mycophenolic acid Immunosuppressant Human Plasma K 3 EDTA LC/MS/MS API Nadolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Naproxen NSAID Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 30 of 43 For more information [email protected]

31 Validated List 262 Naproxen Analgesic Human Plasma K 3 EDTA LC/MS/MS API Naratriptan migraine Human Plasma K 3 EDTA LC/MS/MS Premier XE Nateglinide Antidiabetic Human Plasma EDTA LC/MS/MS API Nebivolol Antihypertensive Human Plasma EDTA LC/MS/MS API Nebivolol Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Nifedipine Antihypertensive Human Plasma EDTA LC/MS/MS API Nefopam Analgesic Human Plasma K 3 EDTA LC/MS/MS API Nevirapine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Nilutamide Antiandrogen Human Plasma K 3 EDTA LC/MS/MS API Nilotinib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS API Nitrofurantoin Antibiotic Human Plasma EDTA LC/MS/MS API Nitrofurantoin Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Norfloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Nortriptyline Antidepressant Human Plasma EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 31 of 43 For more information [email protected]

32 Validated List 276 Ofloxacin Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Olanzapine Antipsychotic Human Plasma EDTA LC/MS/MS API Olmesartan 279 Olmesartan + Hydrochlorothiazide Angiotensin II receptor antagonist Angiotensin II receptor antagonist Diuretic Human Plasma K 3 EDTA LC/MS/MS API Human Plasma K 3 EDTA LC/MS/MS API Olsalazine Ulcerative colitis Human Plasma K 3 EDTA LC/MS/MS API Omeprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Omeprazole Proton Pump Inhibitor Human Plasma K 3 EDTA LC/MS/MS API Orphenadrine Antihistamine Human Plasma K 3 EDTA LC/MS/MS API Oseltamivir + Oseltamivir Carboxylate Antiviral Human Plasma K 3 EDTA LC/MS/MS API Oxaprozin Total NSAID Human Plasma K 3 EDTA LC/MS/MS LCMS Oxcarbazepine + 10, 11-Dihydro-10-hydroxy- Carbamazepine Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API Oxybutynin + Metabolite- N-Desethyl Anticholinergic Human Plasma K 3 EDTA LC/MS/MS API Paclitaxel (Free) Antineoplastic Human Plasma Na Heparin LC/MS/MS API Last Updated: 06 Jan 2016 Page 32 of 43 For more information [email protected]

33 Validated List 289 Paclitaxel (Total) Antineoplastic Human Plasma Na Heparin LC/MS/MS API Paliperidone Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Paliperidone Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Paliperidone Antipsychotic Human Plasma K 3 EDTA LC/MS/MS API Pantoprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Pantoprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Paracetamol Antipyretic Human Plasma K 3 EDTA LC/MS/MS API Paroxetin Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Paroxetine Antidepressant Human Plasma CPDA, EDTA LC/MS/MS API Phenobarbital AEDs Human Plasma K 2 EDTA LC/MS/MS Premier XE Pimozide Antipsychotic Human Plasma K 3 EDTA LC/MS/MS LCMS Pindolol Beta Blocker Human Plasma K 3 EDTA LC/MS/MS API Pioglitazone + Hydroxy Pioglitazone M IV Antihyperglycemic, antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Piroxicam NSAID Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 33 of 43 For more information [email protected]

34 Validated List 303 Posaconazole Antifungal Human Plasma K 3 EDTA LC/MS/MS API Pramipexole Antiparkinsonian Human Plasma EDTA LC/MS/MS API Pravastatin Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS LCMS Pravastatin Antihyperlipidemic Human Plasma EDTA LC/MS/MS API Praziquantal Anthelmintic Human Plasma K 3 EDTA LC/MS/MS API Pregabalin Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS Premier XE Pregabalin Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS Premier XE Pregabalin+ Gabapentin+ Carbamazepine+ Levetiracetam AEDs Human Plasma K2EDTA LC/MS/MS Premier XE Primidone Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API Pottasium Hypokalaemia Human Urine NA ICP OES Optima Prochlorperazine Tranquilliser Human Plasma K 3 EDTA LC/MS/MS API Proguanil Antimalarial Human Plasma K 3 EDTA LC/MS/MS API Promethazine Antihistaminic Human Plasma K 3 EDTA LC/MS/MS API Propafenone + 5-Hydroxy metabolite arrhythmic Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 34 of 43 For more information [email protected]

35 Validated List 317 Propranolol + 4-Hydroxy Propranolol(Free) Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Quetiapine Antipsychotic Human Plasma EDTA LC/MS/MS Premier XE Quetiapine Antipsychotic Human Plasma K 3 EDTA LC/MS/MS Premier XE Quinine Antimalarial Human Plasma K 3 EDTA LC/MS/MS API Rabeprazole Proton pump inhibitor Human Plasma EDTA LC/MS/MS API Rabeprazole Proton pump inhibitor Human Plasma K 3 EDTA LC/MS/MS API Raltegravir Antiretroviral Human Plasma K 3 EDTA LC/MS/MS API Ramipril Antihypertensive Human Plasma EDTA LC/MS/MS API Ramipril+ Ramiprilat Antihypertensive Human Plasma K 3 EDTA LC/MS/MS Premier XE Ranitidine Antihistamine Human Plasma EDTA LC/MS/MS API Ranolazine Antianginal Human Plasma K 3 EDTA LC/MS/MS Premier XE Rasagiline Parkinsons disease plasma K 3 EDTA LC/MS/MS Waters Repaglinide Antidiabetic Human Plasma EDTA LC/MS/MS API Rifixamine Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 35 of 43 For more information [email protected]

36 Validated List 331 Rilpivirin Non-nucleoside Reverse Transcriptase Inhibitor Human Plasma K 3 EDTA LC/MS/MS API Risperidone + 9-Hydroxy Risperidone Antipsychotic Human Plasma K 3 EDTA LC/MS/MS Premier XE Ritonavir Antiretroviral Human Plasma K 3 EDTA LC/MS/MS Premier XE Rivoroxaban Oral Anticoagulant Human Plasma K 3 EDTA LC/MS/MS API Rivaroxaban Oral Anticoagulant Human Plasma K 3 EDTA LC/MS/MS Premier XE Rivastigmine Alzheimer's&Parkinson's Disease Human Plasma K 3 EDTA LC/MS/MS Premier XE Rizatriptan migraine Human Plasma K 3 EDTA LC/MS/MS Premier XE Rizatriptan Migraine Human Plasma K 3 EDTA LC/MS/MS Premier XE Roflumilast + Roflumilast N-Oxide Severe COPD associated with chronic bronchitis Human Plasma K 3 EDTA LC/MS/MS Premier XE Ropinirole Antiparkinsonian Human Plasma EDTA LC/MS/MS API Ropinirole Antiparkinsonian Human Plasma K 3 EDTA LC/MS/MS API Rosiglitazone + Metformin Antidiabetic Human Plasma EDTA LC/MS/MS API Rosiglitazone + N-Desmethyl Rosiglitazone Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 36 of 43 For more information [email protected]

37 Validated List 344 Rosuvastatin Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS Premier XE Rosuvastatin Lowering Cholesterol Human Plasma K 3 EDTA LC/MS/MS Premier XE Rufinamide Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API S-Amlodipine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API S Amlodipine+ Hydrochlorothiazide Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API S Amlodipine + Hydrochlorothiazide Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API S-Dapoxetine Selective serotonin reuptake inhibitor Human Plasma EDTA LC/MS/MS API Sertraline Antidepressant Human Plasma CPDA, EDTA LC/MS/MS API Sildenafil Antihypertensive, Erectile dysfunction Human Plasma K 3 EDTA LC/MS/MS API Sildenafil + Metabolite Antihypertensive, Erectile dysfunction Human Plasma K 3 EDTA LC/MS/MS API Simvastatin + β - hydroxy Acid Simvastatin + β - hydroxy Acid Antihyperlipidemic Human Plasma EDTA LC/MS/MS API Antihyperlipidemic Human Plasma EDTA LC/MS/MS API Simvastatin + Simvastatin acid Antihyperlipidemic Human Plasma K 3 EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 37 of 43 For more information [email protected]

38 Validated List 357 Sirolimus Immunosuppressant Human Blood EDTA LC/MS/MS API Sirolimus (Sensitive) Immunosuppressant Human Blood K 3 EDTA LC/MS/MS Premier XE Sitagliptin Antihyperglycemic Human Plasma K 3 EDTA LC/MS/MS API Sodium Phenyl Butyrate + Metabolite Phenyl acetate+ Metabolite Phenylacetylglutamine For Urea cycle disorders Human Plasma K 3 EDTA LC/MS/MS API µg/ml 1 µg/ml 2 µg/ml 750 µg/ml 750µg/mL 300 µg/ml 361 Sofosbuvir + Sofosbuvir GS Antiviral Human Plasma K 3 EDTA LC/MS/MS LC Solifenacin Urinary antispasmodic Human Plasma K 3 EDTA LC/MS/MS Premier XE SolifenacinSensitive) Antimuscarinic Human Plasma K 3 EDTA LC/MS/MS API Sorafenib Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Sulfadiazine Antibacterial Human Plasma K 3 EDTA LC/MS/MS API Sumatripatan migraine Human Plasma K 3 EDTA LC/MS/MS Premier XE Tacrolimus Immunosuppressant Human Blood EDTA LC/MS/MS Premier XE Tacrolimus Immunosuppressant Human Blood EDTA LC/MS/MS Premier XE Tadalafil Antihypertensive, Erectile dysfunction Human Plasma K 3 EDTA LC/MS/MS LCMS Last Updated: 06 Jan 2016 Page 38 of 43 For more information [email protected]

39 Validated List 370 Tamsulosin α 1a -selective alpha blocker Human Plasma K 3 EDTA LC/MS/MS Premier XE Telmisartan Antihypertensive Human Plasma EDTA LC/MS/MS API Telmisartan Antihypertensive Human Plasma EDTA LC/MS/MS API Telmisartan + Amlodipine Antihypertensive Human Plasma K 3 EDTA LC/MS/MS API Temozolamide Antineoplastic Human Plasma K 3 EDTA LC/MS/MS Premier XE Tenofovir Antiviral Human Serum NA LC/MS/MS API Tenofovir + Emtricitabine + Lamivudine Antiviral Human Plasma EDTA LC/MS/MS API Tenofovir Antiviral Human Plasma K 3 EDTA LC/MS/MS API Tenofovir+ Emtricitabine Antiviral Human Plasma K 3 EDTA LC/MS/MS API Tenofovir + Emtricitabine + Rilpivirine Antiritroviral Human Plasma K 3 EDTA LC/MS/MS API Tenofovir + Emtricitabine + Nevirapine Antiritroviral Human Plasma K 3 EDTA LC/MS/MS API Terbinafine Antifungal Human Plasma EDTA HPLC HPLC-UV Terbinafine Antifungal Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 39 of 43 For more information [email protected]

40 Validated List 383 Teriflunomide Multiple sclerosis Human Plasma K 3 EDTA LC/MS/MS API Tetracycline Antibiotic Human Plasma K 3 EDTA LC/MS/MS API Tiagabine Anticonvulsant Human Plasma EDTA LC/MS/MS API Tinidazole Antiprotozoal Human Plasma K 3 EDTA LC/MS/MS Premier XE Tizanidine Muscle Relexant Human Plasma K 3 EDTA LC/MS/MS Premier XE Tizanidine Muscle Relexant Human Plasma K 3 EDTA LC/MS/MS Premier XE Tolcapone + 3-O-Methyltolcapone Reversible inhibitor of catechol- O-methyltransferase (COMT) Human Plasma K 3 EDTA LC/MS/MS API Tolterodine Antimuscarinic Human Plasma EDTA LC/MS/MS API Tolterodine + 5-Hydroxy Methyl Tolterodine Antimuscarinic Human Plasma EDTA LC/MS/MS API Topiramate Anticonvulsant Human Plasma CPDA, EDTA LC/MS/MS API Topiramate (Sensitive) Anticonvulsant Human Plasma EDTA LC/MS/MS API Torsemide Antihypertensive Human Plasma EDTA LC/MS/MS API Total Iron Iron Defficiency Anaemia Human Serum NA ICP OES Optima Transferrin Bound Iron NA Human Serum NA ICP OES Optima Last Updated: 06 Jan 2016 Page 40 of 43 For more information [email protected]

41 397 Transerrin Bound Iron For Estimation of transferrin bound Iron after Ferrmoxytol and Ferric carboxy maltose therapy Validated List Dog Serum NA ICP OES Optima Tramadol hydrochloride Analgesic Human Plasma K 3 EDTA LC/MS/MS LCMS Trazodone Antidepressant Human Plasma EDTA LC/MS/MS API Trazodone Antidepressant Human Plasma EDTA LC/MS/MS API Trifluoperazine Antipsychotic Human Plasma K 3 EDTA LC/MS/MS LCMS Trimetazidine Antianginal Human Plasma K 3 EDTA LC/MS/MS Premier XE Trospium Urinary Antispasmodic Human Plasma K 3 EDTA LC/MS/MS Premier XE Trospium (Sensitive) Urinary Antispasmodic Human Plasma K 3 EDTA LC/MS/MS Premier XE Valacyclovir + Acyclovir Antiviral Human Plasma K 3 EDTA LC/MS/MS API Valacyclovir + Acyclovir Antiviral Human Plasma K 3 EDTA LC/MS/MS API Valganciclovir + Ganciclovir antiviral Human Plasma K 3 EDTA LC/MS/MS Premier XE Valproic Acid Anticonvulsant Human Plasma K 3 EDTA LC/MS/MS API Valproic Acid Anticonvulsant Human Plasma EDTA LC/MS/MS API Last Updated: 06 Jan 2016 Page 41 of 43 For more information [email protected]

42 Validated List 410 Valsartan Antihypertensive Human Plasma EDTA LC/MS/MS API Valsartan Antihypertensive Human Plasma EDTA LC/MS/MS API Valsartan + Hydrochlorothiazide Venlafaxine + O - Desmethyl Venlafaxine Angiotension II Receptor Antagonist Diuretic Human Plasma K 3 EDTA LC/MS/MS API 4000 Antidepressant Human Plasma EDTA LC/MS/MS API Venlafexine (Sensitive) + O - Desmethyl Venlafaxine Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Vertaric acid Antihypertensive and Antioxidant Human Plasma K 3 EDTA LC/MS/MS API Vildagliptin Anti diabetic Human Plasma K 3 EDTA LC/MS/MS API Vidagliptin + Metformin Antidiabetic Human Plasma K 3 EDTA LC/MS/MS API Vilazodone Antidepressant Human Plasma K 3 EDTA LC/MS/MS API Voriconazole(Sensitive) Antifungal Human Plasma EDTA LC/MS/MS API Voriconazole (Sensitive) Antifungal Human Plasma K 3 EDTA LC/MS/MS API Zidovudine Antiviral Human Plasma EDTA HPLC HPLC-UV Zidovudine (Sensitive) Antiviral Human Plasma Na Heparin HPLC HPLC-UV Zolpidem Insomnia Human Plasma K 3 EDTA LC/MS/MS Premier XE Last Updated: 06 Jan 2016 Page 42 of 43 For more information [email protected]

43 Validated List 424 Zonisamide+ Topiramate + Oxcarbazepine+ Phenytoin Antiepileptic Human Plasma K 2 EDTA LC/MS/MS Premier XE Validated s Library - NCE PD / Immunogenicity Recently Validated Premium s Under Development / Validation Total s 517 Last Updated: 06 Jan 2016 Page 43 of 43 For more information [email protected]

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