Biology and BNCT: in vivo studies
|
|
|
- Flora Bailey
- 9 years ago
- Views:
Transcription
1 Pavia University (Italy) Biology and BNCT: in vivo studies Nano Rosanna Departement of Animal Biology Legnaro, November 17-19, 2009
2 Efficacy of BNCT in liver metastases t
3 PROGETTO TAOrMINA Trattamento Avanzato Organi Mediante Irraggiamento Neutronico e Autotrapianto T. Pinelli *, A.Zonta +, S.Altieri *, S.Barni ++, A.Braghieri *, P.Bruschi *, A. Clerici +, P.Chiari ++, C.Ferrari +, F. Fossati *, R.Nano ++, S.Ngnitejen Tata +, P.Pedroni *, U.Prati +++,G.Ricevuti ++, L.Roveda +,C.Zonta + *INFN e Dipartimento di Fisica Nucleare e Teorica, Università di Pavia + Dipartimento di Chirurgia, Divisione di Chirugia Generale, Università di Pavia e Policlinico S. Matteo, Pavia ++ Dipartimento di Biologia Animale Università di Pavia e Centro di studio per l Istochimica CNR Pavia Dipartimento di Biologia Animale, Università di Pavia e Centro di studio per l Istochimica, CNR Pavia +++ Chirurgia Sperimentale e Tecnologie Chirurgiche Innovative IRCCS Policlinico S. Matteo, Pavia
4 This technique may be applied to different tumor types Japan, U.S.A., Europe: braintumor(gbm) skin melanoma External beams collimated of epithermal neutrons PAVIA Explantable organs: liver lung Irradiation in uniform field of thermal neutrons
5 TRIGA MARK II Nuclear Reactor University of Pavia
6 EXPERIMENTAL STUDY IN VIVO
7 MATERIALS AND METHODS CELL LINE DHD/K12/TRb / CELL LINE HAS BEEN ESTABLISHED FROM A RAT COLON-CARCINOMA CHIMICALLY INDUCED (1,2 dimethylhydrazine ) IN A BD-IX STAIN RATS. THIS LINE WAS SELECTED AND CLONED FOR ITS CAPACITY TO INDUCE PROGRESSIVE AND METASTATIC TUMOURS IN THE SYNGENEIC HOST.
8 DHD/K12/TRb Morphology of the cultured cells stained with MGG M.G.G.
9 Rat liver sample: normal (A) and tumoral (B) A Samples stained with E&E B
10 ELECTRON MICROSCOPE
11 Tumoral cells observed by electronmicroscopy. The cells formed as a nest.
12 FREE TUMORAL CELLS BEFORE IRRADIATION
13 APOPTOTIC TUMORAL CELLS AFTER IRRADIATION
14 Stromal reactivity After transplantation of the liver
15 After transplantation of the liver Collagen bundles
16 Metastatic nodule with apoptotic cells After transplantation t ti of the liver
17 Activated Kupffer Cells
18 Activated Kupffer Cells
19 Example of rat liver metastases The liver metastases are spread in the whole oe organ After BPA infusion It is important to quantify the 10 B concentration In the tumor C T In the normal liver C S T = C T C S
20 Selective absorption of 10 B: neutron autoradiography Histological sample Neutron autoradiography Rat liver
21 Selective absorption of 10 B: neutron autoradiography Histological sample Neutron autoradiography Rat liver
22 METASTASES IMAGING, human liver Healthy liver Liver with metastases 3 mm 9 mm 12 mm Neutron radiography
23 Sequence: sample layers every 40 μm Here we can clearly see the tumor evolution when going deep inside the tissue
24 A very little metastasis All metastases absorb the boron: also those having sizes of a few tenth of mm 16 mm 0.25 mm
25 The first patient (2001) Biopsy during the operation
26 The moment of the exit of the liver from the Triga reactor of Pavia.
27 2002 January 25, the patient visits the nuclear reactor after 37 day of the treatment
28 The first patient (2003) ) Biopsy after BNCT treatment
29 The second patient (2003) Biopsy during the operation
30 The second patient (2003) Biopsy during the operation
31 Post-mortem examination after BNCT treatment (2003)
32 Post-mortem examination after BNCT treatment (2003)
33 Post-mortem examination after BNCT treatment (2003)
34
35 cancer stem cells
36
37 Histiocytic activation following neutron irradiation of boron-enriched rat liver metastases. Nano R, Barni S, Gerzeli G, Pinelli T, Altieri S, Fossati F, Prati U, Roveda L, Zonta A. Ann N Y Acad Sci Dec 15;832: Efficacy of boron neutron capture therapy on liver metastases of colon adenocarcinoma: optical and ultrastructural study in the rat. Nano R, Barni S, Chiari P, Pinelli T, Fossati F, Altieri S, Zonta C, Prati U, Roveda L, Zonta A. Oncol Rep Jan;11(1): Neutron autoradiography imaging of selective boron uptake in human metastatic tumours. Altieri S, Bortolussi S, Bruschi P, Chiari P, Fossati F, Stella S, Prati U, Roveda L, Zonta A, Zonta C, Ferrari C, Clerici A, Nano R, Pinelli T. Appl Radiat Isot Dec;66(12): Epub 2008 May 29 Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases. Bakeine GJ, Di Salvo M, Bortolussi S, Stella S, Bruschi P, Bertolotti A, Nano R, Clerici A, Ferrari C, Zonta C, Marchetti A, Altieri S. Appl Radiat Isot Jul;67(7-8 Suppl):S Epub 2009 Mar 27.
38
Pubblicazioni di Saverio Altieri. Articoli in rivista in stampa
Pubblicazioni di Saverio Altieri Articoli in rivista in stampa 1. Ana Molinari et al., S.Bortolussi et al., Assessing advantages of Sequential Boron Neutron Capture Therapy (BNCT) in an oral cancer model
HADRON THERAPY FOR CANCER TREATMENT
HADRON THERAPY FOR CANCER TREATMENT Seminar presented by Arlene Lennox at Fermilab on Nov 21, 2003 CANCER STAGES LOCAL TUMOR REGIONAL METASTASIS SYSTEMIC DISEASE CANCER TREATMENT SURGERY RADIATION THERAPY
Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.
Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which
Outline. Workup for metastatic breast cancer. Metastatic breast cancer
Metastatic breast cancer Immunostain Update: Diagnosis of metastatic breast carcinoma, emphasizing distinction from GYN primary 1/3 of breast cancer patients will show metastasis 1 st presentation or 20-30
The Di Bella Method (DBM) improves Survival, Objective Response and Performance Status in Breast Cancer
BIT's 4th World Cancer Congress 2011 People s Republic of China Dalian The Di Bella Method (DBM) improves Survival, Objective Response and Performance Status in treated with DBM therapy Retrospective observational
Current Status and Future Direction of Proton Beam Therapy
Current Status and Future Direction of Proton Beam Therapy National Cancer Center Hospital East Division of Radiation Oncology and Particle Therapy Tetsuo Akimoto Comparison of status of particle therapy
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof.
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof. Alberto Riccardi SMALL CELL LUNG CARCINOMA Summary of treatment approach * limited
Future Directions in Cancer Research What does is mean for medical physicists and AAPM?
Future Directions in Cancer Research What does is mean for medical physicists and AAPM? John D. Hazle, Ph.D., FAAPM, FACR President-elect American Association of Physicists in Medicine Professor and Chairman
A 70-year old Man with Pleural Effusion
Mesothelioma Diagnosis: Pitfalls and Latest Updates S Klebe and DW Henderson Recommendations Indisputable malignant cells on cytomorphological criteria which demonstrate a mesothelial phenotype, which
Update on Mesothelioma
November 8, 2012 Update on Mesothelioma Intro incidence and nomenclature Update on Classification Diagnostic specimens Morphologic features Epithelioid Histology Biphasic Histology Immunohistochemical
MAGNETIC RESONANCE AND ITS APPLICATIONS TO THE STUDY OF BIOLOGICAL TISSUES
MAGNETIC RESONANCE AND ITS APPLICATIONS TO THE STUDY OF BRAIN FUNCTION AND OTHER BIOLOGICAL TISSUES G1 Group @ Physics Dept, Sapienza University of Rome Marbilab @ S. Lucia Foundation, Enrico Fermi Centre
The following information is only meant for people who have been diagnosed with advanced non-small cell
Important information for people with advanced non-small cell lung cancer The following information is only meant for people who have been diagnosed with advanced non-small cell lung cancer (NSCLC). NSCLC
The Diagnosis of Cancer in the Pathology Laboratory
The Diagnosis of Cancer in the Pathology Laboratory Dr Edward Sheffield Christmas Select 74 Meeting, Queen s Hotel Cheltenham, 3 rd December 2014 Agenda Overview of the pathology of cancer How specimens
ACUTE MYELOID LEUKEMIA (AML),
1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly
Cancer SBL101. James Gomes School of Biological Sciences Indian Institute of Technology Delhi
Cancer SBL101 James Gomes School of Biological Sciences Indian Institute of Technology Delhi All Figures in this Lecture are taken from 1. Molecular biology of the cell / Bruce Alberts et al., 5th ed.
M. Ugolini 1,2, G. Babini 1,2, G. Baiocco 1,2, D. Cappelletti 1,2, L. Mariotti 1,2, J. Morini 1,2,3 and A. Ottolenghi 1,2
M. Ugolini 1,2, G. Babini 1,2, G. Baiocco 1,2, D. Cappelletti 1,2, L. Mariotti 1,2, J. Morini 1,2,3 and A. Ottolenghi 1,2 1 Department of Physics, University of Pavia, Pavia, Italy 2 Istituto Nazionale
Receptor conversion in distant breast cancer metastases. Breast cancer metastases: A spitting image of their primary?
Receptor conversion in distant breast cancer metastases Breast cancer metastases: A spitting image of their primary? Introduction Breast cancer is the leading cause of female cancer death worldwide (13,000
Male. Female. Death rates from lung cancer in USA
Male Female Death rates from lung cancer in USA Smoking represents an interesting combination of an entrenched industry and a clearly drug-induced cancer Tobacco Use in the US, 1900-2000 5000 100 Per Capita
PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.
PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic
World-first Proton Pencil Beam Scanning System with FDA Clearance
Hitachi Review Vol. 58 (29), No.5 225 World-first Proton Pencil Beam Scanning System with FDA Clearance Completion of Proton Therapy System for MDACC Koji Matsuda Hiroyuki Itami Daishun Chiba Kazuyoshi
PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT
PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT Dott. Francesco Pontieri (*) U.O. di Anatomia Patologica P.O. di Rossano (CS) Dott. Gian Franco Zannoni Anatomia Patologica Facoltà di Medicina e Chirurgia
Cancer is the leading cause of death for Canadians aged 35 to 64 and is also the leading cause of critical illness claims in Canada.
Underwriting cancer In this issue of the Decision, we provide an overview of Canadian cancer statistics and the information we use to make an underwriting decision. The next few issues will deal with specific
National Institute of Public Health
National Institute of Public Health Human resource development and research to improve public health Aiming for a healthy and safe society National Institute of Public Health website: http://www.niph.go.jp/index_en.html
False positive PET in lymphoma
False positive PET in lymphoma Thomas Krause Introduction and conclusion 2 3 Introduction 4 FDG-PET in staging of lymphoma 34 studies with 2227 Patients CT FDG-PET Sensitivity 63 % 89 % (58%-100%) (63%-100%)
RADIATION THERAPY FOR LYMPHOMA. Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY
RADIATION THERAPY FOR Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE AMERICAN SOCIETY FOR RADIATION ONCOLOGY FACTS ABOUT The lymphatic system is a network of tiny vessels extending
Pathophysiology of bone metastasis : how does it apply to pain treatment in palliative care? JP Vuillez, Grenoble, France
Pathophysiology of bone metastasis : how does it apply to pain treatment in palliative care? JP Vuillez, Grenoble, France Bone metastases 70 % of prostate and breast cancers 30 % of lung, bladder and thyroid
Advanced Radiation Therapy of Cancer by Proton Beam
March 20th, 2014 Advanced Radiation Therapy of Cancer by Proton Beam Fukui Prefectural Hospital Proton Therapy Center Yamamoto, Kazutaka Wave (electromagnetic wave) IR (Ionizing) Radiation 700 400 350~100
.org. Metastatic Bone Disease. Description
Metastatic Bone Disease Page ( 1 ) Cancer that begins in an organ, such as the lungs, breast, or prostate, and then spreads to bone is called metastatic bone disease (MBD). More than 1.2 million new cancer
Biomedical Optics Theory
Introduction Biomedical Optics Theory Diffuse reflectance spectroscopy (DRS) and Laser Doppler Flowmetry (LDF) are booth optical techniques that can quantify a number of microcirculatory parameters. Prof
Proton Therapy in Singapore
Proton Therapy in Singapore Kam-Weng Fong, MD Radiation Oncologist Chair, Proton Therapy Committee National Cancer Center, Singapore 1 st IAS-CERN Workshop Nanyang Technological University Singapore 25-27
CytoSelect 48-Well Cell Adhesion Assay (ECM Array, Colorimetric Format)
Product Manual CytoSelect 48-Well Cell Adhesion Assay (ECM Array, Colorimetric Format) Catalog Number CBA-070 CBA-070-5 48 assays 5 x 48 assays FOR RESEARCH USE ONLY Not for use in diagnostic procedures
Title: Immunohistochemical staining of radixin and moesin in prostatic adenocarcinoma
Author's response to reviews Title: Immunohistochemical staining of radixin and moesin in prostatic adenocarcinoma Authors: Tanner L Bartholow ([email protected]) Uma R Chandran ([email protected])
Histopathology of Colorectal Cancer after Neoadjuvant Chemoradiation Therapy
The Open Pathology Journal, 2009, 3, 91-98 91 Open Access Histopathology of Colorectal Cancer after Neoadjuvant Chemoradiation Therapy Maura O Neil * and Ivan Damjanov Department of Pathology and Laboratory
Brain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them.
Brain Cancer Introduction Brain tumors are not rare. Thousands of people are diagnosed every year with tumors of the brain and the rest of the nervous system. The diagnosis and treatment of brain tumors
Implementation Date: April 2015 Clinical Operations
National Imaging Associates, Inc. Clinical guideline PROSTATE CANCER Original Date: March 2011 Page 1 of 5 Radiation Oncology Last Review Date: March 2015 Guideline Number: NIA_CG_124 Last Revised Date:
Multiple Myeloma Understanding your diagnosis
Multiple Myeloma Understanding your diagnosis Multiple Myeloma Understanding your diagnosis When you first hear that you have cancer you may feel alone and afraid. You may be overwhelmed by the large amount
Mesothelioma. 1995-2013, The Patient Education Institute, Inc. www.x-plain.com ocft0101 Last reviewed: 03/21/2013 1
Mesothelioma Introduction Mesothelioma is a type of cancer. It starts in the tissue that lines your lungs, stomach, heart, and other organs. This tissue is called mesothelium. Most people who get this
Targeted Therapy What the Surgeon Needs to Know
Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures
Frozen Section Diagnosis
Frozen Section Diagnosis Dr Catherine M Corbishley Honorary Consultant Histopathologist St George s Healthcare NHS Trust and lead examiner final FRCPath Practical 2008-2011 Frozen Section Diagnosis The
MOLOGEN AG. Q1 Results 2015 Conference Call Dr. Matthias Schroff Chief Executive Officer. Berlin, 12 May 2015
Q1 Results 2015 Conference Call Dr. Matthias Schroff Chief Executive Officer Berlin, 12 May 2015 V1-6 Disclaimer Certain statements in this presentation contain formulations or terms referring to the future
Cambia l algoritmo terapeutico
X Seminario I.T.M.O. Neoplasie a bassa incidenza Istituto di Oncologia Policlinico di Monza Monza 07 Maggio2012? Cambia l algoritmo terapeutico Michele Maio Medical Oncology and Immunotherapy, Department
Skin cancer Patient information
Skin cancer Patient information What is cancer? The human body is made up of billions of cells. In healthy people, cells grow, divide and die. New cells constantly replace old ones in an orderly way. This
Treating Melanoma S kin Cancer A Quick Guide
Treating Melanoma Skin Cancer A Quick Guide Contents This is a brief summary of the information on Treating melanoma skin cancer from our website. You will find more detailed information on the website.
Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain
Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Second Opinion in Breast Pathology Usually requested when a patient is referred
CancerStemCell Markers in Lung Cancers: Proofsof. Reservations. Lourdes Cortes-Dericks, PhD University of Hamburg Hamburg, Germany
CancerStemCell Markers in Lung Cancers: Proofsof ConceptsandSome Reservations Lourdes Cortes-Dericks, PhD University of Hamburg Hamburg, Germany Lung cancer: highest death rate and poorest patient survival
Colon and Rectal Cancer
Colon and Rectal Cancer What is colon or rectal cancer? Colon or rectal cancer is the growth of abnormal cells in your large intestine, which is also called the large bowel. The colon is the last 5 feet
What You Need to Know About Lung Cancer Immunotherapy
What You Need to Know About Lung Cancer Immunotherapy Lung.org/immunotherapy What is immunotherapy? Immunotherapy for cancer, sometimes called immune-oncology, is a type of medicine that treats cancer
H. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland School of Medicine Baltimore, Md
Major Advances in Cancer Prevention, Diagnosis and Treatment~ Why Mesothelioma Leads the Way H. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland
Report series: General cancer information
Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for
EFFECTS OF ELECTROMAGNETIC RADIATION FROM MOBILE PHONES AND CASE STUDIES OF COMPUTATIONAL MODELS FOR CALCULATING SAR DISTRIBUTION IN HUMAN BODY Settapong Malisuwan National Broadcasting and Telecommunications
What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function:
Cancer is a genetic disease: Inherited cancer Sporadic cancer What is Cancer? Cancer typically involves a change in gene expression/function: Qualitative change Quantitative change Any cancer causing genetic
ST JOSEPH REGIONAL HEALTH CENTER LUNG CANCER ANALYSIS Incidence, Diagnosis, Treatment and Survival
ST JOSEPH REGIONAL HEALTH CENTER LUNG CANCER ANALYSIS Incidence, Diagnosis, Treatment and Survival It is logical that the Cancer Program Committee choose to review the Lung Site, as Lung is the second
Understanding Metastatic Disease
Supported by an unrestricted educational grant from Pfizer Understanding Metastatic Disease Metastatic disease or metastases are phrases that mean the same as Secondary cancer. This means that the cancer
The develpemental origin of mesothelium
Mesothelioma Tallinn 14.12.06 Henrik Wolff Finnish Institute of Occupational Health The develpemental origin of mesothelium Mesodermal cavities (pleura, peritoneum and pericardium ) are lined with mesenchymal
How CanCer becomes critical in the claims
How CanCer becomes critical in the claims arena Cancer is a disease in which cells in your body grow in an uncontrolled way and form a lump called a tumour. In a healthy individual cells grow and reproduce
Current Status and Perspectives of Radiation Therapy for Breast Cancer
Breast Cancer Current Status and Perspectives of Radiation Therapy for Breast Cancer JMAJ 45(10): 434 439, 2002 Masahiro HIRAOKA, Masaki KOKUBO, Chikako YAMAMOTO and Michihide MITSUMORI Department of Therapeutic
Cancer: DNA Synthesis, Mitosis, and Meiosis
Chapter 5 Cancer: DNA Synthesis, Mitosis, and Meiosis Copyright 2007 Pearson Copyright Prentice Hall, 2007 Inc. Pearson Prentice Hall, Inc. 1 What Is Cancer? Benign tumors do not invade surrounding tissue
Melanoma The Skin Understanding Cancer
Melanoma A form of cancer that begins in melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or
Metastasis. Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA [email protected]
Metastasis Ma Hongbao 1, Margaret Ma 2, Yang Yan 1 1 Brookdale Hospital, Brooklyn, New York 11212, USA; 2 Cambridge, MA 02138, USA [email protected] Abstract: Cancer begins when cells in a part of the body
UC DAVIS CANCER CENTER
UC DAVIS CANCER CENTER Endoscopic Enhancement by a Spectroscopic Cancer Detection System Ralph W. devere White, M.D. Professor and Chairman, Department of Urology Director, UC Davis Cancer Center University
MEDICAL BREAKTHROUGHS RESEARCH SUMMARY
MEDICAL BREAKTHROUGHS RESEARCH SUMMARY TOPIC: Training the Body to Fight Melanoma REPORT: 3823 BACKGROUND: Melanoma is the most dangerous form of skin cancer that can be hard to treat and fatal if not
Lung Cancer: Diagnosis, Staging and Treatment
PATIENT EDUCATION patienteducation.osumc.edu Lung Cancer: Diagnosis, Staging and Treatment Cancer begins in our cells. Cells are the building blocks of our tissues. Tissues make up the organs of the body.
Newsletter. WntResearch AB, Medeon Science Park, Per Albin Hanssons väg 41, 205 12 Malmö, Sweden. Primary Objective:
Newsletter This resume of the results from the phase 1 study with Foxy-5 is based on clinical and laboratory data from the study, and these data have now been locked into the database. The full report
Chapter 2 Staging of Breast Cancer
Chapter 2 Staging of Breast Cancer Zeynep Ozsaran and Senem Demirci Alanyalı 2.1 Introduction Five decades ago, Denoix et al. proposed classification system (tumor node metastasis [TNM]) based on the dissemination
Our Facility. Advanced clinical center with the newest and highly exact technology for treatment of patients with cancer pencil beam
PTC Czech The main goal of radiotherapy is to irreversibly damage tumor cells, whereas the cells of healthy tissue are damaged only reversibly or not at all. Proton therapy currently comes closest to this
The Ontario Cancer Registry moves to the 21 st Century
The Ontario Cancer Registry moves to the 21 st Century Rebuilding the OCR Public Health Ontario Grand Rounds Oct. 14, 2014 Diane Nishri, MSc Mary Jane King, MPH, CTR Outline 1. What is the Ontario Cancer
BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome. Thomas Wiesner
BAP1 germline mutations A new Cutaneous Nevus Melanoma Syndrome Thomas Wiesner Disclosure Listed as co-inventor US patent application US 61/463,389 BAP1 mutational analysis in determining susceptibility
Ovarian tumors Ancillary methods
Ovarian tumors Ancillary methods Ovarian tumor course Oslo, 24-25/11/14 Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Division of
THYROID CANCER. I. Introduction
THYROID CANCER I. Introduction There are over 11,000 new cases of thyroid cancer each year in the US. Females are more likely to have thyroid cancer than men by a ratio of 3:1, and it is more common in
Your Guide to Express Critical Illness Insurance Definitions
Your Guide to Express Critical Illness Insurance Definitions Your Guide to EXPRESS Critical Illness Insurance Definitions This guide to critical illness definitions will help you understand the illnesses
Stem Cell Quick Guide: Stem Cell Basics
Stem Cell Quick Guide: Stem Cell Basics What is a Stem Cell? Stem cells are the starting point from which the rest of the body grows. The adult human body is made up of hundreds of millions of different
Targeted Therapies in Lung Cancer
Targeted Therapies in Lung Cancer I Edited by: Simona Carnio Thoracic Oncology Division - St Luigi Hospital Orbassano (TO) - Italy Silvia Novello Department of Oncology - University of Torino - Italy Why
Ching-Yao Yang, Yu-Wen Tien
Ching-Yao Yang, Yu-Wen Tien Division of General Surgery, Department of Surgery, National Taiwan University Hospital Oct-30-2010 Pancreatic NET have poorer prognosis when presence of liver metastases at
Prostate Cancer. Treatments as unique as you are
Prostate Cancer Treatments as unique as you are UCLA Prostate Cancer Program Prostate cancer is the second most common cancer among men. The UCLA Prostate Cancer Program brings together the elements essential
MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY
MALIGNANT MESOTHELIOMA CLASSIFICATION MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo,
Glioblastoma (cancer affecting the brain) A guide for journalists on glioblastoma and its treatment
Glioblastoma (cancer affecting the brain) A guide for journalists on glioblastoma and its treatment Section 1 Glioblastoma Section 2 Epidemiology and prognosis Section 3 Treatment Contents Contents 2 3
Avastin: Glossary of key terms
Avastin: Glossary of key terms Adenocarcinoma Adenoma Adjuvant therapy Angiogenesis Anti-angiogenics Antibody Antigen Avastin (bevacizumab) Benign A form of carcinoma that originates in glandular tissue.
Immunohistochemistry on cytology specimens from pleural and peritoneal fluid
Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Dr Naveena Singh Consultant Pathologist Bart health NHS Trust London United Kingdom Disclosures and Acknowledgements I have
Kidney Cancer OVERVIEW
Kidney Cancer OVERVIEW Kidney cancer is the third most common genitourinary cancer in adults. There are approximately 54,000 new cancer cases each year in the United States, and the incidence of kidney
Pancreatic Cancer Understanding your diagnosis
Pancreatic Cancer Understanding your diagnosis Let s Make Cancer History 1 888 939-3333 cancer.ca Pancreatic Cancer Understanding your diagnosis When you first hear that you have cancer you may feel alone
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES.
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES. Radiation Oncology Sidney Kimmel Cancer Center at Johns Hopkins Last
Frequently Asked Questions About Ovarian Cancer
Media Contact: Gerri Gomez Howard Cell: 303-748-3933 [email protected] Frequently Asked Questions About Ovarian Cancer What is ovarian cancer? Ovarian cancer is a cancer that forms in tissues
Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background
Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the
The recommendations made throughout this book are by the National Health and Medical Research Council (NHMRC).
INTRODUCTION This book has been prepared for people with bowel cancer, their families and friends. The first section is for people with bowel cancer, and is intended to help you understand what bowel cancer
Understanding Cancer Basics
Goals & Objectives Section 1 Understanding GOALS Participants will learn how a cancer diagnosis is made and become familiar with common medical words used when describing cancer. Participants will be able
Cytotoxic and Biotherapies Credentialing Programme Module 2
Cytotoxic and Biotherapies Credentialing Programme Module 2 1. The Cell Cycle 2. Cancer Therapies 3. Adjunctive Therapies On completion of this module the RN will State the difference between a normal
YOUR LUNG CANCER PATHOLOGY REPORT
UNDERSTANDING YOUR LUNG CANCER PATHOLOGY REPORT 1-800-298-2436 LungCancerAlliance.org A GUIDE FOR THE PATIENT 1 CONTENTS What is a Pathology Report?...3 The Basics...4 Sections of a Pathology Report...7
Pulsed laser deposition of organic materials
Pulsed laser deposition of organic materials PhD theses Gabriella Kecskeméti Department of Optics and Quantum Electronics University of Szeged Supervisor: Dr. Béla Hopp senior research fellow Department
Lung Cancer Treatment Guidelines
Updated June 2014 Derived and updated by consensus of members of the Providence Thoracic Oncology Program with the aid of evidence-based National Comprehensive Cancer Network (NCCN) national guidelines,
Development of on line monitor detectors used for clinical routine in proton and ion therapy
Development of on line monitor detectors used for clinical routine in proton and ion therapy A. Ansarinejad Torino, february 8 th, 2010 Overview Hadrontherapy CNAO Project Monitor system: Part1:preliminary