Prevention and Intervention Strategies in Acute Pancreatitis

Transcription

1 Prevention and Intervention Strategies in Acute Pancreatitis Marc G.H. Besselink

2 Prevention and Intervention Strategies in Acute Pancreatitis Thesis, Utrecht University, the Netherlands Copyright : 2008 by M.G.H. Besselink, the Netherlands ISBN: Printed by: Gildeprint Drukkerijen B.V., Enschede Lay-out: Gildeprint Drukkerijen B.V., Enschede and Multimedia, UMC Utrecht Cover: 1893 edition of the Henley Royal Regatta (unknown artist), River & Rowing Museum, Henley on Thames, England (with permission) A rowing regatta provides a striking metaphor for performing multicentre trials. The rowers (the researchers) have to closely coordinate their movements in order to make good progress but also depend on their co-workers (spectator boats) and sponsors (large house boats) in providing them with the conditions needed for rowing an optimal race (multicentre trial). In beautiful contrast with the studies described in this thesis, spectator boats on the Henley Royal Regatta course were a regular hazard for competing crews.

3 Prevention and Intervention Strategies in Acute Pancreatitis Preventie- en Interventiestrategieën in Acute Pancreatitis (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof.dr. J.C. Stoof, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op vrijdag 19 september 2008 des middags te 4.15 uur door Marc Gerard Herman Besselink geboren op 19 april 1976 te Hengelo (Ov.)

4 Promotoren Prof.dr. H.G. Gooszen Prof.dr. L.M.A. Akkermans Co-promotoren Dr. M.A. Boermeester Dr. K.J. van Erpecum The research described in this thesis was financially supported by: SENTER, an agency of the Dutch Ministry of Economic Affairs (grant number TSGE3109) and The Netherlands Organization for Health Research and Development (ZonMw, AGIKO grant number ). The printing of this thesis was financially supported by: De Alvleeskliervereniging, Assen; Winclove Bio Industries BV, Amsterdam; Chirurgisch Fonds Heelkunde, Utrecht; J.E. Jurriaanse Stichting, Rotterdam; AstraZeneca, Zoetermeer; Nycomed BV, Hoofddorp; Novartis Oncology, Arnhem; Bennebroek Consultancy, Alphen aan den Rijn; Huijskens & Istha, Amsterdam; Covidien Nederland BV, Zaltbommel; KCI-Medical BV, Houten; EuroTec B.V. Roosendaal; Gut Flora Foundation, Bilthoven. The sponsors, who are gratefully acknowledged, had no involvement in any stage of the study design, data collection, data-analysis, interpretation of the study results or the decision to publish study results.

5 Aan mijn ouders Voor Carlien

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7 CONTENTS 1. General introduction and thesis outline 9 PART A Prevention Strategies 2. Ursodeoxycholic acid exerts no beneficial effect in patients with 21 symptomatic gallstones awaiting cholecystectomy: a randomised, double-blind, placebo-controlled trial Hepatology Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, 41 double-blind, placebo-controlled trial Lancet Intestinal barrier dysfunction in a randomised placebo-controlled trial of 65 probiotic prophylaxis in acute pancreatitis Submitted 5. Timing and impact of infections in acute pancreatitis 85 Submitted PART B Intervention Strategies 6. Surgical intervention in patients with necrotizing pancreatitis 103 British Journal of Surgery Describing computed tomography findings in acute necrotizing pancreatitis 119 with the Atlanta classification: an interobserver agreement study Pancreas Feasibility of minimally invasive approaches in patients with infected 131 necrotizing pancreatitis British Journal of Surgery Timing of surgical intervention in necrotizing pancreatitis 141 Archives of Surgery Early endoscopic retrograde cholangiopancreatography vs conservative 161 management in acute biliary pancreatitis without cholangitis: a meta-analysis of randomised trials Annals of Surgery 2008

8 11. General discussion and summary Summary in Dutch (Nederlandse samenvatting) 191 Acknowledgements (Dankwoord) 201 Curriculum Vitae 209 List of publications 210 Review committee 217

9 List of relevant publications 23. Bollen TL, van Santvoort HC, Besselink MG, van Ramshorst B, van Es HW, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Intense adrenal enhancement in patients with acute pancreatitis and early organ failure. Emerg Radiol 2007; 14: Petrov MS, van Santvoort HC, Besselink MG, Cirkel GA, Brink MA, Gooszen HG. Oral Refeeding After Onset of Acute Pancreatitis: A Review of Literature. Am J Gastroenterol. 2007; 102: Besselink MG, Bollen TL, Scheffer RC, Weusten BL, Timmer R, Wiezer RM, van Ramshorst B. Rupture of infected peripancreatic necrosis to the peritoneal cavity with fatal outcome. Pancreas 2007; 34: Besselink MG, van Santvoort HC, Schaapherder AF, van Ramshorst B, van Goor H, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Feasibility of minimally invasive approaches in patients with infected necrotizing pancreatitis. Br J Surg 2007; 94: Besselink MG, van Santvoort HC, Witteman BJ, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Management of severe acute pancreatitis: it s all about timing. Curr Opin Crit Care 2007; 13: Schiphorst AH, Besselink MGH, Venneman NG, Go PM. Symptomatic gallstone disease: an indication for surgery. Ned Tijdschr Geneeskd 2006; 150: Besselink MG, van Santvoort HC, Bollen TL, van Leeuwen MS, Lameris HS, van der Jagt EJ, Strijk SP, Buskens E, Freeny PC, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Describing computed tomography findings in acute necrotizing pancreatitis with the Atlanta classification: an interobserver agreement study. Pancreas 2006; 33: van Santvoort HC, Besselink MGH, Cirkel GA, Gooszen HG for the Dutch Acute Pancreatitis Study Group. A nationwide Dutch study into the optimal treatment of patients with infected necrotizing pancreatitis: the PANTER trial. Ned Tijdschr Geneesk 2006; 150:

10 Chapter Venneman NG, Besselink MG, Keulemans YC, vanberge-henegouwen GP, Boermeester MA, Broeders IA, Go PM, van Erpecum KJ. Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy. Hepatology 2006; 43: Besselink MG, van Santvoort HC, Buskens E, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Evidence-based treatment of acute pancreatitis: antibiotic prophylaxis in necrotizing pancreatitis. Ann Surg 2006; 244: Besselink MG, van Santvoort HC, Nieuwenhuijs VB, Boermeester MA, Bollen TL, Buskens E, Dejong CH, van Eijck CH, van Goor H, Hofker SS, Lameris HS, van Leeuwen MS, Ploeg RJ, van Ramshorst B, Schaapherder AF, Cuesta MA, Consten EC, Gouma DJ, van der Harst E, Hesselink EJ, Houdijk LP, Karsten TM, van Laarhoven CJ, Pierie JP, Rosman C, Spillenaar Bilgen EJ, Timmer R, van der Tweel I, de Wit RJ, Witteman BJ, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Minimally invasive step-up approach vs maximal necrosectomy in patients with acute necrotizing pancreatitis (PANTER trial): design and rationale of a randomised controlled multicentre trial [ISRCTN ]. BMC Surg 2006; 6: van Santvoort HC, Besselink MG, van Minnen LP, Timmerman HM, Akkermans LM, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Potential role for probiotics in the prevention of infectious complications during acute pancreatitis. Ned Tijdschr Geneeskd 2006; 150: Besselink MG, de Bruijn MT, Rutten JP, Boermeester MA, Hofker HS, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Surgical intervention in patients with necrotizing pancreatitis. Br J Surg 2006; 93: Besselink MG, Bollen TL, Boermeester MA, van Ramshorst B, van Leeuwen MS, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Timing and choice of intervention in necrotizing pancreatitis. Ned Tijdschr Geneeskd 2005; 149: Besselink MG, Gooszen HG, Buskens E. Clinical trial registration and the ICMJE. JAMA 2005; 293:

11 List of relevant publications 38. Besselink MG, Timmerman HM, Ridwan BU, Akkermans LM and Gooszen HG. Lactobacilli in necrotizing pancreatitis. Pancreatology 2005; 5: Besselink MG, Kroeze J. Gallstone Ileus. Mayo Clin Proc 2005: 80: Besselink MG, van Minnen LP, Bosscha K, van Erpecum KJ, Gooszen HG. Beneficial effects of ERCP and papillotomy in predicted severe acute pancreatitis. Hepatogastroenterology 2005; 52: Besselink MG, Timmerman HM, Buskens E, Nieuwenhuijs VB, Akkermans LM, Gooszen HG for the Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicentre trial [ISRCTN ]. BMC Surg 2004; 4: Nieuwenhuijs VB, Besselink MG, van Minnen LP, Gooszen HG. Surgical management of acute necrotizing pancreatitis: a 13-year experience and a systematic review. Scand J Gastroenterol Suppl 2003; 38: van Minnen LP, Besselink MG, Bosscha K, van Leeuwen MS, Schipper ME, Gooszen HG. Colonic involvement in acute pancreatitis. A retrospective study of 16 patients. Dig Surg 2004; 21:

12 Chapter 12 REVIEW COMMITTEE Prof.dr. Y. van der Graaf Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht, the Netherlands Prof.dr. M.J.M. Bonten Department of Medical Microbiology University Medical Center Utrecht Utrecht, the Netherlands Prof.dr. M.G. Sarr Department of Gastroenterologic and General Surgery Mayo Clinic Rochester, United States Prof.dr. C.H.C. Dejong Department of Surgery Maastricht University Medical Center Maastricht, the Netherlands Prof.dr. R.J. Ploeg Department of Surgery University Medical Center Groningen Groningen, the Netherlands Further members of the opposition committee: Prof.dr. K.D. Horvath Department of Surgery University of Washington Seattle, United States Prof.dr. I.H.M. Borel Rinkes Department of Surgery University Medical Center Utrecht Utrecht, the Netherlands 217

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