Targeted therapy in oncology: mechanisms and toxicity
|
|
|
- Toby O’Neal’
- 8 years ago
- Views:
Transcription
1 Targeted therapy in oncology: mechanisms and toxicity Neeltje Steeghs
2 Targeted therapy in oncology: mechanisms and toxicity ISBN/EAN: Lay-out: Grafisch bureau Christine van der Ven, Voorschoten Printed by: Gildeprint Drukkerijen, Enschede Financial support for printing this thesis by SKOL (Stichting Klinische Oncologie Leiden), AZL Onderzoeks- en Ontwikkelingskrediet Apotheek, Abbott, Amgen, Astra Zeneca, Bayer Pharmaceuticals, Bristol-Myers Squibb, GlaxoSmithKline, Janssen-Cilag, Merck, Merck Sharp & Dohme, Nerviano MS, Novartis, Pfizer, Sanofi-Aventis, and Wyeth is gratefully acknowledged 2009 Neeltje Steeghs, Leiderdorp, The Netherlands
3 Targeted therapy in oncology: mechanisms and toxicity Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op dinsdag 24 november 2009 klokke uur door Neeltje Steeghs geboren te Breda in 1977
4 PROMOTIECOMMISSIE Promotores: Prof. Dr. J.W.R. Nortier Prof. Dr. H.-J. Guchelaar Copromotor: Dr. A.J. Gelderblom Leden: Prof. Dr. M. Danhof Prof. Dr. A.J. Rabelink Prof. Dr. J.H.M. Schellens
5 CONTENTS Chapter 1 General introduction and outline of the thesis... 7 Chapter 2 Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments... Ann Surg Oncol Feb;14(2): Chapter 3 EGFR and ERBB2 expression in sarcomas: the search for new treatment options Chapter 4 A phase I dose escalation study of telatinib (BAY ), a tyrosine kinase inhibitor of VEGFR-2, VEGFR-3, PDGFR-β and c-kit, in patients with advanced or metastatic solid tumors... J Clin Oncol. 2009;27(15): Chapter 5 Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors... Submitted 63 Chapter 6 Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor... Clin Cancer Res Jun 1;14(11): Chapter 7 Reversibility of capillary density after discontinuation of bevacizumab treatment... Ann Oncol, in press 93 Chapter 8 Phase I dose escalation study of sunitinib in combination with ifosfamide... Study ongoing 107 Chapter 9 A phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor PHA in patients with advanced or metastatic solid tumors... J Clin Oncol, in press 125
6 Chapter 10 Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor PHA Submitted 145 Chapter 11 General discussion Summary Samenvatting Nawoord Curriculum vitae Publications
7 1General introduction and outline of the thesis
8 Chapter 1 8
9 Chapter
10 List of publications
11 Chapter
12 List of publications Full text articles Steeghs N, de Jongh FE, Sillevis Smitt PA, van den Bent MJ. Cisplatin-induced encephalopathy and seizures. Anticancer Drugs. 2003;14(6): Review. Steeghs N, Goekoop RJ, Niessen RWLM, Jonkers GJPM, Dik H. C-reactive protein and D-dimer with clinical probability score in the exclusion of pulmonary embolism. Br J Haematol. 2005;130(4): Steeghs N, Huizinga TWJ, Dik H. Bilateral hydropneumothoraces in a patient with pulmonary rheumatoid nodules during treatment with methotrexate. Ann Rheum Dis. 2005;64(11): Goekoop RJ, Steeghs N, Niessen RW, Jonkers GJ, Dik H, Castel A, Werker-van Gelder L, Vlasveld LT, van Klink RC, Planken EV, Huisman MV. Simple and safe exclusion of pulmonary embolism in outpatients using quantitative D-dimer and Wells simplified decision rule. Thromb Haemost. 2007;97(1): Steeghs N, Nortier JW, Gelderblom, H. Small Molecule Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors: An Update of Recent Developments. Ann Surg Oncol. 2007;14(2): Steeghs N, Gelderblom H, op t Roodt J, Christensen O, Rajagopalan P, Hovens M, Putter H, Rabelink TJ, de Koning E. Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res. 2008;14(11): Steeghs N. Angiogenesis: A Key Target in Oncology. Angiogenese journaal Eskens FALM, Steeghs N, Verweij J, Bloem JL, Christensen O, van Doorn L, Ouwerkerk J, de Jonge MJA, Nortier JWR, Kraetzschmar J, Rajagopalan P, Gelderblom H. A phase I dose escalation study of telatinib (BAY ), a tyrosine kinase inhibitor of VEGFR-2, VEGFR-3, PDGFR-β and c-kit, in patients with advanced or metastatic solid tumors. J Clin Oncol. 2009;27(15): Steeghs N, Eskens FALM, Gelderblom H, Verweij J, Nortier JWR, Ouwerkerk J, van Noort C, Mariani M, Spinelli R, Carpinelli P, Laffranchi B, de Jonge MJA. A phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor PHA in patients with advanced or metastatic solid tumors. J Clin Oncol, in press 189
13 Chapter 11 Steeghs N, Gelderblom H, Wessels JAM, Eskens FALM, de Bont N, Nortier JWR, Guchelaar H-J. Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors. Submitted Steeghs N, Mathijssen RHJ, Wessels JAM, de Graan A-J, van der Straaten T, Mariani M, Laffranchi B, Comis S, de Jonge MJA, Gelderblom H, Guchelaar H-J. Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib. Submitted Steeghs N, Rabelink TJ, op t Roodt J, Batman E, Cluitmans FHM, Weijl NI, de Koning E, Gelderblom H. Reversibility of capillary density after discontinuation of bevacizumab treatment. Ann Oncol, in press 190
14 List of publications Abstracts Tesselaar M, Steeghs N, Rosendaal F, Osanto S. Incidence of thrombosis in gastro-esophageal cancer; a cohort study of 761 patients. J Clin Oncol. 2004; Vol 22, No 14S: Steeghs N, Hovens MMC, Rabelink AJ, de Koning E, op t Roodt J, Matthys A, Christensen O, Gelderblom H VEGFR2 blokkade in patiënten met solide tumoren: mechanismen van hypertensie en effecten op vaatfuncties. Abstracts of the Internistendagen Maastricht, Netherlands, April, Steeghs N, Hovens MMC, Rabelink AJ, de Koning E, op t Roodt J, Matthys A, Christensen O, Gelderblom H. VEGFR-2 Blockade in Patients with Solid Tumors: Mechanism of Hypertension and Effects on Vascular Function. J Clin Oncol. 2006; Vol 24, No 18S: H. Gelderblom, J. Verweij, N. Steeghs, A. Van Erkel, L. Van Doorn, J. Ouwerkerk, P. Rajagopalan, A. Matthys, D. Voliotis, F. Eskens. Phase I, safety, pharmacokinetic and biomarker study of BAY , an oral VEGFR-2 inhibitor, in a continuous schedule in patients with advanced solid tumors. J Clin Oncol. 2006; Vol 24, No 18S: Gelderblom H, Verweij J, Steeghs N, de Koning EJP, van Erkel A, van Doorn L, Zuehlsdorf M, Rajagopalan P, Christensen O, Eskens F. Phase I, safety, pharmacokinetic and biomarker study of telatinib (BAY ), an oral VEGFR-2 inhibitor, in a continous schedule in patients with advanced solid tumors. Eur J Cancer Supplements Vol 4, No.12, page 25. M. De Jonge, N. Steeghs, J. Verweij, J.W.R. Nortier, F. Eskens, J. Ouwerkerk, C. Van Noort, P. Carpinelli, R. Spinelli, F. Bologna, H. Gelderblom. Phase I dose escalation study of the aurora kinase inhibitor PHA administered as a 6hour infusion on days 1, 8 and 15 every 4 weeks in patients with advanced metastatic solid tumors. Eur J Cancer Supplements Vol 4, No.12, page 12. M. De Jonge, N. Steeghs, J. Verweij, J.W.R. Nortier, F. Eskens, J. Ouwerkerk, C. Van Noort, P. Carpinelli, R. Spinelli, F. Bologna, H. Gelderblom. Phase I dose escalation study of the aurora kinase inhibitor PHA administered as a 6 hour infusion on days 1, 8 and 15 every 4 weeks in patients with advanced metastatic solid tumors. J Clin Oncol. 2008; Vol 26, No 18S:
15 Steeghs N, Rabelink TJ, op t Roodt J, de Koning E, Gelderblom H. Bevacizumab-related hypertension: Search for underlying mechanisms. J Clin Oncol. 2009; Vol 27, suppl: e Hamberg P, Steeghs N, Loos WJ, van der Biessen DJ, den Hollander MA, Tascilar M, Verweij J, Gelderblom H, Sleijfer S. Phase I safety and pharmacokinetic (PK) study of sunitinib (S) in combination with ifosfamide (I) in patients (pts) with advanced solid tumors (STs). J Clin Oncol. 2009; Vol 27, suppl: e13520.
Opening the psychological black box in genetic counseling
Opening the psychological black box in genetic counseling A counselee-oriented, integrative approach on the impact of DNA-testing for breast and ovarian cancer on the lives of counselees Joël Vos 1 2 Opening
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population. Carel Jan Willem Borleffs
Implantable Cardioverter Defibrillator Treatment: Benefits and Pitfalls in the Currently Indicated Population Carel Jan Willem Borleffs The studies described in this thesis were performed at the Department
Item Analysis of Single-Peaked Response Data. The Psychometric Evaluation of Bipolar Measurement Scales
Item Analysis of Single-Peaked Response Data The Psychometric Evaluation of Bipolar Measurement Scales Acknowledgement Financial support for the printing costs of this thesis was provided by the Developmental
Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations. Nancy J. Senff
Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations Nancy J. Senff The studies described in this thesis were financially supported by a grant from the Dutch Cancer
Cover Page. The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/38352 holds various files of this Leiden University dissertation. Author: Font Vivanco, David Title: The rebound effect through industrial ecology s eyes
Small artery tone under control of the endothelium
Small artery tone under control of the endothelium On the importance of EDHF and myogenic tone in organ (dys)function Simone K. Gschwend Publication of this thesis was supported by generous contributions
M.A.Lips. Copyright 2014, M.A.Lips, Amsterdam, the Netherlands
Roux-en-Y Gastric Bypass and Calorie Restriction: Differences and Similarities of Endocrine and Metabolic Effects in Obesity and Type 2 Diabetes Mellitus Mirjam Anne Lips Roux-en-Y Gastric Bypass and Calorie
Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Author: Tabak, F.C. Title: Towards high-speed scanning tunneling microscopy Issue Date:
New Edge. Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN
New Edge Technology and Spirituality in the San Francisco Bay Area DORIEN ZANDBERGEN Produced by F&N Boekservice 2011, Dorien Zandbergen, Leiden, The Netherlands Front and back covers designed by Lise
Style Characterization of Machine Printed Texts
Style Characterization of Machine Printed Texts Andrew D. Bagdanov This book is typeset by the author using L A TEX2 ε. The main body of the text is set using the Computer Modern family of fonts. The images
Childhood onset MS and MS during Pregnancy
Childhood onset MS and MS during Pregnancy Rinze Frederik Neuteboom -The studies in this thesis were financially supported by Stichting MS Research -Financial support for publication: Erasmus University
Students Conceptions of Constructivist Learning. Sofie Loyens
Students Conceptions of Constructivist Learning Sofie Loyens ISBN 978-90-8559-275-4 Copyright 2007 S.M.M. Loyens All rights reserved. No part of this thesis may be reproduced or transmitted in any form,
Changes in Pilot Control Behaviour across Stewart Platform Motion Systems
Changes in Pilot Control Behaviour across Stewart Platform Motion Systems PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus prof.
Understanding Crowd Behaviour Simulating Situated Individuals
Understanding Crowd Behaviour Simulating Situated Individuals Nanda Wijermans The research reported in this thesis was funded by the Netherlands Ministry of Defence ("DO-AIO" fund contract no TM-12). The
Cover Page. The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/36077 holds various files of this Leiden University dissertation Author: Boekholt, Tjarda Title: Chaotic dynamics in N-body systems Issue Date: 2015-11-10
ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS
VRIJE UNIVERSITEIT ESSAYS ON MONTE CARLO METHODS FOR STATE SPACE MODELS ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk
blabla It s me Illustrations: Your Illustrator Cover design: Joke Herstel, Wenk blabla Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector
Implementations of tests on the exogeneity of selected. variables and their Performance in practice ACADEMISCH PROEFSCHRIFT
Implementations of tests on the exogeneity of selected variables and their Performance in practice ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag
ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES
ACCESS CONTROL AND SERVICE-ORIENTED ARCHITECTURES PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Tilburg, op gezag van de rector magnificus, prof.dr. F.A. van der Duyn Schouten,
Enhancing the wellbeing of older people in Mauritius
Enhancing the wellbeing of older people in Mauritius Proefschrift ter verkrijging van de graad van doctor aan Tilburg University op gezag van de rector magnificus, prof. dr. Ph. Eijlander, in het openbaar
Graphical tasks to aid in diagnosing and monitoring Parkinson s disease
Graphical tasks to aid in diagnosing and monitoring Parkinson s disease Esther J. Smits The studies described in this thesis were part of the DiPAR project for which funding was received from the EC in
Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET
Parkinson s Disease: Deep Brain Stimulation and FDOPA-PET The work described in this thesis was performed at the Department of Neurology, University Medical Center, Groningen (the Netherlands). A.T. Portman
The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case
2003 U 842 The Political Economy of Trade Liberalization in Developing Countries: The Sri Lankan Case een wetenschappelijke proeve op het gebied van de Managementwetenschappen Proefschrift ter verkrijging
SAFE BUT SORRY. Theory, assesment, and treatment of pain-related fear in chronic low back pain patients
SAFE BUT SORRY Theory, assesment, and treatment of pain-related fear in chronic low back pain patients SAFE but SORRY: Theory, assessment, and treatment of pain-related fear in chronic low back pain patients
ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS
ELECTRODYNAMICS OF SUPERCONDUCTING CABLES IN ACCELERATOR MAGNETS Publication of this thesis has been financially supported by Holec Ridderkerk, The Netherlands CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN
Authenticity and Architecture
Authenticity and Architecture Representation and Reconstruction in Context Proefschrift ter verkrijging van de graad van doctor aan Tilburg University, op gezag van de rector magnificus, prof. dr. Ph.
Cover Page. The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/33044 holds various files of this Leiden University dissertation. Author: Lamberts, Agneta Luciana Matthanja (Thanja) Title: Unraveling the surface formation
Psychosocial and medical determinants of long-term patient outcomes
Psychosocial and medical determinants of long-term patient outcomes A specific focus on patients after kidney transplantation and with haemophilia Lucia Prihodova Copyright 2014 Lucia Prihodova Copyright
EX-POST LIABILITY RULES IN MODERN PATENT LAW. Ex-post aansprakelijkheidsregels in een modern octrooirecht
EX-POST LIABILITY RULES IN MODERN PATENT LAW Ex-post aansprakelijkheidsregels in een modern octrooirecht Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag
Measuring The Costs Of Chapter 11 Cases
Measuring The Costs Of Chapter 11 Cases Professional Fees in American Corporate Bankruptcy Cases Proefschrift ter verkrijging van het doctoraat in de Rechtsgeleerdheid aan de Rijksuniversiteit Groningen
Cover Page. The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20863 holds various files of this Leiden University dissertation. Author: Maczuga, Piotr Title: Towards RNAi based therapy of liver diseases : diversity
Making the title page for your dissertation a practical guide
Making the title page for your dissertation a practical guide Contents: 1. The front the basics 2. The reverse side the basics 2.1 The reverse side Adding the (co)promotor(s) and 2.2 The reverse side Adding
Nyenrode PhD and EDP Rules and Regulations
Nyenrode PhD and EDP Rules and Regulations SECTION 1 GENERAL PROVISIONS Article 1 Legal title Article 2 Definitions SECTION 2 REGISTRATION Article 3 Registration Article 4 Fees and expenses SECTION 3 SUPERVISION
RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA
RIJKSUNIVERSITEIT GRONINGEN BOTTOM-UP REHABILITATION IN SCHIZOPHRENIA Proefschrift ter verkrijging van het doctoraat in de Geneeskunde aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus
How To Understand The Effects Of A Drug On Your Health
Farmacologia degli inibitori TK e mtor Romano Danesi Professore ordinario di Farmacologia UOC Farmacologia Universitaria Azienda Ospedaliero-Universitaria Pisana Dipartimento di Medicina Interna Università
Interaction Protocols in PARADIGM PROEFSCHRIFT
Interaction Protocols in PARADIGM Extensions to a Modeling Language through Tool Development PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus
Regulation of hepatobiliary transport function by nuclear receptors
Regulation of hepatobiliary transport function by nuclear receptors Copyright 2004 T. Kok All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without
Original Articles Research Group Personalized Medicine
Original Articles Research Group Personalized Medicine (only published papers in international peer reviewed journals during the last 5 years) 1. Binkhorst L., Bannink M., de Bruijn P., Ruit J., Droogendijk
Economics of Insurance against Climate Change. W.J. Wouter Botzen
Economics of Insurance against Climate Change W.J. Wouter Botzen Promotor: prof. dr. J.C.J.M. van den Bergh Thesis committee: prof. dr. J.C.J.H. Aerts prof. dr. H. Kunreuther prof. dr. P. Rietveld prof.
Original Articles Research Group Personalized Medicine
Original Articles Research Group Personalized Medicine (only peer reviewed journals) 1. Kloth J.S.L., Binkhorst L., de Wit A.S., de Bruijn P., Hamberg P., Lam M.H, Burger H., Chaves-Machado I., Wiemer
High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness
High Performance Human Resource Management in Ireland and the Netherlands: Adoption and Effectiveness RIJKSUNIVERSITEIT GRONINGEN High Performance Human Resource Management in Ireland and the Netherlands:
Behavioral Corporate Governance: Four Empirical Studies. Gerwin van der Laan
Behavioral Corporate Governance: Four Empirical Studies Gerwin van der Laan RIJKSUNIVERSITEIT GRONINGEN BEHAVIORAL CORPORATE GOVERNACE: Four Empirical Studies Proefschrift ter verkrijging van het doctoraat
GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE
GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE Branko Zakotnik MD, PhD Department of Medical Oncology Institute of Oncology Ljubljana 1 I have no conflict of interest to declare
Why participation works
Why participation works Full title Why participation works: the role of employee involvement in the implementation of the customer relationship management type of organizational change. Key words Participation,
Common Focus Point Technology
Common Focus Point Technology Proefschrift ter verkrijging van de graad van doctor aan de Technische Universiteit Delft, op gezag van de Rector Magnificus, Prof. dr. ir. J. Blaauwendraad in het openbaar
PhD Regulations. enacted by order of the Doctorate Board, February 14, 2014
PhD Regulations enacted by order of the Doctorate Board, February 14, 2014 3 PhD Regulations Contents I. General Provisions 5 II. The PhD candidate 6 III. The Graduate School 7 IV. The PhD thesis supervisor
Motor Learning in ACL Injury Prevention. Anne Benjaminse
Motor Learning in ACL Injury Prevention Anne Benjaminse Anne Benjaminse Motor Learning in ACL Injury Prevention Dissertation University of Groningen, the Netherlands. With summary in Dutch. Cover by: Julia
Shop floor design: layout, investments, cross-training, and labor allocation. Jos Bokhorst
Shop floor design: layout, investments, cross-training, and labor allocation Jos Bokhorst Published by: Labyrint Publications Pottenbakkerstraat 15-17 2984 AX Ridderkerk The Netherlands Tel: +31 (0) 1804-63962
De groepsleider als evenwichtskunstenaar
De groepsleider als evenwichtskunstenaar Leescommissie Prof. dr. P.H. van der Laan Prof. dr. T.V.M. Pels Prof. dr. I. Weijers Prof. dr. M. de Winter Omslagontwerp: Primo!studio Delft Foto omslag: [stockbureau
Cover Page. The handle http://hdl.handle.net/1887/22736 holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/22736 holds various files of this Leiden University dissertation. Author: Kara, Firat Title: Monitoring Alzheimer's disease in transgenic mice with ultra
Cover Page. The handle http://hdl.handle.net/1887/29589 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/29589 holds various files of this Leiden University dissertation Author: Kuruppath, Manjusha Title: Dutch drama and the company s Orient : a study of representation
Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings
RIJKSUNIVERSITEIT GRONINGEN Functional neuroinflammatoryand serotonergic imaging in Alzheimer s disease: validation and preliminary clinical findings Jan Versijpt Josef Sudek ( 1896-1976) was a famous
Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference
Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference Two New Clinical Programs and Significant Expansion of Cancer Pipeline Planned for 2004 SOUTH SAN FRANCISCO, Calif., Jan. 13 /PRNewswire-FirstCall/
Strategic Interactions in Franchise Relationships. Evelien Croonen
Strategic Interactions in Franchise Relationships Evelien Croonen Publisher: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij Ridderprint B.V.,
Background. t 1/2 of 3.7 4.7 days allows once-daily dosing (1.5 mg) with consistent serum concentration 2,3 No interaction with CYP3A4 inhibitors 4
Abstract No. 4501 Tivozanib versus sorafenib as initial targeted therapy for patients with advanced renal cell carcinoma: Results from a Phase III randomized, open-label, multicenter trial R. Motzer, D.
Caring for Oncology Patients:
: Tips and Tools for Managing Targeted Therapy Side Effects ehandbook These independent CME/CE activities are supported by educational grants from Genentech Bio Side Effects ehandbook Table of Contents
Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer
Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer Review Article [1] December 01, 2003 By George W. Sledge, Jr, MD [2] Gemcitabine (Gemzar) and paclitaxel show good activity as single
On Data Mining in Context: Cases, Fusion and Evaluation
On Data Mining in Context: Cases, Fusion and Evaluation Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens
Chronic heart failure diagnostics and application of neuropeptides. in residential elderly
Chronic heart failure diagnostics and application of neuropeptides in residential elderly Maaike Barents geboren 27 december 1950 te Utrecht Paranimfen: Els Barents Christien Enzing Barents, Maaike Chronic
Post-operative intrapleural chemotherapy for mesothelioma
Post-operative intrapleural chemotherapy for mesothelioma Robert Kratzke, MD John Skoglund Chair for Lung Cancer Research Section of Heme-Onc-Transplant University of Minnesota Medical School Efficacy
Determining the Cross-Channel Effects of Informational Web Sites. Marije L. Teerling
Determining the Cross-Channel Effects of Informational Web Sites Marije L. Teerling Published by: Labyrinth Publications Pottenbakkerstraat 15 17 2984 AX Ridderkerk The Netherlands Print: Offsetdrukkerij
Linking the Customer Purchase Process to Website Development and E-commerce Performance. Adriana C. Krawczyk
Linking the Customer Purchase Process to Website Development and E-commerce Performance Adriana C. Krawczyk Published by: SOM Research School University of Groningen PO Box 800 9700 AV Groningen The Netherlands
Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing)
Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015 (minutes for web publishing) Cancer Treatments Subcommittee minutes are published in accordance with the Terms of Reference for the
Zeroing in on Non-Small Cell Lung Cancer: Integrating Targeted Therapies into Practice
Lung Cancer: Integrating Targeted Therapies into Practice Table of Contents Program Information... 2 Faculty Biographies... 3 Genomic Profiling of NSCLC for EGFR Inhibitors... 4 Fred R. Hirsch, MD, PhD
Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022
Brochure More information from http://www.researchandmarkets.com/reports/2228475/ Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022 Description: Avastin (Renal Cell Carcinoma) Analysis and
HYDROGEN STORAGE MATERIALS A FIRST-PRINCIPLES STUDY SÜLEYMAN ER ISBN / EAN: 978-90-365-2895-5 DOI: 10.3990/1.9789036528955
ISBN / EAN: 978-90-365-2895-5 DOI: 10.3990/1.9789036528955 HYDROGEN STORAGE MATERIALS: A FIRST-PRINCIPLES STUDY SÜLEYMAN ER HYDROGEN STORAGE MATERIALS A FIRST-PRINCIPLES STUDY SÜLEYMAN ER HYDROGEN STORAGE
Towards a sustainable synthesis of aromatic isocyanates by the palladium diphosphane catalyzed reduction of nitrobenzene; a first step
Towards a sustainable synthesis of aromatic isocyanates by the palladium diphosphane catalyzed reduction of nitrobenzene; a first step PROEFSCHRIFT Ter verkrijging van de graad van Doctor aan de Universiteit
Perceived Health Status after Kidney Transplantation. Jaroslav Rosenberger
Perceived Health Status after Kidney Transplantation Jaroslav Rosenberger J. Rosenberger 2006 Oxford University Press (Chapter 3) Blackwell Publishing (Chapter 4 and 5) Lippincott Williams & Wilkins (Chapter
CHEM-E4140 Selectivity 12. Pharma Business
CHEM-E4140 Selectivity 12. Pharma Business Prof. Ari Koskinen Laboratory of Organic Chemistry C318 Pharma Business Total volume ca 1100 G$ (Shell 421G$; Walmart 486G$; Toyota 252 G$). Annually approx 25
Future Oncology: Technology, Products, Market and Service Opportunities
Brochure More information from http://www.researchandmarkets.com/reports/296370/ Future Oncology: Technology, Products, Market and Service Opportunities Description: Future Oncology is an analytical newsletter
RENSKE HOEFMAN THE IMPACT OF CAREGIVING
RENSKE HOEFMAN THE IMPACT OF CAREGIVING The Impact of Caregiving The measurement and valuation of informal care for use in economic evaluations Renske Hoefman Renske Hoefman, 2015 ISBN: 978-94-90420-56-7
Pharmacogenomic markers in EGFR-targeted therapy of lung cancer
Pharmacogenomic markers in EGFR-targeted therapy of lung cancer Rafal Dziadziuszko, MD, PhD University of Colorado Cancer Center, Aurora, CO, USA Medical University of Gdansk, Poland EMEA Workshop on Biomarkers,
A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING. Konrad Banachewicz
A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING Konrad Banachewicz VRIJE UNIVERSITEIT A COLLECTION OF PROBLEMS IN CREDIT RISK MODELING ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan
DETAINED ABROAD. Assisting Dutch nationals in foreign detention. Femke Hofstee-van der Meulen
DETAINED ABROAD Assisting Dutch nationals in foreign detention Femke Hofstee-van der Meulen Detained abroad - Assisting Dutch nationals in foreign detention Femke B.A.M. Hofstee-van der Meulen ISBN: 978-94-6295-410-6
VALUATION OF QUALITY OF LIFE IN RHEUMATOID ARTHRITIS
VALUATION OF QUALITY OF LIFE IN RHEUMATOID ARTHRITIS Laurien Buitinga Thesis, University of Twente, 2012 Laurien Buitinga ISBN: 978-90-365-3467-3 Printed by Gildeprint Drukkerijen, Enschede, The Netherlands
Design and evaluation of video portfolios. Reliability, generalizability, and validity of an authentic performance assessment for teachers
Design and evaluation of video portfolios Reliability, generalizability, and validity of an authentic performance assessment for teachers Leiden University Graduate School of Teaching This research was
PARP Inhibitors in Lung Cancer. Primo N. Lara, Jr., MD Professor of Medicine UC Davis Comprehensive Cancer Center
PARP Inhibitors in Lung Cancer Primo N. Lara, Jr., MD Professor of Medicine UC Davis Comprehensive Cancer Center Poly (ADP-ribose) Polymerase (PARP): Mechanism of Action PARPs: family of enzymes that repair
voorwerk 25-08-1999 14:03 Pagina 1
voorwerk 25-08-1999 14:03 Pagina 1 Two-handed interaction in computer supported 3D conceptual modeling voorwerk 25-08-1999 14:03 Pagina 2 ISBN 90-9013038-1 Layout: Cover: Concept: Layout and design: Computer
The EGFR mutation and precision therapy for lung cancer
for lung cancer Outcomes in advanced lung cancer have seen meaningful improvement in the past decade thanks to new precision drug therapies. Because tumors usually develop resistance to the drugs, scientists
How To Design A Network Management System
Network Management Architectures Aiko Pras CTIT Ph. D-thesis series No. 95-02 P.O. Box 217-7500 AE Enschede - The Netherlands telephone +31-53-893779 / fax +31-53-333815 Centre for Telematics and Information
How To Test For Motivation In An Instruction Manual
Motivational elements in user instructions Nicole Loorbach MOTIVATIONAL ELEMENTS IN USER INSTRUCTIONS NICOLE LOORBACH Thesis, University of Twente, 2013 Cover design by Nicole Loorbach and Nicole Nijhuis
Schedule: Drug Dose iv/infusion/oral q Doxorubicin 25mg/m 2 iv bolus Days 1, 2 & 3 Cisplatin 50mg/m 2 1L N. Saline/2hrs Days 1 & 2
Doxorubicin/Cisplatin Osteosarcoma - neoadjuvant Doxorubicin 25mg/m 2 iv bolus Days 1, 2 & 3 Cisplatin 50mg/m 2 1L N. Saline/2hrs Days 1 & 2 (3 before surgery) Ensure adequate renal function Pre & post-hydration,
BOLT Hem/Onc Thought Leader Panel #38 Cancer Immunotherapy 2014-05
Syndicated Thought Leader Insight Healthcare & Pharmaceutical Research Cancer Immunotherapy Melanoma, Non- Small Cell Lung Cancer, Renal Cell Carcinoma Thought Leader Panel #38 2014-05 Therapeutic Area:
Tasks, hierarchies, and flexibility
Tasks, hierarchies, and flexibility Planning in Food Processing Industries Wout van Wezel Uitgever: Labyrint Publication Postbus 662 2900 AR Capelle a/d IJssel Nederland Drukwerk: ISBN 90-72591-98-4 2001,
The influence of induction programs on beginning teachers well-being and professional development
The influence of induction programs on beginning teachers well-being and professional development This research was funded by the Netherlands Organization for Scientific Research (NWO). Project no. 411-02-203
What is New in Oncology. Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals
What is New in Oncology Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals Personalized Medicine Personalized Genomics Genomic Medicine Precision Medicine Definition Application
Workflow Support for the Healthcare Domain
Workflow Support for the Healthcare Domain register patient check patient data physical examination make documents consultation give information Ronny Mans Workflow Support for the Healthcare Domain CIP-DATA
Measuring and improving the quality of care from the healthcare user perspective: the Consumer Quality Index. Marloes Zuidgeest
Measuring and improving the quality of care from the healthcare user perspective: the Consumer Quality Index Marloes Zuidgeest ISBN 978 94 6122 107 0 2011 M. Zuidgeest, Bergschenhoek, the Netherlands Cover
BNC105 PHASE II RENAL CANCER TRIAL RESULTS
ABN 53 075 582 740 ASX ANNOUNCEMENT 19 March 2014 BNC105 PHASE II RENAL CANCER TRIAL RESULTS Results show BNC105 utility in patients with advanced disease Identified biomarkers which correlate with patient
Anti-angiogenesis Treatment
Anti-angiogenesis Treatment The search for better cancer drugs Today we are better able to treat cancer than ever. More than half of all people with cancer now live at least 5 years after being diagnosed.
Websites for children: Search strategies and interface design Three studies on children s search performance and evaluation. Hanna Jochmann-Mannak
Hanna Jochmann-Mannak Websites for children: Search strategies and interface design Three studies on children s search performance and evaluation Websites for children: Search strategies and interface
Scientific Spring Meeting Friday March 30, 2012
Scientific Spring Meeting Friday March 30, 2012 Dutch Society for Clinical Pharmacology and Biopharmacy Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie PROGRAMME of the SCIENTIFIC MEETING
The New Kid on the Block for Advanced Renal Cell Carcinoma
The New Kid on the Block for Advanced Renal Cell Carcinoma Wyeth Pharmaceuticals recently launched Torisel (temsirolimus), a targeted, first-in-class mtor inhibitor. This new treatment for metastatic renal
Methods for Measuring Dose Escalation in TNF Antagonists for Rheumatoid Arthritis Patients Treated in Routine Clinical Practice
Methods for Measuring Dose Escalation in TNF Antagonists for Rheumatoid Arthritis Patients Treated in Routine Clinical Practice Gu NY 1, Huang XY 2, Globe D 2, Fox KM 3 1 University of Southern California,
Effectiveness and Drug Adherence in Rheumatoid Arthritis Patients on Biologic Monotherapy: A prospective observational study in Southern Sweden
Effectiveness and Drug Adherence in Rheumatoid Arthritis Patients on Biologic Monotherapy: A prospective observational study in Southern Sweden Collaborators: Primary investigators Dr Lars Erik Kristensen,
A model applicable to other disciplines?
Conducting Phase 1 studies in Pediatric Oncology A model applicable to other disciplines? Sylvain Baruchel MD New Agent and Innovative Therapy Program Toronto Hospital For Sick Children MILESTONES IN PEDIATRIC
Instructional Design and Media Selection. Eisa H.R. Hasan. Also available in print: www.tup.utwente.nl/uk/catalogue/educational/media-selection
Instructional Design and Media Selection Eisa H.R. Hasan 2001 Ph.D. thesis University of Twente Twente University Press Also available in print: www.tup.utwente.nl/uk/catalogue/educational/media-selection
PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.
PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic
Photorefractivity in polymers
Photorefractivity in polymers George G. Malliaras Photorefractivity in Polymers George G. Malliaras Ph.D. Thesis University of Groningen, The Netherlands November 1995 ISBN 90-367-0569-x RIJKSUNIVERSITEIT
Targeted therapies and brain metastases in lung cancer patients. Benjamin Besse, MD, PhD. Medical Oncologist. 19 septembre 2014
Targeted therapies and brain metastases in lung cancer patients Benjamin Besse, MD, PhD Medical Oncologist 19 septembre 2014 Targeted therapies and brain mets! Brain mets in NSCLC! Specific targeted therapies!