Supporting Information

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1 Supporting Information Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT Chao Wang +, Daniel Abegg +, Dominic G. Hoch, and Alexander Adibekian* ange_ _sm_miscellaneous_information.pdf

2 Table of Contents Materials and General Methods... S3 Experimental Details and Procedures... S3 Supplemental Figures... S29 Supplemental Tables... S41 X-ray crystallography data... S326 Copies of 1 H NMR, 13 C NMR and HMBC Spectra... S331 References... S397 S2

3 Materials and General Methods All commercial reagents were purchased from Sigma-Aldrich or Acros of the highest purity grade. All reagents were weighed and handled in air and used without further purification, unless otherwise noted. Liquid reagents were transferred with stainless steel syringes or cannula. Thin layer chromatography (TLC) was performed on plates of silica precoated with 0.25 mm Kieselgel 60 F254. Flash chromatography was performed using silica gel µm ( mesh) from SiliCycle. 1 H NMR, 13 C NMR and HMBC NMR spectra were recorded on ARX-300, AMX-400 and AM- 500 Bruker Avance spectrometers. 1 H and 13 C{1H} NMR chemical shifts (δ) are reported in ppm relative to TMS (0.00 ppm), with the solvent resonance used as internal reference, and coupling constants (J) are in Hertz (Hz). The following abbreviations were used to explain the multiplicities: s = singlet, d = doublet, t = triplet, q = quartet, p = pentad, m = multiplet, br = broad. The mass spectrometric data were obtained at the mass spectrometry facililty of the University of Geneva. DMEM/High glucose media with GlutaMAX (with and without sodium pyruvate), RPMI-1640 with GlutaMAX, phosphate buffered saline (PBS), MEM Non-Essential Amino Acids, Penicillin Streptomycin (Pen/Strep) and Trypsin-EDTA were obtained from Life Technologies. Protein concentration was determined using the Bradford assay (Bio-Rad). All the cloning was done using the Gateway technology (Thermo Fisher Scientific). All the plasmids were prepared using the QIAprep Spin Miniprep Kit (Qiagen). For all R reactions, Q5 High-Fidelity DNA Polymerase (New England BioLabs Inc) was used as recommended by manufacturer. R cleanup was performed using the GenElute R Clean-Up following the protocol of the producer. For the BP and the LR reactions the Gateway BP Clonase Enzyme Mix and the Gateway LR Clonase Enzyme mix (Thermo Fisher Scientific) were used according to the protocol of the manufacturer. Experimental Details and Procedures Synthesis of Chloromethyl Triazole Probe 1 (AA-CW159A) To a stirred solution of tetraethylene glycol (1.94 g, mmol, 1.0 eq.) in dry CH 2Cl 2 (18 ml) cooled in an ice bath, Et 3N (4.18 ml, 30 mmol, 3.0 eq.) was added, followed by the addition of MsCl (2.32 ml, 30 mmol, 3.0 eq.). The resulting reaction mixture was stirred at 0 C for 2 h and then at r.t. for 2 h. After that, the reaction mixture was concentrated and washed with 1 M HCl (50.0 ml) and the aqueous phase was extracted with CH 2Cl 2 (10.0 ml 3). The combined organic phases were washed with sat. aq. NaHCO 3 (30.0 ml) and dried over Na 2SO 4, then filtered and concentrated in vacuo to give the crude product as a yellow oil. The product was dissolved in dry DMF (70.0 ml) and NaN 3 (2.34 g, mmol, 3.5 eq.) was added, then the reaction mixture was stirred at 60 C overnight. After the TLC showed complete consumption of the starting compound, the reaction mixture was poured into water (100.0 ml) and extracted S3

4 with EtOAc (10.0 ml 3). The combined extracts were concentrated, dried and purified by column chromatography (silica gel, 10 % 20 % EtOAc in hexane) to give the previously reported [1] product AA-CW148 (2.35 g, 96 % yield) as a colorless oil. 1 H NMR (300 MHz, CDCl 3) δ (m, 12H), 3.39 (t, J = 5.1 Hz, 4H). A screw-cap tube was charged with 1-azido-2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethane (391.0 mg, mmol, 1.6 eq.), propargyl alcohol (56.1 mg, mmol, 1.0 eq.) and dry PhMe (3.0 ml) under N 2 atmosphere. The tube was screw-capped and left for 18 h at 125 C in an oil bath under stirring. After that, the reaction mixture was concentrated in vacuo and the resulting residue was purified by column chromatography (silica gel, 2 % 6 % MeOH in EtOAc) to afford the product AA-CW155A (90.0 mg, 30 % yield) as a slightly yellow oil. 1 H NMR (400 MHz, CDCl 3) δ 7.62 (s, 1H), 4.68 (s, 2H), 4.58 (t, J = 4.8 Hz, 2H), 3.88 (t, J = 4.8 Hz, 2H), (m, 4H), (m, 6H), 3.36 (t, J = 4.9 Hz, 2H); 13 C NMR (100 MHz, CDCl 3) δ , , 70.53, 70.48, 70.44, 70.27, 70.11, 69.97, 52.57, 50.65, 48.33; HRMS (ESI) m/z Calculated for C 11H 21N 6O 4 (M+H) + : , found: Under N 2 atmosphere, to a stirred solution of (1-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)- 1H-1,2,3-triazol-5-yl)methanol (28.3 mg, mmol, 1.0 eq.) in dry CH 2Cl 2 (3.0 ml) cooled in an ice bath, Et 3N (39.3 µl, mmol, 3.0 eq.) was added, followed by the addition of MsCl (22.3 µl, mmol, 3.0 eq.). The resulting reaction mixture was stirred at 0 C for 0.5 h and then at r.t. for 0.5 h. After that, n Bu 4NCl (79.0 mg, mmol, 3.0 eq.) was added and the reaction was stirred at r.t. overnight. The reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, 2 % MeOH in CH 2Cl 2) to give the product 1 (27.7 mg, 92 % yield) as a slightly yellow oil. 1 H NMR (400 MHz, CDCl 3) δ 7.66 (s, 1H), 4.80 (s, 2H), 4.61 (t, J = 5.0 Hz, 2H), 3.90 (t, J = 5.0 Hz, 2H), (m, 4H), (m, 6H), 3.39 (t, J = 4.9 Hz, 2H); 13 C NMR (100 MHz, CDCl 3) δ , , 70.72, 70.59, 70.55, 70.49, 70.13, 70.07, 50.70, 48.74, HRMS (ESI) m/z Calculated for C 11H 20ClN 6O 3 (M+H) + : , found: S4

5 General Procedure for Synthesis of Substituted Propargylic Alcohol Compounds To a stirred solution of terminal alkyne (1.0 eq.) in dry THF (3.0 ml) under N 2 atmosphere, EtMgBr (1.2 eq., 1 M in THF) was added at r.t. and the reaction was stirred for 0.5 h. Then paraformaldehyde (1.2 eq.) was added and the resulting reaction was stirred at r.t. overnight. After that, sat. NH 4Cl (3.0 ml) was added and the organic layer was separated. The aqueous layer was extracted with EtOAc. The combined organic layers were concentrated in vacuo, dried and purified by silica gel chromatography to afford the pure product. 3-Cyclohexylprop-2-yn-1-ol was prepared from ethynylcyclohexane (487.0 mg, mmol, 1.0 eq.), EtMgBr (5.4 ml, 1 M in THF, mmol, 1.2 eq.) and paraformaldehyde (162.0 mg, mmol, 1.2 eq.). The product was purified by column chromatography (silica gel, 50 % CH 2Cl 2 in hexane, then CH 2Cl 2) as a yellow oil (582.0 mg, 94 % yield). NMR data were consistent with literature values [2] ; 1 H NMR (400 MHz, CDCl 3) δ 4.26 (s, 2H), (m, 1H), (m, 2H), (m, 2H), (m, 7H). 3-(4-(Trifluoromethoxy)phenyl)prop-2-yn-1-ol was prepared from 1-ethynyl-4- (trifluoromethoxy)benzene (560.0 mg, mmol, 1.0 eq.), EtMgBr (3.6 ml, 1 M in THF, mmol, 1.2 eq.) and paraformaldehyde (108.0 mg, mmol, 1.2 eq.). The product was purified by column chromatography (silica gel, 50 % CH 2Cl 2 in hexane, then CH 2Cl 2) as a yellow oil (645.0 mg, 99 % yield); 1 H NMR (400 MHz, CDCl 3) δ 7.45 (d, J = 8.8 Hz, 2H), 7.15 (d, J = 8.1 Hz, 2H), 4.50 (s, 2H), 1.86 (s, 1H); 13 C NMR (100 MHz, CDCl 3) δ (q, J = 1.7 Hz), , , , (q, J = Hz), 88.05, 84.31, HRMS (ESI) m/z Calculated for C 10H 8F 3O 2 (M+H) + : , found: (Pyridin-3-yl)prop-2-yn-1-ol was prepared from 3-ethynylpyridine (495.0 mg, mmol, 1.0 eq.), EtMgBr (5.8 ml, 1 M in THF, mmol, 1.2 eq.) and paraformaldehyde (174.0 mg, mmol, 1.2 eq.). The product was purified by column chromatography (silica gel, 30 % EtOAc in hexane, then EtOAc) as a white solid (456.0 mg, 71 % yield). NMR data were S5

6 consistent with literature values [3] ; 1 H NMR (400 MHz, CDCl 3) δ 8.77 (d, J = 1.5 Hz, 1H), 8.52 (dd, J = 4.9 Hz, 1.6 Hz, 1H), 7.73 (dt, J = 7.9 Hz, 1.9 Hz, 1H), 7.27 (ddd, J = 7.9 Hz, 4.8 Hz, 0.8 Hz, 1H), 4.51 (s, 2H), 3.62 (br, 1H). General Procedure for Synthesis of 1,4-substituted Hydroxymethyl Triazoles Method A: A screw-cap tube was charged with substituted propargylic alcohol (1.0 eq.), alkyl azide (1.0 eq.) and dry PhMe (2.0 ml) under N 2 atmosphere. The reaction tube was screwcapped and left overnight under stirring at 125 C in an oil bath. Note: For compounds AA-CW256A and AA-CW262A, the reaction was carried out for 3 days. Method B [4] : A screw-cap tube was charged with Cp*Ru(PPh 3) 2Cl (2.0 mol %), evacuated and filled with N 2 (3 times). Then dry PhMe (2.0 ml), substituted propargylic alcohol (1.0 eq.) and alkyl azide (1.0 eq.) were added in sequence. The reaction tube was screw-capped and left overnight under stirring at 80 C in an oil bath. The reaction vessel was then cooled to r.t. and the reaction mixture was concentrated in vacuo. The resulting residue was purified by silica gel chromatography to afford the pure 1,4- substituted hydroxymethyl triazole. The correct configuration was assigned by 2D-HMBC analysis of the correlation between the triazole ring carbons and protons on neighboring carbon atoms (see attached HMBC spectra). Methyl 2-(5-(hydroxymethyl)-4-propyl-1H-1,2,3-triazol-1-yl)acetate was prepared from hex-2- yn-1-ol (50.0 mg, mmol) and methyl 2-azidoacetate (50.2 µl, mmol) using Method A. The product (31.0 mg, 29 % yield) was purified by column chromatography (silica gel, EtOAc, then 5 % MeOH in EtOAc) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 5.23 (s, 2H), 4.67 (d, J = 5.0 Hz, 2H), 3.77 (s, 3H), 3.54 (t, J = 5.3 Hz, 1H), 2.59 (t, J = 7.6 Hz, 2H), (m, 2H), 0.91 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , 53.00, 52.52, 49.63, 26.75, 22.96, HRMS (ESI) m/z Calculated for C 9H 16N 3O 3 (M+H) + : , found: S6

7 Methyl 2-(4-cyclohexyl-5-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)acetate was prepared from 3- cyclohexylprop-2-yn-1-ol (69.1 mg, mmol) and methyl 2-azidoacetate (50.2 µl, mmol) using Method A. The product (23.0 mg, 18 % yield) was purified by column chromatography (silica gel, EtOAc, then 5 % MeOH in EtOAc) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 5.23 (s, 2H), 4.68 (d, J = 5.2 Hz, 2H), 3.78 (s, 3H), 3.39 (s, 1H), 2.65 (t, J = 12.1 Hz, 1H), (m, 4H), (m, 3H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , 53.03, 52.52, 49.56, 35.07, 32.88, 26.53, HRMS (ESI) m/z Calculated for C 12H 20N 3O 3 (M+H) + : , found: Methyl 2-(5-(hydroxymethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)acetate was prepared from 3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol (108.0 mg, mmol) and methyl 2-azidoacetate (50.2 µl, mmol) using Method A. The product (50.0 mg, 30 % yield) was purified by column chromatography (silica gel, 40 % EtOAc in hexane) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 7.77 (d, J = 8.8 Hz, 2H), 7.30 (d, J = 9.0 Hz, 2H), 5.31 (s, 2H), 4.80 (d, J = 5.4 Hz, 2H), 3.84 (s, 3H), 3.59 (t, J = 5.7 Hz, 1H). 13 C NMR (100 MHz, CDCl 3) δ , (q, J = 2.0 Hz), , , , , , (q, J = Hz), 53.31, 52.80, HRMS (ESI) m/z Calculated for C 13H 13F 3N 3O 4 (M+H) + : , found: Methyl 2-(5-(hydroxymethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl)acetate was prepared form 3-(naphthalen-1-yl)prop-2-yn-1-ol (94.9 mg, mmol) and methyl 2-azidoacetate (50.2 µl, mmol) using Method A. The product (17.0 mg, 11 % yield) was purified by column chromatography (silica gel, 50 % EtOAc in hexane) as a slightly brown solid; 1 H NMR (400 MHz, CDCl 3) δ (m, 3H), (m, 4H), 5.41 (s, 2H), 4.69 (s, 2H), 3.87 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , , 53.38, 53.22, HRMS (ESI) m/z Calculated for C 16H 16N 3O 3 (M+H) + : , found: S7

8 Methyl 2-(5-(hydroxymethyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)acetate was prepared from 3-(pyridin-3-yl)prop-2-yn-1-ol (33.3 mg, mmol) and methyl 2-azidoacetate (25.1 µl, mmol) using Method A. The product (35.0 mg, 56 % yield) was purified by column chromatography (silica gel, 2 % MeOH in EtOAc) as a yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 8.68 (s, 1H), 8.44 (d, J = 4.0 Hz, 1H), 8.02 (d, J = 7.9 Hz, 1H), 7.33 (dd, J = 7.7, 4.9 Hz, 1H), 5.36 (s, 2H), 4.81 (s, 2H), 3.80 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , 53.18, 52.55, HRMS (ESI) m/z Calculated for C 11H 13N 4O 3 (M+H) + : , found: (1-(2-Morpholinoethyl)-4-propyl-1H-1,2,3-triazol-5-yl)methanol was prepared from hex-2-yn-1- ol (25.3 mg, mmol) and 4-(2-azidoethyl)morpholine (39.0 mg, mmol) using Method B. The product (14.0 mg, 22 % yield) was purified by column chromatography (silica gel, 4 % 5 % MeOH in CH 2Cl 2) as a yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 4.55 (s, 2H), (m, 2H), 3.69 (t, J = 4.7 Hz, 4H), (m, 2H), 2.68 (t, J = 7.6 Hz, 2H), 2.48 (t, J = 4.6 Hz, 4H), (m, 2H), 0.95 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , 65.95, 59.37, 54.32, 50.99, 45.87, 26.95, 23.22, HRMS (ESI) m/z Calculated for C 12H 23N 4O 2 (M+H) + : , found: (4-Cyclohexyl-1-(2-morpholinoethyl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3- cyclohexylprop-2-yn-1-ol (34.6 mg, mmol) and 4-(2-azidoethyl)morpholine (39.0 mg, mmol) using Method B. The product (27.0 mg, 37 % yield) was purified by column chromatography (silica gel, EtOAc, then 5 % MeOH in EtOAc) as a yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 4.78 (s, 2H), 4.34 (t, J = 6.8 Hz, 2H), 3.67 (t, J = 4.6 Hz, 4H), 2.81 (t, J = 6.8 Hz, 2H), 2.71 (tt, J = 12.2, 3.3 Hz, 1H), 2.49 (t, J = 4.6 Hz, 4H), (m, 5H), (m, 2H), (m, 4H); 13 C NMR (100 MHz, CDCl 3) δ , , 66.81, 58.57, 56.71, 53.86, 45.56, 34.79, 31.89, 26.65, HRMS (ESI) m/z Calculated for C 15H 27N 4O 2 (M+H) + : , found: S8

9 (1-(2-Morpholinoethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol (54.0 mg, mmol) and 4-(2- azidoethyl)morpholine (39.0 mg, mmol) using Method B. The product (38.0 mg, 41 % yield) was purified by column chromatography (silica gel, 2 % 3 % MeOH in CH 2Cl 2) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 7.81 (d, J = 8.6 Hz, 2H), 7.30 (d, J = 8.3 Hz, 2H), 4.64 (s, 2H), (m, 2H), 3.73 (t, J = 4.5 Hz, 4H), (m, 2H), 2.54 (t, J = 4.3 Hz, 4H); 13 C NMR (100 MHz, CDCl 3) δ (q, J = 1.7 Hz), , , , , , (q, J = Hz), 65.93, 59.54, 54.30, 51.34, HRMS (ESI) m/z Calculated for C 16H 20F 3N 4O 3 (M+H) + : , found: (1-(2-Morpholinoethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3-(naphthalen-1-yl)prop-2-yn-1-ol (45.5 mg, mmol) and 4-(2-azidoethyl)morpholine (39.0 mg, mmol) using Method B. The product (16.0 mg, 19 % yield) was purified by column chromatography (silica gel, 2 % 3 % MeOH in EtOAc) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ (m, 1H), (m, 2H), 7.64 (dd, J = 7.0 Hz, 1.0 Hz, 1H), (m, 3H), (m, 2H), 4.56 (s, 2H), 3.77 (t, J = 4.6 Hz, 4H), (m, 2H), 2.58 (t, J = 4.5 Hz, 4H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , 66.00, 59.41, 54.40, 51.47, HRMS (ESI) m/z Calculated for C 19H 23N 4O 2 (M+H) + : , found: (1-(4-Bromobenzyl)-4-propyl-1H-1,2,3-triazol-5-yl)methanol was prepared from hex-2-yn-1-ol (50.6 mg, mmol) and 1-(azidomethyl)-4-bromobenzene (1.0 ml, ~ 0.5 M in CH 2Cl 2, 0.5 mmol) using Method A. The product (32.0 mg, 21 % yield) was purified by column chromatography (silica gel, 50 % EtOAc in hexane) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 7.45 (d, J = 8.4 Hz, 2H), 7.11 (d, J = 8.4 Hz, 2H), 5.55 (s, 2H), 4.54 (d, J = 4.5 Hz, 2H), 2.68 (t, J = 4.6 Hz, 1H), 2.57 (t, J = 7.6 Hz, 2H), (m, 2H), 0.90 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , 52.32, 51.70, 26.79, 23.12, HRMS (ESI) m/z Calculated for C 13H 17BrN 3O (M+H) + : , found: S9

10 (1-(4-Bromobenzyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3- (pyridin-3-yl)prop-2-yn-1-ol (33.3 mg, mmol) and 1-(azidomethyl)-4-bromobenzene (0.5 ml, ~ 0.5 M in CH 2Cl 2, mmol) using Method B. The product (30.0 mg, 35 % yield) was purified by column chromatography (silica gel, EtOAc, then 3 % MeOH in EtOAc) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 8.71 (br, 1H), 8.47 (br, 1H), 8.08 (d, J = 7.8 Hz, 1H), 7.50 (d, J = 8.4 Hz, 2H), 7.38 (br, 1H), 7.23 (d, J = 8.4 Hz, 2H), 5.69 (s, 2H), 4.72 (s, 2H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , 52.27, HRMS (ESI) m/z Calculated for C 15H 14BrN 4O (M+H) + : , found: (Benzo[d][1,3]dioxol-5-yl)-2-(5-(hydroxymethyl)-4-propyl-1H-1,2,3-triazol-1-yl)ethan-1-one was prepared from hex-2-yn-1-ol (15.2 mg, mmol) and 2-azido-1-(benzo[d][1,3]dioxol-5- yl)ethan-1-one (31.0 mg, mmol) using Method B. The product (17.0 mg, 37 % yield) was purified by column chromatography (silica gel, EtOAc, then 2 % MeOH in EtOAc) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ 7.62 (dd, J = 8.2 Hz, 1.6 Hz, 1H), 7.43 (d, J = 1.5 Hz, 1H), 6.91 (d, J = 8.2 Hz, 1H), 6.09 (s, 2H), 5.82 (s, 2H), 4.62 (s, 2H), 2.66 (t, J = 7.6 Hz, 2H), (m, 2H), 0.95 (t, J = 7.3 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 54.18, 52.72, 26.89, 23.03, HRMS (ESI) m/z Calculated for C 15H 18N 3O 4 (M+H) + : , found: (Benzo[d][1,3]dioxol-5-yl)-2-(4-cyclohexyl-5-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)ethan-1- one was prepared from 3-cyclohexylprop-2-yn-1-ol (16.6 mg, mmol) and 2-azido-1- (benzo[d][1,3]dioxol-5-yl)ethan-1-one (25.0 mg, mmol) using Method A. The product (11.0 mg, 27 % yield) was purified by column chromatography (silica gel, 50 % EtOAc in hexane) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ 7.56 (dd, J = 8.2 Hz, 1.5 Hz, 1H), 7.37 (d, J = 1.4 Hz, 1H), 6.84 (d, J = 8.2 Hz, 1H), 6.02 (s, 2H), 5.74 (s, 2H), 4.56 (s, 2H), 2.64 (t, J = 11.9 Hz, 1H), (m, 4H), (m, 3H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 54.04, 52.73, 35.21, 32.93, 26.58, HRMS (ESI) m/z Calculated for C 18H 22N 3O 4 (M+H) + : , found: S10

11 1-(Benzo[d][1,3]dioxol-5-yl)-2-(5-(hydroxymethyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)ethan- 1-one was prepared from 3-(pyridin-3-yl)prop-2-yn-1-ol (16.0 mg, mmol) and 2-azido-1- (benzo[d][1,3]dioxol-5-yl)ethan-1-one (25.0 mg, mmol) using Method A. The product (17.0 mg, 42 % yield) was purified by column chromatography (silica gel, 2 % 3 % MeOH in EtOAc) as a white solid; 1 H NMR (400 MHz, MeOD) δ 9.09 (br, 1H), 8.71 (br, 1H), 8.47 (d, J = 8.0 Hz, 1H), 7.83 (dd, J = 8.2, 1.5 Hz, 1H), 7.78 (br, 1H), 7.56 (d, J = 1.4 Hz, 1H), 7.04 (d, J = 8.2 Hz, 1H), 6.19 (s, 2H), 6.14 (s, 2H), 4.79 (s, 2H); 13 C NMR (100 MHz, MeOD) δ , , , , , , , , , , , , , 54.49, HRMS (ESI) m/z Calculated for C 17H 15N 4O 4 (M+H) + : , found: (1-(2-(3,5-Dimethylisoxazol-4-yl)ethyl)-4-propyl-1H-1,2,3-triazol-5-yl)methanol was prepared from hex-2-yn-1-ol (24.5 mg, mmol) and 4-(2-azidoethyl)-3,5-dimethylisoxazole (41.6 mg, mmol) using Method B. The product (19.0 mg, 29 % yield) was purified by column chromatography (silica gel, EtOAc) as a brown oil; 1 H NMR (400 MHz, CDCl 3) δ (m, 4H), 2.97 (t, J = 7.0 Hz, 2H), 2.57 (t, J = 7.6 Hz, 2H), 2.13 (s, 3H), 2.10 (s, 3H), (m, 2H), 0.92 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , 52.31, 47.77, 26.80, 23.55, 23.33, 13.75, 10.52, HRMS (ESI) m/z Calculated for C 13H 21N 4O 2 (M+H) + : , found: (4-Cyclohexyl-1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3-cyclohexylprop-2-yn-1-ol (34.6 mg, mmol) and 4-(2-azidoethyl)-3,5- dimethylisoxazole (41.6 mg, mmol) using Method B. The product (43.0 mg, 56 % yield) was purified by column chromatography (silica gel, EtOAc) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ 4.74 (s, 2H), 4.29 (t, J = 6.8 Hz, 2H), 3.13 (br, 1H), 2.89 (t, J = 6.8 Hz, 2H), (m, 1H), 2.13 (s, 3H), 2.03 (s, 3H), (m, 2H), (m, 1H), (m, 4H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , 56.36, 47.08, 35.10, 31.67, 26.69, 25.48, 23.78, 10.42, HRMS (ESI) m/z Calculated for C 16H 25N 4O 2 (M+H) + : , found: S11

12 (1-(2-(3,5-Dimethylisoxazol-4-yl)ethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-5- yl)methanol was prepared from 3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol (130.0 mg, mmol) and 4-(2-azidoethyl)-3,5-dimethylisoxazole (100.0 mg, mmol) using Method B. The product (140.0 mg, 61 % yield) was purified by column chromatography (silica gel, 50 % EtOAc in hexane) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ 7.59 (d, J = 8.2 Hz, 2H), 7.20 (d, J = 8.2 Hz, 2H), 4.68 (br, 1H), 4.61 (s, 2H), 4.46 (t, J = 6.9 Hz, 2H), 2.94 (t, J = 6.9 Hz, 2H), 2.06 (s, 3H), 2.05 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , (q, J = 1.7 Hz), , , , , , (q, J = Hz), , 52.13, 47.99, 23.38, 10.42, HRMS (ESI) m/z Calculated for C 17H 18F 3N 4O 3 (M+H) + : , found: (1-(2-(3,5-Dimethylisoxazol-4-yl)ethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-5-yl)methanol was prepared from 3-(naphthalen-1-yl)prop-2-yn-1-ol (45.5 mg, mmol) and 4-(2-azidoethyl)- 3,5-dimethylisoxazole (41.6 mg, mmol) using Method B. The product (12.0 mg, 14 % yield) was purified by column chromatography (silica gel, 30 % 60 % EtOAc in hexane) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ 7.92 (t, J = 7.7 Hz, 2H), 7.86 (d, J = 7.8 Hz, 1H), (m, 3H), 7.42 (dd, J = 7.0 Hz, 0.9 Hz, 1H), 4.63 (t, J = 7.0 Hz, 2H), 4.47 (s, 2H), 3.12 (t, J = 7.0 Hz, 2H), 2.23 (s, 3H), 2.22 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , , , , 52.84, 48.16, 23.63, 10.64, HRMS (ESI) m/z Calculated for C 20H 21N 4O 2 (M+H) + : , found: General Procedure for Synthesis of 1,4-substituted Chloromethyl Triazoles To a solution of 1,4-substituted hydroxymethyl triazole (1.0 eq.) in dry CH 2Cl 2 (1.0 ml) cooled in an ice bath, Et 3N (1.5 eq.) was added, followed by the addition of MsCl (1.5 eq.). The reaction was stirred at 0 C for 0.5 h and then at r.t. for 0.5 h. After that, n Bu 4NCl (1.5 eq.) was added and the reaction was stirred at r.t. for 1 h. The reaction mixture was concentrated in vacuo and the resulting residue was purified with silica gel chromatography to afford the pure 1,4- substituted chloromethyl triazole. S12

13 Methyl 2-(5-(chloromethyl)-4-propyl-1H-1,2,3-triazol-1-yl)acetate (12) was prepared from methyl 2-(5-(hydroxymethyl)-4-propyl-1H-1,2,3-triazol-1-yl)acetate (12.0 mg, mmol). The product (12.6 mg, 97 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a colorless oil; 1 H NMR (400 MHz, CDCl 3) δ 5.24 (s, 2H), 4.61 (d, J = 5.0 Hz, 2H), 3.81 (s, 3H), 2.67 (t, J = 7.5 Hz, 2H), (m, 2H), 0.97 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , 53.10, 49.46, 31.98, 26.92, 22.74, HRMS (ESI) m/z Calculated for C 9H 15ClN 3O 2 (M+H) + : , found: Methyl 2-(5-(chloromethyl)-4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetate (11) was prepared from methyl 2-(4-cyclohexyl-5-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)acetate (10.5 mg, mmol). The product (11.1 mg, 98 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a colorless oil; 1 H NMR (400 MHz, CDCl 3) δ 5.23 (s, 2H), 4.63 (d, J = 5.0 Hz, 2H), 3.81 (s, 3H), 2.67 (tt, J = 12.0 Hz, 3.4 Hz, 1H), (m, 4H), (m, 2H), (m, 4H); 13 C NMR (100 MHz, CDCl 3) δ , , , 53.08, 49.36, 35.23, 32.62, 32.04, 26.47, HRMS (ESI) m/z Calculated for C 12H 19ClN 3O 2 (M+H) + : , found: Methyl 2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)acetate (14) was prepared from methyl 2-(5-(hydroxymethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)acetate (13.8 mg, mmol). The product (12.9 mg, 88 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 7.77 (d, J = 8.7 Hz, 2H), 7.37 (d, J = 8.2 Hz, 2H), 5.34 (s, 2H), 4.76 (s, 2H), 3.86 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , (q, J = 2.0 Hz), , , , , , (q, J = Hz), 53.30, 49.53, HRMS (ESI) m/z Calculated for C 13H 12ClF 3N 3O 3 (M+H) + : , found: S13

14 Methyl 2-(5-(chloromethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl)acetate (13) was prepared from methyl 2-(5-(hydroxymethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl)acetate (11.3 mg, mmol). The product (11.9 mg, 99 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a brown solid; 1 H NMR (400 MHz, CDCl 3) δ (m, 3H), (m, 2H), (m, 2H), 5.45 (s, 2H), 4.63 (s, 2H), 3.89 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , , 53.26, 49.84, HRMS (ESI) m/z Calculated for C 16H 15ClN 3O 2 (M+H) + : , found: Methyl 2-(5-(chloromethyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)acetate (10) was prepared from methyl 2-(5-(hydroxymethyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)acetate (9.2 mg, mmol). The product (9.8 mg, 99 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 8.95 (br, 1H), 8.69 (d, J = 4.2 Hz, 1H), 8.09 (d, J = 7.9 Hz, 1H), 7.45 (dd, J = 7.8 Hz, 4.8 Hz, 1H), 5.35 (s, 2H), 4.77 (s, 2H), 3.86 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , 53.35, 49.59, HRMS (ESI) m/z Calculated for C 11H 12ClN 4O 2 (M+H) + : , found: (2-(5-(Chloromethyl)-4-propyl-1H-1,2,3-triazol-1-yl)ethyl)morpholine (8) was prepared from (1-(2-morpholinoethyl)-4-propyl-1H-1,2,3-triazol-5-yl)methanol (7.1 mg, mmol). The product (6.5 mg, 85 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then 5 % MeOH in EtOAc) as a colorless oil; 1 H NMR (400 MHz, CDCl 3) δ 4.73 (s, 2H), 4.49 (br, 2H), 3.70 (br, 4H), 2.91 (br, 2H), 2.67 (t, J = 7.6 Hz, 2H), 2.53 (br, 4H), (m, 2H), 0.97 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , 66.77, 58.23, 53.82, 46.07, 32.13, 26.98, 22.81, HRMS (ESI) m/z Calculated for C 12H 22ClN 4O (M+H) + : , found: S14

15 4-(2-(5-(Chloromethyl)-4-cyclohexyl-1H-1,2,3-triazol-1-yl)ethyl)morpholine (9) was prepared from (4-cyclohexyl-1-(2-morpholinoethyl)-1H-1,2,3-triazol-5-yl)methanol (13.6 mg, mmol). The product (8.9 mg, 62 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then 5 % MeOH in EtOAc) as a colorless oil; 1 H NMR (400 MHz, CDCl 3) δ 4.78 (s, 2H), 4.36 (t, J = 6.7 Hz, 2H), 3.69 (t, J = 4.5 Hz, 4H), 2.85 (t, J = 6.7 Hz, 2H), 2.77 (tt, J = 12.2 Hz, 3.2 Hz, 1H), 2.52 (t, J = 4.3 Hz, 4H), (m, 4H), (m, 3H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , 66.80, 58.46, 53.88, 45.69, 37.35, 34.96, 31.51, 26.63, HRMS (ESI) m/z Calculated for C 15H 26ClN 4O (M+H) + : , found: (2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)morpholine (15) was prepared from (1-(2-morpholinoethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol- 5-yl)methanol (26.7 mg, mmol). The product (17.9 mg, 64 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a yellow oil; 1 H NMR (400 MHz, CDCl 3) δ 7.78 (d, J = 8.8 Hz, 2H), 7.36 (d, J = 8.0 Hz, 2H), 4.89 (s, 2H), 4.57 (t, J = 6.2 Hz, 2H), 3.69 (t, J = 4.5 Hz, 4H), 2.97 (t, J = 6.1 Hz, 2H), 2.56 (t, J = 4.3 Hz, 4H); 13 C NMR (100 MHz, CDCl 3) δ (q, J = 1.7 Hz), , , , , , (q, J = Hz), 66.82, 58.26, 53.85, 46.36, HRMS (ESI) m/z Calculated for C 16H 19ClF 3N 4O 2 (M+H) + : , found: (2-(5-(Chloromethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl)ethyl)morpholine (2) was prepared from (1-(2-morpholinoethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-5-yl)methanol (10.8 mg, mmol). The product (9.3 mg, 82 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a yellow solid; 1 H NMR (300 MHz, CDCl 3) δ (m, 3H), (m, 4H), 4.75 (s, 2H), 4.69 (t, J = 6.3 Hz, 2H), 3.73 (t, J = 4.5 Hz, 4H), 3.08 (t, J = 6.2 Hz, 2H), 2.63(t, J = 4.3 Hz, 4H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , 66.81, 58.31, 53.92, 46.47, HRMS (ESI) m/z Calculated for C 19H 22ClN 4O (M+H) + : , found: S15

16 1-(4-Bromobenzyl)-5-(chloromethyl)-4-propyl-1H-1,2,3-triazole (3) was prepared from (1-(4- bromobenzyl)-4-propyl-1h-1,2,3-triazol-5-yl)methanol (9.3 mg, mmol). The product (7.9 mg, 80 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 7.50 (d, J = 8.4 Hz, 2H), 7.13 (d, J = 8.4 Hz, 2H), 5.58 (s, 2H), 4.38 (s, 2H), 2.65 (t, J = 7.5 Hz, 2H), (m, 2H), 0.96 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , 51.84, 31.78, 26.91, 22.76, HRMS (ESI) m/z Calculated for C 13H 16BrClN 3 (M+H) + : , found: (1-(4-Bromobenzyl)-5-(chloromethyl)-1H-1,2,3-triazol-4-yl)pyridine (4) was prepared from (1-(4-bromobenzyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-5-yl)methanol (9.4 mg, mmol). The product (9.2 mg, 93 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 8.94 (br, 1H), 8.68 (d, J = 4.1 Hz, 1H), 8.09 (d, J = 7.9 Hz, 1H), 7.53 (d, J = 8.3 Hz, 2H), 7.45 (dd, J = 7.8 Hz, 4.8 Hz, 1H), 7.21 (d, J = 8.3 Hz, 2H), 5.68 (s, 2H), 4.56 (s, 2H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , 52.13, HRMS (ESI) m/z Calculated for C 15H 13BrClN 4 (M+H) + : , found: (Benzo[d][1,3]dioxol-5-yl)-2-(5-(chloromethyl)-4-propyl-1H-1,2,3-triazol-1-yl)ethan-1-one (5) was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-2-(5-(hydroxymethyl)-4-propyl-1H-1,2,3- triazol-1-yl)ethan-1-one (5.4 mg, mmol). The product (5.0 mg, 87 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as an orange solid; 1 H NMR (400 MHz, CDCl 3) δ 7.65 (dd, J = 8.2 Hz, 1.6 Hz, 1H), 7.47 (d, J = 1.5 Hz, 1H), 6.95 (d, J = 8.2 Hz, 1H), 6.11 (s, 2H), 5.87 (s, 2H), 4.59 (s, 2H), 2.72 (t, J = 7.5 Hz, 2H), (m, 2H), 1.00 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 54.27, 32.47, 27.00, 22.80, HRMS (ESI) m/z Calculated for C 15H 17ClN 3O 3 (M+H) + : , found: S16

17 1-(Benzo[d][1,3]dioxol-5-yl)-2-(5-(chloromethyl)-4-cyclohexyl-1H-1,2,3-triazol-1-yl)ethan-1- one (6) was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-2-(4-cyclohexyl-5-(hydroxymethyl)-1H- 1,2,3-triazol-1-yl)ethan-1-one (8.2 mg, mmol). The product (7.4 mg, 86 % yield) was purified by column chromatography (silica gel, 50 % EtOAc in hexane) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 7.65 (dd, J = 8.2 Hz, 1.4 Hz, 1H), 7.46 (d, J = 1.4 Hz, 1H), 6.94 (d, J = 8.2 Hz, 1H), 6.11 (s, 2H), 5.85 (s, 2H), 4.61 (s, 2H), 2.71 (t, J = 11.9 Hz, 1H), (m, 4H), (m, 3H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 54.16, 35.28, 32.67, 32.53, 26.52, HRMS (ESI) m/z Calculated for C 18H 21ClN 3O 3 (M+H) + : , found: (Benzo[d][1,3]dioxol-5-yl)-2-(5-(chloromethyl)-4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl)ethan-1- one (7) was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-2-(5-(hydroxymethyl)-4-(pyridin-3-yl)- 1H-1,2,3-triazol-1-yl)ethan-1-one (7.1 mg, mmol). The product (4.6 mg, 61 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a white solid; 1 H NMR (400 MHz, CDCl 3) δ 9.05 (br, 1H), 8.77 (br, 1H), 8.15 (d, J = 7.7 Hz, 1H), 7.69 (d, J = 7.5 Hz, 1H), (m, 2H), 6.98 (d, J = 8.1 Hz, 1H), 6.13 (s, 2H), 5.97 (s, 2H), 4.74 (s, 2H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , , , , 54.36, HRMS (ESI) m/z Calculated for C 17H 14ClN 4O 3 (M+H) + : , found: (2-(5-(Chloromethyl)-4-propyl-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole (18) was prepared from (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-propyl-1H-1,2,3-triazol-5-yl)methanol (15.5 mg, mmol). The product (13.3 mg, 80 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a yellow oil; 1 H NMR (400 MHz, CDCl 3) δ 4.39 (t, J = 7.0 Hz, 2H), 4.34 (s, 2H), 3.01 (t, J = 7.0 Hz, 2H), 2.64 (t, J = 7.5 Hz, 2H), 2.17 (s, 3H), 2.13 (s, 3H), (m, 2H), 0.96 (t, J = 7.4 Hz, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , 47.80, 31.55, 26.88, 23.42, 22.90, 13.75, 10.59, HRMS (ESI) m/z Calculated for C 13H 20ClN 4O (M+H) + : , found: S17

18 4-(2-(5-(Chloromethyl)-4-cyclohexyl-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole (17) was prepared from (4-cyclohexyl-1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-1H-1,2,3-triazol-5- yl)methanol (14.7 mg, mmol). The product (15.4 mg, 99 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly yellow oil; 1 H NMR (400 MHz, CDCl 3) δ 4.74 (s, 2H), 4.31 (t, J = 6.7 Hz, 2H), 2.93 (t, J = 6.7 Hz, 2H), (m, 1H), 2.15 (s, 3H), 2.03 (s, 3H), (m, 2H), (m, 1H), (m, 4H), (m, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , 47.17, 37.07, 35.25, 31.35, 26.66, 25.50, 23.78, 10.38, HRMS (ESI) m/z Calculated for C 16H 24ClN 4O (M+H) + : , found: (2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5- dimethylisoxazole (19) was prepared from (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-(4- (trifluoromethoxy)phenyl)-1h-1,2,3-triazol-5-yl)methanol (13.5 mg, mmol). The product (13.0 mg, 92 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly yellow solid; 1 H NMR (400 MHz, CDCl 3) δ 7.73 (d, J = 8.7 Hz, 2H), 7.36 (d, J = 8.2 Hz, 2H), 4.51 (s, 2H), 4.48 (t, J = 7.1 Hz, 2H), 3.10 (t, J = 7.1 Hz, 2H), 2.22 (s, 3H), 2.18 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , (q, J = 1.7 Hz), , , , , (q, J = Hz), , 48.00, 32.20, 23.42, 10.68, HRMS (ESI) m/z Calculated for C 17H 17ClF 3N 4O 2 (M+H) + : , found: (2-(5-(Chloromethyl)-4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole (16) was prepared from (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-(naphthalen-1-yl)-1H-1,2,3- triazol-5-yl)methanol (8.3 mg, mmol). The product (8.2 mg, 94 % yield) was purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) as a slightly brown solid; 1 H NMR (400 MHz, CDCl 3) δ (m, 3H), (m, 4H), 4.59 (t, J = 7.1 Hz, 2H), 4.34 (s, 2H), 3.17 (t, J = 7.1 Hz, 2H), 2.26 (s, 3H), 2.25 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , , , , , 48.25, 32.36, 23.49, 10.76, HRMS (ESI) m/z Calculated for C 20H 20ClN 4O (M+H) + : , found: S18

19 Synthesis of AA-CW236 Derivatives Under N 2 atmosphere, to a stirred solution of 4-methoxyiodobenzene (702.0 mg, mmol, 1.0 eq.), Pd(PPh 3) 2Cl 2 (21.1 mg, 0.03 mmol, 1.0 mol %) and CuI (11.4 mg, mmol, 2.0 mol %) in Et 3N/CH 3CN (1:1, 4.0 ml) as well as propargyl alcohol (210 µl, mmol, 1.2 eq.) were added and the resulting reaction was stirred at r.t. After stirring for 3 h, the reaction mixture was poured into water and extracted with CH 2Cl 2, then the combined organic phases were concentrated in vacuo and purified by column chromatography (silica gel, CH 2Cl 2) to afford the previously reported [5] product AA-CW659 (483.0 mg, 99 % yield) as a slightly yellow solid. 1 H NMR (400 MHz, CDCl 3) δ 7.37 (d, J = 8.8 Hz, 2H), 6.83 (d, J = 8.8 Hz, 2H), 4.48 (s, 2H), 3.80 (s, 3H). A screw-cap tube was charged with Cp*Ru(PPh 3) 2Cl (8.0 mg, mmol, 2.0 mol %), evacuated and filled with N 2 (3 times). Then, dry PhMe (2.0 ml), 3-(4-methoxyphenyl)prop-2- yn-1-ol (81.1 mg, mmol, 1.0 eq.) and 4-(2-azidoethyl)-3,5-dimethylisoxazole (83.1 mg, mmol, 1.0 eq.) were added in sequence. The reaction tube was screw-capped and left overnight under stirring at 80 C in an oil bath. After that, the reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, 80 % - 90 % EtOAc in hexane) to give the product AA-CW661A (97.4 mg, 59 % yield) as a slightly brown solid. 1 H NMR (400 MHz, CDCl 3) δ 7.45 (d, J = 8.7 Hz, 2H), 6.88 (d, J = 8.7 Hz, 2H), 4.58 (s, 2H), 4.42 (t, J = 7.1 Hz, 2H), 3.78 (s, 3H), 2.91 (t, J = 7.1 Hz, 2H), 2.07 (s, 3H), 2.06 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , 55.31, 52.35, 47.93, 23.45, 10.50, HRMS (ESI) m/z Calculated for C 17H 21N 4O 3 (M+H) + : , found: To a stirred solution of (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-(4-methoxyphenyl)-1H-1,2,3- triazol-5-yl)methanol (39.4 mg, mmol, 1.0 eq.) in dry CH 2Cl 2 (2.0 ml) cooled in an ice bath, Et 3N (25.1 µl, mmol, 1.5 eq.) was added, followed by the addition of MsCl (14.2 µl, mmol, 1.5 eq.). The reaction was stirred at 0 C for 0.5 h and then at r.t. for 0.5 h. After S19

20 that, n Bu 4NCl (50.0 mg, mmol, 1.5 eq.) was added and the reaction was stirred at r.t. for 1 h. The reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) to give the product AA-CW236-2 (41.3 mg, 99 % yield) as a white solid. 1 H NMR (400 MHz, CDCl 3) δ 7.58 (d, J = 8.7 Hz, 2H), 6.99 (d, J = 8.7 Hz, 2H), 4.49 (s, 2H), 4.42 (t, J = 7.1 Hz, 2H), 3.83 (s, 3H), 3.04 (t, J = 7.1 Hz, 2H), 2.18 (s, 3H), 2.14 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , 55.37, 47.88, 32.67, 23.40, 10.65, HRMS (ESI) m/z Calculated for C 17H 20ClN 4O 2 (M+H) + : , found: A screw-cap tube was charged with Cp*Ru(PPh 3) 2Cl (8.0 mg, mmol, 2.0 mol %), evacuated and filled with N 2 (3 times). Then, dry PhMe (2.0 ml), 3-phenylprop-2-yn-1-ol (66.1 mg, mmol, 1.0 eq.) and 4-(2-azidoethyl)-3,5-dimethylisoxazole (83.1 mg, mmol, 1.0 eq.) were added in sequence. The reaction tube was screw-capped and left overnight under stirring at 80 C in an oil bath. After that, the reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, 60 % 70 % EtOAc in hexane) to give the product AA-CW666A (59.3 mg, 40 % yield) as a white solid. 1 H NMR (400 MHz, DMSO-d 6) δ 7.71 (d, J = 7.9 Hz, 2H), 7.49 (t, J = 7.5 Hz, 2H), 7.40 (t, J = 7.4 Hz, 1H), 5.69 (t, J = 5.0 Hz, 1H), 4.59 (d, J = 4.9 Hz, 2H), 4.54 (t, J = 6.8 Hz, 2H), 2.95 (t, J = 6.8 Hz, 2H), 2.09 (s, 6H); 13 C NMR (100 MHz, DMSO-d 6) δ , , , , , , , , , 51.45, 47.89, 23.15, 10.52, HRMS (ESI) m/z Calculated for C 16H 19N 4O 2 (M+H) + : , found: To a stirred solution of 1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-phenyl-1H-1,2,3-triazol-5- yl)methanol (12.4 mg, mmol, 1.0 eq.) in dry CH 2Cl 2 (2.0 ml) cooled in an ice bath, Et 3N (8.7 µl, mmol, 1.5 eq.) was added, followed by the addition of MsCl (4.9 µl, mmol, 1.5 eq.). The reaction was stirred at 0 C for 0.5 h and then at r.t. for 0.5 h. After that, n Bu 4NCl (17.3 mg, mmol, 1.5 eq.) was added and the reaction was stirred at r.t. for 1 h. The reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) to give the product AA-CW236-3 (12.2 mg, 93 % yield) as a white solid. 1 H NMR (400 MHz, CDCl 3) δ 7.68 (d, J = 7.1 Hz, 2H), 7.49 (t, J = 7.4 Hz, 2H), 7.43 (t, J = 7.3 Hz, 1H), 4.51 (s, 2H), 4.47 (t, J = 7.1 Hz, 2H), 3.08 (t, J = 7.1 Hz, 2H), 2.21 (s, 3H), 2.17 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , 47.94, 32.48, 23.46, 10.67, HRMS (ESI) m/z Calculated for C 16H 18ClN 4O (M+H) + : , found: S20

21 Synthesis of the Clickable Probe 20 (AA-CW538) Under N 2 atmosphere, to a stirred solution of 4-iodophenol (825.0 mg, mmol, 1.0 eq.), Pd(PPh 3) 2Cl 2 (26.3 mg, mmol, 1.0 mol %) and CuI (14.3 mg, mmol, 2.0 mol %) in Et 3N/Dioxane (1:1, 3.0 ml) as well as propargyl alcohol (262.0 µl, mmol, 1.2 eq.) were added and the resulting reaction was stirred at r.t. After stirring for 2 h, the reaction mixture was poured into water and extracted with CH 2Cl 2, then the combined organic phases were concentrated in vacuo and purified by column chromatography (silica gel, 40 % EtOAc in hexane) to afford the product AA-CW514 (402.0 mg, 72 % yield) as a white solid. 1 H NMR (400 MHz, MeOD) δ 7.25 (d, J = 8.6 Hz, 2H), 6.74 (d, J = 8.6 Hz, 2H), 4.37 (s, 2H); 13 C NMR (100 MHz, MeOD) δ , , , , 85.21, 84.62, HRMS (ESI) m/z Calculated for C 9H 9O 2 (M+H) + : , found: To a stirred solution of 4-(3-hydroxyprop-1-yn-1-yl)phenol (124.5 mg, mmol, 1.0 eq.) in isopropanol (5.0 ml), a 2 M solution of NaOH (84.0 mg, mmol, 2.5 eq.) in water (1.05 ml) was added. After vigorously stirring for 5 min., Ac 2O (198.5 µl, mmol, 2.5 eq.) was added and the resulting reaction mixture was stirred at r.t. overnight. After that, the reaction mixture was poured into water and extracted with CH 2Cl 2, then the combined organic phases were concentrated in vacuo and purified by column chromatography (silica gel, 20 % EtOAc in hexane) to afford the product AA-CW521 (160.0 mg, 82 % yield) as a slightly yellow oil. 1 H NMR (400 MHz, CDCl 3) δ 7.46 (d, J = 8.5 Hz, 2H), 7.05 (d, J = 8.5 Hz, 2H), 4.88 (s, 2H), 2.29 (s, 3H), 2.12 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , 85.62, 83.06, 52.76, 21.12, HRMS (ESI) m/z Calculated for C 13H 13O 4 (M+H) + : , found: A screw-cap tube was charged with Cp*Ru(PPh 3) 2Cl (2.4 mg, mmol, 2.0 mol %), evacuated and filled with N 2 (3 times). Then dry PhMe (1.5 ml), 3-(4-acetoxyphenyl)prop-2- yn-1-yl acetate (41.8 mg, mmol, 1.2 eq.) and 4-(2-azidoethyl)-3,5-dimethylisoxazole (25.0 mg, mmol, 1.0 eq.) were added in sequence. The reaction tube was screw-capped and left overnight under stirring at 80 C in an oil bath. After that, the reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, 60 % 70 % EtOAc in hexane) to give the product AA-CW532A (36.7 mg, 61 % yield) as a colorless oil. 1 H NMR (400 MHz, CDCl 3) δ 7.73 (d, J = 8.7 Hz, 2H), 7.18 (d, J = 8.7 Hz, 2H), 4.95 (s, 2H), 4.52 (t, J = 6.7 Hz, 2H), 2.98 (t, J = 6.7 Hz, 2H), 2.30 (s, 3H), 2.12 (s, 3H), 2.06 (s, 3H), 2.04 (s, 3H); S21

22 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , , 52.68, 48.02, 23.64, 21.15, 20.66, 10.41, HRMS (ESI) m/z Calculated for C 20H 23N 4O 5 (M+H) + : , found: To a stirred solution of 4-(5-(acetoxymethyl)-1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-1H-1,2,3- triazol-4-yl)phenyl acetate (36.7 mg, mmol, 1.0 eq.) in CH 2Cl 2 (2.0 ml), pyrrolidine (76.9 µl, mmol, 10.0 eq.) was added and the resulting reaction mixture was stirred at r.t. for 20 min. The reaction mixture was quenched with 1 M HCl and extracted with CH 2Cl 2, the combined organic phases were concentrated in vacuo and purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) to give the product AA-CW534 (32.5 mg, 99 % yield) as a white solid. 1 H NMR (400 MHz, CDCl 3) δ 7.50 (d, J = 8.4 Hz, 2H), 6.94 (d, J = 8.5 Hz, 2H), 4.95 (s, 2H), 4.53 (t, J = 6.6 Hz, 2H), 2.99 (t, J = 6.6 Hz, 2H), 2.13 (s, 3H), 2.08 (s, 6H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 52.88, 48.10, 23.59, 20.71, 10.46, HRMS (ESI) m/z Calculated for C 18H 21N 4O 4 (M+H) + : , found: To a stirred solution of (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-(4-hydroxyphenyl)-1H-1,2,3- triazol-5-yl)methyl acetate (15.0 mg, mmol, 1.0 eq.) in dry DMF (0.6 ml), K 2CO 3 (7.0 mg, mmol, 1.2 eq.) was added, followed by the addition of propargyl bromide (4.4 µl, 80 wt. % in PhMe, mmol, 1.2 eq.). The resulting reaction mixture was stirred at r.t. for 6 h. After that, the reaction mixture was diluted with EtOAc and washed with water. The organic phase was concentrated in vacuo and purified by column chromatography (silica gel, 50 % EtOAc in hexane) to give the product AA-CW536 (15.1 mg, 91 % yield) as a colorless oil. 1 H NMR (400 MHz, CDCl 3) δ 7.66 (d, J = 8.4 Hz, 2H), 7.07 (d, J = 8.3 Hz, 2H), 4.94 (s, 2H), 4.74 (d, J = 1.3 Hz, 2H), 4.53 (t, J = 6.6 Hz, 2H), 3.00 (t, J = 6.6 Hz, 2H), 2.55 (s, 1H), 2.14 (s, 3H), 2.09 (s, 3H), 2.06 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , , 78.30, 75.82, 55.85, 52.81, 47.98, 23.69, 20.71, 10.43, HRMS (ESI) m/z Calculated for C 21H 23N 4O 4 (M+H) + : , found: S22

23 To a stirred solution of (1-(2-(3,5-dimethylisoxazol-4-yl)ethyl)-4-(4-(prop-2-yn-1-yloxy)phenyl)- 1H-1,2,3-triazol-5-yl)methyl acetate (15.0 mg, mmol, 1.0 eq.) in MeOH (0.5 ml), K 2CO 3 (10.5 mg, mmol, 2.0 eq.) was added and the resulting reaction was stirred at r.t. After stirring for 0.5 h, the reaction mixture was diluted with water and extracted with CH 2Cl 2. The combined organic phases were concentrated in vacuo and dried over MgSO 4 to give the product AA-CW537 as a white solid. 1 H NMR (400 MHz, CDCl 3) δ 7.54 (d, J = 8.5 Hz, 2H), 7.04 (d, J = 8.5 Hz, 2H), 4.72 (d, J = 2.2 Hz, 2H), 4.61 (s, 2H), 4.49 (t, J = 6.9 Hz, 2H), 2.99 (t, J = 6.9 Hz, 2H), 2.54 (t, J = 2.1 Hz, 1H), 2.15 (s, 3H), 2.11 (s, 3H). HRMS (ESI) m/z Calculated for C 19H 21N 4O 3 (M+H) + : , found: Then to a stirred solution of (1-(2-(3,5- dimethylisoxazol-4-yl)ethyl)-4-(4-(prop-2-yn-1-yloxy)phenyl)-1h-1,2,3-triazol-5-yl)methanol (AA-CW537) in dry CH 2Cl 2 (2.0 ml) cooled in an ice bath, Et 3N (7.9 µl, mmol, 1.5 eq.) was added, followed by the addition of MsCl (4.4 µl, mmol, 1.5 eq.). The reaction was stirred at 0 C for 0.5 h and then at r.t. for 0.5 h. After that n Bu 4NCl (15.8 mg, mmol, 1.5 eq.) was added and the reaction was stirred at r.t. for 1 h. The reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, CH 2Cl 2, then EtOAc) to give the product 20 (11.6 mg, 82 % yield for two steps) as a white solid. 1 H NMR (400 MHz, CDCl 3) δ 7.62 (d, J = 8.8 Hz, 2H), 7.10 (d, J = 8.8 Hz, 2H), 4.75 (d, J = 2.4 Hz, 2H), 4.49 (s, 2H), 4.45 (t, J = 7.1 Hz, 2H), 3.07 (t, J = 7.1 Hz, 2H), 2.55 (t, J = 2.4 Hz, 1H), 2.21 (s, 3H), 2.16 (s, 3H); 13 C NMR (100 MHz, CDCl 3) δ , , , , , , , , , 78.24, 75.87, 55.87, 47.93, 32.59, 23.45, 10.67, HRMS (ESI) m/z Calculated for C 19H 20ClN 4O 2 (M+H) + : , found: Cell culture and preparation of lysates MCF7, MDA-MB-231, HeLa, Caco-2 and A431 cells were maintained in DMEM media. HCC 1187 and RPMI 8402 cells were cultured in RPMI-1640 media. All media were supplemented with 10% fetal calf serum (FCS), non-essential amino acids and penicillin streptomycin. Cells were grown at 37 C under 5% CO 2 atmosphere. Adherent cells were allowed to grow to confluence and were harvested by scraping, centrifuged at x g for five min. at 4 C and resuspended in PBS. Cells in suspension were centrifuged at x g for five min. at 4 C, washed one time with PBS and resuspended in PBS after centrifugation. Cells were lysed by sonication to form cell lysates and protein concentration was determined using the Bradford assay. Preparation of proteomes for SDS-PAGE experiments Lysate (2 mg/ml, 50 µl) was treated with indicated compound (1 µl of 50x stock in DMSO) or DMSO for one hour at r.t. Sample was then treated with either 10 µm AA-CW159A or 30 µm S23

24 AA-CW538 (1 µl of 50x stock in DMSO) for one hour at r.t. Click chemistry was initiated by the addition of TAMRA alkyne (Jena Bioscience, 10 µm, 25x stock in DMSO) or TAMRA azide (Sigma-Aldrich, 50 µm, 25x stock in DMSO), tris(2-carboxyethyl)phosphine hydrochloride (TCEP, Alfa Aesar, 1 mm, fresh 50x stock in water), tris[(1-benzyl-1h-1,2,3-triazol-4- yl)methyl]amine (TBTA, Sigma-Aldrich, 100 µm, 16x stock in DMSO:tButanol 1:4), and copper(ii) sulfate (1 mm, 50x stock in water) to the lysate and incubated in the dark for one hour at r.t. SDS-PAGE reducing loading buffer (4x) was added and proteins were separated using a 10-12% SDS-PAGE gel. Gels were visualized at 625 nm using a Hitachi FMBIO II Multi-View fluorescence scanner, then stained using Coomassie. Images were quantified with ImageJ. Cloning and site-directed mutagenesis The hmgmt-wt gene was amplified from a cdna library derived from HeLa cells and flanked with Attb-sites using the following primer: forward 5 -GGG GAC AAG TTT GTA CAA AAA AGC AGG CTC CAT GGA CAA GGA TTG TGA AAT G-3 and reverse 5 -GGG GAC CAC TTT GTA CAA GAA AGC TGG GTT CAG TTT CGG CCA GCA G-3. The R reaction was cleaned up and the R product recombined into the pdonr 221. This pentr was used for R based site directed mutagenesis to generate the mutated pentr vector hmgmt-c145a-pentr (forward primer: 5 CTC ATC CCG GCC CAC AGA GTG 3 ; reverse primer: 5 CAC TCT GTG GGC CGG GAT GAG 3 ). Afterwards the R reaction was incubated with DpnI (New England BioLabs Inc, 37 C, 12 hours) to degrade hmgmt-wt-pentr. The two entry vectors were used for transferring the hmgmt-wt and hmgmt-c145a genes into the pcdna 6.2 N- EmGFP-DEST vector via the LR reaction to merge the emgfp gene to the 5 of each hmgmt gene. The pentr and pexp plasmids were propagated via transformation into E. coli DH5α strain using heat shock. Transfection and Western blot HeLa or MCF7 cells were seeded in a Petri dish, left to attach and grow to 80% confluence. Cells were transfected with either GFP-hMGMT-WT, GFP-hMGMT-C145A or GFP plasmid using Lipofectamine 2000 (Invitrogen). After 24 hours, lysate was prepared and treated as described above. Click chemistry, reducing SDS-PAGE and visualization were performed as described above. Proteins were transferred to a nitrocellulose membrane using a Trans-Blot Turbo transfer system (Bio-Rad). Membrane was blocked with 5% milk in Tris-Buffered Saline with 0.1% Tween (TBST) for 30 min. Mouse monoclonal antibody against GFP (Roche, 1/1000 in 5% milk in TBST) was added and incubated overnight at 4 C. Membrane was washed three times for five min. with TBST and incubated with anti-mouse HRP antibody (GE Healthcare, 1/2000 in 5% milk in TBST) for one hour at r.t. Membrane was washed three times for five min. with TBST and visualized with a Fusion Solo (Vilber Lourmat) after ECL (Witec AG). Gel-based MGMT kinetics Recombinant human MGMT (Cayman Chemical, 20 ng in PBS, 25 µl) was treated with indicated concentrations of coumpounds (0.5 µl of 50x stock in DMSO) for 10, 20, 30, 40, 50 or 60 min. Samples were then treated with 10 µm AA-CW159A (0.5 µl of 50x stock in DMSO) for one hour. Click chemistry, reducing SDS-PAGE and visualization were performed as described above. Images were quantified with ImageJ and the kinectics values were calculated using GraphPad Prism (V6.03). In-situ labeling experiments MCF7 cells were seeded ( cells/ml) in a 6 cm Petri dish and left two days to attach and grow. The plates were washed one time with PBS and AA-CW236 or DMSO was added at indicated concentrations (1000x stock in DMSO) in culture media and incubated for S24

25 10 hours. Lysate was prepared as described above and treated with 30 µm AA-CW538 (50x stock in DMSO) for one hour. Click chemistry, reducing SDS-PAGE and visualization were performed as described above. Visualization of DNA alkylation MCF7 cells were seeded ( cells/ml) in a 24-well plate containing a coverslip and left two days to attach and grow. Cells were incubated for 12 hours with either 1 µm AA-CW236, 1 µm lomeguatrib (1000x stock in DMSO) or DMSO. Media was replaced with fresh compound and after 30 min, water or 300 µm temozolomide (10x fresh solution in water) was added and incubated for 8 hours. Cells were washed two times with PBS and fixed with methanol at 20 C for 30 min. Cells were again washed two times with PBS and coverslip was transferred to a wet box. Cells were treated with a 4 C solution of 70 mm NaOH, 140 mm NaCl and 40% ethanol for five min. [6] and then washed three times with PBS. Blocking was performed with a 5% bovine serum albumin (BSA) solution in PBS for 30 min. Cells were washed one time with PBS 0.1% BSA and mouse monoclonal O 6 -methyl-2-deoxyguanosine-directed antibody (Axxora, 1/500 in PBS 0.1% BSA) was added and incubated for two hours at r.t. Cells were washed three times with PBS 0.1% BSA and incubated for one hour with anti-mouse IgG alexa fluor 488 (Jackson, 1/200 in PBS 0.1% BSA). Cells were washed three times with PBS 0.1% BSA, one time with PBS, one time with water and then mounted on a slide with ProLong Gold antifade mountant with DAPI (Life Technologies). Cells were visualized with an LSM 700 confocal microscope (Zeiss). Cell viability assay Caco-2 cells were seeded in a 96-well plate ( cells/ml) and were allowed to attach overnight. Cells were pre-incubated with DMSO or 3 µm AA-CW236 for 8 hours (1000x stock in DMSO) followed by the addition of indicated concentrations of temozolomide (10x stock in water) and incubated for 5 days. Cells were imaged using a SpectraMax i3 plate reader equipped with a SpectraMax MiniMax imaging cytometer (Molecular Devices) and counted with ImageJ. SILAC labeling of MCF7 cells MCF7 cells were passaged 6 times in DMEM without L-lysine and L-arginine (Thermo Scientific) supplemented with 10% dialyzed FCS (Thermo Scientific), non-essential amino acids, penicillin streptomycin and either 100 mg/l 13 C 6 L-lysine-HCl and 13 C 6 15 N 4 L-arginine- HCl (heavy) or L-lysine-HCl and L-arginine-HCl (light) (Thermo Scientific). AA-CW159A enrichment for mass spectrometry MCF7 lysate (2 mg/ml, 0.5 ml) was treated with DMSO or 10 µm AA-CW159A (100x stock in DMSO) for one hour at r.t. Protein was subjected to click chemistry. Photocleavable () biotin alkyne (Click Chemistry Tools, 20 µm, 50x stock in DMSO), tris(2-carboxyethyl)phosphine hydrochloride (TCEP) (1 mm, 50x fresh stock in water), tris[(1-benzyl-1h-1,2,3-triazol-4- yl)methyl]amine (TBTA) (100 µm, 16x stock in DMSO:tButanol 1:4), and copper(ii) sulfate (1 mm, 50x stock in water) were added to the proteome and left to react for one hour at r.t. Protein was precipitated by adding MeOH (4 vol.), CHCl 3 (1 vol.) and water (3 vol.) to the reaction mixture and the turbid mixture was centrifuged for five min. at x g at 4 C yielding a protein layer between the aqueous and organic layers. The protein layer was isolated, dried and solubilized in 2% SDS in PBS via sonication. Tube was centrifuged at x g for five min. and soluble fraction was transferred to a new tube. PBS was added to give a final SDS concentration of 0.2%. 70 µl of streptavidin agarose beads (ProteoChem) were added and the mixture was rotated for four hours at r.t. Beads were washed with 1% SDS in PBS (1x 10 ml), S25

26 PBS (3x 10 ml), and water (3x 10 ml). Beads were resuspended in 6 M urea in PBS (500 μl), reduced with 10 mm neutralized TCEP (20x fresh stock in water) for 30 min. at r.t., and alkylated with 55 mm iodoacetamide (400 mm fresh stock in water) for 30 min. at r.t. in the dark. Beads were pelleted by centrifugation (1 400 x g, two min.) and resuspended in 150 μl of 2 M Urea, 1 mm CaCl 2 (100x stock in water) and trypsin (Promega, 1 μl of 0.5 μg/μl) in 50 mm NH 4HCO 3. The digestion was performed for 12 hours at 37 C. Samples were acidified to a final concentration of 5% acetic acid, desalted over a self-packed C18 spin column and dried. Samples were analyzed by LC-MS/MS (see below) and the MS data was processed with MaxQuant (see below). AA-CW159A-competitive SILAC experiment MCF7 light and heavy lysates (2 mg/ml, 0.5 ml) were treated with indicated concentration of AA-CW236 (100x stock in DMSO) or DMSO for one hour. Lysate was then treated with 10 µm AA-CW159A (100x stock in DMSO) for one hour at r.t. Protein was subjected to click chemistry. Photocleavable () biotin alkyne (Click Chemistry Tools, 20 µm, 50x stock in DMSO), tris(2- carboxyethyl)phosphine hydrochloride (TCEP) (1 mm, 50x fresh stock in water), tris[(1-benzyl- 1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) (100 µm, 16x stock in DMSO:tButanol 1:4), and copper(ii) sulfate (1 mm, 50x stock in water) were added to the proteome and left to react for one hour at r.t. Light and heavy proteomes were mixed together at a ratio of 1:1. Protein was precipitated by adding MeOH (4 vol.), CHCl 3 (1 vol.) and water (3 vol.) to the reaction mixture and the turbid mixture was centrifuged for five min. at x g at 4 C yielding a protein layer between the aqueous and organic layers. The protein layer was isolated, dried and solubilized in 2% SDS in PBS via sonication. Tube was centrifuged at x g for five min. and soluble fraction was transferred to a new tube. PBS was added to give a final SDS concentration of 0.2%. 140 µl of streptavidin agarose beads (ProteoChem) were added and the mixture was rotated for four hours at r.t. Beads were washed with 1% SDS in PBS (1x 10 ml), PBS (3x 10 ml), and water (3x 10 ml). Beads were resuspended in 6 M urea in PBS (500 μl), reduced with 10 mm neutralized TCEP (20x fresh stock in water) for 30 min. at r.t., and alkylated with 55 mm iodoacetamide (400 mm fresh stock in water) for 30 min. at r.t. in the dark. Beads were pelleted by centrifugation (1 400 x g, two min.) and resuspended in 150 μl of 2 M Urea, 1 mm CaCl 2 (100x stock in water) and trypsin (Promega, 1 μl of 0.5 μg/μl) in 50 mm NH 4HCO 3. The digestion was performed for 12 hours at 37 C. Samples were acidified to a final concentration of 5% acetic acid, desalted over a self-packed C18 spin column and dried. Samples were analyzed by LC-MS/MS (see below) and the MS data was processed with MaxQuant (see below). IAA-competitive dimethyl labeling experiment MCF7 lysate (2 mg/ml, 5 ml) was treated with 200 nm of AA-CW236 or lomeguatrib (100x stock in DMSO) or DMSO for one hour. Sample was then incubated with 10 µm iodoacetamide alkyne (Setareh Biotech, 100x stock in DMSO) for one hour. Photocleavable () biotin azide (Click Chemistry Tools, 20 µm, 50x stock in DMSO), tris(2-carboxyethyl)phosphine hydrochloride (TCEP) (1 mm, 50x fresh stock in water), tris[(1-benzyl-1h-1,2,3-triazol-4- yl)methyl]amine (TBTA) (100 µm, 16x stock in DMSO:tButanol 1:4), and copper(ii) sulfate (1 mm, 50x stock in water) were added to the proteome and left to react for one hour at r.t. Protein was precipitated by adding MeOH (4 vol.), CHCl 3 (1 vol.) and water (3 vol.) to the reaction mixture and the turbid mixture was centrifuged for 10 min. at x g at 4 C yielding a protein layer between the aqueous and organic layers. The protein layer was isolated, dried and solubilized in 2% SDS in PBS via sonication. Tube was centrifuged at x g for five min. and soluble fraction was transferred to a new tube. PBS was added to give a final SDS concentration of 0.2%. 500 µl of streptavidin agarose beads were added and the mixture was rotated for four hours at r.t. Beads were washed with 1% SDS in PBS (2x 10 ml), PBS (3x 10 ml), and water (3x 10 ml). Beads were resuspended in 6 M urea in PBS S26

27 (500 μl), reduced with 10 mm neutralized TCEP (20x fresh stock in water) for 30 min. at r.t., and alkylated with 55 mm iodoacetamide (400 mm fresh stock in water) for 30 min. at r.t. in the dark. Beads were pelleted by centrifugation (1 400 x g, two min.) and resuspended in 300 μl of 2 M Urea, 1 mm CaCl 2 (100x stock in water) and trypsin (Promega, 2 μl of 0.5 μg/μl) in 50 mm NH 4HCO 3. The digestion was performed for 12 hours at 37 C. Beads were washed with 1% SDS in PBS (1x 10 ml), PBS (3x 10 ml), and water (3x 10 ml). Beads were transferred to a microtube in 500 μl of 100 mm tetraethylammonium bromide (TEAB) buffer, centrifuged (1 400 x g, 2 min.) and resuspended in 500 μl of 100 mm TEAB buffer. Dimethyl labeling was performed as reported previously [7]. Briefly, 20 μl of either 4% formaldehyde or 4% formaldehyde-d 2 solution was added together with 20 μl of 0.6 M NaBH 3CN (freshly made in water) and left to react for one hour at r.t. with rotation. Beads were washed three times with PBS and mixed at a ratio 1:1. Beads were resuspended in 2 ml PBS and photocleavage was performed with irradiation at 365 nm in a CL-1000 UV crosslinker (UVP) for one hour at 4 C. Beads were centrifuged and supernatant was transferred to a new tube. Beads were resuspended in 1 ml PBS and incubated for one hour at 37 C with shaking, centrifuged and supernatants were combined. Beads were resuspended in 1 ml PBS with 1 M NaCl and incubated for 6 hours with shaking, centrifuged and supernatants were combined. Peptides were desalted over a self-packed C18 spin column and dried. Samples were analyzed by LC- MS/MS (see below) and the MS data was processed with MaxQuant (see below) and Proteome Discoverer (see below). LC-MS/MS analysis Peptides were resuspended in water with 0.1% formic acid (FA) and analyzed using Proxeon EASY-nLC 1000 nano-uhplc coupled to QExactive Plus Quadrupole-Orbitrap mass spectrometer (Thermo Scientific). The chromatography column consisted of a 30 cm long, 75 μm i.d. microcapillary capped by a 5 μm tip and packed with ReproSil-Pur 120 C18-AQ 2.4 μm beads (Dr. Maisch GmbH). LC solvents were 0.1% FA in H 2O (Buffer A) and 0.1% FA in MeCN (Buffer B). Peptides were eluted into the mass spectrometer at a flow rate of 300 nl/min. over a 240 min. linear gradient (3-35% Buffer B) at 50 C. Data was acquired in data-dependent mode (top-20, NCE 30, R = ) after full MS scan (R = , m/z ). Dynamic exclusion was set to 10 s, peptide match to prefer and isotope exclusion was enabled. MaxQuant analysis The MS data was analyzed with MaxQuant [8] (V ) and searched against the human proteome (Uniprot, 89,649 entries) and a common list of contaminants (included in MaxQuant). The first peptide search tolerance was set at 20 ppm, 10 ppm was used for the main peptide search and fragment mass tolerance was set to 0.02 Da. The false discovery rate for peptides, proteins and sites identification was set to 1%. The minimum peptide length was set to 6 amino acids, minimal number of peptides per protein was set to 2 and peptide requantification was enabled. Oxidized methionine was set as variable modification and carbamidomethylation of cysteine as fixed modification. For competitive ABPP-SILAC experiments 13 C 6 L-lysine and 13 C 6, 15 N 4 L-arginine were set as heavy isotope labels. For IAA-competitive capture-andrelease experiments, iodoacetamide alkyne adduct ( Da) and carbamidomethylation on cysteine and oxidation of methionine were set as variable modifications. Dimethyl labels were searched as N-terminal and lysine modification for light Da and heavy Da. Only modified peptides with PEP value 1% and present in 4 out of 6 injections were considered. Proteome Discoverer analysis The MS data was analyzed with Proteome Discoverer (V ) using the Sequest HT algorithm [9] and searched against the human proteome (Uniprot, 89,649 entries). Dimethyl S27

28 labels were searched as N-terminal and lysine modification for light Da and heavy Da. Iodoacetamide alkyne adduct ( Da), carbamidomethylation on cysteine and oxidation of methionine were set as dynamic modification. Maximum precursor mass was set to Da, precursor mass tolerance to 10 ppm and fragment mass tolerance to 0.02 Da. Only modified peptides with PEP value 1% were considered. hmgmt docking studies AA-CW236, 8, 9 and 11 were covalently docked to the crystal structure of human MGMT (PDB: 1EH6) on Cys 145 using the GOLD suite (v5.3, CCDC). The default GOLD fitness function was used to determine the best binding configuration. The distance for hydrogen bonding was set to 3 Å and the minimun H-bond geometry weight to 0.5. S28

29 Supplemental Figures kda ( ) (+) IAA (10 mm) (+) (+) AA-CW159A (10 µm) kda ( ) (+) IAA (10 mm) (+) (+) AA-CW159A (10 µm) Figure S1: Gel-based fluorescence image of MCF7 cell lysate pretreated or not with 10 mm iodoacetamide and labeled with 10 µm AA-CW159A (left). The Coomassie stain image is shown on the right side. S29

30 kda AA-CW159A Mock Overexpr. kda AA-CW159A Mock Overexpr GFP-hMGMT 50- -GFP-hMGMT Figure S2: Gel-based fluorescence labeling of mock-transfected MCF7 cell lysate and lysate with overexpressed GFP-hMGMT and labeled with 10 µm AA-CW159A (left). The Coomassie stain image is shown on the right side. S30

31 Mock DMSO DMSO DMSO kda kda kda Figure S3: Coomassie stain images corresponding to the fluorescence gels in Figure 2B. S31

32 19 14 A B Mock (nm) (nm) kda 250- kda GFP-hMGMT GFP-hMGMT Mock (nm) kda kda (nm) C 25- Figure S4: Fluorescence gels of mock-transfected MCF7 cell lysate and lysates with overexpressed GFP-hMGMT. Lysates were treated with indicated concentrations of 19 (A, top) or 14 (B, top) followed by 10 µm AA-CW159A. Corresponding Coomassie stain images are shown (A and B, bottom). Determination of the IC 50 values of compounds 19 and 14 against GFP-hMGMT (C). S32

33 AA-CW236 - lomeguatrib Figure S5: Determination of the binding constants K I and k inact for AA-CW236, O 6 - benzylguanine and lomeguatrib against human MGMT. S33

34 Scheme S1: Synthesis of clickable probe 20 (AA-CW538) S34

35 MCF7 breast adenocarcinoma MDA-MB-231 breast adenocarcinoma HCC 1187 breast carcinoma HeLa cervix carcinoma Caco-2 colon adenocarcinoma A431 squamous cell carcinoma RPMI 8402 acute lymphoblastic leukemia ( ) (+) ( ) (+) ( ) (+) ( ) (+) ( ) (+) ( ) (+) ( ) (+) AA-CW236 kda Figure S6: Coomassie stain image corresponding to the fluorescence gel in Figure 3C. S35

36 kda AA-CW AA-CW236 (nm) kda AA-CW AA-CW236 (nm) endog. MGMT Figure S7: Gel-based profiling of AA-CW236 activity in-situ. MCF7 cells were treated with various concentrations of AA-CW236 for 10 hours, lysed and treated with 30 µm AA-CW538. Fluorescence gel is shown on the left side and the Coomassie stain image on the right side. S36

37 L o g 2 D M L R a tio L o m e g u a trib /D M S O D N M 2 P G K 1 R a tio G N B M G M T M R P S 1 8 C R A R S L o m e g u a trib n M Figure S8: Scatter plot with DML ratios from the competitive experiment with 200 nm lomeguatrib (n = 6) followed by 10 µm IAA alkyne. The complete list of peptides and ratios is shown in Table S5. S37

38 A (nm) endog. MGMT- AA-CW236 B C endog. MGMT- endog. MGMT- AA-CW236-2 AA-CW236-3 D AA-CW236 AA-CW236-2 AA-CW (nm) Figure S9: (A) Fluorescence gels of MCF7 lysates treated with indicated concentrations of AA-CW236, AA-CW236-2 or AA-CW236-3 followed by 30 µm AA- CW538. (B) Chemical structures of AA-CW236, AA-CW236-2 and AA-CW (C) Determination of IC 50 values for compounds AA-CW236, AA-CW236-2 and AA-CW236-3 against endogenous hmgmt. (D) Corresponding Coomassie stain images. S38

39 1 µm lomeguatrib 1 µm AA-CW236 DMSO A B C DAPI Anti-O 6 -MeG DAPI Anti-O 6 -MeG DAPI Anti-O 6 -MeG Figure S10: Representative fluorescence images from MCF7 cells treated with either DMSO, 1 µm AA-CW236 or 1 µm lomeguatrib for 12 h followed by 300 µm TMZ for 8 h. DAPI staining is shown in blue and guanine O 6 -alkylation staining is shown in green. Different independent experiments are shown in columns A-C. White bars indicate 10 μm. S39

40 C e ll v ia b ility (% ) A A -C W IC 5 0 = 8.6 M C o n c e n tra tio n ( M ) Figure S11: Caco-2 cell viability curve after treatment with various concentration of AA- CW236 for 5 days. S40

41 Supplemental Tables Table S1: Protein enrichment with 10 µm AA-CW159A treatment. Protein IDs Protein names Gene names P49588 Alanine--tRNA ligase, cytoplasmic AARS P80404;H3BRN4;H3BNQ7 4-aminobutyrate aminotransferase, ABAT F5GYC1;P28288;E7EUE1;P ATP-binding cassette sub-family D member 3 ABCD3 Q8NFV4;Q8NFV4-4;Q8NFV4-6 Alpha/beta hydrolase domain-containing protein 11 ABHD11 Q8N2K0;Q8N2K0-2;Q8N2K0-3 Monoacylglycerol lipase ABHD12 ABHD12 P09110;C9JDE9;H7C131;P ketoacyl-CoA thiolase, peroxisomal ACAA1 P42765;K7EME0 3-ketoacyl-CoA thiolase, ACAA2 Q13085;Q ;Q ;Q Acetyl-CoA carboxylase 1;Biotin carboxylase ACACA Q9H845;H0Y8Z9 Acyl-CoA dehydrogenase family member 9, ACAD9 P ;P49748;P Very long-chain specific acyl-coa dehydrogenase, ACADVL P24752 Acetyl-CoA acetyltransferase, ACAT1 Q9BWD1;B7Z233 Acetyl-CoA acetyltransferase, cytosolic ACAT2 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3T3;G3V3B0;Q9UKV3-3;Q9UKV3-2 Apoptotic chromatin condensation inducer in the nucleus ACIN1 P ;P53396;B4E3P0 ATP-citrate synthase ACLY Q99798;A2A274 Aconitate hydratase, ACO2 O ;O ;O ;O ;O00154;F5GWE2;O ;B4DUX0;K7EKP8;O Cytosolic acyl coenzyme A thioester hydrolase ACOT7 Q ;Q ;Q15067 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 E9PF16;B4DHT5;Q96CM8;B4DFQ6;B4DUF5 Acyl-CoA synthetase family member 2, ACSF2 P60709;Q5T8M7 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N- terminally processed ACTB;ACTA1 S41

42 P68032;P63267;P62736;P68133;Q5T8M8;A6NL76 ;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 Actin, alpha cardiac muscle 1;Actin, gammaenteric smooth muscle;actin, aortic smooth muscle;actin, alpha skeletal muscle ACTC1;ACTG2;ACTA2;ACT A1 P63261 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N- terminally processed ACTG1 P63261;P60709 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N- terminally processed;actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed ACTG1;ACTB O ;O96019;H7C5S0 Actin-like protein 6A ACTL6A P ;P12814;P ;P ;H9KV75 Alpha-actinin-1 ACTN1 O43707;O ;O ;F5GXS2 Alpha-actinin-4 ACTN4 P61160;P ;F5H6T1 Actin-related protein 2 ACTR2 P61158;B4DXW1;F5H3P5 Actin-related protein 3 ACTR3 P ;P55265;P ;E7ENU4;P ;H0YCK3;P Double-stranded RNA-specific adenosine deaminase ADAR Q9BV57;Q9BV57-2 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Q9H2P0 Activity-dependent neuroprotector homeobox protein ADNP Q16186 Proteasomal ubiquitin receptor ADRM1 ADRM1 O95994;Q4JM47;B5MC07;C9J3E2;H7C3Z9 Anterior gradient protein 2 homolog AGR2 Q8TD06;H7C040;B5MC62 Anterior gradient protein 3 homolog AGR3 P23526;P Adenosylhomocysteinase AHCY Q09666 B4DUR9;O95433;H0YJ63;G3V438;H0YJG7 Neuroblast differentiation-associated protein AHNAK Activator of 90 kda heat shock protein ATPase homolog 1 AHNAK AHSA1 O ;O95831;O Apoptosis-inducing factor 1, AIFM1 Q13155;A8MU58;F8W950 Aminoacyl trna synthase complex-interacting multifunctional protein 2 AIMP2 P ;P ;F8W1A4;P54819;F8VY04;P ;G3V213;F8VZG5;P Adenylate kinase 2, ;Adenylate kinase 2,, N-terminally processed AK2 B4DK69;P52895;S4R3P0;Q04828;H0Y804 Aldo-keto reductase family 1 member C2 AKR1C2;AKR1C1 H3BLU7;O43488 Aflatoxin B1 aldehyde reductase member 2 AKR7A2 P13716;P Delta-aminolevulinic acid dehydratase ALAD S42

43 P ;P54886 Delta-1-pyrroline-5-carboxylate synthase;glutamate 5-kinase;Gamma-glutamyl phosphate reductase ALDH18A1 J3QS00;I3L1M4;J3QRD1;P51648;P Fatty aldehyde dehydrogenase ALDH3A2 C9J8Q5;P51649;P ;F5H328 Succinate-semialdehyde dehydrogenase, ALDH5A1 J3KNU8;Q02252;G3V4Z4 Methylmalonate-semialdehyde dehydrogenase [acylating], ALDH6A1 P ;P49419;F8VS02;P ;P Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 P04075;J3KPS3;P ;H3BQN4;H3BPS8;H3BUH7;H3BR04 Fructose-bisphosphate aldolase A;Fructosebisphosphate aldolase ALDOA P09972;K7EKH5;C9J8F3;J3KSV6;J3QKP5;A8MV Z9 Fructose-bisphosphate aldolase C;Fructosebisphosphate aldolase ALDOC Q9Y4X0-3;Q9Y4X0;Q9Y4X0-4 AMME syndrome candidate gene 1 protein AMMECR1 Q ;Q92688;Q5T6W8 Acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B P ;P50995;H0Y6E1 Annexin A11 ANXA11 P07355;P ;H0YN42;H0YMD0;H0YMU9;A6NMY6;H0YM50;H 0YKS4;H0YNP5;H0YN28;H0YL33 Annexin A2;Annexin;Putative annexin A2-like protein ANXA2;ANXA2P2 P08758;D6RBL5;D6RBE9 Annexin A5;Annexin ANXA5 P ;P20073 Annexin A7 ANXA7 Q ;Q ;Q ;Q10567;C9J1E7 AP-1 complex subunit beta-1 AP1B1 O43747;O ;J3KQU9;B3KXW5 AP-1 complex subunit gamma-1 AP1G1 P61966;H7C1E4;P AP-1 complex subunit sigma-1a AP1S1 O ;O95782 AP-2 complex subunit alpha-1 AP2A1 P63010;P ;P ;K7EJT8 AP-2 complex subunit beta AP2B1 Q96CW1-2;Q96CW1;E9PFW3;C9JJ47 AP-2 complex subunit mu AP2M1 P13798;C9JIF9;H7C1U0;C9JLK2;H7C393 Acylamino-acid-releasing enzyme APEH P27695;G3V5Q1;G3V3M6;G3V5D9;G3V3C7 DNA-(apurinic or apyrimidinic site) lyase;dna- (apurinic or apyrimidinic site) lyase, APEX1 Q9BZZ5-3;Q9BZZ5-2;G3V1C3;Q9BZZ5;E9PQK6;Q9BZZ5-5;B4E283 Apoptosis inhibitor 5 API5 Q9HDC9-2;H0Y512;Q9HDC9 Adipocyte plasma membrane-associated protein APMAP S43

44 H3BSW3;P ;H3BQF1;H3BQZ9;P07741;H3BQB1 Adenine phosphoribosyltransferase APRT P48444;B0YIW6;P Coatomer subunit delta ARCN1 P84077;P61204;F5H423;F5H0C7 J3KTF8;P52565;J3QQX2;J3KRE2;J3KS60;P ;J3KRY1 ADP-ribosylation factor 1;ADP-ribosylation factor 3 Rho GDP-dissociation inhibitor 1 ARF1;ARF3 ARHGDIA B4DWW1;P40616;F8VYN9;B4DZG7 ADP-ribosylation factor-like protein 1 ARL1 Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B Q9NVT9;B4E2W7;E5RJ86 Armadillo repeat-containing protein 1 ARMC1 Q92747;E9PF58;B4DLQ7 Actin-related protein 2/3 complex subunit 1A AR1A O15143 Actin-related protein 2/3 complex subunit 1B AR1B O15144 Actin-related protein 2/3 complex subunit 2 AR2 P59998;F8WCF6;F8WDD7;P ;P ;H7C0A3 O ;O95671;E7ER97;O Actin-related protein 2/3 complex subunit 4 N-acetylserotonin O-methyltransferase-like protein AR4;AR4-TTLL3 ASMTL A0A087WXS7;O43681;K7ERW9 ATPase ASNA1 ASNA1 P31939;F5GWY2;P ;H7C1S2 Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxami de formyltransferase;imp cyclohydrolase ATIC Q6DD88;F5H6I7;C9JUU1 Atlastin-3 ATL3 P ;P ;P05023;P ;M0R116;P13637;P ;P ;A0A0A0MT26 Sodium/potassium-transporting ATPase subunit alpha-1;sodium/potassium-transporting ATPase subunit alpha-3 ATP1A1;ATP1A3 P16615;P ;P ;P ;H7C5W9;P Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Q ;Q ;Q ;Q ;Q93084;Q ;Q Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 ATP2A3 P25705;P ;K7ENP3;K7EK77 ATP synthase subunit alpha, ;ATP synthase subunit alpha ATP5A1 P06576;H0YH81;F8VPV9;F8W079 ATP synthase subunit beta, ;ATP synthase subunit beta ATP5B P36542;B4DL14;P ATP synthase subunit gamma, ;ATP synthase subunit gamma ATP5C1 Q5QNZ2;P24539 ATP synthase subunit b, ATP5F1 O ;O75947;F5H608 ATP synthase subunit d, ATP5H S44

45 P ;P56134;P ;C9JJT5;P ;F5H4H2;C9JU26;G3V325 ATP synthase subunit f, ATP5J2;PTCD1;ATP5J2- PTCD1 P48047 ATP synthase subunit O, ATP5O B7Z1R5;P38606 V-type proton ATPase catalytic subunit A ATP6V1A Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3;H3BUF6;H3BSK9 Ataxin-2-like protein ATXN2L Q9Y679-3;Q9Y679-2;Q9Y679 Ancient ubiquitous protein 1 AUP1 C9JEV0;P25311 Zinc-alpha-2-glycoprotein AZGP1 O95817;C9JFK9 BAG family molecular chaperone regulator 3 BAG3 F6S6P2;P ;P ;P ;B0UX83;P46379;P Large proline-rich protein BAG6 BAG6 P51572;P ;C9JSP1;C9JQ75;C9J0M4 B-cell receptor-associated protein 31 BCAP31 P55957;P BH3-interacting domain death agonist;bh3- interacting domain death agonist p15;bh3- interacting domain death agonist p13;bh3- interacting domain death agonist p11 BID P53004 Biliverdin reductase A BLVRA P30043;M0QZL1;M0R192 Flavin reductase (NADPH) BLVRB Q8TDN6 Ribosome biogenesis protein BRX1 homolog BRIX1 B4DDM6;J3QT28;O ;O43684 Mitotic checkpoint protein BUB3 BUB3 Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80 Basic leucine zipper and W2 domain-containing protein 1 BZW1 G3V4C6;Q9Y224;H0YJB9 UPF0568 protein C14orf166 C14orf166 Q07021;I3L3Q7;I3L3B0 Complement component 1 Q subcomponentbinding protein, C1QBP P30042;H7C1F6;H7C2G3;P ES1 protein homolog, C21orf33 Q9Y3I0 trna-splicing ligase RtcB homolog C22orf28 Q9H993;F5GZY1 UPF0364 protein C6orf211 C6orf211 Q9BUH6 Uncharacterized protein C9orf142 C9orf142 P00918 Carbonic anhydrase 2 CA2 P62158;E7ETZ0;H0Y7A7;E7EMB3;F8WBR5;M0Q Z52;G3V479;G3V361;Q96HY3 Calmodulin CALM1;CALM2;CALM3 P27797;K7EJB9 Calreticulin CALR O ;O43852;O ;O ;H0Y875;O ;O ;O Calumenin CALU S45

46 Q86VP6;Q86VP6-2 Cullin-associated NEDD8-dissociated protein 1 CAND1 P27824;B4DGP8;B4E2T8 Calnexin CANX Q ;Q01518;Q5T0R8;Q5T0S3;Q5T0R7;Q5T0R6;Q5 T0R5;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R1;Q5T0R9 Adenylyl cyclase-associated protein 1 CAP1 P07384 Calpain-1 catalytic subunit CAPN1 U3KQE2;K7EIV0;P04632;U3KPR7;K7EKD8;K7EL J7;K7EM73 Calpain small subunit 1 CAPNS1 P52907 F-actin-capping protein subunit alpha-1 CAPZA1 P ;P47756;B1AK87;B1AK88;B1AK85;F6USW4 F-actin-capping protein subunit beta CAPZB Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Histone-arginine methyltransferase CARM1 CARM1 P31944 Caspase-14;Caspase-14 subunit p19;caspase- 14 subunit p10 CASP14 P04040 Catalase CAT B4DFK7;E9PQ63;A8MTM1;P16152 Carbonyl reductase [NADPH] 1 CBR1 B5MD17;J3KS05;P83916;C9JWS9;K7ELA4 Chromobox protein homolog 1 CBX1 Q13185;C9JMM0;B8ZZ43;S4R2Y4 Chromobox protein homolog 3 CBX3 P45973 Chromobox protein homolog 5 CBX5 Q96A33-2;Q96A33 Coiled-coil domain-containing protein 47 CCDC47 P78371;P ;F5GWF6;F8VQ14 T-complex protein 1 subunit beta CCT2 B4DUR8;P ;P49368 T-complex protein 1 subunit gamma CCT3 B7Z9L0;P50991;P ;B7Z2F4 T-complex protein 1 subunit delta CCT4 B7ZAR1;E9A1;P48643;B4DYD8;E7ENZ3 T-complex protein 1 subunit epsilon CCT5 B4DPJ8;P40227;P T-complex protein 1 subunit zeta CCT6A Q ;Q99832;F5GZK5;Q ;Q ;B7Z1C9 T-complex protein 1 subunit eta CCT7 P50990;B4DEM7;B4DQH4 T-complex protein 1 subunit theta CCT8 O95400 CD2 antigen cytoplasmic tail-binding protein 2 CD2BP2 Q16543;K7EQA9;K7EKQ2 Hsp90 co-chaperone Cdc37;Hsp90 cochaperone Cdc37, N-terminally processed CDC37 P60953;E7ETU3 Cell division control protein 42 homolog CDC42 O ;O14735;B3KY94 CDP-diacylglycerol--inositol 3- phosphatidyltransferase CDIPT Q15517;G8JLG2 Corneodesmosin CDSN Q9BXW7-2;Q9BXW7;A8MYZ9 Cat eye syndrome critical region protein 5 CECR5 Q96G23;Q5SZE1;H0YLQ6;Q5SZE6;H0YNU7 Ceramide synthase 2 CERS2 S46

47 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7 Cofilin-1 CFL1 Q9NX63;C9JRZ6;G3V1K1;F8WAR4 Coiled-coil-helix-coiled-coil-helix domaincontaining protein 3, CHCHD3 F5GWX5;Q14839;Q ;Q8TDI0 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5 CHD4;CHD5 Q07065 Cytoskeleton-associated protein 4 CKAP4 G3V4N7;P12277;G3V461 Creatine kinase B-type CKB P12532;F8WCN3;P ;C9JSQ1 Creatine kinase U-type, CKMT1A;CKMT1B O00299 Chloride intracellular channel protein 1 CLIC1 O95833;Q5SQ17 Chloride intracellular channel protein 3 CLIC3 Q9Y696 Chloride intracellular channel protein 4 CLIC4 Q ;O95086;H3BPM8;Q2TA70;B4DFF3;Q ;Q ;Q ;Q13286;O95090;Q9UBD8;H3BQ48;Q ;B4DMY6;Q Battenin CLN3 P ;P ;P ;P09496;F8WF69 Clathrin light chain A CLTA P ;P09497;H0Y9Q6 Clathrin light chain B CLTB Q ;Q00610 Clathrin heavy chain 1 CLTC Q8NFW8;Q8NFW8-2 N-acylneuraminate cytidylyltransferase CMAS Q96DG6 Carboxymethylenebutenolidase homolog CMBL P ;P62633;P ;P ;P ;P ;P ;P Cellular nucleic acid-binding protein CNBP P ;P21964;E7EMS6 Catechol O-methyltransferase COMT P53621;P Coatomer subunit alpha;xenin;proxenin COPA P53618;E9PP73 Coatomer subunit beta COPB1 B4DZI8;P35606 Coatomer subunit beta COPB2 Q9Y678 Coatomer subunit gamma-1 COPG1 Q9BR76;F5H390;E7EW44 Coronin-1B;Coronin CORO1B Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Coronin-1C;Coronin CORO1C O75131;E5RG68;E5RHZ0;H0YB26 Copine-3 CPNE3 G5E9W3;Q9UKF6 Cleavage and polyadenylation specificity factor subunit 3 CPSF3 C9J979;Q5TA45-2;Q5TA45-3;Q5TA45;Q96HV7;C9IYS7;A0A087WYI0;Q5TA45-4;Q5TA45-5 Integrator complex subunit 11 CPSF3L Q ;F8WJN3;Q16630;Q Cleavage and polyadenylation specificity factor subunit 6 CPSF6 S47

48 P ;P50416 Carnitine O-palmitoyltransferase 1, liver isoform CPT1A P29373;Q5SYZ4 Cellular retinoic acid-binding protein 2 CRABP2 H0YFA4;P52943;P ;H0YHD8 Cysteine-rich protein 2 CRIP2 P46109 Crk-like protein CRKL B4DJV2;O75390;H0YIC4 Citrate synthase;citrate synthase, CS O ;O75534;O ;G5E9Q2;E9PLT0 Cold shock domain-containing protein E1 CSDE1 P ;P ;P55060;B4DUC5 Exportin-2 CSE1L P41240 Tyrosine-protein kinase CSK CSK Q71TU5;P48729;E5RG27;D6RGE5;Q8N752;P Casein kinase I isoform alpha;casein kinase I isoform alpha-like CSNK1A1;CSNK1A1L P21291;E9PS42;E9PND2;E9PP21 Cysteine and glycine-rich protein 1 CSRP1 P04080 Cystatin-B CSTB E9PID8;P ;P33240;E7EWR4 Cleavage stimulation factor subunit 2 CSTF2 P56545;Q5SQP8;P C-terminal-binding protein 2 CTBP2 P35221;P ;G3XAM7;F8W845;P Catenin alpha-1 CTNNA1 B4DGU4;P35222 Catenin beta-1 CTNNB1 P17812;B7Z9C4 CTP synthase 1 CTPS1 P10619 Lysosomal protective protein;lysosomal protective protein 32 kda chain;lysosomal protective protein 20 kda chain CTSA P07858;R4GMQ5 Cathepsin B;Cathepsin B light chain;cathepsin B heavy chain CTSB P07339;H7C469;H7C1V0;F8WD96;C9JH19 Cathepsin D;Cathepsin D light chain;cathepsin D heavy chain CTSD Q14247 Src substrate cortactin CTTN D6RFH4;H3BUX2;O43169;J3KNF8 Cytochrome b5 type B CYB5B B1AHF3;P ;P00387;P NADH-cytochrome b5 reductase 3;NADHcytochrome b5 reductase 3 membrane-bound form;nadh-cytochrome b5 reductase 3 soluble form CYB5R3 P08574 Cytochrome c1, heme protein, CYC1 Q7L576;E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2 Cytoplasmic FMR1-interacting protein 1;Cytoplasmic FMR1-interacting protein 2 CYFIP1;CYFIP2 F5GXX5;P61803;F5H895 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 DAD1 S48

49 P14868;P ;C9J7S3;C9JLC1 Aspartate--tRNA ligase, cytoplasmic DARS P14868;Q68CR9 Aspartate--tRNA ligase, cytoplasmic DARS;DKFZp781B11202 Q6PI48 Aspartate--tRNA ligase, DARS2 K7EQ02;Q96EP5-2;K7EQ55;K7EK33;Q96EP5 DAZ-associated protein 1 DAZAP1 B4DDD6;Q9UJU6;Q9UJU6-2;Q9UJU6-3;B4DEM2;C9J7P1;H0Y5J4;B4DDP6 Drebrin-like protein DBNL P61962;E9Y4 DDB1- and CUL4-associated factor 7 DCAF7 D6RCP9;P27707;D6RFG8 Deoxycytidine kinase DCK Q9UJW0;Q9UJW0-3;Q9UJW0-2 Dynactin subunit 4 DCTN4 J3KS22;J3QS36;Q7Z4W1;J3QS45;J3KRZ4;J3KSZ 5;J3QL34 L-xylulose reductase DCXR Q16531;F5GY55 DNA damage-binding protein 1 DDB1 Q92466;Q ;Q DNA damage-binding protein 2 DDB2 P39656;E7EWT1;U3KQ84 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit DDOST P30046;J3KQ18;B7Z522;A6NHG4;B5MC82 D-dopachrome decarboxylase;d-dopachrome decarboxylase-like protein DDT;DDTL Q92499 ATP-dependent RNA helicase DDX1 DDX1 Q ;Q ;Q92841;H3BLZ8;Q ;C9JMU5 Probable ATP-dependent RNA helicase DDX17 DDX17 Q9NVP1 ATP-dependent RNA helicase DDX18 DDX18 Q9NR30-2;Q9NR30 Nucleolar RNA helicase 2 DDX21 Q9BUQ8 Probable ATP-dependent RNA helicase DDX23 DDX23 O00148;O ;K7EQN7;B1Q2N1 ATP-dependent RNA helicase DDX39A DDX39A;DDX39 Q13838;Q ;F8VQ10;Q5STU3;B4DP52;F6WLT2;F6S4E6;F6 UN21;F6TRA5;F6UJC5 Spliceosome RNA helicase DDX39B DDX39B O ;O00571;B4DXX7;O15523 ATP-dependent RNA helicase DDX3X;ATPdependent RNA helicase DDX3Y DDX3X;DDX3Y B4DLW8;P17844;J3KTA4 Probable ATP-dependent RNA helicase DDX5 DDX5 Q8TDD1;Q8TDD1-2;F8VRX4 ATP-dependent RNA helicase DDX54 DDX54 P26196 Probable ATP-dependent RNA helicase DDX6 DDX6 B7Z6B8;Q16698;E5RJG7;E5RFV2 2,4-dienoyl-CoA reductase, DECR1 Q4VXZ8;Q9NUI1;Q9NUI1-3 Peroxisomal 2,4-dienoyl-CoA reductase DECR2 S49

50 P ;B4DFG0;P35659;D6RDA2 Protein DEK DEK E5RGY0;B4E1G1;Q9BUN8-2;Q9BUN8 Derlin-1 DERL1 B7Z817;Q15392 Delta(24)-sterol reductase DHCR24 Q9UBM7;E9PM00 7-dehydrocholesterol reductase DHCR7 Q9BTZ2-8;Q9BTZ2-4;Q9BTZ2 H7C1J3;Q96HY7 Dehydrogenase/reductase SDR family member 4 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, DHRS4 DHTKD1 O43143 Putative pre-mrna-splicing factor ATPdependent RNA helicase DHX15 DHX15 Q08211 ATP-dependent RNA helicase A DHX9 O ;O60832;H7C0M1;C9IYT0;H7C2Q9 H/ACA ribonucleoprotein complex subunit 4 DKC1 H0YDD4;P10515;F5H7M3;E9PEJ4 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, DLAT B4DHG0;B4DT69;E9PEX6;P09622 Dihydrolipoyl dehydrogenase;dihydrolipoyl dehydrogenase, DLD P36957;B7Z5W8 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, DLST Q9ULA0;E7ETB3;E7EMB6;B9ZVU2;F8WAN0;E7E PX3;C9JBE1 Aspartyl aminopeptidase DNPEP Q9P2X0;Q9P2X0-2 Dolichol-phosphate mannosyltransferase subunit 3 DPM3 Q9NY33-4;Q9NY33;G3V1D3;G3V180;E9PQ14 Dipeptidyl peptidase 3 DPP3 Q ;Q16555 Dihydropyrimidinase-related protein 2 DPYSL2 P15924;P Desmoplakin DSP P60981;P ;F6RFD5 Destrin DSTN P ;H0YNW5;H0YKC5;P33316;H0YMP1;H0YMM5;H 0YNJ9;H0YKI0 Deoxyuridine 5-triphosphate nucleotidohydrolase, DUT Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 P63167;F8VXL2;F8VRV5;Q96FJ2 Dynein light chain 1, cytoplasmic;dynein light chain 2, cytoplasmic DYNLL1;DYNLL2 Q15125;C9J719;C9JJ78 3-beta-hydroxysteroid-Delta(8),Delta(7)- isomerase EBP S50

51 Q13011;M0R248 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, ECH1 P30084 Enoyl-CoA hydratase, ECHS1 P ;P42126;H3BS70;Q96DC0 Enoyl-CoA delta isomerase 1, ECI1;DCI Q5VTE0;P68104 Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EEF1A1P5;EEF1A1 Q05639 Elongation factor 1-alpha 2 EEF1A2 P24534;F8WF65;F2Z2G2;C9JZW3 Elongation factor 1-beta EEF1B2 E9PK01;P29692;P ;E9PRY8;P ;E9PPR1;E9PL12;E9PQ49;E9PI39;E9PMW7;E9 PIZ1;E9PL71;H0YCK7;E9PQZ1;P Elongation factor 1-delta EEF1D P26641;B4DTG2 Elongation factor 1-gamma EEF1G P13639 Elongation factor 2 EEF2 Q96C19 EF-hand domain-containing protein D2 EFHD2 Q ;Q15029;K7EJ kda U5 small nuclear ribonucleoprotein component EFTUD2 P05198;H0YJS4;G3V4T5 Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 P41091;Q2VIR3;Q2VIR3-2;F8W810 Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein EIF2S3;EIF2S3L F5H335;Q14152 Eukaryotic translation initiation factor 3 subunit A EIF3A P55884;P ;C9JQN7 Eukaryotic translation initiation factor 3 subunit B EIF3B H3BRV0;Q99613;B5ME19 Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein EIF3C;EIF3CL B4DVY1;O15371 Eukaryotic translation initiation factor 3 subunit D EIF3D E5RHS5;E5RGA2;P60228;H0YAW4 Eukaryotic translation initiation factor 3 subunit E EIF3E B0QY90;Q9Y262-2;Q9Y262;B0QY89 Eukaryotic translation initiation factor 3 subunit L EIF3L P60842;J3KT12;P ;J3KTB5;J3QS69;J3QR64;J3KSZ0;J3QL43 Eukaryotic initiation factor 4A-I EIF4A1 P60842;J3KTB5;J3KT12;P ;J3QS69;J3QR64;J3QL43;J3QLN6;J3KS25;J3QK Z9;E7EQG2;Q14240;Q Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II EIF4A1;EIF4A2 P38919 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed EIF4A3 S51

52 Q ;Q ;Q ;E7EX73;Q ;E9PGM1;Q ;E7EUU4;Q04637;Q ;Q Eukaryotic translation initiation factor 4 gamma 1 EIF4G1 I3L397;P63241;P ;I3L504;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6I S14 Eukaryotic translation initiation factor 5A- 1;Eukaryotic translation initiation factor 5A- 2;Eukaryotic translation initiation factor 5A-1-like EIF5A;EIF5A2;EIF5AL1 P56537;B7ZBH1 Eukaryotic translation initiation factor 6 EIF6 Q9BQ52-4;G5E9D5;Q9BQ52;Q9BQ52-2;E7ES68 Zinc phosphodiesterase ELAC protein 2 ELAC2 Q15717;B4DVB8;M0QZR9 ELAV-like protein 1 ELAVL1 P50402;Q5HY57 Emerin EMD P06733;P Alpha-enolase ENO1 P58107;E9PPU0 Epiplakin EPPK1 P07814;V9GYZ6 Bifunctional glutamate/proline--trna ligase;glutamate--trna ligase;proline--trna ligase EPRS Q9H6S3;B7ZKL3 Epidermal growth factor receptor kinase substrate 8-like protein 2 EPS8L2 Q969X5-2;Q969X5 Endoplasmic reticulum-golgi intermediate compartment protein 1 ERGIC1 G3V279;P84090 Enhancer of rudimentary homolog ERH B0QZ43;E5RHW4;O94905;O75477;O ;O Erlin-2;Erlin-1 ERLIN1;ERLIN2 Q7Z2K6;E7ER77 Endoplasmic reticulum metallopeptidase 1 ERMP1 Q96HE7 ERO1-like protein alpha ERO1L P30040;F8VY02 Endoplasmic reticulum resident protein 29 ERP29 Q9BS26 Endoplasmic reticulum resident protein 44 ERP44 P10768;H7BZT7 S-formylglutathione hydrolase ESD H0YBR2;H0YBB3;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1;E5RI26 Epithelial splicing regulatory protein 1 ESRP1 Q9H6T0-2;Q9H6T0;H0YBR2;H0YBB3;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 Epithelial splicing regulatory protein 2;Epithelial splicing regulatory protein 1 ESRP2;ESRP1 Q9BSJ8;Q9BSJ8-2 Extended synaptotagmin-1 ESYT1 H7BXI1;A0FGR8-6;A0FGR8-2;A0FGR8 Extended synaptotagmin-2 ESYT2 P13804;P ;H0YLU7;H0YL12;H0YK49;H0YNX6;H0YKF0 Electron transfer flavoprotein subunit alpha, ETFA P38117;P Electron transfer flavoprotein subunit beta ETFB S52

53 O95571;M0QXB5 Persulfide dioxygenase ETHE1, ETHE1 H7BY36;Q ;C9JGE3;Q ;B0QYK0;Q ;Q01844;Q RNA-binding protein EWS EWSR1 Q5RKV6 Exosome complex component MTR3 EXOSC6 P15311;E7EQR4 Ezrin EZR Q96CS3 FAS-associated factor 2 FAF2 Q9NZB2-4;Q9NZB2;Q9NZB2-6 Constitutive coactivator of PPAR-gamma-like protein 1 FAM120A Q96TA1-2;Q96TA1 Niban-like protein 1 FAM129B Q52LJ0;Q52LJ0-2 Protein FAM98B FAM98B Q9NSD9;F5H6Y1 Phenylalanine--tRNA ligase beta subunit FARSB P49327 Fatty acid synthase;[acyl-carrier-protein] S- acetyltransferase;[acyl-carrier-protein] S- malonyltransferase;3-oxoacyl-[acyl-carrierprotein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;enoyl-[acyl-carrier-protein] reductase;oleoyl-[acyl-carrier-protein] hydrolase FASN P22087;M0R0P1;M0R299;M0QXL5;M0R2Q4;M0R 2U2;M0R1H0;M0R2B0 rrna 2-O-methyltransferase fibrillarin FBL P09467 Fructose-1,6-bisphosphatase 1 FBP1 Q8NEZ5-3;Q8NEZ5;H3BTH6 F-box only protein 22 FBXO22 P ;P14324 Farnesyl pyrophosphate synthase FDPS P39748;I3L3E9;F5H1Y3;P Flap endonuclease 1 FEN1 P ;P07954 Fumarate hydratase, FH Q00688 Peptidyl-prolyl cis-trans isomerase FKBP3 FKBP3 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed FKBP4 Q14318;Q ;J3KQ73;Q Peptidyl-prolyl cis-trans isomerase FKBP8 FKBP8 P ;P21333;Q5HY54 Filamin-A FLNA O ;O ;O75369;O ;O ;O ;E7EN95;O ;O ;O Filamin-B FLNB I3L4I0;Q96CP2;I3L1Y9 FLYWCH family member 2 FLYWCH2 P02794;G3V192;G3V1D1 Ferritin heavy chain;ferritin FTH1 P02792 Ferritin light chain FTL S53

54 Q8IY81 pre-rrna processing protein FTSJ3 FTSJ3 Q96AE4;Q96AE4-2;E9PEB5;B4DT31 Far upstream element-binding protein 1 FUBP1 Q96I24 Far upstream element-binding protein 3 FUBP3 P ;P35637;H3BPE7 RNA-binding protein FUS FUS P ;B4DXZ6;P51114;C9JAJ4;E7EU85;E9PFF5;P ;R9WNI0;A8MQB8;Q ;Q ;G3V0J0;Q ;Q ;Q ;Q ;Q ;Q ;Q06787;P51116 Fragile X mental retardation syndrome-related protein 1;Fragile X mental retardation protein 1;Fragile X mental retardation syndrome-related protein 2 FXR1;FMR1;FXR2 E7EUI8;E7EM57 Glucose-6-phosphate 1-dehydrogenase G6PD P10253 GAA P51570;B4E1G6 Galactokinase GALK1 Q14697;Q ;F5H6X6;E9PKU7 Neutral alpha-glucosidase AB GANAB P04406;P ;E7EUT5 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Lysosomal alpha-glucosidase;76 kda lysosomal alpha-glucosidase;70 kda lysosomal alphaglucosidase F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;B0QZ65;B4DGD8;C9IZ08 GTPase-activating protein and VPS9 domaincontaining protein 1 GAPVD1 P41250 Glycine--tRNA ligase GARS P22102;P ;C9JBJ1;C9JTV6;F8WD69 Trifunctional purine biosynthetic protein adenosine-3;phosphoribosylamine--glycine ligase;phosphoribosylformylglycinamidine cycloligase;phosphoribosylglycinamide formyltransferase GART P48506 Glutamate--cysteine ligase catalytic subunit GCLC Q92616 Translational activator GCN1 GCN1L1 P31150 Rab GDP dissociation inhibitor alpha GDI1 P50395;E7EU23;P ;Q5SX87 Rab GDP dissociation inhibitor beta GDI2 Q7L5L3-1;Q7L5L3 Glycerophosphodiester phosphodiesterase domain-containing protein 3 GDPD3 Q7L5D6;C9JPA8;C9JY46;C9JHN8;Q7L5D6-2 Golgi to ER traffic protein 4 homolog GET4 F8WAU4;C9IZ01;Q96RP9;Q96RP9-2 Elongation factor G, GFM1 S54

55 Q ;Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 GFPT1 P ;B7Z856;P56159 GDNF family receptor alpha-1 GFRA1 M0QZK8;O75223;O Gamma-glutamylcyclotransferase GGCT Q92820 Gamma-glutamyl hydrolase GGH P ;E7EQ29;P ;P16278 Beta-galactosidase GLB1 Q04760;Q Lactoylglutathione lyase GLO1 B7Z403;Q9HC38-2;Q9HC38;I3L1I0;Q9HC38-3;I3L3Q4 Glyoxalase domain-containing protein 4 GLOD4 O ;O94925;H7BZD1;O Glutaminase kidney isoform, GLS P00367;B4DGN5;B3KV55;P49448 Glutamate dehydrogenase 1, ;Glutamate dehydrogenase;glutamate dehydrogenase 2, GLUD1;GLUD2 F8W720;P49915 GMP synthase [glutamine-hydrolyzing] GMPS Q14344;F5H1G8 P04899;P ;B4E2X5;P ;P ;B3KTZ0;F5GZL8 Guanine nucleotide-binding protein subunit alpha-13 Guanine nucleotide-binding protein G(i) subunit alpha-2 GNA13 GNAI2 P04899;P ;P ;P ;P ;P ;P63096 Guanine nucleotide-binding protein G(i) subunit alpha-2;guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI2;GNAI1 P08754 P63092;P ;Q5JWF2;P ;P ;Q5JWF2-2 Guanine nucleotide-binding protein G(k) subunit alpha Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAI3 GNAS P62873;F6UT28;B1AKQ8;F6X3N5 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 C9JIS1;C9JXA5;P62879;C9JZN1;E7EP32;Q9HAV 0 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;guanine nucleotide-binding protein subunit beta-4 GNB2;GNB4 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;H0Y AM7;D6REE5;D6RHH4;D6R9Z1;D6R9L0;D6RFX4 Guanine nucleotide-binding protein subunit beta- 2-like 1 GNB2L1 P00505;E7ERW2 Aspartate aminotransferase, ;Aspartate aminotransferase GOT2 Q8N335;C9JFA7 Glycerol-3-phosphate dehydrogenase 1-like protein GPD1L S55

56 P43304;P ;F8W6E4 Glycerol-3-phosphate dehydrogenase, GPD2 P06744;P ;K7EQ48 Glucose-6-phosphate isomerase GPI P ;P62993 Growth factor receptor-bound protein 2 GRB2 Q9UBQ7;U3KQ56;Q5T946 Glyoxylate reductase/hydroxypyruvate reductase GRHPR P ;P ;P15170;H3BR35 Eukaryotic peptide chain release factor GTPbinding subunit ERF3A GSPT1 P ;P ;P15170;H3BR35;Q8IYD1 Eukaryotic peptide chain release factor GTPbinding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B GSPT1;GSPT2 P ;P ;P00390;P ;P Glutathione reductase, GSR Q9Y2Q3-4;E9PFN5;Q9Y2Q3;Q9Y2Q3-3;Q9Y2Q3-2 Glutathione S-transferase kappa 1 GSTK1 P21266 Glutathione S-transferase Mu 3 GSTM3 P78417;Q5TA02;P ;P ;Q5TA01 Glutathione S-transferase omega-1 GSTO1 P ;P ;P ;P78347 General transcription factor II-I GTF2I Q9BZE4-2;Q9BZE4;Q9BZE4-3 Nucleolar GTP-binding protein 1 GTPBP4 P ;P07305 Histone H1.0;Histone H1.0, N-terminally processed Q92522 Histone H1x H1FX Q71UI9;P0C0S5;Q71UI9-4;Q71UI9-2;C9J0D1;Q71UI9-3 Histone H2A.V;Histone H2A.Z;Histone H2A H1F0 H2AFV;H2AFZ O ;O ;O75367;D6RCF2;B4DJC3 Core histone macro-h2a.1;histone H2A H2AFY K7EMV3;B4DEB1;K7EK07;Q71DI3;Q16695;P8424 3;P68431;K7ES00;K7EP01;Q6NXT2 Histone H3;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1;Histone H3.3C H3F3B;H3F3A;HIST2H3A;H IST3H3;HIST1H3A;H3F3C K7EK07;Q71DI3;Q16695;P84243;P68431;K7EMV 3;B4DEB1;K7ES00;Q6NXT2 Histone H3;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1;Histone H3.3C H3F3B;HIST2H3A;HIST3H3 ;H3F3A;HIST1H3A;H3F3C Q16836;E9PF18;Q ;Q Hydroxyacyl-coenzyme A dehydrogenase, HADH P40939 Trifunctional enzyme subunit alpha, ;Long-chain enoyl-coa hydratase;long chain 3-hydroxyacyl-CoA dehydrogenase HADHA B4E2W0;P55084;B5MD38;F5GZQ3;C9JEY0;C9JE 81 Trifunctional enzyme subunit beta, ;3-ketoacyl-CoA thiolase HADHB O14929;O Histone acetyltransferase type B catalytic subunit HAT1 S56

57 P ;P51610;P ;A6NEM2 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 HCFC1 Q13547;F5GXM1 Histone deacetylase 1 HDAC1 P51858;A8K8G0;P ;P Hepatoma-derived growth factor HDGF Q9BSH5 Haloacid dehalogenase-like hydrolase domaincontaining protein 3 HDHD3 Q00341;Q ;H0Y394 Vigilin HDLBP Q6AI08;A0A087WXZ7;K7EIX2 HEAT repeat-containing protein 6 HEATR6 P hydroxyisobutyrate dehydrogenase, HIBADH P16401 Histone H1.5 HIST1H1B P10412;P16403;P16402;Q02539 Histone H1.4;Histone H1.2;Histone H1.3;Histone H1.1 HIST1H1E;HIST1H1C;HIST 1H1D;HIST1H1A Q99880;Q99879;Q99877;Q93079;Q5QNW6;P628 07;P58876;P57053;O60814;Q5QNW6-2;U3KQK0;B4DR52 Histone H2B type 1-L;Histone H2B type 1- M;Histone H2B type 1-N;Histone H2B type 1- H;Histone H2B type 2-F;Histone H2B type 1- C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B HIST1H2BL;HIST1H2BM;HI ST1H2BN;HIST1H2BH;HIS T2H2BF;HIST1H2BC;HIST1 H2BD;H2BFS;HIST1H2BK Q99880;Q99879;Q99877;Q93079;Q5QNW6;P628 07;P58876;O60814;Q5QNW6-2;U3KQK0;P57053 Histone H2B type 1-L;Histone H2B type 1- M;Histone H2B type 1-N;Histone H2B type 1- H;Histone H2B type 2-F;Histone H2B type 1- C/E/F/G/I;Histone H2B type 1-D;Histone H2B type 1-K;Histone H2B type F-S HIST1H2BL;HIST1H2BM;HI ST1H2BN;HIST1H2BH;HIS T2H2BF;HIST1H2BC;HIST1 H2BD;HIST1H2BK;H2BFS P62805 Histone H4 HIST1H4A Q16777;Q6FI13;Q99878;Q96KK5;Q9BTM1;P0C0 S8;P20671;Q9BTM1-2;H0YFX9;Q93077;Q7L7L0;P04908;Q96QV6 Histone H2A type 2-C;Histone H2A type 2- A;Histone H2A type 1-J;Histone H2A type 1- H;Histone H2A.J;Histone H2A type 1;Histone H2A type 1-D;Histone H2A;Histone H2A type 1- C;Histone H2A type 3;Histone H2A type 1- B/E;Histone H2A type 1-A HIST2H2AC;HIST2H2AA3;H IST1H2AJ;HIST1H2AH;H2A FJ;HIST1H2AG;HIST1H2AD ;HIST1H2AC;HIST3H2A;HIS T1H2AB;HIST1H2AA S57

58 Q16778;P33778;P23527;P06899;Q8N257;Q96A08 Histone H2B type 2-E;Histone H2B type 1- B;Histone H2B type 1-O;Histone H2B type 1- J;Histone H2B type 3-B;Histone H2B type 1-A HIST2H2BE;HIST1H2BB;HI ST1H2BO;HIST1H2BJ;HIST 3H2BB;HIST1H2BA Q5TEC6 0 HIST2H3PS2 P ;P ;P19367;P ;E7ENR4 Hexokinase-1 HK1 Q8TCT9-5;Q8TCT9;Q8TCT9-4;Q8TCT9-2 Minor histocompatibility antigen H13 HM13 Q5T7C4;Q5T7C6;P09429;Q5T7C0 High mobility group protein B1 HMGB1 P26583;D6R9A6 High mobility group protein B2 HMGB2 B1AK13;P35914 Hydroxymethylglutaryl-CoA lyase, HMGCL P ;P30519;A0A087WT44;I3L1Y2;I3L159;I3L1F5 Heme oxygenase 2 HMOX2 H3BMT0;H3BTV5;H3BU16;Q9H910-2;A6NGP5;Q9H910;H3BMV3;B4DLH4 Hematological and neurological expressed 1-like protein HN1L Q13151 Heterogeneous nuclear ribonucleoprotein A0 HNRNPA0 P ;F8W6I7;P ;P09651;F8VZ49;F8VTQ5;Q32P51;F8W646 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1- like 2 HNRNPA1;HNRNPA1L2 P22626;P Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 D6R9P3;D6RD18;Q ;D6RBZ0;Q ;Q ;Q99729 Heterogeneous nuclear ribonucleoprotein A/B HNRNPAB G3V4W0;B4DY08;B2R5W2;G3V4C1;P ;G3V576;P ;G3V2Q1;P07910;G3V555;G3V575;G3V5X6;G3V 3K6;G3V251;B4DSU6 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRN G3V576;P ;G3V4W0;B4DY08;G3V4C1;P ;G3V2Q1;P07910;G3V555;G3V575;G3V5X6;G3V 3K6;G3V251;B4DSU6;G3V4M8;P ;O60812 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 1 HNRN;HNRNL1 H0Y8G5;Q ;Q14103;H0YA96;Q ;B4DTC3;Q ;D6RAF8;D6RF44;D6RBQ9 Heterogeneous nuclear ribonucleoprotein D0 HNRNPD P52597 Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed HNRNPF S58

59 P31943;G8JLB6;E9Y7;D6RBM0;D6RIT2;D6RI U0;E7EQJ0;D6RAM1;E5RGV0;D6R9T0;D6RFM3; E7EN40;D6RDU3;D6RJ04;D6RIH9;H0YB39 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed HNRNPH1 P55795 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed HNRNPH2 P ;P ;P31942;P ;P ;P ;B4DHY1 Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 P61978;P ;Q5T6W1 Heterogeneous nuclear ribonucleoprotein K HNRNPK P14866;P ;M0QXS5 Heterogeneous nuclear ribonucleoprotein L HNRNPL Q8WVV9-5;B7WPG3;Q8WVV9-4;C9IYN3;Q8WVV9;D6W592;H7C464 Heterogeneous nuclear ribonucleoprotein L-like HNRNPLL;HNRPLL P ;P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM O43390;O ;O ;B4DT28;S4R3J4;E7ETM7 Heterogeneous nuclear ribonucleoprotein R HNRNPR;HNRPR Q ;Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU Q9BUJ2-4;B7Z4B8;Q9BUJ2-2;Q9BUJ2;M0R3F1;Q9BUJ2-3;M0QYZ0 Heterogeneous nuclear ribonucleoprotein U-like protein 1 HNRNPUL1 Q1KMD3;H3BQZ7 Heterogeneous nuclear ribonucleoprotein U-like protein 2 HNRNPUL2;hCG_ O ;O ;O14979 Heterogeneous nuclear ribonucleoprotein D-like HNRPDL Q5JB52;B7WPG3;Q8WVV9-4;Q8WVV9;D6W592 Heterogeneous nuclear ribonucleoprotein L-like HNRPLL;HNRNPLL B0QZK4;Q5SWC8;X6RGJ2;Q5SSJ5-2;Q5SSJ5;Q5SSJ5-3 Heterochromatin protein 1-binding protein 3 HP1BP3 P00492 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 Q99714;Q ;Q5H928 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 P51659;E7EWE5;P ;P ;E7ER27;G5E9S2;E7ET17 Peroxisomal multifunctional enzyme type 2;(3R)- hydroxyacyl-coa dehydrogenase;enoyl-coa hydratase 2 HSD17B4 Q3SXM5;Q3SXM5-2 Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL1 Q6YN16;Q6YN16-2 Hydroxysteroid dehydrogenase-like protein 2 HSDL2 P07900;P ;Q86U12 Heat shock protein HSP 90-alpha HSP90AA1 P08238 Heat shock protein HSP 90-beta HSP90AB1 P14625 Endoplasmin HSP90B1 P08107;P ;E7EP94;V9GZ37 Heat shock 70 kda protein 1A/1B HSPA1A P34932 Heat shock 70 kda protein 4 HSPA4 S59

60 P kda glucose-regulated protein HSPA5 P11142;E9PKE3;P ;E9PN89;E9PNE6 Heat shock cognate 71 kda protein HSPA8 P38646 Stress-70 protein, HSPA9 P04792 Heat shock protein beta-1 HSPB1 P kda heat shock protein, HSPD1 B8ZZL8;P61604;S4R3N1 10 kda heat shock protein, HSPE1 Q ;Q ;Q92598;B4DYH1;B4DY72 Heat shock protein 105 kda HSPH1 O43719;Q5H919;Q5H918 HIV Tat-specific factor 1 HTATSF1 E9PL22;Q9Y4L1;B7Z909;E9PJ21 Hypoxia up-regulated protein 1 HYOU1 P41252;J3KR24 Isoleucine--tRNA ligase, cytoplasmic IARS F6SBX2;Q9NSE4 Isoleucine--tRNA ligase, IARS2 P14735;P Insulin-degrading enzyme IDE O75874;C9J4N6 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 P48735;B4DFL2;B4DSZ6 Isocitrate dehydrogenase [NADP], ;Isocitrate dehydrogenase [NADP] IDH2 P ;P50213;H0YMU3;B7Z9J8;H0YL72;H0YLI6 Isocitrate dehydrogenase [NAD] subunit alpha, IDH3A O ;O43837;O Isocitrate dehydrogenase [NAD] subunit beta, IDH3B Q12905 Interleukin enhancer-binding factor 2 ILF2 Q ;Q ;Q ;Q12906;Q ;Q ;Q Interleukin enhancer-binding factor 3 ILF3 M0R026;A1L0T0;M0R1B5;E9PJS0 Acetolactate synthase-like protein ILVBL H7C463;C9J406;B9A067;Q ;Q ;Q ;Q16891 Mitochondrial inner membrane protein IMMT H0Y4R1;P12268;E7ETK5 Inosine-5-monophosphate dehydrogenase 2 IMPDH2 Q27J81-2;Q27J81 Inverted formin-2 INF2 Q8TEX9;Q8TEX9-2;H0YN14;H0YN07;H0YMR4 Importin-4 IPO4 P46940;H0YLE8 Ras GTPase-activating-like protein IQGAP1 IQGAP1 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL Q96CN7 Isochorismatase domain-containing protein 1 ISOC1 Q96AB3;Q96AB3-2;Q96AB3-3;K7EKW4;K7ENV7 Isochorismatase domain-containing protein 2, ISOC2 P ;P26440;A0A0A0MT83;H0YKV0;H0YLC3;H7C4G 6 Isovaleryl-CoA dehydrogenase, IVD S60

61 P14923 Junction plakoglobin JUP Q15046;Q Lysine--tRNA ligase KARS O60341;O ;F6S0T5 Lysine-specific histone demethylase 1A KDM1A Q07666;Q ;Q KH domain-containing, RNA-binding, signal transduction-associated protein 1 KHDRBS1 Q92945;M0R0I5 Far upstream element-binding protein 2 KHSRP A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3;A0MZ66-7;A0MZ66-2 Shootin-1 KIAA1598 Q8N163-2;Q8N163 DBIRD complex subunit KIAA1967 KIAA1967 G5E9S8;Q ;G3V2E7;Q ;Q ;Q07866;F8W6L3;Q ;G3V3H3;Q ;Q ;Q ;G3V5R9;Q ;Q ;E7EVH7 Kinesin light chain 1 KLC1 P52292 Importin subunit alpha-1 KPNA2 Q14974;J3QR48;B7ZAV6 Importin subunit beta-1 KPNB1 P05783;F8VZY9 Keratin, type I cytoskeletal 18 KRT18 Q9H9P8-2;C9JVN9;Q9H9P8;G3V5S1;G3V272 L-2-hydroxyglutarate dehydrogenase, L2HGDH P ;P28838 Cytosol aminopeptidase LAP3 Q6PKG0-3;Q6PKG0;E5RH50 La-related protein 1 LARP1 P00338;P ;P ;P ;P ;F5GXY2 L-lactate dehydrogenase A chain LDHA P09382 Galectin-1 LGALS1 P17931;G3V3R6 Galectin-3 LGALS3 Q08380 Galectin-3-binding protein LGALS3BP Q6P1M3-2;J3QRV5;Q6P1M3 Lethal(2) giant larvae protein homolog 2 LLGL2 Q12907;D6RBV2;D6RIU4;D6RDX1 Vesicular integral-membrane protein VIP36 LMAN2 P02545;P ;P ;P Prelamin-A/C;Lamin-A/C LMNA P02545;P ;P ;P Prelamin-A/C;Lamin-A/C LMNA E9PBF6;P20700 Lamin-B1 LMNB1 P ;K7EJE8;K7EKE6;P ;P36776;K7ER27 Lon protease homolog, LONP1 Q8NF37 Lysophosphatidylcholine acyltransferase 1 LAT1 P42704 Leucine-rich PPR motif-containing protein, LRPPRC Q8N1G4 Leucine-rich repeat-containing protein 47 LRRC47 Q96AG4 Leucine-rich repeat-containing protein 59 LRRC59 S61

62 Q32MZ4-3;Q32MZ4-2;Q32MZ4 Leucine-rich repeat flightless-interacting protein 1 LRRFIP1 P48449;P ;P Lanosterol synthase LSS Q9Y383-3;Q9Y383-2;Q9Y383;Q96HJ9-2;B8ZZ10;A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29 Putative RNA-binding protein Luc7-like 2;Putative RNA-binding protein Luc7-like 1 LUC7L2;LUC7L O ;O75608;E5RGR0 Acyl-protein thioesterase 1 LYPLA1 Q9BQ69 O-acetyl-ADP-ribose deacetylase MACROD1 MACROD1 F5H6P7;P ;P61326;Q96A72 Protein mago nashi homolog;protein mago nashi homolog 2 MAGOHB;MAGOH Q ;Q02750 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 P36507 Dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 P ;P27816;E7EVA0;P ;B4DSQ1;H0Y2V1;F8W9U4;P ;E9PGM5 Microtubule-associated protein 4;Microtubuleassociated protein MAP4 P27361;E9PBK7;P ;E9PQW4;P ;E9PJF0;B3KR49 Mitogen-activated protein kinase 3 MAPK3 A0A087WZH7;P29966 Myristoylated alanine-rich C-kinase substrate MARCKS P49006 MARCKS-related protein MARCKSL1 P56192;B3KVK7;A6NC17 Methionine--tRNA ligase, cytoplasmic MARS B4DN45;P31153 S-adenosylmethionine synthase;sadenosylmethionine synthase isoform type-2 MAT2A P43243;A8MXP9;D6REM6;D6R991 Matrin-3 MATR3 Q7Z434;Q7Z434-4 Mitochondrial antiviral-signaling protein MAVS Q96N66-3;Q96N66;Q96N66-2 Lysophospholipid acyltransferase 7 MBOAT7 Q96RQ3;E9PHF7;E9PG35;G5E9X5;F5GYT8 Methylcrotonoyl-CoA carboxylase subunit alpha, MCCC1 Q9HCC0;Q9HCC0-2;D6RD67 Methylcrotonoyl-CoA carboxylase beta chain, MCCC2 P49736;H0Y8E6 DNA replication licensing factor MCM2 MCM2 P25205;B4DWW4;J3KQ69 DNA replication licensing factor MCM3 MCM3 P33991 DNA replication licensing factor MCM4 MCM4 B1AHB1;P33992 DNA replication licensing factor MCM5 MCM5 Q14566 DNA replication licensing factor MCM6 MCM6 P33993;P DNA replication licensing factor MCM7 MCM7 B9A041;P ;P40925;P ;B8ZZ51 Malate dehydrogenase, cytoplasmic MDH1 S62

63 P40926;E9PDB2;G3XAL0 Malate dehydrogenase, ;Malate dehydrogenase MDH2 P16455 P10620;F5GX73;F5H613;F5H7F6;F5H6X2;P ;F5H760 Methylated-DNA--protein-cysteine methyltransferase Microsomal glutathione S-transferase 1 MGMT MGST1 P14174 Macrophage migration inhibitory factor MIF Q ;Q13724;C9J8D4 Mannosyl-oligosaccharide glucosidase MOGS Q9Y676 28S ribosomal protein S18b, MRPS18B J3QLR8;Q9Y3D9 28S ribosomal protein S23, MRPS23 P ;P43246;E9PHA6 DNA mismatch repair protein Msh2 MSH2 Q9Y3D2;H0YE51 Methionine-R-sulfoxide reductase B2, MSRB2 O94776 Metastasis-associated protein MTA2 MTA2 Q9NZJ7-2;Q9NZJ7;Q5TDC2;H0Y8C3 Mitochondrial carrier homolog 1 MTCH1 E9PIE4 Mitochondrial carrier homolog 2 MTCH2 P11586;F5H2F4 C-1-tetrahydrofolate synthase, cytoplasmic;methylenetetrahydrofolate dehydrogenase;methenyltetrahydrofolate cyclohydrolase;formyltetrahydrofolate synthetase;c-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed MTHFD1 Q7Z406;Q7Z406-6;F2Z2U8;Q7Z406-2;G8JLL9;Q7Z406-5;Q7Z406-4;M0QY43 Myosin-14 MYH14 P35579;P Myosin-9 MYH9 P19105;O14950;J3QRS3 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B MYL12A;MYL12B F8W1R7;P ;P60660;J3KND3;G8JLA2;G3V1V0;B7Z6Z4;F8V PF3;G3V1Y7 Myosin light polypeptide 6 MYL6 O ;E9PDF6;O43795 Unconventional myosin-ib MYO1B O ;F5H6E2;O ;O00159 Unconventional myosin-ic MYO1C Q9UM54-5;Q9UM54-2;Q9UM54-6;Q9UM54-4;Q9UM54-1;E7EW20;Q9UM54 Unconventional myosin-vi MYO6 Q9NZM1-6;Q9NZM1-3;C9JCN0;Q9NZM1;F8W8J4;Q9NZM1-2;H0YD14;Q9NZM1-5 Myoferlin MYOF Q9UJ70;H7C3G9;Q9UJ70-2;C9JEV6;H7C286 N-acetyl-D-glucosamine kinase NAGK S63

64 Q9NR45 Sialic acid synthase NANS H0YHC3;F8W020;F8W118;F8VXI6;F8VUX1;F8VY 35;B3KV44;F8VV59;B7Z9C2;B3KNT8;F8W0J6;F5 H4R6;H0YIV4;P55209;H0YH88;F8W543;F8VRJ2 Nucleosome assembly protein 1-like 1 NAP1L1 M0R0Y2;P54920;M0R027;M0R058;M0R2M1 Alpha-soluble NSF attachment protein NAPA O43776;B4DN60 Asparagine--tRNA ligase, cytoplasmic NARS P ;P49321;P ;Q5T624;P ;H0YDS9;E9PRH9;H0YF33 Nuclear autoantigenic sperm protein NASP Q3LIE7;Q ;Q15392 Delta(24)-sterol reductase Nbla03646;DHCR24 Q09161 Nuclear cap-binding protein subunit 1 NCBP1 P19338;H7BY16 Nucleolin NCL O00483 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 P ;P ;P28331;P ;B4DJ81;P NADH-ubiquinone oxidoreductase 75 kda subunit, NDUFS1 P55769;B1AHD1 NHP2-like protein 1;NHP2-like protein 1, N- terminally processed NHP2L1 Q9BPW8;H7C2U6;C9JDV8 Protein NipSnap homolog 1 NIPSNAP1 Q9NQR4;H7C579 Omega-amidase NIT2 NIT2 Q96D46;C9JA08 60S ribosomal export protein NMD3 NMD3 P15531;P Nucleoside diphosphate kinase A NME1 P ;Q32Q12;P22392;J3KPD9;E7ERL0;E5RHP0 Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase NME2;NME1-NME2;NME1 Q15233;Q ;C9JYS8;C9IZL7;H7C367 Non-POU domain-containing octamer-binding protein NONO O00567;H0Y653;H0YDU4 Nucleolar protein 56 NOP56 Q9Y2X3 Nucleolar protein 58 NOP58 Q8NDH3;Q8NDH3-5;Q8NDH3-4;Q8NDH3-2;Q8NDH3-3 Probable aminopeptidase NPEPL1 NPEPL1 E9PLK3;P55786;B7Z463 Puromycin-sensitive aminopeptidase NPEPPS E9PLK3;P55786;P ;A6NEC2 Puromycin-sensitive aminopeptidase;puromycinsensitive aminopeptidase-like protein NPEPPS;NPEPPSL1 P ;P06748;P Nucleophosmin NPM1 B4DLR8;P ;P ;P15559;H3BNV2;H3BRK3 P24468;P ;P ;P10589 NAD(P)H dehydrogenase [quinone] 1 COUP transcription factor 2;COUP transcription factor 1 NQO1 NR2F2;NR2F1 S64

65 P01111;P ;P01116;P01112 GTPase NRas;GTPase KRas;GTPase KRas, N- terminally processed;gtpase HRas;GTPase HRas, N-terminally processed NRAS;KRAS;HRAS Q15738;C9JDR0 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL B4DFA2;I3L0N3;P46459 Vesicle-fusing ATPase NSF Q08J23-2;Q08J23;Q08J23-3 trna (cytosine(34)-c(5))-methyltransferase NSUN2 P49902;B7Z382 Cytosolic purine 5-nucleotidase NT5C2 Q5QPD0;Q5TFE4 5-nucleotidase domain-containing protein 1 NT5DC1 Q9Y266;A0A0A0MSS4;A0A0A0MSU9 Nuclear migration protein nudc NUDC Q96RS6;Q96RS6-3;Q96RS6-2 NudC domain-containing protein 1 NUDCD1 K7EIN2;Q9BRJ7;K7ENA3 Protein syndesmos NUDT16L1 Q9UKK9;A6NFX8;A6NCQ0;A6NJU6 ADP-sugar pyrophosphatase NUDT5 Q ;Q14980;Q ;Q ;Q9BTE9 Nuclear mitotic apparatus protein 1 NUMA1 Q8N1F7;H3BVG0;Q8N1F7-2 Nuclear pore complex protein Nup93 NUP93 P04181;P Ornithine aminotransferase, ;Ornithine aminotransferase, hepatic form;ornithine aminotransferase, renal form OAT Q56VL3 OCIA domain-containing protein 2 OCIAD2 F5H801;Q ;Q02218;E9PDF2;E9R7;E9PFG7 2-oxoglutarate dehydrogenase, OGDH Q9NZT2-2;Q9NZT2 Opioid growth factor receptor OGFR O15294;O ;O ;O UDP-N-acetylglucosamine--peptide N- acetylglucosaminyltransferase 110 kda subunit OGT Q9NTK5;J3KQ32;Q9NTK5-2;Q9NTK5-3 Obg-like ATPase 1 OLA1 O60313;E5KLK1;E5KLJ6;E5KLJ9;O ;E5KLJ5 Dynamin-like 120 kda protein, ;Dynamin-like 120 kda protein, form S1 OPA1 F5GYN4;Q96FW1;J3KR44;F5H6Q1;F5GYJ8;F5H3 F0;Q96FW1-2 Ubiquitin thioesterase OTUB1 OTUB1 P07237;H7BZ94;F5H8J2;H0Y3Z3 Protein disulfide-isomerase P4HB Q9UQ80;F8VR77 Proliferation-associated protein 2G4 PA2G4 A0A087WTT1;P ;P11940;E7EQV3;E7ERJ7;H0YAR2;Q9H361 Polyadenylate-binding protein 1;Polyadenylatebinding protein 3 PAB1;PAB3 S65

66 Q86U42-2;Q86U42;H0YJH9;B4DEH8;G3V4T2;Q Polyadenylate-binding protein 2 PABPN1 P68402;P ;P ;J3KNE3;P Platelet-activating factor acetylhydrolase IB subunit beta PAFAH1B2 M0R389;Q15102 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 P22234;E9PBS1;P ;D6RF62 Multifunctional protein ADE2;Phosphoribosylaminoimidazolesuccinocarboxamide synthase;phosphoribosylaminoimidazole carboxylase PAICS Q13177;B1AKS5;O ;O75914;O ;O Serine/threonine-protein kinase PAK 2;PAK- 2p27;PAK-2p34;Serine/threonine-protein kinase PAK 3 PAK2;PAK3 O43252 Bifunctional 3-phosphoadenosine 5- phosphosulfate synthase 1;Sulfate adenylyltransferase;adenylyl-sulfate kinase PAPSS1 O95340;E7ER89;O Bifunctional 3-phosphoadenosine 5- phosphosulfate synthase 2;Sulfate adenylyltransferase;adenylyl-sulfate kinase PAPSS2 Q99497;K7ELW0;K7EN27 Protein DJ-1 PARK7 P09874 Poly [ADP-ribose] polymerase 1 PARP1 P11498 Pyruvate carboxylase, Q15365 Poly(rC)-binding protein 1 BP1 Q ;Q ;Q15366;Q ;B4DLC0;H3BRU6;G3V0E8;F8VZX2;B4DXP5;Q ;Q ;F8VXH9;F8W0G4 Poly(rC)-binding protein 2 BP2 P ;P05165;P Q16822;H0YML5;B4DW73;Q ;H0YM31 Propionyl-CoA carboxylase alpha chain, Phosphoenolpyruvate carboxykinase [GTP], CA K2 P12004 Proliferating cell nuclear antigen NA Q9UHG3;B7Z3Y2;B7Z9P8;F8W8W4 Prenylcysteine oxidase 1 YOX1 H7C1T3;C9J050;P49585;C9JEJ2;H7BZN1;Q9Y5K 3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3;C9J2E1 Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B YT1A;YT1B Q8WUM4;Q8WUM4-2 Programmed cell death 6-interacting protein PDCD6IP P ;P08559;P ;P Pyruvate dehydrogenase E1 component subunit alpha, somatic form, PDHA1 S66

67 P ;P ;P11177 Pyruvate dehydrogenase E1 component subunit beta, PDHB G5EA52;P30101 Protein disulfide-isomerase A3 PDIA3 G5EA52;P30101 Protein disulfide-isomerase A3 PDIA3 P13667 Protein disulfide-isomerase A4 PDIA4 Q14554 Protein disulfide-isomerase A5 PDIA5 B7Z254;Q15084;F8WA83;B5MCQ5;Q Protein disulfide-isomerase A6 PDIA6 F2Z2Y4;O ;O00764;O Pyridoxal kinase PDXK P30086 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide PEBP1 Q9UBV8 Peflin PEF1 B5MCF9;O ;O00541;B3KXD6 Pescadillo homolog PES1 O ;O96011 Peroxisomal membrane protein 11B PEX11B P17858;P phosphofructokinase, liver type PFKL Q01813;Q phosphofructokinase type C PFKP P07737;K7EJ44 Profilin-1 PFN1 C9J0J7;P ;G5E9Q6 Profilin-2;Profilin PFN2 P18669 Phosphoglycerate mutase 1 PGAM1 P18669;P15259 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 PGAM1;PGAM2 Q96HS1-2;Q96HS1 Serine/threonine-protein phosphatase PGAM5, PGAM5 B4DQJ8;P52209;F5H7U0;K7EM49;K7EMN2 6-phosphogluconate dehydrogenase, decarboxylating PGD P00558;B7Z7A9;E7ERH5 Phosphoglycerate kinase 1;Phosphoglycerate kinase PGK1 M0R261;O95336;M0R0U3 6-phosphogluconolactonase PGLS A6NDG6 Phosphoglycolate phosphatase PGP O00264;B7Z1L3 Membrane-associated progesterone receptor component 1 PGRMC1 O15173;O Membrane-associated progesterone receptor component 2 PGRMC2 P35232;C9JZ20;E7ESE2;E9W0;C9JW96;B4DY 47 Prohibitin Q7RTV0 PHD finger-like domain-containing protein 5A PHF5A O43175;Q5SZU1 D-3-phosphoglycerate dehydrogenase PHGDH Q5JRX3;Q5JRX3-2;Q5JRX3-3 Presequence protease, PITRM1 PHB P14618;P ;P ;H3BTN5;B4DNK4;H3BQ34 Pyruvate kinase PKM;Pyruvate kinase PKM S67

68 P14618;P ;P ;H3BTN5;H3BQ34;Q504U3 Pyruvate kinase PKM;Pyruvate kinase Q9Y446;Q9Y446-2 Plakophilin-3 PKP3 Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;Q Plectin PKM;PKM2 PLEC Q10713 Mitochondrial-processing peptidase subunit alpha PMA O75439;E7ERZ4;G3V0E4 Mitochondrial-processing peptidase subunit beta PMB Q9H307;Q9H307-2 Pinin PNN Q99575 Ribonucleases P/MRP protein subunit POP1 POP1 P16435;H0Y4R2;E7EMD0;F5H468;E7EVY7 NADPH--cytochrome P450 reductase POR Q15181;Q5SQT6 Inorganic pyrophosphatase PPA1 Q9H2U2;Q9H2U2-2;Q9H2U2-3;E2QRM6;Q9H2U2-6;D6R967;B4DFH3;H0Y9D8 Inorganic pyrophosphatase 2, PPA2 Q06203;D6RCC8 Amidophosphoribosyltransferase PPAT P62937;F8WE65;C9J5S7;Q567Q0 Peptidyl-prolyl cis-trans isomerase A;Peptidylprolyl cis-trans isomerase A, N-terminally processed;peptidyl-prolyl cis-trans isomerase PPIA P23284 Peptidyl-prolyl cis-trans isomerase B PPIB P30405 Peptidyl-prolyl cis-trans isomerase F, ;Peptidyl-prolyl cis-trans isomerase PPIF O15355 Protein phosphatase 1G PPM1G P62136;P ;E9PMD7;P Serine/threonine-protein phosphatase PP1- alpha catalytic subunit;serine/threonine-protein phosphatase PPP1CA P62140;E7ETD8 Serine/threonine-protein phosphatase PP1-beta catalytic subunit PPP1CB F8VYE8;P36873;P ;F8W0W8;F8VR82 Serine/threonine-protein phosphatase;serine/threonine-protein phosphatase PP1-gamma catalytic subunit PPP1CC P ;P67775;P62714 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;serine/threonineprotein phosphatase 2A catalytic subunit beta isoform PPP2CA;PPP2CB P30153;F5H3X9;B3KQV6;C9J9C1 Serine/threonine-protein phosphatase 2A 65 kda regulatory subunit A alpha isoform PPP2R1A S68

69 P63151;P Serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B alpha isoform PPP2R2A P63151;P ;E5RIY1;Q66LE6 Serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B alpha isoform;serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B delta isoform PPP2R2A;PPP2R2D A6PVN6;Q5T949;Q5T948;Q ;Q ;A6PVN5;Q15257;B4DZF8;A6PVN7;A6PVN8;C9I Z76;A6PVN9 Serine/threonine-protein phosphatase 2A activator PPP2R4 Q ;Q ;A6PVN5;Q15257;F6WIT2;Q68CR8;A6PVN6;Q5 T949;Q5T948;A6PVN9;Q Serine/threonine-protein phosphatase 2A activator PPP2R4;DKFZp781M17165 Q9NY27;Q9NY27-3;C9IZ04;Q9NY27-2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 Q06830 Peroxiredoxin-1 PRDX1 P32119;A6NIW5 Peroxiredoxin-2 PRDX2 E9PH29;P30048 Thioredoxin-dependent peroxide reductase, PRDX3 Q13162;H7C3T4 Peroxiredoxin-4 PRDX4 P ;P30044;P ;P Peroxiredoxin-5, PRDX5 P30041 Peroxiredoxin-6 PRDX6 P10644;K7EM13;K7ER48;K7EPB2 camp-dependent protein kinase type I-alpha regulatory subunit;camp-dependent protein kinase type I-alpha regulatory subunit, N- terminally processed PRKAR1A P ;P14314;K7ELL7 Glucosidase 2 subunit beta PRKCSH P78527;E7EUY0;P DNA-dependent protein kinase catalytic subunit PRKDC E9PKG1;Q ;Q ;Q ;Q99873;H7C2I1;E9PIX6;E9PQ98;E9PNR9;H0Y DE4 Protein arginine N-methyltransferase 1 PRMT1 Q96LA8-2;Q96LA8 Protein arginine N-methyltransferase 6 PRMT6 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 O ;O ;O75400 Pre-mRNA-processing factor 40 homolog A PRPF40A O ;O94906 Pre-mRNA-processing factor 6 PRPF6 Q6P2Q9;I3L0J9 Pre-mRNA-processing-splicing factor 8 PRPF8 P25786;P ;F5GX11;B4DEV8 Proteasome subunit alpha type-1 PSMA1 P25787 Proteasome subunit alpha type-2 PSMA2 P ;P25788 Proteasome subunit alpha type-3 PSMA3 S69

70 H0YMZ1;H0YN18;H0YL69;P25789;P ;H0YKT8;H0YMA1 Proteasome subunit alpha type;proteasome subunit alpha type-4;proteasome subunit beta type PSMA4 P28066 Proteasome subunit alpha type-5 PSMA5 P60900;G3V5Z7;G3V3U4;G3V3I1;G3V295;B4DXJ 9 Proteasome subunit alpha type-6;proteasome subunit alpha type PSMA6 O14818;O ;H0Y586;Q8TAA3-2;Q8TAA3-5;Q8TAA3 Proteasome subunit alpha type-7;proteasome subunit alpha type-7-like PSMA7;PSMA8 P20618 Proteasome subunit beta type-1 PSMB1 P49721 Proteasome subunit beta type-2 PSMB2 J3KSM3;J3KRR2;J3QKR3;P49720 Proteasome subunit beta type-3 PSMB3 P28070 Proteasome subunit beta type-4 PSMB4 P28074;P Proteasome subunit beta type-5 PSMB5 P28072 Proteasome subunit beta type-6 PSMB6 Q99436 Proteasome subunit beta type-7 PSMB7 P ;P S protease regulatory subunit 4 PSMC1 P35998;B7Z5E2 26S protease regulatory subunit 7 PSMC2 P43686;P S protease regulatory subunit 6B PSMC4 J3QSA9;J3QQM1;P ;P62195;J3QLH6;J3KRP2 26S protease regulatory subunit 8 PSMC5 P62333;H0YJC0 26S protease regulatory subunit 10B PSMC6 Q ;Q S proteasome non-atpase regulatory subunit 1 PSMD1 O00231;O S proteasome non-atpase regulatory subunit 11 PSMD11 O00232;O S proteasome non-atpase regulatory subunit 12 PSMD12 J3KNQ3;Q9UNM6;Q9UNM6-2;H0YD73;E9PL38 26S proteasome non-atpase regulatory subunit 13 PSMD13 O S proteasome non-atpase regulatory subunit 14 PSMD14 E7EW34;Q13200;E9S3 26S proteasome non-atpase regulatory subunit 2 PSMD2 O43242;B4DT72 26S proteasome non-atpase regulatory subunit 3 PSMD3 Q ;Q S proteasome non-atpase regulatory subunit 5 PSMD5 Q15008;C9IZE4;E9PHI9;Q S proteasome non-atpase regulatory subunit 6 PSMD6 S70

71 K7EJR3;R4GMR5;P48556;K7EJC1 26S proteasome non-atpase regulatory subunit 8 PSMD8 J3KN29;O00233;F5H169;F5H5V4;F5GX23;F8W7 V8;O S proteasome non-atpase regulatory subunit 9 PSMD9 Q06323;H0YNE3;Q Proteasome activator complex subunit 1 PSME1 Q9UL46;H0YM70 Proteasome activator complex subunit 2 PSME2 Q8WXF1-2;Q8WXF1 Paraspeckle component 1 PS1 P26599;P ;P ;A6NLN1 Polypyrimidine tract-binding protein 1 PTBP1 O ;O ;O ;O95758;O ;O ;O Polypyrimidine tract-binding protein 3 PTBP3 B4DE85;Q9BUQ5;P48651 Phosphatidylserine synthase 1 PTDSS1 Q9H7Z7;A6NHH0 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form PTGES2 B4DP21;B4DP11;Q15185;B4DHP2 Prostaglandin E synthase 3 PTGES3 Q ;Q14914;F2Z3J9;Q5JVP3 Prostaglandin reductase 1 PTGR1 Q9P035;H3BPZ1;H3BS72;B4DRF4 Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 PTPLAD1 P18031;B4DSN5 Tyrosine-protein phosphatase non-receptor type 1;Tyrosine-protein phosphatase non-receptor type PTPN1 Q9Y3E5;J3KQ48 Peptidyl-tRNA hydrolase 2, PTRH2 E9PN18;E9PQ56;H0YEM1;Q9UHX1-4;Q9UHX1-6;Q9UHX1-3;Q9UHX1-5;Q9UHX1-2;Q9UHX1;E9PMU7 Poly(U)-binding-splicing factor PUF60 PUF60 Q15269 Periodic tryptophan protein 2 homolog PWP2 P11216 Glycogen phosphorylase, brain form PYGB B4DWJ2;P47897;H7C0R3 Glutamine--tRNA ligase QARS P61026 Ras-related protein Rab-10 RAB10 P ;H3BMH2;Q ;H3BSC1;P62491;Q15907 Ras-related protein Rab-11A;Ras-related protein Rab-11B RAB11A;RAB11B P61106 Ras-related protein Rab-14 RAB14 Q9NP72;Q9NP72-2;Q9NP72-3;Q5W0J0 Ras-related protein Rab-18 RAB18 E7END7;P62820;P ;Q92928 Ras-related protein Rab-1A;Putative Ras-related protein Rab-1C RAB1A;RAB1C Q9UL25 Ras-related protein Rab-21 RAB21 P ;P61019 Ras-related protein Rab-2A RAB2A P ;P61019;E9PKL7;Q8WUD1 Ras-related protein Rab-2A;Ras-related protein Rab-2B RAB2A;RAB2B O95716 Ras-related protein Rab-3D RAB3D S71

72 P51148;P ;K7ERI8;K7ERQ8;F8VWU4;F8VVZ0;F8VUA5;F8 VVK3;K7ENY4;P ;P20339 Ras-related protein Rab-5C;Ras-related protein Rab-5A RAB5C;RAB5B;RAB5A P51149;C9J592;C9J8S3;C9IZZ0;C9J4V0 Ras-related protein Rab-7a RAB7A P61006;B4DEK7 Ras-related protein Rab-8A RAB8A P63000;P ;B1AH77;B1AH80;P15153;J3KSC4;J3QLK0;B1A H78;P60763 Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 2;Rasrelated C3 botulinum toxin substrate 3 RAC1;RAC2;RAC3 P63000;P ;P60763;P15153 Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 3;Rasrelated C3 botulinum toxin substrate 2 RAC1;RAC3;RAC2 P54727;P ;H0Y579 UV excision repair protein RAD23 homolog B RAD23B P78406;E9PPG9;E9PQ57 mrna export factor RAE1 P62826;B5MDF5;J3KQE5;F5H018;H0YFC6 GTP-binding nuclear protein Ran RAN P ;P ;P62834;P61224;F5H4H0;F5GYH7;F5H077;F5G WU8;F5H491;F5H0B7;F5H500;F5H6R7;F5H004;F 5GYB5;F5GX62;P ;E7ESV4;F5H7Y6;A6NIZ1 Ras-related protein Rap-1b;Ras-related protein Rap-1A;Ras-related protein Rap-1b-like protein RAP1B;RAP1A Q9Y3L5;F6U784;A0A087X2C3;P61225;P10114 Ras-related protein Rap-2c;Ras-related protein Rap-2b;Ras-related protein Rap-2a RAP2C;RAP2A;RAP2B P54136;P ;F5H3T8 Arginine--tRNA ligase, cytoplasmic RARS E952;Q16576;Q Histone-binding protein RBBP7 RBBP7 Q96PK6;Q96PK6-3;Q96PK6-4;F8WDX3;Q96PK6-2;B8ZZ74 RNA-binding protein 14 RBM14 Q9BWF3;E9PB51;Q9BQ04;Q9BWF3-4;Q9BWF3-3;D6R9K7;J3QRR5;Q9BWF3-2 RNA-binding protein 4;RNA-binding protein 4B RBM4;RBM4B Q9Y5S9;Q9Y5S9-2 RNA-binding protein 8A RBM8A H0Y6E7;H3BT71;P38159;P ;H3BR27;P RNA-binding motif protein, X chromosome;rnabinding motif protein, X chromosome, N- terminally processed RBMX P38159;P ;H0Y6E7;H3BT71;Q96E39;H3BUY5 RNA-binding motif protein, X chromosome;rnabinding motif protein, X chromosome, N- terminally processed;rna binding motif protein, X-linked-like-1 RBMX;RBMXL1 C9JW69;P18754;P ;C9JRH2;C9JMJ4;C9J3R0;C9JQZ4 Regulator of chromosome condensation RCC1 Q9P258 Protein RCC2 RCC2 P35241;P ;P Radixin RDX S72

73 Q00765 Receptor expression-enhancing protein 5 REEP5 Q5JR08;P08134;E9PQH6;P61586 Rho-related GTP-binding protein RhoC;Transforming protein RhoA RHOC;RHOA Q8IXI1;H3BST5;I3L2C6;Q8IXI1-2 Mitochondrial Rho GTPase 2 RHOT2 P13489;H0YCR7 Ribonuclease inhibitor RNH1 Q9H4A4;A6NKB8 Aminopeptidase B RNPEP P27694;I3L524;I3L2M5 Replication protein A 70 kda DNA-binding subunit;replication protein A 70 kda DNAbinding subunit, N-terminally processed RPA1 P27635;F8W7C6 60S ribosomal protein L10 RPL10 P S ribosomal protein L10a RPL10A P ;P62913;Q5VVC9;Q5VVC8 60S ribosomal protein L11 RPL11 P30050;P S ribosomal protein L12 RPL12 P26373;J3QSB4;P S ribosomal protein L13 RPL13 P40429;M0QYS1;Q8J015;Q6NVV1 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a-like MGC87657 RPL13A;RPL13a E7EPB3;P S ribosomal protein L14 RPL14 P61313;E7EQV9;E7EX53;E7ENU7;P J3QQT2;J3KRX5;P18621;P ;P ;J3QLC8;J3QS96;J3KRB3 60S ribosomal protein L15;Ribosomal protein L15 60S ribosomal protein L17 RPL15 RPL17 Q07020;J3QQ67;F8VWC5;G3V203;H0YHA7;F8V YV2;F8VUA6 60S ribosomal protein L18 RPL18 M0R117;Q02543;M0R3D6;M0R1A7;M0R0P7 60S ribosomal protein L18a RPL18A J3QR09;J3KTE4;P84098;J3QL15 Ribosomal protein L19;60S ribosomal protein L19 RPL19 G3V1B3;M0R181;P S ribosomal protein L21 RPL21 K7EP65;K7EKS7;K7ELC4;K7EMH1;K7ERI7;P352 68;K7EJT5 60S ribosomal protein L22 RPL22 C9JD32;B9ZVP7;J3KT29;P S ribosomal protein L23 RPL23 C9JXB8;C9JNW5;P S ribosomal protein L24 RPL24 J3KTJ8;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC 4;Q9UNX3;P S ribosomal protein L26-like 1;60S ribosomal protein L26 RPL26;KRBA2;RPL26L1 P46776;E9PLL6;E9PJD9 60S ribosomal protein L27a RPL27A P46779;P ;P ;H0YKD8;P ;P ;H0YLP6;H0YMF4 60S ribosomal protein L28 RPL28 P S ribosomal protein L29 RPL29 P39023;H7C422;G5E9G0;H7C3M2;B5MCW2 60S ribosomal protein L3 RPL3 E5RI99;P S ribosomal protein L30 RPL30 P S ribosomal protein L34 RPL34 S73

74 P36578;H3BM89 60S ribosomal protein L4 RPL4 P46777;Q5T7N0 60S ribosomal protein L5 RPL5 Q S ribosomal protein L6 RPL6 P18124;A8MUD9 60S ribosomal protein L7 RPL7 P62424;Q5T8U2;Q5T8U3 60S ribosomal protein L7a RPL7A E9PKZ0;P62917;G3V1A1;E9PKU4 60S ribosomal protein L8 RPL8 D6RAN4;P32969;H0Y9V9;E7ESE0 60S ribosomal protein L9 RPL9 P05388;Q3B7A4;F8VWS0;F8VU65;F8VPE8;G3V2 10;F8VW21;F8VQY6;F8VRK7;F8VZS0;Q8NHW5; F8VS58 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like RPLP0;RPLP0P6 P S acidic ribosomal protein P1 RPLP1 P04843;B7Z4L4 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN1 P ;P04844;Q5JYR4;Q5JYR7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN2 P46783;F6U211;S4R435;Q9NQ39 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like RPS10;RPS10P5 P62280;M0QZC5 40S ribosomal protein S11 RPS11 P S ribosomal protein S12 RPS12 P62277;E9PS50;J3KMX5 40S ribosomal protein S13 RPS13 P62263;H0YB22;E5RH77 40S ribosomal protein S14 RPS14 I3L3P7;P62244;I3L246;H3BN98 40S ribosomal protein S15a RPS15A P62249;M0R210;M0R3H0 40S ribosomal protein S16 RPS16 P0CW22;P08708;H0YN88;H0YK46 40S ribosomal protein S17-like;40S ribosomal protein S17 RPS17L;RPS17 P S ribosomal protein S18 RPS18 P15880;H0YEN5;E9PQD7;E9PMM9 40S ribosomal protein S2 RPS2 P60866;P ;E5RJX2;E5RIP1 40S ribosomal protein S20 RPS20 Q8WVC2;P63220;Q9BYK1 40S ribosomal protein S21 RPS21 P62266;D6RD47 40S ribosomal protein S23 RPS23 P S ribosomal protein S25 RPS25 P62854;Q5JNZ5 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 RPS26;RPS26P11 P42677;Q5T4L4;Q71UM5;H0YMV8 40S ribosomal protein S27;40S ribosomal protein S27-like RPS27;RPS27L S74

75 P62979;J3QS39;J3QTR3;F5H6Q2;P62987;F5GYU 3;F5H2Z3;F5H265;B4DV12;F5H388;F5H747;F5G XK7;J3QKN0;P0CG47;Q96C32;F5H041;P0CG48; M0R1V7;M0R1M6;M0R2S1;J3QLP7;J3QRK5 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin;Polyubiquitin- C;Ubiquitin RPS27A;UBB;UBC;UBA52; UBBP4 P S ribosomal protein S28 RPS28 P23396;P ;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;H0YF32;H0Y EU2 P61247;D6RG13;D6RAT0;F5H4F9;D6RB09;E9PFI 5;H0Y8L7;H0Y9Y4;D6RAS7;D6R9B6 40S ribosomal protein S3 40S ribosomal protein S3a RPS3 RPS3A P S ribosomal protein S4, X isoform RPS4X M0R0F0;P46782;M0QZN2;M0R0R2 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed RPS5 P62753;A2A3R5 40S ribosomal protein S6 RPS6 Q7Z721;B4DLT4;P ;F6UYM1;P23443 Ribosomal protein S6 kinase beta-1 RPS6KB1 B5MCP9;P S ribosomal protein S7 RPS7 P62241;Q5JR95 40S ribosomal protein S8 RPS8 P46781;B5MCT8;C9JM19 40S ribosomal protein S9 RPS9 C9J9K3;P08865;A6NE09 40S ribosomal protein SA RPSA;RPSAP58 E9PD78;P23921;E9PL69;F5H861 Ribonucleoside-diphosphate reductase;ribonucleoside-diphosphate reductase large subunit RRM1 J3QSV6;O76021;I3L3U9;I3L3C4 Ribosomal L1 domain-containing protein 1 RSL1D1 Q9BY42;A0A0A0MQR2;A2A2L5 Protein RTF2 homolog RTFDC1 O ;O ;O ;O ;O95197;B7Z4M1;O ;O Reticulon-3 RTN3 F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;Q9NQC3-3;H7C106;Q9NQC3-4;F8WAM4;Q9NQC3-6 Reticulon-4 RTN4 Q9Y265;H7C4G5;E7ETR0;Q9Y265-2;J3QLR1 RuvB-like 1 RUVBL1 Q9Y230;B3KQ59;M0R0Y3 RuvB-like 2 RUVBL2 P60903 Protein S100-A10 S100A10 P31949 Protein S100-A11 S100A11 Q9HCY8 Protein S100-A14 S100A14 Q96FQ6 Protein S100-A16 S100A16 Q ;Q15424;Q ;Q ;F5GZU3;B7Z2F6 Scaffold attachment factor B1 SAFB Q14151 Scaffold attachment factor B2 SAFB2 S75

76 Q9Y512 Sorting and assembly machinery component 50 homolog SAMM50 P82979;F8VZQ9;H0YHG0 SAP domain-containing ribonucleoprotein SARNP P49591;Q5T5C7 Serine--tRNA ligase, cytoplasmic SARS Q15020;F8VV04;B7ZKM0 Squamous cell carcinoma antigen recognized by T-cells 3 SART3 Q8NBX0 Saccharopine dehydrogenase-like oxidoreductase SCCPDH P ;P ;P ;P22307;P ;P Non-specific lipid-transfer protein SCP2 B4DIV7;Q ;Q12765;Q Secernin-1 SCRN1 D6RFM5;E9PBJ5;P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, SDHA A8MXL6;P ;P55735;B4DXJ1 Protein SEC13 homolog SEC13 O75396 Vesicle-trafficking protein SEC22b SEC22B F5H365;Q15436;B3KXI2;F5H6C4 Protein transport protein Sec23A SEC23A E7EP00;G5EA31;P53992 Protein transport protein Sec24C SEC24C P61619;B4DR61;H7C1Q9;C9JXC6;H7C069;A6NK 38;F2Z2C7;A6NIF9;C9JJV4;P ;F8W776;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 SEC61A1;SEC61A2 P60468 Protein transport protein Sec61 subunit beta SEC61B Q13228;A6PVW9;Q ;A6PVX1;Q ;H0Y532 Selenium-binding protein 1 SELENBP1 A0A087X142;Q ;A6NMH6;A6NFQ9;Q ;F8W8I8;Q92599;Q Septin-2 Septin-7 Septin-8 SEPT2 SEPT7 SEPT8 Q8NC51-4;Q8NC51-3;Q8NC51-2;Q8NC51 Septin-9 Plasminogen activator inhibitor 1 RNA-binding protein SEPT9 SERBP1 P50454;E9PR70;E9PPV6;E9PKH2 Serpin H1 SERPINH1 Q ;Q ;Q ;Q01105 Protein SET SET E7EUT8;Q12874 Splicing factor 3A subunit 3 SF3A3 O75533 Splicing factor 3B subunit 1 SF3B1 Q13435;E9PPJ0 Splicing factor 3B subunit 2 SF3B2 Q15393 Splicing factor 3B subunit 3 SF3B3 P ;P protein sigma SFN S76

77 P23246;P Splicing factor, proline- and glutamine-rich SFPQ B4E241;P84103 Serine/arginine-rich splicing factor 3 SFRS3;SRSF3 Q9H9B4;D6RFI0 Sideroflexin-1 SFXN1 Q96NB2 Sideroflexin-2 SFXN2 O95470 Sphingosine-1-phosphate lyase 1 SGPL1 Q9NR46;B7ZC38;B7ZC39;Q9NR46-2 Endophilin-B2 SH3GLB2 P ;P34897;P ;B4DLV4;H0YIZ0;G3V2Y4 Serine hydroxymethyltransferase, ;Serine hydroxymethyltransferase SHMT2 M0QXM4;Q15758;Q ;Q Neutral amino acid transporter B(0) SLC1A5 P53007 Tricarboxylate transport protein, SLC25A1 B4E1E9;Q9UBX3;Q9UBX3-2;B4DLN1;I3L1E8 Mitochondrial dicarboxylate carrier SLC25A10 I3L1P8;Q02978;Q Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Q9UJS0;Q9UJS0-2;F5GX33 Calcium-binding carrier protein Aralar2 SLC25A13 Q9UJS0;Q9UJS0-2;O ;O75746 Calcium-binding carrier protein Aralar2;Calcium-binding carrier protein Aralar1 SLC25A13;SLC25A12 B4DWZ5;O43772;C9JPE1 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 Q6NUK1;Q6NUK1-2 Calcium-binding carrier protein SCaMC-1 SLC25A24 Q ;Q00325;F8VVM2 Phosphate carrier protein, SLC25A3 P05141 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed SLC25A5 P12236;I7HJJ0;P12235 ADP/ATP translocase 3;ADP/ATP translocase 1 SLC25A6;SLC25A4 Q5K4L6;Q5K4L6-2 Long-chain fatty acid transport protein 3 SLC27A3 P ;P ;F5GZS6;P08195;J3KPF3;P F2 cell-surface antigen heavy chain SLC3A2 Q9UN76 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 O14745;J3QRP6 Na(+)/H(+) exchange regulatory cofactor NHE- RF1 SLC9A3R1 O60264 SWI/SNF-related matrix-associated actindependent regulator of chromatin subfamily A member 5 SMARCA5 Q8TAQ2;Q8TAQ2-2;Q8TAQ2-3;F8VXC8 SWI/SNF complex subunit SMARCC2 SMARCC2 S77

78 Q14683 Structural maintenance of chromosomes protein 1A SMC1A Q9H0W8-2;Q9H0W8 Protein SMG9 SMG9 Q2TAY7;B4E3L0 WD40 repeat-containing protein SMU1 SMU1 Q7KZF4 O75643 Staphylococcal nuclease domain-containing protein 1 U5 small nuclear ribonucleoprotein 200 kda helicase SND1 SNRNP200 Q96DI7;Q9NSS8;B4DQJ1 U5 small nuclear ribonucleoprotein 40 kda protein SNRNP40;DKFZp434D199 P08621;P ;P ;M0QYR1 U1 small nuclear ribonucleoprotein 70 kda SNRNP70 P ;P14678;P ;J3QLE5;P63162;B3KVR1 Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N;Small nuclear ribonucleoprotein-associated protein SNRPB;SNRPN P ;P62316;K7EJB5;K7ERG4 Small nuclear ribonucleoprotein Sm D2 SNRPD2 P ;P62318;H3BT13 Small nuclear ribonucleoprotein Sm D3 SNRPD3 G3V4X8;Q13573;G3V3A4 SNW domain-containing protein 1 SNW1 P35270 Sepiapterin reductase SPR Q ;Q13813;Q ;A6NG51 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 O ;O15020 Spectrin beta chain, non-erythrocytic 2 SPTBN2 O15269 Serine palmitoyltransferase 1 SPTLC1 C9J0K6;P ;P ;P30626 Sorcin SRI P19623;K7EKM4;K7ESL0 Spermidine synthase SRM P37108;H0YLA2 Signal recognition particle 14 kda protein SRP14 F5H5Y3;Q9UHB9-4;Q9UHB9-2;Q9UHB9;Q9UHB9-3 Signal recognition particle subunit SRP68 SRP68 P49458;E9PE20;P Signal recognition particle 9 kda protein SRP9 Q9Y5M8;H7C4H2 Signal recognition particle receptor subunit beta SRPRB Q9UQ35 Serine/arginine repetitive matrix protein 2 SRRM2 H7C3A1;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 Serrate RNA effector molecule homolog SRRT Q07955;J3KTL2;Q ;Q Serine/arginine-rich splicing factor 1 SRSF1 A0A087X2D0;P ;P84103 Serine/arginine-rich splicing factor 3 SRSF3 Q ;Q13243 Serine/arginine-rich splicing factor 5 SRSF5 Q ;Q13247 Serine/arginine-rich splicing factor 6 SRSF6 S78

79 Q ;Q13247;Q08170 Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 4 SRSF6;SRSF4 Q ;Q ;Q ;C9JAB2;Q16629 Serine/arginine-rich splicing factor 7 SRSF7 S4R3G0;Q13242;H0YIB4 Serine/arginine-rich splicing factor 9 SRSF9 P05455;E9PFL9;E7ERC4 Lupus La protein SSB H7C3I1;F6VDH7;Q3KNR6;Q8IZP2;A0A087X1H6; P50502;Q8NFI4 Putative protein FAM10A4;Hsc70-interacting protein;putative protein FAM10A5 ST13;ST13P4;ST13P5 F5H1Z6;F5H8H3;Q9Y365;F5H8G1;F5GY11;F5H0 V7;H0YGA9;H0YFF3;F5GWK5;H0YH17 TP-like protein STARD10 P42224;P ;J3KPM9 Signal transducer and activator of transcription 1-alpha/beta STAT1 K7ENL3;P ;P40763;G8JLH9 Signal transducer and activator of transcription 3 STAT3 P31948;F5H0T1;G3XAD8 Stress-induced-phosphoprotein 1 STIP1 B4E1K7;Q9UJZ1 Stomatin-like protein 2, STOML2 P46977;E9PNQ1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B STT3B Q9UNE7-2;Q9UNE7;H3BTA3;H3BUD0;H3BS86 E3 ubiquitin-protein ligase CHIP STUB1 O00186 Syntaxin-binding protein 3 STXBP3 F5GXC8;Q9P2R7-2;Q9P2R7;Q5T9Q5;F5H5G8 Succinyl-CoA ligase [ADP-forming] subunit beta, SUCLA2 P53597 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, SUCLG1 Q96I99;H0Y852;E9PDQ8;Q96I99-2 Succinyl-CoA ligase [GDP-forming] subunit beta, SUCLG2 Q9Y2Z0-2;Q9Y2Z0;F5H5A9 Suppressor of G2 allele of SKP1 homolog SUGT1 Q9Y5B9 FACT complex subunit SPT16 SUPT16H O ;O00267 Transcription elongation factor SPT5 SUPT5H O ;Q5T8U5;O15260;B7Z6A4 Surfeit locus protein 4 SURF4 O ;O ;O ;O60506;O Heterogeneous nuclear ribonucleoprotein Q SYNCRIP O43760;O ;K7ELD9;K7ENG9;K7ELS8 Synaptogyrin-2 SYNGR2 S79

80 Q9BSH4 Translational activator of cytochrome c oxidase 1 TACO1 P37802 Transgelin-2 TAGLN2 P37837;F2Z393 Transaldolase TALDO1 Q13148;B1AKP7;G3V162;K7EJM5;K7EN94;B4DJ 45 TAR DNA-binding protein 43 TARDBP E5RIW3;O75347;E5RJD8;E5RHG6;B4DT30 Tubulin-specific chaperone A TBCA Q969Z0;H7C4R5;C9IZN7 Protein TBRG4 TBRG4 R4GMY8;E5RHG8;Q ;Q15369 Transcription elongation factor B polypeptide 1 TCEB1 H3BQ53;Q9BQ70;H3BSS3;Q9H384 Transcription factor 25 TCF25 P17987;E7EQR6;F5H282;E7ERF2 T-complex protein 1 subunit alpha TCP1 Q9NZ01;B3KSQ1 Very-long-chain enoyl-coa reductase TECR G3V0E5;P02786;F5H6B1 Transferrin receptor protein 1;Transferrin receptor protein 1, serum form TFRC Q8WUY1 Protein THEM6 THEM6 Q8IYQ7 Threonine synthase-like 1 THNSL1 Q9Y2W1 Thyroid hormone receptor-associated protein 3 THRAP3 Q9NQ88 Fructose-2,6-bisphosphatase TIGAR TIGAR Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;Q3ZCQ8-3 Mitochondrial import inner membrane translocase subunit TIM50 TIMM50 P29401;P ;B4E022;E9PFF2 Transketolase TKT F5GYV3;O76062;H0YEN6;E9PS18;E9PLS9;O Delta(14)-sterol reductase TM7SF2 Q99805 Transmembrane 9 superfamily member 2 TM9SF2 Q9HD45;Q5TB53 Transmembrane 9 superfamily member 3 TM9SF3 G3V2K7;P49755 Transmembrane emp24 domain-containing protein 10 TMED10 Q9Y3Q3;G3V1J9;F5H4M7;Q9Y3Q3-2 Q9Y3B3-2;Q9Y3B3;Q86XR7-2 Transmembrane emp24 domain-containing protein 3 Transmembrane emp24 domain-containing protein 7 TMED3 TMED7 K7ELQ9;Q6UW68;K7EM09;K7EPR0 Transmembrane protein 205 TMEM205 Q5BJF2;Q86XC5;J3KT68;J3KTD1 Transmembrane protein 97 TMEM97 G5E972;P42167;P ;H0YJH7 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopoietin;thymopentin TMPO G5E972;P42167;P ;H0YJH7 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopoietin;thymopentin TMPO Q9H3N1 Thioredoxin-related transmembrane protein 1 TMX1 O96008 Mitochondrial import receptor subunit TOM40 homolog TOMM40 S80

81 O94826 Mitochondrial import receptor subunit TOM70 TOMM70A P11387 DNA topoisomerase 1 TOP1 E9Y5;Q ;Q02880 O43399;O ;A0A087WYR3;O ;O ;O ;O ;O DNA topoisomerase 2-beta;DNA topoisomerase 2 Tumor protein D54 TOP2B TPD52L2 P ;P60174;P ;U3KPZ0 Triosephosphate isomerase TPI1 J3KN67;P06753;Q5VU63 Tropomyosin alpha-3 chain TPM3 P67936;P Tropomyosin alpha-4 chain TPM4 P13693;Q5W0H4;H0YCX0;Q8TBK7;Q56UQ5;J3K PG2;E9PJF7 Translationally-controlled tumor protein;tpt1- like protein TPT1 P ;P62995;H7BXF3;H7C2L4 Transformer-2 protein homolog beta TRA2B F5H897;Q12931;I3L0K7 Heat shock protein 75 kda, TRAP1 E9PKS9;B4DME1;E9PQE8;Q9Y296;E9PN70;G3V 1A0;G5EA23;J3KP27 Trafficking protein particle complex subunit 4 TRAP4 Q14258 E3 ubiquitin/isg15 ligase TRIM25 TRIM25 Q13263;Q Transcription intermediary factor 1-beta TRIM28 H0Y612;Q9UPN9-2;Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 F5GX77;Q9UI30;J3KNG5;F5GYQ2;M0R242 trna methyltransferase 112 homolog TRMT112 F5H442;Q99816;Q Tumor susceptibility gene 101 protein TSG101 B1AH87;P30536 Translocator protein TSPO Q16762 Thiosulfate sulfurtransferase TST E9PKL9;Q13630;E9PP60;E9PLH9;E9PP14 GDP-L-fucose synthase TSTA3 P68363;P ;P ;P68366 Tubulin alpha-1b chain;tubulin alpha-4a chain TUBA1B;TUBA4A Q9BQE3;F5H5D3 Tubulin alpha-1c chain TUBA1C Q5JP53;P07437;Q5ST81 Tubulin beta chain TUBB Q13509;A8K854 Tubulin beta-3 chain TUBB3 P68371;P04350 Tubulin beta-4b chain;tubulin beta-4a chain TUBB4B;TUBB4A Q3ZCM7;F5H0I4;Q5SQY0 Tubulin beta-8 chain TUBB8 P49411 Elongation factor Tu, TUFM Q ;Q12792;F8VS81;Q Twinfilin-1 TWF1 P10599;P Thioredoxin TXN O95881 Thioredoxin domain-containing protein 12 TXNDC12 Q9BRA2;I3L0K2;I3L3M7;I3L2R6 Thioredoxin domain-containing protein 17 TXNDC17 Q86UY0;Q8NBS9;Q8NBS9-2 Thioredoxin domain-containing protein 5 TXNDC5 S81

82 F5H1L4;E7ENA2;Q9NNW7-2;F5H2V0;D3YTF9;Q9NNW7;E7EWK1;Q9NNW7-3;D3YTF8 Thioredoxin reductase 2, TXNRD2 Q ;Q01081;Q Splicing factor U2AF 35 kda subunit U2AF1 K7ENG2;P ;P26368 Splicing factor U2AF 65 kda subunit U2AF2 O ;O ;E7ET15;O15042;C9JB80 U2 snrnp-associated SURP motif-containing protein U2SURP P22314 Ubiquitin-like modifier-activating enzyme 1 UBA1 Q9UBT2;K7EPL2 SUMO-activating enzyme subunit 2 UBA2 A0AVT1;A0AVT1-4;A0AVT1-3 Ubiquitin-like modifier-activating enzyme 6 UBA6 J3QS39;J3QTR3;F5H6Q2;P62987;F5GYU3;F5H2 Z3;F5H265;B4DV12;F5H388;P62979;F5H747;F5G XK7;J3QKN0;Q5PY61;P0CG47;Q96C32;P0CG48; M0R1V7;A0A087WV77;M0R1M6;M0R2S1;J3QLP 7;J3QRK5;J3QSA3;K7EMA8;F5GZ39 Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-B;Ubiquitin;Polyubiquitin- C;Ubiquitin UBB;RPS27A;UBC;UBA52; UBBP4 P ;P68036;P Ubiquitin-conjugating enzyme E2 L3 UBE2L3 P61088;Q5JXB2;F8VZ29;F8VQQ8;F8VSD4;F8VV 71 Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like UBE2N;UBE2NL Q13404;Q ;Q ;Q ;I3L0A0;Q ;G3V2F7;Q15819;E5RIF1;D6RG00;Q ;A0A0A0MSL3;G3V113;H0YBX6 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 UBE2V1;TMEM189;UBE2V 2 Q14139;Q Ubiquitin conjugation factor E4 A UBE4A P ;E9PKP7;P17480 Nucleolar transcription factor 1 UBTF O ;O ;O94874 E3 UFM1-protein ligase 1 UFL1 O60701;O ;O UDP-glucose 6-dehydrogenase UGDH Q ;Q16851;A0A087WYS1;E7EUC7 UTP--glucose-1-phosphate uridylyltransferase UGP2 Q9H3U1-2;Q9H3U1 Protein unc-45 homolog A UNC45A Q ;Q92900 Regulator of nonsense transcripts 1 UPF1 P31930 Cytochrome b-c1 complex subunit 1, P22695;H3BRG4;H3BSJ9;H3BP04 Cytochrome b-c1 complex subunit 2, UQCRC1 UQCRC2 S82

83 P47985;P0C7P4 Cytochrome b-c1 complex subunit Rieske, ;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1;UQCRFS1P1 Q96IX5 Up-regulated during skeletal muscle growth protein 5 USMG5 H0Y7C0;F5H4X1;O60763;F5GYR8;O General vesicular transport factor p115 USO1 Q14694;Q ;Q Ubiquitin carboxyl-terminal hydrolase 10 USP10 P ;P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP5 B7Z815;Q93009;F5H8E5;H3BND8;F5H2X1 Ubiquitin carboxyl-terminal hydrolase;ubiquitin carboxyl-terminal hydrolase 7 USP7 Q9P0L0;Q9P0L0-2 Vesicle-associated membrane proteinassociated protein A VAPA O95292 Vesicle-associated membrane proteinassociated protein B/C VAPB P26640 Valine--tRNA ligase VARS P55072 Transitional endoplasmic reticulum ATPase VCP P21796;C9JI87 P45880;P ;P ;Q5JSD2;Q5JSD1;B4DKM5 Q9Y277;Q9Y277-2;F5H740;E5RJN6;E5RHZ6 F5H2J3;Q96GC9;K7EL93;K7EL74;K7ENU2;K7EK 01;K7EMI0;K7ELS2 Voltage-dependent anion-selective channel protein 1 Voltage-dependent anion-selective channel protein 2 Voltage-dependent anion-selective channel protein 3 Vacuole membrane protein 1 VDAC1 VDAC2 VDAC3 VMP1 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 Q96QK1 Vacuolar protein sorting-associated protein 35 VPS35 Q9NRW7;F5H8K1;F5GYC3 Vacuolar protein sorting-associated protein 45 VPS45 O75083;D6RD66 WD repeat-containing protein 1 WDR1 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0 WD repeat-containing protein 18 WDR18 O14980 Exportin-1 XPO1 P13010 X-ray repair cross-complementing protein 5 XRCC5 P12956;B1AHC9;B1AHC8;F5H1I8 X-ray repair cross-complementing protein 6 XRCC6 Q9H0D6-2;B4DZC3;Q9H0D6 5-3 exoribonuclease 2 XRN2 Q9BYJ9;A0A024R7W5;A0A087X0Q1;Q7Z739;A0 A087WY31;Q9Y5A9-2;A0A087WXZ3;Q9Y5A9 YTH domain family protein 1;YTH domain family protein 3;YTH domain family protein 2 YTHDF1;YTHDF3;YTHDF2 S83

84 P ;P protein beta/alpha; protein beta/alpha, N-terminally processed YWHAB P62258;P ;B4DJF2;I3L3T protein epsilon YWHAE P protein gamma; protein gamma, N- terminally processed YWHAG Q04917;A2IDB protein eta YWHAH P27348;E9PG protein theta YWHAQ P63104;E7EX29;B0AZS6;E7ESK7;P protein zeta/delta YWHAZ O75844 CAAX prenyl protease 1 homolog ZMPSTE24 O ;O15231;O ;O ;O ;O ;H0Y704;J3KNL4;H7BZT5;O ;O Zinc finger protein 185 ZNF185 J3KS31;O ;O ;O43670;J3QRS9;O Zinc finger protein 207 ZNF207 S84

85 Table S2: Competitive ABPP-SILAC with 200 nm AA-CW236 pretreatment followed by AA-CW159A treatment. Protein IDs Protein names Gene names SILAC ratio AA- CW236/DMSO SEM P16455 Methylated-DNA--protein-cysteine methyltransferase MGMT Q9H7Z7;A6NHH0; X6RJ95 P61966;H7C1E4; P P01111;P ;P01116;P01112 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form PTGES AP-1 complex subunit sigma-1a AP1S GTPase NRas;GTPase KRas;GTPase KRas, N- terminally processed;gtpase HRas;GTPase HRas, N- terminally processed NRAS;KRAS; HRAS P ;P21964 Catechol O-methyltransferase COMT O94906;O Pre-mRNA-processing factor 6 PRPF O60264 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 SMARCA Q9Y3D2 Methionine-R-sulfoxide reductase B2, MSRB Q9Y4X0-3;Q9Y4X0;Q9Y4X 0-4 AMME syndrome candidate gene 1 protein AMMECR P51570;P Galactokinase GALK P60228;E5RGA2 Eukaryotic translation initiation factor 3 subunit E EIF3E O ;O96008;K7EKG 4;K7EJ57 P62263;H0YB22;E 5RH77 Q7L1Q6-2;Q7L1Q6;Q7L1Q 6-4;Q7L1Q6-3;C9IZ80 Q9UPN9-2;H0Y612;E7EN2 0;Q9UPN9 Mitochondrial import receptor subunit TOM40 homolog TOMM S ribosomal protein S14 RPS Basic leucine zipper and W2 domain-containing protein 1 BZW E3 ubiquitin-protein ligase TRIM33 TRIM P15311;E7EQR4 Ezrin EZR Q12765;Q ;Q Secernin-1 SCRN O ;O95671;O95671 N-acetylserotonin O-methyltransferase-like protein ASMTL Q14151 Scaffold attachment factor B2 SAFB R4GMY8;E5RHG8 ;Q ;Q15369 Transcription elongation factor B polypeptide 1 TCEB Q96IX5 Up-regulated during skeletal muscle growth protein 5 USMG Q08J23-2;Q08J23;Q08J23-3 Q07021;I3L3Q7;I3 L3B0 A0A087WTS8;A0 A087WYC1;P trna (cytosine(34)-c(5))-methyltransferase NSUN Complement component 1 Q subcomponent-binding protein, C1QBP Heat shock 70 kda protein 4 HSPA P09874 Poly [ADP-ribose] polymerase 1 PARP Q3LIE7;Q ;Q15392 Delta(24)-sterol reductase Nbla03646;DH CR S85

86 B1AHF3;P ;P00387;P NADH-cytochrome b5 reductase 3;NADH-cytochrome b5 reductase 3 membrane-bound form;nadh-cytochrome b5 reductase 3 soluble form CYB5R P49588;P ;H3BPK7 H7BZN1;H7C1T3; C9J050;P49585;C 9JEJ2;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3 C9JDR0;Q15738 Alanine--tRNA ligase, cytoplasmic AARS Choline-phosphate cytidylyltransferase A;Cholinephosphate cytidylyltransferase B Sterol-4-alpha-carboxylate decarboxylating 3-dehydrogenase, YT1A;Y T1B NSDHL P53621;P Coatomer subunit alpha;xenin;proxenin COPA P37802;P ;X6RJP6 Transgelin-2 TAGLN Q ;Q ;Q15185;A0A087 Prostaglandin E synthase 3 PTGES WYT3 B5MCF9;O ;O00541;B3KXD Pescadillo homolog PES Q7RTV0 PHD finger-like domain-containing protein 5A PHF5A M0R0F0;P46782; M0R0R2;M0QZN2 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed RPS P15531;P Nucleoside diphosphate kinase A NME Q00688 Peptidyl-prolyl cis-trans isomerase FKBP3 FKBP O60832;H7C0M1; C9IYT0;O ;H7BZF2 P10768;H7BZT7;X 6RA14;U3KQT1 O00483 H/ACA ribonucleoprotein complex subunit 4 DKC S-formylglutathione hydrolase ESD NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA B5MCP9;P S ribosomal protein S7 RPS P33991 DNA replication licensing factor MCM4 MCM P ;P62633;P ;P ;P Cellular nucleic acid-binding protein CNBP ;P ;P ;P O75131 Copine-3 CPNE Q96A33;A0A087 WYW6;Q96A33-2 Coiled-coil domain-containing protein 47 CCDC P55884;P Eukaryotic translation initiation factor 3 subunit B EIF3B P48444;B0YIW6;P Coatomer subunit delta ARCN O15143 Actin-related protein 2/3 complex subunit 1B AR1B P28066 Proteasome subunit alpha type-5 PSMA P78417;Q5TA02;P ;P ;Q5TA01 Q9Y3L5;F6U784; A0A087X2C3;P61 225;P10114 Q9BR76;A0A087 WW53;F5H390 Glutathione S-transferase omega-1 GSTO Ras-related protein Rap-2c;Ras-related protein Rap- 2b;Ras-related protein Rap-2a RAP2C;RAP2 A;RAP2B Coronin-1B;Coronin CORO1B Q15717;Q ELAV-like protein 1 ELAVL S86

87 K7ENA3;K7EIN2; Q9BRJ7;W4VSQ8 ;Q9BRJ7-2 Protein syndesmos NUDT16L P43686;P S protease regulatory subunit 6B PSMC K7ELQ9;Q6UW68 ;K7EM09;K7EPR0 B9A067;Q ;Q ;Q16891;C9J406; Q ;H7C463 Transmembrane protein 205 TMEM Mitochondrial inner membrane protein IMMT P ;P30519;A0A087 WT44;I3L1Y2;I3L1 59;I3L1F5 Q8NC51-4;Q8NC51-3;Q8NC51-2;Q8NC51 P62753;A2A3R5;A 2A3R7 A0A087WXS7;O4 3681;K7ERW9 Heme oxygenase 2 HMOX Plasminogen activator inhibitor 1 RNA-binding protein SERBP S ribosomal protein S6 RPS ATPase ASNA1 ASNA Q9Y512 Sorting and assembly machinery component 50 homolog SAMM Q6YN16;Q6YN16-2 Hydroxysteroid dehydrogenase-like protein 2 HSDL I3L397;P63241;P ;I3L504;F8WCJ1; C9J7B5;C9J4W5; Q9GZV4;Q6IS14 Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like EIF5A;EIF5A2 ;EIF5AL E7ER77;Q7Z2K6 Endoplasmic reticulum metallopeptidase 1 ERMP C9JXB8;C9JNW5; P83731 P30043;M0QZL1; M0R192 60S ribosomal protein L24 RPL Flavin reductase (NADPH) BLVRB P13489;H0YCR7 Ribonuclease inhibitor RNH P62266;D6RD47 40S ribosomal protein S23 RPS Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5- Serrate RNA effector molecule homolog SRRT ;Q9BXP5;H7C3A 1 Q6AI08;A0A087W XZ7;K7EIX2 HEAT repeat-containing protein 6 HEATR Q8N1G4 Leucine-rich repeat-containing protein 47 LRRC A0A096LNN4;Q9 NNW7-3;E7ENA2;Q9NN W7-2;D3YTF8;D3YTF 9;Q9NNW7;Q9NN W7-4;A0A096LPK7 Thioredoxin reductase 2, TXNRD Q15008;Q ;Q ;Q S proteasome non-atpase regulatory subunit 6 PSMD Q ;Q00341;A0A024 R4E5;H0Y394;H7 C0A4 Q8WVC2;P63220; Q9BYK1 Vigilin HDLBP S ribosomal protein S21 RPS S87

88 P ;P14324;A0A087 X1D8;A0A087WV Farnesyl pyrophosphate synthase FDPS N4 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 PRPF P ;P28838 Cytosol aminopeptidase LAP K7EJT5;K7EP65; K7EKS7;K7ELC4; K7EMH1;K7ERI7; P S ribosomal protein L22 RPL P ;P40616;F8VYN9 ;F8VP99;F8VP63; B4DZG7 O ;O00267;A0A0A0 MSV0 ADP-ribosylation factor-like protein 1 ARL Transcription elongation factor SPT5 SUPT5H P S ribosomal protein L34 RPL P49006 MARCKS-related protein MARCKSL P23396;P ;E9PL09;E9PPU 1;F2Z2S8;H0YCJ7 ;H0YEU2 Q9Y262;B0QY89; Q9Y262-2;B0QY90 Q9BWD1;Q9BWD 1-2 O ;O00571;O ;O15523 P23528;E9PK25; G3V1A4;E9PP50; E9PQB7;E9PLJ3; E9PS23 40S ribosomal protein S3 RPS Eukaryotic translation initiation factor 3 subunit L EIF3L Acetyl-CoA acetyltransferase, cytosolic ACAT ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y DDX3X;DDX3 Y Cofilin-1 CFL P ;P54886 Delta-1-pyrroline-5-carboxylate synthase;glutamate 5- kinase;gamma-glutamyl phosphate reductase ALDH18A A6NKB8;Q9H4A4; A0A087WU27 Q9Y230;Q9Y230-2 Q9NY33-4;Q9NY33;G3V1D 3;G3V180;E9PQ1 4 Q13228;Q ;Q ;A6PVX1;Q Aminopeptidase B RNPEP RuvB-like 2 RUVBL Dipeptidyl peptidase 3 DPP Selenium-binding protein 1 SELENBP P S ribosomal protein S25 RPS Q5JP53;P07437;Q 5ST81 Q ;Q99832;Q ;Q Tubulin beta chain TUBB T-complex protein 1 subunit eta CCT Q9UMS4;F5GY56 Pre-mRNA-processing factor 19 PRPF P ;P55060;P Exportin-2 CSE1L O15144 Actin-related protein 2/3 complex subunit 2 AR P ;Q32Q12;P22392 ;J3KPD9;E7ERL0; E5RHP0 Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase NME2;NME1- NME2;NME S88

89 A0A075B730;A0A 087X1U6;P58107 Epiplakin EPPK P54136;P Arginine--tRNA ligase, cytoplasmic RARS P60842;J3KTB5;J 3KT12;P ;J3QS69;J3QR64 ;J3QL43;J3QLN6; J3KS25;J3QKZ9;E 7EQG2;Q14240;Q Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II EIF4A1;EIF4A Q9H993;F5GZY1 UPF0364 protein C6orf211 C6orf Q9H6T0-2;Q9H6T0;H0YBR 2;H0YBB3;Q6NX G1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 Epithelial splicing regulatory protein 2;Epithelial splicing regulatory protein 1 ESRP2;ESRP Q13162;H7C3T4 Peroxiredoxin-4 PRDX P62280;M0QZC5 40S ribosomal protein S11 RPS Q9H845;H0Y8Z9 Acyl-CoA dehydrogenase family member 9, ACAD P50990;P ;P T-complex protein 1 subunit theta CCT P S ribosomal protein S12 RPS P50402;Q5HY57 Emerin EMD P31150 Rab GDP dissociation inhibitor alpha GDI O95292 P39023;G5E9G0; B5MCW2;H7C422 ;H7C3M2 P04075;J3KPS3;H 3BQN4;P ;H3BPS8;H3BUH 7;H3BR04;H3BM Q8 O ;O75947;F5H608 Vesicle-associated membrane protein-associated protein B/C VAPB S ribosomal protein L3 RPL Fructose-bisphosphate aldolase A;Fructosebisphosphate aldolase ALDOA ATP synthase subunit d, ATP5H P62241;Q5JR95 40S ribosomal protein S8 RPS P ;P35606 Coatomer subunit beta COPB J3KTF8;P52565;J 3QQX2;J3KRE2;P ;J3KRY1 Q ;Q ;A6PVN5;Q1525 7;F6WIT2;Q68CR 8;A6PVN6;Q5T94 9;Q5T948;A6PVN 9;Q Rho GDP-dissociation inhibitor 1 ARHGDIA Serine/threonine-protein phosphatase 2A activator PPP2R4;DKF Zp781M #VALUE! Fatty acid synthase;[acyl-carrier-protein] S- acetyltransferase;[acyl-carrier-protein] S- malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3- hydroxyacyl-[acyl-carrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl-[acyl-carrierprotein] hydrolase FASN O15355 Protein phosphatase 1G PPM1G P63244;J3KPE3;D 6RHH4;D6R9Z1;H 0Y8W2;D6R9L0;D 6RFX4;H0YAF8;H 0YAM7;D6RAC2; D6REE5 Guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L S89

90 P50395;P ;Q5SX87 P ;P09497;H0Y9Q6 Rab GDP dissociation inhibitor beta GDI Clathrin light chain B CLTB P ;P protein sigma SFN C9J0J7;P ;G5E9Q6;C9J71 2;C9JQ45;P35080 Q16186;A0A087W X59 P61088;F8VZ29;F 8VSD4;F8VV71;Q 5JXB2 Profilin-2;Profilin PFN Proteasomal ubiquitin receptor ADRM1 ADRM Ubiquitin-conjugating enzyme E2 N;Putative ubiquitinconjugating enzyme E2 N-like UBE2N;UBE2 NL Q9Y678 Coatomer subunit gamma-1 COPG P ;P ;P ;P Ribosomal protein S6 kinase beta-1 RPS6KB ;P23443 Q9BRA2;I3L0K2;I 3L3M7;I3L2R6 Thioredoxin domain-containing protein 17 TXNDC P27348;E9PG protein theta YWHAQ Q ;Q14318;A0A0A0 MTJ1;Q P68371;P04350 P60866;P ;E5RJX2;E5RIP1 O00148;O ;K7EQN7;B1Q2N 1 P62258;P ;B4DJF2;I3L3T1 P68363;P ;P ;P68366 B5MD17;J3KS05; P83916;C9JWS9; K7ELA4 P46781;B5MCT8; C9JM19 P ;P12814;P ;P ;H9KV75 Peptidyl-prolyl cis-trans isomerase FKBP8 FKBP Tubulin beta-4b chain;tubulin beta-4a chain TUBB4B;TUB B4A S ribosomal protein S20 RPS ATP-dependent RNA helicase DDX39A DDX39A;DDX protein epsilon YWHAE Tubulin alpha-1b chain;tubulin alpha-4a chain TUBA1B;TUB A4A Chromobox protein homolog 1 CBX S ribosomal protein S9 RPS Alpha-actinin-1 ACTN P10644;K7EM13; P camp-dependent protein kinase type I-alpha regulatory subunit;camp-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed PRKAR1A Q9UJW0;Q9UJW0-3;Q9UJW0-2 P62249;M0R210; M0R3H0;A0A087 WZ27;Q6IPX4 Dynactin subunit 4 DCTN S ribosomal protein S16 RPS P S ribosomal protein S18 RPS P ;P ;H0YCK3;P Double-stranded RNA-specific adenosine deaminase ADAR ;P55265;P F8W7C6;A0A087 WV22;X1WI28;P2 7635;H7C123;H7 C2C5 60S ribosomal protein L10 RPL O00232;O S proteasome non-atpase regulatory subunit 12 PSMD S90

91 P61247;D6RG13; D6RAT0;D6RB09; H0Y9Y4;E9PFI5;D 6R9B6;H0Y8L7 40S ribosomal protein S3a RPS3A Q14258 E3 ubiquitin/isg15 ligase TRIM25 TRIM P26641;P Elongation factor 1-gamma EEF1G P ;P08559;P ;P Pyruvate dehydrogenase E1 component subunit alpha, somatic form, PDHA P13639 Elongation factor 2 EEF Q8WUY1;H0YAR9 Protein THEM6 THEM A0A087X142;Q ;A6NMH6;A6NF Q9;Q ;F8W8I8;Q92599 ;Q Septin-8 SEPT Q96PK6 RNA-binding protein 14 RBM P ;P ;P15170;H3BR35 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT Q15393 Splicing factor 3B subunit 3 SF3B Q ;Q16555 Dihydropyrimidinase-related protein 2 DPYSL P00367;P ;P49448;P B9A041;P ;P40925;P ;B8ZZ51;C9JF79 P ;P ;P ;P ;P00390 P63104;E7EX29;B 0AZS6;P ;B7Z2E6;H0YB8 0;E7ESK7 Glutamate dehydrogenase 1, ;Glutamate dehydrogenase 2, Malate dehydrogenase, cytoplasmic;malate dehydrogenase GLUD1;GLUD MDH Glutathione reductase, GSR protein zeta/delta YWHAZ Q9Y676 28S ribosomal protein S18b, MRPS18B P17931;G3V3R6 Galectin-3 LGALS Q9UBV8 Peflin PEF H7C0R3;P ;P47897 Glutamine--tRNA ligase QARS P49755;G3V2K7 Transmembrane emp24 domain-containing protein 10 TMED Q13148;A0A087W X29;B1AKP7;Q ;G3V162;A0A087 X260;A0A087WY Y0;A0A087WW61; TAR DNA-binding protein 43 TARDBP A0A087WX67;A0 A087WXV3;A0A0 87WXQ5;K7EJM5; A0A087WV68;K7 EN94 P17858;P phosphofructokinase, liver type PFKL O95833;Q5SQ17 Chloride intracellular channel protein 3 CLIC Q8WUM4;Q8WU M4-2 Programmed cell death 6-interacting protein PDCD6IP P09382 Galectin-1 LGALS P ;P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP Q9Y266;A0A0A0 MSS4;A0A0A0MS Nuclear migration protein nudc NUDC U9 P11216 Glycogen phosphorylase, brain form PYGB S91

92 O43707;O ;O ;F5GXS2 P47985;P0C7P4 Alpha-actinin-4 ACTN Cytochrome b-c1 complex subunit Rieske, ;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1;UQ CRFS1P P S ribosomal protein S4, X isoform RPS4X O75396 Vesicle-trafficking protein SEC22b SEC22B P ;P S protease regulatory subunit 4 PSMC Q14344;Q Guanine nucleotide-binding protein subunit alpha-13 GNA P42224;P ;J3KPM9 Signal transducer and activator of transcription 1- alpha/beta STAT P00918 Carbonic anhydrase 2 CA P36578;H3BM89 60S ribosomal protein L4 RPL P11413;P ;P ;E7EUI8;E9PD92 ;E7EM57 E9PKZ0;P62917; G3V1A1;E9PKU4 Glucose-6-phosphate 1-dehydrogenase G6PD S ribosomal protein L8 RPL Q9UBM7;E9PM00 7-dehydrocholesterol reductase DHCR Q5BJF2;Q86XC5; J3KT68;J3KTD1 Transmembrane protein 97 TMEM M0R261;O phosphogluconolactonase PGLS P62140;E7ETD8 Serine/threonine-protein phosphatase PP1-beta catalytic subunit;serine/threonine-protein phosphatase PPP1CB Q9UHB9-4;Q9UHB9-2;Q9UHB9;Q9UH Signal recognition particle subunit SRP68 SRP B9-3 O00299 Chloride intracellular channel protein 1 CLIC I3L3P7;P S ribosomal protein S15a RPS15A P42677;Q5T4L4;Q 71UM5;H0YMV8 40S ribosomal protein S27;40S ribosomal protein S27- like RPS27;RPS27 L P61006;P Ras-related protein Rab-8A RAB8A P62854;Q5JNZ5 P04843;B7Z4L4 E9PK01;P29692;A 0A087X1X7;P ;E9PRY8;E9PM W7;E9PIZ1;E9PP R1;E9PL12;E9PQ 49;E9PI39;H0YCK 7;P ;E9PN91;E9PL71 ;E9PQZ1;P S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPS26;RPS26 P RPN Elongation factor 1-delta EEF1D Q7KZF4 Staphylococcal nuclease domain-containing protein 1 SND P60981;P ;F6RFD5 Destrin DSTN P62937;P ;F8WE65;C9J5S 7 Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cistrans isomerase A, N-terminally processed;peptidyl-prolyl cis-trans isomerase PPIA P ;P protein beta/alpha; protein beta/alpha, N- terminally processed YWHAB Q04917;A2IDB protein eta YWHAH S92

93 O95994;B5MC07; C9J3E2;H7C3Z9 P84077;P61204;F 5H423;F5H0C7 K7EJC1;K7EJR3; R4GMR5;P48556 Q9NZB2;Q9NZB2-6;Q9NZB2-4 P19105;O14950;J 3QRS3 Q14247;Q ;Q ;H7C314 Anterior gradient protein 2 homolog AGR ADP-ribosylation factor 1;ADP-ribosylation factor 3 ARF1;ARF S proteasome non-atpase regulatory subunit 8 PSMD Constitutive coactivator of PPAR-gamma-like protein 1 FAM120A Myosin regulatory light chain 12A;Myosin regulatory light chain 12B MYL12A;MYL 12B Src substrate cortactin CTTN O95881 Thioredoxin domain-containing protein 12 TXNDC Q96AG4 Leucine-rich repeat-containing protein 59 LRRC O43776 Asparagine--tRNA ligase, cytoplasmic NARS P09467 Fructose-1,6-bisphosphatase 1 FBP Q ;Q ;Q13085;Q13085 Acetyl-CoA carboxylase 1;Biotin carboxylase ACACA P ;P35606 Coatomer subunit beta COPB P51149;C9J8S3;C 9IZZ0;C9J592;C9J 4V0 Ras-related protein Rab-7a RAB7A Q96HS1-2;Q96HS1 Serine/threonine-protein phosphatase PGAM5, PGAM P S ribosomal protein L12 RPL G3V4C6;Q9Y224; H0YJB9 P62829;C9JD32;J 3KT29;J3KTJ3;B9 ZVP7 Q ;Q ;Q15366;Q ;H3BRU6;Q ;F8VZX2;B4DXP 5;Q ;Q Q9BWF3;E9PB51; Q9BWF3-4;Q9BQ04;Q9BW F3-3;D6R9K7;J3QRR 5;Q9BWF3-2;E9PLB0;E9PM6 1;U3KQD5 Q9NZM1-2;Q9NZM1-6;Q9NZM1;Q9NZ M1-3;H0YD14;Q9NZM 1-5 P21291;E9PS42;E 9PND2;E9PP21 UPF0568 protein C14orf166 C14orf S ribosomal protein L23 RPL Poly(rC)-binding protein 2 BP RNA-binding protein 4;RNA-binding protein 4B RBM4;RBM4B Myoferlin MYOF Cysteine and glycine-rich protein 1 CSRP P S ribosomal protein S28 RPS P31930 Cytochrome b-c1 complex subunit 1, UQCRC E9Y5;Q ;Q02880 P52943;H0YHD8; H0YFA4;P DNA topoisomerase 2;DNA topoisomerase 2-beta TOP2B Cysteine-rich protein 2 CRIP S93

94 O43399;O ;A0A087WYR3;O ;O ;O ;O ;O P51572;P ;C9JSP1;C9JQ7 5;C9J0M4 P06748;P ;P J3QQM1;P ;P62195;J3QLH6 ;J3KRP2;J3QSA9 Q6P1M3-2;J3QRV5;Q6P1M 3 Q ;Q14103;H0Y8G 5;H0YA96;D6RAF 8;Q ;Q ;D6RF44 Q13155;A8MU58; F8W950 Tumor protein D54 TPD52L B-cell receptor-associated protein 31 BCAP Nucleophosmin NPM S protease regulatory subunit 8 PSMC Lethal(2) giant larvae protein homolog 2 LLGL Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Aminoacyl trna synthase complex-interacting multifunctional protein 2 AIMP P04080 Cystatin-B CSTB Q9UHG3;Q9UHG 3-2;F8W8W4 P ;P52209;K7EM49 ;K7EMN2;K7EPF6 Prenylcysteine oxidase 1 YOX phosphogluconate dehydrogenase, decarboxylating PGD O ;O ;O Heterogeneous nuclear ribonucleoprotein Q SYNCRIP ;O60506;B7Z645 ;O Q13151 Heterogeneous nuclear ribonucleoprotein A0 HNRNPA P ;P ;P ;P09496;F8WF69 Clathrin light chain A CLTA O75874;C9J4N6 Isocitrate dehydrogenase [NADP] cytoplasmic IDH H0YMZ1;H0YL69; P25789;H0YLS6; H0YLC2;H0YMI6; H0YMA1;H0YN18 Q9UHD8-7;Q9UHD8-2;Q9UHD8-5;Q9UHD8;Q9UH D8-3;Q9UHD8-4;Q9UHD8-9;Q9UHD8-8;K7EL40 Q ;Q16698;E5RJG 7;E5RFV2;E5RJD 2 P62333;A0A087X 2I1;H0YJC0 Proteasome subunit alpha type;proteasome subunit alpha type-4 PSMA Septin-9 SEPT ,4-dienoyl-CoA reductase, DECR S protease regulatory subunit 10B PSMC Q9NSE4 Isoleucine--tRNA ligase, IARS Q9NTK5;J3KQ32; Q9NTK5-2 Obg-like ATPase 1 OLA Q05639 Elongation factor 1-alpha 2 EEF1A P14866;P ;M0QXS5 Heterogeneous nuclear ribonucleoprotein L HNRNPL Q96FQ6 Protein S100-A16 S100A S94

95 P07237;F5H8J2;H 7BZ94;H0Y3Z3 E9PLL6;P46776;E 9PJD9 P05141 Protein disulfide-isomerase P4HB S ribosomal protein L27a RPL27A ADP/ATP translocase 2;ADP/ATP translocase 2, N- terminally processed SLC25A Q13185;S4R2Y4 Chromobox protein homolog 3 CBX Q9H3N1 Thioredoxin-related transmembrane protein 1 TMX P53992;G5EA31 Protein transport protein Sec24C SEC24C P45973 Chromobox protein homolog 5 CBX Q ;Q ;Q AP-1 complex subunit beta-1 AP1B ;Q10567;C9J1E7 P21266;A0A0A0M TN3 Glutathione S-transferase Mu 3 GSTM Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed FKBP Q5QNZ2;P24539 ATP synthase subunit b, ATP5F J3QR09;J3KTE4; P84098;J3QL15 Q9BUJ2-4;A0A0A0MRA5;B 7Z4B8;Q9BUJ2-2;Q9BUJ2;M0R3F 1;Q9BUJ2-3;M0QYZ0 Q ;Q15084;Q ;Q ;Q P62277;J3KMX5; E9PS50 F5GYN4;Q96FW1 ;J3KR44;F5H6Q1; F5GYJ8;F5H3F0; Q96FW1-2 Ribosomal protein L19;60S ribosomal protein L19 RPL Heterogeneous nuclear ribonucleoprotein U-like protein 1 HNRNPUL Protein disulfide-isomerase A6 PDIA S ribosomal protein S13 RPS Ubiquitin thioesterase OTUB1 OTUB Q13404;Q ;Q ;Q ;I3L0A0;Q ;G3V2F7;Q15819 ;E5RIF1;D6RG00; Q ;A0A0A0MSL3;G 3V113;H0YBX6 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitinconjugating enzyme E2 variant 2 UBE2V1;TME M189;UBE2V P24468;P ;P ;F1DAL9;P10589 COUP transcription factor 2;COUP transcription factor 1 NR2F2;NR2F P62424;Q5T8U3 60S ribosomal protein L7a RPL7A P56545;Q5SQP8; P P13798;C9JIF9;H 7C393;H7C1U0 C-terminal-binding protein 2 CTBP Acylamino-acid-releasing enzyme APEH O75083;D6RD66 WD repeat-containing protein 1 WDR P35998;P S protease regulatory subunit 7 PSMC Q9UQ35;Q9UQ35-2 Serine/arginine repetitive matrix protein 2 SRRM U3KQE2;K7EIV0; A0A075B7C0;P04 632;U3KPR7;K7E Calpain small subunit 1 CAPNS KD8;K7ELJ7;K7E M73 P46940;H0YLE8 Ras GTPase-activating-like protein IQGAP1 IQGAP O14980 Exportin-1 XPO S95

96 Q8N163-2;Q8N163;G3V11 9;H0YB24 Q ;O95086;H3BPM 8;Q2TA70;B4DFF 3;Q ;Q ;Q ;Q13286;O95090 ;Q9UBD8;H3BQ48 ;Q ;B4DMY6;Q Q01081;Q ;Q DBIRD complex subunit KIAA1967 KIAA Battenin CLN Splicing factor U2AF 35 kda subunit U2AF P36957;P Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, DLST Q ;Q00610;A0A087 WVQ6 J3QT28;O ;O43684 Clathrin heavy chain 1 CLTC Mitotic checkpoint protein BUB3 BUB B4DJV2;O75390 Citrate synthase;citrate synthase, CS A0A075B6F6;Q8T CT9-5;Q8TCT9;Q8TCT 9-4;Q8TCT9-2 J3KR24;A0A0A0M SX9;P41252 Minor histocompatibility antigen H13 HM Isoleucine--tRNA ligase, cytoplasmic IARS H7C3I1;F6VDH7; Q3KNR6;Q8IZP2; A0A087X1H6;P50 502;Q8NFI4 P11142;E9PKE3;P ;E9PN89;E9PNE 6 P ;P42126;Q96DC 0;H3BS70 Q ;Q92688 Putative protein FAM10A4;Hsc70-interacting protein;putative protein FAM10A5 ST13;ST13P4; ST13P Heat shock cognate 71 kda protein HSPA Enoyl-CoA delta isomerase 1, ECI1;DCI Acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B P ;P49321;P ;H0YDS9;Q5T62 4;P Nuclear autoantigenic sperm protein NASP ;E9PRH9;H0YF3 3 O94776 Metastasis-associated protein MTA2 MTA P62136;P ;P ;E9PMD7 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;serine/threonine-protein phosphatase PPP1CA P07900;P Heat shock protein HSP 90-alpha HSP90AA P08758;D6RBE9; D6RBL5;E9PHT9 F8W1R7;P ;P60660;J3KND3 ;G8JLA2;G3V1V0; B7Z6Z4;F8VPF3; G3V1Y7;F8VZU9; F8W180 Annexin A5;Annexin ANXA Myosin light polypeptide 6 MYL S96

97 O ;O75534;O ;O ;E9PLT0 C9J0K6;P ;P ;P30626 P02792;A0A087X 1B9 Cold shock domain-containing protein E1 CSDE Sorcin SRI Ferritin light chain FTL P07737;K7EJ44 Profilin-1 PFN P07384 Calpain-1 catalytic subunit CAPN P54920;M0R0Y2; M0R2M1;M0R213 P00338;P ;P ;P ;P ;F5GXY2;F5GYU 2 P35241;P ;P B4DUR8;P ;P49368 Alpha-soluble NSF attachment protein NAPA L-lactate dehydrogenase A chain LDHA Radixin RDX T-complex protein 1 subunit gamma CCT Q9Y6C9 Mitochondrial carrier homolog 2 MTCH P08107;P ;V9GZ37 P ;P27816;E7EVA0 ;P ;P ;H0Y2V1;F8W9U 4;H7C4C5;B5ME G9;P Heat shock 70 kda protein 1A/1B HSPA1A Microtubule-associated protein 4;Microtubule-associated protein MAP P08238 Heat shock protein HSP 90-beta HSP90AB P13667 Protein disulfide-isomerase A4 PDIA Q9NR45 Sialic acid synthase NANS P41240;H3BUM9 Tyrosine-protein kinase CSK CSK P11586;F5H2F4 MTHFD P12956;B1AHC9; P X-ray repair cross-complementing protein 6 XRCC Q9BS26 Endoplasmic reticulum resident protein 44 ERP B4DY09;Q12905 Interleukin enhancer-binding factor 2 ILF C-1-tetrahydrofolate synthase, cytoplasmic;methylenetetrahydrofolate dehydrogenase;methenyltetrahydrofolate cyclohydrolase;formyltetrahydrofolate synthetase;c-1- tetrahydrofolate synthase, cytoplasmic, N-terminally processed P14868;P ;C9J7S3;C9JLC1 E9PF16;Q96CM8-3;Q96CM8;Q96C M8-2;Q96CM8-4 M0R3D6;M0R1A7; M0R117;Q02543; M0R0P7 K7ENG2;P ;P26368 A0A087WXM6;J3 QQT2;J3KRX5;P1 8621;P ;J3KRB3;A0A087 WWH0;J3QS96;P ;J3QLC8;A0A0A 0MRF8;A0A087W Y81 Aspartate--tRNA ligase, cytoplasmic DARS Acyl-CoA synthetase family member 2, ACSF S ribosomal protein L18a RPL18A Splicing factor U2AF 65 kda subunit U2AF S ribosomal protein L17 RPL S97

98 F5H1Z6;F5H8H3; Q9Y365;A0A087 WXR2;F5H8G1;F5 GY11;F5GWK5;F5 H5A8;H0YGN8;F5 H3G8;F5H0V7;H0 YH17;H0YFF3 P80404;H3BRN4; H3BNQ7 P46779;P ;P ;H0YKD8;P ;P ;H0YLP6;H0YMF 4 A0A087X2D0;P ;P84103 TP-like protein STARD aminobutyrate aminotransferase, ABAT S ribosomal protein L28 RPL Serine/arginine-rich splicing factor 3 SRSF P62888;E5RI99 60S ribosomal protein L30 RPL G5E972;P42167;P Lamina-associated polypeptide 2, isoforms 2;H0YJH7;P42167 beta/gamma;thymopoietin;thymopentin TMPO P23526;P Adenosylhomocysteinase AHCY Q ;Q06210 H0YEN5;P15880; E9PQD7;E9PMM9 H3BRG4;P22695; H3BSJ9 Glutamine--fructose-6-phosphate [isomerizing] 1 aminotransferase GFPT S ribosomal protein S2 RPS Cytochrome b-c1 complex subunit 2, UQCRC P ;P20073 Annexin A7 ANXA P46977;P P31948;P ;P P05388;F8VU65;P ;F8VWS0;F8VPE 8;G3V210;F8VQY 6;F8VRK7;F8VW2 1;Q8NHW5;F8VS 58;F8VZS0;F8VW V4 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A Stress-induced-phosphoprotein 1 STIP S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like RPLP0;RPLP0 P P78527;P DNA-dependent protein kinase catalytic subunit PRKDC Q S ribosomal protein L6 RPL P46777;Q5T7N0 60S ribosomal protein L5 RPL P08574 Cytochrome c1, heme protein, CYC Q14554 Protein disulfide-isomerase A5 PDIA P ;P07305 Histone H1.0;Histone H1.0, N-terminally processed H1F P41091;Q2VIR3;Q 2VIR3-2;F8W810 Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein EIF2S3;EIF2S 3L P ;P56159 GDNF family receptor alpha-1 GFRA P61981 O14818;O ;H0Y586;Q8TAA 3-2;Q8TAA3-5;Q8TAA3 P22626;P ;A0A087WUI protein gamma; protein gamma, N- terminally processed Proteasome subunit alpha type-7;proteasome subunit alpha type-7-like YWHAG PSMA7;PSMA Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B S98

99 Q5VTE0;P68104; P ;A0A087WVQ9;A 0A087WV01 Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EEF1A1P5;EE F1A Q9H0D6-2;Q9H0D6 5-3 exoribonuclease 2 XRN P19338;H7BY16 Nucleolin NCL E5RIW3;O75347; E5RJD8;O ;E5RHG6 M0R389;Q15102 Tubulin-specific chaperone A TBCA Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B P30086 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide PEBP Q9Y277;Q9Y277-2;E5RJN6;E5RHZ 6 P31943;G8JLB6;E 9Y7;D6RBM0; H0YB39;D6RIT2; D6RIU0 Voltage-dependent anion-selective channel protein 3 VDAC Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N- terminally processed HNRNPH O43747;O AP-1 complex subunit gamma-1 AP1G P ;P04844;Q5JYR4 ;Q5JYR7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN P22234;P ;D6RF62;E9PBS 1 Multifunctional protein ADE2;Phosphoribosylaminoimidazolesuccinocarboxamide synthase;phosphoribosylaminoimidazole carboxylase PAICS Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H Q ;F1T0B3;A0A087 X2G1;Q92499;Q P02545;P ;P ;P ;P Q16822;B4DW73; H0YML5;H0YM31; Q ;A0A0A0MS74 P ;P52272;A0A087 X0X3 Q9Y383-3;Q9Y383-2;Q9Y383;Q96HJ 9-2;B8ZZ10;A8MYV 2;Q9NQ29-2;Q9NQ29-3;Q9NQ29 ATP-dependent RNA helicase DDX1 DDX Prelamin-A/C;Lamin-A/C LMNA Phosphoenolpyruvate carboxykinase [GTP], K Heterogeneous nuclear ribonucleoprotein M HNRNPM Putative RNA-binding protein Luc7-like 2;Putative RNAbinding protein Luc7-like 1 LUC7L2;LUC7 L P53007 Tricarboxylate transport protein, SLC25A Q7L576;E7EW33; H7C229;E7EVJ5; Q96F07-2;Q96F07;Q7L576-2 Q ;Q12931;I3L0K7 Cytoplasmic FMR1-interacting protein 1;Cytoplasmic FMR1-interacting protein 2 CYFIP1;CYFI P Heat shock protein 75 kda, TRAP S99

100 C9JW69;P18754; P ;C9JRH2;C9JMJ Regulator of chromosome condensation RCC ;C9J3R0;C9JQZ 4 Q13509;Q Tubulin beta-3 chain TUBB P35914 Hydroxymethylglutaryl-CoA lyase, HMGCL K7EK07;Q71DI3; Q16695;P84243;P 68431;K7EMV3;B 4DEB1;K7ES00;Q 6NXT2 Histone H3;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1;Histone H3.3C H3F3B;HIST2 H3A;HIST3H3; H3F3A;HIST1 H3A;H3F3C Q Plectin PLEC P60468 Protein transport protein Sec61 subunit beta SEC61B Q96DG6 Carboxymethylenebutenolidase homolog CMBL Q01813;Q phosphofructokinase type C PFKP P10620;F5H7F6;F 5H6X2;P ;F5H760 Microsomal glutathione S-transferase 1 MGST P18669 Phosphoglycerate mutase 1 PGAM A0A087WTT1;P ;P11940;E7EQV3 ;E7ERJ7;H0YAR2; Q9H361 Polyadenylate-binding protein 1;Polyadenylate-binding protein 3 PAB1;PAB Q ;Q16851;A0A087 WYS1;E7EUC7 P ;P31942;P Q13838;Q ;Q5STU3;F6WLT 2;F6S4E6;A0A0A0 MT12;F6TRA5 UTP--glucose-1-phosphate uridylyltransferase UGP Heterogeneous nuclear ribonucleoprotein H3 HNRNPH Spliceosome RNA helicase DDX39B DDX39B P00492 Hypoxanthine-guanine phosphoribosyltransferase HPRT P16401 Histone H1.5 HIST1H1B P ;P31153 S-adenosylmethionine synthase isoform type-2 MAT2A Q9Y5M8;H7C4H2 Signal recognition particle receptor subunit beta SRPRB P ;P31939 Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;imp cyclohydrolase S100 ATIC P30084 Enoyl-CoA hydratase, ECHS P24534 Elongation factor 1-beta EEF1B Q9NQR4;H7C579 Omega-amidase NIT2 NIT P ;P ;P ;P Non-specific lipid-transfer protein SCP ;P ;P22307;H0YF61 J3KS22;J3QS36; Q7Z4W1;J3QS45; J3KRZ4;J3KSZ5;J 3QL34 L-xylulose reductase DCXR Q14974;J3KTM9; Q Importin subunit beta-1 KPNB Q9NZT2-2;Q9NZT2;A0A0A 0MRN5;A0A087X Opioid growth factor receptor OGFR P61026 Ras-related protein Rab-10 RAB P S ribosomal protein L10a RPL10A

101 Q8IY81 pre-rrna processing protein FTSJ3 FTSJ P ;P38606 V-type proton ATPase catalytic subunit A ATP6V1A P23284 Peptidyl-prolyl cis-trans isomerase B PPIB O00567;H0Y653; H0YDU4 F5H6I7;Q6DD88;F 5GWF8 P62879;C9JIS1;C 9JXA5;E7EP32;C 9JZN1;Q9HAV0 P ;P62995;H7C2L4 ;H7BXF3 Nucleolar protein 56 NOP Atlastin-3 ATL Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;guanine nucleotide-binding protein subunit beta-4 GNB2;GNB Transformer-2 protein homolog beta TRA2B P27797;K7EJB9 Calreticulin CALR P ;H3BMH2;Q ;H3BSC1;P6249 1;Q15907 Ras-related protein Rab-11A;Ras-related protein Rab- 11B RAB11A;RAB 11B P18031;B4DSN5 Tyrosine-protein phosphatase non-receptor type 1;Tyrosine-protein phosphatase non-receptor type PTPN Q92522 Histone H1x H1FX P ;P39656;P ;U3KQ84 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit DDOST P ;P22314 Ubiquitin-like modifier-activating enzyme 1 UBA Q9BSJ8;Q9BSJ8-2 Extended synaptotagmin-1 ESYT A0A0A0MR02;P ;P45880;P Voltage-dependent anion-selective channel protein 2 VDAC ;Q5JSD2;Q5JSD 1 Q9UL46;A0A087X 1Z3;H0YM70 Proteasome activator complex subunit 2 PSME Q12907;D6RBV2; D6RIU4;D6RDX1 Vesicular integral-membrane protein VIP36 LMAN P ;P67775;P62714; E7ESG8 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;serine/threonine-protein phosphatase 2A catalytic subunit beta isoform;serine/threonine-protein phosphatase PPP2CA;PPP 2CB P ;A0A087WWU8; Q5VU59;P ;P ;P ;P ;Q5VU61;J3KN6 7;P06753;P P ;P17844;J3KTA4 Q9NX63;C9JRZ6; F8WAR4 Tropomyosin alpha-3 chain TPM Probable ATP-dependent RNA helicase DDX5 DDX Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, CHCHD P63261;P60709 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;actin, cytoplasmic 1;Actin, cytoplasmic 1, N- terminally processed ACTG1;ACTB P ;H3BQF1;H3BQB 1;P07741;H3BSW 3;H3BQZ9 Adenine phosphoribosyltransferase APRT S101

102 Q ;Q02252 C9J9K3;P08865;A 6NE09 Q5JR08;P08134;E 9PQH6;P61586;Q 5JR07;C9JNR4;C 9JX21;Q5JR05 P63092;P ;Q5JWF2;P ;P ;Q5JWF2-2 Methylmalonate-semialdehyde [acylating], 40S ribosomal protein SA dehydrogenase Rho-related GTP-binding protein RhoC;Transforming protein RhoA Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas ALDH6A RPSA;RPSAP RHOC;RHOA GNAS G3V1B3;M0R181; P46778 P30046;J3KQ18;P ;A6NHG4;B5MC 82 O60701;O ;O A0A087X054;Q9Y 4L1;Q9Y4L1-2;E9PJ21;A0A087 WWI4;K7EQK2 Q ;Q02218;E9PDF 2;E9R7;E9PFG 7 60S ribosomal protein L21 RPL D-dopachrome decarboxylase;d-dopachrome decarboxylase-like protein DDT;DDTL UDP-glucose 6-dehydrogenase UGDH Hypoxia up-regulated protein 1 HYOU oxoglutarate dehydrogenase, OGDH E9PLK3;P55786;P ;A6NEC2 Puromycin-sensitive aminopeptidase;puromycinsensitive aminopeptidase-like protein NPEPPS;NPE PPSL P kda glucose-regulated protein HSPA Q ;Q13200;Q ;H7C1H2 P68032;P63267;P 62736;P68133;Q5 T8M8;A6NL76;F8 WB63;B8ZZJ2;C9 JFL5;F6UVQ4;F6 QUT6 Q06830;A0A0A0M SI0 E952;Q16576; Q Q9BPW8;H7C2U6 ;C9JDV8 Q13011;M0R248 P09429;Q5T7C4; Q5T7C6 E9PKG1;Q ;Q ;Q ;Q99873;H7C2I1; E9PIX6;E9PQ98;A 0A087X1W2;E9P NR9;H0YDE4 26S proteasome non-atpase regulatory subunit 2 PSMD Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;actin, aortic smooth muscle;actin, alpha skeletal muscle ACTC1;ACTG 2;ACTA2;ACT A Peroxiredoxin-1 PRDX Histone-binding protein RBBP7 RBBP Protein NipSnap homolog 1 NIPSNAP Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, ECH High mobility group protein B1 HMGB Protein arginine N-methyltransferase 1 PRMT P14625 Endoplasmin HSP90B O15269 Serine palmitoyltransferase 1 SPTLC S102

103 O15231;O ;O ;O ;O ;H0Y704;O ;O ;O ;H7BZT5 P52597 Zinc finger protein 185 ZNF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N- terminally processed HNRNPF Q15365 Poly(rC)-binding protein 1 BP J3QLR8;Q9Y3D9 28S ribosomal protein S23, MRPS Q ;Q14152 Eukaryotic translation initiation factor 3 subunit A EIF3A Q96TA1-2;Q96TA1 Niban-like protein 1 FAM129B P ;P49915 GMP synthase [glutamine-hydrolyzing] GMPS Q ;Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU P61160;F5H6T1;P Q9P035;H3BPZ1; H3BS72;Q9P035-2 P13693;Q5W0H4; P ;J3KPG2;E9PJF7 Actin-related protein 2 ACTR Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 PTPLAD Translationally-controlled tumor protein TPT P27824;P ;P Calnexin CANX ;D6RGY2 P30040;F8VY02 Endoplasmic reticulum resident protein 29 ERP P27695;G3V5Q1; G3V3M6;G3V5D9; G3V3C7 Q07955;J3KTL2;Q ;Q ;J3KSR8 DNA-(apurinic or apyrimidinic site) lyase;dna-(apurinic or apyrimidinic site) lyase, APEX Serine/arginine-rich splicing factor 1 SRSF H0YDD4;P10515; E9PEJ4 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, DLAT Q08211 ATP-dependent RNA helicase A DHX P18124;A8MUD9 60S ribosomal protein L7 RPL Q ;Q13813;Q Spectrin alpha chain, non-erythrocytic 1 SPTAN P ;P55084;B5MD3 8;F5GZQ3;C9JEY 0;C9JE81 Trifunctional enzyme subunit beta, ;3- ketoacyl-coa thiolase HADHB O43772;C9JPE1 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A Q12906;Q ;Q ;Q ;Q ;Q ;Q Q ;Q ;Q ;Q01105;A0A087 X027;P0DME0 Interleukin enhancer-binding factor 3 ILF Protein SET SET P hydroxyisobutyrate dehydrogenase, HIBADH Q6NUK1-2;Q6NUK1 Calcium-binding carrier protein SCaMC-1 SLC25A S103

104 P ;P ;P General transcription factor II-I GTF2I ;P78347 P04792 Heat shock protein beta-1 HSPB P ;P34897;P ;H0YIZ0;G3V2Y4 Serine hydroxymethyltransferase, ;Serine hydroxymethyltransferase SHMT P ;P50416 Carnitine O-palmitoyltransferase 1, liver isoform CPT1A P ;P21333;Q5HY54 ;Q60FE5;A0A087 WWY3 Filamin-A FLNA P49411 Elongation factor Tu, TUFM O ;O ;A0A087WUK2;O Heterogeneous nuclear ribonucleoprotein D-like HNRPDL P30041 Peroxiredoxin-6 PRDX Q ;Q00325;F8VVM 2 Phosphate carrier protein, SLC25A P ;P60174;P ;U3KPZ0 P06744;P ;A0A0A0MTS2;K 7EQ48 Triosephosphate isomerase TPI Glucose-6-phosphate isomerase GPI Q9BUH6 Uncharacterized protein C9orf142 C9orf P ;P ;P62834;P61224; F5H4H0;F5GYH7; F5H077;F5GWU8; F5H491;F5H0B7;F 5H500;F5H6R7;F5 H004;A0A075B6Q 0;F5GYB5;F5GX6 2;E7ESV4;F5H7Y 6;P ;A6NIZ1 O ;O95831;O P38919 O ;O14735;B3KY94 Q96N66;Q96N66-3;Q96N66-2 Ras-related protein Rap-1b;Ras-related protein Rap- 1A;Ras-related protein Rap-1b-like protein RAP1B;RAP1 A Apoptosis-inducing factor 1, AIFM Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed EIF4A CDP-diacylglycerol--inositol 3-phosphatidyltransferase CDIPT Lysophospholipid acyltransferase 7 MBOAT P26583;D6R9A6 High mobility group protein B2 HMGB Q86VP6;Q86VP6-2 Cullin-associated NEDD8-dissociated protein 1 CAND P04899;P ;P ;P Guanine nucleotide-binding protein G(i) subunit alpha- 3;P ;Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI2;GNAI ;P ;P63096 P23246;P Splicing factor, proline- and glutamine-rich SFPQ X6RFL8;P61106 Ras-related protein Rab-14 RAB P ;P62873;B1AKQ 8;F6UT28;F6X3N5 P63000;P ;P60763;P15153 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3;Ras-related C3 botulinum toxin substrate 2 GNB RAC1;RAC3;R AC S104

105 Q969X5-2;Q969X5 Q ;Q14980;Q ;Q ;A0A087WY61 Endoplasmic reticulum-golgi intermediate compartment protein 1 ERGIC Nuclear mitotic apparatus protein 1 NUMA P55072 Transitional endoplasmic reticulum ATPase VCP P61313;E7EQV9; E7ENU7;E7EX53 P ;P14314;K7ELL7 60S ribosomal protein L15;Ribosomal protein L15 RPL Glucosidase 2 subunit beta PRKCSH P30101 Protein disulfide-isomerase A3 PDIA Q ;Q13724;C9J8D4 P17987;E7EQR6; F5H282 Mannosyl-oligosaccharide glucosidase MOGS T-complex protein 1 subunit alpha TCP Q99436 Proteasome subunit beta type-7 PSMB P30153;C9J9C1;B 3KQV6 Serine/threonine-protein phosphatase 2A 65 kda regulatory subunit A alpha isoform PPP2R1A Q15181;Q5SQT6 Inorganic pyrophosphatase PPA Q86UY0;Q8NBS9; Q8NBS9-2 P ;P ;P19367;P P ;F8W6I7;P ;P09651;F8VTQ5 ;F8VZ49;Q32P51 F5H365;Q15436; Q Thioredoxin domain-containing protein 5 TXNDC Hexokinase-1 HK Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1-like 2 HNRNPA1;HN RNPA1L Protein transport protein Sec23A SEC23A P13010 X-ray repair cross-complementing protein 5 XRCC G3V1Q4;E7ES33; Q ;Q16181;E7EPK 1;H0Y3Y4 Q8TD06;B5MC62; H7C040 B4DLR8;P ;P ;P15559;H3BNV 2;H3BRK3 O ;O ;O75367;B4DJC3 P ;E7ENZ3;B7ZAR 1;E9A1;P48643 Septin-7 SEPT Anterior gradient protein 3 homolog AGR NAD(P)H dehydrogenase [quinone] 1 NQO Core histone macro-h2a.1;histone H2A H2AFY T-complex protein 1 subunit epsilon CCT P ;P48449;P Lanosterol synthase LSS P ;P68036;P Ubiquitin-conjugating enzyme E2 L3 UBE2L Q96HE7 ERO1-like protein alpha ERO1L B1AK87;P ;B1AK88;P47756 ;B1AK85 P ;P49902;Q5JUV4 Q9UJS0;Q9UJS0-2;O ;O75746 F-actin-capping protein subunit beta CAPZB Cytosolic purine 5-nucleotidase NT5C Calcium-binding carrier protein Aralar2;Calcium-binding carrier protein Aralar1 SLC25A13;SL C25A S105

106 Q13630;E9PKL9; E9PLH9;E9PP14 GDP-L-fucose synthase TSTA O14745;J3QRP6 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 SLC9A3R P67936;P ;K7ENT6 Tropomyosin alpha-4 chain TPM P51148;P ;K7ERI8;K7ERQ 8;F8VWU4;F8VVZ 0;F8VUA5;F8VVK 3;K7ENY4;P ;P20339 Ras-related protein Rab-5C;Ras-related protein Rab-5A RAB5C;RAB5 B;RAB5A Q13547;Q5TEE2 Histone deacetylase 1 HDAC P51991;P Heterogeneous nuclear ribonucleoprotein A3 HNRNPA P31949 Protein S100-A11 S100A P78371;P ;F5GWF6;F8VQ1 T-complex protein 1 subunit beta CCT P00505;P Aspartate aminotransferase, GOT Q96CW1-2;A0A087WY71;Q 96CW1;E9PFW3; C9JJ47;C9JTK4;C 9JGT8;C9JJD3;C9 JPV8 AP-2 complex subunit mu AP2M P ;P14678;A8MT02 ;P ;J3QLE5;P63162 ;P Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N SNRPB;SNRP N O75533 Splicing factor 3B subunit 1 SF3B Q9UKK9;A6NFX8; A6NCQ0;A6NJU6 ADP-sugar pyrophosphatase NUDT Q10713 Mitochondrial-processing peptidase subunit alpha PMA A0A087WU65;Q9 NRW7;Q9NRW7-2;Q5T4Q0 Q8N1F7;Q8N1F7-2;H3BVG0 Vacuolar protein sorting-associated protein 45 VPS Nuclear pore complex protein Nup93 NUP P07355;P ;H0YN42;H0YMD 0;H0YMU9;A6NM Y6;H0YM50;H0YK S4;H0YN28;H0YL 33;H0YNP5 Annexin A2;Annexin;Putative annexin A2-like protein ANXA2;ANXA 2P Q5TEC6 Histone H3 HIST2H3PS Q9NR46;B7ZC38; B7ZC39;Q9NR46-2;F8WFB9 Endophilin-B2 SH3GLB P52907 F-actin-capping protein subunit alpha-1 CAPZA P ;P40227 T-complex protein 1 subunit zeta CCT6A O95340;O P ;P62913;Q5VVC 8;Q5VVC9 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;adenylyl-sulfate kinase PAPSS S ribosomal protein L11 RPL Q15046;Q Lysine--tRNA ligase KARS S106

107 F8VY04;P ;P ;F8W1A4;P5481 9;G3V213;F8VZG 5;P ;P G3XAM7;P35221; P Adenylate kinase 2, ;Adenylate kinase 2,, N-terminally processed AK Catenin alpha-1 CTNNA P42704 Leucine-rich PPR motif-containing protein, LRPPRC Q ;Q ;Q15029 Q5JRX3;Q5JRX3-2;Q5JRX3-3;A0A0A0MRX9 116 kda U5 small nuclear ribonucleoprotein component EFTUD Presequence protease, PITRM P48735;P Isocitrate dehydrogenase [NADP], IDH P11387 DNA topoisomerase 1 TOP Q3SXM5-2;Q3SXM5;H3BQI 7;H3BT52 Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U 2-2;Q9H2U2-4;D6R967 O43143 Q9Y3B3-2;Q9Y3B3;Q86XR 7-2 Q ;Q15233;C9IZL7; H7C367;C9JYS8 Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL Inorganic pyrophosphatase 2, PPA Putative pre-mrna-splicing factor ATP-dependent RNA helicase DHX15 DHX Transmembrane emp24 domain-containing protein 7 TMED Non-POU domain-containing octamer-binding protein NONO O ;O43852;O ;O ;H0Y875;O ;O ;O Calumenin CALU O ;E9PDF6;O P ;Q5T6W5;P6197 8;P ;Q5T6W2 Q ;Q ;Q92841;H3BLZ8 ;Q Q9ULA0;E7ETB3; E7EMB6;B9ZVU2; F8WAN0 Unconventional myosin-ib MYO1B Heterogeneous nuclear ribonucleoprotein K HNRNPK Probable ATP-dependent RNA helicase DDX17 DDX Aspartyl aminopeptidase DNPEP Q8TAQ2-2;Q8TAQ2-3;Q8TAQ2;F8VXC SWI/SNF complex subunit SMARCC2 SMARCC Q9HDC9-2;H0Y512;Q9HDC Adipocyte plasma membrane-associated protein APMAP P12004 Proliferating cell nuclear antigen NA O ;O96011 Peroxisomal membrane protein 11B PEX11B P62826;B5MDF5; J3KQE5;F5H018; H0YFC6 GTP-binding nuclear protein Ran RAN S107

108 P26373;J3QSB4;P S ribosomal protein L13 RPL P20700;E9PBF6 Lamin-B1 LMNB A0A0A0MRM8;Q9 UM54-6;Q9UM54-5;Q9UM54-2;Q9UM54-4;Q9UM54-1;Q9UM54;E7EW 20 Q99497;K7ELW0; K7EN27 Unconventional myosin-vi MYO Protein DJ-1 PARK Q96AE4;Q96AE4-2;E9PEB5 Far upstream element-binding protein 1 FUBP A6NLN1;P26599; P ;P Polypyrimidine tract-binding protein 1 PTBP P38646 Stress-70 protein, HSPA O43242;O S proteasome non-atpase regulatory subunit 3 PSMD P08621;P ;P ;M0QYR1 U1 small nuclear ribonucleoprotein 70 kda SNRNP Q14697;Q ;F5H6X6;E9PKU Neutral alpha-glucosidase AB GANAB Q9P258 Protein RCC2 RCC P55795 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2, N- terminally processed HNRNPH Q9UL25 Ras-related protein Rab-21 RAB P40926;P ;G3XAL0 Malate dehydrogenase, ;Malate dehydrogenase MDH P30405;R4GN99; P ;H0Y548 Peptidyl-prolyl cis-trans isomerase F, ;Peptidyl-prolyl cis-trans isomerase PPIF Q06323;Q ;Q Q ;B0QYK0;Q ;Q01844;Q ;H7BY36;Q ;C9JGE3 Proteasome activator complex subunit 1 PSME RNA-binding protein EWS EWSR Q16778;P33778;P 23527;P06899;Q8 N257;Q96A08 Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3- B;Histone H2B type 1-A HIST2H2BE;H IST1H2BB;HI ST1H2BO;HIS T1H2BJ;HIST 3H2BB;HIST1 H2BA P61158;B4DXW1 Actin-related protein 3 ACTR Q00765;E2QRG8 Receptor expression-enhancing protein 5 REEP P ;P ;P11177 P14618;P ;P ;H3BTN5;B4DNK 4;H3BQ34 Pyruvate dehydrogenase E1 component subunit beta, PDHB Pyruvate kinase PKM;Pyruvate kinase PKM H7BZJ3 Thioredoxin TXN E7END7;P62820; P ;Q92928 Q9Y2Z0-2;Q9Y2Z0 Ras-related protein Rab-1A;Putative Ras-related protein Rab-1C RAB1A;RAB1 C Suppressor of G2 allele of SKP1 homolog SUGT S108

109 Q96C19 EF-hand domain-containing protein D2 EFHD H3BLU7;O43488 Aflatoxin B1 aldehyde reductase member 2 AKR7A O ;O ;O75369;O ;O ;O ;E7EN95;O ;O ;O Filamin-B FLNB O14929;O Histone acetyltransferase type B catalytic subunit HAT P ;E9PQ63;A8MTM 1;P16152 Carbonyl reductase [NADPH] 1 CBR P35579;P Myosin-9 MYH P51659;E7ER27;E 7EWE5;P ;P ;G5E9S2;E7ET1 7 O95470;H0Y3V8; H7BXL7 Peroxisomal multifunctional enzyme type 2;(3R)- hydroxyacyl-coa dehydrogenase;enoyl-coa hydratase 2 HSD17B Sphingosine-1-phosphate lyase 1 SGPL P49721 Proteasome subunit beta type-2 PSMB Q9Y696 Chloride intracellular channel protein 4 CLIC P35232;C9JW96; C9JZ20;E7ESE2; E9W0 Prohibitin PHB Q16531;F5GY55 DNA damage-binding protein 1 DDB Q3ZCQ8;Q3ZCQ8 - Mitochondrial import inner membrane translocase subunit TIMM ;M0R0C3;M0R2F TIM50 8;Q3ZCQ8-3 P46783;F6U211;S 4R435;Q9NQ39 P62316;K7ERG4; P Q9P0L0;Q9P0L0-2 Q9HCC0;Q9HCC0-2;D6RD67;D6RDF 7 P ;P ;P05023;P ;M0R116;P13637 ;P ;P ;A0A0A0MT26 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like RPS10;RPS10 P Small nuclear ribonucleoprotein Sm D2 SNRPD Vesicle-associated membrane protein-associated protein A Methylcrotonoyl-CoA carboxylase beta chain, Sodium/potassium-transporting ATPase subunit alpha- 1;Sodium/potassium-transporting ATPase subunit alpha- 3 VAPA MCCC ATP1A1;ATP1 A H0Y4R1;P12268 Inosine-5-monophosphate dehydrogenase 2 IMPDH A0A087X163;Q9N P72;Q9NP72-2;Q9NP72-3;Q5W0J0 P62993;J3KT38;P A0A087X2E5;O ;O43837;A0A087 WZN1;O Ras-related protein Rab-18 RAB Growth factor receptor-bound protein 2 GRB Isocitrate dehydrogenase [NAD] subunit beta, IDH3B P13804;P ;H0YLU7;H0YL1 2;H0YKF0;H0YK4 9;H0YNX6 Q13263;Q ;M0R0K9 Electron transfer flavoprotein subunit alpha, ETFA Transcription intermediary factor 1-beta TRIM S109

110 P59998;F8WCF6; P ;F8WDD7;H7C0 A3;P ;R4GN08;P P04406;P ;E7EUT5 Actin-related protein 2/3 complex subunit 4 AR4;AR 4-TTLL Glyceraldehyde-3-phosphate dehydrogenase GAPDH P53004 Biliverdin reductase A BLVRA G3V4W0;B4DY08; B2R5W2;G3V4C1; P ;G3V576;P ;G3V2Q1;P0791 Heterogeneous nuclear ribonucleoproteins C1/C2 HNRN ;G3V555;G3V57 5;G3V5X6;G3V3K 6;G3V251;B4DSU 6 Q92945;A0A087W TP3;M0R0I5 Far upstream element-binding protein 2 KHSRP Q9UQ80-2;Q9UQ80;F8VR7 Proliferation-associated protein 2G4 PA2G P48047;H7C0C1 ATP synthase subunit O, ATP5O P ;P50995;H0Y6E1 Q ;Q13247;Q08170 P12532;P ;F8WCN3;C9JS Q1 B0QZK4;Q5SWC8 ;X6RGJ2;Q5SSJ5-2;Q5SSJ5;Q5SSJ 5-3 Annexin A11 ANXA Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 4 Creatine kinase U-type, SRSF6;SRSF 4 CKMT1A;CKM T1B Heterochromatin protein 1-binding protein 3 HP1BP P05783;F8VZY9 Keratin, type I cytoskeletal 18 KRT P39748;P Flap endonuclease 1 FEN Q9Y2X3 Nucleolar protein 58 NOP Q99880;Q99879; Q99877;Q93079; Q5QNW6;P62807; P58876;O60814;Q 5QNW6-2;U3KQK0;P Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2- F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1- D;Histone H2B type 1-K;Histone H2B type F-S HIST1H2BL;HI ST1H2BM;HIS T1H2BN;HIST 1H2BH;HIST2 H2BF;HIST1H 2BC;HIST1H2 BD;HIST1H2B K;H2BFS P25786;P ;F5GX11 Proteasome subunit alpha type-1 PSMA E7EPB3;P S ribosomal protein L14 RPL P ;P30044;P ;P U3KQC1;A0A0A0 MQU0;Q9BV38;K 7EIR0 P ;P49419;F8VS02 ;P ;P P02545;P ;P ;P ;P Peroxiredoxin-5, PRDX WD repeat-containing protein 18 WDR Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A Prelamin-A/C;Lamin-A/C LMNA S110

111 Q ;Q ;Q92598;Q ;A0A0A0MSM0 P38159;P ;H0Y6E7;H3BT7 1;Q96E39;H3BUY 5 Heat shock protein 105 kda HSPH RNA-binding motif protein, X chromosome;rna-binding motif protein, X chromosome, N-terminally processed;rna binding motif protein, X-linked-like-1 RBMX;RBMXL Q16762 Thiosulfate sulfurtransferase TST O00264 Membrane-associated progesterone receptor component 1 PGRMC P ;P50991 T-complex protein 1 subunit delta CCT P27361;E9PBK7; E9PQW4;P ;E9PJF0;P ;B3KR49 Mitogen-activated protein kinase 3 MAPK P28074;P Proteasome subunit beta type-5 PSMB Q7Z434-4;Q7Z434 Mitochondrial antiviral-signaling protein MAVS Q9H307;Q9H307-2 Pinin PNN O60313;E5KLK1; E5KLJ6;E5KLJ9;O ;E5KLJ5 Dynamin-like 120 kda protein, ;Dynaminlike 120 kda protein, form S1 OPA Q1KMD3;H3BQZ7 Heterogeneous nuclear ribonucleoprotein U-like protein 2 HNRNPUL2;h CG_ P43304;P Glycerol-3-phosphate dehydrogenase, GPD P ;P36542 ATP synthase subunit gamma, ATP5C O43175;Q5SZU1 D-3-phosphoglycerate dehydrogenase PHGDH P28070 Proteasome subunit beta type-4 PSMB P00558;P Phosphoglycerate kinase 1 PGK P ;P25788 Proteasome subunit alpha type-3 PSMA P37837;F2Z393 Transaldolase TALDO K7EK20;K7EPK1; Q86X55-2;Q86X55-1;Q86X55;K7EQA 8 Histone-arginine methyltransferase CARM1 CARM Q07020;J3QQ67; Q ;G3V203;H0YHA 7;F8VYV2;F8VUA 6;A0A075B7A0 60S ribosomal protein L18 RPL Q9NZ01;M0R3C3 Very-long-chain enoyl-coa reductase TECR P Very long-chain specific acyl-coa dehydrogenase, 2;P49748;P ACADVL Q9UJ70;Q9UJ70-2;H7C3G9;C9JEV 6;H7C1L7;H0YEB 7;H7C286 N-acetyl-D-glucosamine kinase NAGK P ;P61019 Ras-related protein Rab-2A RAB2A P25205;P ;J3KQ69 DNA replication licensing factor MCM3 MCM P21796;C9JI87 Voltage-dependent anion-selective channel protein 1 VDAC Q9Y265;Q9Y265-2;E7ETR0 RuvB-like 1 RUVBL P ;H0YNW5;H0YK C5;P33316;H0YM M5;H0YNJ9;H0YK I0;H0YMP1 Deoxyuridine 5-triphosphate nucleotidohydrolase, DUT S111

112 P40939 Trifunctional enzyme subunit alpha, ;Longchain enoyl-coa hydratase;long chain 3-hydroxyacyl- CoA dehydrogenase HADHA P56537;B7ZBH1; P P ;P53396;P Q14694;Q ;Q Q9NSD9;Q9NSD9-2 J3KNQ3;Q9UNM6 ;A0A087WUL9;H0 YD73;E9PL38;Q9 UNM6-2 Q9UJZ1-2;Q9UJZ1;A0A087 WYB4 P60953;P ;Q5JYX0 P60900;G3V5Z7; G3V295;P ;G3V3U4;G3V3I1 O43390;O ;O ;B4DT28;O Eukaryotic translation initiation factor 6 EIF ATP-citrate synthase ACLY Ubiquitin carboxyl-terminal hydrolase 10 USP Phenylalanine--tRNA ligase beta subunit FARSB S proteasome non-atpase regulatory subunit 13 PSMD Stomatin-like protein 2, STOML Cell division control protein 42 homolog CDC Proteasome subunit alpha type-6;proteasome subunit alpha type Heterogeneous nuclear ribonucleoprotein R PSMA HNRNPR;HN RPR Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B D6R9P3;D6RD18; Q ;D6RBZ0;A0A08 7WZV1;Q Heterogeneous nuclear ribonucleoprotein A/B HNRNPAB ;Q ;Q99729 P68402;P ;P ;J3KNE3;P68402 Platelet-activating factor acetylhydrolase IB subunit beta PAFAH1B P54727;P ;H0Y579 UV excision repair protein RAD23 homolog B RAD23B O S proteasome non-atpase regulatory subunit 14 PSMD B4DJ81;P ;P ;P ;P28331;P NADH-ubiquinone oxidoreductase 75 kda subunit, NDUFS P29401;P Transketolase TKT Q7L5L3-1;Q7L5L3 K7EQ02;Q96EP5-2;K7EQ55;K7EK3 3;Q96EP5 G3V4N7;P12277; G3V461 Glycerophosphodiester phosphodiesterase domaincontaining protein 3 GDPD DAZ-associated protein 1 DAZAP Creatine kinase B-type CKB Q96NB2 Sideroflexin-2 SFXN P25787 Proteasome subunit alpha type-2 PSMA P62805 Histone H4 HIST1H4A C9J979;Q5TA45-2;Q5TA45-3;Q5TA45;Q96HV 7;C9IYS7;A0A087 WYI0;Q5TA45-4;Q5TA45-5 Integrator complex subunit 11 CPSF3L S112

113 P40429;M0QYS1; Q8J015;Q6NVV1 C9J8Q5;P51649;P Q9H9B4;D6RDG7 ;S4R2X2;D6RFI0 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a-like MGC87657 RPL13A;RPL1 3a Succinate-semialdehyde dehydrogenase, ALDH5A Sideroflexin-1 SFXN B1AH87;P30536 Translocator protein TSPO Q ;Q07666 KH domain-containing, RNA-binding, signal transductionassociated protein 1 KHDRBS Q14566 DNA replication licensing factor MCM6 MCM A0A087WZH7;P Myristoylated alanine-rich C-kinase substrate MARCKS Q09666 Neuroblast differentiation-associated protein AHNAK AHNAK P07814;V9GYZ6 Bifunctional glutamate/proline--trna ligase;glutamate-- trna ligase;proline--trna ligase EPRS Q96CS3 FAS-associated factor 2 FAF P12236;I7HJJ0;P P02794;G3V192;E 9PRK8;G3V1D1;E 9PKY7 P62158;E7ETZ0;H 0Y7A7;E7EMB3;F 8WBR5;M0QZ52; G3V479;G3V361; Q96HY3 M0QXM4;Q15758; Q ;Q P43243;A8MXP9; D6REM6;D6R991 P25705;P ;P ;K7EK77;K7ERX 7 P ;P31040;D6RFM 5;P ;A0A087X1I3 O00231;O ;J3QRY4 Q71UI9;P0C0S5; Q71UI9-4;Q71UI9-2;C9J0D1;Q71UI9-3 ADP/ATP translocase 3;ADP/ATP translocase 1 SLC25A6;SLC 25A Ferritin heavy chain;ferritin FTH Calmodulin CALM1;CALM 2;CALM Neutral amino acid transporter B(0) SLC1A Matrin-3 MATR ATP synthase subunit alpha, ATP5A Succinate dehydrogenase [ubiquinone] flavoprotein subunit, SDHA S proteasome non-atpase regulatory subunit 11 PSMD Histone H2A.V;Histone H2A.Z;Histone H2A H2AFV;H2AF Z B4DLN1;Q9UBX3; Q9UBX3-2 P kda heat shock protein, HSPD Q9H3U1-2;Q9H3U1 Protein unc-45 homolog A UNC45A Q15125;C9J719;C 9JJ78 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase EBP P ;E7EQ29;P ;P16278 Mitochondrial dicarboxylate carrier SLC25A Beta-galactosidase GLB Q92616 Translational activator GCN1 GCN1L Q96FJ2;P63167 Q9Y679-3;Q9Y679-2;Q9Y679 Dynein light chain 2, cytoplasmic;dynein light chain 1, cytoplasmic DYNLL2;DYN LL Ancient ubiquitous protein 1 AUP S113

114 P10412;P16403;P 16402;Q02539 Histone H1.4;Histone H1.2;Histone H1.3;Histone H1.1 HIST1H1E;HI ST1H1C;HIST 1H1D;HIST1H 1A P ;P07954 Fumarate hydratase, FH Q99714;Q ;Q5H928 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B Q9UBQ7;U3KQ56 ;Q5T946 Glyoxylate reductase/hydroxypyruvate reductase GRHPR Q9Y5S9;Q9Y5S9-2 RNA-binding protein 8A RBM8A P50454;E9PKH2; E9PR70;E9PPV6 Serpin H1 SERPINH Q8NDH3-5;Q8NDH3-4;Q8NDH3;Q8ND Probable aminopeptidase NPEPL1 NPEPL H3-2;Q8NDH3-3;H0YEP3 Q96CN7;D6RGE2 Isochorismatase domain-containing protein 1 ISOC P13716;P Delta-aminolevulinic acid dehydratase ALAD P38117;P ;M0QY67 Electron transfer flavoprotein subunit beta ETFB A0A087WZZ5;Q1 3435;E9PPJ0;H0Y Splicing factor 3B subunit 2 SF3B EX5 O ;O96019 Actin-like protein 6A ACTL6A Q8NF37 Lysophosphatidylcholine acyltransferase 1 LAT P14174 Macrophage migration inhibitory factor MIF Q99798;A2A274 Aconitate hydratase, ACO P ;E9PEX6;P09622 ;P Dihydrolipoyl dehydrogenase, DLD P22087;M0R0P1; M0R299;M0QXL5; M0R2Q4;M0R2U2 ;M0R1H0;M0R2B0 rrna 2-O-methyltransferase fibrillarin FBL O75439;G3V0E4 Mitochondrial-processing peptidase subunit beta PMB P20618 Proteasome subunit beta type-1 PSMB Q12874 Splicing factor 3A subunit 3 SF3A P16615;P ;P ;P Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A ;H7C5W9;P F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;Q9NQ C3- Reticulon-4 RTN ;H7C106;Q9NQC 3-4;Q9NQC3-6 B1AHB1;P33992 DNA replication licensing factor MCM5 MCM A6NDG6 Phosphoglycolate phosphatase PGP P61962;A0A087W WI6 Q8NFV4;Q8NFV4-4;Q8NFV4-6 P16435;H0Y4R2; E7EMD0 A0A087X1K9;E5R GR0;O ;O75608;E5RJ48 DDB1- and CUL4-associated factor 7 DCAF Alpha/beta hydrolase domain-containing protein 11 ABHD NADPH--cytochrome P450 reductase POR Acyl-protein thioesterase 1 LYPLA Q08380 Galectin-3-binding protein LGALS3BP S114

115 O ;O ;O15294;O Q9HC38-3;I3L3Q4;Q9HC38-2;F6TLX2;I3L1F4; Q9HC38 P ;P30048 P ;K7EJE8;K7EKE 6;P ;P36776;K7ER27 UDP-N-acetylglucosamine--peptide N- acetylglucosaminyltransferase 110 kda subunit OGT Glyoxalase domain-containing protein 4 GLOD Thioredoxin-dependent peroxide reductase, PRDX Lon protease homolog, LONP Q16777;Q6FI13;Q 99878;Q96KK5;Q 9BTM1;P0C0S8;P 20671;Q9BTM1-2;H0YFX9;Q9307 7;Q7L7L0;P04908; Q96QV6 Histone H2A type 2-C;Histone H2A type 2-A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A.J;Histone H2A type 1;Histone H2A type 1-D;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1- B/E;Histone H2A type 1-A HIST2H2AC;H IST2H2AA3;HI ST1H2AJ;HIS T1H2AH;H2A FJ;HIST1H2A G;HIST1H2AD ;HIST1H2AC; HIST3H2A;HI ST1H2AB;HIS T1H2AA P24752 Acetyl-CoA acetyltransferase, ACAT P63151;P P ;P62318;H3BT13 Serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B alpha isoform PPP2R2A Small nuclear ribonucleoprotein Sm D3 SNRPD P29373;Q5SYZ4 Cellular retinoic acid-binding protein 2 CRABP P08754 Guanine nucleotide-binding protein G(k) subunit alpha GNAI P07339;H7C1V0 Cathepsin D;Cathepsin D light chain;cathepsin D heavy chain CTSD P52292 Importin subunit alpha-1 KPNA Q ;I3L1P8;Q02978 Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A Q8NFW8;Q8NFW 8-2 N-acylneuraminate cytidylyltransferase CMAS Q ;Q04760 Lactoylglutathione lyase GLO Q8NEZ5-3;Q8NEZ5;H3BTH F-box only protein 22 FBXO P ;I3L0N3;P46459 Vesicle-fusing ATPase NSF O43760;O ;K7ELD9;K7ENG 9;K7ELS8 B4DK69;P52895;A 0A0A0MSD5;S4R 3P0;Q04828;A0A0 A0MT30;H0Y804 Synaptogyrin-2 SYNGR Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 AKR1C2;AKR 1C Q9UJU6-6;B4DDD6;Q9UJU 6;Q9UJU6-2;Q9UJU6- Drebrin-like protein DBNL ;Q9UJU6-4;H0Y5J4;Q9UJU 6-3 P06733;P Alpha-enolase ENO S115

116 P07858;E9PR54;E 9PJ67;E9B3;E 9PKQ7;E9PNL5;E 9PHZ5;E9PLY3;E 9PSG5;E9PQM1 Cathepsin B;Cathepsin B light chain;cathepsin B heavy chain CTSB F5GWX5;Q14839; Q ;Q8TDI0 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5 CHD4;CHD B5MCX3;Q15019; Q ;Q ;C9J2Q4;H7C2Y 0;H7C310 Septin-2 SEPT P32119;A6NIW5 Peroxiredoxin-2 PRDX P ;P48729;D6REM 4;P ;H0Y9X2;U3KQK 7;E7ETM0;Q8N75 2 Q4VXZ8;Q9NUI1; Q9NUI1-3 Casein kinase I isoform alpha;casein kinase I isoform alpha-like CSNK1A1;CS NK1A1L Peroxisomal 2,4-dienoyl-CoA reductase DECR Q96I24 Far upstream element-binding protein 3 FUBP P09110;H7C131;C 9JDE9;H0Y4D4;P ketoacyl-CoA thiolase, peroxisomal ACAA Q9BSH4 Translational activator of cytochrome c oxidase 1 TACO F5H6P7;P ;P61326;Q96A72 Q8WVV9-5;B7WPG3;Q8WV V9-4;C9IYN3;Q8WVV 9;D6W592;H7C46 4 Q96G23;Q5SZE2; Q5SZE3;H0YKH6; Q5SZE4;Q5SZE1 Protein mago nashi homolog;protein mago nashi homolog 2 Heterogeneous nuclear ribonucleoprotein L-like MAGOHB;MA GOH HNRNPLL;HN RPLL Ceramide synthase 2 CERS Q09161 Nuclear cap-binding protein subunit 1 NCBP P42765;K7EME0 3-ketoacyl-CoA thiolase, ACAA F5GXX5;P61803; F5H895 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 DAD Q8NBX0 Saccharopine dehydrogenase-like oxidoreductase SCCPDH P ;P26440;A0A0A0 MT83;H0YKV0;H0 YLC3;H7C4G6 Isovaleryl-CoA dehydrogenase, IVD O75643 U5 small nuclear ribonucleoprotein 200 kda helicase SNRNP J3KTJ8;J3QRI7;J3 QQQ9;J3QQV1;E 5RIT6;J3QRC4;Q 9UNX3;P S ribosomal protein L26-like 1;60S ribosomal protein L26 RPL26;KRBA2 ;RPL26L Q9BYJ9;A0A024R 7W5;A0A087X0Q 1;Q7Z739;A0A087 WY31;Q9Y5A9-2;A0A087WXZ3;Q 9Y5A9 YTH domain family protein 1;YTH domain family protein 3;YTH domain family protein 2 YTHDF1;YTH DF3;YTHDF Q8N2K0;Q8N2K0-2;Q8N2K0-3 Monoacylglycerol lipase ABHD12 ABHD S116

117 A0A0A0MR52;Q ;Q ;Q ;E7EX73;Q ;E9PGM1;Q ;E7EUU4;Q0463 7;Q ;Q P06576;H0YH81;F 8W079 P05198;H0YJS4; G3V4T5 Eukaryotic translation initiation factor 4 gamma 1 EIF4G ATP synthase subunit beta, ;ATP synthase subunit beta ATP5B Eukaryotic translation initiation factor 2 subunit 1 EIF2S Q ;Q S proteasome non-atpase regulatory subunit 5 PSMD Q96AB3;Q96AB3-2;K7ENV7;K7EK W4 Isochorismatase domain-containing protein 2, ISOC P49736;H0Y8E6 DNA replication licensing factor MCM2 MCM P50213;H0YLI6;H 0YMU3;H0YL72;H 0YKD0;P Q9BY42;A0A0A0 MQR2;A2A2L5 P33993;P ;P Isocitrate dehydrogenase [NAD] subunit alpha, IDH3A Protein RTF2 homolog RTFDC DNA replication licensing factor MCM7 MCM P37108;H0YLA2 Signal recognition particle 14 kda protein SRP Q ;Q99460;A0A087 WW66;H7C378 Q9Y3Q3;G3V1J9; F5H4M7;Q9Y3Q3-2 P ;P35637;H3BPE7 A0A096LPI6;P300 42;A0A096LNH5; H7C2G3;H7C1F6; P ;A0A096LP73;F2 Z2Q0;H7BYH1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX 3;F8VSA4;F8VRE 9;F8VTT6;F8VVB 7;B4E3S0 26S proteasome non-atpase regulatory subunit 1 PSMD Transmembrane emp24 domain-containing protein 3 TMED RNA-binding protein FUS FUS ES1 protein homolog, C21orf Coronin-1C;Coronin CORO1C Q8N335;C9JFA7 Glycerol-3-phosphate dehydrogenase 1-like protein GPD1L P10253 Lysosomal alpha-glucosidase;76 kda lysosomal alphaglucosidase;70 kda lysosomal alpha-glucosidase GAA Q9BZE4-2;Q9BZE4;Q9BZE 4-3 Q ;Q14914;F2Z3J9 Nucleolar GTP-binding protein 1 GTPBP Prostaglandin reductase 1 PTGR P04181;P Ornithine aminotransferase, ;Ornithine aminotransferase, hepatic form;ornithine aminotransferase, renal form OAT P51858;P ;P Hepatoma-derived growth factor HDGF S117

118 P61619;B4DR61; H7C1Q9;C9JXC6; H7C069;A6NK38; F2Z2C7;A6NIF9;C 9JJV4;P ;F8W776;Q8TC2 4;Q9H9S3-2;Q9H9S3-3;Q9H9S3 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 SEC61A1;SE C61A Q92820 Gamma-glutamyl hydrolase GGH J3QS39;J3QTR3; F5H6Q2;P62987;F 5GYU3;F5H2Z3;F 5H265;B4DV12;F5 H388;P62979;F5H 747;F5GXK7;J3Q KN0;Q5PY61;P0C G47;Q96C32;P0C G48;M0R1V7;A0A 087WV77;M0R1M 6;M0R2S1;J3QLP 7;J3QRK5;J3QSA 3;K7EMA8;F5GZ3 9 A0FGR8-4;H7BXI1;A0FGR 8-2;A0FGR8;A0A08 7WXU3;A0FGR8-6 P49458;E9PE20;P Q32MZ4-3;Q32MZ4-2;Q32MZ4 P53597;H7C233 P82979;F8VZQ9; H0YHG0 O75223;O ;M0QZK8;B8ZZK 2 Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin- B;Ubiquitin;Polyubiquitin-C;Ubiquitin UBB;RPS27A; UBC;UBA52;U BBP Extended synaptotagmin-2 ESYT Signal recognition particle 9 kda protein SRP Leucine-rich repeat flightless-interacting protein 1 LRRFIP Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, SUCLG SAP domain-containing ribonucleoprotein SARNP Gamma-glutamylcyclotransferase GGCT Q9HCY8 Protein S100-A14 S100A P ;B4DXZ6;P51114 ;C9JAJ4;E7EU85; E9PFF5;P ;R9WNI0;A8MQB Fragile X mental retardation syndrome-related protein 1;Fragile X mental retardation protein 1;Fragile X mental retardation syndrome-related protein 2 FXR1;FMR1;F XR ;Q ;Q ;G3V0J0;Q ;Q ;Q ;Q ;Q ;Q ;Q06787;P51116 P11498 Pyruvate carboxylase, P ;P05165;P Propionyl-CoA carboxylase alpha chain, CA S118

119 Table S3: Competitive ABPP-SILAC with 1000 nm AA-CW236 pretreatment followed by AA-CW159A treatment. Protein IDs Protein names Gene names P16455 Methylated-DNA--protein-cysteine methyltransferase SILAC ratio AA- CW236/DMSO SEM MGMT Q9H7Z7;A6NHH0 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form PTGES P35579;P Myosin-9 MYH Q7Z406;Q7Z406-6;F2Z2U8;Q7Z406-2;G8JLL9;Q7Z406-5;Q7Z406-4;M0QY43 Myosin-14 MYH P04080 Cystatin-B CSTB P07858;R4GMQ5 Cathepsin B;Cathepsin B light chain;cathepsin B heavy chain CTSB P14735;P Insulin-degrading enzyme IDE B8ZZL8;P61604;S4R3N1 10 kda heat shock protein, HSPE Q96I99;H0Y852;E9PDQ8;Q96 I99-2 P05198;H0YJS4;G3V4T5 P07339;H7C469;H7C1V0;F8 WD96;C9JH19 Succinyl-CoA ligase [GDP-forming] subunit beta, Eukaryotic translation initiation factor 2 subunit 1 Cathepsin D;Cathepsin D light chain;cathepsin D heavy chain SUCLG EIF2S CTSD P ;P protein sigma SFN P12532;F8WCN3;P ;C9JSQ1 Creatine kinase U-type, CKMT1A;CKMT 1B P29373;Q5SYZ4 Cellular retinoic acid-binding protein 2 CRABP P31949 Protein S100-A11 S100A K7EP65;K7EKS7;K7ELC4;K7 EMH1;K7ERI7;P35268;K7EJT 5 60S ribosomal protein L22 RPL O ;O94925;H7BZD1;O Glutaminase kidney isoform, GLS O00231;O S proteasome non-atpase regulatory subunit 11 PSMD Q07065 Cytoskeleton-associated protein 4 CKAP P25787 Proteasome subunit alpha type-2 PSMA P04406;P ;E7EUT5 P21796;C9JI87 Glyceraldehyde-3-phosphate dehydrogenase Voltage-dependent anion-selective channel protein 1 GAPDH VDAC P18669;P15259 Phosphoglycerate 1;Phosphoglycerate mutase 2 mutase PGAM1;PGAM Q9Y446;Q9Y446-2 Plakophilin-3 PKP P13693;Q5W0H4;H0YCX0;Q8 TBK7;Q56UQ5;J3KPG2;E9PJ F7 Translationally-controlled protein;tpt1-like protein tumor TPT Q92747;E9PF58;B4DLQ7 Actin-related protein 2/3 complex subunit 1A AR1A S119

120 J3KN67;P06753;Q5VU63 Tropomyosin alpha-3 chain TPM Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS M0R261;O95336;M0R0U3 6-phosphogluconolactonase PGLS P49721 Proteasome subunit beta type-2 PSMB O43242;B4DT72 Q9Y2W1 E9PL22;Q9Y4L1;B7Z909;E9P J21 M0R0Y2;P54920;M0R027;M0 R058;M0R2M1 O ;O ;E7ET15;O15042;C9JB80 Q7L5D6;C9JPA8;C9JY46;C9J HN8;Q7L5D6-2 26S proteasome non-atpase regulatory subunit 3 Thyroid hormone receptor-associated protein 3 PSMD THRAP Hypoxia up-regulated protein 1 HYOU Alpha-soluble NSF attachment protein NAPA U2 snrnp-associated SURP motifcontaining protein U2SURP Golgi to ER traffic protein 4 homolog GET M0R0F0;P46782;M0QZN2;M0 R0R2 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed RPS Q9BZZ5-3;Q9BZZ5-2;G3V1C3;Q9BZZ5;E9PQK6; Q9BZZ5-5;B4E283 Q96QK1 Apoptosis inhibitor 5 API Vacuolar protein sorting-associated protein 35 VPS P09972;K7EKH5;C9J8F3;J3K SV6;J3QKP5;A8MVZ9 Fructose-bisphosphate aldolase C;Fructosebisphosphate aldolase ALDOC Q9UJS0;Q9UJS0-2;F5GX33 Calcium-binding carrier protein Aralar2 SLC25A P61106 Ras-related protein Rab-14 RAB O00186 Syntaxin-binding protein 3 STXBP Q6PKG0-3;Q6PKG0;E5RH50 La-related protein 1 LARP Q ;Q01518;Q5T0R8;Q5T0S3;Q 5T0R7;Q5T0R6;Q5T0R5;Q5T 0R4;Q5T0R3;Q5T0R2;Q5T0R 1;Q5T0R9 Adenylyl cyclase-associated protein 1 CAP P50402;Q5HY57 Emerin EMD O14818;O ;H0Y586;Q8TAA3-2;Q8TAA3-5;Q8TAA3 J3KTF8;P52565;J3QQX2;J3K RE2;J3KS60;P ;J3KRY1 Proteasome subunit alpha type- 7;Proteasome subunit alpha type-7-like PSMA7;PSMA Rho GDP-dissociation inhibitor 1 ARHGDIA P31150 Rab GDP dissociation inhibitor alpha GDI P30050;P S ribosomal protein L12 RPL Q9Y3E5;J3KQ48 Peptidyl-tRNA hydrolase 2, PTRH Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B STT3B S120

121 P47985;P0C7P4 Cytochrome b-c1 complex subunit Rieske, ;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1;UQC RFS1P H3BSW3;P ;H3BQF1;H3BQZ9;P07741;H 3BQB1 Adenine phosphoribosyltransferase APRT F5GXX5;P61803;F5H895 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 DAD P06576;H0YH81;F8VPV9;F8 W079 ATP synthase subunit beta, ;ATP synthase subunit beta ATP5B Q8TCT9-5;Q8TCT9;Q8TCT9-4;Q8TCT9-2 Minor histocompatibility antigen H13 HM Q96TA1-2;Q96TA1 Niban-like protein 1 FAM129B P51659;E7EWE5;P ;P ;E7ER27;G5E9S2;E7ET17 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;enoyl-coa hydratase 2 HSD17B P ;P49748;P Very long-chain specific acyl-coa dehydrogenase, ACADVL Q9H6S3;B7ZKL3 Epidermal growth factor receptor kinase substrate 8-like protein 2 EPS8L O ;O95782 AP-2 complex subunit alpha-1 AP2A P07355;P ;H0YN42;H0YMD0;H0YMU9; A6NMY6;H0YM50;H0YKS4;H 0YNP5;H0YN28;H0YL33 Annexin A2;Annexin;Putative annexin A2-like protein ANXA2;ANXA2P Q8WXF1-2;Q8WXF1 Paraspeckle component 1 PS G3V2K7;P49755 P00338;P ;P ;P ;P ;F5GXY2 Transmembrane emp24 domain-containing protein 10 TMED L-lactate dehydrogenase A chain LDHA P0CW22;P08708;H0YN88;H0 YK46 40S ribosomal protein S17-like;40S ribosomal protein S17 RPS17L;RPS P ;P62316;K7EJB5;K7ERG4 Small nuclear ribonucleoprotein Sm D2 SNRPD P67936;P Tropomyosin alpha-4 chain TPM D6RAN4;P32969;H0Y9V9;E7 ESE0 J3QS00;I3L1M4;J3QRD1;P51 648;P Q86U42-2;Q86U42;H0YJH9;B4DEH8; G3V4T2;Q P02545;P ;P ;P S ribosomal protein L9 RPL Fatty aldehyde dehydrogenase ALDH3A Polyadenylate-binding protein 2 PABPN Prelamin-A/C;Lamin-A/C LMNA P32119;A6NIW5 Peroxiredoxin-2 PRDX S121

122 P39748;I3L3E9;F5H1Y3;P Flap endonuclease 1 FEN P63167;F8VXL2;F8VRV5;Q96 FJ2 Dynein light chain 1, cytoplasmic;dynein light chain 2, cytoplasmic DYNLL1;DYNLL Q9H845;H0Y8Z9 Acyl-CoA dehydrogenase family member 9, ACAD M0R026;A1L0T0;M0R1B5;E9 PJS0 Acetolactate synthase-like protein ILVBL P60900;G3V5Z7;G3V3U4;G3 V3I1;G3V295;B4DXJ9 Proteasome subunit alpha type- 6;Proteasome subunit alpha type PSMA O ;E9PDF6;O43795 Unconventional myosin-ib MYO1B O ;O ;O ;O95758;O ;O ;O Polypyrimidine tract-binding protein 3 PTBP Q96FQ6 Protein S100-A16 S100A Q ;Q ;Q92598;B4DYH1;B4DY72 Heat shock protein 105 kda HSPH Q ;Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 GFPT P36957;B7Z5W8 Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, DLST Q6PI48 Aspartate--tRNA ligase, DARS E9PKS9;B4DME1;E9PQE8;Q 9Y296;E9PN70;G3V1A0;G5E A23;J3KP27 Trafficking protein particle complex subunit 4 TRAP P48444;B0YIW6;P Coatomer subunit delta ARCN P ;P30044;P ;P Peroxiredoxin-5, PRDX Q5RKV6 Exosome complex component MTR3 EXOSC F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;Q9NQC3-3;H7C106;Q9NQC3-4;F8WAM4;Q9NQC3-6 Reticulon-4 RTN P15311;E7EQR4 Ezrin EZR P protein gamma; protein gamma, N-terminally processed YWHAG Q9BQE3;F5H5D3 Tubulin alpha-1c chain TUBA1C P38919 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed EIF4A D6RFH4;H3BUX2;O43169;J3 KNF8 Cytochrome b5 type B CYB5B P ;P25788 Proteasome subunit alpha type-3 PSMA J3QSA9;J3QQM1;P ;P62195;J3QLH6;J3KRP2 26S protease regulatory subunit 8 PSMC S122

123 P ;P60174;P ;U3KPZ0 F8W1R7;P ;P60660;J3KND3;G8JLA2;G 3V1V0;B7Z6Z4;F8VPF3;G3V1 Y7 Triosephosphate isomerase TPI Myosin light polypeptide 6 MYL Q9UQ80;F8VR77 Proliferation-associated protein 2G4 PA2G P39656;E7EWT1;U3KQ84 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit DDOST B4DDM6;J3QT28;O ;O43684 Mitotic checkpoint protein BUB3 BUB P06744;P ;K7EQ48 Glucose-6-phosphate isomerase GPI Q5VTE0;P68104 Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EEF1A1P5;EEF 1A Q ;Q13243 Serine/arginine-rich splicing factor 5 SRSF P59998;F8WCF6;F8WDD7;P ;P ;H7C0A3 Actin-related protein 2/3 complex subunit 4 AR4;AR4- TTLL P ;H0YNW5;H0YKC5;P33316; H0YMP1;H0YMM5;H0YNJ9;H 0YKI0 O00487 Deoxyuridine 5-triphosphate nucleotidohydrolase, 26S proteasome non-atpase regulatory subunit 14 DUT PSMD H0Y7C0;F5H4X1;O60763;F5 GYR8;O Q ;Q14914;F2Z3J9;Q5JVP3 F5GYN4;Q96FW1;J3KR44;F5 H6Q1;F5GYJ8;F5H3F0;Q96F W1-2 General vesicular transport factor p115 USO Prostaglandin reductase 1 PTGR Ubiquitin thioesterase OTUB1 OTUB P ;P43246;E9PHA6 DNA mismatch repair protein Msh2 MSH Q S ribosomal protein L6 RPL M0QZK8;O75223;O Gamma-glutamylcyclotransferase GGCT Q07021;I3L3Q7;I3L3B0 Complement component 1 Q subcomponentbinding protein, C1QBP H0YMZ1;H0YN18;H0YL69;P2 5789;P ;H0YKT8;H0YMA1 Proteasome subunit alpha type;proteasome subunit alpha type-4;proteasome subunit beta type PSMA F8WAU4;C9IZ01;Q96RP9;Q9 6RP9-2 Elongation factor G, GFM F6SBX2;Q9NSE4 Isoleucine--tRNA ligase, IARS O95833;Q5SQ17 Chloride intracellular channel protein 3 CLIC P00558;B7Z7A9;E7ERH5 Phosphoglycerate 1;Phosphoglycerate kinase S123 kinase PGK B4DGU4;P35222 Catenin beta-1 CTNNB P13798;C9JIF9;H7C1U0;C9JL K2;H7C393 Acylamino-acid-releasing enzyme APEH P04792 Heat shock protein beta-1 HSPB

124 P ;P62913;Q5VVC9;Q5VVC8 60S ribosomal protein L11 RPL Q14139;Q Ubiquitin conjugation factor E4 A UBE4A P35232;C9JZ20;E7ESE2;E9P CW0;C9JW96;B4DY47 Prohibitin PHB C9J9K3;P08865;A6NE09 40S ribosomal protein SA RPSA;RPSAP H7C1J3;Q96HY7 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, DHTKD F5GYV3;O76062;H0YEN6;E9 PS18;E9PLS9;O Delta(14)-sterol reductase TM7SF O43776;B4DN60 Asparagine--tRNA ligase, cytoplasmic NARS B4DZI8;P35606 Coatomer subunit beta COPB P28074;P Proteasome subunit beta type-5 PSMB Q5JB52;B7WPG3;Q8WVV9-4;Q8WVV9;D6W592 Heterogeneous nuclear ribonucleoprotein L- like HNRPLL;HNRN PLL P46940;H0YLE8 Ras GTPase-activating-like protein IQGAP1 IQGAP P62277;E9PS50;J3KMX5 40S ribosomal protein S13 RPS Q7Z2K6;E7ER77 Endoplasmic reticulum metallopeptidase 1 ERMP Q15125;C9J719;C9JJ78 E9Y5;Q ;Q beta-hydroxysteroid-Delta(8),Delta(7)- isomerase DNA topoisomerase 2-beta;DNA topoisomerase 2 EBP TOP2B P46977;E9PNQ1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A P48047 ATP synthase subunit O, ATP5O P31930 Cytochrome b-c1 complex subunit 1, UQCRC P58107;E9PPU0 Epiplakin EPPK Q9UN76 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A P30041 Peroxiredoxin-6 PRDX P17812;B7Z9C4 CTP synthase 1 CTPS O ;O00571;B4DXX7;O15523 ATP-dependent RNA helicase DDX3X;ATPdependent RNA helicase DDX3Y DDX3X;DDX3Y O ;O75534;O ;G5E9Q2;E9PLT0 Cold shock domain-containing protein E1 CSDE P51149;C9J592;C9J8S3;C9IZ Z0;C9J4V0 Ras-related protein Rab-7a RAB7A P07384 Calpain-1 catalytic subunit CAPN P62424;Q5T8U2;Q5T8U3 60S ribosomal protein L7a RPL7A O00148;O ;K7EQN7;B1Q2N1 ATP-dependent RNA helicase DDX39A DDX39A;DDX O ;O15020 Spectrin beta chain, non-erythrocytic 2 SPTBN S124

125 Q9Y2Q3-4;E9PFN5;Q9Y2Q3;Q9Y2Q3-3;Q9Y2Q3-2 Glutathione S-transferase kappa 1 GSTK P07737;K7EJ44 Profilin-1 PFN P36542;B4DL14;P ATP synthase subunit gamma, ;ATP synthase subunit gamma ATP5C P43686;P S protease regulatory subunit 6B PSMC B7ZAR1;E9A1;P48643;B4 DYD8;E7ENZ3 T-complex protein 1 subunit epsilon CCT P14625 Endoplasmin HSP90B H0YHC3;F8W020;F8W118;F8 VXI6;F8VUX1;F8VY35;B3KV4 4;F8VV59;B7Z9C2;B3KNT8;F 8W0J6;F5H4R6;H0YIV4;P552 09;H0YH88;F8W543;F8VRJ2 Nucleosome assembly protein 1-like 1 NAP1L B7Z9L0;P50991;P ;B7Z2F4 T-complex protein 1 subunit delta CCT P27824;B4DGP8;B4E2T8 Calnexin CANX P ;P protein beta/alpha; protein beta/alpha, N-terminally processed YWHAB P51572;P ;C9JSP1;C9JQ75;C9J0M4 B-cell receptor-associated protein 31 BCAP P62937;F8WE65;C9J5S7;Q56 7Q0 Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N- terminally processed;peptidyl-prolyl cis-trans isomerase PPIA E5RGY0;B4E1G1;Q9BUN8-2;Q9BUN8 Derlin-1 DERL P11216 Glycogen phosphorylase, brain form PYGB P45973 Chromobox protein homolog 5 CBX P46777;Q5T7N0 60S ribosomal protein L5 RPL P00505;E7ERW2 Aspartate aminotransferase, ;Aspartate aminotransferase GOT Q5JRX3;Q5JRX3-2;Q5JRX3-3 Presequence protease, PITRM P62826;B5MDF5;J3KQE5;F5 H018;H0YFC6 Q ;Q12792;F8VS81;Q GTP-binding nuclear protein Ran RAN Twinfilin-1 TWF P61160;P ;F5H6T1 Actin-related protein 2 ACTR Q15008;C9IZE4;E9PHI9;Q S proteasome non-atpase regulatory subunit 6 PSMD Q8NFW8;Q8NFW8-2 N-acylneuraminate cytidylyltransferase CMAS P08574 Cytochrome c1, heme protein, CYC Q8WUM4;Q8WUM4-2 Programmed cell death 6-interacting protein PDCD6IP O15355 Protein phosphatase 1G PPM1G P ;P14324 Farnesyl pyrophosphate synthase FDPS P41240 Tyrosine-protein kinase CSK CSK S125

126 O ;O75947;F5H608 ATP synthase subunit d, ATP5H Q9NQ88 Fructose-2,6-bisphosphatase TIGAR TIGAR B7Z815;Q93009;F5H8E5;H3B ND8;F5H2X1 Ubiquitin hydrolase;ubiquitin hydrolase 7 carboxyl-terminal carboxyl-terminal USP Q99798;A2A274 Aconitate hydratase, ACO Q16836;E9PF18;Q ;Q Hydroxyacyl-coenzyme A dehydrogenase, HADH P60842;J3KT12;P ;J3KTB5;J3QS69;J3QR64;J3 KSZ0;J3QL43 P22087;M0R0P1;M0R299;M0 QXL5;M0R2Q4;M0R2U2;M0R 1H0;M0R2B0 Eukaryotic initiation factor 4A-I EIF4A rrna 2-O-methyltransferase fibrillarin FBL Q8TDN6 Ribosome biogenesis protein BRX1 homolog BRIX Q ;Q14980;Q ;Q ;Q9BTE9 Q9UHG3;B7Z3Y2;B7Z9P8;F8 W8W4 Nuclear mitotic apparatus protein 1 NUMA Prenylcysteine oxidase 1 YOX Q09161 Nuclear cap-binding protein subunit 1 NCBP P S ribosomal protein S25 RPS P78527;E7EUY0;P P62258;P ;B4DJF2;I3L3T1 DNA-dependent protein kinase catalytic subunit PRKDC protein epsilon YWHAE Q06830 Peroxiredoxin-1 PRDX P ;P47756;B1AK87;B1AK88;B1 AK85;F6USW4 F-actin-capping protein subunit beta CAPZB P ;P68036;P Ubiquitin-conjugating enzyme E2 L3 UBE2L P23284 Peptidyl-prolyl cis-trans isomerase B PPIB Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;Q Plectin PLEC P61088;Q5JXB2;F8VZ29;F8V QQ8;F8VSD4;F8VV71 Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like UBE2N;UBE2NL Septin-7 SEPT P25705;P ;K7ENP3;K7EK77 ATP synthase subunit alpha, ;ATP synthase subunit alpha ATP5A P ;P12814;P ;P ;H9KV75 Alpha-actinin-1 ACTN P61026 Ras-related protein Rab-10 RAB P ;P50416 Carnitine O-palmitoyltransferase 1, liver isoform CPT1A Q6P1M3-2;J3QRV5;Q6P1M3 Lethal(2) giant larvae protein homolog 2 LLGL S126

127 Q9H9P8-2;C9JVN9;Q9H9P8;G3V5S1; G3V272 L-2-hydroxyglutarate dehydrogenase, L2HGDH P49736;H0Y8E6 DNA replication licensing factor MCM2 MCM O ;O43837;O Isocitrate dehydrogenase [NAD] subunit beta, IDH3B P25786;P ;F5GX11;B4DEV8 P04075;J3KPS3;P ;H3BQN4;H3BPS8;H3BUH7; H3BR04 Q14344;F5H1G8 P16615;P ;P ;P ;H7C5W9;P Proteasome subunit alpha type-1 PSMA Fructose-bisphosphate aldolase A;Fructosebisphosphate aldolase Guanine nucleotide-binding protein subunit alpha-13 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ALDOA GNA ATP2A P34932 Heat shock 70 kda protein 4 HSPA P63104;E7EX29;B0AZS6;E7E SK7;P protein zeta/delta YWHAZ F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;B0QZ65;B4DGD8;C9IZ08 GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD O15144 Actin-related protein 2/3 complex subunit 2 AR Q13151 Heterogeneous nuclear ribonucleoprotein A0 HNRNPA P08621;P ;P ;M0QYR1 U1 small nuclear ribonucleoprotein 70 kda SNRNP Q05639 Elongation factor 1-alpha 2 EEF1A P ;P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM P ;P51610;P ;A6NEM2 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N- terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C- terminal chain 6 HCFC Q09666 Neuroblast differentiation-associated protein AHNAK AHNAK Q56VL3 OCIA domain-containing protein 2 OCIAD Q ;Q99832;F5GZK5;Q ;Q ;B7Z1C9 Q07955;J3KTL2;Q ;Q T-complex protein 1 subunit eta CCT Serine/arginine-rich splicing factor 1 SRSF Q5TEC6 0 HIST2H3PS P56192;B3KVK7;A6NC17 Methionine--tRNA ligase, cytoplasmic MARS S127

128 Q9BUH6 Uncharacterized protein C9orf142 C9orf A0AVT1;A0AVT1-4;A0AVT1-3 Ubiquitin-like modifier-activating enzyme 6 UBA Q08J23-2;Q08J23;Q08J23-3 trna (cytosine(34)-c(5))-methyltransferase NSUN Q15393 Splicing factor 3B subunit 3 SF3B Q96CS3 FAS-associated factor 2 FAF Q9H1B7 IRF2BPL O15173;O Membrane-associated progesterone receptor component 2 PGRMC Interferon regulatory factor 2-binding proteinlike B7Z403;Q9HC38-2;Q9HC38;I3L1I0;Q9HC38-3;I3L3Q4 Glyoxalase domain-containing protein 4 GLOD P38117;P Electron transfer flavoprotein subunit beta ETFB B7Z6B8;Q16698;E5RJG7;E5 RFV2 2,4-dienoyl-CoA reductase, DECR P46781;B5MCT8;C9JM19 40S ribosomal protein S9 RPS P ;F8W6I7;P ;P09651;F8VZ49;F8VTQ5;Q 32P51;F8W646 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1-like 2 HNRNPA1;HNR NPA1L B4DHG0;B4DT69;E9PEX6;P Dihydrolipoyl dehydrogenase;dihydrolipoyl dehydrogenase, DLD P11142;E9PKE3;P ;E9PN89;E9PNE6 K7EJR3;R4GMR5;P48556;K7 EJC1 E9PF16;B4DHT5;Q96CM8;B4 DFQ6;B4DUF5 Heat shock cognate 71 kda protein HSPA S proteasome non-atpase regulatory subunit 8 Acyl-CoA synthetase family member 2, PSMD ACSF O00232;O S proteasome non-atpase regulatory subunit 12 PSMD P49411 Elongation factor Tu, TUFM Q7KZF4 P23396;P ;E9PL09;E9PPU1;F2Z2S8;H 0YCJ7;H0YF32;H0YEU2 B1AK13;P35914 B9A041;P ;P40925;P ;B8ZZ51 I3L3P7;P62244;I3L246;H3BN 98 C9JW69;P18754;P ;C9JRH2;C9JMJ4;C9J3R0;C 9JQZ4 Staphylococcal nuclease domain-containing protein 1 SND S ribosomal protein S3 RPS Hydroxymethylglutaryl-CoA lyase, HMGCL Malate dehydrogenase, cytoplasmic MDH S ribosomal protein S15a RPS15A Regulator of chromosome condensation RCC P ;P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP H7BXI1;A0FGR8-6;A0FGR8-2;A0FGR8 Extended synaptotagmin-2 ESYT Q13011;M0R248 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, ECH S128

129 P62805 Histone H4 HIST1H4A B4DVY1;O15371 Eukaryotic translation initiation factor 3 subunit D EIF3D Q7L5L3-1;Q7L5L3 Glycerophosphodiester phosphodiesterase domain-containing protein 3 GDPD Q ;Q15424;Q ;Q ;F5GZU3;B7Z2F6 Scaffold attachment factor B1 SAFB Q15046;Q Lysine--tRNA ligase KARS C9J0J7;P ;G5E9Q6 Profilin-2;Profilin PFN P05388;Q3B7A4;F8VWS0;F8 VU65;F8VPE8;G3V210;F8VW 21;F8VQY6;F8VRK7;F8VZS0; Q8NHW5;F8VS58 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like RPLP0;RPLP0P P45880;P ;P ;Q5JSD2;Q5JSD1;B4DKM5 P63244;J3KPE3;D6RAC2;H0 Y8W2;H0YAF8;H0YAM7;D6R EE5;D6RHH4;D6R9Z1;D6R9L 0;D6RFX4 Voltage-dependent anion-selective channel protein 2 Guanine nucleotide-binding protein subunit beta-2-like 1 VDAC GNB2L P22695;H3BRG4;H3BSJ9;H3 BP04 Q96AE4;Q96AE4-2;E9PEB5;B4DT31 P08754 P12956;B1AHC9;B1AHC8;F5 H1I8 Cytochrome b-c1 complex subunit 2, UQCRC Far upstream element-binding protein 1 FUBP Guanine nucleotide-binding protein G(k) subunit alpha GNAI X-ray repair cross-complementing protein 6 XRCC P60981;P ;F6RFD5 Destrin DSTN P06733;P Alpha-enolase ENO G5E9W3;Q9UKF6 Cleavage and polyadenylation specificity factor subunit 3 CPSF Q5K4L6;Q5K4L6-2 Long-chain fatty acid transport protein 3 SLC27A Q96PK6;Q96PK6-3;Q96PK6-4;F8WDX3;Q96PK6-2;B8ZZ74 RNA-binding protein 14 RBM P63010;P ;P ;K7EJT8 Q14683 AP-2 complex subunit beta AP2B Structural maintenance of chromosomes protein 1A SMC1A Septin-2 SEPT J3QLR8;Q9Y3D9 28S ribosomal protein S23, MRPS Q6DD88;F5H6I7;C9JUU1 Atlastin-3 ATL P ;P ;P19367;P ;E7ENR4 Hexokinase-1 HK Q9H2P0 Activity-dependent neuroprotector homeobox protein ADNP P26640 Valine--tRNA ligase VARS O ;O96019;H7C5S0 Actin-like protein 6A ACTL6A Q14974;J3QR48;B7ZAV6 Importin subunit beta-1 KPNB S129

130 P33993;P DNA replication licensing factor MCM7 MCM P62280;M0QZC5 40S ribosomal protein S11 RPS B5MCF9;O ;O00541;B3KXD6 Pescadillo homolog PES F5H897;Q12931;I3L0K7 Heat shock protein 75 kda, TRAP H3BMT0;H3BTV5;H3BU16;Q9 H910-2;A6NGP5;Q9H910;H3BMV3; B4DLH4 Hematological and neurological expressed 1- like protein HN1L P18124;A8MUD9 60S ribosomal protein L7 RPL P41252;J3KR24 Isoleucine--tRNA ligase, cytoplasmic IARS Q8N1F7;H3BVG0;Q8N1F7-2 Nuclear pore complex protein Nup93 NUP U3KQE2;K7EIV0;P04632;U3K PR7;K7EKD8;K7ELJ7;K7EM7 3 Calpain small subunit 1 CAPNS P08238 Heat shock protein HSP 90-beta HSP90AB O43707;O ;O ;F5GXS2 Alpha-actinin-4 ACTN P27348;E9PG protein theta YWHAQ B4E2W0;P55084;B5MD38;F5 GZQ3;C9JEY0;C9JE81 Trifunctional enzyme subunit beta, ;3-ketoacyl-CoA thiolase HADHB P13010 X-ray repair cross-complementing protein 5 XRCC E5RIW3;O75347;E5RJD8;E5 RHG6;B4DT30 Tubulin-specific chaperone A TBCA P63151;P ;E5RIY1;Q66LE6 Serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B alpha isoform;serine/threonine-protein phosphatase 2A 55 kda regulatory subunit B delta isoform PPP2R2A;PPP2 R2D P00492 Hypoxanthine-guanine phosphoribosyltransferase HPRT Q8IYQ7 Threonine synthase-like 1 THNSL P27797;K7EJB9 Calreticulin CALR Q9Y230;B3KQ59;M0R0Y3 RuvB-like 2 RUVBL F8VYE8;P36873;P ;F8W0W8;F8VR82 Serine/threonine-protein phosphatase;serine/threonine-protein phosphatase PP1-gamma catalytic subunit PPP1CC P14618;P ;P ;H3BTN5;H3BQ34;Q504U3 Pyruvate kinase PKM;Pyruvate kinase PKM;PKM Q8NF37 Lysophosphatidylcholine acyltransferase 1 LAT G3V576;P ;G3V4W0;B4DY08;G3V4C1; P ;G3V2Q1;P07910;G3V555;G 3V575;G3V5X6;G3V3K6;G3V 251;B4DSU6;G3V4M8;P ;O60812 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 1 HNRN;HNRN L M0R389;Q15102 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B S130

131 Q ;Q ;Q ;C9JAB2;Q16629 Serine/arginine-rich splicing factor 7 SRSF P ;P49321;P ;Q5T624;P ;H0YDS9;E9PRH9;H0YF33 Nuclear autoantigenic sperm protein NASP O ;O60832;H7C0M1;C9IYT0;H 7C2Q9 H/ACA ribonucleoprotein complex subunit 4 DKC Q ;Q00610 Clathrin heavy chain 1 CLTC P26196 Probable ATP-dependent RNA helicase DDX6 DDX Q01813;Q phosphofructokinase type C PFKP B4DFK7;E9PQ63;A8MTM1;P E9PKZ0;P62917;G3V1A1;E9P KU4 Carbonyl reductase [NADPH] 1 CBR Septin-9 SEPT S ribosomal protein L8 RPL P53621;P Coatomer subunit alpha;xenin;proxenin COPA P37802 Transgelin-2 TAGLN P40926;E9PDB2;G3XAL0 Malate dehydrogenase, ;Malate dehydrogenase MDH Q9H2U2;Q9H2U2-2;Q9H2U2-3;E2QRM6;Q9H2U2-6;D6R967;B4DFH3;H0Y9D8 Inorganic pyrophosphatase 2, PPA J3KS31;O ;O ;O43670;J3QRS9;O Zinc finger protein 207 ZNF P16435;H0Y4R2;E7EMD0;F5 H468;E7EVY7 B4DDD6;Q9UJU6;Q9UJU6-2;Q9UJU6-3;B4DEM2;C9J7P1;H0Y5J4;B 4DDP6 NADPH--cytochrome P450 reductase POR Drebrin-like protein DBNL Q13155;A8MU58;F8W950 Aminoacyl trna synthase complexinteracting multifunctional protein 2 AIMP B4DWJ2;P47897;H7C0R3 Glutamine--tRNA ligase QARS Q9Y3I0 trna-splicing ligase RtcB homolog C22orf H0YFA4;P52943;P ;H0YHD8 Cysteine-rich protein 2 CRIP P63000;P ;B1AH77;B1AH80;P15153;J3 KSC4;J3QLK0;B1AH78;P Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 2;Ras-related C3 botulinum toxin substrate 3 RAC1;RAC2;RA C P27635;F8W7C6 60S ribosomal protein L10 RPL P55072 Transitional endoplasmic reticulum ATPase VCP P08107;P ;E7EP94;V9GZ37 Q ;Q13813;Q ;A6NG51 Heat shock 70 kda protein 1A/1B HSPA1A Spectrin alpha chain, non-erythrocytic 1 SPTAN S131

132 P ;P61019;E9PKL7;Q8WUD1 Ras-related protein Rab-2A;Ras-related protein Rab-2B RAB2A;RAB2B E9PH29;P30048 Thioredoxin-dependent peroxide reductase, PRDX P ;P08559;P ;P Pyruvate dehydrogenase E1 component subunit alpha, somatic form, PDHA P49588 Alanine--tRNA ligase, cytoplasmic AARS P30043;M0QZL1;M0R192 Flavin reductase (NADPH) BLVRB Q00765 Receptor expression-enhancing protein 5 REEP E9PN18;E9PQ56;H0YEM1;Q9 UHX1-4;Q9UHX1-6;Q9UHX1-3;Q9UHX1-5;Q9UHX1-2;Q9UHX1;E9PMU7 Poly(U)-binding-splicing factor PUF60 PUF E9PBF6;P20700 Lamin-B1 LMNB H0YDD4;P10515;F5H7M3;E9 PEJ4 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, DLAT P84077;P61204;F5H423;F5H 0C7 ADP-ribosylation factor 1;ADP-ribosylation factor 3 ARF1;ARF Q00341;Q ;H0Y394 Vigilin HDLBP P23246;P Splicing factor, proline- and glutamine-rich SFPQ Q ;Q ;Q92841;H3BLZ8;Q ;C9JMU5 Probable ATP-dependent RNA helicase DDX17 DDX Q ;Q ;Q ;Q12906;Q ;Q ;Q Interleukin enhancer-binding factor 3 ILF P S ribosomal protein S4, X isoform RPS4X Q9NRW7;F5H8K1;F5GYC3 Vacuolar protein sorting-associated protein 45 VPS P19105;O14950;J3QRS3 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B MYL12A;MYL12 B E9PKL9;Q13630;E9PP60;E9P LH9;E9PP14 E7EW34;Q13200;E9S3 GDP-L-fucose synthase TSTA S proteasome non-atpase regulatory subunit 2 PSMD P48449;P ;P Lanosterol synthase LSS Q ;Q02750 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K I3L4I0;Q96CP2;I3L1Y9 FLYWCH family member 2 FLYWCH P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA P17931;G3V3R6 Galectin-3 LGALS Q9P2X0;Q9P2X0-2 Dolichol-phosphate subunit 3 mannosyltransferase DPM S132

133 P26599;P ;P ;A6NLN1 Polypyrimidine tract-binding protein 1 PTBP P kda heat shock protein, HSPD P ;P14678;P ;J3QLE5;P63162;B3KVR1 Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N;Small nuclear ribonucleoprotein-associated protein SNRPB;SNRPN P50454;E9PR70;E9PPV6;E9P KH2 Serpin H1 SERPINH H0Y4R1;P12268;E7ETK5 Inosine-5-monophosphate dehydrogenase 2 IMPDH O14745;J3QRP6 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 SLC9A3R F5H1L4;E7ENA2;Q9NNW7-2;F5H2V0;D3YTF9;Q9NNW7; E7EWK1;Q9NNW7-3;D3YTF8 Thioredoxin reductase 2, TXNRD E5RI99;P S ribosomal protein L30 RPL O43175;Q5SZU1 D-3-phosphoglycerate dehydrogenase PHGDH P13639 Elongation factor 2 EEF P ;E9PKP7;P17480 Nucleolar transcription factor 1 UBTF E7EPB3;P S ribosomal protein L14 RPL P26583;D6R9A6 High mobility group protein B2 HMGB Q9NSD9;F5H6Y1 Phenylalanine--tRNA ligase beta subunit FARSB P10599;P Thioredoxin TXN P S ribosomal protein S28 RPS Q ;Q16555 Dihydropyrimidinase-related protein 2 DPYSL Q9H307;Q9H307-2 Pinin PNN B4DJV2;O75390;H0YIC4 Citrate synthase;citrate synthase, CS P19623;K7EKM4;K7ESL0 Spermidine synthase SRM Q9BTZ2-8;Q9BTZ2-4;Q9BTZ2 Dehydrogenase/reductase SDR family member 4 DHRS O95470 Sphingosine-1-phosphate lyase 1 SGPL P26641;B4DTG2 Elongation factor 1-gamma EEF1G Q16543;K7EQA9;K7EKQ2 Hsp90 co-chaperone Cdc37;Hsp90 cochaperone Cdc37, N-terminally processed CDC P ;P ;P00390;P ;P Glutathione reductase, GSR Q8N163-2;Q8N163 DBIRD complex subunit KIAA1967 KIAA P kda glucose-regulated protein HSPA O ;O96011 Peroxisomal membrane protein 11B PEX11B P ;P49419;F8VS02;P ;P Alpha-aminoadipic dehydrogenase S133 semialdehyde ALDH7A P S ribosomal protein L10a RPL10A

134 P80404;H3BRN4;H3BNQ7 4-aminobutyrate aminotransferase, ABAT P00918 Carbonic anhydrase 2 CA P ;P42126;H3BS70;Q96DC0 Enoyl-CoA delta isomerase 1, ECI1;DCI O ;O95671;E7ER97;O N-acetylserotonin protein O-methyltransferase-like ASMTL Q8NC51-4;Q8NC51-3;Q8NC51-2;Q8NC51 Plasminogen activator inhibitor 1 RNAbinding protein SERBP P07814;V9GYZ6 Bifunctional glutamate/proline--trna ligase;glutamate--trna ligase;proline--trna ligase EPRS Q13435;E9PPJ0 Splicing factor 3B subunit 2 SF3B P41091;Q2VIR3;Q2VIR3-2;F8W810 Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein EIF2S3;EIF2S3L P46109 Crk-like protein CRKL Q ;Q00325;F8VVM2 Phosphate carrier protein, SLC25A Q96HE7 ERO1-like protein alpha ERO1L B4DQJ8;P52209;F5H7U0;K7E M49;K7EMN2 6-phosphogluconate decarboxylating dehydrogenase, PGD P07900;P ;Q86U12 Heat shock protein HSP 90-alpha HSP90AA O ;O ;O75369;O ;O ;O ;E7EN95;O ;O ;O Filamin-B FLNB P61313;E7EQV9;E7EX53;E7 ENU7;P S ribosomal protein L15;Ribosomal protein L15 RPL E7EP00;G5EA31;P53992 Protein transport protein Sec24C SEC24C P08758;D6RBL5;D6RBE9 Annexin A5;Annexin ANXA F6S6P2;P ;P ;P ;B0UX83;P46379;P Large proline-rich protein BAG6 BAG D6RFM5;E9PBJ5;P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, SDHA P27361;E9PBK7;P ;E9PQW4;P ;E9PJF0;B3KR49 K7ENL3;P ;P40763;G8JLH9 Mitogen-activated protein kinase 3 MAPK Signal transducer and activator of transcription 3 STAT B4DUR8;P ;P49368 T-complex protein 1 subunit gamma CCT Q9NVT9;B4E2W7;E5RJ86 Armadillo repeat-containing protein 1 ARMC P51570;B4E1G6 Galactokinase GALK Q3ZCM7;F5H0I4;Q5SQY0 Tubulin beta-8 chain TUBB S134

135 H7C1T3;C9J050;P49585;C9J EJ2;H7BZN1;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3;C9J2E1 Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B YT1A;YT1 B P22626;P P24534;F8WF65;F2Z2G2;C9J ZW3 Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B Elongation factor 1-beta EEF1B P31939;F5GWY2;P ;H7C1S2 Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarbox amide formyltransferase;imp cyclohydrolase ATIC B4E241;P84103 Serine/arginine-rich splicing factor 3 SFRS3;SRSF P05783;F8VZY9 Keratin, type I cytoskeletal 18 KRT Q9HD45;Q5TB53 Transmembrane 9 superfamily member 3 TM9SF P30153;F5H3X9;B3KQV6;C9J 9C1 Serine/threonine-protein phosphatase 2A 65 kda regulatory subunit A alpha isoform PPP2R1A P21291;E9PS42;E9PND2;E9 PP21 Cysteine and glycine-rich protein 1 CSRP O43390;O ;O ;B4DT28;S4R3J4;E7ETM7 Heterogeneous nuclear ribonucleoprotein R HNRNPR;HNRP R P14868;Q68CR9 Q ;Q15029;K7EJ81 Aspartate--tRNA ligase, cytoplasmic 116 kda U5 small nuclear ribonucleoprotein component DARS;DKFZp78 1B EFTUD F5H1Z6;F5H8H3;Q9Y365;F5 H8G1;F5GY11;F5H0V7;H0YG A9;H0YFF3;F5GWK5;H0YH17 TP-like protein STARD H0Y6E7;H3BT71;P38159;P ;H3BR27;P RNA-binding motif protein, X chromosome;rna-binding motif protein, X chromosome, N-terminally processed RBMX P63261 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N- terminally processed ACTG P ;P21964;E7EMS6 Catechol O-methyltransferase COMT Q15233;Q ;C9JYS8;C9IZL7;H7C367 Q9Y3Q3;G3V1J9;F5H4M7;Q9 Y3Q3-2 Non-POU domain-containing octamerbinding protein Transmembrane emp24 domain-containing protein 3 NONO TMED Q9Y696 Chloride intracellular channel protein 4 CLIC Q9BSJ8;Q9BSJ8-2 Extended synaptotagmin-1 ESYT P10768;H7BZT7 S-formylglutathione hydrolase ESD P23526;P Adenosylhomocysteinase AHCY Q96CN7 Isochorismatase domain-containing protein 1 ISOC S135

136 P40939 Trifunctional enzyme subunit alpha, ;Long-chain enoyl-coa hydratase;long chain 3-hydroxyacyl-CoA dehydrogenase HADHA O15294;O ;O ;O UDP-N-acetylglucosamine--peptide N- acetylglucosaminyltransferase 110 kda subunit OGT P33991 DNA replication licensing factor MCM4 MCM P60866;P ;E5RJX2;E5RIP1 40S ribosomal protein S20 RPS P52597 Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed HNRNPF P17987;E7EQR6;F5H282;E7E RF2 T-complex protein 1 subunit alpha TCP P62249;M0R210;M0R3H0 40S ribosomal protein S16 RPS Q9UL25 Ras-related protein Rab-21 RAB O14929;O Histone acetyltransferase type B catalytic subunit HAT P11387 DNA topoisomerase 1 TOP Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H Q96I24 Far upstream element-binding protein 3 FUBP Q8IY81 pre-rrna processing protein FTSJ3 FTSJ Q96RS6;Q96RS6-3;Q96RS6-2 O ;O ;O ;O ;O95197;B7Z4M1;O ;O NudC domain-containing protein 1 NUDCD Reticulon-3 RTN B4DLW8;P17844;J3KTA4 Probable ATP-dependent RNA helicase DDX5 DDX P S ribosomal protein L34 RPL P ;P62995;H7BXF3;H7C2L4 Transformer-2 protein homolog beta TRA2B P60953;E7ETU3 Cell division control protein 42 homolog CDC P68133;P68032;Q5T8M8;A6N L76;P63267;P62736 Actin, alpha skeletal muscle;actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;actin, aortic smooth muscle ACTA1;ACTC1; ACTG2;ACTA P ;P06748;P Nucleophosmin NPM P31943;G8JLB6;E9Y7;D6 RBM0;D6RIT2;D6RIU0;E7EQ J0;D6RAM1;E5RGV0;D6R9T0 ;D6RFM3;E7EN40;D6RDU3;D 6RJ04;D6RIH9;H0YB39 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed HNRNPH P31948;F5H0T1;G3XAD8 Stress-induced-phosphoprotein 1 STIP E7EUI8;E7EM57 Glucose-6-phosphate 1-dehydrogenase G6PD S136

137 O95881 Thioredoxin domain-containing protein 12 TXNDC Q9NR45 Sialic acid synthase NANS S4R3G0;Q13242;H0YIB4 Serine/arginine-rich splicing factor 9 SRSF P ;P34897;P ;B4DLV4;H0YIZ0;G3V2Y4 Serine hydroxymethyltransferase, ;Serine hydroxymethyltransferase SHMT H7C463;C9J406;B9A067;Q ;Q ;Q ;Q16891 Mitochondrial inner membrane protein IMMT Q96AB3;Q96AB3-2;Q96AB3-3;K7EKW4;K7ENV7 Isochorismatase domain-containing protein 2, ISOC Q5T7C4;Q5T7C6;P09429;Q5 T7C0 P50395;E7EU23;P ;Q5SX87 High mobility group protein B1 HMGB Rab GDP dissociation inhibitor beta GDI O60701;O ;O UDP-glucose 6-dehydrogenase UGDH P13804;P ;H0YLU7;H0YL12;H0YK49;H 0YNX6;H0YKF0 O75643 Electron transfer flavoprotein subunit alpha, U5 small nuclear ribonucleoprotein 200 kda helicase ETFA SNRNP P18031;B4DSN5 Tyrosine-protein phosphatase non-receptor type 1;Tyrosine-protein phosphatase nonreceptor type PTPN H3BRV0;Q99613;B5ME19 Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein EIF3C;EIF3CL O15269 Serine palmitoyltransferase 1 SPTLC F5H801;Q ;Q02218;E9PDF2;E9R7;E 9PFG7 2-oxoglutarate dehydrogenase, OGDH P62854;Q5JNZ5 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 RPS26;RPS26P E9PD78;P23921;E9PL69;F5H 861 Ribonucleoside-diphosphate reductase;ribonucleoside-diphosphate reductase large subunit RRM B1AHB1;P33992 DNA replication licensing factor MCM5 MCM Q12905 Interleukin enhancer-binding factor 2 ILF Q16531;F5GY55 DNA damage-binding protein 1 DDB B7Z1R5;P38606 V-type proton ATPase catalytic subunit A ATP6V1A P42765;K7EME0 3-ketoacyl-CoA thiolase, ACAA Q9Y277;Q9Y277-2;F5H740;E5RJN6;E5RHZ6 Voltage-dependent anion-selective channel protein 3 VDAC S137

138 Q6P2Q9;I3L0J9 Pre-mRNA-processing-splicing factor 8 PRPF Q9BSH5 Haloacid dehalogenase-like hydrolase domain-containing protein 3 HDHD Q14566 DNA replication licensing factor MCM6 MCM Q ;Q92688;Q5T6W8 Acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B O00299 Chloride intracellular channel protein 1 CLIC P04899;P ;B4E2X5;P ;P ;B3KTZ0;F5GZL8 Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI J3KNU8;Q02252;G3V4Z4 Methylmalonate-semialdehyde dehydrogenase [acylating], ALDH6A P49327 Fatty acid synthase;[acyl-carrier-protein] S- acetyltransferase;[acyl-carrier-protein] S- malonyltransferase;3-oxoacyl-[acyl-carrierprotein] synthase;3-oxoacyl-[acyl-carrierprotein] reductase;3-hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl-[acylcarrier-protein] reductase;oleoyl-[acylcarrier-protein] hydrolase FASN P ;P ;P31942;P ;P ;P ;B4DHY1 Heterogeneous nuclear ribonucleoprotein H3 HNRNPH O95817;C9JFK9 BAG family molecular chaperone regulator 3 BAG Q9NZT2-2;Q9NZT2 Opioid growth factor receptor OGFR P04843;B7Z4L4 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 RPN Q13085;Q ;Q ;Q Q9BUQ8 Acetyl-CoA carboxylase 1;Biotin carboxylase ACACA Probable ATP-dependent RNA helicase DDX23 DDX P05141 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed SLC25A P62136;P ;E9PMD7;P Serine/threonine-protein phosphatase PP1- alpha catalytic subunit;serine/threonineprotein phosphatase PPP1CA S138

139 P63092;P ;Q5JWF2;P ;P ;Q5JWF2-2 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAS Q8IXI1;H3BST5;I3L2C6;Q8IXI 1-2 O ;O ;O ;O60506;O Mitochondrial Rho GTPase 2 RHOT Heterogeneous nuclear ribonucleoprotein Q SYNCRIP G3V279;P84090 Enhancer of rudimentary homolog ERH K7EMV3;B4DEB1;K7EK07;Q7 1DI3;Q16695;P84243;P68431; K7ES00;K7EP01;Q6NXT2 Histone H3;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1;Histone H3.3C H3F3B;H3F3A;H IST2H3A;HIST3 H3;HIST1H3A;H 3F3C O95994;Q4JM47;B5MC07;C9 J3E2;H7C3Z9 P61247;D6RG13;D6RAT0;F5 H4F9;D6RB09;E9PFI5;H0Y8L 7;H0Y9Y4;D6RAS7;D6R9B6 Anterior gradient protein 2 homolog AGR S ribosomal protein S3a RPS3A P61978;P ;Q5T6W1 Heterogeneous nuclear ribonucleoprotein K HNRNPK Q13838;Q ;F8VQ10;Q5STU3;B4DP52;F 6WLT2;F6S4E6;F6UN21;F6T RA5;F6UJC5 Spliceosome RNA helicase DDX39B DDX39B Q9Y2X3 Nucleolar protein 58 NOP Q9NTK5;J3KQ32;Q9NTK5-2;Q9NTK5-3 Obg-like ATPase 1 OLA O ;Q5T8U5;O15260;B7Z6A4 Surfeit locus protein 4 SURF Q15365 Poly(rC)-binding protein 1 BP P30042;H7C1F6;H7C2G3;P ES1 protein homolog, C21orf P ;P21333;Q5HY54 Filamin-A FLNA P ;P ;P15170;H3BR35;Q8IYD1 Eukaryotic peptide chain release factor GTPbinding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B GSPT1;GSPT Q9BS26 Endoplasmic reticulum resident protein 44 ERP Q9HCC0;Q9HCC0-2;D6RD67 Methylcrotonoyl-CoA carboxylase beta chain, MCCC O ;O95831;O Apoptosis-inducing factor 1, AIFM P38646 Stress-70 protein, HSPA O75396 Vesicle-trafficking protein SEC22b SEC22B Q12907;D6RBV2;D6RIU4;D6 RDX1 Vesicular integral-membrane protein VIP36 LMAN E9PIE4 Mitochondrial carrier homolog 2 MTCH S139

140 B4DWW1;P40616;F8VYN9;B4 DZG7 Q9NZM1-6;Q9NZM1-3;C9JCN0;Q9NZM1;F8W8J4; Q9NZM1-2;H0YD14;Q9NZM1-5 ADP-ribosylation factor-like protein 1 ARL Myoferlin MYOF O75083;D6RD66 WD repeat-containing protein 1 WDR Q9UBM7;E9PM00 7-dehydrocholesterol reductase DHCR Q ;Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU P ;P ;P11177 Pyruvate dehydrogenase E1 component subunit beta, PDHB B4DP21;B4DP11;Q15185;B4D HP2 Prostaglandin E synthase 3 PTGES Q14694;Q ;Q Ubiquitin carboxyl-terminal hydrolase 10 USP Q92499 ATP-dependent RNA helicase DDX1 DDX P60903 Protein S100-A10 S100A O00567;H0Y653;H0YDU4 Nucleolar protein 56 NOP M0R117;Q02543;M0R3D6;M0 R1A7;M0R0P7 P12236;I7HJJ0;P S ribosomal protein L18a RPL18A ADP/ATP translocase 3;ADP/ATP translocase 1 SLC25A6;SLC2 5A Q08211 ATP-dependent RNA helicase A DHX P53618;E9PP73 Coatomer subunit beta COPB O14980 Exportin-1 XPO P07237;H7BZ94;F5H8J2;H0Y 3Z3 Protein disulfide-isomerase P4HB P22234;E9PBS1;P ;D6RF62 Multifunctional protein ADE2;Phosphoribosylaminoimidazolesuccinocarboxamide synthase;phosphoribosylaminoimidazole carboxylase PAICS G5EA52;P30101 Protein disulfide-isomerase A3 PDIA O ;O ;O75367;D6RCF2;B4DJC3 Core histone macro-h2a.1;histone H2A H2AFY Q9NY27;Q9NY27-3;C9IZ04;Q9NY27-2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R Q14258 E3 ubiquitin/isg15 ligase TRIM25 TRIM P62333;H0YJC0 26S protease regulatory subunit 10B PSMC Q13263;Q Transcription intermediary factor 1-beta TRIM P60709;Q5T8M7 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N- terminally processed ACTB;ACTA O75131;E5RG68;E5RHZ0;H0 YB26 Copine-3 CPNE Q99497;K7ELW0;K7EN27 Protein DJ-1 PARK Q9H3N1 Thioredoxin-related transmembrane protein 1 TMX P16401 Histone H1.5 HIST1H1B S140

141 Q8WUY1 Protein THEM6 THEM P ;P54886 Delta-1-pyrroline-5-carboxylate synthase;glutamate 5-kinase;Gammaglutamyl phosphate reductase ALDH18A P09467 Fructose-1,6-bisphosphatase 1 FBP P22102;P ;C9JBJ1;C9JTV6;F8WD69 Trifunctional purine biosynthetic protein adenosine-3;phosphoribosylamine--glycine ligase;phosphoribosylformylglycinamidine cyclo-ligase;phosphoribosylglycinamide formyltransferase GART Q9NZB2-4;Q9NZB2;Q9NZB2-6 Constitutive coactivator of PPAR-gamma-like protein 1 FAM120A E9PLK3;P55786;B7Z463 Puromycin-sensitive aminopeptidase NPEPPS Q9P258 Protein RCC2 RCC P22314 Ubiquitin-like modifier-activating enzyme 1 UBA B7Z817;Q15392 Delta(24)-sterol reductase DHCR P30084 Enoyl-CoA hydratase, ECHS Q96DI7;Q9NSS8;B4DQJ1 U5 small nuclear ribonucleoprotein 40 kda protein SNRNP40;DKFZ p434d Q07020;J3QQ67;F8VWC5;G3 V203;H0YHA7;F8VYV2;F8VU A6 P39023;H7C422;G5E9G0;H7 C3M2;B5MCW2 Q13185;C9JMM0;B8ZZ43;S4 R2Y4 Q9UM54-5;Q9UM54-2;Q9UM54-6;Q9UM54-4;Q9UM54-1;E7EW20;Q9UM54 60S ribosomal protein L18 RPL S ribosomal protein L3 RPL Chromobox protein homolog 3 CBX Unconventional myosin-vi MYO P61006;B4DEK7 Ras-related protein Rab-8A RAB8A Q9NX63;C9JRZ6;G3V1K1;F8 WAR4 domain- Coiled-coil-helix-coiled-coil-helix containing protein 3, CHCHD P56545;Q5SQP8;P C-terminal-binding protein 2 CTBP D6RCP9;P27707;D6RFG8 Deoxycytidine kinase DCK P62241;Q5JR95 40S ribosomal protein S8 RPS P19338;H7BY16 Nucleolin NCL Q9Y678 Coatomer subunit gamma-1 COPG Q5JP53;P07437;Q5ST81 Tubulin beta chain TUBB P42704 Leucine-rich PPR motif-containing protein, LRPPRC P26373;J3QSB4;P S ribosomal protein L13 RPL P23528;G3V1A4;E9PP50;E9P K25;E9PQB7 P ;P ;P ;P78347 Cofilin-1 CFL General transcription factor II-I GTF2I S141

142 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed FKBP Q13509;A8K854 Tubulin beta-3 chain TUBB Q13148;B1AKP7;G3V162;K7 EJM5;K7EN94;B4DJ45 TAR DNA-binding protein 43 TARDBP P62140;E7ETD8 Serine/threonine-protein phosphatase PP1- beta catalytic subunit PPP1CB Q14247 Src substrate cortactin CTTN P53007 Tricarboxylate transport protein, SLC25A Q9BR76;F5H390;E7EW44 Coronin-1B;Coronin CORO1B Q ;Q01081;Q Splicing factor U2AF 35 kda subunit U2AF E9PKG1;Q ;Q ;Q ;Q99873;H7C2I1;E9PIX6;E9 PQ98;E9PNR9;H0YDE4 Protein arginine N-methyltransferase 1 PRMT P52907 F-actin-capping protein subunit alpha-1 CAPZA Q07666;Q ;Q KH domain-containing, RNA-binding, signal transduction-associated protein 1 KHDRBS Q96AG4 Leucine-rich repeat-containing protein 59 LRRC P24468;P ;P ;P10589 COUP transcription factor 2;COUP transcription factor 1 NR2F2;NR2F Q ;Q ;Q ;Q10567;C9J1E7 AP-1 complex subunit beta-1 AP1B Q9Y5B9 FACT complex subunit SPT16 SUPT16H K7EIN2;Q9BRJ7;K7ENA3 Protein syndesmos NUDT16L Q8NDH3;Q8NDH3-5;Q8NDH3-4;Q8NDH3-2;Q8NDH3-3 Probable aminopeptidase NPEPL1 NPEPL P48735;B4DFL2;B4DSZ6 Isocitrate dehydrogenase [NADP], ;Isocitrate dehydrogenase [NADP] IDH P53004 Biliverdin reductase A BLVRA Q99714;Q ;Q5H928 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B P61158;B4DXW1;F5H3P5 Actin-related protein 3 ACTR Q96N66-3;Q96N66;Q96N66-2 Lysophospholipid acyltransferase 7 MBOAT P43243;A8MXP9;D6REM6;D6 R991 O ;O15231;O ;O ;O ;O ;H0Y704;J3KNL4;H7BZT5;O ;O O43747;O ;J3KQU9;B3KXW5 Q14697;Q ;F5H6X6;E9PKU7 Matrin-3 MATR Zinc finger protein 185 ZNF AP-1 complex subunit gamma-1 AP1G Neutral alpha-glucosidase AB GANAB S142

143 Q04760;Q Lactoylglutathione lyase GLO Q3SXM5;Q3SXM5-2 Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL O ;O75608;E5RGR0 Acyl-protein thioesterase 1 LYPLA Q9UMS4 Pre-mRNA-processing factor 19 PRPF E7EUT8;Q12874 Splicing factor 3A subunit 3 SF3A O00264;B7Z1L3 Membrane-associated progesterone receptor component 1 PGRMC P ;P ;P ;P22307;P ;P Non-specific lipid-transfer protein SCP Q9BQ69 O-acetyl-ADP-ribose MACROD1 deacetylase MACROD P62266;D6RD47 40S ribosomal protein S23 RPS O ;O ;O14979 Heterogeneous nuclear ribonucleoprotein D- like HNRPDL P55795 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed HNRNPH Q9H993;F5GZY1 UPF0364 protein C6orf211 C6orf Q86VP6;Q86VP6-2 B4DIV7;Q ;Q12765;Q Cullin-associated NEDD8-dissociated protein 1 CAND Secernin-1 SCRN Q92466;Q ;Q DNA damage-binding protein 2 DDB J3KSM3;J3KRR2;J3QKR3;P Proteasome subunit beta type-3 PSMB P13489;H0YCR7 Ribonuclease inhibitor RNH Q9P0L0;Q9P0L0-2 Vesicle-associated membrane proteinassociated protein A VAPA Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Coronin-1C;Coronin CORO1C Q ;F8WJN3;Q16630;Q Cleavage and polyadenylation specificity factor subunit 6 CPSF P ;P50213;H0YMU3;B7Z9J8;H 0YL72;H0YLI6 P29401;P ;B4E022;E9PFF2 H7C3A1;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 P15880;H0YEN5;E9PQD7;E9 PMM9 Isocitrate dehydrogenase [NAD] subunit alpha, IDH3A Transketolase TKT Serrate RNA effector molecule homolog SRRT S ribosomal protein S2 RPS Q9H0D6-2;B4DZC3;Q9H0D6 5-3 exoribonuclease 2 XRN P78371;P ;F5GWF6;F8VQ14 T-complex protein 1 subunit beta CCT P02792 Ferritin light chain FTL O95716 Ras-related protein Rab-3D RAB3D Q96G23;Q5SZE1;H0YLQ6;Q5 SZE6;H0YNU7 Ceramide synthase 2 CERS S143

144 P ;P ;P55060;B4DUC5 Exportin-2 CSE1L B4DUR9;O95433;H0YJ63;G3 V438;H0YJG7 Activator of 90 kda heat shock protein ATPase homolog 1 AHSA Q9UQ35 Serine/arginine repetitive matrix protein 2 SRRM Q9BWD1;B7Z233 Acetyl-CoA acetyltransferase, cytosolic ACAT H0Y8G5;Q ;Q14103;H0YA96;Q ;B4DTC3;Q ;D6RAF8;D6RF44;D6RBQ9 Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Q6YN16;Q6YN16-2 Hydroxysteroid dehydrogenase-like protein 2 HSDL O60341;O ;F6S0T5 Lysine-specific histone demethylase 1A KDM1A J3KNQ3;Q9UNM6;Q9UNM6-2;H0YD73;E9PL38 26S proteasome non-atpase regulatory subunit 13 PSMD Q9NQR4;H7C579 Omega-amidase NIT2 NIT P62979;J3QS39;J3QTR3;F5H 6Q2;P62987;F5GYU3;F5H2Z3 ;F5H265;B4DV12;F5H388;F5 H747;F5GXK7;J3QKN0;P0CG 47;Q96C32;F5H041;P0CG48; M0R1V7;M0R1M6;M0R2S1;J 3QLP7;J3QRK5 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin;Polyubiquitin- C;Ubiquitin RPS27A;UBB;U BC;UBA52;UBB P Q ;Q13247 Serine/arginine-rich splicing factor 6 SRSF Q13228;A6PVW9;Q ;A6PVX1;Q ;H0Y532 Selenium-binding protein 1 SELENBP Q99880;Q99879;Q99877;Q93 079;Q5QNW6;P62807;P5887 6;P57053;O60814;Q5QNW6-2;U3KQK0;B4DR52 Histone H2B type 1-L;Histone H2B type 1- M;Histone H2B type 1-N;Histone H2B type 1- H;Histone H2B type 2-F;Histone H2B type 1- C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B HIST1H2BL;HIS T1H2BM;HIST1 H2BN;HIST1H2 BH;HIST2H2BF; HIST1H2BC;HIS T1H2BD;H2BFS ;HIST1H2BK P62753;A2A3R5 40S ribosomal protein S6 RPS F5GXC8;Q9P2R7-2;Q9P2R7;Q5T9Q5;F5H5G8 Succinyl-CoA ligase [ADP-forming] subunit beta, SUCLA P02794;G3V192;G3V1D1 Ferritin heavy chain;ferritin FTH C9J8Q5;P51649;P ;F5H328 Succinate-semialdehyde dehydrogenase, ALDH5A P ;P53396;B4E3P0 ATP-citrate synthase ACLY E9PK01;P29692;P ;E9PRY8;P ;E9PPR1;E9PL12;E9PQ49;E 9PI39;E9PMW7;E9PIZ1;E9PL 71;H0YCK7;E9PQZ1;P Elongation factor 1-delta EEF1D S144

145 J3QQT2;J3KRX5;P18621;P ;P ;J3QLC8;J3QS96;J3KRB3 60S ribosomal protein L17 RPL P05455;E9PFL9;E7ERC4 Lupus La protein SSB Q8WVC2;P63220;Q9BYK1 40S ribosomal protein S21 RPS Q8NBX0 Saccharopine oxidoreductase dehydrogenase-like SCCPDH P21266 Glutathione S-transferase Mu 3 GSTM Q5JR08;P08134;E9PQH6;P Rho-related GTP-binding protein RhoC;Transforming protein RhoA RHOC;RHOA Q7Z434;Q7Z434-4 Mitochondrial antiviral-signaling protein MAVS O75533 Splicing factor 3B subunit 1 SF3B P14866;P ;M0QXS5 Heterogeneous nuclear ribonucleoprotein L HNRNPL Q9BXW7-2;Q9BXW7;A8MYZ9 Cat eye syndrome critical region protein 5 CECR G5EA52;P30101 Protein disulfide-isomerase A3 PDIA Q1KMD3;H3BQZ7 Heterogeneous nuclear ribonucleoprotein U- like protein 2 HNRNPUL2;hC G_ Q ;Q ;Q15067 Peroxisomal acyl-coenzyme A oxidase 1 ACOX P ;P62993 Growth factor receptor-bound protein 2 GRB B4DPJ8;P40227;P T-complex protein 1 subunit zeta CCT6A O96008 Mitochondrial import receptor subunit TOM40 homolog TOMM Q96D46;C9JA08 60S ribosomal export protein NMD3 NMD Q ;Q92900 Regulator of nonsense transcripts 1 UPF Q86UY0;Q8NBS9;Q8NBS9-2 Thioredoxin domain-containing protein 5 TXNDC Q9NZ01;B3KSQ1 Very-long-chain enoyl-coa reductase TECR P02545;P ;P ;P Prelamin-A/C;Lamin-A/C LMNA P37837;F2Z393 Transaldolase TALDO Q06323;H0YNE3;Q Proteasome activator complex subunit 1 PSME Q9BUJ2-4;B7Z4B8;Q9BUJ2-2;Q9BUJ2;M0R3F1;Q9BUJ2-3;M0QYZ0 Heterogeneous nuclear ribonucleoprotein U- like protein 1 HNRNPUL P13667 Protein disulfide-isomerase A4 PDIA Q9NY33-4;Q9NY33;G3V1D3;G3V180;E 9PQ14 B7Z254;Q15084;F8WA83;B5 MCQ5;Q P09110;C9JDE9;H7C131;P Dipeptidyl peptidase 3 DPP Protein disulfide-isomerase A6 PDIA ketoacyl-CoA thiolase, peroxisomal ACAA S145

146 P54136;P ;F5H3T8 Arginine--tRNA ligase, cytoplasmic RARS Q99805 Transmembrane 9 superfamily member 2 TM9SF Q6NUK1;Q6NUK1-2 Calcium-binding carrier protein SCaMC-1 SLC25A P61966;H7C1E4;P AP-1 complex subunit sigma-1a AP1S P25205;B4DWW4;J3KQ69 DNA replication licensing factor MCM3 MCM P68371;P04350 Tubulin beta-4b chain;tubulin beta-4a chain TUBB4B;TUBB4 A Q8TEX9;Q8TEX9-2;H0YN14;H0YN07;H0YMR4 Importin-4 IPO P50990;B4DEM7;B4DQH4 T-complex protein 1 subunit theta CCT P43304;P ;F8W6E4 Glycerol-3-phosphate dehydrogenase, GPD P11586;F5H2F4 C-1-tetrahydrofolate synthase, cytoplasmic;methylenetetrahydrofolate dehydrogenase;methenyltetrahydrofolate cyclohydrolase;formyltetrahydrofolate synthetase;c-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed MTHFD D6R9P3;D6RD18;Q ;D6RBZ0;Q ;Q ;Q99729 Heterogeneous nuclear ribonucleoprotein A/B HNRNPAB P36578;H3BM89 60S ribosomal protein L4 RPL P46776;E9PLL6;E9PJD9 60S ribosomal protein L27a RPL27A O94826 Mitochondrial import receptor subunit TOM70 TOMM70A P24752 Acetyl-CoA acetyltransferase, ACAT Q ;Q ;Q ;E7EX73;Q ;E9PGM1;Q ;E7EUU4;Q04637;Q ;Q Eukaryotic translation initiation factor 4 gamma 1 EIF4G Q9UL46;H0YM70 Proteasome activator complex subunit 2 PSME Q96CW1-2;Q96CW1;E9PFW3;C9JJ47 AP-2 complex subunit mu AP2M O15143 Actin-related protein 2/3 complex subunit 1B AR1B G3V0E5;P02786;F5H6B1 Transferrin receptor protein 1;Transferrin receptor protein 1, serum form TFRC B4DK69;P52895;S4R3P0;Q04 828;H0Y804 Aldo-keto reductase family 1 member C2 AKR1C2;AKR1C S146

147 P35221;P ;G3XAM7;F8W845;P Catenin alpha-1 CTNNA Q ;Q ;Q15366;Q ;B4DLC0;H3BRU6;G3V0E8; F8VZX2;B4DXP5;Q ;Q ;F8VXH9;F8W0G4 Poly(rC)-binding protein 2 BP P10644;K7EM13;K7ER48;K7 EPB2 camp-dependent protein kinase type I-alpha regulatory subunit;camp-dependent protein kinase type I-alpha regulatory subunit, N- terminally processed PRKAR1A Q ;Q ;Q ;Q01105 Protein SET SET P00367;B4DGN5;B3KV55;P Glutamate dehydrogenase 1, ;Glutamate dehydrogenase;glutamate dehydrogenase 2, GLUD1;GLUD O ;O00267 Transcription elongation factor SPT5 SUPT5H O60264 SWI/SNF-related matrix-associated actindependent regulator of chromatin subfamily A member 5 SMARCA Q9P035;H3BPZ1;H3BS72;B4 DRF4 Very-long-chain (3R)-3-hydroxyacyl-[acylcarrier protein] dehydratase 3 PTPLAD P04181;P Ornithine aminotransferase, ;Ornithine aminotransferase, hepatic form;ornithine aminotransferase, renal form OAT K7ELQ9;Q6UW68;K7EM09;K 7EPR0 P10620;F5GX73;F5H613;F5H 7F6;F5H6X2;P ;F5H760 Transmembrane protein 205 TMEM Microsomal glutathione S-transferase 1 MGST P17858;P phosphofructokinase, liver type PFKL G3V1B3;M0R181;P S ribosomal protein L21 RPL P ;P ;F5GZS6;P08195;J3KPF3;P F2 cell-surface antigen heavy chain SLC3A A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3;A0MZ66-7;A0MZ66-2 Shootin-1 KIAA P14174 Macrophage migration inhibitory factor MIF I3L397;P63241;P ;I3L504;F8WCJ1;C9J7B5;C9 J4W5;Q9GZV4;Q6IS14 Eukaryotic translation initiation factor 5A- 1;Eukaryotic translation initiation factor 5A- 2;Eukaryotic translation initiation factor 5A-1- like EIF5A;EIF5A2;E IF5AL S147

148 O43143 Putative pre-mrna-splicing factor ATPdependent RNA helicase DHX15 DHX Q9ULA0;E7ETB3;E7EMB6;B9 ZVU2;F8WAN0;E7EPX3;C9JB E1 Aspartyl aminopeptidase DNPEP P30040;F8VY02 Endoplasmic reticulum resident protein 29 ERP Q9UJ70;H7C3G9;Q9UJ70-2;C9JEV6;H7C286 N-acetyl-D-glucosamine kinase NAGK P09382 Galectin-1 LGALS P30086 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide PEBP Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Histone-arginine methyltransferase CARM1 CARM O60313;E5KLK1;E5KLJ6;E5K LJ9;O ;E5KLJ5 Dynamin-like 120 kda protein, ;Dynamin-like 120 kda protein, form S1 OPA P36507 Dual specificity mitogen-activated protein kinase kinase 2 MAP2K P56537;B7ZBH1 Eukaryotic translation initiation factor 6 EIF P41250 Glycine--tRNA ligase GARS P S ribosomal protein L29 RPL P30405 Peptidyl-prolyl cis-trans isomerase F, ;Peptidyl-prolyl cis-trans isomerase PPIF Q13547;F5GXM1 Histone deacetylase 1 HDAC G5E972;P42167;P ;H0YJH7 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopoietin;thymopentin TMPO Q13162;H7C3T4 Peroxiredoxin-4 PRDX Q99575 Ribonucleases P/MRP protein subunit POP1 POP C9JIS1;C9JXA5;P62879;C9JZ N1;E7EP32;Q9HAV0 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;guanine nucleotide-binding protein subunit beta-4 GNB2;GNB P ;P ;F8W1A4;P54819;F8VY04;P ;G3V213;F8VZG5;P Adenylate kinase 2, ;Adenylate kinase 2,, N-terminally processed AK Q16186 Proteasomal ubiquitin receptor ADRM1 ADRM P62873;F6UT28;B1AKQ8;F6X 3N5 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB P42224;P ;J3KPM9 Signal transducer and activator of transcription 1-alpha/beta STAT Q92945;M0R0I5 Far upstream element-binding protein 2 KHSRP S148

149 O43252 Bifunctional 3-phosphoadenosine 5- phosphosulfate synthase 1;Sulfate adenylyltransferase;adenylyl-sulfate kinase PAPSS C9JXB8;C9JNW5;P S ribosomal protein L24 RPL G5E972;P42167;P ;H0YJH7 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopoietin;thymopentin TMPO J3QSV6;O76021;I3L3U9;I3L3 C4 Ribosomal L1 domain-containing protein 1 RSL1D P61962;E9Y4 DDB1- and CUL4-associated factor 7 DCAF Q96HS1-2;Q96HS1 Serine/threonine-protein PGAM5, phosphatase PGAM P ;B7Z856;P56159 GDNF family receptor alpha-1 GFRA Q14318;Q ;J3KQ73;Q Peptidyl-prolyl cis-trans isomerase FKBP8 FKBP B4DWZ5;O43772;C9JPE1 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A Q8TD06;H7C040;B5MC62 Anterior gradient protein 3 homolog AGR O75439;E7ERZ4;G3V0E4 Mitochondrial-processing peptidase subunit beta PMB Q9H4A4;A6NKB8 Aminopeptidase B RNPEP O95292 Vesicle-associated membrane proteinassociated protein B/C VAPB C9JD32;B9ZVP7;J3KT29;P P55884;P ;C9JQN7 60S ribosomal protein L23 RPL Eukaryotic translation initiation factor 3 subunit B EIF3B Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B Q969Z0;H7C4R5;C9IZN7 Protein TBRG4 TBRG P ;P27816;E7EVA0;P ;B4DSQ1;H0Y2V1;F8W9U4; P ;E9PGM5 Microtubule-associated 4;Microtubule-associated protein protein MAP P ;B4DFG0;P35659;D6RDA2 Protein DEK DEK Q9Y5M8;H7C4H2 Signal recognition particle receptor subunit beta SRPRB Q9H3U1-2;Q9H3U1 Protein unc-45 homolog A UNC45A Q13177;B1AKS5;O ;O75914;O ;O Serine/threonine-protein kinase PAK 2;PAK- 2p27;PAK-2p34;Serine/threonine-protein kinase PAK 3 PAK2;PAK P55957;P BH3-interacting domain death agonist;bh3- interacting domain death agonist p15;bh3- interacting domain death agonist p13;bh3- interacting domain death agonist p11 BID S149

150 O95340;E7ER89;O Bifunctional 3-phosphoadenosine 5- phosphosulfate synthase 2;Sulfate adenylyltransferase;adenylyl-sulfate kinase PAPSS Q9NP72;Q9NP72-2;Q9NP72-3;Q5W0J0 P51858;A8K8G0;P ;P B0QZ43;E5RHW4;O94905;O7 5477;O ;O Ras-related protein Rab-18 RAB Hepatoma-derived growth factor HDGF Erlin-2;Erlin-1 ERLIN1;ERLIN P S ribosomal protein S12 RPS O ;F5H6E2;O ;O00159 B4E1E9;Q9UBX3;Q9UBX3-2;B4DLN1;I3L1E8 Unconventional myosin-ic MYO1C Mitochondrial dicarboxylate carrier SLC25A O ;O ;O75400 Pre-mRNA-processing factor 40 homolog A PRPF40A Q9UBT2;K7EPL2 SUMO-activating enzyme subunit 2 UBA H3BQ53;Q9BQ70;H3BSS3;Q 9H384 P78417;Q5TA02;P ;P ;Q5TA01 Transcription factor 25 TCF Glutathione S-transferase omega-1 GSTO O ;O ;O ;O ;O00154;F5GWE2;O ;B4DUX0;K7EKP8;O Cytosolic acyl coenzyme A thioester hydrolase ACOT B0QY90;Q9Y262-2;Q9Y262;B0QY89 Eukaryotic translation initiation factor 3 subunit L EIF3L O ;O94906 Pre-mRNA-processing factor 6 PRPF F5GX77;Q9UI30;J3KNG5;F5 GYQ2;M0R242 trna methyltransferase 112 homolog TRMT Q15269 Periodic tryptophan protein 2 homolog PWP P ;P67775;P62714 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CA;PPP2C B A6NDG6 Phosphoglycolate phosphatase PGP Q92820 Gamma-glutamyl hydrolase GGH Q969X5-2;Q969X5 Endoplasmic reticulum-golgi intermediate compartment protein 1 ERGIC Q ;Q ;Q ;Q ;Q93084;Q ;Q Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 ATP2A P62263;H0YB22;E5RH77 40S ribosomal protein S14 RPS S150

151 P ;P ;P62834;P61224;F5H4H0;F5 GYH7;F5H077;F5GWU8;F5H 491;F5H0B7;F5H500;F5H6R7 ;F5H004;F5GYB5;F5GX62;P ;E7ESV4;F5H7Y6;A6NIZ1 Ras-related protein Rap-1b;Ras-related protein Rap-1A;Ras-related protein Rap-1blike protein RAP1B;RAP1A F2Z2Y4;O ;O00764;O Q9Y3D2;H0YE51 Pyridoxal kinase PDXK Methionine-R-sulfoxide reductase B2, MSRB B4DE85;Q9BUQ5;P48651 Phosphatidylserine synthase 1 PTDSS B4E1K7;Q9UJZ1 Stomatin-like protein 2, STOML Q9H9B4;D6RFI0 Sideroflexin-1 SFXN Q9UBQ7;U3KQ56;Q5T946 Glyoxylate reductase reductase/hydroxypyruvate GRHPR B4DFA2;I3L0N3;P46459 Vesicle-fusing ATPase NSF P49902;B7Z382 Cytosolic purine 5-nucleotidase NT5C H0Y612;Q9UPN9-2;Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM Q9NR30-2;Q9NR30 Nucleolar RNA helicase 2 DDX Q96A33-2;Q96A33 Coiled-coil domain-containing protein 47 CCDC Q9BWF3;E9PB51;Q9BQ04;Q 9BWF3-4;Q9BWF3-3;D6R9K7;J3QRR5;Q9BWF3-2 RNA-binding protein 4;RNA-binding protein 4B RBM4;RBM4B P ;P56134;P ;C9JJT5;P ;F5H4H2;C9JU26;G3V325 ATP synthase subunit f, ATP5J2;PTCD1; ATP5J2-PTCD P S acidic ribosomal protein P1 RPLP F5H442;Q99816;Q Tumor susceptibility gene 101 protein TSG Q16822;H0YML5;B4DW73;Q ;H0YM31 Phosphoenolpyruvate carboxykinase [GTP], K P28066 Proteasome subunit alpha type-5 PSMA F5H5Y3;Q9UHB9-4;Q9UHB9-2;Q9UHB9;Q9UHB9-3 H7BY36;Q ;C9JGE3;Q ;B0QYK0;Q ;Q01844;Q Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3;H3BUF6;H3BSK9 Signal recognition particle subunit SRP68 SRP RNA-binding protein EWS EWSR Ataxin-2-like protein ATXN2L Q8NFV4;Q8NFV4-4;Q8NFV4-6 F5GYC1;P28288;E7EUE1;P Alpha/beta hydrolase domain-containing protein 11 S151 ABHD ATP-binding cassette sub-family D member 3 ABCD Q15717;B4DVB8;M0QZR9 ELAV-like protein 1 ELAVL

152 Q15020;F8VV04;B7ZKM0 Squamous cell carcinoma antigen recognized by T-cells 3 SART Q9UNE7-2;Q9UNE7;H3BTA3;H3BUD0; H3BS86 Q7Z721;B4DLT4;P ;F6UYM1;P23443 E3 ubiquitin-protein ligase CHIP STUB Ribosomal protein S6 kinase beta-1 RPS6KB Q8N1G4 Leucine-rich repeat-containing protein 47 LRRC K7ENG2;P ;P26368 Splicing factor U2AF 65 kda subunit U2AF Q9NVP1 ATP-dependent RNA helicase DDX18 DDX G3V4X8;Q13573;G3V3A4 SNW domain-containing protein 1 SNW Q2TAY7;B4E3L0 WD40 repeat-containing protein SMU1 SMU Q8TDD1;Q8TDD1-2;F8VRX4 ATP-dependent RNA helicase DDX54 DDX P09874 Poly [ADP-ribose] polymerase 1 PARP J3KN29;O00233;F5H169;F5H 5V4;F5GX23;F8W7V8;O S proteasome non-atpase regulatory subunit 9 PSMD S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3T3;G3V3B0; Q9UKV3-3;Q9UKV3-2 Apoptotic chromatin condensation inducer in the nucleus ACIN Q15181;Q5SQT6 Inorganic pyrophosphatase PPA P55769;B1AHD1 NHP2-like protein 1;NHP2-like protein 1, N- terminally processed NHP2L Q9BV57;Q9BV57-2 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI O75844 CAAX prenyl protease 1 homolog ZMPSTE P49591;Q5T5C7 Serine--tRNA ligase, cytoplasmic SARS O95571;M0QXB5 E9PID8;P ;P33240;E7EWR4 Persulfide dioxygenase ETHE1, ETHE Cleavage stimulation factor subunit 2 CSTF P27694;I3L524;I3L2M5 Replication protein A 70 kda DNA-binding subunit;replication protein A 70 kda DNAbinding subunit, N-terminally processed RPA F5H2J3;Q96GC9;K7EL93;K7 EL74;K7ENU2;K7EK01;K7EM I0;K7ELS2 Vacuole membrane protein 1 VMP Q27J81-2;Q27J81 Inverted formin-2 INF P12004 Proliferating cell nuclear antigen NA Q14554 Protein disulfide-isomerase A5 PDIA Q71TU5;P48729;E5RG27;D6 RGE5;Q8N752;P Casein kinase I isoform alpha;casein kinase I isoform alpha-like CSNK1A1;CSN K1A1L P35998;B7Z5E2 26S protease regulatory subunit 7 PSMC S152

153 O ;O ;O94874 E3 UFM1-protein ligase 1 UFL Q9NR46;B7ZC38;B7ZC39;Q9 NR46-2 O75874;C9J4N6 Endophilin-B2 SH3GLB Isocitrate dehydrogenase [NADP] cytoplasmic IDH B4DN45;P31153 S-adenosylmethionine synthase;sadenosylmethionine synthase isoform type-2 MAT2A P30046;J3KQ18;B7Z522;A6N HG4;B5MC82 D-dopachrome decarboxylase;ddopachrome decarboxylase-like protein DDT;DDTL O95400 CD2 antigen cytoplasmic tail-binding protein 2 CD2BP F8W720;P49915 GMP synthase [glutamine-hydrolyzing] GMPS P35270 Sepiapterin reductase SPR P10619 Lysosomal protective protein;lysosomal protective protein 32 kda chain;lysosomal protective protein 20 kda chain CTSA P ;P35637;H3BPE7 RNA-binding protein FUS FUS Q9BQ52-4;G5E9D5;Q9BQ52;Q9BQ52-2;E7ES68 Zinc phosphodiesterase ELAC protein 2 ELAC Q5QPD0;Q5TFE4 5-nucleotidase domain-containing protein 1 NT5DC P48506 Glutamate--cysteine ligase catalytic subunit GCLC P ;P ;P28331;P ;B4DJ81;P NADH-ubiquinone oxidoreductase 75 kda subunit, NDUFS Q9Y2Z0-2;Q9Y2Z0;F5H5A9 Suppressor of G2 allele of SKP1 homolog SUGT O43719;Q5H919;Q5H918 HIV Tat-specific factor 1 HTATSF Q96LA8-2;Q96LA8 Protein arginine N-methyltransferase 6 PRMT P11498 Pyruvate carboxylase, Q9Y265;H7C4G5;E7ETR0;Q9 Y265-2;J3QLR1 A8MXL6;P ;P55735;B4DXJ1 RuvB-like 1 RUVBL Protein SEC13 homolog SEC Q06203;D6RCC8 Amidophosphoribosyltransferase PPAT P53597 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, SUCLG Q9HCY8 Protein S100-A14 S100A Q9UBV8 Peflin PEF Q ;Q99460 Q8TAQ2;Q8TAQ2-2;Q8TAQ2-3;F8VXC8 P ;P55265;P ;E7ENU4;P ;H0YCK3;P F5H365;Q15436;B3KXI2;F5H 6C4 26S proteasome non-atpase regulatory subunit 1 PSMD SWI/SNF complex subunit SMARCC2 SMARCC Double-stranded RNA-specific adenosine deaminase ADAR Protein transport protein Sec23A SEC23A S153

154 Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80 Basic leucine zipper and W2 domaincontaining protein 1 BZW A6PVN6;Q5T949;Q5T948;Q ;Q ;A6PVN5;Q15257;B4DZF8;A 6PVN7;A6PVN8;C9IZ76;A6PV N9 Serine/threonine-protein phosphatase 2A activator PPP2R H0YBR2;H0YBB3;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1;E5RI26 Epithelial splicing regulatory protein 1 ESRP P10253 Lysosomal alpha-glucosidase;76 kda lysosomal alpha-glucosidase;70 kda lysosomal alpha-glucosidase GAA Q15738;C9JDR0 Sterol-4-alpha-carboxylate 3- dehydrogenase, decarboxylating NSDHL I3L1P8;Q02978;Q P ;P05165;P Mitochondrial 2-oxoglutarate/malate carrier protein Propionyl-CoA carboxylase alpha chain, SLC25A CA P28072 Proteasome subunit beta type-6 PSMB F5H335;Q14152 Eukaryotic translation initiation factor 3 subunit A EIF3A Q52LJ0;Q52LJ0-2 Protein FAM98B FAM98B P78406;E9PPG9;E9PQ57 mrna export factor RAE Q9H0W8-2;Q9H0W8 Protein SMG9 SMG P ;P04844;Q5JYR4;Q5JYR7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN P27695;G3V5Q1;G3V3M6;G3 V5D9;G3V3C7 E5RHS5;E5RGA2;P60228;H0 YAW4 DNA-(apurinic or apyrimidinic site) lyase;dna-(apurinic or apyrimidinic site) lyase, Eukaryotic translation initiation factor 3 subunit E APEX EIF3E Q4VXZ8;Q9NUI1;Q9NUI1-3 Peroxisomal 2,4-dienoyl-CoA reductase DECR Q96RQ3;E9PHF7;E9PG35;G5 E9X5;F5GYT8 Methylcrotonoyl-CoA carboxylase subunit alpha, MCCC Q ;Q13724;C9J8D4 Mannosyl-oligosaccharide glucosidase MOGS Q9NZJ7-2;Q9NZJ7;Q5TDC2;H0Y8C3 Mitochondrial carrier homolog 1 MTCH P04040 Catalase CAT Q15517;G8JLG2 Corneodesmosin CDSN P31944 Caspase-14;Caspase-14 p19;caspase-14 subunit p10 subunit CASP S154

155 G5E9S8;Q ;G3V2E7;Q ;Q ;Q07866;F8W6L3;Q ;G3V3H3;Q ;Q ;Q ;G3V5R9;Q ;Q ;E7EVH7 Kinesin light chain 1 KLC P15924;P Desmoplakin DSP P14923 Junction plakoglobin JUP C9JEV0;P25311 Zinc-alpha-2-glycoprotein AZGP S155

156 Table S4: Competitive ABPP-DML with 200 nm AA-CW236 pretreatment followed by iodoacetamide alkyne treatment. Sequence Modifications Protein Ids Protein Names Gene Names PEP GNPVPILIH R TGQYSGIYDC AKK QHCAYTIAK CAVGLVDAVK GVLMYGPPG CGK NEEATKHLEC TK CMPTFQFFKK CGQYIQK NLSTFAVDGK DCK CQQLQQEYS R Oxidation (M); Oxidation (M); P16455 Q6NUK1-2;Q6NUK1 Q6YN16 J3KRP4;A0A0 87WVI0;E9PB L8;Q8WTW3 P ;P43686 E7EU85;E9P FF5;B4DXZ6; P ;P ;P51114 P ;P10599 H0YD14;Q9N ZM1-2;Q9NZM1-6;Q9NZM1-3;Q9NZM1 A0A096LP73; A0A096LP12; A0A096LNH5; H7C2G3;F2Z 2Q0;H7BYH1; A0A096LPI6; P30042 J3QL86;J3QS 62;J3QQY1;Q 96JB5-2;Q96JB5;Q9 6JB5-4 Methylated-DNA-- protein-cysteine methyltransferase Calcium-binding carrier protein SCaMC-1 Hydroxysteroid dehydrogenase-like protein 2 Conserved oligomeric Golgi complex subunit 1 26S protease regulatory subunit 6B Fragile X mental retardation syndromerelated protein 1 DML ratio AA- CW236/DMSO SEM MGMT 3.80E SLC25A E HSDL2 2.72E ADCK1;COG1 8.04E PSMC4 2.26E FXR1 5.17E Thioredoxin TXN 4.52E Myoferlin MYOF 2.34E ES1 protein homolog, CDK5 regulatory subunit-associated protein 3 C21orf E CDK5RAP3 2.04E AWQDAAACP R TCPFCSK CLSSLKDER CAVVDVPFG GAK FCAFVQEAES RPR GVLFYGPPG CGK Q86UR1-3;Q86UR1;Q8 6UR1-2 Q9H7Z7 Carbamidomet hyl (C);IAAyne P ;P52209;K7 ELN9 P ;P ;P49448;P M0QYS3;M0 QYC1;M0QZ R4;Q ;Q92888;Q ;Q P55072 NADPH activator 1 oxidase Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 6-phosphogluconate dehydrogenase, decarboxylating Glutamate dehydrogenase 1, ;Glutama te dehydrogenase 2, Rho nucleotide factor 1 guanine exchange Transitional endoplasmic reticulum NOXA1 3.72E PTGES2 4.79E PGD 6.61E GLUD1;GLUD E ARHGEF1 6.87E VCP 1.00E S156

157 ATPase IVGCSVHK G3V2H6;G3V 4M8;E5RG71; G3V5X6;G3V 3K6;G3V251; B4DSU6;G3V 555;G3V575; G3V576;G3V 4W0;B3KT61; B4DY08;B2R 5W2;G3V4C1 ;G3V2Q1;P ;Q86SE5;P ;Q86SE5-3;P07910 Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein HNRN;RAL YL 3.60E CMALSTAVLV GEAKK DSPQSLTDES CSEK KVIGIECSSIS DYAVK CEFQDAYVLL SEK VCVETVESGA MTK LPQKEPVGCS K KCPFYAAEQD KGALEGSSCP FR CVICDSYVRP CTLVR RGPEVTSQG VQTSSPACK Carbamidomet hyl (C);IAAyne 2 Carbamidomet hyl (C);IAAyne G3V4Z4;Q ;Q02252 Q9BV36-4;Q9BV36-2;Q9BV36 E9PIX6;E9PK G1;H7C2I1;Q ;Q ;Q ;Q99873;E9 PMW9;E9PI8 3;E9PNR9;E9 PQ98;H0YDE 4;A0A087X1 W2 P10809 P ;P48735 Q9P206;Q9P 206-3;Q9P206-2 A0A087WT44 ;P ;P30519 Q7RTV0 F8W0B5;F8W B05;H0YH87; F8WB06;F8V QP2;V9GY86; Q ;Q ;Q ;Q99700 Methylmalonatesemialdehyde dehydrogenase [acylating], ALDH6A1 1.15E Melanophilin MLPH 5.90E Protein arginine N- methyltransferase 1 60 kda heat shock protein, Isocitrate dehydrogenase [NADP], Uncharacterized protein KIAA1522 PRMT1 1.43E HSPD1 6.26E IDH2 2.21E KIAA E Heme oxygenase 2 HMOX2 0.00E PHD finger-like domain-containing protein 5A PHF5A 6.76E Ataxin-2 ATXN2 4.44E TYGCVPVANK R I3L0X5;O Sperm-associated antigen 7 SPAG7 2.62E CSFDVVKR LLTSQCGAAE EEFVQR Q9Y678 P82933 Coatomer gamma-1 subunit 28S ribosomal protein S9, COPG1 9.03E MRPS9 4.44E S157

158 CMALSTAVLV GEAK KCLEELQKR VVCSSGAVG NYSGGLAVK NCSSFLIK CESAFLSK VAIEPGAPRE NDEFCK CELFDQNLK CMALSTAVLV GEAK CPDYYENNV HK EMVECFNK LDADIHTNTC R IECEIKINHEG EVNR SLSCLSDLDG GVALEPR VICAEEPYICK LPPSGSKPVA ASTCSGKK Oxidation (M); G3V4Z4;Q ;Q02252 P49721;A0A0 87WVV1 P16455 H0YLP6;H0Y MF4;H0YKD8 ;P ;P ;P46779;P ;P C9JXB8;C9J NW5;P83731 H0YLA4;Q E9PKS9;E9P QE8;J3KP27; Q9Y296-2;Q9Y296 G3V4Z4;Q ;Q02252 Methylmalonatesemialdehyde dehydrogenase [acylating], Proteasome subunit beta type-2 Methylated-DNA-- protein-cysteine methyltransferase 60S ribosomal protein L28 60S ribosomal protein L24 Sorbitol dehydrogenase Trafficking particle subunit 4 Methylmalonatesemialdehyde dehydrogenase [acylating], protein complex ALDH6A1 5.09E PSMB2 1.63E MGMT 4.95E RPL E RPL E SORD 1.99E TRAP4 5.02E ALDH6A1 2.54E Q9H9F9 Actin-related protein 5 ACTR5 1.57E M0QYT0;M0R 280;M0QXS7; M0QZW4;M0 R248;Q13011 C9J8T0;P ;P57772 Q5JP01;E9P C52;Q16576; Q O95685 Selenocysteinespecific elongation factor Carbamidomet hyl (C);IAAyne P ;P49915 GMP synthase [glutaminehydrolyzing] O ;O ;O ;O43663;H3 BSJ8;H0YNE 4;G3V3N7 Delta(3,5)-Delta(2,4)- dienoyl-coa isomerase, Histone-binding protein RBBP7 Protein phosphatase 1 regulatory subunit 3D Protein regulator of cytokinesis 1 ECH1 1.47E EEFSEC 1.67E RBBP7 5.16E PPP1R3D 3.69E GMPS 4.40E PRC1 6.10E KACPLQPDHT NDEKE H0YKX3;Q NA-associated factor KIAA E AGSMSAELG VGCALR E5RFZ4;E5R G77;O94903 Proline synthase cotranscribed bacterial homolog protein PROSC 8.58E CEILQSDSR Q14145 Kelch-like ECHassociated protein 1 KEAP1 4.52E NIQACKELAQ TTR IDRYTQQGFG NLPICMAK Oxidation (M); P ;P50990;H7 C4C8 Q4VXM0;A0A 087WVM4;B7 ZM99;Q6UB3 5 T-complex protein 1 subunit theta Monofunctional C1- tetrahydrofolate synthase, CCT8 5.10E MTHFD1L 7.49E S158

159 IGNCPFSQR O00299 Chloride intracellular channel protein 1 CLIC1 1.37E CMPTFQFFK P ;P10599 Thioredoxin TXN 2.23E NLDSTTVAVH GEEIYCK FRKAQCPIVE R LGPSTGSTAE TQCR P21291;E9PS 42;E9PND2 M0R0F0;M0R 0R2;P46782 Q5T9K0;Q5T 200-2;Q5T200 Cysteine and glycinerich protein 1 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed Zinc finger CCCH domain-containing protein 13 CSRP1 2.13E RPS5 3.75E ZC3H E VRCWQYR E7ERA2;E7E X53;E7EQV9; E7ENU7;P ;P61313 Ribosomal L15;60S protein L15 protein ribosomal RPL E TQNLPNCQLI SR LGYILTCPSNL GTGLR ADEASELACP TPK CIPALDSLTPA NEDQK NVIETCK LYVYNTDTDN CR E9PNM1;P ;P ;P ;P ;P37268 P12532;P175 40;P P49327 P10809 C9JDR0;Q Q9H8Y8-2;Q9H8Y8;Q9 H8Y8-3 Squalene synthase FDFT1 1.89E Creatine kinase U- type, ;Creatine kinase S-type, Fatty acid synthase;[acyl-carrierprotein] S- acetyltransferase;[acyl -carrier-protein] S- malonyltransferase;3- oxoacyl-[acyl-carrierprotein] synthase;3- oxoacyl-[acyl-carrierprotein] reductase;3- hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl- [acyl-carrier-protein] hydrolase 60 kda heat shock protein, Sterol-4-alphacarboxylate 3- dehydrogenase, decarboxylating Golgi reassemblystacking protein 2 CKMT1A;CKM T2 1.72E FASN 2.17E HSPD1 7.43E NSDHL 3.21E GORASP2 6.52E CRDPPSNPVA ASPR SKGDCQTLSE GSPGSSQSG SR CGDLVFAK KPLMVIHHLE DCQYSQALK Oxidation (M); Q8ND82;Q9U JJ2 F8WEE6;O ;O94972 P51858 H7C040;B5M C62;Q8TD06 Zinc finger protein 280C E3 ubiquitin-protein ligase TRIM37 Hepatoma-derived growth factor Anterior gradient protein 3 homolog ZNF280C 9.32E TRIM E HDGF 3.70E AGR3 1.32E MVSTPIGGLS YVQGCTKK D6RF87;E9P F16;Q96CM8-3;Q96CM8;Q 96CM8-2 Acyl-CoA synthetase family member 2, ACSF2 3.87E S159

160 KGADIMYTGT VDCWRK SEGGFIWACK P12236;P O75874 ADP/ATP translocase 3;ADP/ATP translocase 3, N- terminally processed;adp/atp translocase 1 Isocitrate dehydrogenase [NADP] cytoplasmic SLC25A6;SLC 25A4 6.62E IDH1 3.99E SIKDTICNQDE R H0YHL7;B4E 3S0;Q9ULV4; Q9ULV4-2;Q9ULV4-3 Coronin;Coronin-1C CORO1C 1.25E VMSQNFTNC HTK DSAQCAAIAE R CDKVAQDLCK LNGGLGTSM GCK Oxidation (M); Carbamidomet hyl (C);IAAyne E5RI46;E5RI F8;E5RH42;E 5RIZ6;E5RJU 8;Q ;Q13283 Q96RS6-3;Q96RS6-2;Q96RS6 H0YKF0;H0Y LU7;P13804 C9JUW1;C9J WG0;C9JVG3 ;C9JQU9;C9J NZ1;A0A087 WYS1;E7EU C7;Q ;Q16851 Ras GTPaseactivating proteinbinding protein 1 NudC domaincontaining protein 1 Electron transfer flavoprotein subunit alpha, UTP--glucose-1- phosphate uridylyltransferase G3BP1 6.79E NUDCD1 4.22E ETFA 2.29E UGP2 3.14E TKSCSGVEFS TSGHAYTDTG K Q9Y277;E5R HE1;E5RJN6; E5RHZ6 Voltage-dependent anion-selective channel protein 3 VDAC3 5.77E EVCGFAPYER VQPQWSPPA GTQR DAGGKSWCP DCVQAEPVV R CLSVMEAK GCWDSIHVVE VQEK NPLNLQK IRPLNSEGTL NLLNCEPPR J3QSB5;Q9Y 3U8 C9JLN0;E9P RS8;E9PLP0; B4DKY1;P ;P49589;P I3L0K2;I3L3M 7;Q9BRA2 H3BPK7;P49 588;P B1AK87;B1A K85;B1AK88; P ;P47756 Q ;Q92754 Q9Y5S2 60S ribosomal protein L36 Cysteine--tRNA ligase, cytoplasmic Carbamidomet hyl (C);IAAyne Oxidation (M); Thioredoxin domaincontaining protein 17 Alanine--tRNA ligase, cytoplasmic F-actin-capping protein subunit beta Transcription factor AP-2 gamma Serine/threonineprotein kinase MRCK beta RPL E CARS 6.90E TXNDC E AARS 7.79E CAPZB 2.87E TFAP2C 1.54E CDC42BPB 2.88E VIVKCPTSGR E7EMB6;E7E TB3;Q9ULA0; C9JBE1;C9J RG3;C9J1E2; E7EPX3;B9Z VU2;F8WAN0 Aspartyl aminopeptidase DNPEP 1.29E ISLGLPVGAVI NCADNTGAK P62829;C9JD 32;B9ZVP7;J 3KT29 60S ribosomal protein L23 RPL E S160

161 KGTDIMYTGT LDCWRK DKMCSMVKK GCENLNIVQD K SKTSNKPLMII HHLDECPHS QALK DVCTFLR Oxidation (M); Oxidation (M); Oxidation (M); P05141 D6RB09;D6R G13;D6RAT0; P61247;D6RE D7;D6RAS7; H0Y8L7;E9PF I5 Q7Z417 C9J3E2;B5M C07;O95994 P08574 ADP/ATP translocase 2;ADP/ATP translocase 2, N- terminally processed 40S ribosomal protein S3a Nuclear fragile X mental retardationinteracting protein 2 Anterior gradient protein 2 homolog Cytochrome c1, heme protein, SLC25A5 1.15E RPS3A 1.42E NUFIP2 5.22E AGR2 5.31E CYC1 1.30E KVFANPEDCV AFGKGENAK F5H7F6;F5H6 X2;P ;P10620 Microsomal glutathione S- transferase 1 MGST1 7.57E GHSCYRPR P62753;A2A3 R5 40S ribosomal protein S6 RPS6 2.42E FCPFAER Q5TA01;Q5T A02;P ;P ;P78417 Glutathione S- transferase omega-1 GSTO1 1.81E YSSAFCNK GQKCEFQDA YVLLSEKK SKEIDKCLSR FRNTGQTCV CSNQFLVQR VYQHQVVAN CR D6RDV0;D6R A37;A0A0A0 MTC2;D6RIY 7;Q ;Q13454 P10809 Q14344 C9J8Q5;P516 49;P P ;P ;P34896 Tumor suppressor candidate 3 Carbamidomet hyl (C);IAAyne 60 kda heat shock protein, Guanine nucleotidebinding protein subunit alpha-13 Succinatesemialdehyde dehydrogenase, Serine hydroxymethyltransfer ase, cytosolic TUSC3 1.28E HSPD1 9.46E GNA E ALDH5A1 1.54E SHMT1 1.17E QGFGNLPICM AK F5H2F4;P115 86;V9GYY3 C-1-tetrahydrofolate synthase, cytoplasmic;methylene tetrahydrofolate dehydrogenase;methe nyltetrahydrofolate cyclohydrolase;formyl tetrahydrofolate synthetase;c-1- tetrahydrofolate synthase, cytoplasmic, N-terminally processed MTHFD1 6.61E LTSSCPDLPS QTDKK FSVCVLGDQ QHCDEAK LLVGNKCDLT TK Carbamidomet hyl (C);IAAyne P56962 Syntaxin-17 STX E P62906 E7END7;P ;P S ribosomal protein L10a Ras-related Rab-1A protein RPL10A 1.20E RAB1A 7.54E S161

162 ACSLAK AKADPDCSN GQPQAAPTP GAPQNRK SCSGVEFSTS GHAYTDTGK TYDPSGDSTL PTCSKK ACGSEIMQK LSEEAECPNP STPSK RISASCQHPT AFEEAIPK LQDLAAGPVG SLCR RQDSDLVQC GVTSPSSAEA TGK EACSYTIHAE GDER ICSHSAPEQQ AR GVLFGVPGAF TPGCSK AESSQTCHSE QGDKKMEEK QRPGSDECL R VFPPEIVEQM GCK ELEVLLMCNK ACAEVSQWT R ECFLIQPK LCYSSDHEK VDENFDCVEA DDVEGK AVEEDGHLKC PR YSNSDVIIYVG CGER ICPVETLVEEA IQCAEK SWCPDCVQA EPVVR Oxidation (M); E7EX29;P631 04;B7Z2E6;H 0YB80;B0AZ S6;P ;P ;P31946 Q9BW85 Q9Y277;E5R HE1;E5RJN6; E5RHZ protein zeta/delta; protein beta/alpha; protein beta/alpha, N-terminally processed Coiled-coil domaincontaining protein 94 Voltage-dependent anion-selective channel protein 3 YWHAZ;YWH AB 1.17E CCDC E VDAC3 7.58E Q9Y2X3 Nucleolar protein 58 NOP E P ;P15924 O94804 E7EMB6;E7E TB3;Q9ULA0; C9JBE1 Q69YL0 Q9HC52 H0YGC7;F5H 362;F5H755;F 5H5A1;Q4G1 76 Desmoplakin DSP 4.72E Serine/threonineprotein kinase 10 Aspartyl aminopeptidase Uncharacterized protein NCBP2-AS2 Chromobox homolog 8 protein Acyl-CoA synthetase family member 3, STK E DNPEP 5.13E NCBP2-AS2 2.01E CBX8 8.45E ACSF3 1.00E O75683 Surfeit locus protein 6 SURF6 2.17E P ;P ;P30044 P46063 Q9UM82 I3L0N3;P ;P46459 D3YTB1;F8W 727;P62910 D6RCC4;D6R CC9;Q8NEC7 C9J384;Q9B Q75-2;Q9BQ75 P21266;A0A0 A0MTN3 O14929;O Q9P275;Q9P P ;P38606 P30084 I3L0K2;I3L3M 7;Q9BRA2 Peroxiredoxin-5, ATP-dependent helicase Q1 DNA Spermatogenesisassociated protein 2 PRDX5 5.51E RECQL 0.00E SPATA2 5.36E Vesicle-fusing ATPase NSF 2.29E S ribosomal protein L32 Glutathione S- transferase C-terminal domain-containing protein RPL E GSTCD 2.47E Protein CMSS1 CMSS1 1.14E Glutathione S- transferase Mu 3 Histone acetyltransferase type B catalytic subunit Ubiquitin carboxylterminal hydrolase 36 V-type proton ATPase catalytic subunit A Enoyl-CoA hydratase, Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne Thioredoxin domaincontaining protein 17 GSTM3 3.24E HAT1 4.89E USP E ATP6V1A 2.32E ECHS1 1.66E TXNDC E S162

163 NRTQEQCVH NETKNELEK VIGIECSSISD YAVK SIQFVDWCPT GFK AKPTGSGKEE GPAK ESCGSSVLTD FEGKDVATK IDRYTQQGFG NLPICMAK LPEEEAECYF HSRPK YWCDAEYDA YRR DLSYCLSGMY DHR LLAPDCEIIQE VGK REEEEDDDC PVRK AVCLLTGASR Oxidation (M); E5KLK1;E5KL J6;E5KLJ9;E5 KLJ5;O60313; O E9PIX6;E9PK G1;H7C2I1;Q ;Q ;Q ;Q99873;E9 PMW9;E9PI8 3;E9PNR9;E9 PQ98;H0YDE 4;A0A087X1 W2 P ;P ;P68366;P D6RCB6;Q8I UF8-2;Q8IUF8-4;Q8IUF8 H0Y704;O ;O ;O ;O15231;O ;O ;O ;O ;O ;H7BZT5 P52597 Q9NQT5 Q8IWD4 Dynamin-like 120 kda protein, ;Dynami n-like 120 kda protein, form S1 Protein arginine N- methyltransferase 1 Tubulin alpha-1b chain;tubulin alpha-4a chain Bifunctional lysinespecific demethylase and histidylhydroxylase MINA OPA1 1.83E PRMT1 1.93E TUBA1B;TUB A4A 1.01E MINA 4.21E Zinc finger protein 185 ZNF E Monofunctional C1- tetrahydrofolate synthase, Q4VXM0;A0A 087WVM4;B7 ZM99;Q6UB3 5 J3QQV6;Q9N VS9-2;Q9NVS9-3;Q9NVS9 X6RGP5;F1T 0I1;J3KNL6;O ;O ;O ;O15027;O Pyridoxine-5'- phosphate oxidase Protein transport protein Sec16A Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N- terminally processed Exosome complex component RRP40 Coiled-coil domaincontaining protein 117 MTHFD1L 1.07E PNPO 5.60E SEC16A 4.86E HNRNPF 3.74E EXOSC3 1.18E CCDC E P35270 Sepiapterin reductase SPR 6.01E S163

164 GLGTDEDSLI EIICSR P07355;A6N MY6;P ;H0YLE2;H0 YN52;H0YNA 0;H0YN28;H0 YL33;H0YMM 1;H0YNP5;H0 YKS4;H0YMD 0;H0YMU9;H 0YM50;H0YN 42 Annexin A2;Putative annexin A2-like protein;annexin ANXA2;ANXA 2P2 3.76E LDVGNFSWG SECCTRK GVLMYGPPG CGK TSAVPSGK RPGCFLCR TGSQGQCTQ VRVEFMDDT SR ADTLTPEECQ QFKK P62241 Carbamidomet hyl (C);IAAyne P ;P43686 P ;P49748;P Carbamidomet hyl (C);IAAyne Q9BRX8-2;Q9BRX8 P62857 H0Y3Y4;G3V 1Q4;E7ES33; E7EPK1;Q ;Q S ribosomal protein S8 26S protease regulatory subunit 6B Very long-chain specific acyl-coa dehydrogenase, Redox-regulatory protein FAM213A 40S ribosomal protein S28 RPS8 3.96E PSMC4 1.86E ACADVL 1.43E FAM213A 1.07E RPS E Septin-7 SEPT7 7.08E GASCPDFR Q17RN3;K7E QL1;K7EQT7; Q17RN3-2 Protein FAM98C FAM98C 8.92E VCTLAIIDPGD SDIIR E5RI99;P S ribosomal protein L30 RPL E TTSSANNPNL MYQDECDRR H3BLZ8;Q ;Q ;Q ;Q92841 ATP- RNA Probable dependent helicase DDX17 DDX E EGRLEDVENL GCR Q9UJX3-2;Q9UJX3 Anaphase-promoting complex subunit 7 ANA7 3.57E SQTTYYAQCY R B7ZC39;B7Z C38;Q9NR46; Q9NR46-2 Endophilin-B2 SH3GLB2 4.65E KFMADCPHTI GVEFGTR LQGSCTSCPS SIITLK YQIDPDACFS AK Carbamidomet hyl (C);IAAyne X6RFL8;P C9J8Q1;F8W 9P7;H7C537; Q9UMS0-2;Q9UMS0-3;Q9UMS0 P21796 Ras-related Rab-14 protein NFU1 iron-sulfur cluster scaffold homolog, Voltage-dependent anion-selective channel protein 1 RAB E NFU1 2.36E VDAC1 8.93E QGFGNLPICM AK Oxidation (M); F5H2F4;P115 86;V9GYY3 C-1-tetrahydrofolate synthase, cytoplasmic;methylene tetrahydrofolate dehydrogenase;methe nyltetrahydrofolate cyclohydrolase;formyl tetrahydrofolate synthetase;c-1- tetrahydrofolate synthase, cytoplasmic, N-terminally processed MTHFD1 4.29E S164

165 CGEPSRPAA CR AANGLEADNS CPNSK VVNEINIEDLC LTK GGGGYTCQS GSGWDEFTK Q9H8P0;H0Y 9P9 Carbamidomet hyl (C);IAAyne Q86V48-2;Q86V48-3;Q86V48 D6RCF4;Q8N 5K1 P ;P15924;P Polyprenol reductase SRD5A3 5.38E Leucine zipper protein 1 CDGSH iron-sulfur domain-containing protein 2 LUZP1 6.79E CISD2 1.16E Desmoplakin DSP 5.72E NTYVCSER H0YKP9;A2S Y06;H0YIY6; A0A0A0MST9 ;A0A0A0MQR 8;A0A0A0MS Z1;A0A0A0M T23;J3KNR0; P ;P ;P ;P ;P ;P27448;P MAP/microtubule affinity-regulating kinase 3 MARK3 7.73E FMADCPHTIG VEFGTR X6RFL8;P Ras-related Rab-14 protein RAB E GPAPAPQQC SEPETK ECLAETER CSLPAEEDSV LEK AVLCPPPVK B1AMX5;G3V 154;Q3YEC7; Q3YEC7-2 O ;O14519;O E7EVA0;P ;P27816 P63000;P607 63;P Rab-like protein 6 RABL6 1.87E Cyclin-dependent kinase 2-associated protein 1;Cyclindependent kinase 2- associated protein 2 Microtubuleassociated protein;microtubuleassociated protein 4 Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 3 CDK2AP1;CD K2AP2 3.48E MAP4 1.42E RAC1;RAC3 5.47E CPTSGRLEQ QLVHVERPIL R E7EMB6;E7E TB3;Q9ULA0; C9JBE1;C9J RG3;C9J1E2; E7EPX3;B9Z VU2;F8WAN0 Aspartyl aminopeptidase DNPEP 1.04E CGAETQHEG LELR ALDLDSSCKE AADGYQR FITVCDYTNP CTK Carbamidomet hyl (C);IAAyne B5MC98;Q9H CU5 H0YGI8;P ;P31948;P A0A0A0MSI9; A0A0A0MS70 ;H0Y4G9;A0A 0A0MST0;Q ;Q ;Q99836;Q Prolactin regulatory element-binding protein Stress-inducedphosphoprotein 1 Myeloid differentiation primary response protein MyD88 PREB 3.68E STIP1 1.34E MYD E AAVEEGIVLG GGCALLR P kda heat shock protein, HSPD1 1.27E S165

166 KFMADCPHTI GVEFGTR AAREECPVFT PPGGETLDQ VK KCPQEAGAS DQPEPTR MMIPDCQR QPSESDIIT EEDKSK Oxidation (M); X6RFL8;P Q9NQ88 P24588 E5RIW3;E5R JD8;E5RHG6; O75347;O O ;O ;O75475 Ras-related Rab-14 protein Fructose-2,6- bisphosphatase TIGAR A-kinase anchor protein 5 Tubulin-specific chaperone A 4 and SFRS1- interacting protein RAB E TIGAR 1.36E AKAP5 2.25E TBCA 5.88E PSIP1 9.41E ITNSLTVLCSE K H0YGJ7;H0Y LP3;O ;O ;O75822 Eukaryotic translation initiation factor 3 subunit J EIF3J 4.36E EDFCPR Q9H0W8-2;Q9H0W8 Protein SMG9 SMG9 5.58E ETIGVGSYSE CKR E9PRI4;E9PG T3;Q ;Q15418;Q Ribosomal protein S6 kinase;ribosomal protein S6 kinase alpha-1 RPS6KA1 8.07E VSSSCLDLPD STEEK Q5VT52-2;Q5VT52-3;Q5VT52 Regulation of nuclear pre-mrna domaincontaining protein 2 RPRD2 1.33E LSALCPK Q14149 MORC family CW-type zinc finger protein 3 MORC3 2.00E AGSDGESIGN CPFSQR Q9Y696 Chloride intracellular channel protein 4 CLIC4 0.00E EAPSPTCPDL GAK FLTFKDCDPG EVNK QGECLNFGIK TIQFVDWCPT GFK O00257 Q9NYK5;C9J G87;Q9NYK5-2 E9PQ61;O75 152;E9PBY7 F5H5D3;Q9B QE3 E3 SUMO-protein ligase CBX4 39S ribosomal protein L39, Zinc finger CCCH domain-containing protein 11A CBX4 3.29E MRPL E ZC3H11A 1.66E Tubulin alpha-1c chain TUBA1C 2.35E QQCEFAK F6SKB8;D6R B24;Q9NVZ3-3;Q9NVZ3-4;Q9NVZ3;Q9 NVZ3-2 Adaptin ear-binding coat-associated protein 2 NECAP2 1.30E IKSGEEDFES LASQFSDCSS AK FMADCPHTIG VEFGTR CLLIHPNPES ALNEEAGR Oxidation (M); K7EN45;K7E MU7;Q13526 X6RFL8;P K7EPJ1;Q Peptidyl-prolyl cistrans isomerase NIMAinteracting 1 Ras-related Rab-14 protein Ubiquitin-conjugating enzyme E2 S PIN1 4.98E RAB E UBE2S 8.44E YSNSALGHVN CTIK H7C106;F8W 914;Q9NQC3-3;Q9NQC3-2;Q9NQC3-5;Q9NQC3-4;Q9NQC3-6;Q9NQC3 Reticulon;Reticulon-4 RTN4 4.06E GFNKETAAAC VEK E9PGT1;Q Translin TSN 5.78E S166

167 CPASEPGLDA TTASESR SEETNTEIVE CILK NCSSPEFSK VAYDK SACGVCPGR NLETFCEETR R VGVGTCGIAD KPMTQYQDT SKYNVR MVSTPIGGLS YVQGCTK A0A0A0MQU 1;Q27J81-2;Q27J81 A0A087WV66 ;P46013;P Q5JX53;Q5JX 54;Q5JX57;E 7EV27;Q5JX5 5;Q5JX56;Q5 JX58;Q5JX59 ;Q5JX61;Q5J X60;Q5JX44; Q5JX52;Q5JX 45;E7ENH5;A 6PVH9;F2Z2 V0;B0QZ18;Q Inverted formin-2 INF2 1.19E Antigen KI-67 MKI E Copine-1 CPNE1 6.36E P46109 Crk-like protein CRKL 3.20E P49207 Carbamidomet hyl (C);IAAyne Q9P2J5-2;Q9P2J5 O75940 D6RF87;E9P F16;Q96CM8-3;Q96CM8;Q 96CM8-2 60S ribosomal protein L34 Leucine--tRNA ligase, cytoplasmic Survival of motor neuron-relatedsplicing factor 30 Acyl-CoA synthetase family member 2, RPL E LARS 1.11E SMNDC1 2.37E ACSF2 5.27E IAAESSENVD CPENPK Q32MZ4-3;Q32MZ4-2;Q32MZ4 Leucine-rich repeat flightless-interacting protein 1 LRRFIP1 1.81E NVVACESIGR Q9H0U6 39S ribosomal protein L18, MRPL E KLLDLVQQSC NYK SYESSEDCSE AAGSPARK LCYVGYNIEQ EQK B1AHD1;P K7ER58;Q6P 6C2-3;Q6P6C2 F5H6T1;P611 60;P NHP2-like protein 1;NHP2-like protein 1, N-terminally processed RNA demethylase ALKBH5 NHP2L1 3.05E ALKBH5 4.44E Actin-related protein 2 ACTR2 1.53E FQEHCPDLER QEAEVHK RAPDGTDPP PPHTSDTQAC SR APIEVVK GCNPSGHTQ SVTTPEPAKE GTK GLATFCLDK K7EKI8;O604 37;K7EQ71 H7C1N2;J3K R05;O ;O ;O75128;O ;O Q68CP9-3;Q68CP9;F8 W108;F8WC U9 H7C1E7;A0A 0A0MRP7;H0 Y542;G3XAF 7;O75363;O U3KQM0;O00 264;O15173; O Periplakin PPL 4.53E Protein cordon-bleu COBL 9.83E AT-rich interactive domain-containing protein 2 Breast carcinomaamplified sequence 1 Membrane-associated progesterone receptor component 1;Membraneassociated progesterone receptor ARID2 4.36E BCAS1 1.12E PGRMC2;PG RMC1 6.75E S167

168 component 2 QMEKDETVS DCSPHIANIG R IEEACEIYAR AGLHCTQAYP VR B1AK87;B1A K85;B1AK88; P ;P47756 M0R0Y2;M0R 2M1;P54920 Q92585 F-actin-capping protein subunit beta Alpha-soluble NSF attachment protein Mastermind-like protein 1 CAPZB 9.19E NAPA 1.35E MAML1 2.31E ELAQQVQQV ADDYGKCSR H3BLZ8;Q ;Q ;Q ;Q92841 ATP- RNA Probable dependent helicase DDX17 DDX E CYYSNTDAVI YVVDSCDRD R Carbamidomet hyl (C);IAAyne B4DZG7;F8V YN9;P ;P40616 ADP-ribosylation factor-like protein 1 ARL1 1.13E ALVQVLR Q5THU2;Q5T 2H3;Q9NVV5-6;Q9NVV5-5;Q9NVV5-3;Q9NVV5-2;Q9NVV5 Androgen-induced gene 1 protein AIG1 2.77E GNSPPSSGE ACREEK P ;P41227 N-alphaacetyltransferase 10 NAA E QYPWGVVQV ENENHCDFV K E7EW69;E7E X04;B5ME97; Q9P0V9;Q9P 0V9-2;D6RDU5;D6 RGI3;A0A087 X142;A6NMH 6;D6RER5;A6 NFQ9;F8W8I 8;Q ;Q9NVA2;Q ;Q9P0V9-3;Q9NVA2-2;Q ;Q92599 Septin-10;Septin- 8;Septin-11 SEPT10;SEPT 11;SEPT8 7.70E VCENIPIVLCG NK DLNYCFSGM SDHR YVAAAFPSAC GK Carbamidomet hyl (C);IAAyne Oxidation (M); B4DV51;F5H 018;B5MDF5; J3KQE5;P E9Y7;G8J LB6;P31943; H0YBG7;H0Y BD7;H0YB39; P55795 A0A0A0MS74 ;H0YML5;B4D W73;H0YM31 ;Q ;Q16822 GTP-binding protein Ran nuclear Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N- terminally processed;heterogene ous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed Phosphoenolpyruvate carboxykinase [GTP], RAN 4.49E HNRNPH1;HN RNPH2 1.24E K2 1.09E S168

169 TKSCSGVEFS TSGSSNTDTG K A2A3S1;Q5J SD2;Q5JSD1; A0A0A0MR02 ;P ;P45880;P Voltage-dependent anion-selective channel protein 2 VDAC2 7.30E REEGDPSPH SGGVCKPK O ;O75376;J3K RE4;E7EVK1 Nuclear receptor corepressor 1 NCOR1 1.03E GNMNCGAFQ AHQMR LTALDYHNPA GFNCKDETEF R CEFQDAYVLL SEKK H0Y612;E7E N20;Q9UPN9-2;Q9UPN9 G3V4E7;G3V 4C6;Q9Y224 P10809 E3 ubiquitin-protein ligase TRIM33 UPF0568 C14orf166 protein 60 kda heat shock protein, TRIM E C14orf E HSPD1 2.80E VCNFLASQVP FPSR EVLCPESQSP NGVR LKPDPEPDDK NQEPSSCK Q ;Q99714 Q ;Q14684 H3BNK9;H3B U93;Q9GZU8 3-hydroxyacyl-CoA dehydrogenase type-2 Ribosomal RNA processing protein 1 homolog B HSD17B E RRP1B 8.18E Protein FAM192A FAM192A 7.66E CQPKPSEEAP K Q9H6F5 Coiled-coil domaincontaining protein 86 CCDC E GIGMNEPLVD CEGYPR F5H7X1;F5H5 V4;F5GX23;J 3KN29;O ;O S proteasome non- ATPase regulatory subunit 9 PSMD9 4.91E NQSFCPTVNL DK GVPGAIVNVS SQCSQR CSWLVPSPK E9PJD9;P467 76;E9PLL6 J3QS45;J3KR Z4;J3KSZ5;J3 QL34;J3KS22 ;J3QS36;Q7Z 4W1 Q3SXM5-2;Q3SXM5 60S ribosomal protein L27a RPL27A 1.69E L-xylulose reductase DCXR 0.00E Inactive hydroxysteroid dehydrogenase-like protein 1 HSDL1 3.89E DSVTCSPGM VR Q96KC8 DnaJ homolog subfamily C member 1 DNAJC1 9.36E LNISFPATGC QK P62753;A2A3 R7 40S ribosomal protein S6 RPS6 3.08E EPSQVIFCNR P ;P ;P40337 Von Hippel-Lindau disease tumor suppressor VHL 9.44E LTVVDTPGYG DAINCR C9IY94;C9IZ U3;C9JQJ4;C 9J938;H7C31 0;C9JB25;C9 J2Q4;B5MCX 3;Q15019;Q ;Q ;B5MD47 Septin-2 SEPT2 2.51E EIQLAESR H3BP71;O ;O75150;A0 A087WTK2 E3 ubiquitin-protein ligase BRE1B RNF E QFLDFGSVNA CEK F8WEJ6;C9IY B4;Q15118;Q [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, PDK1 5.20E S169

170 VACSNWK AAAGEFADDP CSSVKR ALNALCDGLI DELNQALK GGGGGGF QPASR KCSTPEEIKK AVLLVGLCDS GK CLEEQGLK Q8NCH0 G3XAM7;P35 221;P ;E5RHV7;E5 RGY6;E5RG0 3;E5RJ41;E5 RIB1 P30084 Q96QR8 Enoyl-CoA hydratase, Transcriptional activator protein Purbeta P ;P60981;F6 RFD5 Q9Y5M8;C9J 5Z8 P ;P17812 Carbohydrate sulfotransferase 14 CHST E Catenin alpha-1 CTNNA1 3.35E ECHS1 1.15E PURB 3.67E Destrin DSTN 1.06E Signal recognition particle receptor subunit beta SRPRB 3.23E CTP synthase 1 CTPS1 2.17E IGKPHTVK H0YEN5;P15 880;I3L404;E 9PM36;E9PM M9;E9PPT0 40S ribosomal protein S2 RPS2 6.05E EIVHLQAGQC GNQIGAK SCEGQNPELL PK P04350;P683 71;M0R0X0;M 0R2T4;M0QY 85;M0QY37; M0QX14;M0R 042;M0R2D3; M0QYM7;M0 QZL7;M0R27 8 Q9NQW6-2;Q9NQW6 Tubulin beta-4a chain;tubulin beta-4b chain Actin-binding anillin protein TUBB4A;TUB B4B 1.40E ANLN 7.14E TQVCGILR P11413;P ;P ;E9PD92;E7 EM57;E7EUI8 Glucose-6-phosphate 1-dehydrogenase G6PD 3.35E CTVVSETISS K AATGEEVSAE DLGGADLHC RK Q68D10-2;Q68D10 D6RD67;D6R 9R1;D6RDF7; Q9HCC0-2;Q9HCC0 Protein SPT2 homolog SPTY2D1 1.82E Methylcrotonoyl-CoA carboxylase beta chain, MCCC2 7.26E EETQEDKDC PIKEEK B4DSN5;P Tyrosine-protein phosphatase nonreceptor type;tyrosineprotein phosphatase non-receptor type 1 PTPN1 7.61E AVQDLCGWR Q9P258 Protein RCC2 RCC2 9.90E ELPPDQAEYC IAR H9KV75;O ;P ;P12814;O4 3707;P ;P ;H0YJW3;H7 C144;F5GXS 2;O Alpha-actinin-4;Alphaactinin-1 ACTN1;ACTN E KAAAPAPEEE MDECEQALA AEPK SFAFLHCK P26641;P A0A0A0MSV0 ;O ;O00267 Elongation factor 1- gamma Transcription elongation factor SPT5 EEF1G 2.73E SUPT5H 9.52E S170

171 CGSSEDLHD VR APPPTPAPSG CDPR Q7Z4V5-2;Q7Z4V5-4 O95685 Hepatoma-derived growth factor-related protein 2 Protein phosphatase 1 regulatory subunit 3D HDGFRP2 2.34E PPP1R3D 2.57E GIGMNEPLVD CEGYPR Oxidation (M); F5H7X1;F5H5 V4;F5GX23;J 3KN29;O ;O S proteasome non- ATPase regulatory subunit 9 PSMD9 4.48E ATQCVPKEEI KDDNPHLK Q9HAV7 GrpE protein homolog 1, GRPEL1 4.37E GYDSAGVGF DGGNDKDWE ANACK Q ;Q06210 Glutamine--fructose-6- phosphate aminotransferase [isomerizing] 1 GFPT1 2.00E NGQVCFSTQ DHKNPR Carbamidomet hyl (C);IAAyne B8ZZF0;C9JI R6;O ;O ;O ;O75688 Protein 1B phosphatase PPM1B 6.58E RPGCFLCREE AADLSSLK VVVVSHDENL CR ICLQPPPTSR Carbamidomet hyl (C);IAAyne Q9BRX8-2;Q9BRX8 Q7L5L3-1;Q7L5L3 A2ABF4;P Redox-regulatory protein FAM213A Glycerophosphodieste r phosphodiesterase domain-containing protein 3 FAM213A 2.26E GDPD3 0.00E Valine--tRNA ligase VARS 1.40E EMIQKECAAI R O43747;O ;H3BN75;H3 BS13;H3BV3 0;H3BRM7;H 3BN71;B4DG E1;H3BR36;H 3BUN9;H3BN R4 AP-1 complex subunit gamma-1 AP1G1 1.05E AEAAALSTQC R VPTANVSVVD LTCR IVLTNPVCTEV GEK CAGNEDIITLR AEENKKEPLC R Q9H6T0-2;Q9H6T0 E7EUT5;P ;P04406 P41091;Q2VI R3 P12004 H3BUM8;H3B RL3;O14562 Epithelial splicing regulatory protein 2 Glyceraldehyde-3- phosphate dehydrogenase Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein Proliferating cell nuclear antigen Ubiquitin domaincontaining protein UBFD1 ESRP2 8.37E GAPDH 6.80E EIF2S3;EIF2S 3L 1.16E NA 9.09E UBFD1 2.84E SQCALEEYVR P24468;F1DA L9;P ;P ;P10589 COUP transcription factor 2;COUP transcription factor 1 NR2F2;NR2F1 5.85E KADVIVLAGT VCDFR KLPEEEAECY FHSRPK M0R026;A1L0 T0;M0QZX5 J3QQV6;Q9N VS9-2;Q9NVS9-3;Q9NVS9 Acetolactate synthaselike protein Pyridoxine-5'- phosphate oxidase ILVBL 1.26E PNPO 2.72E S171

172 QWNNCAFLE SSAK F5H823;B7ZB 78;F5GZG1;E 7ESV4;F5H7 Y6;P ;P ;P ;P61224;A6 NIZ1 Ras-related protein Rap-1b;Ras-related protein Rap-1b-like protein RAP1B 6.49E CSTPEEIKK P ;P60981;F6 RFD5 Destrin DSTN 2.86E LAVSSAC KSPSSDSWT CADTSTERR VNQIGSVTES LQACK Q15437;Q5Q PE1 H0YIQ0;E5R HH7;F8VWH9 ;Q8N6T3-4;Q8N6T3-5;Q8N6T3;Q8 N6T3-2 P ;P06733 Protein transport protein Sec23B ADP-ribosylation factor GTPase-activating protein 1 SEC23B 9.64E ARFGAP1 2.20E Alpha-enolase ENO1 0.00E GCTATLGNFA K H0YEN5;P15 880;E9PQD7 40S ribosomal protein S2 RPS2 7.83E ANCIDSTASA EAVFASEVKK M0QXL5;M0R 2Q4;P22087; M0R299 rrna 2'-Omethyltransferase fibrillarin FBL 1.20E TSSDPTCVEK EK C9J673;C9JK M9;O14980 Exportin-1 XPO1 4.49E IENLELMSQH GCNAWK QLAQKYNCD K DIKWDFTK O75934 M0R1M6;M0 R2S1;P62987 P ;P38606;C9J A17;C9JVW8 Pre-mRNA-splicing factor SPF27 Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40 V-type proton ATPase catalytic subunit A BCAS2 4.79E UBA E ATP6V1A 9.80E SKGFGFVCFS SPEEATK A0A087WTT1 ;E7EQV3;P ;P11940;H0 YB86;H0YEU 6;H0YAR2;H0 Y5F5;E7ERJ7 ;B1ANR0;Q9 H361;Q ;Q13310;Q Polyadenylate-binding protein 1;Polyadenylatebinding protein 3;Polyadenylatebinding protein 4 PAB1;PAB 4;PAB3 9.86E LLDLVQQSCN YK B1AHD1;P NHP2-like protein 1;NHP2-like protein 1, N-terminally processed NHP2L1 1.34E CDSADLRHDI DRR E9PK09;E9P QN2;E9PKI6; E9PK91;Q9N YF8-4;Q9NYF8-3;Q9NYF8-2;Q9NYF8 Bcl-2-associated transcription factor 1 BCLAF1 5.83E NLSTFAVDGK DCKVNK A0A096LP73; A0A096LP12; A0A096LNH5; H7C2G3;F2Z 2Q0;H7BYH1; A0A096LPI6; P30042 ES1 protein homolog, C21orf E S172

173 RYYEKR P S ribosomal protein S21, MRPS E VTDDLVCLVY KTDQAQDVK P49458 Signal recognition particle 9 kda protein SRP9 6.73E ENSQLDTSPP CLGGNKK Q9Y3E2 BolA-like protein 1 BOLA1 1.12E SILSPGGSCG PIKVK P ;P ;P ;P ;P78347 General factor II-I transcription GTF2I 1.05E ASSVTTFTGE PNTCPR P52943;H0YF A4;P Cysteine-rich protein 2 CRIP2 1.66E TIIPLISQCTPK G3XAL0;P ;P40926 Malate dehydrogenase;malat e dehydrogenase, MDH2 7.56E GQKCEFQDA YVLLSEK VRNCSSPEFS K TIAECLADELI NAAK CSSLYEER GTPEQPQCG FSNAVVQILR VCVETVESGA MTK LECVEPNCR Oxidation (M); Carbamidomet hyl (C);IAAyne P10809 Q5JX53;Q5JX 54;Q5JX57;E 7EV27;Q5JX5 5;Q5JX56;Q5 JX58;Q5JX59 ;Q5JX61;Q5J X60;Q5JX44; Q5JX52;Q5JX 45;E7ENH5;A 6PVH9;F2Z2 V0;B0QZ18;Q M0R0F0;M0R 0R2;P46782; M0QZN2 Q9Y4D7-2;Q9Y4D7 Q86SX6 P ;P48735 H0Y5B4;H7B Z11;J3KQN4; Q969Q0;P kda heat shock protein, HSPD1 4.81E Copine-1 CPNE1 1.36E S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed RPS5 3.10E Plexin-D1 PLXND1 7.26E Glutaredoxin-related protein 5, Isocitrate dehydrogenase [NADP], 60S ribosomal protein L36a-like;60S ribosomal protein L36a GLRX5 2.09E IDH2 1.34E RPL36A;RPL3 6A- HNRNPH2;RP L36AL 1.22E QLCDNAGFD ATNILNK Q ;Q ;Q ;Q99832 T-complex protein 1 subunit eta CCT7 2.94E ADLLLESH YR M0QY43;Q7Z 406-5;Q7Z406-4;Q7Z406;Q7 Z406-6;Q7Z406-2 Myosin-14 MYH E VCLLGDTGVG K J3QR51;Q136 36;Q9UL26 Ras-related protein Rab-31;Ras-related protein Rab-22A RAB31;RAB22 A 1.77E CGFLPGNEK H0YKU2;H0Y M70;A0A087 X1Z3;Q9UL46 Proteasome activator complex subunit 2 PSME2 3.19E ADTSLNNCEG AAGSTSEK Q5QPB1;O AN1-type zinc finger protein 5 ZFAND5 1.68E S173

174 SAFLCGVMK F6UXX1;O ;O ;O ;O ;O60506;O4 3390;O Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R SYNCRIP;HN RNPR 1.92E LLPDDPYEKA CQK Q5TA01;Q5T A02;P ;P ;P78417 Glutathione S- transferase omega-1 GSTO1 4.18E YMLDCR QLLEMAC NEK ISASCQHPTA FEEAIPK Carbamidomet hyl (C);Oxidation (M); Q9Y277;Q9Y Q5TBR0;Q9N R45 E7EMB6;E7E TB3;Q9ULA0; C9JBE1 Voltage-dependent anion-selective channel protein 3 VDAC3 4.34E Sialic acid synthase NANS 5.48E Aspartyl aminopeptidase DNPEP 7.17E SLLNQCIEER Q96GM8 Target of EGR1 protein 1 TOE1 4.23E AVCMLSNTTA IAEAWAR Oxidation (M); P ;P ;P68366;P Tubulin alpha-1b chain;tubulin alpha-4a chain TUBA1B;TUB A4A 1.52E GNGIVECLGP K SCFPASLTAS R ARGGCPGGE ATLSQPPPRG GTR VDASACGME R M0QZS6;Q9U BE0 Q7L2J0;Q7L2 J0-2 P20290 O ;O95671;O SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N- terminally processed 7SK snrna methylphosphate capping enzyme Transcription BTF3 factor N-acetylserotonin O- methyltransferase-like protein SAE1 3.62E MEE 1.34E BTF3 5.47E ASMTL 1.48E TVFAEHISDE CK QMEKDETVS DCSPHIANIG R ETAAACVEK CLEPSGNGG EGTR TSNKPLMIIHH LDECPHSQAL K VGLSGAPADA CSTAQK LRSDCESQE CVTK QNSVQEQPG TACLSK Oxidation (M); G5E9G0;P39 023;B5MCW2 ;H7C422;F8W CR1;H7C3M2 B1AK87;B1A K85;B1AK88; P ;P47756 E9PGT1;Q F8VS53;F8V U91;F8VRV3; O14508 C9J3E2;B5M C07;O95994 Q8NFW8 60S ribosomal protein L3 F-actin-capping protein subunit beta RPL3 1.49E CAPZB 1.96E Translin TSN 8.69E Suppressor of cytokine signaling 2 Anterior gradient protein 2 homolog N-acylneuraminate cytidylyltransferase SOCS2 7.21E AGR2 9.00E CMAS 3.27E Q9NS86 LanC-like protein 2 LANCL2 6.63E Oxidation (M); Carbamidomet hyl (C);IAAyne Q9NQW6-2;Q9NQW6 Actin-binding anillin protein ANLN 3.37E S174

175 VRCGLEHER Q9Y3X0 Coiled-coil domaincontaining protein 9 CCDC9 7.04E LINDCHGSVS EASSEQK P50851;E9PE M5;P Lipopolysaccharideresponsive and beigelike anchor protein LRBA 5.33E VFANPEDCVA FGKGENAKK F5H7F6;F5H6 X2;P ;P10620 Microsomal glutathione S- transferase 1 MGST1 4.30E MVSTPIGGLS YVQGCTKK Oxidation (M); D6RF87;E9P F16;Q96CM8-3;Q96CM8;Q 96CM8-2 Acyl-CoA synthetase family member 2, ACSF2 4.04E VCEEIAIIPSK K H0YN73;H0Y N88;A0A075B 716;P0CW22; P S ribosomal protein S17-like;40S ribosomal protein S17 RPS17;RPS17 L 2.88E SSGGFVWAC K P ;P48735;H0 YL11 Isocitrate dehydrogenase [NADP], IDH2 8.70E ACPRPEGLNF QDLK Q5TEJ0;P159 27;P ;P Replication protein A 32 kda subunit RPA2 9.72E ACPLQPDHTN DEKE YADLTEDQLP SCESLKDTIA R H0YKX3;Q P18669 NA-associated factor Phosphoglycerate mutase 1 KIAA E PGAM1 8.61E VLQCHKPVHA EYLEK F8VRL4;F8V RR0;Q9NZJ9-3;Q96G61;Q8 NFP7;Q9NZJ 9;Q9NZJ9-2 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3- beta;diphosphoinositol polyphosphate phosphohydrolase 3- alpha NUDT4;NUDT 11;NUDT E AVFPEGEE PLQLRK F5GWN4;F8 WBT0;A0A0A 0MSJ2;E7EU 13;Q96P48-5;Q96P48-7;Q96P48-2;Q96P48-4;Q96P48-1;Q96P48-3;Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domaincontaining protein 1 ARAP1 3.32E ASVGFGGSC FQK EPYKNQPEKT CVR GLDYEGGGC R O ;O60701;O J3QR07;Q96 MU7-2;Q96MU7 H7C2S8;O UDP-glucose 6- dehydrogenase YTH domaincontaining protein 1 Procollagen-lysine,2- oxoglutarate 5- dioxygenase 3 UGDH 4.03E YTHDC1 5.07E PLOD3 1.44E ASEDGESVG HCPSCQR 2 O95833 Chloride intracellular channel protein 3 CLIC3 1.12E EMFPYEASTP TGISASCR H0YJH7;G5E 972;P ;P42167 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopo ietin;thymopentin TMPO 3.67E YIELFLNSCPK H0Y8R1;F5H 5I6;H0YAK1; Q ;Q12849 G-rich sequence factor 1 GRSF1 4.92E S175

176 YGQNCHKGP PHSK O15355 Protein 1G phosphatase PPM1G 3.65E CFPAECRLR Q1L5Z9 LON peptidase N- terminal domain and RING finger protein 2 LONRF2 8.88E TAGQTGMCG GVR LTDCVVMRDP ASKR LLDAQLATGG LVCPAR Q5VTL8-2;Q5VTL8 A0A087WUI2; P ;P22626 A0A075B730; A0A087X1U6; P58107 Pre-mRNA-splicing factor 38B Heterogeneous nuclear ribonucleoproteins A2/B1 PRPF38B 1.85E HNRNPA2B1 5.94E Epiplakin EPPK1 1.03E RRLDECEEAF QGTK K7EMD0;K7E PX6;K7EKR3; K7ENH2;B3K Q25;K7ESG5; K9J957;P612 89;P ;P Proteasome activator complex subunit 3 PSME3 2.43E REDFCPR NCLNPQFSK AAAGEFADDP CSSVK Q9H0W8-2;Q9H0W8 E5RFT7;A0A 087WUS8;A0 A087WXR6;E 5RHZ0;A0A0 87WYQ3;O G3XAM7;P35 221;P ;E5RHV7;E5 RGY6;E5RG0 3;E5RJ41;E5 RIB1 Protein SMG9 SMG9 1.23E Copine-3 CPNE3 1.37E Catenin alpha-1 CTNNA1 6.75E NQCLFTNTQC K Carbamidomet hyl (C);IAAyne B7Z6B6;B7Z6 Q2;D6RJ07;Q 9UL40-3;Q9UL40;Q9 UL40-2 Zinc finger protein 346 ZNF E TQSFGDD DPAKKEPR Q ;Q12765;Q Secernin-1 SCRN1 7.54E LQSGICHLFR C9J7S3;C9JL C1;P ;P14868 Aspartate--tRNA ligase, cytoplasmic DARS 2.32E IKADPDGPEA QAEACSGER ADLVISHAGA GSCLETLEK J3QSY4;D6R C52;D6RCB9; Q9NX24 A0A096LNJ4; A0A087WX43 ;D6RE84;A0A 087WTT9;Q9 NP73-2;Q9NP73 H/ACA ribonucleoprotein complex subunit 2 Putative bifunctional UDP-Nacetylglucosamine transferase and deubiquitinase ALG13 NHP2 2.13E ALG E TKSCSGVEFS TSGSSNTDTG KVTGTLETK A2A3S1;Q5J SD2;Q5JSD1; A0A0A0MR02 ;P ;P45880;P Voltage-dependent anion-selective channel protein 2 VDAC2 2.91E ISAFGYLECS AK CTGGEVGAT SALAPK E9PQH6;Q5J R08;P08134 P ;P30050 Rho-related GTPbinding protein RhoC 60S ribosomal protein L12 RHOC 6.58E RPL E S176

177 CASQVGMTA PGTRR A0A087X1X5; B4DDF4;B4D UT8;Q ;Q99439 Calponin-2 CNN2 1.98E AVLPVTCHR LLMEQESSAC SRR Oxidation (M); H0Y7L2;Q96 N67-4;Q96N67-3;Q96N67-5;Q96N67-2;Q96N67-6;Q96N67 O ;O96011 Dedicator of cytokinesis protein 7 Peroxisomal membrane protein 11B DOCK7 4.08E PEX11B 8.68E IIYEQEGVYIH SSCGK Q8TC07-2;Q8TC07;F8 WDJ1;F8WF3 5;F8WCB5 TBC1 domain family member 15 TBC1D E AEAGEAGQA TAEAECHR O ;O95671;O N-acetylserotonin O- methyltransferase-like protein ASMTL 3.73E LCVQNSPQE AR A0A0A0MT56 ;E9PID8;E7E WR4;P ;P33240 Cleavage stimulation factor subunit 2 CSTF2 3.69E ESTGNMVTG QTVCK GTCVEGTIPK QKLTAEFEEA QTSACR AGNKHNTNTA TPFCNR LYCPVEFSK EKTACAINK LDVGNFSWG SECCTR FACFER YKVCNYGLTF TQK ESAQCVGDE FLNCK EQIDNLATEL CR Oxidation (M); Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne E7EN77;Q F5H2X1;H3B ND8;Q ;Q93009 F8W7S5;A0A 087WVV2;A0 A0A0MRV0;Q 9P2E9-3;Q9P2E9-2;Q9P2E9;A0 A087WU26 H7C1E6;Q8N DI1-3;Q8NDI1-2;Q8NDI1 P ;P52788 Q52LJ0;Q52L J0-2;E9PH82;Q8 NCA5-2;Q8NCA5 P62241 F8VVM2;Q ;Q00325 Q9Y277;E5R HE1;E5RJN6; E5RHZ6;Q9Y 277-2;E5RK27;E5 RFP6 C9J8E6;C9J0 14;C9J271;Q 9Y5X2 O95295 Condensin subunit 1 complex Ubiquitin carboxylterminal hydrolase;ubiquitin carboxyl-terminal hydrolase 7 Ribosome-binding protein 1 EH domain-binding protein 1 NCAPD2 1.37E USP7 2.35E RRBP1 3.63E EHBP1 2.46E Spermine synthase SMS 4.12E Protein FAM98B;Protein FAM98A 40S ribosomal protein S8 Phosphate carrier protein, Voltage-dependent anion-selective channel protein 3 FAM98B;FAM 98A 7.08E RPS8 2.24E SLC25A3 2.67E VDAC3 9.68E Sorting nexin-8 SNX8 5.24E SNARE-associated protein Snapin SNAPIN 8.30E S177

178 AQCPIVER DSGAASEQAT AAPNSSSS R LVIYGGMSGC R CLPPPSIR LTVVDTPGYG DAINCRDCFK NKPLGPAGSE NEIPTHVLPP CANLQAQK GALVTVGQLS CYDQAK DSCGKGEMA TGNGRR SSSSSSASAA AAAAAASSSA SCSRR ADPDGPEAQ AEACSGER KPTDGASSSN CVTDISHLVR YVLCTAPR TAPGMGDQS GCYR GCGTVLLSGP R KGTDIMYTGT LDCWRK GPTKEELCK Carbamidomet hyl (C);IAAyne M0R0F0;M0R 0R2;P46782 Q9BU23-3;Q9BU23-2;Q9BU23 A6NEM2;P ;P51610;P ;P O15269 C9IY94;C9IZ U3;C9JQJ4;C 9J938;H7C31 0;C9JB25;C9 J2Q4;B5MCX 3;Q15019;Q ;Q P ;P56159 B4DLN1;Q9U BX3;Q9UBX3-2 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed Lipase factor 2 maturation Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N- terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N- terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C- terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C- terminal chain 6 Serine palmitoyltransferase 1 RPS5 7.29E LMF2 1.45E HCFC1 1.18E SPTLC1 6.26E Septin-2 SEPT2 1.13E GDNF family receptor alpha-1 Mitochondrial dicarboxylate carrier GFRA1 1.17E MRPL12;SLC 25A E P61758 Prefoldin subunit 3 VBP1 3.33E Q07065 J3QSY4;D6R C52;D6RCB9; Q9NX24 P ;P49321;P ;H0YDS9;Q5 T624;P J3KQ69;P252 05;P Q96PK6-5;E9PB51;Q9 BQ04;Q9BWF 3 F8VUA6;G3V 203;H0YHA7; J3QQ67;Q ;Q07020 P05141 Q96TA1-2;Q96TA1 Cytoskeletonassociated protein 4 H/ACA ribonucleoprotein complex subunit 2 Nuclear autoantigenic sperm protein DNA replication licensing factor MCM3 RNA-binding protein 14;RNA-binding protein 4B;RNAbinding protein 4 60S ribosomal protein L18 ADP/ATP translocase 2;ADP/ATP translocase 2, N- terminally processed CKAP4 0.00E NHP2 6.53E NASP 2.13E MCM3 3.50E RBM14;RBM4 ;RBM4B 8.72E RPL E SLC25A5 1.28E Niban-like protein 1 FAM129B 8.74E S178

179 GLGDCLVK EVGETLLYYG CR GPFVEAEVPD VDLECPDAK VGEEFEEQTV DGRK P05141;P E7EMD0;H0Y 4R2;P16435 Q09666 P29373 ADP/ATP translocase 2;ADP/ATP translocase 2, N- terminally processed;adp/atp translocase 3;ADP/ATP translocase 3, N- terminally processed NADPH--cytochrome P450 reductase Neuroblast differentiationassociated protein AHNAK Cellular retinoic acidbinding protein 2 SLC25A5;SLC 25A6 2.81E POR 1.94E AHNAK 2.08E CRABP2 1.44E KDLLVENVPY CDAPTQKQ D6R994;Q5U 5X0 Complex III assembly factor LYRM7 LYRM7 4.56E GSDFDCELR Q5T6W1;Q5T 6W2;Q5T6W5 ;P ;P61978;P Heterogeneous nuclear ribonucleoprotein K HNRNPK 1.55E ACSNPSFLR QACLTFR F8VV69;Q6N 075;Q6N075-2 Q96SZ5 Molybdate-anion transporter 2-aminoethanethiol dioxygenase MFSD5 8.89E ADO 3.96E GILLYGPPGC GK I3L0N3;P ;P46459 Vesicle-fusing ATPase NSF 1.05E RPYEQAQ GGDGPEEQ SCSSSCAVHD LIFWR LCDPHPSKK Carbamidomet hyl (C);IAAyne Q9H1C4 B7Z4M1;O ;O ;O Q ;Q ;Q05086 Protein homolog B1 unc-93 UNC93B1 6.63E Reticulon RTN3 1.94E Ubiquitin-protein ligase E3A UBE3A 2.64E GLESTTLADK DGEIYCK P21291;E9PN D2;E9PP21 Cysteine and glycinerich protein 1 CSRP1 3.26E LTEGCSFR C9J1C5;H0Y MV8;Q71UM5 ;P S ribosomal protein S27;40S ribosomal protein S27-like RPS27L;RPS E SAPANSTV GVVK H0YFC4;Q86 YS7;Q86YS7-2;Q86YS7-3;Q86YS7-4;Q86YS7-5 C2 domain-containing protein 5 C2CD5 6.10E TGNGGAQSQ HQNVNQGPT CNVGSK TYCCDLK QVLIRSK CMPTFQFFK Oxidation (M); E9PNR0;A0A 087WZX0;Q8 6UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0 Q9Y6C9 I3L3P7;P6224 4;H3BV27;H3 BT37;I3L303;I 3L246;H3BN9 8 Carbamidomet hyl (C);IAAyne P ;P10599 B-cell CLL/lymphoma 9-like protein Mitochondrial homolog 2 carrier 40S ribosomal protein S15a BCL9L 4.57E MTCH2 1.50E RPS15A 1.61E Thioredoxin TXN 6.80E S179

180 LALFNPDVCW DR GIGDCVR NTSENKLD IQEK TLIQNCGASTI R AATGEEVSAE DLGGADLHC R VDVECPDVNI EGPEGK QITSYGETCP GLEQYAIKK O00483 P53007 E7EWK3;Q9H 2U1-3;Q9H2U1-2;Q9H2U1 B4DUR8;P ;P49368 D6RD67;D6R 9R1;D6RDF7; Q9HCC0-2;Q9HCC0 Q09666 Neuroblast differentiationassociated AHNAK P ;P50990;P Cytochrome c oxidase subunit NDUFA4 Tricarboxylate transport protein, ATP-dependent helicase DHX36 RNA T-complex protein 1 subunit gamma Methylcrotonoyl-CoA carboxylase beta chain, protein T-complex protein 1 subunit theta NDUFA4 7.14E SLC25A1 5.39E DHX E CCT3 5.71E MCCC2 3.72E AHNAK 2.56E CCT8 4.35E AITIAGVPQSV TECVK Q15365 Poly(rC)-binding protein 1 BP1 3.76E AVFPEGEE PLQLR F5GWN4;F8 WBT0;A0A0A 0MSJ2;E7EU 13;Q96P48-5;Q96P48-7;Q96P48-2;Q96P48-4;Q96P48-1;Q96P48-3;Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domaincontaining protein 1 ARAP1 3.59E GGSLESDGC PKEPAK IISNASCTTNC LAPLAK FNAHGDANTI VCNSK CPFTGNVSIR CAAPRPPSSS PEQR GCGVVKFES PEVAER NSSDLGCKE GADKR GSSCFECTHY QSFLEYR EASSSACDLP R QVFTNAEVYN CR ICPNAPDP A0A087WXF0 ;P51608;P E7EUT5;P ;P04406 Methyl-CpG-binding protein 2 Carbamidomet hyl (C);IAAyne Glyceraldehyde-3- phosphate dehydrogenase MECP2 1.19E GAPDH 2.21E P09382 Galectin-1 LGALS1 1.47E P62280;M0Q ZC5 H0YEN2;E9P QP7;H7BXH2 ;E9PKF6;Q5H 9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5 H9R7-5 P ;P52272;A0 A087X0X3 Q9NV56 Carbamidomet hyl (C);IAAyne P ;P21964 Q96SZ5 Q9UIG0-2;Q9UIG0 Q8WUZ0 40S ribosomal protein S11 Serine/threonineprotein phosphatase 6 regulatory subunit 3 Heterogeneous nuclear ribonucleoprotein M MRG/MORF4Lbinding protein Catechol O- methyltransferase 2-aminoethanethiol dioxygenase Tyrosine-protein kinase BAZ1B B-cell CLL/lymphoma 7 protein family RPS E PPP6R3 1.04E HNRNPM 4.42E MRGBP 5.74E COMT 2.07E ADO 1.45E BAZ1B 4.60E BCL7C 2.30E S180

181 member C CVLPEEDSGE LAKPK Q9Y3F4;Q9Y 3F4-2 Serine-threonine kinase receptorassociated protein STRAP 2.84E MFEDSQDSC R C9JBL0;E9P HV6;P ;P ;P ;P ;P ;P23497;P Nuclear Sp-100 autoantigen SP E VFANPEDCVA FGK LGPAPPGAAS ICRPTR CEGINISGNF YR VATRGLCAIA QAESLR LAGLTCSGAE GLARPK LVMSYVAAVC GK ASNETLVSCS SSGSDQQR TACNVEEAFI NTAK GGCWPR DLSYCLSGMY DHR CTLAEK Oxidation (M); F5H7F6;F5H6 X2;P ;P10620 P35568 M0QYS1;P P23396;P ;F2Z2S8;H0 YF32;H0YCJ7 Q8WV74 C9JUP5;C9J YW1;E7EQD9 ;E9PDF6;Q9U BC5;O ;O43795 A0A087WYH 0;J3KRC8;Q9 6N06;Q96N06-2 Q5HYI5;Q8W UD1;Q8WUD 1-2 Microsomal glutathione S- transferase 1 Insulin substrate 1 receptor 60S ribosomal protein L13a 40S ribosomal protein S3 Nucleoside diphosphate-linked moiety X motif 8, Unconventional myosin- Ia;Unconventional myosin-ib Spermatogenesisassociated protein 33 Ras-related Rab-2B protein MGST1 3.88E IRS1 1.44E RPL13A 9.09E RPS3 6.79E NUDT8 1.01E MYO1B;MYO1 A 2.31E SPATA E DKFZp313C1 541;RAB2B 8.27E Q9Y4W6 AFG3-like protein 2 AFG3L2 3.02E P52597 G3V1A4;E9P P50;E9PK25; P23528 Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N- terminally processed HNRNPF 5.20E Cofilin-1 CFL1 1.26E TTSSANNPNL MYQDECDRR Oxidation (M); H3BLZ8;Q ;Q ;Q ;Q92841 ATP- RNA Probable dependent helicase DDX17 DDX E RCPGESLINP GFK VTQNLPMKE GCTEVSLLR KPNVGCQQD SEELLK Q9BUH6 H3BQZ7;Q1K MD3 A0AVT1-3;A0AVT1 Uncharacterized protein C9orf142 Heterogeneous nuclear ribonucleoprotein U- like protein 2 Ubiquitin-like modifieractivating enzyme 6 C9orf E HNRNPUL2- BSCL2;HNRN PUL2 3.99E UBA6 1.47E AGGGPTLQC PPPSSPEK Q96N66-3;Q96N66-2;Q96N66 Lysophospholipid acyltransferase 7 MBOAT7 1.31E S181

182 SLEICHPQER DSLYVDGDCT MDIR CRDDSFFGET SHNYHKFDSE YER ASEDGESVG HCPSCQR KCGAETQHE GLELR VVVVASAAHC R NAEDCLYELP ENIR H7C5Q2;Q9Y 305-3;Q9Y305-2;Q9Y305;Q9 Y305-4 C9J712;C9J0 J7;C9JQ45;C 9J2N0;G5E9 Q6;P Carbamidomet hyl (C);IAAyne 2;P35080 H0Y8T4;D6R EM6;A8MXP9 ;P43243;D6R 991 O95833 B5MC98;Q9H CU5 B4DJC5;Q6U X07-2;Q6UX07 A0A087X2F5; Q9NZ63 Acyl-coenzyme A thioesterase 9, ACOT9 2.68E Profilin;Profilin-2 PFN2 6.68E Matrin-3 MATR3 2.85E Chloride intracellular channel protein 3 Prolactin regulatory element-binding protein Dehydrogenase/reduct ase SDR family member 13 Uncharacterized protein C9orf78 CLIC3 0.00E PREB 1.02E DHRS E C9orf E AETAANRICK H9KV75;O ;P ;P12814;O4 3707;P ;P ;K7EJH8;P ;G3V2W4;G 3V2N5 Alpha-actinin-4;Alphaactinin-1;Alphaactinin-2 ACTN1;ACTN 4;ACTN2 5.69E QAVDSPAASF CR Q9H6R4-4;Q9H6R4 Nucleolar protein 6 NOL6 1.75E GKNCVAIAAD RR A0A087WXQ 8;A0A087WY 10;A0A087W UL2;P49720 Proteasome beta type-3 subunit PSMB3 6.45E QQLPQTPPS CLK Q8IY81 pre-rrna processing protein FTSJ3 FTSJ3 1.15E LREIQLAE SR H3BP71;O ;O75150;A0 A087WTK2 E3 ubiquitin-protein ligase BRE1B RNF E TLETANCMSS QTK FGVQTDRQD KCALGWDHQ EK VFANPEDCVA FGKGENAK VTCLESGLR ALVKEQGDRI CR VDVFREDLCT K CGIPEALVQR Oxidation (M); H3BP22;H3B UV7;P ;P50416 Q ;Q14247;Q F5H7F6;F5H6 X2;P ;P10620 F8WEA6;F8W BE1;F8WAZ6; G3V0E4;O Carnitine O- palmitoyltransferase 1, liver isoform CPT1A 7.08E Src substrate cortactin CTTN 6.21E Microsomal glutathione S- transferase 1 Mitochondrialprocessing peptidase subunit beta MGST1 3.08E PMB 1.42E Q9BR76 Coronin-1B CORO1B 3.02E Q ;Q06323;Q A0A087WW7 4;O94885 Proteasome activator complex subunit 1 SAM and SH3 domaincontaining protein 1 PSME1 8.57E SASH1 2.90E S182

183 GGAARPNGP AAGNKICQFK F8VSF8;F8V WU4;F8VVK3 ;K7ERI8;K7E RQ8;P51148; P Ras-related Rab-5C protein RAB5C 2.50E GNAAVLDYCR NYLEPGKECV QPATK QELSHALYQH DAACR CDSADLRHDI DR GCYIGQELTA R Q9BV81 H7C5W9;P ;P16615 F5H2I0;F5GY 56;Q9UMS4 E9PK09;E9P QN2;E9PKI6; E9PK91;Q9N YF8-4;Q9NYF8-3;Q9NYF8-2;Q9NYF8 Q5T440 ER membrane protein complex subunit 6 Sarcoplasmic/endopla smic reticulum calcium ATPase 2 Pre-mRNA-processing factor 19 Bcl-2-associated transcription factor 1 Putative transferase CAF17, EMC6 8.29E ATP2A2 3.26E PRPF E BCLAF1 1.93E IBA E FSYICPDR C9JQV3;Q8N 1F8;Q8N1F8-2 Serine/threonineprotein kinase 11- interacting protein STK11IP 1.48E QPSDVSSEC DREGR E9PAM9;H7B ZE5;A0A0A0 MRE7;C9J41 7;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O ;O43521 Bcl-2-like protein 11 BCL2L E IAAESSENVD CPENPKIK Q32MZ4-3;Q32MZ4-2;Q32MZ4 Leucine-rich repeat flightless-interacting protein 1 LRRFIP1 1.92E ALAQEWGCP FMETSAK YNCDKMICR DKEEIVICDR MRDADADAG GGADGGDGR GGHSCR MAEGGSGDV DDAGDCSGA R VQENSAYICS RR A0A087X2C3; Q9Y3L5 M0R1M6;M0 R2S1;P62987 Carbamidomet hyl (C);IAAyne Q9NRR5-2;Q9NRR5 Q14657 H3BM63;H3B V87;Q9UH62 Q9Y3T9 Ras-related protein Rap-2c Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40 RAP2C 4.20E UBA E Ubiquilin-4 UBQLN4 1.29E EKC/KEOPS complex subunit LAGE3 Armadillo repeatcontaining X-linked protein 3 Nucleolar complex protein 2 homolog LAGE3 7.92E ARMCX3 5.30E NOC2L 4.34E S183

184 AGAHVNSED DRTSCIVR TGAESISLLEL CR LQAANDSVC R DADADAGGG ADGGDGRGG HSCR EAIEGTYIDKK CPFTGNVSIR Q9ULJ7;Q9U LJ7-2 O60216;E5R G18;E5RI01; E5RFZ5 H3BN57;Q8T DH9-3;Q8TDH9 Q14657 P62280;M0Q ZC5 Ankyrin repeat domain-containing protein 50 Double-strand-break repair protein rad21 homolog Biogenesis of lysosome-related organelles complex 1 subunit 5 EKC/KEOPS complex subunit LAGE3 40S ribosomal protein S11 ANKRD E RAD E BLOC1S5- TXNDC5;BLO C1S5 4.57E LAGE3 0.00E RPS E AQQACIEAK H3BTA3;H3B UD0;H3BS86; Q9UNE7-2;Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 5.64E GEELSCEER CVVVGDGAV GK GKGEAGNSD SMCLR P ;P31947 P63000;P607 63;P ;B1AH78;P1 5153;F8WET 9;B1AH79;G3 V4H1;G3V47 6;P84095;Q9 H4E5-2;P17081;Q9 H4E5;P60953 ;Q5JYX0;P A0A087WV66 ;P46013;P protein sigma SFN 1.56E Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 3;Rasrelated C3 botulinum toxin substrate 2;Rhorelated GTP-binding protein RhoG;Rhorelated GTP-binding protein RhoJ;Rhorelated GTP-binding protein RhoQ;Cell division control protein 42 homolog RAC1;RAC3;R AC2;RHOQ;R HOJ;RHOG;C DC E Antigen KI-67 MKI E SCEMGLQLR NCLALADDKK E9PI41;Q9NP D3 B4DJC3;O ;O ;O75367 Exosome complex component RRP41 Histone H2A;Core histone macro-h2a.1 EXOSC4 2.46E H2AFY 3.33E NVMVEPHRH EGVFICR Oxidation (M); M0QXL5;M0R 2Q4;P22087; M0R2U2;M0R 1H0;M0R2B0; M0R0P1 rrna 2'-Omethyltransferase fibrillarin FBL 1.35E SPSSQETHDS PFCLRK FKCEKQPGA GGGGGSGSG GSGAK EGCTEVSLLR MREIVHLQAG QCGNQIGAK Q8TB45-2;Q8TB45 P ;P55317 H3BQZ7;Q1K MD3 P04350;P683 71;M0R0X0;M 0R2T4;M0QY 85;M0QY37; M0QX14;M0R 042;M0R2D3; M0QYM7 DEP domaincontaining mtorinteracting protein Hepatocyte nuclear factor 3-alpha Heterogeneous nuclear ribonucleoprotein U- like protein 2 Tubulin beta-4a chain;tubulin beta-4b chain DEPTOR 7.71E FOXA1 0.00E HNRNPUL2- BSCL2;HNRN PUL2 TUBB4A;TUB B4B 1.27E E S184

185 ESLCDSPHQ NLSRPLLENK U3KPT1;C9J DJ7;C9J5L1; E7EW00;H0Y 8D9;E7ET15; O ;O15042 U2 snrnp-associated SURP motif-containing protein U2SURP 3.37E IIYGGSVTGAT CK P ;P60174;P Triosephosphate isomerase TPI1 6.77E RLDECEEAFQ GTK GDECGLALG R LLQFYAETCP APER NCMTDLLAK KPGSTPYS ER K7EMD0;K7E PX6;K7EKR3; K7ENH2;B3K Q25;K7ESG5; K9J957;P612 89;P ;P P ;P54886 I3L168;I3L3F 5;I3L4D4;I3L5 01;I3L3Y6;I3L 204;F5H6E2; O ;O ;O00159 B7Z332;B7Z5 10;H0Y8J8;Q ;Q00765 H0Y704;O ;O ;O ;O15231;O ;O ;O ;O ;O Proteasome activator complex subunit 3 Delta-1-pyrroline-5- carboxylate synthase;glutamate 5- kinase;gammaglutamyl phosphate reductase Unconventional myosin-ic Receptor expressionenhancing protein 5 PSME3 2.05E ALDH18A1 9.81E MYO1C 5.20E REEP5 3.15E Zinc finger protein 185 ZNF E NTLANSCGTG IR Q96RE7;Q96 BF6 Nucleus accumbensassociated protein 1;Nucleus accumbensassociated protein 2 NACC1;NACC E FVAGERDCP R DCGGAAQLA GPAAEADPLG R A8MXE8;Q7Z 5J4-4;Q7Z5J4-3;Q7Z5J4-2;Q7Z5J4 A0A096LNT1; A0A096LNN8; A0A096LPF9; A0A096LNV3; A0A096LP02; Q9Y508-2;Q9Y508 Retinoic acid-induced protein 1 E3 ubiquitin-protein ligase RNF114 RAI1 7.24E RNF E TTGLVGLAVC NTPHER F8WAS3;Q NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 6.16E ATDYGPEEVC ER LLACIASRPG QCGR GSAITGPVAK ECADLWPR Carbamidomet hyl (C);IAAyne O ;O75157 P62241;Q5JR 95 P62829;J3KT J3 TSC22 domain family protein 2 40S ribosomal protein S8 60S ribosomal protein L23 TSC22D2 1.29E RPS8 4.19E RPL E S185

186 RELHGQNPV VTNK LVVPATQCGS LIGKGGCK Carbamidomet hyl (C);IAAyne F8WJN3;Q ;Q16630;Q Q15365 Cleavage and polyadenylation specificity factor subunit 6 Poly(rC)-binding protein 1 CPSF6 1.38E BP1 2.25E VLPMNTGVEA GETACK P04181 Ornithine aminotransferase, ;Ornithin e aminotransferase, hepatic form;ornithine aminotransferase, renal form OAT 1.74E KTYITDPVSA APPLQPK YYEKRR C9JXK9;C9J UT4;A0A087 WZF1;Q P82921 Lipoma-preferred partner 28S ribosomal protein S21, LPP 8.92E MRPS E KVEQNSRPV SCSGR O00401 Neural Wiskott-Aldrich syndrome protein WASL 9.65E MVSTPIGGLS YVQGCTK Oxidation (M); D6RF87;E9P F16;Q96CM8-3;Q96CM8;Q 96CM8-2 Acyl-CoA synthetase family member 2, ACSF2 5.31E IICHSYLER Q9NQS7-2;Q9NQS7 Inner protein centromere INCENP 1.01E LGEMIETAYG ENFACSK Q8IYQ7 synthase- Threonine like 1 THNSL1 4.20E AIEIDEQQGC KEQER FQGIKHECQA NGPEDLNRA CIAEK QEASKPPRG CPQANR Q9NVK5-2;Q9NVK5 Carbamidomet hyl (C);IAAyne P ;P60981 Q8IVT2 FGFR1 partner 2 oncogene FGFR1OP2 2.60E Destrin DSTN 1.10E Mitotic interactor and substrate of PLK1 MISP 3.33E INISEGNCPE R F8W0G4;F8V XH9;F8W1G6 ;H3BRU6;F8V ZX2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;J3QT27;E9 PFP8;P ;P ;P ;P ;P57721;F8V TZ0;Q15365 Poly(rC)-binding protein 2;Poly(rC)- binding protein 3;Poly(rC)-binding protein 1 BP2;BP 3;BP1 9.57E ALGKHPVSCK E9PF18;A0A0 A0MSE2;Q16 836;Q ;Q Hydroxyacylcoenzyme dehydrogenase, A HADH 1.88E S186

187 LFQECCPHST DR Carbamidomet hyl (C);IAAyne Q5T6W1;Q5T 6W2;Q5T6W5 ;P ;P61978;P Heterogeneous nuclear ribonucleoprotein K HNRNPK 4.42E VGIGPGSVCT TR EGALCEENM R LVILANNCPAL R ELSFSGIE GGLR GDSEPTPGC SGLGPGGVR TGVHHYSGN NIELGTACGK ELGCLSR CCLTYCFNKP EDK ECADLWPR 2 Carbamidomet hyl (C);IAAyne H0YNS9;H0Y LB8;H0YNH0; H0YMB3;H0Y LV5;A0A087 WWM4;F8WA N9;H0YNJ6;Q 9P2T1-3;Q9P2T1;Q9 P2T1-2 GMP reductase;gmp reductase 2 GMPR2 5.00E P13639 Elongation factor 2 EEF2 1.76E E5RI99;P628 88;E5RJH3 Q9NVG8-2;Q9NVG8 F2Z3M0;E9P PN1;H0YCV5; Q8WW01-2;Q8WW01 E5RI99;P Q9Y512 P62979 P62829;J3KT J3 60S ribosomal protein L30 TBC1 domain family member 13 trna-splicing endonuclease subunit Sen15 60S ribosomal protein L30 Sorting and assembly machinery component 50 homolog Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 60S ribosomal protein L23 RPL E TBC1D E TSEN E RPL E SAMM E RPS27A 4.38E RPL E VTFSCAAGFG QR E7EWF7;E7E X90;Q ;Q ;Q ;Q ;Q ;Q14203 Dynactin subunit 1 DCTN1 6.36E ICDECNYGSY QGR VFFIQACQGD NYQK Carbamidomet hyl (C);IAAyne Q7RTV0 H7C0E2;Q ;Q ;Q14790;Q ;Q PHD finger-like domain-containing protein 5A Caspase-8;Caspase-8 subunit p18;caspase- 8 subunit p10 PHF5A 6.17E CASP8 1.21E CNLACTPPR Carbamidomet hyl (C);IAAyne F6S6P2;X6R EW1;P ;P ;P ;P46379;P Large proline-rich protein BAG6 BAG6 7.90E AEGLATGFCR YLVLDCVPEE R C9J9N8;C9JE X8;C9IYN7;Q 0PNE2-2;Q0PNE2 O ;O14776 Elongator protein 6 complex Transcription elongation regulator 1 ELP6 1.80E TCERG1 5.79E S187

188 KQESSCPSQ NLK Q8NEU8-2;Q8NEU8;Q 8NEU8-3 DCC-interacting protein 13-beta APPL2 2.98E GDDCLMK A0A087WZT9 ;P11801 Serine/threonineprotein kinase H1 PSKH1 3.51E AVASQLDCNF LK VEEIAASKCR A0A087X2I1; P62333;H0YJ S8;H0YJC0 M0R117;Q02 543;M0R0P7; M0R3D6;M0R 1A7 26S protease regulatory subunit 10B 60S ribosomal protein L18a PSMC6 2.13E RPL18A 1.02E YKWCEYGLTF TEK A2A3S1;Q5J SD2;Q5JSD1; A0A0A0MR02 ;P ;P45880;P Voltage-dependent anion-selective channel protein 2 VDAC2 1.25E KAQCPIVER ECLPLIIFLR NCTAGAVYTY HEK DLAGCIHGLS NVK LKSYCNDQST GDIK ICGYHSTISN ASYFQCVQR KSPSSDSWT CADTSTER GAVEKGEELS CEERNLLSVA YK EMASCITQR M0R0F0;M0R 0R2;P46782 A6NH36;P M0R3B2;A0A 075B6F9;Q9Y 314;M0R1T7; M0QX85;M0R 1K2 P ;P48735 P00492 Q8NFR3 P ;P30281 H0YIQ0;E5R HH7;F8VWH9 ;Q8N6T3-4;Q8N6T3-5;Q8N6T3;Q8 N6T3-2 P ;P31947 Q969E8 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed 40S ribosomal protein S4, X isoform Nitric oxide synthaseinteracting protein Isocitrate dehydrogenase [NADP], Hypoxanthine-guanine phosphoribosyltransfer ase Serine palmitoyltransferase small subunit B G1/S-specific cyclin- D3 ADP-ribosylation factor GTPase-activating protein 1 RPS5 3.51E RPS4X 1.39E NOSIP 8.41E IDH2 5.38E HPRT1 1.25E SPTSSB 8.86E CCND3 1.05E ARFGAP1 2.77E protein sigma SFN 0.00E Pre-rRNA-processing protein TSR2 homolog TSR2 2.17E VACAEEWQE SR AVCEADQSH GGPR O ;O75663 F8VNX8;O TIP41-like protein TIPRL 2.83E TRAF-type zinc finger domain-containing protein 1 TRAFD1 0.00E KSEKGPVCW R E9PDH6;G3X AL2;Q ;Q ;Q ;Q15910;Q Histone-lysine N- methyltransferase EZH2 EZH2 1.07E TTASEPVEQS EATSKDCSR Q15007 Pre-mRNA-splicing regulator WTAP WTAP 6.62E CQLQQAAAL NAQHK Q96DF8 Protein DGCR14 DGCR E LICLVTGSPSI R Q6PI48 Aspartate--tRNA ligase, DARS2 3.32E S188

189 SASVAPFTCK NALANPLYCP DYR IMKDLDQCRD GK AIANECQANFI SIK TSNKPLMIIHH LDECPHSQAL K QGCDCECLG GGR GSAFAIGSDG LCCQSR TVFAEHISDE CKR P ;P49790;P H3BP04;H3B SJ9;H3BRG4; P22695 Nuclear pore complex protein Nup153 Cytochrome b-c1 complex subunit 2, NUP E UQCRC2 2.72E P60903 Protein S100-A10 S100A E P55072 C9J3E2;B5M C07;O Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne Q9NRX4-2;Q9NRX4 F1T0B3;A0A0 87X2G1;Q G5E9G0;P39 023;B5MCW2 ;H7C422;F8W CR1;H7C3M2 Transitional endoplasmic reticulum ATPase Anterior gradient protein 2 homolog 14 kda phosphohistidine phosphatase ATP-dependent helicase DDX1 RNA 60S ribosomal protein L3 VCP 8.54E AGR2 8.47E PHPT1 3.66E DDX1 1.61E RPL3 0.00E AGEGTYALDS ESCMEK LCCPATAPQE APAPEGR ALLLLCGEDD MCFVDPVR ATILDLSCNK LVMSYVAAVC GK APPPSLTDCI GTVDSR B3KXD6;B5M CF9;O ;O00541 M0QXZ5;Q96 B54 D6RBE9;D6R BL5;P08758 Q9BQ24;Q9B Q24-2 Q96AG4 C9JUP5;C9J YW1;E7EQD9 ;E9PDF6;Q9U BC5;O ;O43795 Q9NZZ3-2;Q9NZZ3 Pescadillo homolog PES1 8.88E Zinc finger protein 428 ZNF E Annexin;Annexin A5 ANXA5 6.87E Carbamidomet hyl (C);IAAyne Oxidation (M); Zinc finger FYVE domain-containing protein 21 Leucine-rich repeatcontaining protein 59 Unconventional myosin- Ia;Unconventional myosin-ib Charged multivesicular body protein 5 ZFYVE E LRRC E MYO1B;MYO1 A 2.71E CHMP5 1.90E GGCIIR P ;P52209;K7 ELN9 6-phosphogluconate dehydrogenase, decarboxylating PGD 2.11E YRNPVSQCM R Oxidation (M); K7EJ99;A0A0 A0MSV7;K7E JM5;A0A087 WX29;K7EN9 4;B1AKP7;G3 V162;A0A087 X260;A0A087 WYY0;Q TAR DNA-binding protein 43 TARDBP 7.27E ECNPPNSQP ASYQR C9JM79;E9P G73;Q ;Q13427 Peptidyl-prolyl cistrans isomerase G PPIG 4.26E AADETLCQTK P ;P49916 DNA ligase 3 LIG3 6.46E KGVLFGVPGA FTPGCSK P ;P ;P30044 Peroxiredoxin-5, PRDX5 1.41E S189

190 KRAGDELAYN SSSACASSR RRCPGESLIN PGFK Q86Y37;Q86 Y37-4 Q9BUH6 CDK2-associated and cullin domaincontaining protein 1 Uncharacterized protein C9orf142 CACUL1 4.64E C9orf E SSPGLSDTIF CR AALAACPSSP FPPAMPR Q9H8M7-2;Q9H8M7 Q8N2G8-3;Q8N2G8 Protein FAM188A FAM188A 1.33E GH3 domaincontaining protein GHDC 1.20E CSPSSSSINN SSSKPTK H0YAT6;O ;O15265;O Ataxin-7 ATXN7 2.49E GLCGAIHSSIA K KENQWCEEK P ;P36542 E5RJR5;P ATP synthase subunit gamma, S-phase kinaseassociated protein 1 ATP5C1 4.68E SKP1 1.39E AGKPGATK R ARREDFCPR ELCELKPK TGQYSGIYDC AK A0A0A0MQR 2;Q9BY42 Q9H0W8-2;Q9H0W8 E9PIZ4;E9PS D5;E9PPQ5; Q9UHD1-2;Q9UHD1 Q6NUK1-2;Q6NUK1 Protein RTF2 homolog RTFDC1 5.79E Protein SMG9 SMG9 3.21E Cysteine and histidinerich domain-containing protein 1 Calcium-binding carrier protein SCaMC-1 CHORDC1 3.13E SLC25A E CVSVQTDPTD EIPTKK P ;P ;P ;P ;P ;P ;P ;P ;P18583;P Protein SON SON 1.14E GPSLQGDLAV SGDIKCPK Q09666 Neuroblast differentiationassociated AHNAK protein AHNAK 1.47E SCSGVEFSTS GSSNTDTGK A2A3S1;Q5J SD2;Q5JSD1; A0A0A0MR02 ;P ;P45880;P Voltage-dependent anion-selective channel protein 2 VDAC2 3.49E SLCIGATYDV TDSR IKNCLNPQFS K B3KXD6;B5M CF9;O ;O00541 E5RFT7;A0A 087WUS8;A0 A087WXR6;E 5RHZ0;A0A0 87WYQ3;O Pescadillo homolog PES1 7.08E Copine-3 CPNE3 2.16E FRDQDLASC DRDR LKESAQCVG DEFLNCK Carbamidomet hyl (C);IAAyne Q96HJ9-2;Q9Y383-3;Q9Y383-2;Q9Y383 C9J8E6;C9J0 14;C9J271;Q 9Y5X2 UPF0562 protein C7orf55;Putative RNAbinding protein Luc7- like 2 C7orf55;LUC7 L2 1.48E Sorting nexin-8 SNX8 1.84E S190

191 DSLYVDGDCT MDIR YLAECR Oxidation (M); C9J712;C9J0 J7;C9JQ45;C 9J2N0;G5E9 Q6;P ;P35080 E9PR92;E5R HK3;E5RJ86; Q9NVT9 Profilin;Profilin-2 PFN2 1.50E Armadillo repeatcontaining protein 1 ARMC1 3.56E AAAPAPVSEA VCR E7EQ12;A0A 0A0MR45;E7 EQA0;H0Y7F 0;H0YD33;H0 Y9H6;E9PDE 4;E7ES10;E9 H5;E7EVY 3;B7Z574;P ;P ;P ;P ;P20810;P ;P ;P ;P ;P Calpastatin CAST 4.65E DILKEMFPYE ASTPTGISAS CR Oxidation (M); H0YJH7;G5E 972;P ;P42167 Lamina-associated polypeptide 2, isoforms beta/gamma;thymopo ietin;thymopentin TMPO 5.80E KSYESSEDCS EAAGSPAR ALDLDSSCK VVLLGEGCVG K K7ER58;Q6P 6C2-3;Q6P6C2 H0YGI8;P ;P31948;P Q9UL25 RNA demethylase ALKBH5 Stress-inducedphosphoprotein 1 Ras-related Rab-21 protein ALKBH5 4.04E STIP1 1.83E RAB E KCSTPEEIK P ;P60981;F6 RFD5 Destrin DSTN 4.45E AKECEPPSAG AAVTARPGQE IR Q9C0E8-3;Q9C0E8-2;Q9C0E8;Q9 C0E8-4 Protein lunapark LNP 2.41E ETCSTLAESP R Q6P2E9-2;Q6P2E9 Enhancer of mrnadecapping protein 4 EDC4 3.61E QRPLTASLQC NSTAQTEK C9JUJ0;Q9U FW8 CGG triplet repeatbinding protein 1 CGGBP1 3.43E LLCGLLAER P14174 Macrophage migration inhibitory factor MIF 4.89E IANLGSCNDS KLEFR Q9HCY8 Protein S100-A14 S100A E ADPAIKEPLPV EDVCPK I3L2A2;I3L2N 7;Q ;Q92667;I3L 3K1;I3L364;I3 L0K6 A-kinase anchor protein 1, AKAP1 2.37E GNEFEDYCLK R APPTACYAGA APAPSQVK Q8IV96;P Probable dependent helicase DDX6 P ;P ;P17676 ATP- RNA CCAAT/enhancerbinding protein beta DDX6 2.88E CEBPB 3.38E LLMEQESSAC SRR O ;O96011 Peroxisomal membrane protein 11B PEX11B 1.13E S191

192 DCLADVDTKP AYQNLR Q8NFC6;Q96I K1-2;Q96IK1 Biorientation of chromosomes in cell division protein 1-like 1;Biorientation of chromosomes in cell division protein 1 BOD1L1;BOD E KAIEIDEQQG CKEQER Q9NVK5-2;Q9NVK5 FGFR1 partner 2 oncogene FGFR1OP2 2.05E IAVAAQNCYK P ;P60174 Triosephosphate isomerase TPI1 6.34E SLDQTSPL VLVR VLVQHCPAR VCNYGLTFTQ K GATVDKTVCK K Q6XZF7 I3VM54;Q9Y2 K7-4;Q9Y2K7-5;Q9Y2K7-2;Q9Y2K7 Q9Y277;E5R HE1;E5RJN6; E5RHZ6;Q9Y 277-2;E5RK27;E5 RFP6 I3L0J9;Q6P2 Q9 Dynamin-binding protein Lysine-specific demethylase 2A Voltage-dependent anion-selective channel protein 3 Pre-mRNAprocessing-splicing factor 8 DNMBP 4.01E KDM2A 2.42E VDAC3 9.01E PRPF8 8.14E AQNTWGCGN SLR Q5TCI8;P ;P ;P ;P ;P ;P02545 Prelamin-A/C;Lamin- A/C LMNA 1.05E GRAAGPS REEELAAVR Q9BU76-2;Q9BU76-3;Q9BU76-4;Q9BU76 Multiple myeloma tumor-associated protein 2 MMTAG2 3.75E QVVDCQLAD VNNIGK P ;P28838 Cytosol aminopeptidase LAP3 4.48E ALVDGTQV R LFNTAVCESK DLSDTVR AKFENLCK GLYDGPVCEV SVTPK E7EPB3;P Q9BXJ9 Q58FF8;P Q ;Q S ribosomal protein L14 N-alphaacetyltransferase 15, NatA auxiliary subunit Putative heat shock protein HSP 90-beta 2;Heat shock protein HSP 90-beta Dihydropyrimidinaserelated protein 2 RPL E NAA E HSP90AB2P; HSP90AB1 2.21E DPYSL2 2.05E DSSSLSSCTS GILEER TCLDNLASK CAGPTPEAEL QALAR EIADGLCLEV EGK Q9H3Q1-2;Q9H3Q1 H0YLE8;P Q15050 J3KPG2;E9PJ F7;Q5W0H4; P13693 Cdc42 effector protein 4 Ras GTPaseactivating-like protein IQGAP1 Ribosome biogenesis regulatory protein homolog Translationallycontrolled protein tumor CDC42EP4 8.11E IQGAP1 1.10E RRS1 2.19E TPT1 5.13E KTATAVAHCK M0R210;P622 49;M0R3H0;Q 6IPX4 40S ribosomal protein S16 RPS E KCPFTGNVSI R P62280;M0Q ZC5 40S ribosomal protein S11 RPS E S192

193 YQEAAPNVAN NTGPHAASCF GAK C9JZR2;O Catenin delta-1 CTNND1 4.58E SQGGEEEGP LSDKCSR TSSVSNPQDS VGSSR E9PR76;E9P SH4;Q9H063 F5H836;F5GZ 78;P ;P49023;P Repressor of RNA homolog polymerase III transcription MAF1 MAF1 4.63E Paxillin PXN 2.05E QPAIMPGQSY GLEDGSCSY KDFSESR QAVLGAGLPI STTTINKV CASGMK TTCMSSQGS DDEQIKR EVCGFAPYER R SCTPSPDQIS HR LCSSSDTLVS EGEENQKPK CALGWDHQE K AAAGELQEDS GLCVLAR AALASAHQCH PLPR GLTDLSACK CSASCCEDS QASMK VGVGTCGIAD KPMTQYQDT SK IAVYSCPFDG MITETK SAVETQANNL ICR ERICSEEERA K GLCAIAQAES LR LVVPATQCGS LIGK KGDECELLGH SK Carbamidomet hyl (C);IAAyne 2 Carbamidomet hyl (C);IAAyne Oxidation (M); M0QYT0;M0 QXS5;P ;P14866 P24752;E9PK F3;H0YEL7;P E7EW69;E7E X04;B5ME97; Q9P0V9;Q9P 0V9-2;C9JEW2;C9 JNR7 J3QSB5;Q9Y 3U8 C9J6P4;Q7Z2 W4-2;Q7Z2W4;Q 7Z2W4-3 Heterogeneous nuclear ribonucleoprotein L Acetyl-CoA acetyltransferase, HNRNPL 2.16E ACAT1 3.60E Septin-10 SEPT E S ribosomal protein L36 Zinc finger CCCH-type antiviral protein 1 RPL E ZC3HAV1 3.37E Q5T0W9 Protein FAM83B FAM83B 2.79E Q ;Q14247;Q H0Y4Y4;Q96 C19 Q9NWZ5-3;Q9NWZ5-4;Q9NWZ5 O00567;Q5JX T2 C9JF51;E7E QY1;Q96C01 O75940 P ;P50990;P Src substrate cortactin CTTN 9.51E EF-hand domaincontaining protein D2 Uridine-cytidine kinase-like 1 EFHD2 2.74E UCKL1 9.87E Nucleolar protein 56 NOP E Protein FAM136A FAM136A 0.00E Survival of motor neuron-relatedsplicing factor 30 T-complex protein 1 subunit theta SMNDC1 2.36E CCT8 1.04E O75362 Zinc finger protein 217 ZNF E C9JRZ6;F8W AR4;Q9NX63 P23396;P ;F2Z2S8;H0 YF32;H0YCJ7 Q15365 P49411 MICOS complex subunit MIC19 40S ribosomal protein S3 Poly(rC)-binding protein 1 Elongation factor Tu, CHCHD3 3.21E RPS3 0.00E BP1 3.07E TUFM 6.20E S193

194 SCTPYELR STLTDSLVCK TILTLTGVSTL GDVKNNQES DCVSK AQGTDNSDQ SEICK SVSVTAAGQC R YSYVCPDLVK MAEGGSGDV DDAGDCSGA R LQFHDVAGDI FHQQCK LLMEQESSAC SR EQVPSLGSNV ACGLAYTDYH K Oxidation (M); Oxidation (M); Q ;Q ;Q92466 DNA damage-binding protein 2 DDB2 1.35E P13639 Elongation factor 2 EEF2 0.00E H3BV17;A6N DG6 G3V4R7;A0A 087WXK9;Q V5LU97;O ;O00291 B4DXW1;P H3BM63;H3B V87;Q9UH62 P11413;P ;P O ;O96011 M0R026;A1L0 T0 Phosphoglycolate phosphatase Thyroid receptorinteracting protein 11 Huntingtin-interacting protein 1 PGP 0.00E TRIP E HIP1 1.26E Actin-related protein 3 ACTR3 2.23E repeat- X-linked Armadillo containing protein 3 Glucose-6-phosphate 1-dehydrogenase Peroxisomal membrane protein 11B Acetolactate synthaselike protein ARMCX3 4.46E G6PD 1.57E PEX11B 5.95E ILVBL 3.81E GSSPTPSP VQPSK H0YBY0;G5E A18;A0A0A0 MTC4;A0A0A 0MTD1;F8VPI 7;E7EPX0;A0 A0A0MTC6;E 7EVJ4;E9PH6 2;A0A0A0MT C5;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 Double-stranded RNAbinding protein Staufen homolog 2 STAU2 6.17E SVVCQESDLP DELLYGR IAVYSCPFDG MITETK VLPSCDLAR SSGCFPNMA AK YATSCYSCCP R HGFCGIPITDT GR FACHSASLTV R SDFGSCPPEE QPR Q9NS86 LanC-like protein 2 LANCL2 2.82E P ;P50990;P Q96LJ7 Q96I24 K7E2;K7E S73;K7EN91; Q13057;Q E7ETK5;H0Y 4R1;P12268 C9IZL7;C9JY S8;Q ;Q15233 Q8WZ82 T-complex protein 1 subunit theta Dehydrogenase/reduct ase SDR family member 1 Far upstream elementbinding protein 3 2 Carbamidomet hyl (C);IAAyne Bifunctional coenzyme A synthase;phosphopan tetheine adenylyltransferase;d ephospho-coa kinase Inosine-5'- monophosphate dehydrogenase 2 Non-POU domaincontaining octamerbinding protein Ovarian cancerassociated gene 2 protein CCT8 2.00E DHRS1 9.18E FUBP3 2.38E COASY 4.46E IMPDH2 2.35E NONO 1.12E OVCA2 2.71E S194

195 EMQNLSFQD CYSSK SYCNDQSTG DIK SQSASYYPVC HSK P30084 P00492 A0A087WUE 1;Q9HCD6;Q 9HCD6-2 Enoyl-CoA hydratase, Hypoxanthine-guanine phosphoribosyltransfer ase ECHS1 1.40E HPRT1 2.33E Protein TANC2 TANC2 2.13E SGIQPLCPER P42166 Lamina-associated polypeptide 2, isoform alpha;thymopoietin;t hymopentin TMPO 2.24E ESPVSAPLEG LICR O ;O75376;A0 A088AWL3 Nuclear receptor corepressor 1 NCOR1 2.29E ALVDGTQV RR E7EPB3;P S ribosomal protein L14 RPL E CAAEREEPPE QR Q9GZP4-2;Q9GZP4 PITH domaincontaining protein 1 PITHD1 9.27E QDKCALGWD HQEK Q ;Q14247;Q Src substrate cortactin CTTN 1.39E ACIAEK P ;P60981 Destrin DSTN 3.07E DLAGAPPGEV VGCFTPQSR Q9Y446;Q9Y Plakophilin-3 PKP3 1.97E VCEEIAIIPSK H0YN73;H0Y N88;A0A075B 716;P0CW22; P S ribosomal protein S17-like;40S ribosomal protein S17 RPS17;RPS17 L 3.13E ARGGCPGGE ATLSQPPPR ELVNAQCAK ATGHSGGGCI SQGR VLPSCDLARR VNDSERNPNL SCKR P20290 I3L2J1;Q9Y3 C7 I3L407;I3L3W 5;I3L139;Q9H A64 Q96LJ7 E9PQ42;E9P JD7;Q6ZMK1-2;Q6ZMK1 Transcription factor BTF3 Mediator of RNA polymerase II transcription subunit 31 BTF3 1.15E MED E Ketosamine-3-kinase FN3KRP 3.53E Dehydrogenase/reduct ase SDR family member 1 Cysteine and histidinerich protein 1 DHRS1 1.26E CYHR1 8.06E YYTSASGDE MVSLKDYCTR P07900;P Heat shock protein HSP 90-alpha HSP90AA1 3.19E IACDEEFSDS EDEGEGGRR Q ;Q92769 Histone deacetylase 2 HDAC2 1.22E GAVEKGEELS CEER P ;P protein sigma SFN 0.00E SVDKNKD R Q7Z6E9-4;Q7Z6E9-2;Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 2.71E ETQAQACPQ EGTEAHGAR GCPPVFNTLR E9PIH6;Q8N3 D4 Q9BXJ9;Q9B XJ9-4 EH domain-binding protein 1-like protein 1 N-alphaacetyltransferase 15, NatA auxiliary subunit EHBP1L1 2.48E NAA E SEFYANEACK R G3V4F2;A0A 087X0W7;A0 A087WT95;P ;Q86TX2;P Acyl-coenzyme A thioesterase 2, ;Acylcoenzyme A thioesterase 1 ACOT1;ACOT E S195

196 VFSANSTAAC TELAKR Q14558;Q Phosphoribosyl pyrophosphate synthase-associated protein 1 PRPSAP1 5.75E IVQTLCTVR Q96D53;M0R 362;M0R0L2; M0R3F7;M0R 001;M0R011 domain- protein AarF containing kinase 4 ADCK4 3.90E LIIAGTSCYSR P ;P ;P34896;P Serine hydroxymethyltransfer ase, cytosolic SHMT1 1.79E DAYCCAQQG KR VVQHLCQR Carbamidomet hyl (C);IAAyne Q9NR33 Q8WUY1;H0 YAR9 DNA polymerase epsilon subunit 4 POLE4 2.86E Protein THEM6 THEM6 3.16E LTEGCSFRR C9J1C5;H0Y MV8;Q71UM5 ;P S ribosomal protein S27;40S ribosomal protein S27-like RPS27L;RPS E SEDEAGCSS VDEESYK ICPVEFNPNF VAR RVPQCPSGR INDALSCEYE CR LTWHSCPED EAQ Carbamidomet hyl (C);IAAyne Q7L4I2-2;Q7L4I2 F5GX77;Q9UI 30-2;Q9UI30 Q16186 Q52LJ0;Q52L J0-2 Q13185 Arginine/serine-rich coiled-coil protein 2 Multifunctional methyltransferase subunit TRM112-like protein Proteasomal ubiquitin receptor ADRM1 RSRC2 2.47E TRMT E ADRM1 1.02E Protein FAM98B FAM98B 4.47E Chromobox homolog 3 protein CBX3 2.93E GIIYNEDN GIIK P36578;H3B M89 60S ribosomal protein L4 RPL4 5.63E SGGLQTPECL SR EGCTVSPETI SLNVK ATYDKLCK A4D1Z4;P ;P85037 E5KLK1;E5KL J6;E5KLJ9;E5 KLJ5;O60313; O P62851 Forkhead box protein K1 Dynamin-like 120 kda protein, ;Dynami n-like 120 kda protein, form S1 40S ribosomal protein S25 KIAA0415;FO XK1 3.17E OPA1 3.15E RPS E SCLLLR YGDSEFTVQS TTGHCVHMR MCLFAGFQR SVLGGDCLLK Oxidation (M); E7END7;P ;P62820;A0 A087WTI1;E9 PLD0;P ;Q9H0U4;Q P52597 Q ;Q00839 P41240 Ras-related protein Rab-1A;Ras-related protein Rab- 1B;Putative Rasrelated protein Rab-1C Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N- terminally processed Heterogeneous nuclear ribonucleoprotein U Tyrosine-protein kinase CSK RAB1A;RAB1 B;RAB1C 3.61E HNRNPF 1.17E HNRNPU 2.10E CSK 3.65E S196

197 SLCLGPALIHT AK VLTMPETCR CVEQKTDALG K Q ;Q ;Q99643 A0A087WW6 6;Q ;Q99460 H0YEW4;A8 MRA7;I3L448; Q5TC12-3;Q5TC12 Succinate dehydrogenase cytochrome b560 subunit, 26S proteasome non- ATPase regulatory subunit 1 ATP synthase F1 complex assembly factor 1 SDHC 1.19E PSMD1 4.73E ATPAF1 7.40E GAYRDCLGRL DLQYAK Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E9 PMV1 Plectin PLEC 5.51E LLMEQESSAC SR O ;O96011 Peroxisomal membrane protein 11B PEX11B 7.26E KAADETLCQT K P ;P49916 DNA ligase 3 LIG3 2.12E TLETANCMSS QTK H3BP22;H3B UV7;P ;P50416 Carnitine O- palmitoyltransferase 1, liver isoform CPT1A 3.69E CQLEINFNTL QTK LCVQNSHQE AR DRVVVVSHD ENLCR DDDRTPGLH GDCDDDKYR LSKHCSQVDS VR ESCTAHAASQ AATQR H9KV75;O ;P ;P12814;O4 3707;P ;P ;K7EJH8;P ;F6THM6;A0 A087WSZ2;P 35609;Q Q9H0L4 Alpha-actinin-4;Alphaactinin-1;Alphaactinin-2;Alphaactinin-3 Q7L5L3-1;Q7L5L3 O95159 Q ;Q14247;Q ;H7C314 Q9NYZ3 Cleavage stimulation factor subunit 2 tau variant Glycerophosphodieste r phosphodiesterase domain-containing protein 3 Zinc finger protein-like 1 ACTN1;ACTN 4;ACTN2;ACT N3 2.94E CSTF2T 8.30E GDPD3 2.77E ZFPL1 1.97E Src substrate cortactin CTTN 1.61E G2 and S phaseexpressed protein 1 GTSE1 5.68E AVYTQDCPLA AAK NILGGTVFRE PIICK RPPEACEELR ADIDVSGPKV DVECPDVNIE GPEGK H3BPK7;P49 588;P P ;P48735 Q86Y56-2;Q86Y56 Q09666 Alanine--tRNA ligase, cytoplasmic Isocitrate dehydrogenase [NADP], HEAT repeatcontaining protein 2 Neuroblast differentiationassociated protein AHNAK AARS 1.46E IDH2 7.75E HEATR2 2.44E AHNAK 4.49E S197

198 SRPTSEGSDI ESTEPQKQC SK D6RFF0;H0Y A82;Q4G0J3; Q4G0J3-3 La-related protein 7 LARP7 2.13E FKQLETEQRE EQCR H0Y5D3;H0Y 3M0;Q13371 Phosducin-like protein PDCL 1.30E LGEWVGLCK P S ribosomal protein S12 RPS E SGAELALDYL CR DAYCCAQQG K Carbamidomet hyl (C);IAAyne H7C0T1;H7C 2R9;C9JQV0; Q9BRJ6 Q9NR33 Uncharacterized protein C7orf50 DNA polymerase epsilon subunit 4 C7orf E POLE4 5.54E TEEILVK A0A087WWY 3;Q5HY54;Q6 0FE5;P ;P21333 Filamin-A FLNA 4.02E LVIVGDGACG K E9PQH6;Q5J R08;P08134; E9PLA2;C9J1 T2;C9JRM1;Q 5JR06;Q5JR0 7;E9PN11;C9 JNR4;C9JX21 ;Q5JR05;U3K QA9;U3KQV3 ;P61586 Rho-related GTPbinding protein RhoC;Transforming protein RhoA RHOC;RHOA 7.23E ALLVTASQCQ QPAENK KCPSTHSEEL HDCIQK KLMEECKR KSYESSEDCS EAAGSPARK FCAFGGNPP VTGPR Q5T0R7;Q5T 0R6;Q5T0R5; Q5T0R4;Q5T 0R3;Q5T0R2; Q5T0R1;Q5T 0R9;Q ;Q01518 D3DT44;P Q9P0L0;Q9P 0L0-2 K7ER58;Q6P 6C2-3;Q6P6C2 O15446;O Adenylyl cyclaseassociated protein;adenylyl cyclase-associated protein 1 Glutamate--cysteine ligase regulatory subunit Carbamidomet hyl (C);IAAyne Vesicle-associated membrane proteinassociated protein A RNA demethylase ALKBH5 DNA-directed RNA polymerase I subunit RPA34 CAP1 2.76E GCLM 5.77E VAPA 5.77E ALKBH5 6.90E CD3EAP 1.29E SGCALTDAVA PGNK H3BMJ8;H3B SP8;Q9BQ70; H3BS87;Q9H 7D3;H3BTU3 Transcription factor 25 TCF25;NULP1 2.16E NVDRYCEAA R B8ZZR0;F8W BF5;A0A087 WVK0;P4975 9;P Dual specificity protein kinase CLK1 CLK1 2.25E ALLYLCGGDD MKLNISFPAT GCQK CAPSAGSPAA AVGR Oxidation (M); P07355;A6N MY6;P P62753;A2A3 R7 Q7L2J0 Annexin A2;Putative annexin A2-like protein 40S ribosomal protein S6 7SK snrna methylphosphate capping enzyme ANXA2;ANXA 2P2 1.87E RPS6 5.09E MEE 8.59E SKTSNKPLMII HHLDECPHS C9J3E2;B5M C07;O95994 Anterior gradient protein 2 homolog AGR2 1.11E S198

199 QALK SDCKEFSSEA R I3L2D5;I3L23 9;I3L0K7;Q ;Q12931 Heat shock protein 75 kda, TRAP1 2.30E KICSHSAPEQ QAR O75683 Surfeit locus protein 6 SURF6 1.62E CSTPEEIKKR ATEGMVVADK NCSK P ;P60981;F6 RFD5 Q99436;Q5T BG5;Q Destrin DSTN 2.97E Proteasome subunit beta type- 7;Proteasome subunit beta type PSMB7 1.19E VIGSGCNLDS AR P ;P ;P00338;P ;A0A087WU M2;P ;Q6ZMR3;F5 H5G7;F5H15 5;A8MW50;G 3XAP5;F5H24 5;P07864;P L-lactate dehydrogenase A chain;l-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase;llactate dehydrogenase C chain;l-lactate dehydrogenase B chain LDHA;LDHAL 6A;LDHC;LDH B 8.03E KPYCNAHYPK F6S2S5;Q148 47;Q ;C9J9W2;O LIM and SH3 domain protein 1 LASP1 9.53E GKDCAVIVTQ K VAAASGHCG AFSGSDSSR RGIIYNED NGIIK RCEKAEEK CYQLPPGAR IVAAHNKCPR LPLEQCTGSS R ATSAGSSPSC SLAGR YMACCLLYR TYDPSGDSTL PTCSK KPAFTEASCP LSR EAIICK G3V3U4;G3V 3I1;G3V295;G 3V5Z7;P ;P60900 Q9NZB2;Q9N ZB2-6 P36578;H3B M89 Q9Y605 P13716;P A6ND22;Q9Y 3D3-2;Q9Y3D3 Q9HCU4 Q9BXB5-2;Q9BXB5 Carbamidomet hyl (C);IAAyne P ;P ;P68366;P68 363;A6NHL2-2;A6NHL2;F5 H5D3;Q9BQE 3 Proteasome subunit alpha type;proteasome subunit alpha type-6 Constitutive coactivator of PPARgamma-like protein 1 60S ribosomal protein L4 MORF4 familyassociated protein 1 Delta-aminolevulinic acid dehydratase 28S ribosomal protein S16, Cadherin EGF LAG seven-pass G-type receptor 2 Oxysterol-binding protein-related protein 10 Tubulin alpha-1b chain;tubulin alpha-4a chain;tubulin alpha chain-like 3;Tubulin alpha-1c chain PSMA6 3.29E FAM120A 6.37E RPL4 1.65E MRFAP1 8.87E ALAD 2.80E MRPS E CELSR2 1.78E OSBPL E TUBA1B;TUB A4A;TUBAL3; TUBA1C 4.65E Q9Y2X3 Nucleolar protein 58 NOP E A0A0A0MTP6 ;O ;O15357 O75874;C9J4 N6 Phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase 2 Isocitrate dehydrogenase [NADP] cytoplasmic INPPL1 5.13E IDH1 5.73E S199

200 VLNEECDQN WYKAELNGK J3KT38;J3QR L5;P ;P62993 Growth factor receptorbound protein 2 GRB2 2.19E AVSTGDCGQ VLR A0A0A0MSU 2;Q6PJG2;H7 C1L3 ELM2 and SANT domain-containing protein 1 ELMSAN1 1.00E AYGGSMCAK KRGCSHPGG SADGPAK VQENSAYICS R ASCQPQPLE R AAGAPGAAC RPGCSQK GGCPGGEAT LSQPPPR Carbamidomet hyl (C);IAAyne P49207 E7EUB5;Q ;Q ;Q01831 Q9Y3T9 A0A087WTV1 ;E7ET92;Q9H 1P3-2;Q9H1P3 O95685 P S ribosomal protein L34 DNA repair protein complementing XP-C cells Nucleolar complex protein 2 homolog Oxysterol-binding protein;oxysterolbinding protein-related protein 2 Protein phosphatase 1 regulatory subunit 3D Transcription BTF3 factor RPL E X 6.57E NOC2L 4.85E OSBPL2 1.09E PPP1R3D 1.12E BTF3 2.52E AACLESAQEP AGAWGNK C9JBS3;C9JE J8;A0A088A WM1;C9JHN6 ;C9JT62;C9J HS7;C9JK79; C9JHZ8;C9JE S8;C9JZI8;C9 J5E5;C9JIZ1; A0A024R4E5 HDLBP 5.35E EKCSIAVDISE NLKEK SCGKDGFHIR ACYGVLR VKNQLKETTE AACR SIIDCK EVIAVSCGPA QCQETIR AGSDGAKIGN CPFSQR Carbamidomet hyl (C);IAAyne Q5VUC9;Q5V UC3;P78345 F8W7C6;A0A 087WV22;X1 WI28;P27635; B8A6G2;A6Q RI9 P23396;P ;E9PL09;H0 YEU2 E9PFN5;Q9Y 2Q3-4;Q9Y2Q3-3;Q9Y2Q3;Q9 Y2Q3-2 H0YAR1;Q9Y 4K0 P38117;P O00299 Ribonuclease protein subunit p38 P 60S ribosomal protein L10 40S ribosomal protein S3 Glutathione S- transferase kappa 1 Lysyl oxidase homolog 2 Electron flavoprotein beta transfer subunit Chloride intracellular channel protein 1 RPP E RPL E RPS3 3.49E GSTK1 5.67E LOXL2 1.26E ETFB 6.89E CLIC1 1.71E EGVVECSFVK G3XAL0;P ;P40926 Malate dehydrogenase;malat e dehydrogenase, MDH2 3.22E TYAICGAIR VACIGAWHPA R LLLCGGAPLS ATTQR Q8WVC2;Q9 BYK1;P63220 G5E9G0;P39 023;B5MCW2 ;H7C422;Q O S ribosomal protein S21 60S ribosomal protein L3;60S ribosomal protein L3-like Long-chain-fatty-acid-- CoA ligase 3 RPS E RPL3;RPL3L 5.76E ACSL3 8.97E S200

201 AFGGPGAGCI SEGR SSGCDVNLP GVNVK YGVGTCGPR IVEDDASISSC NK IASHPILCR Q9H479 Q09666 O15269;O Q7Z5K2;Q7Z 5K2-2;Q7Z5K2-3 F8W9T3;O ;O95219 Fructosamine-3- kinase Neuroblast differentiationassociated protein AHNAK Serine palmitoyltransferase 1 Wings apart-like protein homolog FN3K 2.97E AHNAK 3.44E SPTLC1 5.08E WAPAL 1.20E Sorting nexin-4 SNX4 2.29E KTAGQTGMC GGVR Q5VTL8-2;Q5VTL8 Pre-mRNA-splicing factor 38B PRPF38B 2.29E TNAGTFSQ PEK SCSNAAFALK LIPDGCGVK QFLDFGSSNA CEK VCASGMK GMPHKCYHG K Oxidation (M); O43684;J3QS X4;J3QT28;O Q68CP9-3;Q68CP9 F8W7C6;A0A 087WV22;X1 WI28;P27635 Q15119 P24752;E9PK F3;H0YEL7;P G3V1B3;M0R 181;P46778 Mitotic checkpoint protein BUB3 AT-rich interactive domain-containing protein 2 60S ribosomal protein L10 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, Acetyl-CoA acetyltransferase, 60S ribosomal protein L21 BUB3 9.82E ARID2 4.84E RPL E PDK2 3.64E ACAT1 1.14E RPL E YSNSALGHVN CTIKELR H7C106;F8W 914;Q9NQC3-3;Q9NQC3-2;Q9NQC3-5;Q9NQC3-4;Q9NQC3-6;Q9NQC3 Reticulon;Reticulon-4 RTN4 4.40E NDTGTTIG PILASR SSGQSNNNS DTCAEFR AQEPLVDGCS GGGR E7EMB6;E7E TB3;Q9ULA0 C9IZZ8;C9J6 Y2;C9J0J6;C 9JZ07;G3V1A 3;C9J5T5;C9J BU8;A8MPU2 ;O ;O14713 E7ER77;Q7Z 2K6 Aspartyl aminopeptidase Integrin beta-1-binding protein 1 Endoplasmic reticulum metallopeptidase 1 DNPEP 3.17E ITGB1BP1 9.40E ERMP1 1.16E MLQGPPA DKPEEN KCTSGGYYR LCPNSTGAEI R Q9BWJ5 S4R3D6;Q96 GX9-3;Q96GX9 P ;P35998 Splicing factor 3B subunit 5 Methylthioribulose-1- phosphate dehydratase 26S protease regulatory subunit 7 SF3B5 1.89E APIP 1.26E PSMC2 1.11E AHTVLAASCA R NCNDFQYES K Q8WUY1 Protein THEM6 THEM6 5.82E A2IDB2;Q protein eta YWHAH 1.96E YAGGNPVCV RPTPK H0YKX3;Q15 004;H0YMA4 NA-associated factor KIAA E S201

202 LECLQR Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E9 PMV1 Plectin PLEC 1.28E RSGAELALDY LCR H7C0T1;H7C 2R9;C9JQV0; Q9BRJ6 Uncharacterized protein C7orf50 C7orf E SFFDNISCDD NRER A0A096LP11; Q8ND56-3;Q8ND56-2;Q8ND56 Protein homolog A LSM14 LSM14A 1.05E RVAYDK P46109 Crk-like protein CRKL 2.03E RRCDELTR J3QSF1;J3KT A4;P ;P17844 ATP- RNA Probable dependent helicase DDX5 DDX5 1.94E VRYSLDPENP TKSCK A0A087WY81 ;J3KRB3;A0A 087WWH0;J3 QS96;A0A087 WXM6;J3QQ T2;J3KRX5;P 18621;P ;J3KSJ0 60S ribosomal protein L17 RPL E NGYDYGQCR SCLLLQFTDK R S4R3G0;Q Q5HYI5;Q8W UD1;E9PE37; H0YDL5;H0Y D31;E9PKL7; P61019 Serine/arginine-rich splicing factor 9 Ras-related protein Rab-2B;Ras-related protein Rab-2A SRSF9 3.74E DKFZp313C1 541;RAB2B;R AB2A 4.34E TLLVNCQNK Q8TC07-2;Q8TC07;Q8 TC07-3;F8VV61;C9 JA93 TBC1 domain family member 15 TBC1D E LQEVECEEQ R H0YK42;Q ;Q13596;Q Sorting nexin-1 SNX1 4.27E SCPSFSASSE GTR D6RCP9;D6R FG8;P27707; D6RG38 Deoxycytidine kinase DCK 2.15E LLDRDACDTV R K7EN20;K7E L16;Q9NZL4-2;Q9NZL4;Q9 NZL4-3 Hsp70-binding protein 1 HSPBP1 3.61E SEFERLECLQ R Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E9 PMV1 Plectin PLEC 1.51E S202

203 PVCCLPTCSK AAFGLSEAGF NTACVTK DVQIGDIVTV GECRPLSK ASDHGWVCD QR NTGIICTIGPA SR GCLGNSKTE DQRNEEK VAGDCLDEK QCK P60370;P A0A087X1I3; D6RFM5;P ;P ;P31040 P62280;M0R1 H5 Q9HC36 B4DNK4;P14 618;H3BU13; H3BT25;H3B UW1;H3BTJ2; H3BQ34;H3B TN5;P Q5JWD1;A0A 0A0MR13;P ;P ;P63092;P Q96AG4 2 Carbamidomet hyl (C);IAAyne Keratin-associated protein 10-5;Keratinassociated protein 10-1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, 40S ribosomal protein S11 RNA methyltransferase-like protein 1 Pyruvate kinase;pyruvate kinase PKM Guanine nucleotidebinding protein G(s) subunit alpha isoforms short Carbamidomet hyl (C);IAAyne Leucine-rich repeatcontaining protein 59 KRTAP10-5;KRTAP E SDHA 1.31E RPS E RNMTL1 1.07E PKM 6.81E GNAS 1.09E LRRC E AEEDVEPECI MEK H0Y5J4;B4D DD6;Q9UJU6-5;Q9UJU6-4;Q9UJU6;Q9 UJU6-2;Q9UJU6-3 Drebrin-like protein DBNL 7.43E TTEEQVQAST PR YYEKR Q14137 P82921 Ribosome biogenesis protein BOP1 28S ribosomal protein S21, BOP1 7.46E MRPS E YLTCPK Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149 Plectin PLEC 3.89E EVILCKDQDG K LVGERYCK CLRDEHRCA SK Carbamidomet hyl (C);IAAyne G5EA09;O ;O ;O00560 P82673 H0YE57;Q9U BM7 Syntenin-1 SDCBP 8.65E S ribosomal protein S35, 7-dehydrocholesterol reductase MRPS E DHCR7 1.56E RTGCTFPEKP DFH AICIDPAYSK P ;P ;P ;P55263 K7EMD6;O Adenosine kinase ADK 1.61E Small glutamine-rich tetratricopeptide repeat-containing protein alpha SGTA 7.69E S203

204 TVGVQGDCR CLVDSAETK RQLCGGNQA ATER GTCADRDNLT RR LSNVAPILR RCQYVTEK EIDCLSPEAQ K P ;P49915 J3QRV5;Q6P 1M3-2;Q6P1M3 R4GMX8;Q6V N20-2;Q6VN20-3;Q6VN20 D6RHU3;P C9JB30;Q9U PY8-2;Q9UPY8 P04075;P ;J3KPS3;H3 BPS8;H3BQN 4;P09972 Q32MZ4-3;Q32MZ4-2;Q32MZ4;C9 JTC6 GMP synthase [glutaminehydrolyzing] Lethal(2) giant larvae protein homolog 2 GMPS 8.22E SPATS2;LLGL E Ran-binding protein 10 RANBP E Caspase-6;Caspase-6 subunit p18;caspase- 6 subunit p11 Microtubuleassociated protein RP/EB family member 3 Fructosebisphosphate aldolase A;Fructosebisphosphate aldolase C Leucine-rich repeat flightless-interacting protein 1 CASP6 2.20E MAPRE3 1.32E ALDOA;ALDO C 8.27E LRRFIP1 2.38E YMLDCR ATELFVQCLA TYSYR TQEQCVHNE TKNELEK Oxidation (M); Q9Y277;Q9Y Q9NRG0 E5KLK1;E5KL J6;E5KLJ9;E5 KLJ5;O60313; O Voltage-dependent anion-selective channel protein 3 Chromatin accessibility complex protein 1 Dynamin-like 120 kda protein, ;Dynami n-like 120 kda protein, form S1 VDAC3 4.29E CHRAC1 6.03E OPA1 1.33E WASGLTPAQ NCPR Q6P1N7;C9J A35;A2AB90; A0A0A0MSV9 ;O ;O15533;O Tapasin TAPBP 9.03E SLVQNNCLSR PNIFLCPEIEP K LQLECQR Carbamidomet hyl (C);IAAyne F8VXC8;Q8T AQ2-2;Q8TAQ2-3;Q8TAQ2 Q14151 SWI/SNF complex subunit SMARCC2 Scaffold factor B2 attachment SMARCC2 8.61E SAFB2 1.93E NCIVLIDSTPY R NGGGGGGG GSGLHCAGN GGGGGGGPR KRVPDHH ACFQVGTSEE MK LSNNYYCTR AVVVCPKDED YKQR VDCDQHSDIA QR Oxidation (M); P62241;Q5JR 95 H7C603;Q96L 92-3;Q96L92 P ;P78371 A0A0A0MSW 3;P ;P ;P35658;P ;P O95182 Q ;Q00839 Q9BS26 40S ribosomal protein S8 RPS8 1.85E Sorting nexin-27 SNX E T-complex protein 1 subunit beta Nuclear pore complex protein Nup214 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Heterogeneous nuclear ribonucleoprotein U Endoplasmic reticulum resident protein 44 CCT2 3.18E NUP E NDUFA7 3.92E HNRNPU 4.50E ERP E S204

205 YLAEVACGDD R E9PG15;P protein theta YWHAQ 4.91E VRPRPTCR H3BPD0;H3B P01;E7ERS3; Q86VM9-2;Q86VM9 Zinc finger CCCH domain-containing protein 18 ZC3H E KTTEEQVQAS TPR Q14137 Ribosome biogenesis protein BOP1 BOP1 1.18E CSVKNDHSAY KR A0A087WTQ 3;A0A087WW Z1;E7EVJ5;Q 96F07-2;Q7L576;Q9 6F07 Cytoplasmic FMR1- interacting protein 2;Cytoplasmic FMR1- interacting protein 1 CYFIP2;CYFI P1 1.63E GCLDEETSR Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149 Plectin PLEC 3.05E NFILDQCNVY NSGQR CTSHSETPTV DDEEKVDER H3BQZ7;Q1K MD3 O ;O ;O ;O95425 Heterogeneous nuclear ribonucleoprotein U- like protein 2 HNRNPUL2- BSCL2;HNRN PUL2 1.08E Supervillin SVIL 2.46E CAIEADMK NCFASVFEK Q9H0E9-3;H7C128;H7 C179;Q9H0E 9-4;B5MCW3;H 7C127;Q9H0 E9-2 O15144 Actin-related protein 2/3 complex subunit 2 BRD8 1.23E AR2 8.19E CGGIDEMQS SR VYAVATSTNT AR TCVLFR C9JRX0;C9K 0U4;C9J6Y6; A0A0A0MTF7 ;Q9UQR1 Q10570 P61026;P ;P61006 Zinc finger protein 148 ZNF E Cleavage and polyadenylation specificity factor subunit 1 Ras-related protein Rab-10;Ras-related protein Rab-8A CPSF1 3.45E RAB10;RAB8 A 3.61E SGDAAIVDMV PGKPMCVES FSDYPPLGR Oxidation (M); A0A087WVQ 9;P ;Q5VTE0;P Elongation factor 1- alpha 1;Putative elongation factor 1- alpha-like 3 EEF1A1;EEF1 A1P5 8.58E ACVGNAYHK QKQYNCLTQ R TQLAVCQQR Q9UKX7-2;Q9UKX7 Q9Y3A2 Q02790;H0YF G2 Nuclear pore complex protein Nup50 Probable U3 small nucleolar RNAassociated protein 11 Peptidyl-prolyl cistrans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed NUP E UTP11L 3.48E FKBP4 1.59E S205

206 ENQWCEEK E5RJR5;P S-phase kinaseassociated protein 1 SKP1 1.48E STFQAHLAPV VCPK SCGSSTPDEF PTDIPGTK FICTTSAIQNR EIDKCLSR J3KT25;Q9P2 X3-2;Q9P2X3 P41091;H7BZ U1 P ;P53396;K7 ESG8;P Q14344 Protein IMPACT IMPACT 2.40E Eukaryotic translation initiation factor 2 subunit 3 EIF2S3 7.05E ATP-citrate synthase ACLY 1.86E Guanine nucleotidebinding protein subunit alpha-13 GNA E STTTSDPPNI CK H7C5N8;E7E PN9;Q9Y520-2;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9 Y520-7 Protein PRRC2C PRRC2C 1.06E GCPIGTGGVL SSQIK E5RGX6;E5R JK3;E5RIF0;E 5RH29;Q96L B3-2;Q96LB3 Intraflagellar transport protein 74 homolog IFT E ATAVDPTCAR IICQGFTGK QKICYAK REIVHLQAGQ CGNQIGAK VQYPQSQAC K Q8IY26 P53597;H7C2 33 P ;P78527 P04350;P683 71;M0R0X0;M 0R2T4;M0QY 85;M0QY37; M0QX14;M0R 042;M0R2D3; M0QYM7 Q14204 Presqualene diphosphate phosphatase Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, DNA-dependent protein kinase catalytic subunit Tubulin beta-4a chain;tubulin beta-4b chain Cytoplasmic dynein 1 heavy chain 1 PPAPDC2 1.05E SUCLG1 5.22E PRKDC 5.13E TUBB4A;TUB B4B 1.01E DYNC1H1 4.53E CNNVLYIR QVLVAPGNAG TACSEK P62306 C9JZG2;C9J KQ7;C9JBJ1; C9JTV6;F8W D69;P ;P22102 Small nuclear ribonucleoprotein F Trifunctional purine biosynthetic protein adenosine- 3;Phosphoribosylamin e--glycine ligase;phosphoribosylf ormylglycinamidine cycloligase;phosphoribosyl glycinamide formyltransferase SNRPF 2.98E GART 0.00E GCGTVLLSGP RK F8VUA6;G3V 203;H0YHA7; J3QQ67;Q ;Q S ribosomal protein L18 RPL E LCTSATESEV AR GSCSTEVEKE TQEK MCPATQK P31930 O75348 Q9H307-2;Q9H307 Cytochrome b-c1 complex subunit 1, V-type proton ATPase subunit G 1 UQCRC1 9.09E ATP6V1G1 0.00E Pinin PNN 2.77E S206

207 GQVPSGATG SSTCPK F8VWL3 FGD4 8.13E DCPHISQR B4DEM9;Q9Y 2S7 Polymerase deltainteracting protein 2 POLDIP2 5.50E AADCISEPVN REPPSR P43304;F5GY K7;E7EM56 Glycerol-3-phosphate dehydrogenase, GPD2 7.62E VLVTTNVCAR I3L352;I3L0H 8;F6QDS0;H3 BQK0;Q9UM R2-3;Q9NUU7-2;Q9UMR2-2;Q9UMR2-4;Q9NUU7;Q 9UMR2 ATP-dependent RNA helicase DDX19B;ATPdependent RNA helicase DDX19A DDX19A;DDX 19B 5.66E GCGLR Carbamidomet hyl (C);IAAyne K7EPB7;K7E R96;O43396 Thioredoxin-like protein 1 TXNL1 1.70E LGGTCVNVG CVPK Carbamidomet hyl (C);IAAyne P ;P ;P ;P ;P00390;H0 YC68 Glutathione reductase, GSR 2.70E SVGGACVLVA DLNYCFSGM SDHR YVECSALTQK MCSMVK VGVDYEGGG CR E9PJD9;P467 76;E9PLX7 E9Y7;G8J LB6;P31943; H0YBG7;H0Y BD7;H0YB39; P55795 P60953 D6RB09;D6R G13;D6RAT0; P61247;D6RE D7;D6RAS7; H0Y8L7;E9PF I5 Q02809;Q S ribosomal protein L27a Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N- terminally processed;heterogene ous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed Cell division control protein 42 homolog 40S ribosomal protein S3a Procollagen-lysine,2- oxoglutarate 5- dioxygenase 1 RPL27A 4.01E HNRNPH1;HN RNPH2 8.18E CDC E RPS3A 8.47E PLOD1 1.30E NIDPKTPR K7EQ55;K7E K33;Q96EP5-2;Q96EP5 DAZ-associated protein 1 DAZAP1 5.35E TYAICGAIRR Q8WVC2;Q9 BYK1;P S ribosomal protein S21 RPS E ISICSSDKR CYRDEGSRP DR Q13547 Histone deacetylase 1 HDAC1 4.36E Q6PI48 Aspartate--tRNA ligase, DARS2 3.45E SPPVDCPRK DTK Q5VZK9-2;Q5VZK9 Leucine-rich repeatcontaining protein 16A LRRC16A 4.62E S207

208 NCPHIVVGTP GR LVVPASQCGS LIGKGGCK Carbamidomet hyl (C);IAAyne F6UJC5;F6W LT2;Q5STU3; Q13838;Q ;F6S4E6;A0 A0A0MT12;F 6TRA5 F8W0G4;F8V XH9;F8W1G6 ;H3BRU6;F8V ZX2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;H3BND9 Spliceosome RNA helicase DDX39B Poly(rC)-binding protein 2 DDX39B 2.12E BP2 3.80E VLRHEEFEEG CK SRCDQLEER SGVIVLGA GK AFDTAGNGY CR I3L3Q4;F6TL X2;Q9HC38-2;I3L1F4;Q9H C38-3 Q9UN81 P19447 P49327 Glyoxalase domaincontaining protein 4 LINE-1 retrotransposable element ORF1 protein TFIIH basal transcription factor complex helicase XPB subunit Fatty acid synthase;[acyl-carrierprotein] S- acetyltransferase;[acyl -carrier-protein] S- malonyltransferase;3- oxoacyl-[acyl-carrierprotein] synthase;3- oxoacyl-[acyl-carrierprotein] reductase;3- hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl- [acyl-carrier-protein] hydrolase GLOD4 3.79E L1RE1 1.12E ERCC3 1.27E FASN 6.82E TAVCDIPPR P04350;P683 71;Q5ST81;A 0A075B736;Q 5SQY0;I3L2F 9;Q5JP53;Q3 ZCM7;P0743 7;A6NNZ2;Q9 BVA1;Q13885 Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta-8 chain;tubulin beta chain;tubulin beta-8 chain-like protein LOC260334;Tubulin beta-2b chain;tubulin beta-2a chain TUBB4A;TUB B4B;TUBB;TU BB8;TUBB2B; TUBB2A 3.74E QDEKECLK P23771;P Trans-acting T-cellspecific transcription factor GATA-3 GATA3 2.31E SAGALEEGTS EGQLCGR H7BXQ8;C9J 5N7;Q8N2F6-3;Q8N2F6 Armadillo repeatcontaining protein 10 ARMC E IVADQLCAK H3BQF7;H3B MU1;H3BUI0; J3KR23;P ;P ;P53990;P ;P IST1 homolog IST1 8.22E S208

209 IVEVNGVCME GK GLLDVTCK RACYGVLR AAADGDRDC VLQK VRFACHSASL TVR O14745;O E5RJR5;P632 08;E7ERH2;F 8W8N3;P P23396;P ;E9PL09 Q96D53;Q96 D53-2 C9IZL7;C9JY S8;Q ;Q15233 Na(+)/H(+) regulatory NHE-RF1 exchange cofactor S-phase kinaseassociated protein 1 40S ribosomal protein S3 AarF domaincontaining protein kinase 4 Non-POU domaincontaining octamerbinding protein SLC9A3R1 3.92E SKP1 2.24E RPS3 9.55E ADCK4 6.16E NONO 1.92E LCMAGR KACQIFVR ALRPGDPGF CAR Q8TDG2 P ;P52272;A0 A087X0X3;M 0QY96;M0R2I 7 Q96ST2-2;Q96ST2-3;Q96ST2 Actin-related T1 protein Heterogeneous nuclear ribonucleoprotein M ACTRT1 3.02E HNRNPM 1.76E Protein IWS1 homolog IWS1 1.33E VVTQNICQYR A0A087X2B6; G3V119;H0Y B24;Q8N163-2;Q8N163 Cell cycle and apoptosis regulator protein 2 CCAR2 1.69E VAYQDPSSG CTSK YDDMAACMK YYDAIACLK LVTECEQKK NVGTGLVGAP ACGDVMK SKDGVCVR AVAILCNHQR YVENPSQVLN CER AACCLAGAR FTCTVNR SGANVLICGP NGCGK CQELALR E9PNR2;Q ;Q13671 E7EX29;P631 04;E5RGE1;E 5RIR4;E9PD2 4;E7EVZ2;E7 ESK7 V9GYQ3;E9P MH2;O00170 Q06546 F5H5N2;B4D NC9;B3KQ30; Q9H1K1-2;Q9H1K1 E9PLK3;P ;P55786 Ras and Rab interactor protein zeta/delta AH receptorinteracting protein GA-binding alpha chain protein Iron-sulfur cluster assembly enzyme ISCU, Puromycin-sensitive aminopeptidase RIN1 8.82E YWHAZ 4.00E AIP 3.72E GABPA 1.44E ISCU 3.51E NPEPPS 1.75E P11387 DNA topoisomerase 1 TOP1 0.00E E9PF10;O ;O75694 M0R0U3;M0R 261;O95336 O43747;O Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne P ;P28288 H0YCI3;P ;P ;P ;P46937;P Nuclear pore complex protein Nup phosphogluconolacton ase AP-1 complex subunit gamma-1 ATP-binding cassette sub-family D member 3 NUP E PGLS 3.79E AP1G1 8.04E ABCD3 3.09E Yorkie homolog YAP1 5.76E S209

210 GTCADRDNLT R SSKQHYNCE HSK D6RHU3;P55 212;D6RBM3 E9PQ34;E9PI G2;E9PRS3;E 9PNX1;E9PK 86;E9PMI5;E 9PR70;E9PP V6;P50454 Caspase-6;Caspase-6 subunit p18;caspase- 6 subunit p11 CASP6 3.63E Serpin H1 SERPINH1 2.21E YIEACARR O ;O60701;E7 ER83;E7ETF 4;E7EV97 UDP-glucose 6- dehydrogenase UGDH 4.55E KITIADCGQLE MSSYAFFVQT CR SYESSEDCSE AAGSPAR AGMAAVASPT GNCDLER Oxidation (M); Oxidation (M); P62937;P D6R9A6;Q5T 7C4;Q5T7C6; P26583;P094 29;B2RPK0 K7ER58;Q6P 6C2-3;Q6P6C2 Q6P1M0-2;Q6P1M0 Peptidyl-prolyl cistrans isomerase A;Peptidyl-prolyl cistrans isomerase A, N- terminally processed High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 RNA demethylase ALKBH5 Long-chain fatty acid transport protein 4 PPIA 9.37E HMGB2;HMG B1;HMGB1P1 1.70E ALKBH5 1.27E SLC27A4 3.25E IFVGNVSAAC TSQELR Q96PK6-5;F8WDX3;A0 A0A0MSL8;B 8ZZ74;Q96PK 6-3;Q96PK6-4;Q96PK6-2;Q96PK6 RNA-binding 14 protein RBM E MKLNISFPAT GCQK NMACVQR LTSENCEHFV NELR SPSSDSWTC ADTSTERR SDLYSSCDR Oxidation (M); P62753;A2A3 R7 X6RJP6;P378 02;P P53816 H0YIQ0;E5R HH7;F8VWH9 ;Q8N6T3-4;Q8N6T3-5;Q8N6T3;Q8 N6T3-2 Q96E39 40S ribosomal protein S6 RPS6 8.52E Transgelin-2 TAGLN2 1.34E HRAS-like suppressor 3 ADP-ribosylation factor GTPase-activating protein 1 RNA binding motif protein, X-linked-like-1 PLA2G E ARFGAP1 3.29E RBMXL1 5.68E VLELVSITANK NTCPGDR H0YIZ0;P ;P ;P34897 Serine hydroxymethyltransfer ase;serine hydroxymethyltransfer ase, SHMT2 1.54E ILEPHNGKCR B4DSN5;P Tyrosine-protein phosphatase nonreceptor type;tyrosineprotein phosphatase non-receptor type 1 PTPN1 2.13E VGTECGNQK VR A0A087WWY 3;Q5HY54;Q6 0FE5;P ;P21333 Filamin-A FLNA 7.88E S210

211 CTKEEHLCTQ R Carbamidomet hyl (C);IAAyne Q5VU61;A0A 087WWU8;Q 5VU59;P ;J3KN67;P ;P TPM3 2.39E SSTETCYSAI PK E7EN95;O ;O ;O ;O ;O ;O75369;O ;A0A0A0MT 44 Filamin-B FLNB 2.42E GCEVVVSGK P23396;P ;E9PL09;H0 YEU2;E9PJN 9;E9PSF4 40S ribosomal protein S3 RPS3 1.62E GAYRDCLGR Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E9 PMV1 Plectin PLEC 6.74E APPKVVLV ESSER YYTSASGDE MVSLKDYCTR MLSCAGADR KTGEGSKT WDR Oxidation (M); F5H1I5;F5GZ T7;P50336 P07900;P F8W7C6;A0A 087WV22;X1 WI28;P27635; B8A6G2;A6Q RI9;Q96L21;H 7C123;H7C2 C5 P60866;P ;G3XAN0 Protoporphyrinogen oxidase Heat shock protein HSP 90-alpha 60S ribosomal protein L10;60S ribosomal protein L10-like 40S ribosomal protein S20 PPOX 2.76E HSP90AA1 1.04E RPL10;RPL10 L 6.99E RPS E VPGEQGSDE EHCKEHR Q9UNS1-2;Q9UNS1 Protein homolog timeless TIMELESS 7.24E SQSEGLKGE HGCR Q6ZUK4 Transmembrane protein 26 TMEM E SGQGAFGNM CR P36578;H3BT P7;H3BU31 60S ribosomal protein L4 RPL4 0.00E SQDVAVSPQ QQQCSK H3BTD6;H3B Q37;H3BPW9 ;Q96F86 Enhancer of mrnadecapping protein 3 EDC3 0.00E SSPGNKDKE ASR H0Y704;O ;O ;O ;O15231;O ;O ;O ;H7BZT5;H7 C1R1 Zinc finger protein 185 ZNF E ALIVDESCRR Q6NYC8-4;Q6NYC8-3;Q6NYC8 Phostensin PPP1R E S211

212 SCEREESLRR A0A044PY82; Q96FF7 Uncharacterized protein LOC MIR E DKISDSNDQE SANCDAK H7C0C0;Q9Y 5Q9 General transcription factor 3C polypeptide 3 GTF3C3 4.77E CTPSVISFGS K GCPVNTEPS GPTCEKK Carbamidomet hyl (C);IAAyne Q ;Q ;Q92598;R4 GN69 P53701 Heat shock protein 105 kda Cytochrome heme lyase c-type HSPH1 4.49E HCCS 3.39E QFCSTQAALQ AMER A0A087WY61 ;Q ;Q ;Q ;Q14980 Nuclear mitotic apparatus protein 1 NUMA1 4.29E FFSDCK CGVISPR E9Y7;G8J LB6;P31943; D6RIT2;D6RF 17;D6RDL0;E 7EQJ0;D6RA M1;D6R9T0;D 6RFM3;E7EN 40;D6RIU0;D 6RDU3;D6RJ 04;D6RIH9;D 6RBM0;P I3L3P7;P Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N- terminally processed;heterogene ous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H2 40S ribosomal protein S15a HNRNPH1;HN RNPH2 3.07E RPS15A 1.93E INQMVCNSDR MREIVHLQAG QCGNQIGAK EAEEEEASCL LGPTLK AAGPLLTDEC R TSCKDDEAVV QAPR DSCPLDCK SGRYEAAFPF LSGR CVFELPAEND KPHDVEINK Oxidation (M); Carbamidomet hyl (C);IAAyne P06400 P04350;P683 71;M0R0X0;M 0R2T4;M0QY 85;M0QY37; M0QX14;M0R 042;M0R2D3; M0QYM7 H3BLU1;Q4K MQ1-2;Q4KMQ1-4;Q4KMQ1-3;Q4KMQ1 Q9BQ69 A0A0A0MSW 3;P ;P ;P35658;P ;P A0A087X2D0; P ;P84103 H0YF29;Q6P 1X6-2;Q6P1X6 O95292 Retinoblastomaassociated protein Tubulin beta-4a chain;tubulin beta-4b chain RB1 4.29E TUBB4A;TUB B4B 9.74E Taperin TPRN 1.91E O-acetyl-ADP-ribose deacetylase MACROD1 Nuclear pore complex protein Nup214 Serine/arginine-rich splicing factor 3 UPF0598 C8orf82 protein Vesicle-associated membrane proteinassociated protein B/C MACROD1 3.62E NUP E SRSF3 4.29E C8orf E VAPB 9.25E S212

213 YSLDPENPTK SCK SCYDLSCHAR GSCFHR KCTLDQAFR VWNLANCK ANSSVVSVNC K IVLVDDRECP VRR SYCAEIAHNV SSK SQAANKD EADLSSK RTDPECTAPI KK NYLSCDVEVR SKKPLMVIHH LEDCQYSQAL K GCITIIGGGDT ATCCAK RNCWPR A0A087WY81 ;J3KRB3;A0A 087WWH0;J3 QS96;A0A087 WXM6;J3QQ T2;J3KRX5;P 18621;P ;J3KSJ0 60S ribosomal protein L17 RPL E P41250 Glycine--tRNA ligase GARS 1.03E P62937;F8W E65;C9J5S7; A0A075B767; A0A075B759; Q9Y536;F5H2 84;A2BFH1 J3KRD7;J3Q QZ3;J3KT14; A0A087WY84 ;A0A087WWS 1;Q96FV9-2;Q96FV9 D6RBD0;D6R FX4;D6RHH4; D6R9Z1;H0Y AM7;J3KPE3; H0Y8W2;D6R 9L0;P63244;H 0Y8R5;D6RA C2;D6REE5 O ;O ;O ;O60502 O15067 D3YTB1;F8W 727;P62910 Q96SK2-3;Q96SK2-2;Q96SK2 Q5T7F5;Q8N 1G2 P43304;P H7C040;B5M C62;Q8TD06 Oxidation (M); 2 Carbamidomet hyl (C);IAAyne P ;P00558 E9PP36;E9P KZ0;E9PKU4; P62917 Carbamidomet hyl (C);IAAyne Peptidyl-prolyl cistrans isomerase A;Peptidyl-prolyl cistrans isomerase A, N- terminally processed;peptidylprolyl cis-trans isomerase;peptidylprolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A- like 4D;Peptidyl-prolyl cis-trans isomerase A- like 4G THO complex subunit 1 Guanine nucleotidebinding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2- like 1, N-terminally processed Bifunctional protein NCOAT;Protein O- GlcNAcase;Histone acetyltransferase Phosphoribosylformylg lycinamidine synthase 60S ribosomal protein L32 Transmembrane protein 209 Cap-specific mrna (nucleoside-2'-o-)- methyltransferase 1 Glycerol-3-phosphate dehydrogenase, Anterior gradient protein 3 homolog Phosphoglycerate kinase 1 60S ribosomal protein L8 PPIA;PPIAL4F ;PPIAL4A;PPI AL4D;PPIAL4 G 1.02E THOC1 4.36E GNB2L1 4.38E MGEA5 4.87E PFAS 1.37E RPL E TMEM E CMTR1 1.38E GPD2 1.90E AGR3 8.25E PGK1 2.50E RPL8 5.26E S213

214 CAQYWPQKE EK B4DSN5;P Tyrosine-protein phosphatase nonreceptor type;tyrosineprotein phosphatase non-receptor type 1 PTPN1 6.72E DFTPVCTTEL GR VTYDSDATSS ACR ATCAPQHGA PGPGPADAS K IAICGAISTYN R LIGPNCPGVIN PGECK VCETDGCSS EAK CRGGAGSGT GGGPGLGSR ERICSEEER IIPDCNADNSK Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne P30041 Peroxiredoxin-6 PRDX6 1.27E A0A087X0N2; O15243 A0A087WWY 3;Q5HY54;Q6 0FE5;P ;P21333 F2Z3J9;Q ;Q14914 P53597 P53582;H0Y9 L0;D6RF24 F8WFE0;Q8 WVR3 C9JRZ6;F8W AR4;Q9NX63 M0QYU7;M0 QXT0;B4DLJ 1;Q ;Q ;Q ;Q15853 Leptin receptor generelated protein LEPROT 9.88E Filamin-A FLNA 7.79E Prostaglandin reductase 1 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, Methionine aminopeptidase 1 Uncharacterized protein C7orf43 MICOS complex subunit MIC19 Upstream stimulatory factor 2 PTGR1 2.19E SUCLG1 6.16E METAP1 1.23E C7orf E CHCHD3 1.03E USF2 5.71E NRKHPSSPE CLVSAQK A0A087WY61 ;Q ;Q ;Q ;Q14980;F5 H6Y5;F5H4J1 ;Q ;F5H0Z7;F5 H763;F8W6T 3;F5H1L0;F5 GZW1;F5H2F 3;F5H3L6 Nuclear mitotic apparatus protein 1 NUMA1 5.82E NQLKETTEAA CR ENQEQGD VIQIK SWCGACK E9PFN5;Q9Y 2Q3-4;Q9Y2Q3-3;Q9Y2Q3;Q9 Y2Q3-2 H0Y3X6;Q9H 3P2-7;Q9H3P2 O95881 Glutathione S- transferase kappa 1 Negative factor A elongation Carbamidomet hyl (C);IAAyne Thioredoxin domaincontaining protein 12 GSTK1 5.78E NELFA 1.60E TXNDC E S214

215 NMMAACDPR Oxidation (M); P04350;P683 71;Q5ST81;A 0A075B736;Q 5SQY0;I3L2F 9;Q5JP53;Q3 ZCM7;P0743 7;A6NNZ2;Q9 BVA1;Q13885 ;K7ESM5;Q ;Q9BUF5;Q Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta-8 chain;tubulin beta chain;tubulin beta-8 chain-like protein LOC260334;Tubulin beta-2b chain;tubulin beta-2a chain;tubulin beta-3 chain;tubulin beta-6 chain TUBB4A;TUB B4B;TUBB;TU BB8;TUBB2B; TUBB2A;TUB B6;TUBB3 1.01E ACQIFVR P ;P52272;A0 A087X0X3;M 0QY96;M0R2I 7 Heterogeneous nuclear ribonucleoprotein M HNRNPM 2.28E QCEGITSPEG SK Q9Y570-2;Q9Y570;Q9 Y570-4 Protein phosphatase methylesterase 1 PPME1 4.82E AGGPPQVAG AQAACSEDR D6RBJ6;B3K VZ3;Q9H3R5 Centromere protein H CENPH 2.57E SISIPGQDSSL QLTCK Q5T9C2-3;Q5T9C2-2;Q5T9C2 Protein FAM102A FAM102A 1.66E YLNRGCTR SQGGEEEGP LSDKCSRK TPKDKEEIVIC DR ACFQVGTSEE MK SGEQCSVEP DLISK A0A0A0MRM 8;E7EW20;Q9 UM54-5;Q9UM54-2;Q9UM54-6;Q9UM54-4;Q9UM54-1;Q9UM54 E9PR76;E9P SH4;Q9H063 Q9NRR5-2;Q9NRR5 A0A0A0MSW 3;P ;P ;P35658;P ;P Q8N201 Unconventional myosin-vi Repressor of RNA polymerase III transcription MAF1 homolog MYO6 3.24E MAF1 1.55E Ubiquilin-4 UBQLN4 1.83E Nuclear pore complex protein Nup214 Integrator subunit 1 complex NUP E INTS1 4.25E SLLINAVEASC IR J3QKT4;E2Q RB3;P ;P32322;P ;A0A087WT V6;A0A087W ZR9;J3KR12; Q96C36 Pyrroline-5- carboxylate reductase;pyrroline-5- carboxylate reductase 1, ;Pyrrolin e-5-carboxylate reductase 2 PYCR1;PYCR E STSTSEPTTG CSLK AIACQLSR YTQSNSVCYA K Q8ND82 Q5T160 H7C084;H7C 1S2;P ;P31939 Zinc finger protein 280C Probable arginine-- trna ligase, Bifunctional purine biosynthesis protein PURH;Phosphoribosyl aminoimidazolecarbox amide formyltransferase;imp cyclohydrolase ZNF280C 6.90E RARS2 7.11E ATIC 2.88E S215

216 ALANSLACQG K P04075;P ;J3KPS3;H3 BR68 Fructosebisphosphate aldolase A ALDOA 1.87E NMMAACDPR P04350;P683 71;Q5ST81;A 0A075B736;Q 5SQY0;I3L2F 9;Q5JP53;Q3 ZCM7;P0743 7;A6NNZ2;Q9 BVA1;Q13885 ;K7ESM5;Q ;Q9BUF5;Q Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta-8 chain;tubulin beta chain;tubulin beta-8 chain-like protein LOC260334;Tubulin beta-2b chain;tubulin beta-2a chain;tubulin beta-3 chain;tubulin beta-6 chain TUBB4A;TUB B4B;TUBB;TU BB8;TUBB2B; TUBB2A;TUB B6;TUBB3 1.98E IINDNATYCR O00567;Q5JX T2 Nucleolar protein 56 NOP E YVDIAINNK C9J9K3;A6N E09;P S ribosomal protein SA RPSA;RPSAP E FGEVVDCTIK TDPVTGR A0A087WUK 2;O ;O ;O14979 Heterogeneous nuclear ribonucleoprotein D- like HNRNPDL 2.35E GKYDCGHVQ KK O S ribosomal protein S12, MRPS E LLGGFQETCS K SIPICTLK CATITPDEAR SWVCRK SEVLAEESIV CLQK SKGCGVVKF ESPEVAER Q9BVP2-2;Q9BVP2 P ;P22314 P ;P48735 F2Z3C0;A8M XK4;B5MCT8; C9JM19;P O ;O ;O ;O43663;H0 YLA0;H0YM4 2 P ;P52272;A0 A087X0X3 Guanine nucleotidebinding protein-like 3 Ubiquitin-like modifieractivating enzyme 1 Isocitrate dehydrogenase [NADP], 40S ribosomal protein S9 Protein regulator of cytokinesis 1 Heterogeneous nuclear ribonucleoprotein M GNL3 3.24E UBA1 3.44E IDH2 4.14E RPS9 1.55E PRC1 1.17E HNRNPM 1.21E VFCPEKAEEG PR H0Y613;Q ;Q ;Q14687 Genetic element 1 suppressor GSE1 6.00E GQKLCEIER D6RDA2;D6R 9L5;P ;P35659 Protein DEK DEK 1.80E SCVPSSFAQE ESAR VAVTEGCQPS R Q5T0W9 Protein FAM83B FAM83B 5.40E E7EN95;O ;O ;O ;O ;O ;O75369;O ;O ;O Filamin-B FLNB 2.32E S216

217 LGMLSPEGTC K VIVCNTK CNEQPNRVEI YEK SAVDLSCSRR CSCSFR ACFHCETCK KVFANPEDCV AFGK IMKDLDQCR Oxidation (M); Carbamidomet hyl (C);IAAyne 2 Carbamidomet hyl (C);IAAyne P49327 G3V3R6;P A0A087WTQ 3;A0A087WW Z1;E7EVJ5;Q 96F07-2;Q7L576;Q9 6F07;A0A087 WU52;A0A08 7WWL1;A0A0 87WVE1;H7C 229 Q9Y446;Q9Y 446-2;E9PK71 H3BV85;H3B TW0;H3BVE0 ;Q9H3K6-2;Q9H3K6 F6S2S5;Q148 47;Q ;K7ESD6 F5H7F6;F5H6 X2;P ;P10620 Fatty acid synthase;[acyl-carrierprotein] S- acetyltransferase;[acyl -carrier-protein] S- malonyltransferase;3- oxoacyl-[acyl-carrierprotein] synthase;3- oxoacyl-[acyl-carrierprotein] reductase;3- hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl- [acyl-carrier-protein] hydrolase FASN 4.94E Galectin;Galectin-3 LGALS3 2.05E Cytoplasmic FMR1- interacting protein 2;Cytoplasmic FMR1- interacting protein 1 CYFIP2;CYFI P1 3.58E Plakophilin-3 PKP3 1.43E BolA-like protein 2 LIM and SH3 domain protein 1 Microsomal glutathione S- transferase 1 BOLA2B;BOL A2 8.95E LASP1 3.73E MGST1 1.57E P60903 Protein S100-A10 S100A E EGLASATKDC SHREEK A0A087X055; Q ;Q ;Q ;Q92766;Q Ras-responsive element-binding protein 1 RREB1 3.68E GADQKPTSA DCAVR M0R3F6;M0R 2Z9;Q8IX01-4;Q8IX01-3;Q8IX01 SURP and G-patch domain-containing protein 2 SUGP2 9.23E KVEEVTKVCE GR SGQGAFGNM CR LQAFSAAIES CNK TIIGQQGDQS CANK Oxidation (M); M0QXN5;P P36578;H3BT P7;H3BU31 Q02790 Peptidyl-prolyl cistrans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed P ;P35251 Nuclear glycoprotein p62 pore 60S ribosomal protein L4 Replication factor C subunit 1 NUP E RPL4 4.69E FKBP4 0.00E RFC1 9.58E S217

218 NQCTQVVQE R YCDPDSYHR R KQCVDHYNE VK DICACAATGT GK GKLVDCK NCPHVVVGT PGR P ;P15924;P K7ENG2;P ;P26368 A0A087WXC 5;E7ESZ7;O A0A087X059; B7Z6D5;Q96 GQ7 Desmoplakin DSP 2.78E Splicing factor U2AF 65 kda subunit NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, Carbamidomet hyl (C);IAAyne Probable ATPdependent RNA helicase DDX27 U2AF2 1.05E NDUFA E DDX E P35270 Sepiapterin reductase SPR 3.01E K7EQN7;B1Q 2N1;O ;O00148;K7 EPJ3 ATP-dependent RNA helicase DDX39A DDX39A;DDX E EADEGCKKPL ER Q9NQG5 Regulation of nuclear pre-mrna domaincontaining protein 1B RPRD1B 6.92E IHMGSCAENT AK P24752 Acetyl-CoA acetyltransferase, ACAT1 3.00E DLDQCRDGK P60903 Protein S100-A10 S100A E EKQEEEEAKC LEK Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2.67E TVCDAAEKGV R K7ER39;K7E L96;O ;O ;O60664 Perilipin-3 PLIN3 1.26E VKQRLECEK ATVCEAAALE K MLPDKDCR LLLGNKCDME AK P ;P15924;P E9PJS3;Q9N UE0-2;Q9NUE0 G3V1A4;E9P P50;E9PK25; P23528;E9PL J3;E9PS23;E 9PQB7 A0A087WWB 9;P51153 Desmoplakin DSP 6.51E Palmitoyltransferase;P almitoyltransferase ZDHHC18 ZDHHC E Cofilin-1 CFL1 5.15E Ras-related Rab-13 protein RAB E TVFAEHISDE CKRR G5E9G0;P39 023;B5MCW2 ;H7C422;F8W CR1;H7C3M2 60S ribosomal protein L3 RPL3 2.19E IPISNWK G3V5R3;G3V 4X8;G3V3A4; Q13573 SNW domaincontaining protein 1 SNW1 9.14E S218

219 RACAAGTPAV IR ASGKESSGLV LLSSCPQTAS R AINCATSGVV GLVNCLR AGPGSLELCG LPSQK IAAYLQSDQF CK SQPVTTSESK DGDSCR A6NEM2;P ;P51610;P C9JM75;H7C 454;H7C1H7; Q6P087-2;Q6P087 P49327 Q ;Q14684 P21266 Q ;Q92576 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N- terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N- terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C- terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C- terminal chain 6 RNA pseudouridylate synthase domaincontaining protein 3 Carbamidomet hyl (C);IAAyne Fatty acid synthase;[acyl-carrierprotein] S- acetyltransferase;[acyl -carrier-protein] S- malonyltransferase;3- oxoacyl-[acyl-carrierprotein] synthase;3- oxoacyl-[acyl-carrierprotein] reductase;3- hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl- [acyl-carrier-protein] hydrolase Ribosomal RNA processing protein 1 homolog B Glutathione S- transferase Mu 3 HCFC1 4.06E RPUSD3 1.27E FASN 7.86E RRP1B 4.60E GSTM3 3.30E PHD finger protein 3 PHF3 1.54E YVVAVGLECG K Q6IA86-7;Q6IA86-2;Q6IA86-3;Q6IA86-5;Q6IA86;Q6I A86-6 Elongator protein 2 complex ELP2 6.40E ESSGLVLLSS CPQTASR IECSHIR GVVTCMR Q15024 C9JM75;H7C 454;H7C1H7; Q6P087-2;Q6P087 D6RC60;D6RI C3;Q6PIM0;A 0A087X2G6; Q9Y3C1;Q9Y 3C1-2 RNA pseudouridylate synthase domaincontaining RPUSD3 1.52E protein 3 Nucleolar protein 16 NOP E Exosome complex component RRP42 EXOSC7 3.43E VIVVGNPANT NCLTASK C9JRL4;B9A0 41;C9JF79;P ;P40925;P Malate dehydrogenase;malat e dehydrogenase, cytoplasmic MDH1 2.96E MEKDREICR Q8WVV4;Q8 WVV4-1 Protein POF1B POF1B 6.32E S219

220 LYDLVAGSNC LK P43304;F5GY K7;P Glycerol-3-phosphate dehydrogenase, GPD2 3.23E CQSLTEDLEF RK ATEGMVVADK NCSK SVSCSDEDEK PR CALRDAR Oxidation (M); E9PBF6;P Q99436;Q5T BG5;Q E9PMC9;Q7Z 589-2;Q7Z589-6;Q7Z589;Q7 Z589-5;Q7Z589-4;Q7Z589-7 A0A075B730; A0A087X1U6; P58107 Lamin-B1 LMNB1 9.74E Proteasome subunit beta type- 7;Proteasome subunit beta type Protein EMSY PSMB7 2.02E C11orf30;EMS Y 3.20E Epiplakin EPPK1 4.66E IDNKCSTGYE K P ;P49790;P Nuclear pore complex protein Nup153 NUP E QSACNLEKK P35579;P Myosin-9 MYH9 1.01E VFEAEQFGCP QR Q8NFG4-2;Q8NFG4 Folliculin FLCN 1.33E TKIKADPDGP EAQAEACSG ER J3QSY4;D6R C52;D6RCB9; Q9NX24 H/ACA ribonucleoprotein complex subunit 2 NHP2 2.08E FINYVKNCFR P ;P06748 Nucleophosmin NPM1 3.65E VDVAVNCAGI AVASK Q ;Q99714;Q5 H928 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B E LCDFNPK C9J8P9;P ;P ;P ;P ;P09496 Clathrin light chain A CLTA 2.05E TICAILENYQT EK CLIATGGTPR DLDQCR ALLDSSENCD R RLECLKEDVQ R CTDDFNGAQ CK YSQICAK DLAACIK Carbamidomet hyl (C);IAAyne Q5T5C7;P O ;O ;O ;O95831 Serine--tRNA cytoplasmic ligase, Apoptosis-inducing factor 1, SARS 8.18E AIFM1 7.64E P60903 Protein S100-A10 S100A E Q5VT52-2;Q5VT52-3;Q5VT52;Q5 VT52-5 Q99459 E9PM69;R4G NH3;P17980 Q5VTU8;P O75874 Regulation of nuclear pre-mrna domaincontaining protein 2 Cell division cycle 5- like protein 26S protease regulatory subunit 6A ATP synthase subunit epsilon-like protein, ;ATP synthase subunit epsilon, Isocitrate dehydrogenase [NADP] cytoplasmic RPRD2 3.64E CDC5L 1.95E PSMC3 1.49E ATP5EP2;ATP 5E 1.60E IDH1 1.91E S220

221 ICSWNVDGLR APQCLGK ASGSTLNSGS GNCPR CGSSEDLHD SVR CESAFLSKR TDFQQGCAK RTGCIGAK LLVGNKCDLT TKK ELCHTQSSHA SLR FGEVVDCTLK G3V5D9;H7C 4A8;G3V5M0; G3V359;G3V 3C7;G3V5Q1; G3V3M6;P Q ;Q00839 Q96JK2-2;Q96JK2-3;Q96JK2 Q7Z4V5;Q7Z 4V5-3 C9JXB8;C9J NW5;P83731 M0QXB5;O Q5VVC8;P ;P62913 E7END7;P ;P62820 F8W7S5;A0A 087WVV2;A0 A0A0MRV0;Q 9P2E9-3;Q9P2E9-2;Q9P2E9 D6RD83;D6R F44;D6RBQ9; H0YA96;D6R AF8;H0Y8G5; Q ;Q ;Q ;Q14103 DNA-(apurinic or apyrimidinic site) lyase;dna-(apurinic or apyrimidinic site) lyase, Heterogeneous nuclear ribonucleoprotein U DDB1- and CUL4- associated factor 5 Hepatoma-derived growth factor-related protein 2 60S ribosomal protein L24 Persulfide dioxygenase ETHE1, 60S ribosomal protein L11 Ras-related Rab-1A Ribosome-binding protein 1 protein Heterogeneous nuclear ribonucleoprotein D0 APEX1 2.23E HNRNPU 2.28E DCAF5 4.60E HDGFRP2 1.45E RPL E ETHE1 1.16E RPL E RAB1A 3.58E RRBP1 3.37E HNRNPD 1.09E YLAEVACGDD RK E9PG15;P protein theta YWHAQ 5.55E SIPLECPLSSP K CLSAAEEK TATAVAHCKR DLQPFPTCQA LVYR I3L2A2;I3L2N 7;Q ;Q92667 Q5VU61;A0A 087WWU8;Q 5VU59;P ;J3KN67;P ;P M0R210;P622 49;M0R3H0;Q 6IPX4;M0R1 M5 Q14137;Q A-kinase anchor protein 1, 40S ribosomal protein S16 Ribosome biogenesis protein BOP1 AKAP1 9.41E TPM3 1.29E RPS E BOP1 4.28E GKPHCSRNP VLVR F8VZA3;F8V WR1;F8VU16 ;F8VZ45;U3K QR5;Q S ribosomal protein L6 RPL6 7.98E SLSGSSPK SAGGSGGAG GGEQNGQEE KWCEK Q9UQ35-2;Q9UQ35;I3 L182;I3L4D8 K7ESI8;K7EL 92;K7ERC7;K 7EJX0;B7Z5N 5;Q ;Q15796 Serine/arginine repetitive matrix protein 2 Mothers against decapentaplegic homolog 2 SRRM2 4.70E SMAD2 7.31E S221

222 VAQLCDFNPK D6RJD1;P ;P09497 Clathrin light chain B CLTB 5.47E EQCCYNCGK PGHLAR 2 Carbamidomet hyl (C);IAAyne P ;P ;P ;P ;P ;P62633;P ;P Cellular nucleic acidbinding protein CNBP 1.61E DKMCSMVK GLPWSCSAD EVQR D6RB09;D6R G13;D6RAT0; P61247;D6RE D7;D6RAS7; H0Y8L7;E9PF I5 E9Y7;G8J LB6;P31943; D6RIT2;D6RF 17;D6RDL0;E 7EQJ0;D6RA M1;D6R9T0;D 6RFM3;E7EN 40;D6RIU0;D 6RDU3;D6RJ 04;D6RIH9;D 6RBM0;D6R9 D3;E5RGV0 40S ribosomal protein S3a Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N- terminally processed RPS3A 6.58E HNRNPH1 1.65E YRNPVSQCM R K7EJ99;A0A0 A0MSV7;K7E JM5;A0A087 WX29;K7EN9 4;B1AKP7;G3 V162;A0A087 X260;A0A087 WYY0;Q TAR DNA-binding protein 43 TARDBP 1.71E ASNPVIAAQL CSK Q9H329-2;Q9H329 Band 4.1-like protein 4B EPB41L4B 5.69E GLEAICAK Q3LIE7;Q ;Q15392 Delta(24)-sterol reductase Nbla03646;DH CR E SLRECELYVQ K P10644;K7EP R5;K7EQK3;K 7EMU2;X6RA V4;K7EMZ6;K 7EIE5;K7EID 3;K7EJ40;K7 EK41;K7EPB 2;P camp-dependent protein kinase type I- alpha regulatory subunit;campdependent protein kinase type I-alpha regulatory subunit, N- terminally processed PRKAR1A 6.26E TIAQK H0YBG6;P Stress-70 protein, HSPA9 6.23E SVSSNVES R Q9UQ35-2;Q9UQ35;I3 L182;I3L4D8 Serine/arginine repetitive protein 2 matrix SRRM2 3.32E QSVELCKK A0A087WVQ 6;Q ;Q00610;J3K RF5;K7EJJ5;J 3KS13 Clathrin heavy chain 1 CLTC 1.66E TATAVAHCK M0R210;P622 49;M0R3H0;Q 6IPX4;M0R1 M5 40S ribosomal protein S16 RPS E S222

223 IIPGFMCQGG DFTR LALEQQQLIC K ERDEENQEM SSCK ELVLDNCK SEICTEEPQK QK MLSCAGADR DLSHIGDAVVI SCAK NCSSFLIKR GMPHKCYHG K VIECSYTSAD GQR SEGFDTYRC DR Oxidation (M); P62937;F8W E65;C9J5S7; A0A075B767; A0A075B759; Q9Y536;F5H2 84 J3QK89;Q8I WX8 Peptidyl-prolyl cistrans isomerase A;Peptidyl-prolyl cistrans isomerase A, N- terminally processed;peptidylprolyl cis-trans isomerase;peptidylprolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A- like 4D Calcium homeostasis endoplasmic reticulum protein PPIA;PPIAL4F ;PPIAL4A;PPI AL4D 5.20E CHERP 1.04E O60934 Nibrin NBN 9.71E Q ;Q92688 Q8NFC6 F8W7C6;A0A 087WV22;X1 WI28;P27635; B8A6G2;A6Q RI9;Q96L21;H 7C123;H7C2 C5 P12004 H0YLP6;H0Y MF4;H0YKD8 ;P ;P ;P46779;P ;P G3V1B3;M0R 181;P46778 H0YE57;Q9U BM7 P12004 Acidic leucine-rich nuclear phosphoprotein 32 family member B Biorientation of chromosomes in cell division protein 1-like 1 60S ribosomal protein L10;60S ribosomal protein L10-like Proliferating nuclear antigen cell 60S ribosomal protein L28 60S ribosomal protein L21 7-dehydrocholesterol reductase Proliferating nuclear antigen cell ANP32B 1.14E BOD1L1 1.26E RPL10;RPL10 L 1.29E NA 1.84E RPL E RPL E DHCR7 5.13E NA 1.36E KHPSSPECLV SAQK A0A087WY61 ;Q ;Q ;Q ;Q14980;F5 H6Y5;F5H4J1 ;Q ;F5H0Z7;F5 H763;F8W6T 3;F5H1L0;F5 GZW1;F5H2F 3;F5H3L6 Nuclear mitotic apparatus protein 1 NUMA1 2.40E AVTNHSVYCS TK AGDELAYNSS SACASSR YLEKEEKCLP PPSIR J3QS45;J3KR Z4;J3KSZ5;J3 QL34;J3KS22 ;J3QS36;Q7Z 4W1 Q86Y37;Q86 Y37-4 O15269 L-xylulose reductase DCXR 5.94E CDK2-associated and cullin domaincontaining protein 1 Serine palmitoyltransferase 1 CACUL1 1.10E SPTLC1 9.05E S223

224 SAEVCKQDS PFSR I3L2A2;I3L2N 7;Q ;Q92667 A-kinase anchor protein 1, AKAP1 7.16E AGVVIHCNHR Q9H8P0 Polyprenol reductase SRD5A3 3.44E CLPTPK M0R117;Q S ribosomal protein L18a RPL18A 8.82E ECTIEATA P ;P ;P ;P ;P ;P62633;P ;P Cellular nucleic acidbinding protein CNBP 1.90E CPGESLINPG FK AALQEELQLC K KCEQSTSATL GVR EALNSCNKR CYIASAGADA LAK Q9BUH6 P49327 C9JNA8;Q ;Q92551 H7BY16;P O ;O43815 Uncharacterized protein C9orf142 Fatty acid synthase;[acyl-carrierprotein] S- acetyltransferase;[acyl -carrier-protein] S- malonyltransferase;3- oxoacyl-[acyl-carrierprotein] synthase;3- oxoacyl-[acyl-carrierprotein] reductase;3- hydroxyacyl-[acylcarrier-protein] dehydratase;enoyl- [acyl-carrier-protein] reductase;oleoyl- [acyl-carrier-protein] hydrolase Inositol hexakisphosphate kinase 1 C9orf E FASN 2.04E IP6K1 2.21E Nucleolin NCL 2.86E Striatin STRN 5.72E LCDLERER Q8IVT2 Mitotic interactor and substrate of PLK1 MISP 5.83E QCVPFRR A0A087WY81 ;J3KRB3;A0A 087WWH0;J3 QS96;A0A087 WXM6;J3QQ T2;J3KRX5;P 18621;P ;J3QLC8;A0 A0A0MRF8;P S ribosomal protein L17 RPL E CILQDGR GDFCIQVGR J3KRY3;S4R 3P3;J3QLE5; A8MT02;P ;P63162;P14 678;P ;P Q32Q12;O60 361;P22392;P ;E7ERL0;J3 KPD9;P15531 ;P Small nuclear ribonucleoproteinassociated proteins B and B';Small nuclear ribonucleoproteinassociated protein N Nucleoside diphosphate kinase;putative nucleoside diphosphate kinase;nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A SNRPN;SNRP B NME1- NME2;NME2P 1;NME2;NME E E S224

225 CPFVENTWK GGCPGGEAT LSQPPPRGG TR CDVDIRK HELQANCYEE VKDR CMALSTAVLV GEAKK FENLCK Oxidation (M); Q5JPI3-2;Q5JPI3 P20290 P63261;P607 09;Q562R1 G3V1A4;E9P P50;E9PK25; P23528 G3V4Z4;Q ;Q02252 Q58FF8;P082 38;Q58FG0;Q 58FF7;P0790 0;P Uncharacterized protein C3orf38 Transcription BTF3 factor Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;actin, cytoplasmic 1;Actin, cytoplasmic 1, N- terminally processed;beta-actinlike protein 2 C3orf E BTF3 3.93E ACTG1;ACTB; ACTBL2 1.38E Cofilin-1 CFL1 1.66E Methylmalonatesemialdehyde dehydrogenase [acylating], Putative heat shock protein HSP 90-beta 2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta- 3;Heat shock protein HSP 90-alpha ALDH6A1 1.73E HSP90AB2P; HSP90AB1;H SP90AA5P;H SP90AB3P;H SP90AA1 1.41E CPKPLKNR F5H0V7;H0Y H17;H0YGA9; H0YFF3;F5H 8G1;F5GY11; F5H1Z6;F5H8 H3;A0A087W XR2;Q9Y365 TP-like protein STARD E SIDCIR ACNLTDTQKE VK P13010 Q7LBC6-2;Q7LBC6;Q7 LBC6-3 X-ray repair crosscomplementing protein 5 Lysine-specific demethylase 3B XRCC5 2.58E KDM3B 6.36E VTFQPPSSIG CR A0MZ66-7;A0MZ66-5;A0MZ66-6;A0MZ66;A0 MZ66-3 Shootin-1 KIAA E KPLMVIHHLE DCQYSQALK K TACAINK DLLVQQASQC LSK TCATDLQTK SKKPLMVIHH LEDCQYSQAL K H7C040;B5M C62;Q8TD06 Q52LJ0;Q52L J0-2;E9PH82;Q8 NCA5-2;Q8NCA5 H3BQZ7;Q1K MD3 F8VVW8;F8V ZG4;F8W1J0; A6NF51;O ;O95861;O H7C040;B5M C62;Q8TD06 Anterior gradient protein 3 homolog Protein FAM98B;Protein FAM98A Heterogeneous nuclear ribonucleoprotein U- like protein 2 3'(2'),5'-bisphosphate nucleotidase 1 Anterior gradient protein 3 homolog AGR3 1.11E FAM98B;FAM 98A HNRNPUL2- BSCL2;HNRN PUL2 1.79E E BPNT1 6.90E AGR3 5.25E S225

226 AGCALSAESS R CCSGAIIVLTK CAAQTLEKR CDVDIR DFGIQPVEDK GACR SCAHDWVYE IHEGCEEPAT HNALAK Carbamidomet hyl (C);IAAyne K7ESB7;Q96 HP0 B4DNK4;P14 618;P E9PQ61;O P63261;P607 09;Q562R1 Q96GX2 Q32Q12;O60 361;P22392;P A0A087WVQ 6;Q ;Q00610 Dedicator of cytokinesis protein 6 Pyruvate kinase;pyruvate kinase PKM Zinc finger CCCH domain-containing protein 11A Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;actin, cytoplasmic 1;Actin, cytoplasmic 1, N- terminally processed;beta-actinlike protein 2 Putative ataxin-7-like protein 3B Nucleoside diphosphate kinase;putative nucleoside diphosphate kinase;nucleoside diphosphate kinase B DOCK6 4.80E PKM 1.19E ZC3H11A 4.87E ACTG1;ACTB; ACTBL2 7.82E ATXN7L3B 4.34E NME1- NME2;NME2P 1;NME2 2.42E Clathrin heavy chain 1 CLTC 7.65E QILIACSPVSS VR E9PRB3;J3K P30;Q5QJE6 Deoxynucleotidyltransf erase terminalinteracting protein 2 DNTTIP2 6.64E NKQPFSCR A0A0A0MTI6; Q9NYP7;Q9N YP7-2 Elongation of very long chain fatty acids protein 5 ELOVL5 2.15E TVTCPMSGK PLR HATAEEVEEE ERDRIPGPVC K CLSETHGERE K CANVNNSSTT SQR DSLTEKECVK EK CAAVDVEPPS K Carbamidomet hyl (C);IAAyne M0R3B2;A0A 075B6F9;Q9Y 314 Q8TDN6 O00257;O R4GNB2;R4G N35 P26358;P ;K7EMU8;K7 EJL0 F8VV04;Q ;Q15020 Nitric oxide synthaseinteracting protein Ribosome biogenesis protein BRX1 homolog E3 SUMO-protein ligase CBX4 DNA (cytosine-5)- methyltransferase 1 Squamous cell carcinoma antigen recognized by T-cells 3 NOSIP 7.37E BRIX1 2.54E CBX4 4.95E DENND4C 6.49E DNMT1 3.10E SART3 4.66E MVKQPSE SDIITEEDKSK O ;O ;O and SFRS1- interacting protein PSIP1 2.07E AQLSGLQLQP CLYK AEYLCR E9PPP6;O Q15008;C9J7 B7;C9J0E9;Q ;Q ;Q Ribosomal RNAprocessing protein 8 26S proteasome non- ATPase regulatory subunit 6 RRP8 1.57E PSMD6 1.87E AHVVFDAS K A0A087WWY 3;Q5HY54;Q6 0FE5;P ;P21333 Filamin-A FLNA 4.73E S226

227 CSKEVATAIR H0YEN5;P15 880;I3L404;E 9PM36;E9PM M9;E9PPT0 40S ribosomal protein S2 RPS2 1.60E SLASAQCPFL GPPR CTSGGYYR MLPDKDCR Oxidation (M); O43791 S4R3D6;Q96 GX9-3;Q96GX9 G3V1A4;E9P P50;E9PK25; P23528;E9PL J3;E9PS23;E 9PQB7 Speckle-type POZ protein Methylthioribulose-1- phosphate dehydratase SPOP 1.46E APIP 3.37E Cofilin-1 CFL1 1.07E LVVPASQCGS LIGK F8W0G4;F8V XH9;F8W1G6 ;H3BRU6;F8V ZX2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;H3BND9;J3 QT27;E9PFP 8;P ;P ;P ;P ;P57721 Poly(rC)-binding protein 2;Poly(rC)- binding protein 3 BP2;BP E NKTHTLCR NLAGECQNIN K D6R9X9;D6R G19;P61927 Q8WXH0;Q8 WXH0-2;G3V5X4;A0 A0A0MRE3 Ribosomal L37;60S protein L37 protein ribosomal RPL E Nesprin-2 SYNE2 8.15E TSNKPLMIIHH LDECPHSQAL KK Oxidation (M); C9J3E2;B5M C07;O95994 Anterior gradient protein 2 homolog AGR2 3.45E KCPFYAAEQD K A0A087WT44 ;P ;P30519;I3L 1Y2 Heme oxygenase 2 HMOX2 4.30E VTQNLPMKE GCTEVSLLR DRPSPSR CIELCCGSVK FAEVECLAES HQHLSK Oxidation (M); H3BQZ7;Q1K MD3 O ;O ;O ;O95758;O ;O ;B1ALY4;X6 R242 2 Carbamidomet hyl (C);IAAyne P ;P ;P ;P05023 F5GWX5;Q14 839;Q Heterogeneous nuclear ribonucleoprotein U- like protein 2 Polypyrimidine tractbinding protein 3 Sodium/potassiumtransporting ATPase subunit alpha-1 Chromodomainhelicase-DNA-binding protein 4 HNRNPUL2- BSCL2;HNRN PUL2 5.68E PTBP3 1.00E ATP1A1 5.12E CHD4 2.38E S227

228 EKEELDRGC R GCVTEEENTN VK K7EQA9;K7E KQ2;Q16543 H7C1F9;Q2P PJ7-3;Q2PPJ7-2;Q2PPJ7 Hsp90 co-chaperone Cdc37;Hsp90 cochaperone Cdc37, N- terminally processed Ral GTPase-activating protein subunit alpha-2 CDC E RALGAPA2 9.46E GGTLFGGEV CK P42166 Lamina-associated polypeptide 2, isoform alpha;thymopoietin;t hymopentin TMPO 3.24E IRDTSQEG R A0A087WUY 3;A0A087WZ 65;A0A087W TF3;Q ;Q ;Q ;Q ;Q12955 Ankyrin-3 ANK3 5.26E GVSINQFCK CLFGGQEPAP K YIQAACK LCIGNITNK LTGIKHELQA NCYEEVKDR AVLFCLSEDK K CVSHVQVDS R CAAQTLEK CIYEIFSK CSLHSASPAS VR CSNHLQDKIQ K KGCNPLAQT GR QIDKIQCAK E9PQB6;Q9Y 3B7-2;Q9Y3B7-3;Q9Y3B7 A0A0A0MSU 2;Q6PJG2;C9 JYU7 A0A087WVQ 6;Q ;Q00610;A0 A087WX41;P ;P53675 F5H2U7;Q8N C96 G3V1A4;E9P P50;E9PK25; P23528 G3V1A4;E9P P50;E9PK25; P23528;E9PL J3;E9PS23;E 9PQB7 B1AMN9;Q9H 7E2;Q9H7E2-3 E9PQ61;O F5H0I7;B4E1 27;G8JL98;Q Q9P206;Q9P 206-3;Q9P206-2 J3QLM2;J3K RR6;F5H478; J3KRU5;X6R 3T8;J3QLH3; J3QQJ0;Q9U HR5-2;Q9UHR5 K7EL35;Q8IU C4 Q8WVM7-2;Q8N3U4;Q8 WVM7;Q8N3 U4-2 39S ribosomal protein L11, ELM2 and SANT domain-containing protein 1 Clathrin heavy chain 1;Clathrin heavy chain 2 Adaptin ear-binding coat-associated protein 1 MRPL E ELMSAN1 4.62E CLTC;CLTCL1 3.09E NECAP1 4.02E Cofilin-1 CFL1 3.66E Cofilin-1 CFL1 3.26E Tudor domaincontaining protein 3 Zinc finger CCCH domain-containing protein 11A G/T mismatch-specific thymine DNA glycosylase Uncharacterized protein KIAA1522 TDRD3 3.06E ZC3H11A 5.58E TDG 5.10E KIAA E SAP30-binding protein SAP30BP 5.45E Rhophilin-2 RHPN2 3.80E Cohesin subunit SA- 1;Cohesin subunit SA- 2 STAG1;STAG E S228

229 CQYVTEK LNGGLGTSM GCKGPK P04075;P ;J3KPS3;H3 BPS8;H3BQN 4;P09972 C9JUW1;C9J WG0;C9JVG3 ;C9JQU9;C9J NZ1;A0A087 WYS1;E7EU C7;Q ;Q16851 Fructosebisphosphate aldolase A;Fructosebisphosphate aldolase C UTP--glucose-1- phosphate uridylyltransferase ALDOA;ALDO C 3.43E UGP2 1.02E CSTPEEIK P ;P60981;F6 RFD5 Destrin DSTN 3.44E KKTATAVAHC K M0R210;P622 49;M0R3H0;Q 6IPX4 40S ribosomal protein S16 RPS E LIFKNCER DGLKHTCVK CDKTVYFAEK H0Y612;E7E N20;Q9UPN9-2;Q9UPN9 J3QRI1;Q9BV V7 P52943;H0YH D8 E3 ubiquitin-protein ligase TRIM33 Mitochondrial import inner membrane translocase subunit Tim21 TRIM E TIMM E Cysteine-rich protein 2 CRIP2 1.81E CLKKDDESNL VEEK G5E9S8;G3V 2E7;F8W6L3; G3V3H3;G3V 5R9;E7EVH7; Q ;Q ;Q ;Q07866;Q ;Q ;Q ;Q ;Q ;Q ;G3V2P7 Kinesin light chain 1 KLC1 1.75E NKDEGDVCN HEKK S4R3D7;S4R 3V1;F6XEV2; Q9BPX6-2;Q9BPX6;Q9 BPX6-3 Calcium uptake protein 1, MICU1 3.14E TSNKPLMIIHH LDECPHSQAL KK NCLALADDKK LK ASFENNCEIG CFAK B4DJC3;O ;O ;O75367 F8WD20;B7Z BH1;F8WDS6 ;P ;P56537 Carbamidomet hyl (C);IAAyne C9J3E2;B5M C07;O95994 Anterior gradient protein 2 homolog Histone H2A;Core histone macro-h2a.1 Eukaryotic translation initiation factor 6 AGR2 3.88E H2AFY 9.54E EIF6 4.39E S229

230 Table S5: Competitive ABPP-DML with 200 nm lomeguatrib pretreatment followed by iodoacetamide alkyne treatment. Sequence Modifications Protein Ids Protein Names Gene Names PEP DML ratio Lomeguatrib/DMSO GNPVPILIP CHR IVFVPGCSI PLTIVK NVQLLSQF VSPFTGCIY GR P16455 P54136;P Q9Y3D5 Methylated- DNA--proteincysteine methyltransferas e Arginine--tRNA ligase, cytoplasmic 28S ribosomal protein S18c, SEM MGMT 7.22E RARS 1.65E MRPS18C 7.14E TFVSGACD ASIK QIELACDSQ EDVDSWK P62879;C9J IS1;C9JXA5; E7EP32;P P ;P ;P ;P ;P50570 Guanine nucleotidebinding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 8.09E Dynamin-2 DNM2 1.76E ACANPAAG SVILLENLR SARRLCEL CCANR Carbamidomet hyl (C);IAAyne P ;P00558 F8W9Q8;G3 V426;Q86T W2-2;Q86TW2 Phosphoglycerat e kinase 1 Uncharacterized aarf domaincontaining protein kinase 1 PGK1 2.55E ADCK1 2.45E LVENDVAGI DVNMGCPK DIKWDFTP CK Q9NX74;I3L 4H0;I3L4Y9; J3QLD5 P ;P38606;C 9JA17;C9JV W8 trnadihydrouridine(2 0) synthase [NAD(P)+]-like V-type proton ATPase catalytic subunit A DUS2 2.12E ATP6V1A 1.91E TCDGVQCA FEELVEK Carbamidomet hyl (C);IAAyne Q5W0J0;A0 A087X163;H 0Y6T8;Q9N P72;Q9NP7 2-2;Q9NP72-3 Ras-related protein Rab-18 RAB E CSLPAEED SVLEK KGTDIMYT GTLDCWRK VQTLEELEE LGKEECFQ NK AVYSTNCP VWEEAFR E7EVA0;P ;P27816 P05141 Q9BVJ6-2;Q9BVJ6-3;Q9BVJ6 Q9BSJ8;Q9 BSJ8-2 Microtubuleassociated protein;microtub ule-associated protein 4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed U3 small nucleolar RNAassociated protein 14 homolog A Extended synaptotagmin-1 MAP4 8.10E SLC25A5 1.39E UTP14A 2.96E ESYT1 4.64E S230

231 FGEVVDCT LKLDPITGR H0YA96;H0 Y8G5;Q ;Q ;Q ;Q14103;D 6RD83;D6R F44;D6RBQ 9;D6RAF8 Heterogeneous nuclear ribonucleoprotei n D0 HNRNPD 5.28E QFLDFGSS NACEK CPFVENTW K LVEALCAEH QINLIK ALAGCDFLT ISPK DSPQSLTD ESCSEK Q15119 Q5JPI3-2;Q5JPI3 P25398 F2Z393;P Q9BV36-4;Q9BV36-2;Q9BV36 [Pyruvate dehydrogenase (acetyltransferring)] kinase isozyme 2, Uncharacterized protein C3orf38 PDK2 8.05E C3orf E S ribosomal RPS E protein S12 Transaldolase TALDO1 1.59E Melanophilin MLPH 6.69E GLTELFV APVGVASK R H0Y901;E9 PDI4;O Ladinin-1 LAD1 4.39E VVCDENGS KGYGFVHF ETQEAAER A0A087WTT 1;E7EQV3;P ;P11940;E 5RGH3 Polyadenylatebinding protein 1 PAB1 8.19E SAVDYNTC AGVWSQDK WK A0A087WX Z3;Q9Y5A9-2;Q9Y5A9 YTH domaincontaining family protein 2 YTHDF2 4.14E EGRLEDVE NLGCR DIDDDLEGE VTEECGKF GAVNR Q9UJX3-2;Q9UJX3 Q9UHX1-4;Q9UHX1-6;Q9UHX1-3;Q9UHX1-5;Q9UHX1-2;Q9UHX1 Anaphasepromoting complex subunit 7 Poly(U)-bindingsplicing factor PUF60 ANA7 7.86E PUF E GLTELFV APVGVASK IAAYLQSDQ FCK H0Y901;E9 PDI4;O Ladinin-1 LAD1 1.59E P21266 Glutathione S- transferase Mu 3 GSTM3 1.92E S231

232 ARQYPWGV VQVENENH CDFVKLR E7EW69;E7 EX04;B5ME 97;Q9P0V9; Q9P0V9-2;D6RDU5; D6RGI3;A0 A087X142;A 6NMH6;D6R ER5;A6NFQ 9;F8W8I8;Q ;Q9NVA2; Q ;Q9P0V9-3;Q9NVA2-2;Q ;Q92599 Septin- 10;Septin- 8;Septin-11 SEPT10;SEPT 11;SEPT8 1.02E SEETNTEIV ECILK A0A087WV6 6;P46013;P Antigen KI-67 MKI E EAAASGLPL MVIIHKSWC GACK LRLTVVDTP GYGDAINC RDCFK Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne O95881 C9IY94;C9I ZU3;C9JQJ 4;C9J938;H 7C310;C9JB 25;C9J2Q4; B5MCX3;Q1 5019;Q ;Q Thioredoxin domaincontaining protein 12 TXNDC E Septin-2 SEPT2 3.54E NTGIICTIGP ASR B4DNK4;P1 4618;H3BTJ 2;H3BQ34;H 3BU13;H3B T25;H3BUW 1;P ;H3BTN5 Pyruvate kinase;pyruvate kinase PKM PKM 3.10E VACITEQVL TLVNK AITIAGVPQ SVTECVK VYAVATST NTAR YLVLDCVPE ER IVLTNPVCT EVGEK ESTGNMVT GQTVCK Oxidation (M); B7Z4L4;P Q15365 Q10570 O ;O14776 Q2VIR3;P E7EN77;Q Dolichyldiphosphooligos accharide-- protein glycosyltransfera se subunit 1 Poly(rC)-binding protein 1 Cleavage and polyadenylation specificity factor subunit 1 Transcription elongation regulator 1 Putative eukaryotic translation initiation factor 2 subunit 3-like protein;eukaryoti c translation initiation factor 2 subunit 3 Condensin complex subunit 1 RPN1 1.46E BP1 2.17E CPSF1 3.09E TCERG1 1.83E EIF2S3L;EIF2 S3 1.82E NCAPD2 7.11E S232

233 ISPFEHQTY CQR YDNSLKIIS NASCTTNC LAPLAK EMIQKECA AIR Carbamidomet hyl (C);IAAyne P ;P28482;E 9PBK7;E9P JF0;E9PQW 4;P ;P ;P27361 E7EUT5;P ;P04406 H3BN75;H3 BS13;H3BV 30;H3BRM7; H3BN71;B4 DGE1;H3BR 36;H3BUN9; H3BNR4;O4 3747;O Mitogenactivated protein kinase 1;Mitogenactivated protein kinase;mitogenactivated protein kinase 3 Glyceraldehyde- 3-phosphate dehydrogenase AP-1 complex subunit gamma- 1 MAPK1;MAPK E GAPDH 6.13E AP1G1 1.01E GIGMNEPL VDCEGYPR SDVDLYQV R F5H7X1;F5 H5V4;F5GX 23;J3KN29; O ;O S proteasome non-atpase regulatory subunit 9 PSMD9 4.49E VVCSSGAV GNYSGGLA VKEWLLAH EGHR SQGGEEEG PLSDKCSR YGINTTDIF QTVDLWEG KNMACVQR Oxidation (M); P16455 E9PR76;E9 PSH4;Q9H0 63 X6RJP6;P37 802;P Methylated- DNA--proteincysteine methyltransferas e MGMT 7.47E Repressor of MAF1 2.80E RNA polymerase III transcription MAF1 homolog Transgelin-2 TAGLN2 1.44E IIDINYYPVP EACLSNKR QFSTPFQL QCHLENVH SPYESTTK E9PL69;P Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Ribonucleosidediphosphate reductase large subunit Pogo transposable element with ZNF domain RRM1 6.88E POGZ 1.14E VCENIPIVL CGNKVDIK DR Carbamidomet hyl (C);IAAyne B4DV51;F5 H018;B5MD F5;J3KQE5; P62826 GTP-binding nuclear protein Ran RAN 4.34E SYCNDQST GDIKVIGGD DLSTLTGK LLDLVQQS CNYKQLR CEGINISGN FYR NALVSHLD GTTPVCEDI GR ENPKVVNEI NIEDLCLTK P00492 B1AHD1;P M0QYS1;P Hypoxanthineguanine phosphoribosyltr ansferase NHP2-like protein 1;NHP2- like protein 1, N- terminally processed 60S ribosomal protein L13a P31930 Cytochrome b- c1 complex subunit 1, D6RCF4;Q8 N5K1 CDGSH ironsulfur domain- HPRT1 3.78E NHP2L1 4.13E RPL13A 7.15E UQCRC1 4.71E CISD2 1.29E S233

234 containing protein 2 VATRGLCAI AQAESLR P23396;P ;F2Z2S8;H 0YF32;H0Y CJ7 40S ribosomal protein S3 RPS3 3.67E CMALSTAV LVGEAK FRKAQCPIV ER TSAVPS GKYYTLNG SK LQLTLYQYK TCPFCSK FQEHCPDL ERQEAEVH K Carbamidomet hyl (C);IAAyne G3V4Z4;Q ;Q02252 M0R0F0;M0 R0R2;P P ;P49748;P Q9H7Z7 K7EKI8;O60 437;K7EQ71 Methylmalonatesemialdehyde dehydrogenase [acylating], ALDH6A1 1.29E S ribosomal RPS5 1.86E protein S5;40S ribosomal protein S5, N- terminally processed Very long-chain ACADVL 1.84E specific acyl- CoA dehydrogenase, Prostaglandin E PTGES2 2.70E synthase 2;Prostaglandin E synthase 2 truncated form Periplakin PPL 2.95E ACKVDSPT VTTTLK G5E9S8;G3 V2E7;F8W6 L3;G3V3H3; G3V5R9;E7 EVH7;Q ;Q ;Q ;Q07866;Q ;Q ;Q ;Q ;Q ;Q ;H0YJU9;H 0YJL0;H0YJ T3;H0YG16 Kinesin light chain 1 KLC1 8.75E CRDPPSNP VAASPR CAGPTPEA ELQALAR LTVVDTPG YGDAINCR DCFK Carbamidomet hyl (C);IAAyne Q8ND82;Q9 UJJ2 Q15050 C9IY94;C9I ZU3;C9JQJ 4;C9J938;H 7C310;C9JB 25;C9J2Q4; B5MCX3;Q1 5019;Q ;Q Zinc finger protein 280C ZNF280C 1.91E Ribosome biogenesis regulatory protein homolog RRS1 1.55E Septin-2 SEPT2 2.94E EIGPNDGFL AQLCQLND R K7ELG5;P ;P51452 Dual specificity protein phosphatase 3 DUSP3 6.95E S234

235 ELPPDQAE YCIAR O ;O43707;F 5GXS2;O ;H9KV75;P ;P12814;P ;P ;H0YJW3; H7C144 Alpha-actinin- 4;Alpha-actinin-1 ACTN4;ACTN E ASVGFGGS CFQK O60701;O ;O UDP-glucose 6- dehydrogenase UGDH 1.31E YGIICMEDLI HEIYTVGKR LLPDDPYEK ACQK A8MUD9;P Q5TA01;Q5 TA02;P ;P ;P S ribosomal protein L7 Glutathione S- transferase omega-1 RPL7 3.02E GSTO1 1.95E GIGMNEPL VDCEGYPR SDVDLYQV R Oxidation (M); F5H7X1;F5 H5V4;F5GX 23;J3KN29; O ;O S proteasome non-atpase regulatory subunit 9 PSMD9 4.49E GPSLQGDL AVSGDIKCP K VGIIPPKGC LLYGPPGT GK Q09666 H0YJS8;H0 YJC0;A0A08 7X2I1;P Neuroblast differentiationassociated protein AHNAK 26S protease regulatory subunit 10B AHNAK 5.11E PSMC6 1.52E KVIGIECSSI SDYAVK E9PKG1;H7 C2I1;Q ;Q ;Q ;Q99873;E 9PIX6;A0A0 87X1W2;E9 PMW9;E9PI 83;E9PNR9; E9PQ98;H0 YDE4 Protein arginine N- methyltransferas e 1 PRMT1 4.76E RSIQFVDW CPTGFK TIIPLISQCT PK ISASCQHPT AFEEAIPK GFGTDEQAI IDCLGSR FSGDLDDQ TCREDLHIL FSNHGEIK P ;P ;P68366;P P ;P40926;G 3XAL0 C9JBE1;E7 EMB6;E7ET B3;Q9ULA0 P ;P50995 Tubulin alpha- 1B chain;tubulin alpha-4a chain Malate dehydrogenase, ;M alate dehydrogenase Aspartyl aminopeptidase TUBA1B;TUB A4A 7.80E MDH2 1.14E DNPEP 2.99E Annexin A11 ANXA E P05455 Lupus La protein SSB 2.74E S235

236 CPTSGRLE QQLVHVER PILR C9JBE1;E7 EMB6;E7ET B3;Q9ULA0; C9JRG3;C9 J1E2;E7EP X3;B9ZVU2; F8WAN0 Aspartyl aminopeptidase DNPEP 3.74E RPLNPLAS GQGTSEEN TFYSWLEG LCVEKR QDKCALGW DHQEK ARGGCPGG EATLSQPP PRGGTR ALVKEQGD RICR GKDCAVIVT QK Q96HE7 Q ;Q14247;Q P20290 ERO1-like protein alpha Src substrate cortactin Transcription factor BTF3 ERO1L 2.81E CTTN 4.51E BTF3 1.05E Q9BR76 Coronin-1B CORO1B 1.67E G3V3U4;G3 V3I1;G3V29 5;G3V5Z7;P ;P60900 Proteasome subunit alpha type;proteasom e subunit alpha type-6 PSMA6 1.49E LYLDELEG GGNPGASC K LLDAQLATG GLVCPAR F5H1Y4;Q9 HD26-2;Q9HD26 A0A075B73 0;A0A087X1 U6;P58107 Golgi-associated PDZ and coiledcoil motifcontaining protein GO 3.89E Epiplakin EPPK1 8.33E GGAARPNG PAAGNKIC QFK F8VSF8;F8 VWU4;F8VV K3;K7ERI8; K7ERQ8;P5 1148;P Ras-related protein Rab-5C RAB5C 2.36E EAAFSPGQ QDWSRDFC IEASER RLECLKED VQR VGTGEC DWVGDEG AGHFVK ICDDELILIK Carbamidomet hyl (C);IAAyne Q9C0C2-2;Q9C0C2 Q99459 P ;P52209;K 7EM49;K7E PF6 E7ERF2;P1 7987;F5GZ0 3;F5H282;E 7EQR6 182 kda tankyrase-1- binding protein Cell division cycle 5-like protein 6- phosphoglucona te dehydrogenase, decarboxylating T-complex protein 1 subunit alpha TNKS1BP1 5.59E CDC5L 8.20E PGD 5.03E TCP1 4.39E RSEVEEVD FAGWLCK ALNVEPDG TGLTCSLAP NIISQL M0R1B6;G5 E9C7;P P ;P ;P30044;P Dual specificity mitogenactivated protein kinase kinase 2 Peroxiredoxin-5, MAP2K2 2.11E PRDX5 1.47E S236

237 AQFEYDPA KDDLIKE AGIR Q5JS79;Q5J S72;O ;O ;O ;O ;O ;O14936 Peripheral plasma membrane protein CASK CASK 2.14E CYYSNTDA VIYVVDSCD RDR Carbamidomet hyl (C);IAAyne B4DZG7;F8 VYN9;P ;P40616 ADP-ribosylation factor-like protein 1 ARL1 1.65E YSNSALGH VNCTIKELR H7C106;F8 W914;Q9NQ C3-3;Q9NQC3-2;Q9NQC3-5;Q9NQC3-4;Q9NQC3-6;Q9NQC3 Reticulon;Reticul on-4 RTN4 1.12E NIQACKELA QTTR P ;P50990;H 7C4C8 T-complex protein 1 subunit theta CCT8 7.87E CMPTFQFF K DVLNLVYLC EALNLPEVA R Oxidation (M); P ;P10599 O60701;O ;O Thioredoxin TXN 5.64E UDP-glucose 6- dehydrogenase UGDH 7.86E CSSLYEER LFSVPDFV GDACK LGEWVGLC K AVASQLDC NFLK Q9Y4D7-2;Q9Y4D7 Q14764 P25398 H0YJS8;H0 YJC0;A0A08 7X2I1;P Plexin-D1 PLXND1 7.62E Major vault protein 40S ribosomal protein S12 26S protease regulatory subunit 10B MVP 2.28E RPS E PSMC6 2.40E LAGLTCSG AEGLARPK ILAVSFAPLI QHSESG K QYPWGVV QVENENHC DFVKLR Q8WV74 V9GYG6;F8 W9F3;Q9NV 79 E7EW69;E7 EX04;B5ME 97;Q9P0V9; Q9P0V9-2;D6RDU5; D6RGI3;A0 A087X142;A 6NMH6;D6R ER5;A6NFQ 9;F8W8I8;Q ;Q9NVA2; Q ;Q9P0V9-3;Q9NVA2-2;Q ;Q92599 Nucleoside diphosphatelinked moiety X motif 8, Protein-Lisoaspartate O- methyltransferas e domaincontaining protein 2 Septin- 10;Septin- 8;Septin-11 NUDT8 4.11E MTD2 1.29E SEPT10;SEPT 11;SEPT8 2.22E S237

238 GAVEKGEE LSCEERNLL SVAYK YMLDCR TVDEACLLL AEYNGR FLCESVFSY QVASTLK NVDAILEEY ANCKK Oxidation (M); P31947;P Q9Y277;Q9 Y277-2 Q9NQG5;A0 A087X2D2; A2A2M0 Q96DE5 Q5JXX2;A0 A088AWL8; A0A0A0MT5 9;Q protein sigma Voltagedependent anion-selective channel protein 3 Regulation of nuclear premrna domaincontaining protein 1B Anaphasepromoting complex subunit 16 Mortality factor 4-like protein 2 SFN 0.00E VDAC3 1.94E RPRD1B 2.28E ANA E MORF4L2 3.72E KACPLQPD HTNDEKE TQADELPA CLLSAAR ISPVDVNSR PSSCLTNFL LNGR H0YKX3;Q Q96II5;P H0YI01;H0Y H12;Q9NVM 9-2;Q9NVM9 NAassociated factor Serine/threonine -protein kinase A-Raf Protein asunder homolog KIAA E ARAF 1.00E ASUN 2.40E AGSDGAKI GNCPFSQR ILQDVADEE IAALPRDSC PVR ESAQCVGD EFLNCK VRYSLDPE NPTKSCK Carbamidomet hyl (C);IAAyne O00299 O60783 C9J8E6;C9J 014;C9J271; Q9Y5X2 A0A087WX M6;J3QQT2; J3KRX5;P18 621;P ;A0A087W Y81;J3KRB3 ;A0A087WW H0;J3QS96; J3KSJ0 Chloride intracellular channel protein 1 CLIC1 1.06E S ribosomal MRPS E protein S14, Sorting nexin-8 SNX8 2.15E S ribosomal protein L17 RPL E GCYIGQELT AR AVEEDGHL KCPR CLSVMEAK Q5T440 Q9P275;Q9 P275-2 H3BPK7;P4 9588;P Putative transferase CAF17, Ubiquitin carboxylterminal hydrolase 36 Alanine--tRNA ligase, cytoplasmic IBA E USP E AARS 4.35E ALDLDSSC KEAADGYQ R P ;P31948;P ;H0YGI8 Stress-inducedphosphoprotein 1 STIP1 1.58E S238

239 SAFLCGVM K O ;O ;O ;O60506;F 6UXX1;O ;O43390;O Heterogeneous nuclear ribonucleoprotei n Q;Heterogeneou s nuclear ribonucleoprotei n R SYNCRIP;HN RNPR 4.05E LPLEQCTG SSR QGFWEEFE TLQQQECK KIWCFGPD GTGPNILTD ITK CVDEVAFQ EEVVAVLKK Q9HCU4 Q ;Q ;Q06124 P13639 C9JGY5;F8 WE44;C9JX Z7;C9JTT7; C9J8M3;C9 JZI1;P ;P35249 Cadherin EGF LAG seven-pass G-type receptor 2 Tyrosine-protein phosphatase non-receptor type 11 Elongation factor 2 Replication factor C subunit 4 CELSR2 1.92E PTPN E EEF2 4.76E RFC4 2.17E DKISDSND QESANCDA K QDEHGYIS RCFTR LDPTGTFEK EMIGRIG R KLQDLAGGI FPEDEIPEK ACR AVLCPPPV KK NAPQNSTQ AHSENKCS GASQKLPR SSGQSAQL LSHEPGDP LR Oxidation (M); H7C0C0;Q9 Y5Q9 P04792 Q ;Q16698 P56182 P63000;P60 763;P Q9H9L3 H3BVG0;Q8 N1F7-2;Q8N1F7 General transcription factor 3C polypeptide 3 Heat shock protein beta-1 2,4-dienoyl-CoA reductase, Ribosomal RNA processing protein 1 homolog A Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 3 Interferonstimulated 20 kda exonuclease-like 2 Nuclear pore complex protein Nup93 GTF3C3 3.81E HSPB1 1.02E DECR1 1.26E RRP1 4.45E RAC1;RAC3 1.48E ISG20L2 1.43E NUP E QADSDIPLD RLTISYCR ADPAIKEPL PVEDVCPK J3KS15;Q I3L2A2;I3L2 N7;Q ;Q92667;I3 L0K6;I3L3K 1;I3L364 Peptidyl-tRNA hydrolase ICT1, A-kinase anchor protein 1, ICT1 1.33E AKAP1 1.82E VLDLLDPAS GDLVIREDC R H3BTH5;H3 BRB3;Q ;Q14807 Kinesin-like protein KIF22 KIF E GIIYNED NGIIK CKAFTTR P36578;H3B M89 P17858;P S ribosomal protein L4 ATP-dependent 6- phosphofructoki nase, liver type RPL4 6.16E PFKL 6.89E S239

240 KCPFYAAE QDKGALEG SSCPFR TVFAEHISD ECKR Carbamidomet hyl (C);IAAyne A0A087WT4 4;P ;P30519 B5MCW2;H 7C422;G5E 9G0;P39023 ;F8WCR1;H 7C3M2 Heme oxygenase 2 60S ribosomal protein L3 HMOX2 1.52E RPL3 1.65E FSLCSDNLE GISEGPSN R A0A0A0MQ V8;B4DGD8 ;H0Y7I9;C9I Z08;Q14C86-3;Q14C86-5;Q14C86-2;Q14C86;Q 14C86-6 GTPaseactivating protein and VPS9 domaincontaining protein 1 GAPVD1 1.06E TIAQK EATDPR EVENAVES WR H0YBG6;P F8W9N7;P4 7755;C9JU G7;P Stress-70 protein, F-actin-capping protein subunit alpha-2 HSPA9 2.93E CAPZA2 3.67E VCEDLDTS VNLAWTSG TNCTR YLECSALTQ R TAFLAEDFN PEEINLDCT NPR CELSSSVQ TDINLPYLT MDSSGPK LDPTGTFEK EMIGRIG R CMALSTAV LVGEAK ERICSEEER AK Carbamidomet hyl (C);IAAyne Oxidation (M); Oxidation (M); A0A0A0MR 02;P ;P45880;P P63000;P60 763;P ;B1AH78;P 15153;J3KS C4;J3QLK0; B1AH77;B1 AH80 Q5HYI8 H0YBG6;P Q ;Q16698 G3V4Z4;Q ;Q02252 C9JRZ6;F8 WAR4;Q9N X63 Voltagedependent anion-selective channel protein 2 Ras-related C3 botulinum toxin substrate 1;Rasrelated C3 botulinum toxin substrate 3;Rasrelated C3 botulinum toxin substrate 2 Rab-like protein 3 Stress-70 protein, 2,4-dienoyl-CoA reductase, Methylmalonatesemialdehyde dehydrogenase [acylating], MICOS complex subunit MIC19 VDAC2 0.00E RAC1;RAC3;R AC2 4.78E RABL3 1.10E HSPA9 1.35E DECR1 1.26E ALDH6A1 1.29E CHCHD3 5.44E APVAGTCY QAEWDDYV PK NLDKEYLPI GGLAEFCK LQAANDSV CR P30086 P00505 H3BN57;Q8 TDH9-3;Q8TDH9 Phosphatidyleth anolaminebinding protein 1;Hippocampal cholinergic neurostimulating peptide Aspartate aminotransferas e, Biogenesis of lysosomerelated organelles complex 1 subunit 5 PEBP1 1.94E GOT2 2.76E BLOC1S5- TXNDC5;BLO C1S5 4.24E S240

241 ELAQQVQQ VADDYGKC SR H3BLZ8;Q ;Q ;Q ;Q92841 Probable ATPdependent RNA helicase DDX17 DDX E CLPTPK CSESSDSG SGFWK M0R117;Q P09912;P ;P S ribosomal protein L18a Interferon alphainducible protein 6 RPL18A 1.43E IFI6 1.44E CRGGAGSG TGGGPGLG SR IQCTLQDVG SALATSS AR TIDGQQTIIA CIESHQFQP K VMTIPYQP MPASSPVIC AGGQDR DLAGAPPG EVVGCFTP QSR IEGCIIGFDE YMNLVLDD AEEIHSK TTASEPVE QSEATSKD CSR IIPTLEEYQH YKGSDFDC ELR EVFSSCSS EVVLSGDD EEYQR ASFETLPNI SDLCLR Carbamidomet hyl (C);IAAyne Oxidation (M); Oxidation (M); F8WFE0;Q8 WVR3 F5H4Z7;S4 R3P5;Q96E Y8 P52907 Q15365 Q9Y446;Q9 Y446-2 A6NHK2;P Q15007 Q5T6W2;Q5 T6W5;P Q09666;E9P KR9;E9PLK 4 E9PRW1;E9 PSD6;C9JF 50;E9PLU1; E9PRK5;Q9 H019-2;Q9H019-3;Q9H019 Uncharacterized protein C7orf43 Cob(I)yrinic acid a,c-diamide adenosyltransfer ase, F-actin-capping protein subunit alpha-1 Poly(rC)-binding protein 1 C7orf E MMAB 4.05E CAPZA1 1.89E BP1 2.53E Plakophilin-3 PKP3 8.86E Small nuclear ribonucleoprotei n E Pre-mRNAsplicing regulator WTAP Heterogeneous nuclear ribonucleoprotei n K Neuroblast differentiationassociated protein AHNAK Mitochondrial fission regulator 1-like SNRPE 1.92E WTAP 2.42E HNRNPK 3.20E AHNAK 4.67E MTFR1L 1.59E GVLFGVPG AFTPGCSK P ;P ;P30044 Peroxiredoxin-5, PRDX5 4.63E LNISFPATG CQK CTWLTTPK P62753;A2A 3R7 H3BMJ8;H3 BSP8;Q9BQ 70;H3BSS3; H3BQ53 40S ribosomal protein S6 Transcription factor 25 RPS6 1.07E TCF E STGVVNIPA AECLDEYE DDEAGQKE R SACGVCPG RLR FLATEGAP DFLCPEELE HVSR Carbamidomet hyl (C);IAAyne H0YI16;Q96 IZ0 P49207 PRKC apoptosis WT1 regulator protein 60S ribosomal protein L34 PAWR 5.08E RPL E Q6ZRV2 Protein FAM83H FAM83H 2.04E S241

242 GFSIPECQK F8W642;F8 VZK9;F8VX 07;F8VRP1; F8VX68;F8V WQ5;F8VRI 6;F8VPF9;F 8VPA1;F8V TT8;F8W1S 4;F8W4S1;H 0YH82;B4D JV2;O75390 Citrate synthase;citrate synthase, CS 1.01E SSGGFVWA CK VQREETEV LEASLCSLR ANCIDSTAS AEAVFASE VK P ;P48735;H 0YL11 B4DHR0;Q9 H5N1 M0QXL5;M0 R2Q4;P220 87;M0R299 Isocitrate dehydrogenase [NADP], Rab GTPasebinding effector protein 2 rrna 2'-Omethyltransferas e fibrillarin IDH2 1.86E RABEP2 2.23E FBL 7.02E DVQIGDIVT VGECRPLS K GFSIPECQK LLPK P62280;M0 R1H5 F8W642;F8 VZK9;F8VX 07;F8VRP1; F8VX68;F8V WQ5;F8VRI 6;F8VPF9;F 8VPA1;F8V TT8;F8W1S 4;F8W4S1;H 0YH82;B4D JV2;O S ribosomal protein S11 Citrate synthase;citrate synthase, RPS E CS 7.29E AIQTVSCLL QGDAGN R KPTDGASS SNCVTDISH LVR Carbamidomet hyl (C);IAAyne Q9H3U1-2;Q9H3U1 H0YDS9;Q5 T624;P ;P ;P49321;P Protein unc-45 homolog A Nuclear autoantigenic sperm protein UNC45A 1.27E NASP 1.29E LCSSSDTLV SEGEENQK PK DAGGKSW CPDCVQAE PVVR GQKCEFQD AYVLLSEKK QVCQLPGL FSYAQHIAS IDGRR SEGGFIWA CK CALGWDHQ EK Carbamidomet hyl (C);IAAyne Q5T0W9 Protein FAM83B FAM83B 5.66E I3L0K2;I3L3 M7;Q9BRA2 P10809 Q9Y6C9;E9 PIE4 O75874 Thioredoxin domaincontaining protein kda heat shock protein, Mitochondrial carrier homolog 2 Isocitrate dehydrogenase [NADP] cytoplasmic Src substrate cortactin Q ;Q14247;Q TXNDC E HSPD1 1.86E MTCH2 9.96E IDH1 1.42E CTTN 8.35E S242

243 VPFLVLECP NLK CSVKNDHS AYKR ISSPTETER CIESLIAVFQ K YMLDCR AVCLLTGAS R QGFGNLPIC MAK VCEEIAIIPS KK Oxidation (M); A0A087WU D3;Q9NRP0 ;Q9NRP0-2 A0A087WT Q3;A0A087 WWZ1;E7E VJ5;Q96F07-2;Q7L576;Q 96F07 Oligosaccharyltr ansferase complex subunit OSTC Cytoplasmic FMR1- interacting protein 2;Cytoplasmic FMR1- interacting protein 1 P31949 Protein S100- A11;Protein S100-A11, N- terminally processed Q9Y277;Q9 Y277-2 P35270 F5H2F4;P11 586;V9GYY 3 H0YN73;H0 YN88;A0A0 75B716;P0C W22;P Voltagedependent anion-selective channel protein 3 Sepiapterin reductase C-1- tetrahydrofolate synthase, cytoplasmic;met hylenetetrahydro folate dehydrogenase; Methenyltetrahy drofolate cyclohydrolase;f ormyltetrahydrof olate synthetase;c-1- tetrahydrofolate synthase, cytoplasmic, N- terminally processed 40S ribosomal protein S17- like;40s ribosomal protein S17 OSTC 9.74E CYFIP2;CYFI P1 1.73E S100A E VDAC3 1.94E SPR 4.00E MTHFD1 2.41E RPS17;RPS17 L 3.96E SSFREEDN TYRCR H3BN75;H3 BS13;H3BV 30;H3BRM7; H3BN71;B4 DGE1;H3BR 36;H3BUN9; H3BNR4;O4 3747;O AP-1 complex subunit gamma- 1 AP1G1 5.82E EADEGCKK PLER EGGQYGLV AACAAGGQ GHAMIVEA YPK Oxidation (M); Q9NQG5 B5MD38;F5 GZQ3;P ;P55084 Regulation of nuclear premrna domaincontaining protein 1B Trifunctional enzyme subunit beta, ;3- ketoacyl-coa thiolase RPRD1B 1.72E HADHB 1.21E S243

244 YKWCEYGL TFTEK A0A0A0MR 02;P ;P45880;P ;A2A3S1;Q 5JSD2;Q5J SD1 Voltagedependent anion-selective channel protein 2 VDAC2 5.82E ASEDGESV GHCPSCQR LGEMIETAY GENFACSK IAILTCPFEP PKPK 2 Oxidation (M); O95833 Q8IYQ7 E7ENZ3;B7 ZAR1;E9 A1;P ;P48643 Chloride intracellular channel protein 3 Threonine synthase-like 1 T-complex protein 1 subunit epsilon CLIC3 7.16E THNSL1 2.44E CCT5 4.07E QLFALSCTA EEQGVLPD DLSGVIR P ;P ;P ;P ;P04899;P Guanine nucleotidebinding protein G(i) subunit alpha-2 GNAI2 0.00E AKADPDCS NGQPQAAP TPGAPQNR K IDRYTQQG FGNLPICMA K GCLGNSKT EDQRNEEK Q9BW85 A0A087WV M4;B7ZM99; Q6UB35;Q4 VXM0 P ;P ;P63092;P ;Q5JWD1; A0A0A0MR 13 Coiled-coil domaincontaining protein 94 Monofunctional C1- tetrahydrofolate synthase, Guanine nucleotidebinding protein G(s) subunit alpha isoforms short CCDC E MTHFD1L 3.50E GNAS 1.15E LVVPATQC GSLIGK LLGPTVML GGCEFSR EAENPREV LDQVCYRV EWAK NLANVR Q15365 Q8N9T8 Q ;Q15459 Q5T1W1;B7 ZBU3;Q5T1 V6-2;Q5T1V6;B 7ZBU4 Poly(rC)-binding protein 1 Protein KRI1 homolog Splicing factor 3A subunit 1 Probable ATPdependent RNA helicase DDX59 BP1 5.08E KRI1 2.47E SF3A1 3.27E DDX E SQSEGLKG EHGCR APPGGCEE RELALALQE ALEPAVR TSNKPLMII HHLDECPH SQALK Q6ZUK4 Q5RKV6 C9J3E2;B5 MC07;O Transmembrane protein 26 Exosome complex component MTR3 Anterior gradient protein 2 homolog TMEM E EXOSC6 1.34E AGR2 1.18E AEENKKEP LCR KCLEELQK R H3BUM8;H3 BRL3;O P49721;A0A 087WVV1 Ubiquitin domaincontaining protein UBFD1 Proteasome subunit beta type-2 UBFD1 4.34E PSMB2 9.92E S244

245 GGGGG GFQPASR YYTSASGD EMVSLKDY CTR AAAGELQE DSGLCVLA R KAPETCST AGRGPQVI AGGR TFCGTPEYL APEVLEDN DYGR YCSGTGWP SFSEAHGT SGSDESHT GILR VCENIPIVL CGNK Carbamidomet hyl (C);IAAyne Q96QR8 P07900;P H0Y4Y4;Q9 6C19 Q86VY4 M0R0P9;P ;Q9Y243-2;Q9Y243;P 31749;P317 51;A0A087 WY56;G3V3 X1;J3QKW1 Q9Y3D2 B4DV51;F5 H018;B5MD F5;J3KQE5; P62826 Transcriptional activator protein Pur-beta Heat shock protein HSP 90- alpha EF-hand domaincontaining protein D2 Testis-specific Y-encoded-like protein 5 RAC-alpha serine/threonineprotein kinase;racgamma serine/threonineprotein kinase;racbeta serine/threonineprotein kinase Methionine-Rsulfoxide reductase B2, GTP-binding nuclear protein Ran PURB 2.45E HSP90AA1 1.91E EFHD2 2.46E TSPYL5 1.37E AKT2;AKT1;A KT3 5.65E MSRB2 1.05E RAN 9.52E GTVLLADN VICPGAPDF LAHVR VVCSSGAV GNYSGGLA VK LDINLLDNV VNCLYHGE GAQQR P ;P21964 P16455 O14980;C9J 673;C9JKM 9;C9JF49;C 9IYM2;F8W F71;C9IZS4; C9JQ02;C9J V99 Catechol O- methyltransferas e COMT 6.03E Methylated- MGMT 2.40E DNA--proteincysteine methyltransferas e Exportin-1 XPO1 1.20E NAEDCLYE LPENIR VTYDSDAT SSACR CMPTFQFF K IEEACEIYA R A0A087X2F 5;Q9NZ63 A0A087X0N 2;O15243 P ;P10599 M0R0Y2;M0 R2M1;P Uncharacterized protein C9orf78 C9orf E Leptin receptor gene-related protein LEPROT 2.16E Thioredoxin TXN 5.64E Alpha-soluble NSF attachment protein NAPA 5.61E NSFYMGTC QDEPEQLD DWNR A0A087WY6 1;Q ;Q14980;Q ;H0YFY6 Nuclear mitotic apparatus protein 1 NUMA1 2.43E S245

246 YYGGAEVV DEIELLCQR R P ;P ;P34897;G 3V241;G3V3 Y8;G3V4T0; G3V4X0;G3 V2W0;G3V2 E4;G3V540; G3V5L0;G3 V4W5 Serine hydroxymethyltr ansferase, SHMT2 6.65E QICSCDGLT IWEER VDVFREDL CTKTENLLG SYFPK DILKEMFPY EASTPTGIS ASCR AKECEPPS AGAAVTAR PGQEIR Carbamidomet hyl (C);IAAyne J3KNF4;O Q ;Q06323;Q H0YJH7;G5 E972;P ;P42167 Q9C0E8-3;Q9C0E8-2;Q9C0E8;Q 9C0E8-4 Copper chaperone for superoxide dismutase CCS 8.26E Proteasome PSME1 1.96E activator complex subunit 1 Laminaassociated TMPO 1.39E polypeptide 2, isoforms beta/gamma;thy mopoietin;thym opentin Protein lunapark LNP 1.41E TSNKPLMII HHLDECPH SQALK Oxidation (M); C9J3E2;B5 MC07;O Anterior gradient protein 2 homolog AGR2 1.18E YIYDQCPAV AGYGPIEQL PDYNR YSRKPNVG CQQDSEEL LK CTKEEHLC TQR Carbamidomet hyl (C);IAAyne P31930 Cytochrome b- c1 complex subunit 1, A0AVT1-3;A0AVT1 Ubiquitin-like modifieractivating enzyme 6 Q5VU61;A0A087WWU8;Q5VU5 9;P ;J3KN67;P ;P UQCRC1 9.99E UBA6 3.43E TPM3 8.45E SWVCRK F2Z3C0;A8 MXK4;B5M CT8;C9JM1 9;P S ribosomal protein S9 RPS9 1.31E S246

247 ARQYPWGV VQVENENH CDFVK E7EW69;E7 EX04;B5ME 97;Q9P0V9; Q9P0V9-2;D6RDU5; D6RGI3;A0 A087X142;A 6NMH6;D6R ER5;A6NFQ 9;F8W8I8;Q ;Q9NVA2; Q ;Q9P0V9-3;Q9NVA2-2;Q ;Q92599 Septin- 10;Septin- 8;Septin-11 SEPT10;SEPT 11;SEPT8 2.28E CAPAPPPP PPPPTSGPI GGLR F5GXF5;Q ;Q ;Q12830 Nucleosomeremodeling factor subunit BPTF BPTF 7.88E DFTPVCTTE LGR SVLGGDCL LK AVQDLCGW R VKNQLKET TEAACR P30041 Peroxiredoxin-6 PRDX6 6.40E P41240 Tyrosine-protein CSK 3.66E kinase CSK Q9P258 Protein RCC2 RCC2 6.31E E9PFN5;Q9 Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3; Q9Y2Q3-2 Glutathione S- transferase kappa 1 GSTK1 1.49E IEPEPFENC LLRPGSPA R SGCALTDA VAPGNK P ;P48637 H3BMJ8;H3 BSP8;Q9BQ 70;H3BS87; Q9H7D3;H3 BTU3 Glutathione synthetase Transcription factor 25 GSS 3.67E TCF25;NULP1 2.67E TLETANCM SSQTK Oxidation (M); P ;P50416;H 3BP22;H3B UV7 Carnitine O- palmitoyltransfer ase 1, liver isoform CPT1A 4.64E ICPVETLVE EAIQCAEK WVDPNSPV LLEDPVLCA LAK Carbamidomet hyl (C);IAAyne P30084 S4R3Z2;A0 A0A0MSS8; P ;P42330 Enoyl-CoA hydratase, Aldo-keto reductase family 1 member C3 ECHS1 3.43E AKR1C3 2.54E ICFLSQEEN ELGK C9J8Y3;C9J 3Y4;B9ZVM 7;Q6LCR0;E 7ENI6;E9PD L4;Q ;Q05084;Q Islet cell autoantigen 1 ICA1 1.29E TYCCDLK Carbamidomet hyl (C);IAAyne Q9Y6C9 Mitochondrial carrier homolog 2 MTCH2 3.24E S247

248 GDFCIQVG R LTWHSCPE DEAQ GSENEDLW AESEGTVA CLGAEDR ILTFDQLAL DSPKGCGT VLLSGPR Q32Q12;O6 0361;P2239 2;P ;E7ERL0;J 3KPD9;P15 531;P Q13185 Q92968 F8VUA6;G3 V203;H0YH A7;J3QQ67; Q ;Q07020 Nucleoside diphosphate kinase;putative nucleoside diphosphate kinase;nucleosi de diphosphate kinase B;Nucleoside diphosphate kinase A Chromobox protein homolog 3 Peroxisomal membrane protein PEX13 60S ribosomal protein L18 NME1- NME2;NME2P 1;NME2;NME E CBX3 1.11E PEX E RPL E DRVVVVSH DENLCR NPPVGACD LQGELDRF GGISVR NVMVEPHR HEGVFICR Oxidation (M); Q7L5L3-1;Q7L5L3 E9PBZ9;P M0QXL5;M0 R2Q4;P220 87;M0R2U2; M0R1H0;M0 R2B0;M0R0 P1 Glycerophospho diester phosphodiestera se domaincontaining protein 3 Nucleoside diphosphatelinked moiety X motif 6 rrna 2'-Omethyltransferas e fibrillarin GDPD3 8.86E NUDT6 1.19E FBL 7.19E VWAVLPSS PEACGAAS LQER LICCDILDVL DK SKGDCQTL SEGSPGSS QSGSR ANNNAAVA PTTCPLQP VTDPFAFS R EGITGPPAD SSKPIGPDD AIDALSSDF TCGSPTAA GK Carbamidomet hyl (C);IAAyne Q5T440 P ;P62258;K 7EIT4 F8WEE6;O ;O94972 Putative transferase CAF17, protein epsilon E3 ubiquitinprotein ligase TRIM37 IBA E YWHAE 8.19E TRIM E F1T0I1;J3KNL6 SEC16A 2.27E E9PDE4;E7 ES10;E7EV Y3;B7Z574; P ;P ;P20810;P ;P ;P ;P ;H0YA91 Calpastatin CAST 4.86E KADVIVLAG TVCDFR M0R026;A1 L0T0;M0QZ X5 Acetolactate synthase-like protein ILVBL 6.75E GCIVDANLS VLNLVIVK P62753;A2A 3R5 40S ribosomal protein S6 RPS6 1.71E S248

249 YLCDFTYYT SLYQSHGR DWVIPPISC PENEKGPF PK Q9NXJ5-2;Q9NXJ5 J3QKP1;H3 BVI7;H3BN C6;A0A087 WX17;A0A0 87WU43;A0 A087WXI5;P ;P12830 Pyroglutamylpeptidase 1 Cadherin-1;E- Cad/CTF1;E- Cad/CTF2;E- Cad/CTF3 PGPEP1 4.67E CDH1 5.53E FQGIKHEC QANGPEDL NRACIAEK ELISLHIKED LCR Carbamidomet hyl (C);IAAyne P ;P60981 E9PG59;E9 PHC0;E9 Z3;D6RJC3; E7EQN9;O Destrin DSTN 1.85E Type II inositol 3,4- bisphosphate 4- phosphatase INPP4B 2.67E ECLPLIIFLR SGLDPTVT GC A6NH36;P S ribosomal protein S4, X isoform A0A096LPH4;A0A096LP96;A0A 096LPB7;A0A096LNN4;D3YTF8 RPS4X 1.74E TXNRD2 5.09E ICPNAPDP SYESSEDC SEAAGSPA RK Q8WUZ0 K7ER58;Q6 P6C2-3;Q6P6C2 B-cell CLL/lymphoma 7 protein family member C RNA demethylase ALKBH5 BCL7C 2.19E ALKBH5 3.60E YADLTEDQ LPSCESLKD TIAR EIDKCLSR SSGCDVNL PGVNVKLP TGQISGPEI K GFGFVTYS CVEEVDAA MCARPHKV DGR AGLHCTQA YPVR LSALCPK DSGTVSAL TWSLSSYT CATR REEGDPSP HSGGVCKP K Carbamidomet hyl (C);IAAyne P18669 Q14344 Q09666 P ;P51991 Q92585 Q14149 Q8N755 O ;O75376;J3 KRE4;E7EV K1 Phosphoglycerat e mutase 1 Guanine nucleotidebinding protein subunit alpha-13 Neuroblast differentiationassociated protein AHNAK Heterogeneous nuclear ribonucleoprotei n A3 Mastermind-like protein 1 MORC family CW-type zinc finger protein 3 PQ-loop repeatcontaining protein 3 Nuclear receptor corepressor 1 PGAM1 3.46E GNA E AHNAK 1.39E HNRNPA3 4.50E MAML1 9.87E MORC3 1.06E PQLC3 3.13E NCOR1 5.13E AWVWNTH ADFADECP KPELLAIR C9JXG8;C9 JJ34;C9JGV 6;F6WQW2; P ;P43487 Ran-specific GTPaseactivating protein RANBP1 1.98E S249

250 IIPDCNADN SK M0QYU7;M 0QXT0;B4D LJ1;Q ;Q ;Q ;Q15853 Upstream stimulatory factor 2 USF2 3.93E VDCDQHSD IAQR LDVGNFSW GSECCTRK AFQYVETH GEVCPANW TPDSPTIKP SPAASKEY FQK CAPSAGSP AAAVGR QAVDSPAA SFCR AETAANRIC K Carbamidomet hyl (C);IAAyne Q9BS26 P62241 P ;P30048 Q7L2J0 Q9H6R4-4;Q9H6R4 O ;O43707;H 9KV75;P ;P12814;P ;P ;K7EJH8;P ;G3V2W4; G3V2N5 Endoplasmic reticulum resident protein 44 40S ribosomal protein S8 Thioredoxindependent peroxide reductase, 7SK snrna methylphosphat e capping enzyme Nucleolar protein 6 Alpha-actinin- 4;Alpha-actinin- 1;Alpha-actinin-2 ERP E RPS8 1.90E PRDX3 1.54E MEE 5.36E NOL6 3.55E ACTN4;ACTN 1;ACTN2 4.90E CAAPRPPS SSPEQR H0YEN2;E9 PQP7;H7BX H2;E9PKF6; Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7; Q5H9R7-5 Serine/threonine -protein phosphatase 6 regulatory subunit 3 PPP6R3 6.56E YGIICMEDLI HEIYTVGKR MCPATQK EEFASTCP DDEEIELAY EQVAK FKCEKQPG AGGGGGS GSGGSGAK LSKHCSQV DSVR Oxidation (M); A8MUD9;P Q9H307-2;Q9H307 O00299 P ;P55317 Q ;Q14247;Q ;H7C314 60S ribosomal protein L7 RPL7 3.02E Pinin PNN 8.32E Chloride intracellular channel protein 1 Hepatocyte nuclear factor 3- alpha Src substrate cortactin CLIC1 5.51E FOXA1 3.43E CTTN 4.63E EAQDAPGL DPQGAADC AQGVLR P ;P ;P ;P ;P39880;P Homeobox protein cut-like 1 CUX1 4.90E S250

251 GTGELTQLL NSLCTAVK ASGPDGEC DSNGPGFY LYDLGSTH GTFLNK FCPFAER P09467 A0A087X0M 4;Q9BWU0 Q5TA01;Q5 TA02;P ;P ;P78417 Fructose-1,6- bisphosphatase 1 FBP1 0.00E Kanadaptin SLC4A1AP 1.54E Glutathione S- transferase omega-1 GSTO1 7.16E YGINTTDIF QTVDLWEG KNMACVQR X6RJP6;P37 802;P Transgelin-2 TAGLN2 1.44E IVADQLCAK H3BQF7;H3 BMU1;H3BU I0;J3KR23;P ;P ;P53990;P ;P IST1 homolog IST1 5.62E CDSADLRH DIDRR E9PK09;E9 PQN2;E9PK I6;E9PK91; Q9NYF8-4;Q9NYF8-3;Q9NYF8-2;Q9NYF8 Bcl-2-associated transcription factor 1 BCLAF1 1.24E CTPGTGLG TSPALAGD EAASAADL DNRFR CPIQLNEGV SFQDLDTA K RPGCFLCR EEAADLSSL K NIELICQEN EGENDPVL QR LLMEQESS ACSRR LALFNPDVC WDRNNPEP WNK LLCGLLAER NSNVDSSY LESLYQSC PR Carbamidomet hyl (C);IAAyne Oxidation (M); P35568 A6NDU8 Q9BRX8-2;Q9BRX8 Q15691 O ;O96011 O00483 P14174 C9J6P4;Q7 Z2W4-2;Q7Z2W4; H7C5K1;Q7 Z2W4-5;Q7Z2W4-4 Insulin receptor substrate 1 UPF0600 protein C5orf51 Redoxregulatory protein FAM213A Microtubuleassociated protein RP/EB family member 1 Peroxisomal membrane protein 11B Cytochrome c oxidase subunit NDUFA4 Macrophage migration inhibitory factor Zinc finger CCCH-type antiviral protein 1 IRS1 2.99E C5orf E FAM213A 8.45E MAPRE1 3.37E PEX11B 7.18E NDUFA4 6.11E MIF 1.10E ZC3HAV1 9.81E YQIDPDACF SAK P21796 Voltagedependent anion-selective channel protein 1 VDAC1 3.39E S251

252 RQLCGGNQ AATER R4GMX8;Q6 VN20-2;Q6VN20-3;Q6VN20 Ran-binding protein 10 RANBP E GTPEQPQC GFSNAVVQI LR TYAICGAIR R Q86SX6 Q8WVC2;Q 9BYK1;P Glutaredoxinrelated protein 5, 40S ribosomal protein S21 GLRX5 2.12E RPS E RGSDELFS TCVTNGPFI MSSNSASA ANGNDSKK Oxidation (M); P26599;P ;P ;K7EKX4;K 7EKJ7 Polypyrimidine tract-binding protein 1 PTBP1 9.89E TTEEQVQA STPR TVCDAAEK GVR Q14137 K7ER39;K7 EL96;O ;O ;O60664 Ribosome biogenesis protein BOP1 BOP1 1.54E Perilipin-3 PLIN3 1.40E VGVGTCGI ADKPMTQY QDTSKYNV R TEASKLVM SYVAAVCG K O75940 C9JUP5;C9 JYW1;E7EQ D9;E9PDF6; Q9UBC5;O ;O43795 Survival of motor neuron-relatedsplicing factor 30 Unconventional myosin- Ia;Unconvention al myosin-ib SMNDC1 8.57E MYO1B;MYO1 A 2.05E AGAIAEV TVPAQNTG LGPEK F8VQY6;F8 VRK7;G3V2 10;F8VU65; F8VWS0;P ;Q8NHW5; P05388;F8V PE8;F8VW2 1 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like RPLP0;RPLP0 P6 5.09E LTTLPSDFC GLTHLVK TKSCSGVE FSTSGHAY TDTGK QIGIDPPRG VLMYGPPG CGK ASEDGESV GHCPSCQR Carbamidomet hyl (C);IAAyne Q96AG4 Q9Y277;E5 RHE1;E5RJ N6;E5RHZ6 P ;P43686 O95833 Leucine-rich repeatcontaining protein 59 Voltagedependent anion-selective channel protein 3 26S protease regulatory subunit 6B Chloride intracellular channel protein 3 LRRC E VDAC3 2.12E PSMC4 7.91E CLIC3 7.16E S252

253 AVFPEG EEPLQLRK F5GWN4;F8 WBT0;A0A0 A0MSJ2;E7 EU13;Q96P 48-5;Q96P48-7;Q96P48-2;Q96P48-4;Q96P48-1;Q96P48-3;Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domaincontaining protein 1 ARAP1 1.99E TGQYSGIY DCAK VLVQHCPA R Q6NUK1-2;Q6NUK1 I3VM54;Q9Y 2K7-4;Q9Y2K7-5;Q9Y2K7-2;Q9Y2K7 Calcium-binding carrier protein SCaMC-1 Lysine-specific demethylase 2A SLC25A E KDM2A 3.47E SLLNQCIEE R VNDSERNP NLSCKR Q96GM8 E9PQ42;E9 PJD7;Q6ZM K1-2;Q6ZMK1 Target of EGR1 protein 1 Cysteine and histidine-rich protein 1 TOE1 5.22E CYHR1 7.74E QYPWGVAE VENGEHCD FTILR H0Y3Y4;G3 V1Q4;E7ES 33;E7EPK1; Q ;Q16181 Septin-7 SEPT7 1.67E LVIVGDGAC GK E9PQH6;Q5 JR08;P0813 4;E9PLA2;C 9J1T2;C9JR M1;Q5JR06; Q5JR07;E9 PN11;C9JN R4;C9JX21; Q5JR05;U3 KQA9;U3KQ V3;P61586 Rho-related GTP-binding protein RhoC;Transform ing protein RhoA RHOC;RHOA 4.41E TCFSMVPA LQQELDSR PQLR IGFPETTEE ELEEIASEN SDCIFPSAP DVKA LQEALDAE MLEDEAGG GGAGPGGA CK GVLMYGPP GCGK FVVDVDKNI DINDVTPNC R K7ENV7;K7 EKW4;Q96A B3;Q96AB3-2 Q9Y3F4;Q9 Y3F4-2 H3BQZ7;Q1 KMD3 P ;P43686 J3QRW1;J3 QLH6;J3KR P2;J3QSA9; P ;P62195 ISOC2 4.86E STRAP 2.21E Isochorismatase domaincontaining protein 2, Serine-threonine kinase receptorassociated protein Heterogeneous nuclear ribonucleoprotei n U-like protein 2 26S protease regulatory subunit 6B 26S protease regulatory subunit 8 HNRNPUL2- BSCL2;HNRN PUL2 4.04E PSMC4 1.23E PSMC5 2.42E S253

254 NCSSFLIKR H0YLP6;H0 YMF4;H0YK D8;P ;P ;P46779;P ;P S ribosomal protein L28 RPL E RAPPGGCE ERELALALQ EALEPAVR LLLCGGAPL SATTQR KLMEECKR IKESLPIDID QLSGRDFC HSK Q5RKV6 O95573 Q9P0L0;Q9 P0L0-2 Exosome complex component MTR3 Long-chain-fattyacid--CoA ligase 3 Vesicleassociated membrane proteinassociated protein A Oxidation resistance protein 1 Q8N573-3;Q8N573-2;Q8N573-5;Q8N573-8;Q8N573 EXOSC6 4.18E ACSL3 2.47E VAPA 6.10E OXR1 3.37E KVEEVTKV CEGR LFNTAVCES KDLSDTVR IIPGFMCQG GDFTR IAVYSCPFD GMITETK Oxidation (M); M0QXN5;P Q9BXJ9 P62937;F8 WE65;C9J5 S7;A0A075B 767;A0A075 B759;Q9Y53 6;F5H284 P ;P50990;P Nuclear pore glycoprotein p62 N-alphaacetyltransferas e 15, NatA auxiliary subunit Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N- terminally processed;pepti dyl-prolyl cistrans isomerase;pepti dyl-prolyl cistrans isomerase A-like 4A/B/C;Peptidylprolyl cis-trans isomerase A-like 4D T-complex protein 1 subunit theta NUP E NAA E PPIA;PPIAL4F ;PPIAL4A;PPI AL4D 1.36E CCT8 4.40E GPAPAPQQ CSEPETK B1AMX5;G3 V154;Q3YE C7;Q3YEC7-2 Rab-like protein 6 RABL6 2.23E GSAITGPVA KECADLWP R AVCMLSNT TAIAEAWAR Oxidation (M); P62829;J3K TJ3 P ;P ;P68366;P S ribosomal protein L23 Tubulin alpha- 1B chain;tubulin alpha-4a chain RPL E TUBA1B;TUB A4A 2.71E VATFHDCE DAARELQS QIQEAR LTALDYHNP AGFNCKDE TEFR Q9P2X0;Q9 P2X0-2 G3V4E7;G3 V4C6;Q9Y2 24 Dolicholphosphate mannosyltransfe rase subunit 3 UPF0568 protein C14orf166 DPM3 8.27E C14orf E S254

255 IDRYTQQG FGNLPICMA K VFANPEDC VAFGKGEN AKK Oxidation (M); A0A087WV M4;B7ZM99; Q6UB35;Q4 VXM0 F5H7F6;F5 H6X2;P ;P10620 Monofunctional C1- tetrahydrofolate synthase, Microsomal glutathione S- transferase 1 MTHFD1L 3.50E MGST1 5.18E IKSGEEDFE SLASQFSD CSSAK CEFQDAYV LLSEK VLPSCDLA RR IECEIKINHE GEVNR K7EN45;K7 EMU7;Q P10809 Q96LJ7 Q5JP01;E9 52;Q165 76;Q Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 60 kda heat shock protein, Dehydrogenase/ reductase SDR family member 1 Histone-binding protein RBBP7 PIN1 3.27E HSPD1 1.09E DHRS1 4.83E RBBP7 5.63E CTGGEVGA TSALAPK QACEDELR ER P ;P30050 H3BP71;O ;O75150;H 3BQ99;H3B UL6;I3L332; O S ribosomal protein L12 E3 ubiquitinprotein ligase BRE1B RPL E RNF E NGQVCFST QDHKNP R Carbamidomet hyl (C);IAAyne B8ZZF0;C9J IR6;O ;O ;O ;O75688 Protein phosphatase 1B PPM1B 2.21E AVVVCPKD EDYKQR VPADTEVV CAPPTAYID FAR TDFQQGCA K DILKEMFPY EASTPTGIS ASCR YAICSALAA SALPALVM SK Oxidation (M); Q ;Q00839 P ;P60174 M0QXB5;O H0YJH7;G5 E972;P ;P42167 P36578;H3B M89;H3BTP 7 Heterogeneous nuclear ribonucleoprotei n U Triosephosphate isomerase Persulfide dioxygenase ETHE1, Laminaassociated polypeptide 2, isoforms beta/gamma;thy mopoietin;thym opentin 60S ribosomal protein L4 HNRNPU 1.05E TPI1 4.24E ETHE1 5.33E TMPO 1.39E RPL4 1.89E CAGNEDIIT LR LLYAATADD SSSSTSSD SLGGGYCG AR ATDYGPEE VCER SNLQEIFLP AFHER P12004 P35568 O ;O75157 Q9NPG8 Proliferating cell nuclear antigen Insulin receptor substrate 1 TSC22 domain family protein 2 Probable palmitoyltransfer ase ZDHHC4 NA 4.32E IRS1 5.19E TSC22D2 3.04E ZDHHC4 8.16E S255

256 SYCAEIAHN VSSK D3YTB1;F8 W727;P S ribosomal protein L32 RPL E RCQYVTEK P04075;P ;H3BPS8;H 3BQN4;J3K PS3;P09972 Fructosebisphosphate aldolase A;Fructosebisphosphate aldolase C ALDOA;ALDO C 6.26E MREIVHLQA GQCGNQIG AK P04350;P68 371;M0R2D 3;M0R0X0; M0R2T4;M0 QY85;M0QY 37;M0QX14; M0R042;M0 QYM7 Tubulin beta-4a chain;tubulin beta-4b chain TUBB4A;TUB B4B 3.77E ALVDGT QVRR LKSYCNDQ STGDIKVIG GDDLSTLT GK DGTSLWDL LSSCHFTEE QRR E7EPB3;P P00492 A0A075B73 0;A0A087X1 U6;P S ribosomal protein L14 RPL E Hypoxanthineguanine phosphoribosyltr ansferase HPRT1 1.33E Epiplakin EPPK1 1.26E TAVCDIPPR GLK VAQATCKL P04350;P68 371;Q5ST81 ;Q5JP53;P0 7437;Q9BV A1;Q13885;I 3L2F9;A6N NZ2;A0A075 B736;Q5SQ Y0;Q3ZCM7 H0Y2L7;P ;P ;P35914 Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta chain;tubulin beta-2b chain;tubulin beta-2a chain;tubulin beta-8 chain-like protein LOC260334;Tub ulin beta-8 chain Hydroxymethylgl utaryl-coa lyase, TUBB4A;TUB B4B;TUBB;TU BB2B;TUBB2 A;TUBB8 1.43E HMGCL 3.74E SPSSQETH DSPFCLRK GLDYEGGG CR LLQFYAETC PAPER Q8TB45-2;Q8TB45 H7C2S8;O F5H6E2;O ;O ;O00159;I3 L168;I3L3F5 ;I3L4D4;I3L5 01;I3L3Y6;I3 L204 DEP domaincontaining mtorinteracting protein Procollagen- lysine,2- oxoglutarate 5- dioxygenase 3 Unconventional myosin-ic DEPTOR 4.55E PLOD3 2.57E MYO1C 2.20E TGAESISLL ELCR VGLTNYAA AYCTGLLLA R O60216;E5 RG18;E5RI0 1;E5RFZ5 Q5T7N0;P Double-strandbreak repair protein rad21 homolog 60S ribosomal protein L5 RAD E RPL5 9.71E S256

257 GYEVIYLTE PVDEYCIQA LPEFDGKR CIYEIFSK KYTELPHG AISEDQAVG PADIDST GQTST VVLLGEGC VGK GATRPNGP NTGNKICQF K P14625 Endoplasmin HSP90B1 5.40E B4E127;G8J L98;Q13569 ;F5H0I7 H3BPN2;H3 BSA6;Q9H7 73 Q9UL25 F8WCY6;F8 WD79;P ;P20339 G/T mismatchspecific thymine DNA glycosylase dctp pyrophosphatas e 1 Ras-related protein Rab-21 Ras-related protein Rab-5A TDG 3.05E DCTPP1 2.82E RAB E RAB5A 3.07E ELQICPATA GSGPAATQ DFSK YVEPIEDVP CGNIVGLV GVDQFLVK ATLQAALCL ENFSSQVV ER P00519;P P13639 F8WDW3;F 8WE39;F8W DD7;H7C0A 3;F8WCF6; P59998;P ;P Tyrosine-protein kinase ABL1 Elongation factor 2 Actin-related protein 2/3 complex subunit 4 ABL1 1.04E EEF2 2.62E AR4;AR 4-TTLL3 3.99E LIIAGTSCYS R P ;P34896;P ;P Serine hydroxymethyltr ansferase, cytosolic SHMT1 2.38E YASICQQN GIVPIVEPEI LPDGDHDL KR INDALSCEY ECR QQLPQTPP SCLK SQETECTY FSTPLLLGK K NSSDLGCK EGADKR ESCGSSVL TDFEGKDV ATK Carbamidomet hyl (C);IAAyne P04075;P ;H3BPS8;H 3BQN4;P Q52LJ0;Q52 LJ0-2 Q8IY81 P ;P40926;G 3XAL0 Q9NV56 H0Y704;O ;O ;O ;O15231;O ;O ;O ;H7BZT5;O ;O Fructosebisphosphate aldolase A;Fructosebisphosphate aldolase C ALDOA;ALDO C 1.02E Protein FAM98B FAM98B 2.00E pre-rrna processing protein FTSJ3 Malate dehydrogenase, ;M alate dehydrogenase MRG/MORF4Lbinding protein Zinc finger protein 185 FTSJ3 3.42E MDH2 8.26E MRGBP 7.86E ZNF E EIDCLSPEA QK Q32MZ4-3;Q32MZ4-2;Q32MZ4;C 9JTC6 Leucine-rich repeat flightlessinteracting protein 1 LRRFIP1 3.38E S257

258 FMADCPHTI GVEFGTR AATGEEVS AEDLGGAD LHCRK ICPVEFNPN FVAR ALFDYNPN EDKAIKE AGLSFK X6RFL8;P D6RD67;D6 R9R1;D6RD F7;Q9HCC0-2;Q9HCC0 F5GX77;Q9 UI30-2;Q9UI30 S4R337;Q5 T2T1-2;Q5T2T1 Ras-related protein Rab-14 Methylcrotonoyl- CoA carboxylase beta chain, Multifunctional methyltransferas e subunit TRM112-like protein MAGUK p55 subfamily member 7 RAB E MCCC2 6.01E TRMT E MPP7 7.46E VWNLANCK H0Y8R5;D6 RBD0;D6RF X4;D6RHH4 ;D6R9Z1;H0 YAM7;D6RA C2;J3KPE3; H0Y8W2;D6 R9L0;D6RE E5;P63244 Guanine nucleotidebinding protein subunit beta-2- like 1;Guanine nucleotidebinding protein subunit beta-2- like 1, N- terminally processed GNB2L1 1.79E ALANVNIGS LICNVGAG GPAPAAGA APAGGPAP STAAAPAE EK LILDVFCGS QMHFVR Oxidation (M); P05386 P11413;P ;P S acidic ribosomal protein P1 Glucose-6- phosphate 1- dehydrogenase RPLP1 8.50E G6PD 1.53E LVVPASQC GSLIGKGG CK Carbamidomet hyl (C);IAAyne F8VXH9;H3 BRU6;F8VZ X2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;F8W0G4;F 8W1G6;H3B ND9 Poly(rC)-binding protein 2 BP2 2.95E GSQMGTVQ PILLSMP TR Q9NZB2;Q9 NZB2-6;Q9NZB2-2;Q9NZB2-5;Q9NZB2-4 Constitutive coactivator of PPAR-gammalike protein 1 FAM120A 6.39E IACDEEFSD SEDEGEGG RR VFANPEDC VAFGKGEN AK Q ;Q92769 F5H7F6;F5 H6X2;P ;P10620 Histone deacetylase 2 Microsomal glutathione S- transferase 1 HDAC2 1.66E MGST1 8.58E TQSFGD DDPAKKEP R Q ;Q12765;Q Secernin-1 SCRN1 1.13E AIEIDEQQG CKEQER Q9NVK5-2;Q9NVK5 FGFR1 oncogene partner 2 FGFR1OP2 2.88E S258

259 QMEKDETV SDCSPHIAN IGR B1AK87;B1 AK85;B1AK 88;P ;P47756 F-actin-capping protein subunit beta CAPZB 3.84E SDVCTPGG TTIYGLHAL EQGGLR B5MD87;A0 A0A0MQS1; Q53H96-2;Q53H96 Pyrroline-5- carboxylate reductase 3 PYCRL 1.88E LCTSATESE VAR EGTDSSQG IPQLVSNIS ACQVIAEAV R AAREECPV FTPPGGET LDQVK LKSYCNDQ STGDIK CALRDAR P31930 Cytochrome b- c1 complex subunit 1, F8WBP8;Q Q9NQ88 P00492 A0A075B73 0;A0A087X1 U6;P58107 T-complex protein 1 subunit eta UQCRC1 5.19E CCT7 2.83E Fructose-2,6- bisphosphatase TIGAR TIGAR 1.11E Hypoxanthineguanine HPRT1 6.55E phosphoribosyltr ansferase Epiplakin EPPK1 1.29E VNQIGSVTE SLQACK GCGVVKFE SPEVAER LQGINCGP DFTPSFANL GR P ;P06733 A0A087X0X 3;P ;P52272 C9J6B6;C9J 2Z7;C9K073 ;C9JF13;A0 A0A0MR52; E7EX73;E9 PGM1;E7EU U4;Q ;Q ;Q ;Q ;Q ;Q04637;Q ;Q Alpha-enolase ENO1 1.04E Heterogeneous nuclear ribonucleoprotei n M Eukaryotic translation initiation factor 4 gamma 1 HNRNPM 1.55E EIF4G1 4.15E GIFPVLCKD PVQEAWAE DVDLR B4DNK4;P1 4618;P ;P ;H3BR70 Pyruvate kinase;pyruvate kinase PKM PKM 3.26E QAVLGAGL PISTTTIN KVCASGMK QLFALSCTA EEQGVLPD DLSGVIRR Carbamidomet hyl (C);Oxidation (M); P24752;E9P KF3;H0YEL 7;P P ;P ;P ;P ;P04899;P Acetyl-CoA acetyltransferas e, Guanine nucleotidebinding protein G(i) subunit alpha-2 ACAT1 7.45E GNAI2 2.42E DICNDVLSL LEK E7ESK7;E7 EX29;P6310 4;B0AZS protein zeta/delta YWHAZ 6.67E SVVCQESD LPDELLYGR Q9NS86 LanC-like protein 2 LANCL2 1.69E S259

260 LCDFGISGQ LVDSIAK LCYVALDFE QEMATAAS SSSLEK VRNCSSPE FSK P45985;P P60709;P63 261;Q6S8J3 ;I3L4N8 Q5JX53;Q5J X54;Q5JX57 ;E7EV27;Q5 JX55;Q5JX5 6;Q5JX58;Q 5JX59;Q5JX 61;Q5JX60; Q5JX44;Q5J X52;Q5JX45 ;E7ENH5;A6 PVH9;F2Z2 V0;B0QZ18; Q99829 Dual specificity mitogenactivated protein kinase kinase 4 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;pot E ankyrin domain family member E MAP2K4 7.61E ACTB;ACTG1; POTEE 5.22E Copine-1 CPNE1 1.16E TCPFCSK ALGKHPVS CK Carbamidomet hyl (C);IAAyne Q9H7Z7 E9PF18;A0 A0A0MSE2; Q16836;Q ;Q Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form Hydroxyacylcoenzyme A dehydrogenase, PTGES2 2.40E HADH 1.42E AIAESLNSC RPSDASAT R D6RC40;D6 RCQ3;Q96R L1-2;Q96RL1-3;Q96RL1 BRCA1-A complex subunit RAP80 UIMC1 6.85E AAAPAPEE EMDECEQA LAAEPK DLFEGRPP MEQPGV GK P26641;P A0A087X1L 5;Q15170;Q Elongation factor 1-gamma Transcription elongation factor A protein-like 1 EEF1G 1.09E TCEAL1 1.51E GAVEKGEE LSCEER YGQNCHKG PPHSK SDLGEKI HDENLR P31947;P O15355 D6RDI2;J3K PP4;O protein sigma Protein phosphatase 1G Luc7-like protein 3 SFN 1.59E PPM1G 4.90E LUC7L3 3.91E S260

261 GLPWSCSA DEVQR E9Y7;G8 JLB6;P3194 3;D6RIT2;D 6RF17;D6R DL0;E7EQJ 0;D6RAM1; D6R9T0;D6 RFM3;E7EN 40;D6RIU0; D6RDU3;D6 RJ04;D6RIH 9;D6RBM0; D6R9D3;E5 RGV0 Heterogeneous nuclear ribonucleoprotei n H;Heterogeneou s nuclear ribonucleoprotei n H, N-terminally processed HNRNPH1 2.00E YVAAAFPS ACGK A0A0A0MS7 4;H0YML5;B 4DW73;H0Y M31;Q ;Q16822 Phosphoenolpyr uvate carboxykinase [GTP], K2 3.33E TQEQCVHN ETKNELEK VGEEFEEQ TVDGRK GRQYPWG VAEVENGE HCDFTILR E5KLK1;E5 KLJ6;E5KLJ 9;E5KLJ5;O 60313;O P29373 H0Y3Y4;G3 V1Q4;E7ES 33;E7EPK1; Q ;Q16181 Dynamin-like 120 kda protein, ;Dy namin-like 120 kda protein, form S1 OPA1 2.87E Cellular retinoic CRABP2 8.13E acid-binding protein 2 Septin-7 SEPT7 2.59E LGELQGEA ASREDTICL LQNEK Q ;Q ;Q08378 Golgin subfamily A member 3 GOLGA3 1.09E LQFHDVAG DIFHQQCK P11413;P ;P Glucose-6- phosphate 1- dehydrogenase G6PD 7.69E AGSDGESI GNCPFSQR LFACSNK Q9Y696 Q5T0H7;Q5 T0H8;Q5T0 H9;A0A0A0 MS51;A0A0 A0MT01;CO N Q3SX14 ;P ;P ;P ;P06396 Chloride intracellular channel protein 4 CLIC4 6.88E Gelsolin GSN 1.72E CGASFYVN R O ;H0Y742;O SUN1 3.99E KSYESSED CSEAAGSP AR K7ER58;Q6 P6C2-3;Q6P6C2 RNA demethylase ALKBH5 ALKBH5 3.60E S261

262 QKLTAEFEE AQTSACR F8W7S5;A0 A087WVV2; A0A0A0MR V0;Q9P2E9-3;Q9P2E9-2;Q9P2E9;A 0A087WU26 Ribosomebinding protein 1 RRBP1 3.69E YKVCNYGL TFTQK Q9Y277;E5 RHE1;E5RJ N6;E5RHZ6; Q9Y277-2;E5RK27;E 5RFP6 Voltagedependent anion-selective channel protein 3 VDAC3 4.01E VTQQVNPIF SEAC H0YMB3;H0 YLV5;A0A08 7WWM4;F8 WAN9;H0Y NJ6;Q9P2T 1-3;Q9P2T1;Q 9P2T1-2;H0YN22;H 0YK13 GMP reductase;gmp reductase 2 GMPR2 1.93E RSEKPPAG SICR FACFER P56182 F8VVM2;Q ;Q00325 Ribosomal RNA processing protein 1 homolog A Phosphate carrier protein, RRP1 3.14E SLC25A3 5.97E SDITKLEVD AIVNAANSS LLGGGGVD GCIHR LLMEQESS ACSRR EACSYTIHA EGDERGTK Q9BQ69 O ;O96011 H0YGC7;F5 H362;F5H75 5;F5H5A1;Q 4G176 O-acetyl-ADPribose deacetylase MACROD1 Peroxisomal membrane protein 11B Acyl-CoA synthetase family member 3, MACROD1 5.58E PEX11B 7.18E ACSF3 2.53E LTEEETVCL DLDKVEAY R P ;P ;P15924 Desmoplakin DSP 3.97E VMAEANHFI DLSQING K CTSGGYYR YDDMLVVPI IENTPEEK Oxidation (M); O ;O ;O ;O15294 S4R3D6;Q9 6GX9-3;Q96GX9 UDP-Nacetylglucosami ne--peptide N- acetylglucosami nyltransferase 110 kda subunit Methylthioribulos e-1-phosphate dehydratase OGT 2.08E APIP 1.24E YATSCYSC CPR KTYITDPVS AAPPLQ PK 2 Carbamidomet hyl (C);IAAyne K7E2;K7 ES73;K7EN 91;Q13057; Q C9JXK9;C9J UT4;A0A087 WZF1;Q Bifunctional coenzyme A synthase;phosp hopantetheine adenylyltransfer ase;dephospho- CoA kinase Lipomapreferred partner COASY 1.34E LPP 3.69E S262

263 MLPDKDCR G3V1A4;E9 PP50;E9PK 25;P23528; E9PLJ3;E9P S23;E9PQB 7 Cofilin-1 CFL1 2.46E MKVACITEQ VLTLVNKR AATGEEVS AEDLGGAD LHCR VIVKCPTSG R B7Z4L4;P D6RD67;D6 R9R1;D6RD F7;Q9HCC0-2;Q9HCC0 C9JBE1;E7 EMB6;E7ET B3;Q9ULA0; C9JRG3;C9 J1E2;E7EP X3;B9ZVU2; F8WAN0 Dolichyldiphosphooligos accharide-- protein glycosyltransfera se subunit 1 Methylcrotonoyl- CoA carboxylase beta chain, Aspartyl aminopeptidase RPN1 1.18E MCCC2 2.23E DNPEP 2.67E RLDECEEA FQGTK K7EMD0;K7 EPX6;K7EK R3;K7ENH2; B3KQ25;K7 ESG5;K9J9 57;P61289; P ;P Proteasome activator complex subunit 3 PSME3 7.09E EAIEGTYID KKCPFTGN VSIR DQGSCGSC WAFGAVEA ISDR Carbamidomet hyl (C);IAAyne P62280;M0 QZC5 P07858;E9P KQ7;E9PNL 5;E9PHZ5;E 9PLY3;E9P SG5;E9PQ M1 40S ribosomal protein S11 Cathepsin B;Cathepsin B light chain;cathepsin B heavy chain RPS E CTSB 1.15E VICAEEPYI CKDFPETN NILK CSTPEEIKK AVELLGDIV QNCSLEDS QIEKER AYCHILLGN YCVAVADA KK VGIGPGSV CTTR Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne P ;P49915 GMP synthase [glutaminehydrolyzing] P ;P60981;F6 RFD5 P31930 Cytochrome b- c1 complex subunit 1, Q9Y2Z0-2;Q9Y2Z0 H0YMB3;H0 YLV5;A0A08 7WWM4;F8 WAN9;H0Y NJ6;Q9P2T 1-3;Q9P2T1;Q 9P2T1-2;H0YNS9;H 0YLB8;H0Y NH0 GMPS 1.33E Destrin DSTN 5.46E Suppressor of G2 allele of SKP1 homolog GMP reductase;gmp reductase 2 UQCRC1 7.75E SUGT1 5.06E GMPR2 2.70E S263

264 VAYDKT ALALEVGDI VK ELVNAQCA K AIGAVPLIQ GEYMIE K TRPDGNCF YR P46109 Crk-like protein CRKL 3.79E I3L2J1;Q9Y 3C7 H7C1V0;H7 C469;P J3KR44;F5H 6Q1;F5GYJ 8;Q96FW1;F 5GYN4 Mediator of RNA polymerase II transcription subunit 31 Cathepsin D;Cathepsin D light chain;cathepsin D heavy chain Ubiquitin thioesterase OTUB1 MED E CTSD 2.46E OTUB1 1.18E KNEPPLTC PYSLK LIPDGCGVK Q9UGP8 X1WI28;P27 635;F8W7C 6;A0A087W V22 Translocation protein SEC63 homolog 60S ribosomal protein L10 SEC E RPL E IKNCLNPQF SK E5RFT7;A0 A087WUS8; A0A087WX R6;E5RHZ0; A0A087WY Q3;O75131 Copine-3 CPNE3 2.64E LTDCVVMR DPASKR AKCELSSS VQTDINLPY LTMDSSGP K VTDDLVCLV YKTDQAQD VK ETQAQACP QEGTEAHG AR AGGIETIAN EYSDRCTP ACISFGPK Carbamidomet hyl (C);IAAyne A0A087WUI 2;P ;P22626 H0YBG6;P P49458 Q8N3D4;E9 PIH6 A0A087WT S8;A0A087 WYC1;P ;P34932 Heterogeneous nuclear ribonucleoprotei ns A2/B1 Stress-70 protein, Signal recognition particle 9 kda protein EH domainbinding protein 1-like protein 1 Heat shock 70 kda protein 4 HNRNPA2B1 7.03E HSPA9 1.96E SRP9 6.70E EHBP1L1 1.64E HSPA4 2.55E CSTPEEIKK R P ;P60981;F6 RFD5 Destrin DSTN 6.01E ENSQLDTS PLGGNK K EGLASATK DCSHREEK Q9Y3E2 A0A087X05 5;Q ;Q ;Q ;Q92766;Q BolA-like protein 1 Ras-responsive element-binding protein 1 BOLA1 2.27E RREB1 3.79E S264

265 REIVHLQAG QCGNQIGA K P04350;P68 371;M0R2D 3;M0R0X0; M0R2T4;M0 QY85;M0QY 37;M0QX14; M0R042;M0 QYM7 Tubulin beta-4a chain;tubulin beta-4b chain TUBB4A;TUB B4B 1.14E TYDPSGDS TLPTCSKK SGSRKPAF TEASCPLS R Q9Y2X3 O ;O15357;A 0A0A0MTP6 Nucleolar protein 58 Phosphatidylino sitol 3,4,5- trisphosphate 5- phosphatase 2 NOP E INPPL1 1.10E QLAQKYNC DK GLIAAICAG PTALLAHEI GFGSK M0R1M6;M0 R2S1;P K7EN27;K7 ELW0;Q Ubiquitin-60S ribosomal protein L40;Ubiquitin;60 S ribosomal protein L40 UBA E Protein DJ-1 PARK7 9.03E LITIEINPDC AAITQR P ;P21964;E 7EMS6;F8W BW9;E7EU U8 Catechol O- methyltransferas e COMT 5.08E AVLLASDA QECTLEEV VER CVFELPAE NDKPHDVEI NK KAAAPAPE EEMDECEQ ALAAEPK KIDVTEA EIISLGLPFG K Q27J81-2;Q27J81 O95292 P26641;P Vesicleassociated membrane proteinassociated protein B/C Elongation factor 1-gamma O ;O ;O ;O95758;O ;O ;X6R242 Inverted formin- 2 Polypyrimidine tract-binding protein 3 INF2 0.00E VAPB 5.05E EEF1G 3.27E PTBP3 3.06E YSLDPENP TKSCK A0A087WX M6;J3QQT2; J3KRX5;P18 621;P ;A0A087W Y81;J3KRB3 ;A0A087WW H0;J3QS96; J3KSJ0 60S ribosomal protein L17 RPL E LASGEHIAA FCLTEPAS GSDAASIR Q9H845 Acyl-CoA dehydrogenase family member 9, ACAD9 1.74E S265

266 SKGFGFVC FSSPEEATK A0A087WTT 1;E7EQV3;P ;P11940;H 0Y5F5;B1A NR0;Q ;Q13310;Q ;H0YB86;H 0YEU6;H0Y AR2;E7ERJ 7;Q9H361 Polyadenylatebinding protein 1;Polyadenylatebinding protein 4;Polyadenylatebinding protein 3 PAB1;PAB 4;PAB3 1.11E AKCELSSS VQTDINLPY LTMDSSGP K FSSSDFSDL SNGEELQE TCSSSLR Oxidation (M); H0YBG6;P H7C1G8;H7 C4B4;E9PH V6;P ;P ;P ;P ;P23497;P Stress-70 protein, Nuclear autoantigen Sp- 100 HSPA9 1.96E SP E VMAEANHFI DLSQING K AQNTWGC GNSLR Oxidation (M); O ;O ;O ;O15294 Q5TCI8;P ;P ;P ;P ;P ;P02545 UDP-Nacetylglucosami ne--peptide N- acetylglucosami nyltransferase 110 kda subunit Prelamin- A/C;Lamin-A/C OGT 2.08E LMNA 6.99E AIVLFTSDA CGLSDVAH VESLQEK P ;P ;P24468 COUP transcription factor 2 NR2F2 0.00E FQYQLACR Q96SK2-3;Q96SK2-2;Q96SK2 Transmembrane protein 209 TMEM E LLACIASRP GQCGR VLGLGLGC LR Carbamidomet hyl (C);IAAyne P62241;Q5J R95 K7ENA3;W4 VSQ8;K7EI N2;Q9BRJ7; Q9BRJ7-2 40S ribosomal protein S8 Protein syndesmos RPS8 9.08E NUDT16L1 2.49E SGSWAAIY QDIRHEAS DFR QLLEMA CNEK MEKDREIC R LGPAPPGA ASICRPTR Carbamidomet hyl (C);Oxidation (M); P18031 Q5TBR0;Q9 NR45 Q8WVV4;Q 8WVV4-1 P35568 Tyrosine-protein phosphatase non-receptor type 1 Sialic acid synthase PTPN1 1.50E NANS 4.90E Protein POF1B POF1B 7.73E Insulin receptor substrate 1 IRS1 7.34E S266

267 AAAPAPVS EAVCR E9PDE4;E7 ES10;E7EV Y3;B7Z574; P ;P ;P20810;P ;P ;P ;P ;E7EQ12;A 0A0A0MR45 ;E7EQA0;H0 Y7F0;H0YD 33;H0Y9H6; E9H5;P ;P ;P Calpastatin CAST 1.48E TIAECLADE LINAAK YTQSNSVC YAK TQLAVCQQ R DIKWDFTP CKNLR M0R0F0;M0 R0R2;P4678 2;M0QZN2 H7C084;P ;P31939;H 7C1S2 Q02790;H0 YFG2 P ;P38606;C 9JA17;C9JV W8 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed Bifunctional purine biosynthesis protein PURH;Phosphor ibosylaminoimid azolecarboxami de formyltransferas e;imp cyclohydrolase Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidylprolyl cis-trans isomerase FKBP4, N- terminally processed V-type proton ATPase catalytic subunit A RPS5 1.03E ATIC 3.55E FKBP4 7.48E ATP6V1A 3.59E LRECLPLIIF LR AVCMLSNT TAVAEAWA R STLTDSLVC KAGIIASAR SCLLLR A6NH36;P F5H5D3;Q9 BQE3 P13639 E7END7;P ;P62820;A 0A087WTI1; E9PLD0;P ;Q9H0U4; Q S ribosomal protein S4, X isoform Tubulin alpha- 1C chain Elongation factor 2 Ras-related protein Rab- 1A;Ras-related protein Rab- 1B;Putative Rasrelated protein Rab-1C RPS4X 7.21E TUBA1C 1.76E EEF2 3.04E RAB1A;RAB1 B;RAB1C 2.88E GLYDGPVC EVSVTPK Q ;Q16555 Dihydropyrimidin ase-related protein 2 DPYSL2 1.19E S267

268 QVCQLPGL FSYAQHIAS IDGR AAAAAAEA GDIPIYICHQ ELR Q9Y6C9;E9 PIE4 A0A0A0MS Q7;A0A0A0 MRG0 Mitochondrial carrier homolog 2 Calcitonin receptor MTCH2 1.36E CALCR 2.77E AGAHVNSE DDRTSCIVR LTEGCSFR R Q9ULJ7;Q9 ULJ7-2 C9J1C5;H0 YMV8;Q71U M5;P42677 Ankyrin repeat domaincontaining protein 50 40S ribosomal protein S27;40S ribosomal protein S27-like ANKRD E RPS27L;RPS E LQEALDAE MLEDEAGG GGAGPGGA CK AVYTQDCP LAAAK Oxidation (M); H3BQZ7;Q1 KMD3 H3BPK7;P4 9588;P Heterogeneous nuclear ribonucleoprotei n U-like protein 2 Alanine--tRNA ligase, cytoplasmic HNRNPUL2- BSCL2;HNRN PUL2 4.04E AARS 3.91E LISPNLGVV FFNACEAA SR VCLCQGSA GSGAIGPV EAAIR LEDVENLG CR AALAACPS SPFPPAMP R EAPSPTCP DLGAK ALAQEWGC PFMETSAK GGCPGGEA TLSQPPPR NAFATPTIS LQESCDYL DR LTGMAFRV PTANVSVV DLTCR Carbamidomet hyl (C);IAAyne Q66K74-2;Q66K74 Q9Y3E2 Q9UJX3-2;Q9UJX3 Q8N2G8-3;Q8N2G8 O00257 A0A087X2C 3;Q9Y3L5 P20290 Q7KZ85-3;Q7KZ85 E7EUT5;P ;P04406 Microtubuleassociated protein 1S;MAP1S heavy chain;map1s light chain BolA-like protein 1 Anaphasepromoting complex subunit 7 GH3 domaincontaining protein E3 SUMOprotein ligase CBX4 Ras-related protein Rap-2c Transcription factor BTF3 Transcription elongation factor SPT6 Glyceraldehyde- 3-phosphate dehydrogenase MAP1S 4.75E BOLA1 6.74E ANA7 9.82E GHDC 3.00E CBX4 2.16E RAP2C 4.16E BTF3 5.35E SUPT6H 6.36E GAPDH 1.92E ISLGLPVGA VINCADNTG AK P62829;C9J D32;B9ZVP 7;J3KT29 60S ribosomal protein L23 RPL E ACIAEK LQGSCTSC PSSIITLK Carbamidomet hyl (C);IAAyne P ;P60981 C9J8Q1;F8 W9P7;H7C5 37;Q9UMS0-2;Q9UMS0-3;Q9UMS0 Destrin DSTN 9.83E NFU1 iron-sulfur cluster scaffold homolog, NFU1 1.07E GCITIIGGG DTATCCAK VVVVSHDE NLCR 2 Carbamidomet hyl (C);IAAyne P ;P00558 Q7L5L3-1;Q7L5L3 Phosphoglycerat e kinase 1 Glycerophospho diester phosphodiestera PGK1 1.69E GDPD3 5.67E S268

269 VDVFREDL CTK NVLVIGTTG SQTTFLPE GELPECAR VILITPTPLC ETAWEEQC IIQGCK 2 Carbamidomet hyl (C);IAAyne se domaincontaining protein 3 Proteasome activator complex subunit 1 Protein DDI1 homolog 2 Q ;Q06323;Q Q5TDH0;Q5 TDH0-3 C9JDY4;C9 J5J2;C9JE0 2;H7C5G1; Q2TAA2-2;Q2TAA2 Isoamyl acetatehydrolyzing esterase 1 homolog PSME1 1.14E DDI2 1.98E IAH1 5.86E LRECELSP GVNR H7C3A1;Q9 BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 Serrate RNA effector molecule homolog SRRT 2.81E KAIEIDEQQ GCKEQER EGGQYGLV AACAAGGQ GHAMIVEA YPK YAICSALAA SALPALVM SK Oxidation (M); Q9NVK5-2;Q9NVK5 B5MD38;F5 GZQ3;P ;P55084 P36578;H3B M89;H3BTP 7 FGFR1 oncogene partner 2 Trifunctional enzyme subunit beta, ;3- ketoacyl-coa thiolase 60S ribosomal protein L4 FGFR1OP2 1.87E HADHB 1.21E RPL4 1.89E NQLKETTE AACR E9PFN5;Q9 Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3; Q9Y2Q3-2 Glutathione S- transferase kappa 1 GSTK1 3.07E FVQCPDGE LQK Q9Y230-2;Q9Y230;M 0R0Y3 RuvB-like 2 RUVBL2 3.72E VLVTTNVCA R I3L352;I3L0 H8;F6QDS0; H3BQK0;Q9 UMR2-3;Q9NUU7-2;Q9UMR2-2;Q9UMR2-4;Q9NUU7; Q9UMR2 ATP-dependent RNA helicase DDX19B;ATPdependent RNA helicase DDX19A DDX19A;DDX 19B 3.05E LGEMIETAY GENFACSK TKDDIIICEI GDVFK FRDQDLAS CDRDR Q8IYQ7 Q9Y512 Q96HJ9-2;Q9Y383-3;Q9Y383-2;Q9Y383 Threonine synthase-like 1 Sorting and assembly machinery component 50 homolog Putative RNAbinding protein Luc7-like 2 THNSL1 2.44E SAMM E LUC7L2 2.45E DDDRTPGL HGDCDDDK YR KDVLIEFYA PWCGHCK Carbamidomet hyl (C);IAAyne O95159 P13667 Zinc finger protein-like 1 Protein disulfideisomerase A4 ZFPL1 3.48E PDIA4 2.80E S269

270 DIEDTLSGI QTAGCGST FFR TVFAEHISD ECKRR A0A0A0MT D5;Q8IYU8 B5MCW2;H 7C422;G5E 9G0;P39023 ;F8WCR1;H 7C3M2 Calcium uptake protein 2, 60S ribosomal protein L3 MICU2 9.71E RPL3 1.45E VFFIQACQG DNYQK H7C0E2;Q ;Q ;Q14790;Q ;Q Caspase- 8;Caspase-8 subunit p18;caspase-8 subunit p10 CASP8 1.43E TACNVEEA FINTAK Q5HYI5;Q8 WUD1-2;Q8WUD1 Ras-related protein Rab-2B DKFZp313C1 541;RAB2B 1.96E GVSASAVP FTPSSPLLS CSQEGSR J3QL89;J3Q RU8;Q9Y2X 7;Q9Y2X7-3 ARF GTPaseactivating protein GIT1 GIT1 6.76E LVIYGGMS GCR AITIAGIPQS IIECVK Oxidation (M); A6NEM2;P ;P51610;P ;P F8VXH9;H3 BRU6;F8VZ X2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;F8VRH0 Host cell factor 1;HCF N- terminal chain 1;HCF N- terminal chain 2;HCF N- terminal chain 3;HCF N- terminal chain 4;HCF N- terminal chain 5;HCF N- terminal chain 6;HCF C- terminal chain 1;HCF C- terminal chain 2;HCF C- terminal chain 3;HCF C- terminal chain 4;HCF C- terminal chain 5;HCF C- terminal chain 6 Poly(rC)-binding protein 2 HCFC1 2.70E BP2 5.96E CPLASTNK R NAFACFDE EATGTIQED YLR A0A087WT Y1;Q9Y2S0-2 J3QRS3;P1 9105;O DNA-directed RNA polymerases I and III subunit RPAC2 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B POLR1D 7.26E MYL12A;MYL 12B 9.84E S270

271 ATVAPEDV SEVIFGHVL AAGCGQNP VR FNAHGDAN TIVCNSK AKPYEGSIL EADCDILIP AASEK KICSHSAPE QQAR ADLVISHAG AGSCLETLE K VACIGAWH PAR Q9BWD1;Q 9BWD1-2 Acetyl-CoA acetyltransferas e, cytosolic ACAT2 6.26E P09382 Galectin-1 LGALS1 6.12E P ;P ;P00367 O75683 A0A096LNJ 4;A0A087W X43;D6RE8 4;A0A087W TT9;Q9NP7 3-2;Q9NP73 B5MCW2;H 7C422;G5E 9G0;P39023 ;Q92901 Glutamate dehydrogenase 1, Surfeit locus protein 6 Putative bifunctional UDP-Nacetylglucosami ne transferase and deubiquitinase ALG13 60S ribosomal protein L3;60S ribosomal protein L3-like GLUD1 8.76E SURF6 7.46E ALG E RPL3;RPL3L 1.14E QCEGITSPE GSK AEAAALST QCR GGCIIR LLDLVQQS CNYK ACPRPEGL NFQDLK Q9Y570-2;Q9Y570;Q 9Y570-4 Q9H6T0-2;Q9H6T0 P ;P52209;K 7ELN9 B1AHD1;P Q5TEJ0;P15 927;P ;P Protein phosphatase methylesterase 1 Epithelial splicing regulatory protein 2 6- phosphoglucona te dehydrogenase, decarboxylating NHP2-like protein 1;NHP2- like protein 1, N- terminally processed Replication protein A 32 kda subunit PPME1 3.54E ESRP2 1.28E PGD 4.92E NHP2L1 6.57E RPA2 9.23E VACITEQVL TLVNKR NVDRYCEA AR B7Z4L4;P B8ZZR0;F8 WBF5;A0A0 87WVK0;P4 9759;P Dolichyldiphosphooligos accharide-- protein glycosyltransfera se subunit 1 Dual specificity protein kinase CLK1 RPN1 3.69E CLK1 2.32E TKWGTIEVE NTTHCEFA YLR Q9UHD8-4;Q9UHD8-9;Q9UHD8-3;Q9UHD8-8;Q9UHD8-7;Q9UHD8-2;Q9UHD8-5;Q9UHD8 Septin-9 SEPT9 1.51E LLQDYPITD VCQILQK Q9NVG8-2;Q9NVG8; Q9NVG8-3 TBC1 domain family member 13 TBC1D E GPTKEELC K Q96TA1-2;Q96TA1 Niban-like protein 1 FAM129B 7.57E S271

272 AQDSDTLC VGGFIR ELEQVCNPI ISGLYQGA GGPGPGGF GAQGPK APGAAAPS SGPGAA AR ALYDNVPE CAEELAFR Q9ULJ7 V9GZ37;P ;P08107 Q8TCU6-3;Q8TCU6 D6RGD7;D6 RBQ2;Q ;Q ;Q14511 Ankyrin repeat domaincontaining protein 50 Heat shock 70 kda protein 1A/1B Phosphatidylino sitol 3,4,5- trisphosphatedependent Rac exchanger 1 protein Enhancer of filamentation 1;Enhancer of filamentation 1 p55 ANKRD E HSPA1A 3.59E PREX1 1.77E NEDD9 1.35E GCNPSGHT QSVTTPEP AKEGTK O75363;H7 C1E7;A0A0 A0MRP7;H0 Y542;G3XA F7;O Breast carcinomaamplified sequence 1 BCAS1 3.46E CQLTPNDR FILLACDGL FK QGFGNLPIC MAK WGTIEVEN TTHCEFAYL R Carbamidomet hyl (C);IAAyne H7C2I8;F8S NU7;Q9H0C 8 F5H2F4;P11 586;V9GYY 3 Q9UHD8-4;Q9UHD8-9;Q9UHD8-3;Q9UHD8-8;Q9UHD8-7;Q9UHD8-2;Q9UHD8-5;Q9UHD8 Integrin-linked kinaseassociated serine/threonine phosphatase 2C ILKAP;ILKAP3 5.83E C-1- MTHFD1 2.41E tetrahydrofolate synthase, cytoplasmic;met hylenetetrahydro folate dehydrogenase; Methenyltetrahy drofolate cyclohydrolase;f ormyltetrahydrof olate synthetase;c-1- tetrahydrofolate synthase, cytoplasmic, N- terminally processed Septin-9 SEPT9 3.83E YYGGAEVV DEIELLCQR P ;P ;P34897;G 3V241;G3V3 Y8;G3V4T0; G3V4X0;G3 V2W0;G3V2 E4;G3V540; G3V5L0;G3 V4W5 Serine hydroxymethyltr ansferase, SHMT2 7.90E AVSVNEGY KVCER Q9C0I1-3;Q9C0I1-2;Q9C0I1 Myotubularinrelated protein 12 MTMR E S272

273 ATCAPQHG APGPGPAD ASK A0A087WW Y3;Q5HY54; Q60FE5;P ;P21333 Filamin-A FLNA 2.45E GSDELFST CVTNGPFIM SSNSASAA NGNDSKK Oxidation (M); P26599;P ;P ;K7EKX4;K 7EKJ7 Polypyrimidine tract-binding protein 1 PTBP1 3.32E CYEMASHL R K7EJ44;P07 737;CON P02584 Profilin-1 PFN1 1.82E SLWSSLCL GPAPAPPG PVSPEGR H3BTH4;H3 BN66;H3BR S6;Q9BRR6-6;Q9BRR6-2;Q9BRR6 ADP-dependent glucokinase ADPGK 1.50E NFILDQCNV YNSGQR VTQNLPMK EGCTEVSLL R NAGNCLSP AVIVGLLK RTIQVPE PILR Oxidation (M); H3BQZ7;Q1 KMD3 H3BQZ7;Q1 KMD3 Q5SZU1;O H7BXY3;Q7 L2E3-3;Q7L2E3;Q 7L2E3-2 Heterogeneous nuclear ribonucleoprotei n U-like protein 2 Heterogeneous nuclear ribonucleoprotei n U-like protein 2 D-3- phosphoglycerat e dehydrogenase Putative ATPdependent RNA helicase DHX30 HNRNPUL2- BSCL2;HNRN PUL2 HNRNPUL2- BSCL2;HNRN PUL2 6.28E E PHGDH 1.07E DHX E VCTLAIIDP GDSDIIR ATSAGSSP SCSLAGR KLGNNCVF APADVTSE KDVQTALAL AK ESLCDSPH QNLSRPLLE NK E5RI99;P Q9BXB5-2;Q9BXB5 Q ;Q99714;Q 5H928 U3KPT1;C9 JDJ7;C9J5L 1;E7EW00; H0Y8D9;E7 ET15;O ;O S ribosomal protein L30 Oxysterolbinding proteinrelated protein 10 3-hydroxyacyl- CoA dehydrogenase type-2 U2 snrnpassociated SURP motifcontaining protein RPL E OSBPL E HSD17B E U2SURP 2.58E FGVQTDRQ DKCALGWD HQEK Q ;Q14247;Q Src substrate cortactin CTTN 3.22E VGLGICYD MR IIYGGSVTG ATCK H7C579;Q9 NQR4 P ;P60174;P Omega-amidase NIT2 Triosephosphate isomerase NIT2 5.40E TPI1 6.31E AIGAVPLIQ GEYMIE K TILTLTGVS TLGDVKNN QESDCVSK Oxidation (M); H7C1V0;H7 C469;P A6NDG6;H3 BV17 Cathepsin D;Cathepsin D light chain;cathepsin D heavy chain Phosphoglycolat e phosphatase CTSD 2.46E PGP 0.00E S273

274 AAAGEFAD DSSVKR G3XAM7;P3 5221;P ;E5RHV7;E 5RGY6;E5R G03;E5RJ41 ;E5RIB1 Catenin alpha-1 CTNNA1 8.62E LTCEGAVA VAEFIAESP R LTGIKHELQ ANCYEEVK DR AVAILCNHQ R VLIANRGEI ACR IYFGSNIPN MFVDSSCA LK ENKPSIIFID EIDSLCGSR TLIQNCGAS TIR ICSHSAPEQ QAR EIVHLQAGQ CGNQIGAK O75864 G3V1A4;E9 PP50;E9PK 25;P23528 Protein phosphatase 1 regulatory subunit 37 PPP1R E Cofilin-1 CFL1 3.53E P11387 DNA topoisomerase 1 TOP1 1.09E Q96RQ3;F8 Methylcrotonoyl- MCCC1 2.84E WDI3;G5E9 CoA X5 carboxylase subunit alpha, O75477 Erlin-1 ERLIN1 1.30E O75351 B4DUR8;P ;P49368 O75683 P04350;P68 371;M0R2D 3;M0R0X0; M0R2T4;M0 QY85;M0QY 37;M0QX14; M0R042;M0 QZL7;M0R2 78;M0QYM7 Vacuolar protein sortingassociated protein 4B T-complex protein 1 subunit gamma Surfeit locus protein 6 Tubulin beta-4a chain;tubulin beta-4b chain VPS4B 1.14E CCT3 2.45E SURF6 7.16E TUBB4A;TUB B4B 4.09E QKICYAK AACCLAGA R VKDSDDVP MVLVGNKC DLPTR VLDALFV QGGTTAIP GAFGCGK RGSDELFS TCVTNGPFI MSSNSASA ANGNDSKK Carbamidomet hyl (C);IAAyne Oxidation (M); Carbamidomet hyl (C);IAAyne P ;P78527 M0R0U3;M0 R261;O DNA-dependent protein kinase catalytic subunit 6- phosphoglucono lactonase PRKDC 1.95E PGLS 1.73E P01111 GTPase NRas NRAS 1.51E P ;P38606 P26599;P ;P ;K7EKX4;K 7EKJ7 V-type proton ATPase catalytic subunit A Polypyrimidine tract-binding protein 1 ATP6V1A 7.83E PTBP1 9.89E WASGLTPA QNCPR Q6P1N7;C9 JA35;A2AB9 0;A0A0A0M SV9;O ;O15533;O Tapasin TAPBP 1.28E S274

275 SLYTYCPET EEINKLTGI GPK AVCEADQS HGGPR VQENSAYIC SRR AEAGEAGQ ATAEAECH R SGANVLICG PNGCGK QVVDCQLA DVNNIGK GDLCALAE RLDIVAGCR ALRPGDPG FCAR Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne Q08AD1-2;Q08AD1-3;Q08AD1 F8VNX8;O Q9Y3T9 O ;O95671;O P ;P28288 P ;P28838 K7EN58;Q6 QNY0 Q96ST2-2;Q96ST2-3;Q96ST2 Calmodulinregulated spectrinassociated protein 2 TRAF-type zinc finger domaincontaining protein 1 Nucleolar complex protein 2 homolog N- acetylserotonin O- methyltransferas e-like protein ATP-binding cassette subfamily D member 3 Cytosol aminopeptidase Biogenesis of lysosomerelated organelles complex 1 subunit 3 Protein IWS1 homolog CAMSAP2 2.34E TRAFD1 1.19E NOC2L 4.61E ASMTL 1.70E ABCD3 5.92E LAP3 4.20E BLOC1S3 1.75E IWS1 7.94E INISEGNCP ER F8VXH9;H3 BRU6;F8VZ X2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;F8W0G4;F 8W1G6;J3Q T27;E9PFP8 ;P ;P ;P ;P ;P57721;F8 VTZ0;Q Poly(rC)-binding protein 2;Poly(rC)- binding protein 3;Poly(rC)- binding protein 1 BP2;BP 3;BP1 1.22E EMFPYEAS TPTGISASC R WAWEAVEA LENHCR AILFSQPLQI TDTQQGCI APVELR IIPTLEEGLQ LPSPTATSQ LPLESDAVE CLNYQHYK H0YJH7;G5 E972;P ;P42167 P33908 Q8NBF2-2;Q8NBF2 Q5T6W1;P6 1978;P Laminaassociated polypeptide 2, isoforms beta/gamma;thy mopoietin;thym opentin Mannosyloligosaccharide 1,2-alphamannosidase IA NHL repeatcontaining protein 2 Heterogeneous nuclear ribonucleoprotei n K TMPO 3.21E MAN1A1 4.25E NHLRC2 1.45E HNRNPK 4.86E S275

276 IKADPDGPE AQAEACSG ER SWMEGLTL QDYSEHCK QAVLGAGL PISTTTIN KVCASGMK DVCTELLPL IKPQGR MREIVHLQA GQCGNQIG AK Carbamidomet hyl (C);IAAyne Oxidation (M); J3QSY4;D6 RC52;D6RC B9;Q9NX24 O00487 P24752;E9P KF3;H0YEL 7;P P16152 P04350;P68 371;M0R2D 3;M0R0X0; M0R2T4;M0 QY85;M0QY 37;M0QX14; M0R042;M0 QYM7 H/ACA ribonucleoprotei n complex subunit 2 26S proteasome non-atpase regulatory subunit 14 Acetyl-CoA acetyltransferas e, Carbonyl reductase [NADPH] 1 Tubulin beta-4a chain;tubulin beta-4b chain NHP2 3.68E PSMD E ACAT1 7.45E CBR1 5.27E TUBB4A;TUB B4B 3.77E TEEILVK A0A087WW Y3;Q5HY54; Q60FE5;P ;P21333 Filamin-A FLNA 5.46E NCDKGQSF FIDAPDSPA TLAYR DIRPECRED FVLSITGK P ;P53384 P ;P ;P ;P ;P ;P08651 Cytosolic Fe-S cluster assembly factor NUBP1 Nuclear factor 1 C-type NUBP1 1.24E NFIC 1.15E GCTATLGN FAK H0YEN5;P1 5880;E9PQ D7 40S ribosomal protein S2 RPS2 1.81E GSSCFECT HYQSFLEY R SESELIDEL SEDFDRSE CK Carbamidomet hyl (C);IAAyne P ;P21964 E9PDE4;E7 ES10;E7EV Y3;B7Z574; P ;P ;P20810;P ;P ;P ;P ;E7EQ12;A 0A0A0MR45 ;E7EQA0;H0 Y7F0;H0YD 33;H0Y9H6; E9H5;P ;P ;P ;D6RC54 Catechol O- methyltransferas e COMT 9.06E Calpastatin CAST 1.12E S276

277 IGRPSETGII GIIDPECR F5GWI0;F5 GZY8;F5H2 L3;F5GY55; Q16531 DNA damagebinding protein 1 DDB1 1.42E ANCIDSTAS AEAVFASE VKK M0QXL5;M0 R2Q4;P220 87;M0R299 rrna 2'-Omethyltransferas e fibrillarin FBL 6.39E ALANSLAC QGK P04075;P ;J3KPS3;H 3BR68 Fructosebisphosphate aldolase A ALDOA 1.81E SSGCFPNM AAK LLPAITILGC R SGDAAIVD MVPGKPMC VESFSDYP PLGR Oxidation (M); Q96I24 Q96IJ6;Q96I J6-2 A0A087WV Q9;P ;Q5VTE0;P Far upstream element-binding protein 3 Mannose-1- phosphate guanyltransferas e alpha Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 FUBP3 2.72E GMPPA 3.06E EEF1A1;EEF1 A1P5 5.49E YRNPVSQC MR Oxidation (M); K7EJ99;A0A 0A0MSV7;K 7EJM5;A0A 087WX29;K 7EN94;B1A KP7;G3V16 2;A0A087X2 60;A0A087 WYY0;Q TAR DNAbinding protein 43 TARDBP 1.01E LNIISNLDCV NEVIGIR LNCQVIGAS VDSHFCHL AWVNTPK VCENIPIVL CGNKVDIK Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne B3KQV6;P3 0153;H0YD G7;P ;P ;P30154;P ;P A0A0A0MSI 0;Q06830 B4DV51;F5 H018;B5MD F5;J3KQE5; P62826 Serine/threonine -protein phosphatase 2A 65 kda regulatory subunit A alpha isoform;serine/t hreonine-protein phosphatase 2A 65 kda regulatory subunit A beta isoform PPP2R1A;PP P2R1B 3.23E Peroxiredoxin-1 PRDX1 1.78E GTP-binding nuclear protein Ran RAN 4.06E IGKPHTV K H0YEN5;P1 5880;I3L404 ;E9PPT0;E9 PM36;E9PM M9 40S ribosomal protein S2 RPS2 1.57E NLSFFLTPP CAR J3KPM9;P ;P42224 Signal transducer and activator of transcription;sig nal transducer and activator of transcription 1- alpha/beta STAT1 9.53E S277

278 GLGTDEDS LIEIICSR P07355;A6N MY6;P ;H0YLE2;H 0YN52;H0Y NA0;H0YN2 8;H0YL33;H 0YMM1;H0Y NP5;H0YKS 4;H0YMD0; H0YMU9;H0 YM50;H0YN 42 Annexin A2;Putative annexin A2-like protein;annexin ANXA2;ANXA 2P2 0.00E AFQYVETH GEVCPANW TPDSPTIKP SPAASK CLSSLKDE R EALSPST VSTK LECVEPNC R EADQKEQF SQGSPSNC LETSLAEIF PLGK IANLGSCND SKLEFR NGGGGGG GGSGLHCA GNGGGGG GGPR GADCCVLV FDVTAPNTF K QVLIRSK Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne P ;P30048 P ;P52209;K 7ELN9 Q08AD1-2;Q08AD1-3;Q08AD1 H0Y5B4;H7 BZ11;J3KQ N4;Q969Q0; P83881 Q9NQ88 Thioredoxindependent peroxide reductase, 6- phosphoglucona te dehydrogenase, decarboxylating Calmodulinregulated spectrinassociated protein 2 60S ribosomal protein L36alike;60S ribosomal protein L36a Fructose-2,6- bisphosphatase TIGAR PRDX3 4.49E PGD 1.14E CAMSAP2 4.20E RPL36A;RPL3 6A- HNRNPH2;RP L36AL 8.38E TIGAR 1.48E Q9HCY8 Protein S100- A14 S100A E Q96L92- Sorting nexin-27 SNX E ;Q96L92;H 7C603 C9J592;P I3L3P7;P62 244;H3BV27 ;H3BT37;I3L 303;I3L246; H3BN98 Ras-related protein Rab-7a 40S ribosomal protein S15a RAB7A 4.64E RPS15A 9.35E LVVPATQC GSLIGKGG CK NMACVQR Carbamidomet hyl (C);IAAyne Oxidation (M); Q15365 X6RJP6;P37 802;P Poly(rC)-binding protein 1 BP1 8.36E Transgelin-2 TAGLN2 2.54E LICCDILDVL DKHLIPAAN TGESK ELSFSGI EGGLR AIALFTPDA CGLSDPAH VESLQEK Carbamidomet hyl (C);IAAyne P ;P62258 Q9NVG8-2;Q9NVG8 P protein epsilon TBC1 domain family member 13 Nuclear receptor subfamily 2 group F member 6 YWHAE 3.89E TBC1D E NR2F6 5.47E S278

279 SLDTASVDL CIKPK Q9NVH6-4;Q9NVH6-7;Q9NVH6-2;Q9NVH6-5;Q9NVH6-3;Q9NVH6; Q9NVH6-8 Trimethyllysine dioxygenase, TMLHE 5.02E GLCGAIHSS IAK ALVDGT QVR IGSSLYALG TQDSTDICK FFLK IAVYSCPFD GMITETK P ;P36542 E7EPB3;P A0A0A0MRI 2;Q9UNH7-2;Q9UNH7 P ;P50990;P ATP synthase subunit gamma, 60S ribosomal protein L14 Sorting nexin- 6;Sorting nexin- 6, N-terminally processed T-complex protein 1 subunit theta ATP5C1 4.39E RPL E SNX6 2.67E CCT8 4.40E LTTPTYGDL NHLVSATM SGVTTCLR VIGIECSSIS DYAVK P04350;P68 371;M0R2D 3;Q5ST81;Q 5JP53;P074 37;Q9BVA1; Q13885 E9PKG1;H7 C2I1;Q ;Q ;Q ;Q99873;E 9PIX6;A0A0 87X1W2;E9 PMW9;E9PI 83;E9PNR9; E9PQ98;H0 YDE4 Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta chain;tubulin beta-2b chain;tubulin beta-2a chain Protein arginine N- methyltransferas e 1 TUBB4A;TUB B4B;TUBB;TU BB2B;TUBB2 A 1.71E PRMT1 1.23E VLFGEDDS LLRVDCIR KTGEGS KTWDR H0Y8E8;F8 W6N3;Q G3XAN0;P6 0866;P Ubiquitin carboxylterminal hydrolase BAP1 40S ribosomal protein S20 BAP1 2.61E RPS E IGLYPANYV ECVGA ILTCPK Q9UKS6 P ;P ;P15924 Protein kinase C and casein kinase substrate in neurons protein 3 PACSIN3 5.08E Desmoplakin DSP 1.32E VDENFDCV EADDVEGKI R TFLFCTPFT PDGR REDFCPR YSYVCPDL VKEFNKYD TDGSK O ;O14929 Q96HP0;K7 ESB7 Q9H0W8-2;Q9H0W8 P61158;B4D XW1 Histone acetyltransferas e type B catalytic subunit HAT1 1.65E Dedicator of DOCK6 2.30E cytokinesis protein 6 Protein SMG9 SMG9 5.92E Actin-related protein 3 ACTR3 1.18E S279

280 ALVPLGIGIA TGEQCHNR J3QL81;Q7L 5Y1-7;Q7L5Y1-6;Q7L5Y1-2;Q7L5Y1 Mitochondrial enolase superfamily member 1 ENOSF1 7.03E EAESCDCL QGFQLTHS LGGGTGSG MGTLLLSK LCYVALDFE QEMATAAS SSSLEK SAVETQAN NLICR CSATPSAQ VKPIVSASP PSR NRKHPSSP ECLVSAQK Carbamidomet hyl (C);IAAyne Oxidation (M); A0A075B73 6;Q5SQY0; Q3ZCM7 P60709;P63 261;Q6S8J3 ;I3L4N8 O75362 H0Y3K4;Q9 6EV2 A0A087WY6 1;Q ;Q14980;Q ;Q ;Q ;F5H6Y5;F 5H4J1;F5H0 Z7;F5H763; F8W6T3;F5 H1L0;F5GZ W1;F5H2F3; F5H3L6 Tubulin beta-8 chain Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;pot E ankyrin domain family member E Zinc finger protein 217 RNA-binding protein 33 Nuclear mitotic apparatus protein 1 TUBB8 1.07E ACTB;ACTG1; POTEE 5.22E ZNF E RBM E NUMA1 1.69E CTLAEK G3V1A4;E9 PP50;E9PK 25;P23528 Cofilin-1 CFL1 1.17E CSDAAGYP HATHDLEG PPLDAYSIQ GQHTISPLD LAK QRPLTASL QCNSTAQT EK TKSCSGVE FSTSGSSN TDTGK Q15365 C9JUJ0;Q9 UFW8 A0A0A0MR 02;P ;P45880;P ;A2A3S1;Q 5JSD2;Q5J SD1 Poly(rC)-binding protein 1 CGG triplet repeat-binding protein 1 Voltagedependent anion-selective channel protein 2 BP1 2.84E CGGBP1 2.24E VDAC2 9.56E FLTFKDCDP GEVNK C9JG87;Q9 NYK5;Q9NY K5-2 39S ribosomal protein L39, MRPL E VLPSCDLA R LEGIPAYIVV PQTAPDCK Q96LJ7 I3L4B4;Q9G ZT4 Dehydrogenase/ reductase SDR family member 1 Serine racemase DHRS1 1.50E SRR 5.04E S280

281 LCTQLEGL QSTVTGHV ER LREIQLA ESR Q6P2E9-2;Q6P2E9 H3BP71;O ;O75150;A 0A087WTK2 Enhancer of mrnadecapping protein 4 E3 ubiquitinprotein ligase BRE1B EDC4 5.20E RNF E CPFYAAEQ DKGALEGS SCPFR LLMEQESS ACSR GFAGVCGF GGPYGETV ATGPYR ARGTGELT QLLNSLCTA VK TVDLGLTG NHGVVHPS LADSANKF EENTYCFG R NCPHVVVG TPGR Carbamidomet hyl (C);IAAyne Oxidation (M); A0A087WT4 4;P ;P30519 O ;O96011 Q9NZB2;Q9 NZB2-6 P09467 Q9H845;H0 Y8Z9 K7EQN7;B1 Q2N1;O ;O00148;K 7EPJ3 Heme oxygenase 2 Peroxisomal membrane protein 11B Constitutive coactivator of PPAR-gammalike protein 1 Fructose-1,6- bisphosphatase 1 Acyl-CoA dehydrogenase family member 9, ATP-dependent RNA helicase DDX39A HMOX2 9.89E PEX11B 8.86E FAM120A 7.92E FBP1 1.34E ACAD9 9.69E DDX39A;DDX E SGQGAFGN MCR P36578;H3B TP7;H3BU3 1 60S ribosomal protein L4 RPL4 2.81E EAAAALLPT PESLVS R FACHSASLT VR TGQATVAS GIPAGWMG LDCGPESS KK AVDERFPG CMQGR O ;O43149 C9IZL7;C9J YS8;Q ;Q15233 P ;P00558 A0A0A0MS7 4;H0YML5;B 4DW73;H0Y M31;Q ;Q16822;H 0YMU6;H0Y NG4 Zinc finger ZZtype and EFhand domaincontaining protein 1 Non-POU domaincontaining octamer-binding protein Phosphoglycerat e kinase 1 Phosphoenolpyr uvate carboxykinase [GTP], ZZEF1 3.08E NONO 4.58E PGK1 1.95E K2 3.84E LCVQNSPQ EAR A0A0A0MT5 6;E9PID8;E 7EWR4;P ;P33240 Cleavage stimulation factor subunit 2 CSTF2 1.31E SELECVTNI TLANVIR VVQHLCQR Q9Y6W5-2;Q9Y6W5 H0YAR9;Q8 WUY1 Wiskott-Aldrich syndrome protein family member 2 WASF2 5.43E Protein THEM6 THEM6 3.50E S281

282 GAYRDCLG RLDLQYAK Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E 9PMV1 Plectin PLEC 1.30E NVDAILEEY ANCK Q5JXX2;A0 A088AWL8; A0A0A0MT5 9;Q15014 Mortality factor 4-like protein 2 MORF4L2 6.18E IAVAAQNCY K EMFPYEAS TPTGISASC R VTQNLPMK EGCTEVSLL R LFDDLKCD AERENFHR GSDELFST CVTNGPFIM SSNSASAA NGNDSKK Oxidation (M); P ;P60174 H0YJH7;G5 E972;P ;P42167 H3BQZ7;Q1 KMD3 Q9H3U1-2;Q9H3U1 P26599;P ;P ;K7EKX4;K 7EKJ7 Triosephosphate isomerase Laminaassociated polypeptide 2, isoforms beta/gamma;thy mopoietin;thym opentin Heterogeneous nuclear ribonucleoprotei n U-like protein 2 Protein unc-45 homolog A Polypyrimidine tract-binding protein 1 TPI1 4.06E TMPO 3.21E HNRNPUL2- BSCL2;HNRN PUL2 3.90E UNC45A 6.15E PTBP1 3.32E LGYILTCPS NLGTGLR VVTQNICQY R P12532;P17 540;P A0A087X2B 6;G3V119;H 0YB24;Q8N 163-2;Q8N163 Creatine kinase U-type, ;Cr eatine kinase S- type, Cell cycle and apoptosis regulator protein 2 CKMT1A;CKM T2 0.00E CCAR2 6.21E DADADAGG GADGGDG RGGHSCR VCVETVES GAMTK CELSSSVQ TDINLPYLT MDSSGPK VVVVASAA HCR AADCISEPV NREPPSR Oxidation (M); Q14657 P ;P48735 H0YBG6;P B4DJC5;Q6 UX07-2;Q6UX07 P43304;F5G YK7;E7EM5 6 EKC/KEOPS complex subunit LAGE3 Isocitrate dehydrogenase [NADP], Stress-70 protein, Dehydrogenase/ reductase SDR family member 13 Glycerol-3- phosphate dehydrogenase, LAGE3 4.14E IDH2 2.48E HSPA9 1.35E DHRS E GPD2 5.98E S282

283 CGVPFTDLL DAAK H0Y360;Q ;Q01433;Q ;Q ;Q AMP deaminase 2 AMPD2 2.65E ACGDSTLT QITAGLDPV GR GPAAAAAG YGCPLLSDL TLSPVPR NEEATKHL ECTK P62879;C9J IS1;C9JXA5; C9JZN1 Q5TGY3 E7EU85;E9 PFF5;B4DX Z6;P ;P ;P51114 Guanine nucleotidebinding protein G(I)/G(S)/G(T) subunit beta-2 AT-hook DNAbinding motifcontaining protein 1 Fragile X mental retardation syndromerelated protein 1 GNB2 1.01E AHDC1 9.46E FXR1 2.06E SSSSESED EDVIPATQC LTPGIR J3KQ96;E7 ETY2;Q ;Q ;Q ;Q ;Q13428;Q ;Q Treacle protein TCOF1 1.50E ARREDFCP R VVQSYVEG LCWVLR ASYFQCVQ R CPFTGNVSI R IVDTNEM NTDTFLEEI NK Q9H0W8-2;Q9H0W8 Q9H0D6-2;Q9H0D6 P ;P30281 P62280;M0 QZC5 Q8NDH3-2;Q8NDH3-5;Q8NDH3-4;Q8NDH3; H0YEP3;Q8 NDH3-3 Protein SMG9 SMG9 1.50E '-3' exoribonuclease 2 G1/S-specific cyclin-d3 40S ribosomal protein S11 Probable aminopeptidase NPEPL1 XRN2 7.59E CCND3 4.23E RPS E NPEPL1 0.00E VLNEECDQ NWYKAELN GKDGFIPK J3KT38;J3Q RL5;P ;P62993 Growth factor receptor-bound protein 2 GRB2 1.69E LGGSLIVAF EGCPV AVSTGDCG QVLR LANQAADY FGDAFKQC QYKDTLPK P ;P60981 H7C1L3;A0 A0A0MSU2; Q6PJG2 F8WDK9;Q8 WUM4-3;Q8WUM4; Q8WUM4-2 Destrin DSTN 3.78E ELM2 and SANT domaincontaining protein 1 Programmed cell death 6- interacting protein ELMSAN1 4.98E PDCD6IP 2.75E VACAEEWQ ESR AAGAPGAA CRPGCSQK SCVPSSFA QEESAR Carbamidomet hyl (C);IAAyne O ;O75663 TIP41-like protein TIPRL 3.84E O95685 Protein phosphatase 1 regulatory subunit 3D PPP1R3D 3.63E Q5T0W9 Protein FAM83B FAM83B 3.85E S283

284 STTTSDPP NICK H7C5N8;E7 EPN9;Q9Y5 20-2;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q 9Y520-7 Protein PRRC2C PRRC2C 1.50E ADTLTPEEC QQFKK H0Y3Y4;G3 V1Q4;E7ES 33;E7EPK1; Q ;Q16181 Septin-7 SEPT7 4.85E NKPLGPAG SENEIPTHV LPANLQ AQK CVSVQTDP TDEIPTKK P ;P56159 P ;P ;P ;P ;P ;P ;P ;P ;P18583;P GDNF family receptor alpha-1 GFRA1 3.20E Protein SON SON 9.80E IVDTNEM NTDTFLEEI NKVGK Q8NDH3-2;Q8NDH3-5;Q8NDH3-4;Q8NDH3; H0YEP3;Q8 NDH3-3 Probable aminopeptidase NPEPL1 NPEPL1 1.00E FVAGERDC PR A8MXE8;Q7 Z5J4-4;Q7Z5J4-3;Q7Z5J4-2;Q7Z5J4 Retinoic acidinduced protein 1 RAI1 1.16E SKTSNKPL MIIHHLDEC PHSQALK Oxidation (M); C9J3E2;B5 MC07;O Anterior gradient protein 2 homolog AGR2 1.25E AVGDGILCN TYIDSYKGT VDCVQAR VAAASGHC GAFSGSDS SR SQETECTY FSTPLLLGK LTEGCSFR Carbamidomet hyl (C);IAAyne Q53EL6-2;Q53EL6 Q9NZB2;Q9 NZB2-6 P ;P40926;G 3XAL0 C9J1C5;H0 YMV8;Q71U M5;P42677 Programmed cell death protein 4 Constitutive coactivator of PPAR-gammalike protein 1 Malate dehydrogenase, ;M alate dehydrogenase 40S ribosomal protein S27;40S ribosomal protein S27-like PDCD4 9.71E FAM120A 1.45E MDH2 1.97E RPS27L;RPS E AWQDAAAC PR Q86UR1-3;Q86UR1; Q86UR1-2 NADPH oxidase activator 1 NOXA1 1.07E SCPSFSAS SEGTR D6RCP9;D6 RFG8;P277 07;D6RG38 Deoxycytidine kinase DCK 1.46E S284

285 QYPWGVV QVENENHC DFVK E7EW69;E7 EX04;B5ME 97;Q9P0V9; Q9P0V9-2;D6RDU5; D6RGI3;A0 A087X142;A 6NMH6;D6R ER5;A6NFQ 9;F8W8I8;Q ;Q9NVA2; Q ;Q9P0V9-3;Q9NVA2-2;Q ;Q92599 Septin- 10;Septin- 8;Septin-11 SEPT10;SEPT 11;SEPT8 0.00E QACLTFR EVCPVLDQ FLCHVAK FSYICPDR LCPNSTGA EIR SAPANS TVGVVK Carbamidomet hyl (C);IAAyne Q96SZ5 2- aminoethanethio l dioxygenase C9IZF4;F8W CA1;C9IZ04 ;Q9NY27-2;Q9NY27 C9JQV3;Q8 N1F8-2;Q8N1F8 P ;P35998 H0YFC4;Q8 6YS7;Q86Y S7-2;Q86YS7-3;Q86YS7-4;Q86YS7-5 Serine/threonine -protein phosphatase 4 regulatory subunit 2 Serine/threonine -protein kinase 11-interacting protein 26S protease regulatory subunit 7 C2 domaincontaining protein 5 ADO 1.66E PPP4R2 1.98E STK11IP 1.01E PSMC2 9.17E C2CD5 2.66E GCGTVLLS GPR F8VUA6;G3 V203;H0YH A7;J3QQ67; Q ;Q S ribosomal protein L18 RPL E SGDAAIVD MVPGKPMC VESFSDYP PLGR 2 Oxidation (M); A0A087WV Q9;P ;Q5VTE0;P Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 EEF1A1;EEF1 A1P5 5.49E SASVAPFT CK P ;P49790;P Nuclear pore complex protein Nup153 NUP E NQCTQVVQ ER P ;P ;P15924 Desmoplakin DSP 6.23E SGDAAIVD MVPGKPMC VESFSDYP PLGR A0A087WV Q9;P ;Q5VTE0;P Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 EEF1A1;EEF1 A1P5 5.49E SSVELPPYS GTVLCGTQ AVDKLPDG QEYQR Q14694;Q ;Q ;H3BQC6 Ubiquitin carboxylterminal hydrolase 10 USP E S285

286 EKLCYVALD FEQEMATA ASSSSLEK ADVIVLAGT VCDFR P60709;P63 261;Q6S8J3 ;I3L4N8 M0R026;A1 L0T0;M0QZ X5 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;pot E ankyrin domain family member E Acetolactate synthase-like protein ACTB;ACTG1; POTEE 1.52E ILVBL 8.65E KGVLFGVP GAFTPGCS K P ;P ;P30044 Peroxiredoxin-5, PRDX5 1.31E SQTTYYAQ CYR B7ZC39;B7 ZC38;Q9NR 46;Q9NR46-2 Endophilin-B2 SH3GLB2 5.84E IISNASCTT NCLAPLAK ARGGCPGG EATLSQPP PR KENQWCEE K SGDGSEKA PAPAPPPS GSTSCGDR DSR LILADALCY AHTFNPK RISASCQHP TAFEEAIPK Carbamidomet hyl (C);IAAyne E7EUT5;P ;P04406 P20290 E5RJR5;P Q9H7N4 P ;P28838 C9JBE1;E7 EMB6;E7ET B3;Q9ULA0 Glyceraldehyde- 3-phosphate dehydrogenase Transcription factor BTF3 S-phase kinaseassociated protein 1 Splicing factor, arginine/serinerich 19 Cytosol aminopeptidase Aspartyl aminopeptidase GAPDH 2.27E BTF3 3.75E SKP1 5.50E SCAF1 2.71E LAP3 7.51E DNPEP 2.77E AGGIETIAN EFSDRCTP SVISFGSK Q ;Q ;Q92598;R 4GN69 Heat shock protein 105 kda HSPH1 4.96E FGEVVDCTI KTDPVTGR A0A087WU K2;O ;O ;O14979 Heterogeneous nuclear ribonucleoprotei n D-like HNRNPDL 1.77E VIGVELCPE AVEDAR H7C100;F2Z 2W7;Q8IZ69-2;Q8IZ69 trna (uracil-5-)- methyltransferas e homolog A TRMT2A 4.73E GSDCGIVN VNIPTSGAE IGGAFGGE K F8VS02;P ;P ;P ;P49419 Alphaaminoadipic semialdehyde dehydrogenase ALDH7A1 1.19E AKPTGSGK EEGPAK VVVFIKPTC PYCR Carbamidomet hyl (C);IAAyne D6RCB6;Q8 IUF8-2;Q8IUF8-4;Q8IUF8 Bifunctional lysine-specific demethylase and histidylhydroxylase MINA S286 MINA 2.21E P35754 Glutaredoxin-1 GLRX 3.25E

287 KLPEEEAE CYFHSRPK J3QQV6;Q9 NVS9-2;Q9NVS9-3;Q9NVS9 Pyridoxine-5'- phosphate oxidase PNPO 2.06E NRVIGSGC NLDSAR A0A087WU M2;P ;P ;P ;Q6ZMR3; P00338;P L-lactate dehydrogenase A chain;l-lactate dehydrogenase A-like 6A LDHA;LDHAL 6A 5.88E ATELFVQCL ATYSYR GSAFAIGSD GLCCQSR LNGGLGTS MGCK Carbamidomet hyl (C);IAAyne Q9NRG0 F1T0B3;A0A 087X2G1;Q C9JUW1;C9 JWG0;C9JV G3;C9JQU9; C9JNZ1;A0 A087WYS1; E7EUC7;Q ;Q16851 Chromatin accessibility complex protein 1 ATP-dependent RNA helicase DDX1 UTP--glucose-1- phosphate uridylyltransfera se CHRAC1 1.98E DDX1 4.26E UGP2 7.86E KACQIFVR A0A087X0X 3;P ;P52272;M 0QY96;M0R 2I7 Heterogeneous nuclear ribonucleoprotei n M HNRNPM 2.66E ACPLQPDH TNDEKE DLQPFPTC QALVYR GALEGSSC PFR H0YKX3;Q Q14137;Q A0A087WT4 4;P ;P30519 NAassociated factor Ribosome biogenesis protein BOP1 Heme oxygenase 2 KIAA E BOP1 8.83E HMOX2 2.65E ACSNPSFL R F8VV69;Q6 N075;Q6N Molybdate-anion transporter MFSD5 2.84E MVSTPIGGL SYVQGCTK K Oxidation (M); D6RF87;E9 PF16;Q96C M8-3;Q96CM8; Q96CM8-2 Acyl-CoA synthetase family member 2, ACSF2 8.37E ASCQPQPL ER ATAVDPTC AR GGCWPR SGEQCSVE PDLISK AAVEEGIVL GGGCALLR SWCGACK Carbamidomet hyl (C);IAAyne A0A087WT V1;E7ET92; Q9H1P3-2;Q9H1P3 Q8IY26 Q9Y4W6 Q8N201 P10809 O95881 Oxysterolbinding protein;oxystero l-binding proteinrelated protein 2 Presqualene diphosphate phosphatase AFG3-like protein 2 Integrator complex subunit 1 60 kda heat shock protein, Thioredoxin domaincontaining protein 12 OSBPL2 1.74E PPAPDC2 4.13E AFG3L2 9.53E INTS1 1.54E HSPD1 0.00E TXNDC E S287

288 CSVIRDSLL QDGEFSMD LR VLNEECDQ NWYKAELN GK Oxidation (M); K7EJ44;P J3KT38;J3Q RL5;P ;P62993 Profilin-1 PFN1 6.34E Growth factor receptor-bound protein 2 GRB2 3.20E IVQTLCTVR Q96D53;M0 R362;M0R0 L2;M0R3F7; M0R001;M0 R011 AarF domaincontaining protein kinase 4 ADCK4 5.20E LVVPASQC GSLIGK F8VXH9;H3 BRU6;F8VZ X2;B4DXP5; Q ;Q ;Q ;Q ;Q ;Q15366;Q ;F8W0G4;F 8W1G6;H3B ND9;J3QT2 7;E9PFP8;P ;P ;P ;P ;P57721 Poly(rC)-binding protein 2;Poly(rC)- binding protein 3 BP2;BP E SLDQTS PLVLVR TYAICGAIR Q6XZF7 Q8WVC2;Q 9BYK1;P Dynamin-binding protein 40S ribosomal protein S21 DNMBP 6.79E RPS E VNQAIWLLC TGAR GQKCEFQD AYVLLSEK ANFSLPEK CDYMDEVT YGELEKEE AQPIVTK EGGPNPEH NSNLANILE VCR GALMANFL TQGQVCCN GTR LTTPTYGDL NHLVSATM SGVTTCLR Oxidation (M); Carbamidomet hyl (C);IAAyne Oxidation (M); M0R0F0;M0 R0R2;P4678 2;M0QZN2 P10809 H3BQZ7;Q1 KMD3 Q9BSH4 P ;P49189 P04350;P68 371;M0R2D 3;Q5ST81;Q 5JP53;P074 37;Q9BVA1; Q S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed 60 kda heat shock protein, Heterogeneous nuclear ribonucleoprotei n U-like protein 2 Translational activator of cytochrome c oxidase 1 4- trimethylaminob utyraldehyde dehydrogenase Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta chain;tubulin beta-2b chain;tubulin beta-2a chain RPS5 2.04E HSPD1 1.11E HNRNPUL2- BSCL2;HNRN PUL2 2.58E TACO1 4.87E ALDH9A1 8.66E TUBB4A;TUB B4B;TUBB;TU BB2B;TUBB2 A 1.71E S288

289 LLQPDFQP VCASQLYP R Q9UJW0-2;Q9UJW0; Q9UJW0-3 Dynactin subunit 4 DCTN4 5.64E TVFAEHISD ECK B5MCW2;H 7C422;G5E 9G0;P39023 ;F8WCR1;H 7C3M2 60S ribosomal protein L3 RPL3 2.12E CLPPPSIR APAPAPPP SGSTSCGD RDSR CQYVTEK O15269 Q9H7N4 P04075;P ;H3BPS8;H 3BQN4;J3K PS3;P09972 Serine palmitoyltransfer ase 1 Splicing factor, arginine/serinerich 19 Fructosebisphosphate aldolase A;Fructosebisphosphate aldolase C SPTLC1 3.16E SCAF1 2.12E ALDOA;ALDO C 7.79E LTIIVSDPSH CNVLR Q5VU10;Q5 VU11;P7834 6;P Ribonuclease P protein subunit p30 RPP E YYRVCTLAII DPGDSDIIR ERLQLECQ R KAQCPIVER EDLCTKTE NLLGSYFPK LRELSFSGI EGGLR QPAIMPGQ SYGLEDGS CSYKDFSE SR E5RI99;P Q14151 M0R0F0;M0 R0R2;P Q ;Q06323;Q Q9NVG8-2;Q9NVG8 M0QYT0;M0 QXS5;P ;P S ribosomal protein L30 Scaffold attachment factor B2 40S ribosomal protein S5;40S ribosomal protein S5, N- terminally processed Proteasome activator complex subunit 1 TBC1 domain family member 13 Heterogeneous nuclear ribonucleoprotei n L RPL E SAFB2 2.57E RPS5 1.48E PSME1 3.26E TBC1D E HNRNPL 6.75E AQEPLVDG CSGGGR GQAGGGG PGTGPGLG EAGSLATC ELPLAK SCTPSPDQI SHR E7ER77;Q7 Z2K6 Q9Y3D2 C9J6P4;Q7 Z2W4-2;Q7Z2W4; Q7Z2W4-3 Endoplasmic reticulum metallopeptidas e 1 Methionine-Rsulfoxide reductase B2, Zinc finger CCCH-type antiviral protein 1 ERMP1 3.82E MSRB2 6.59E ZC3HAV1 1.21E ALLLLCGED D D6RBE9;D6 RBL5;P Annexin;Annexin A5 ANXA5 8.60E AIEDQLKEK DCALTVVAL R A0A087X0W 9;Q8N6M0-2;Q8N6M0 OTU domaincontaining protein 6B OTUD6B 8.64E S289

290 CRDDSFFG ETSHNYHK FDSEYER H0Y8T4;D6 R991;D6RE M6;A8MXP9 ;P43243 Matrin-3 MATR3 7.78E ACLISLGYD VENDRQGE AEFNR O ;O43707;F 5GXS2;O Alpha-actinin-4 ACTN4 9.37E MCLFAGFQ R QAVLGAGL PISTTTIN K Oxidation (M); Q ;Q00839 P24752;E9P KF3;H0YEL 7;P Heterogeneous nuclear ribonucleoprotei n U Acetyl-CoA acetyltransferas e, HNRNPU 3.18E ACAT1 9.66E CNNVLYIR KCSTPEEIK K P62306 P ;P60981;F6 RFD5 Small nuclear ribonucleoprotei n F SNRPF 2.56E Destrin DSTN 1.71E KPLMVIHHL EDCQYSQA LKK Oxidation (M); H7C040;B5 MC62;Q8TD 06 Anterior gradient protein 3 homolog AGR3 7.86E INAWNSPTL PIYEPGLKE VVESCR O60701;O ;E7ER83;E 7ETF4;E7E V97;E7ER9 5 UDP-glucose 6- dehydrogenase UGDH 2.34E AILIKGY DVIAQAQS GTGK J3KT04;J3K S93;J3QKZ9 ;J3QLN6;J3 KS25;J3QR 64;J3KTB5;J 3QL43;J3Q S69;J3KT12 ;P ;P60842 Eukaryotic initiation factor 4A-I EIF4A1 6.93E EAENPREV LDQVCYR AVCMLSNT TAIAEAWAR Q ;Q15459 P ;P ;P68366;P Splicing factor 3A subunit 1 Tubulin alpha- 1B chain;tubulin alpha-4a chain SF3A1 1.88E TUBA1B;TUB A4A 2.71E CLVDSAET K J3QRV5;Q6 P1M3-2;Q6P1M3 Lethal(2) giant larvae protein homolog 2 SPATS2;LLGL E YSNSDVIIY VGCGER RRCPGESLI NPGFK VIECSYTSA DGQR MLSCAGAD R P ;P38606 Q9BUH6 H0YE57;Q9 UBM7 X1WI28;P27 635;F8W7C 6;A0A087W V22;B8A6G 2;A6QRI9;H 7C123;H7C 2C5;Q96L21 V-type proton ATPase catalytic subunit A Uncharacterized protein C9orf dehydrocholeste rol reductase 60S ribosomal protein L10;60S ribosomal protein L10-like ATP6V1A 2.82E C9orf E DHCR7 9.58E RPL10;RPL10 L 7.65E S290

291 SCSGVEFS TSGHAYTD TGK TFCQLILDPI FK AILQQLGLN STCDDSILV K Q9Y277;E5 RHE1;E5RJ N6;E5RHZ6 P13639 P ;P ;P19367;P Voltagedependent anion-selective channel protein 3 VDAC3 2.20E Elongation factor EEF2 8.27E Hexokinase-1 HK1 1.03E LLDRDACD TVR K7EN20;K7 EL16;Q9NZ L4-2;Q9NZL4;Q 9NZL4-3 Hsp70-binding protein 1 HSPBP1 7.13E EALPVSLPQ ILSSFK CNLACTPP R Carbamidomet hyl (C);IAAyne E9PJ60;Q9 UHI6 F6S6P2;X6 REW1;P ;P ;P ;P46379;P Probable ATPdependent RNA helicase DDX20 Large prolinerich protein BAG6 DDX E BAG6 1.27E YLPDTLLLE ECGLLR P ;P21964;E 7EMS6 Catechol O- methyltransferas e COMT 7.54E GVAQTPGS VEEDALLC GPVSK IVDTNEM NTDTFLEEI NK Oxidation (M); Q5QPE7;Q5 QPE8;Q9BQ P7 Q8NDH3-2;Q8NDH3-5;Q8NDH3-4;Q8NDH3; H0YEP3;Q8 NDH3-3 Mitochondrial genome maintenance exonuclease 1 Probable aminopeptidase NPEPL1 MGME1 9.66E NPEPL1 0.00E ACNLTDTQ KEVK Q7LBC6-2;Q7LBC6;Q 7LBC6-3 Lysine-specific demethylase 3B KDM3B 1.85E GIMEEDEA CGR P14923;C9J PI2;K7ERP3 ;C9JTX4;C9 J826;C9JK1 8;C9JKY1 Junction plakoglobin JUP 4.62E SKEIDKCLS R CKDDEFTH LYTLIVRPD NTYEVK LALFNPDVC WDR SGGGGGG GGCGGGG GVSSLR SLVQNNCL SRPNIFLCP EIEPK Carbamidomet hyl (C);IAAyne Q14344 K7EJB9;P O00483 CON P136 45;P13645 F8VXC8;Q8 TAQ2-2;Q8TAQ2-3;Q8TAQ2 Guanine nucleotidebinding protein subunit alpha-13 GNA E Calreticulin CALR 8.10E Cytochrome c oxidase subunit NDUFA4 Keratin, type I cytoskeletal 10 SWI/SNF complex subunit SMARCC2 NDUFA4 1.17E KRT E SMARCC2 6.12E SGEEDFES LASQFSDC SSAK K7EN45;K7 EMU7;Q Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 0.00E S291

292 ADIDVSGPK VDVECPDV NIEGPEGK NALANPLY CPDYR SASLDNGG CALTTFSVL EGEKNNHR Q09666 H3BP04;H3 BSJ9;H3BR G4;P22695 B1APM4;P ;P ;P35610 Neuroblast differentiationassociated protein AHNAK Cytochrome b- c1 complex subunit 2, Sterol O- acyltransferase 1 AHNAK 4.33E UQCRC2 1.36E SOAT1 1.25E DLVTQQLP HLMPSNCG LEEK ERICSEEER Oxidation (M); Q9HCY8 Protein S100- A14 C9JRZ6;F8 WAR4;Q9N X63 MICOS complex subunit MIC19 S100A E CHCHD3 3.53E DSFKQSLE SLSSGLCK IMKDLDQC RDGK QGEYGLASI CNGGGGAS AMLIQKL STLTDSLVC K ANFSLPEK CDYMDEVT YGELEKEE AQPIVTK ALDVGSGS GILTACFAR QIPAITCIQS QWR KPNVGCQQ DSEELLK GCEVVVSG K Q7LBC6-2;Q7LBC6 Lysine-specific demethylase 3B C9J0F2;A0A 0A0MRJ6;H 7BY58;P220 61;P P46940;H0Y LE8 Ras GTPaseactivating-like protein IQGAP1 A0AVT1-3;A0AVT1 P23396;P ;H0YEU2;E 9PL09;E9PJ N9;E9PSF4 2 Protein-Lisoaspartate O- methyltransferas e;protein-lisoaspartate(daspartate) O- methyltransferas e Ubiquitin-like modifieractivating enzyme 6 40S ribosomal protein S3 KDM3B 4.96E S100A E ACAT1 7.44E EEF2 4.54E P60903 Protein S100- A10 P24752 Acetyl-CoA acetyltransferas e, P13639 Elongation factor 2 H3BQZ7;Q1 Heterogeneous KMD3 nuclear ribonucleoprotei n U-like protein HNRNPUL2- BSCL2;HNRN PUL2 2.58E MT1 1.82E IQGAP1 3.63E UBA6 4.19E RPS3 7.48E KCTSGGYY R S4R3D6;Q9 6GX9-3;Q96GX9 Methylthioribulos e-1-phosphate dehydratase APIP 1.30E TYDPSGDS TLPTCSK GVPGAIVNV SSQCSQR Q9Y2X3 J3KS22;J3Q S36;Q7Z4W 1;J3QS45;J 3KRZ4;J3K SZ5;J3QL34 Nucleolar protein 58 L-xylulose reductase NOP E DCXR 1.52E S292

293 AVFPEG EEPLQLR F5GWN4;F8 WBT0;A0A0 A0MSJ2;E7 EU13;Q96P 48-5;Q96P48-7;Q96P48-2;Q96P48-4;Q96P48-1;Q96P48-3;Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domaincontaining protein 1 ARAP1 2.01E KGDECELL GHSK GEETPVIVG SALCALEG RDPELGLK YSNSALGH VNCTIK P49411 P49411 H7C106;F8 W914;Q9NQ C3-3;Q9NQC3-2;Q9NQC3-5;Q9NQC3-4;Q9NQC3-6;Q9NQC3 Elongation factor Tu, Elongation factor Tu, Reticulon;Reticul on-4 TUFM 5.40E TUFM 1.38E RTN4 6.68E DINAYNCEE PTEKLPFPII DDR VKGDADVS VPKLEGDLT GPSVGVEV PDVELECP DAK KLLDLVQQ SCNYK IINDNATYC R CNEQPNRV EIYEK P30041 Peroxiredoxin-6 PRDX6 4.98E Q09666 B1AHD1;P O00567;Q5J XT2 A0A087WT Q3;A0A087 WWZ1;E7E VJ5;Q96F07-2;Q7L576;Q 96F07;A0A0 87WU52;A0 A087WWL1; A0A087WV E1;H7C229 Neuroblast differentiationassociated protein AHNAK NHP2-like protein 1;NHP2- like protein 1, N- terminally processed Nucleolar protein 56 Cytoplasmic FMR1- interacting protein 2;Cytoplasmic FMR1- interacting protein 1 AHNAK 9.26E NHP2L1 5.41E NOP E CYFIP2;CYFI P1 1.59E CQLQQAAA LNAQHK ACYGVLR Q96DF8 Protein DGCR14 DGCR E P23396;P ;H0YEU2;E 9PL09 40S ribosomal protein S3 RPS3 5.68E KQESSCPS QNLK Q8NEU8-2;Q8NEU8; Q8NEU8-3 DCC-interacting protein 13-beta APPL2 9.78E VTINDLNEN SVTLIQENC HLNK Q7Z2T5-2;Q7Z2T5 TRMT1-like protein TRMT1L 3.65E S293

294 TLLVNCQN K Q8TC07-2;Q8TC07;F 8VV61;C9JA 93;Q8TC07-3 TBC1 domain family member 15 TBC1D E MYGAQEDG SVGEGDLS CILK TSDANETE DHLESLICK QYLSTPDS QSLRCDLIR Q8NF37 F2Z2T1;Q A0A096LN W8;Q68E01-3;Q68E01-2;Q68E01 Lysophosphatidy lcholine acyltransferase 1 Nuclear capbinding protein subunit 1 Integrator complex subunit 3 LAT1 5.61E NCBP1 2.25E INTS3 6.42E AAADGDRD CVLQK VQAQYPGV CINNEVVEP SAEQIAK CPGESLINP GFK QELSHALY QHDAACR QSACNLEK K QLSSSVTG LTNIEEENC QR QRNPMDYP VEDAFCKP QLVK EMQNLSFQ DCYSSK GVCDQSFG IHVAELANF PK QVLVAPGN AGTACSEK ALDLDSSC K Q96D53;Q9 6D53-2 P50135 Histamine N- methyltransferas e Q9BUH6 Q9UMS4;F5 GY56;F5H2I 0 P35579;P P46940 Q8NFJ5 P30084 E9PHA6;P ;P43246 C9JZG2;C9 JKQ7;C9JBJ 1;C9JTV6;F 8WD69;P ;P22102 P ;P31948;P ;H0YGI8 AarF domaincontaining protein kinase 4 Uncharacterized protein C9orf142 Pre-mRNAprocessing factor 19 ADCK4 1.15E HNMT 4.18E C9orf E PRPF E Myosin-9 MYH9 7.54E Ras GTPaseactivating-like protein IQGAP1 Retinoic acidinduced protein 3 Enoyl-CoA hydratase, DNA mismatch repair protein Msh2 Trifunctional purine biosynthetic protein adenosine- 3;Phosphoribosy lamine--glycine ligase;phosphori bosylformylglyci namidine cycloligase;phosphori bosylglycinamid e formyltransferas e Stress-inducedphosphoprotein 1 IQGAP1 6.45E GPRC5A 8.65E ECHS1 2.30E MSH2 2.06E GART 2.77E STIP1 1.36E SGIQPLCPE R QKQYNCLT QR P42166 Q9Y3A2 Laminaassociated polypeptide 2, isoform alpha;thymopoi etin;thymopenti n Probable U3 small nucleolar RNA-associated protein 11 TMPO 4.59E UTP11L 7.21E S294

295 AFGGPGAG CISEGR QPAIMPGQ SYGLEDGS CSYKDFSE SR Oxidation (M); Q9H479 M0QYT0;M0 QXS5;P ;P14866 Fructosamine-3- kinase Heterogeneous nuclear ribonucleoprotei n L FN3K 2.99E HNRNPL 6.75E AAGPLLTDE CR NPLNLQ K YLEKEEKCL PPPSIR LKPDPEPD DKNQEPSS CK Q9BQ69 Q ;Q92754 O15269 H3BNK9;H3 BU93;Q9GZ U8 O-acetyl-ADPribose deacetylase MACROD1 Transcription factor AP-2 gamma Serine palmitoyltransfer ase 1 Protein FAM192A MACROD1 1.45E TFAP2C 7.16E SPTLC1 4.83E FAM192A 9.26E ICIDKGLTD ESEILR Q8IV36-3;Q8IV36-2;Q8IV36 Protein HID1 HID1 1.43E LKESAQCV GDEFLNCK GFGHIGIAV PDVYSACK DCLADVDT KPAYQNLR SLLINAVEA SCIR Carbamidomet hyl (C);IAAyne C9J8E6;C9J 014;C9J271; Q9Y5X2 Q ;Q04760 Q8NFC6;Q9 6IK1-2;Q96IK1 J3QKT4;A0 A087WTV6; E2QRB3;A0 A087WZR9; J3KR12;P ;P32322;Q 96C36;P Sorting nexin-8 SNX8 3.82E Lactoylglutathion e lyase Biorientation of chromosomes in cell division protein 1-like 1;Biorientation of chromosomes in cell division protein 1 Pyrroline-5- carboxylate reductase;pyrroli ne-5-carboxylate reductase 1, ;Py rroline-5- carboxylate reductase 2 GLO1 5.62E BOD1L1;BOD 1 PYCR1;PYCR E E GSQMGTVQ PILLSMP TR 2 Oxidation (M); Q9NZB2;Q9 NZB2-6;Q9NZB2-2;Q9NZB2-5;Q9NZB2-4 Constitutive coactivator of PPAR-gammalike protein 1 FAM120A 6.39E LLAPDCEIIQ EVGK LEGDLTGP SVDVEVPD VELECPDA K AVQALCAV YEHWVPR Q9NQT5 Q09666 O60701;O ;O Exosome complex component RRP40 Neuroblast differentiationassociated protein AHNAK UDP-glucose 6- dehydrogenase EXOSC3 2.04E AHNAK 2.16E UGDH 7.49E SWCPDCVQ AEPVVR RNCWPR Carbamidomet hyl (C);IAAyne I3L0K2;I3L3 M7;Q9BRA2 E9PP36;E9 PKZ0;E9PK U4;P62917 Thioredoxin domaincontaining protein 17 60S ribosomal protein L8 TXNDC E RPL8 5.72E S295

296 CQLPDGSF R IRESIQEDL AEEALQ GGR VIEDVAFAC ALTSSVPTT K AQCPIVER LGNNCVFA PADVTSEK DVQTALALA K NMACVQR O75643;O O ;O15357;H 7BXR2 Q ;Q14527 M0R0F0;M0 R0R2;P Q ;Q99714;Q 5H928 X6RJP6;P37 802;P U5 small nuclear ribonucleoprotei n 200 kda helicase SNRNP E Phosphatidylino INPPL1 3.69E sitol 3,4,5- trisphosphate 5- phosphatase 2 Helicase-like HLTF 1.74E transcription factor 40S ribosomal RPS5 1.33E protein S5;40S ribosomal protein S5, N- terminally processed 3-hydroxyacyl- HSD17B E CoA dehydrogenase type-2 Transgelin-2 TAGLN2 2.54E LQAFSAAIE SCNK KRAGDELA YNSSSACA SSR IGNCPFSQ R GSQMGTVQ PILLSMP TR Oxidation (M); Q02790 Q86Y37-4;Q86Y37 O00299 Q9NZB2;Q9 NZB2-6;Q9NZB2-2;Q9NZB2-5;Q9NZB2-4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidylprolyl cis-trans isomerase FKBP4, N- terminally processed CDK2- associated and cullin domaincontaining protein 1 Chloride intracellular channel protein 1 Constitutive coactivator of PPAR-gammalike protein 1 FKBP4 3.77E CACUL1 1.55E CLIC1 2.11E FAM120A 6.39E YIGENLQLL VDRPDGTY CFR YCPNSVLVII DVKPK RTDPECTA PIKK VTAVIFP YAR J3QLW7;Q9 Y221-2;Q9Y221 H3BNT7;H3 BTM8;P Q5T7F5;Q8 N1G2 A6NMS2;B1 ALA7;D3YT J7;B1ALA9; P ;P60891;P 21108;P119 08;P S ribosome subunit biogenesis protein NIP7 homolog 26S proteasome non-atpase regulatory subunit 7 Cap-specific mrna (nucleoside-2'- O-)- methyltransferas e 1 Ribosephosphate pyrophosphokin ase 1;Ribosephosphate pyrophosphokin ase 3;Ribosephosphate pyrophosphokin ase 2 NIP7 4.13E PSMD7 5.67E CMTR1 4.05E PRPS2;PRPS 1;PRPS1L1 6.51E S296

297 GLCAIAQAE SLR P23396;P ;F2Z2S8;H 0YF32;H0Y CJ7 40S ribosomal protein S3 RPS3 3.54E KACGDSTL TQITAGLDP VGR VCNFLASQ VPFPSR EAEEEEAS CLLGPTLK P62879;C9J IS1;C9JXA5; C9JZN1 Q ;Q99714 H3BLU1;Q4 KMQ1-2;Q4KMQ1-4;Q4KMQ1-3;Q4KMQ1 Guanine nucleotidebinding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 1.71E hydroxyacyl- HSD17B E CoA dehydrogenase type-2 Taperin TPRN 4.93E FLDGNELTL ADCNLLPK QMEKDETV SDCSPHIAN IGR Oxidation (M); O00299 B1AK87;B1 AK85;B1AK 88;P ;P47756 Chloride intracellular channel protein 1 F-actin-capping protein subunit beta CLIC1 4.35E CAPZB 3.84E RVAYDK TALALEVGD IVK LFACEEHP SHK VVVVDDLLA TGGTMNAA CELLGR GTCADRDN LTRR IVIVGDGGC GK LIDFLECGK P46109 Crk-like protein CRKL 2.09E Q9UL15;Q9 UL15-2 H3BQZ9;P D6RHU3;P Q9HBH0;F5 GXB1;Q9HB H0-2 J3KTA4;P ;P17844;J3 QSF1;J3KR Z1 BAG family molecular chaperone regulator 5 Adenine phosphoribosyltr ansferase Caspase- 6;Caspase-6 subunit p18;caspase-6 subunit p11 Rho-related GTP-binding protein RhoF Probable ATPdependent RNA helicase DDX5 BAG5 4.01E APRT 2.78E CASP6 7.60E RHOF 2.64E DDX5 4.71E DSKCEYPA ACNALETLL IHR FGAGGGAA GAVLGIDNV CELAAR KITIADCGQ LE Carbamidomet hyl (C);IAAyne P ;P54886 P10588;M0 R175 P62937;P Delta-1- pyrroline-5- carboxylate synthase;glutam ate 5- kinase;gammaglutamyl phosphate reductase Nuclear receptor subfamily 2 group F member 6 Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N- terminally processed ALDH18A1 4.04E NR2F6 5.62E PPIA 4.55E S297

298 ANSSVVSV NCK ATYDKLCK NCPHIVVGT PGR O ;O ;O ;O60502 P62851 F6S4E6;A0 A0A0MT12; F6TRA5;F6 UJC5;F6WL T2;Q5STU3; Q13838;Q Bifunctional protein NCOAT;Protein O- GlcNAcase;Hist one acetyltransferas e 40S ribosomal protein S25 Spliceosome RNA helicase DDX39B MGEA5 2.31E RPS E DDX39B 9.21E SEFYANEA CKR G3V4F2;A0 A087X0W7; A0A087WT9 5;P ;Q86TX2;P Acyl-coenzyme A thioesterase 2, ;Ac yl-coenzyme A thioesterase 1 ACOT1;ACOT E SAVDLSCS RR Q9Y446;Q9 Y446-2;E9PK71 Plakophilin-3 PKP3 9.90E RELHGQNP VVTNK F8WJN3;Q ;Q16630;Q Cleavage and polyadenylation specificity factor subunit 6 CPSF6 7.88E QLCEDWEV VPEPVAR D6RCP9;D6 RFG8;P Deoxycytidine kinase DCK 1.62E VGILDVDLC GPSIPR Q9Y5Y2;H3 BNF0;H3BN S4 Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 2.98E TVEICPFSF DSR ICDECNYG SYQGR SGAELALD YLCR Carbamidomet hyl (C);IAAyne Q9ULW0;Q9 ULW0-2 Q7RTV0 H7C0T1;H7 C2R9;C9JQ V0;Q9BRJ6 Targeting protein for Xklp2 PHD finger-like domaincontaining protein 5A Uncharacterized protein C7orf50 TPX2 4.55E PHF5A 5.18E C7orf E SVDGSPTT AFTVLECE GSRR M0R0S2;M0 QZF4;M0R2 P6;Q8TBC3 SH3KBP1- binding protein 1 SHKBP1 9.72E CDVDIRK KGVCDQSF GIHVAELAN FPK P60709;P63 261;Q562R1 E9PHA6;P ;P43246 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;betaactin-like protein 2 DNA mismatch repair protein Msh2 ACTB;ACTG1; ACTBL2 3.19E MSH2 5.58E SGRYEAAF PFLSGR ER H0YF29;Q6 P1X6-2;Q6P1X6 UPF0598 protein C8orf82 C8orf E S298

299 SCSSSCAV HDLIFWR Carbamidomet hyl (C);IAAyne B7Z4M1;O ;O ;O Reticulon RTN3 1.69E DICACAATG TGK ETIGVGSYS ECKR Carbamidomet hyl (C);IAAyne A0A087X05 9;B7Z6D5;Q 96GQ7 E9PRI4;E9P GT3;Q ;Q15418;Q Probable ATPdependent RNA helicase DDX27 Ribosomal protein S6 kinase;ribosom al protein S6 kinase alpha-1 DDX E RPS6KA1 1.77E AINCATSGV VGLVNCLR FTLPGSGT EGPAKQEN FILGSCGTD QVK Carbamidomet hyl (C);IAAyne P49327 K7EMJ5;K7 ERP1;K7EP S3;Q9GZN7 Fatty acid synthase;[acylcarrier-protein] S- acetyltransferas e;[acyl-carrierprotein] S- malonyltransfera se;3-oxoacyl- [acyl-carrierprotein] synthase;3- oxoacyl-[acylcarrier-protein] reductase;3- hydroxyacyl- [acyl-carrierprotein] dehydratase;en oyl-[acyl-carrierprotein] reductase;oleoyl -[acyl-carrierprotein] hydrolase Protein rogdi homolog FASN 2.39E ROGDI 2.39E YLTCPK Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149 Plectin PLEC 1.80E SGRYEAAF PFLSGR H0YF29;Q6 P1X6-2;Q6P1X6 UPF0598 protein C8orf82 C8orf E LLMEQESS ACSR LCYSSDHE K ESPVSAPLE GLICR O ;O96011 P21266;A0A 0A0MTN3 O ;O75376;A 0A088AWL3 Peroxisomal membrane protein 11B Glutathione S- transferase Mu 3 Nuclear receptor corepressor 1 PEX11B 8.86E GSTM3 7.74E NCOR1 1.75E AGCALSAE SSR LILDVFCGS QMHFVR Q96HP0;K7 ESB7 P11413;P ;P Dedicator of cytokinesis protein 6 Glucose-6- phosphate 1- dehydrogenase DOCK6 3.79E G6PD 1.53E S299

300 SEVEEVDF AGWLCK FICTTSAIQ NR M0R1B6;G5 E9C7;P K7ESG8;P ;P ;P53396 Dual specificity mitogenactivated protein kinase kinase 2 ATP-citrate synthase MAP2K2 3.48E ACLY 1.02E APPPSLTD CIGTVDSR EVCGFAPY ER DSAQCAAIA ER Q9NZZ3-2;Q9NZZ3 J3QSB5;Q9 Y3U8 Q96RS6-3;Q96RS6-2;Q96RS6 Charged multivesicular body protein 5 60S ribosomal protein L36 NudC domaincontaining protein 1 CHMP5 3.63E RPL E NUDCD1 4.16E CLEELQKR P49721;A0A 087WVV1 Proteasome subunit beta type-2 PSMB2 8.57E GLCESVVE ADLVEALEK C9JJZ7;H7B XH8;B7WP G3;C9IYN3; D6W592;Q8 WVV9-3;Q8WVV9-2;Q8WVV9-5;Q8WVV9-4;Q8WVV9 Heterogeneous nuclear ribonucleoprotei n L-like HNRNPLL;HN RPLL 2.32E NCTAGAVY TYHEK M0R1T7;M0 QX85;M0R1 K2;M0R3B2; A0A075B6F 9;Q9Y314 Nitric oxide synthaseinteracting protein NOSIP 2.36E GIGMNEPL VDCEGYPR F5H7X1;F5 H5V4;F5GX 23;J3KN29; O ;O S proteasome non-atpase regulatory subunit 9 PSMD9 6.43E YIASEVCED SITVGMVR LVILANNCP ALR F8WE91;Q9 Y6K1-2;Q9Y6K1 E5RI99;P62 888;E5RJH3 DNA (cytosine- 5)- methyltransferas e 3A 60S ribosomal protein L30 DNMT3A 7.84E RPL E AAAGEFAD DSSVK G3XAM7;P3 5221;P ;E5RHV7;E 5RGY6;E5R G03;E5RJ41 ;E5RIB1 Catenin alpha-1 CTNNA1 5.13E DCPHISQR TLETANCM SSQTK B4DEM9;Q9 Y2S7 P ;P50416;H 3BP22;H3B UV7 Polymerase delta-interacting protein 2 Carnitine O- palmitoyltransfer ase 1, liver isoform POLDIP2 8.76E CPT1A 4.64E CIPALDSLT PANEDQK VGLSGAPA DACSTAQK P kda heat shock protein, Q8NFW8 N- acylneuraminate cytidylyltransfera se HSPD1 1.47E CMAS 3.29E S300

301 LTAIDILTTC AADIQR SGQGAFGN MCR Oxidation (M); O75643;B4E 0P5 P36578;H3B TP7;H3BU3 1 U5 small nuclear ribonucleoprotei n 200 kda helicase 60S ribosomal protein L4 SNRNP E RPL4 2.81E KPAFTEAS CPLSR O ;O15357;A 0A0A0MTP6 Phosphatidylino sitol 3,4,5- trisphosphate 5- phosphatase 2 INPPL1 5.07E GLATFCLDK CLIATGGTP R U3KQM0;O0 0264;O1517 3;O O ;O ;O ;O95831 Membraneassociated progesterone receptor component 1;Membraneassociated progesterone receptor component 2 Apoptosisinducing factor 1, PGRMC2;PG RMC1 1.09E AIFM1 1.86E RPVFPPLC GDGLLSGK EETR IRPLNSEGT LNLLNCEPP R KNILEESLC ELVAK VRCGLEHE R DLDQCRDG K CCSGAIIVL TK AVLLVGLCD SGK LQLECQR KGTVLLAD NVICPGAPD FLAHVR VFEAEQFG CPQR STFQAHLA PVVCPK FRISLGLPV GAVINCAD NTGAK IEDEECVRL DKER QVFTNAEV YNCR DLGGIVLAN ACGIGQ WDRK Carbamidomet hyl (C);IAAyne Carbamidomet hyl (C);IAAyne F8WBJ6;Q9 NRX1 Q9Y5S2 P ;P78527 Q9Y3X0 RNA-binding protein PNO1 Serine/threonine -protein kinase MRCK beta DNA-dependent protein kinase catalytic subunit Coiled-coil domaincontaining protein 9 P60903 Protein S100- A10 B4DNK4;P1 Pyruvate 4618;P1461 kinase;pyruvate 8-3 kinase PKM Q9Y5M8;C9 J5Z8 Q14151 P ;P21964 Q8NFG4-2;Q8NFG4 J3KT25;Q9P 2X3-2;Q9P2X3 P62829;C9J D32;B9ZVP 7;J3KT29 PNO1 9.25E CDC42BPB 4.63E PRKDC 7.52E CCDC9 1.54E S100A E PKM 3.29E Signal recognition particle receptor subunit beta SRPRB 4.42E Scaffold SAFB2 1.37E attachment factor B2 Catechol O- COMT 1.36E methyltransferas e Folliculin FLCN 2.07E Protein IMPACT IMPACT 3.17E S ribosomal protein L23 RPL E Q6P1J9 Parafibromin CDC E Q9UIG0-2;Q9UIG0 A2A274;Q Tyrosine-protein kinase BAZ1B Aconitate hydratase, BAZ1B 1.89E ACO2 6.21E S301

302 DSLYVDGD CTMDIR C9J712;C9J 0J7;C9JQ45 ;C9J2N0;G5 E9Q6;P ;P35080 Profilin;Profilin-2 PFN2 8.19E LLEPEAPGL CRPPLPR H0Y8L4;A8 MQ02;J3KN 01;P ;P55196;P Afadin MLLT4 3.89E IGSSLYALG TQDSTDICK EVLCPESQ SPNGVR EQVPSLGS NVACGLAY TDYHK SLRECELYV QK QITSYGETC PGLEQYAIK K A0A0A0MRI 2;Q9UNH7-2;Q9UNH7 Q ;Q14684 M0R026;A1 L0T0 K7EPR5;K7 EQK3;K7EM U2;X6RAV4; K7EMZ6;K7 EIE5;K7EID 3;K7EJ40;K 7EK41;K7E PB2;P ;P10644 P ;P50990;P Sorting nexin- 6;Sorting nexin- 6, N-terminally processed Ribosomal RNA processing protein 1 homolog B Acetolactate synthase-like protein campdependent protein kinase type I-alpha regulatory subunit;campdependent protein kinase type I-alpha regulatory subunit, N- terminally processed T-complex protein 1 subunit theta SNX6 1.25E RRP1B 3.99E ILVBL 6.99E PRKAR1A 2.59E CCT8 8.86E LEGIPAYIVV PQTAPDCK K ICDQWDAL GSLTHSR I3L4B4;Q9G ZT4 O ;O43707;F 5GXS2;O Serine racemase SRR 2.93E Alpha-actinin-4 ACTN4 3.76E ELCALHALN NVFQDSNA FTR B0QY58;B0 QY55;B0QY 57;B0QY56; H0YGT9;Q Josephin-1 JOSD1 8.35E SLCLGPALI HTAK DLAACIK GQVPSGAT GSSTCPK CYQLPPGA R Q ;Q ;Q99643 O75874 Succinate dehydrogenase cytochrome b560 subunit, Isocitrate dehydrogenase [NADP] cytoplasmic SDHC 5.15E IDH1 5.28E F8VWL3 FGD4 3.05E P13716;P Deltaaminolevulinic acid dehydratase ALAD 3.98E S302

303 IVDTNEM NTDTFLEEI NKVGK Oxidation (M); Q8NDH3-2;Q8NDH3-5;Q8NDH3-4;Q8NDH3; H0YEP3;Q8 NDH3-3 Probable aminopeptidase NPEPL1 NPEPL1 1.00E QRPGSDEC LR MVSTPIGGL SYVQGCTK Oxidation (M); Q9UM82 D6RF87;E9 PF16;Q96C M8-3;Q96CM8; Q96CM8-2 Spermatogenesi s-associated protein 2 Acyl-CoA synthetase family member 2, SPATA2 8.55E ACSF2 6.24E SDFGSCPP EEQPR ALNALCDG LIDELNQAL K QVASHVGL HSASIPGIL ALDLCPSDT NK AGLENTVA ETECR Q8WZ82 P30084 Q9UMS4;F5 GY56 K7ERE3;CO N ENSEM BL:ENSP ; CON P ;P ;P13646 Ovarian cancerassociated gene 2 protein Enoyl-CoA hydratase, Pre-mRNAprocessing factor 19 Keratin, type I cytoskeletal 13 OVCA2 1.23E ECHS1 0.00E PRPF E KRT E SVVCSDVE QQVIVIEEE KK SSTETCYS AIPK Q7L014 E7EN95;O ;O ;O ;O ;O ;O75369;O ;A0A0A0M T44 Probable ATPdependent RNA helicase DDX46 DDX E Filamin-B FLNB 2.27E CEYPAACN ALETLLIHR SSGCDVNL PGVNVK AEGLATGF CR Carbamidomet hyl (C);IAAyne P ;P54886 Q09666 C9J9N8;C9J EX8;C9IYN7 ;Q0PNE2-2;Q0PNE2 Delta-1- pyrroline-5- carboxylate synthase;glutam ate 5- kinase;gammaglutamyl phosphate reductase Neuroblast differentiationassociated protein AHNAK Elongator complex protein 6 ALDH18A1 7.47E AHNAK 2.66E ELP6 4.61E YCDPDSYH RR K7ENG2;P ;P26368 Splicing factor U2AF 65 kda subunit U2AF2 8.32E ECADLWPR P62829;J3K TJ3 60S ribosomal protein L23 RPL E S303

304 DLGPTLLVH GVTPVTCT DL CLSAAEEK Q9BXP2 Solute carrier family 12 member 9 Q5VU61;A0A087WWU8;Q5VU5 9;P ;J3KN67;P ;P SLC12A9 6.87E TPM3 1.87E EQIDNLATE LCR GTCVEGTIP K NLADCLR GPFVEAEV PDVDLECP DAK SYCNDQST GDIK VPTANVSV VDLTCR O95295 H3BND8;Q ;Q93009;F 5H2X1 P49721 Q09666 P00492 E7EUT5;P ;P04406 SNAREassociated protein Snapin Ubiquitin carboxylterminal hydrolase;ubiqui tin carboxylterminal hydrolase 7 Proteasome subunit beta type-2 Neuroblast differentiationassociated protein AHNAK Hypoxanthineguanine phosphoribosyltr ansferase Glyceraldehyde- 3-phosphate dehydrogenase SNAPIN 2.01E USP7 5.68E PSMB2 2.36E AHNAK 0.00E HPRT1 2.10E GAPDH 1.53E FLGCVDIKD LPVSEQQE R H0YD73;E9 PL38;J3KN Q3;A0A087 WUL9;Q9U NM6;Q9UN M6-2 26S proteasome non-atpase regulatory subunit 13 PSMD E CQLEINFNT LQTK O ;O43707;H 9KV75;P ;P12814;P ;P ;K7EJH8;P ;F6THM6;A 0A087WSZ2 ;P35609;Q Alpha-actinin- 4;Alpha-actinin- 1;Alpha-actinin- 2;Alpha-actinin-3 ACTN4;ACTN 1;ACTN2;ACT N3 1.84E DIRPVCR K7EQN7;B1 Q2N1;O ;O00148 ATP-dependent RNA helicase DDX39A DDX39A;DDX E GDECGLAL GR P ;P54886 Delta-1- pyrroline-5- carboxylate synthase;glutam ate 5- kinase;gammaglutamyl phosphate reductase ALDH18A1 1.48E S304

305 STCSLTPAL AAHFSENLI K A0A0A0MR T2;Q9BTA9-5;Q9BTA9-2;Q9BTA9 WW domaincontaining adapter protein with coiled-coil WAC 8.08E KACADATL SQITNNIDP VGR LLGSTIPLC SAQWER LDVGNFSW GSECCTR LIPGCEVILA TPYGR GSCSTEVE KETQEK LEGDLTGP SVGVEVPD VELECPDA K FTSGAFLSP SVSVQECR YINENLIVNT DELGRDCLI NAAK SQQSKPQD ASCLPALK CESAFLSK IYFGSNIPN MFVDSSCA LK EGCTEVSLL R AVCMLSNT TAVAEAWA R QEASKPPR GCPQANR CPDYYENN VHK KAADETLC QTK YLLADCNE AFIK DINAYNCEE PTEKLPFPII DDRNR Carbamidomet hyl (C);IAAyne Oxidation (M); Oxidation (M); P ;P62873;B 1AKQ8;F6U T28 P ;P50416;H 3BMD2 P62241 Guanine nucleotidebinding protein G(I)/G(S)/G(T) subunit beta-1 Carnitine O- palmitoyltransfer ase 1, liver isoform 40S ribosomal protein S8 GNB1 9.57E CPT1A 2.66E RPS8 2.34E R4GNB2;R4GN35 DENND4C 1.04E O75348 Q09666 H7C3P6;P ;P ;P ;P52948 E7ERF2;P1 7987;F5H7Y 1;F5H136 H0Y4F7;A0 A0A0MRX9; Q5JRX3-3;Q5JRX3;Q 5JRX3-2 C9JXB8;C9J NW5;P V-type proton ATPase subunit G 1 Neuroblast differentiationassociated protein AHNAK Nuclear pore complex protein Nup98- Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 T-complex protein 1 subunit alpha Presequence protease, 60S ribosomal protein L24 ATP6V1G1 1.20E AHNAK 0.00E NUP E TCP1 1.20E PITRM1 6.44E RPL E O75477 Erlin-1 ERLIN1 1.30E H3BQZ7;Q1 KMD3 F5H5D3;Q9 BQE3 Q8IVT2 Q9H9F9 P ;P49916 O60216;E5 RJW1;E5RJ K5;E5RFV8; E5RIN7 Heterogeneous nuclear ribonucleoprotei n U-like protein 2 Tubulin alpha- 1C chain HNRNPUL2- BSCL2;HNRN PUL2 1.64E TUBA1C 1.76E Mitotic interactor and substrate of PLK1 MISP 3.75E Actin-related ACTR5 2.34E protein 5 DNA ligase 3 LIG3 4.78E Double-strandbreak repair protein rad21 homolog RAD E P30041 Peroxiredoxin-6 PRDX6 1.18E S305

306 VLVVSVCP QSLPYFAA K J3QL28;J3Q SD9;J3KTP 5;J3QRB0;J 3KRH7;J3K S48;J3KT43 ;E9PH27;E7 EP87;A0A08 8AWN8;Q9 UHQ1-4;Q9UHQ1-3;Q9UHQ1; Q9UHQ1-2 Nuclear prelamin A recognition factor NARF 6.34E GKEFEFSQ LPLKVEFLE CSAK LLGGFQET CSK SVSSNV ESR Q9Y5M8;H7 C4H2 Q9BVP2-2;Q9BVP2 I3L182;I3L4 D8;Q9UQ35-2;Q9UQ35 Signal recognition particle receptor subunit beta Guanine nucleotidebinding proteinlike 3 Serine/arginine repetitive matrix protein 2 SRPRB 1.32E GNL3 1.10E SRRM2 1.69E AICIDPAYS K LQAQVECS HSSQQR K7EMD6;O Small glutaminerich tetratricopeptide repeatcontaining protein alpha Golgin subfamily A member 3 Q ;Q ;Q08378 SGTA 4.54E GOLGA3 2.06E GQVCLPVIS AENWKPAT K P ;P68036;P Ubiquitinconjugating enzyme E2 L3 UBE2L3 4.61E VQYPQSQA CK TAVCDIPPR ACFQVGTS EEMK Oxidation (M); Q14204 P04350;P68 371;Q5ST81 ;Q5JP53;P0 7437;Q9BV A1;Q13885;I 3L2F9;A6N NZ2;A0A075 B736;Q5SQ Y0;Q3ZCM7 A0A0A0MS W3;P ;P ;P35658;P ;P Cytoplasmic dynein 1 heavy chain 1 Tubulin beta-4a chain;tubulin beta-4b chain;tubulin beta chain;tubulin beta-2b chain;tubulin beta-2a chain;tubulin beta-8 chain-like protein LOC260334;Tub ulin beta-8 chain Nuclear pore complex protein Nup214 DYNC1H1 4.40E TUBB4A;TUB B4B;TUBB;TU BB2B;TUBB2 A;TUBB8 9.47E NUP E AVTNHSVY CSTK J3KS22;J3Q S36;Q7Z4W 1;J3QS45;J 3KRZ4;J3K SZ5;J3QL34 L-xylulose reductase DCXR 5.41E SKTSNKPL MIIHHLDEC PHSQALK C9J3E2;B5 MC07;O Anterior gradient protein 2 homolog AGR2 1.25E S306

307 VAVTEGCQ PSR E7EN95;O ;O ;O ;O ;O ;O75369;O ;O ;O Filamin-B FLNB 3.29E ITTFPPVPV TCDAVR Q86VL0;Q5 JRI7;A0A0A 0MT58;Q ;Q15560 Transcription elongation factor A protein 2 TCEA2 4.65E SCYDLSCH AR ACVGNAYH K CANVNNSS TTSQR KEGITGPPA DSSKPIGPD DAIDALSSD FTCGSPTA AGK Carbamidomet hyl (C);IAAyne P41250 Q9UKX7-2;Q9UKX7 Glycine--tRNA ligase Nuclear pore complex protein Nup50 GARS 2.68E NUP E R4GNB2;R4GN35 DENND4C 2.40E E9PDE4;E7 ES10;E7EV Y3;B7Z574; P ;P ;P20810;P ;P ;P ;P ;H0YA91 Calpastatin CAST 1.56E TPSYSISST LNPQAPEFI LGCTASK Q14694;Q ;Q ;H3BQC6 Ubiquitin carboxylterminal hydrolase 10 USP E DCGGAAQL AGPAAEAD PLGR A0A096LNT 1;A0A096LN N8;A0A096L PF9;A0A096 LNV3;A0A0 96LP02;Q9Y 508-2;Q9Y508 E3 ubiquitinprotein ligase RNF114 RNF E TAELLNACK CALSSPSLA FTPPIK Q6PI48 Q8NFH5-3;Q8NFH5-2;Q8NFH5 Aspartate--tRNA ligase, Nucleoporin NUP53 DARS2 5.30E NUP E GKLVDCK VLMSVQYF LEDVDCK IICQGFTGK P35270 C9K0E3;Q0 5655;Q P53597;H7C 233 Sepiapterin reductase Protein kinase C delta type;protein kinase C delta type regulatory subunit;protein kinase C delta type catalytic subunit Succinyl-CoA ligase [ADP/GDPforming] subunit SPR 2.65E PRKCD 1.50E SUCLG1 4.14E S307

308 alpha, ELCELKPK SSPGNKDK EASR E9PIZ4;E9P SD5;E9PPQ 5;Q9UHD1-2;Q9UHD1 H0Y704;O ;O ;O ;O15231;O ;O ;O ;H7BZT5;H 7C1R1 Cysteine and histidine-rich domaincontaining protein 1 Zinc finger protein 185 CHORDC1 2.42E ZNF E LLAVNNVCL EEVTHEEA VTALK H7C166;B4 E2H8;E7EQ D7;Q ;Q ;Q ;Q ;Q ;Q ;Q12959;Q ;Q Disks large homolog 1 DLG1 5.59E KPGSTP YSER H0Y704;O ;O ;O ;O15231;O ;O ;O ;O ;O Zinc finger protein 185 ZNF E LCVQNSHQ EAR CGIPEALVQ R MKLNISFPA TGCQK LVMSYVAA VCGK Oxidation (M); Q9H0L4 A0A087WW 74;O94885 P62753;A2A 3R7 C9JUP5;C9 JYW1;E7EQ D9;E9PDF6; Q9UBC5;O ;O43795 Cleavage stimulation factor subunit 2 tau variant SAM and SH3 domaincontaining protein 1 40S ribosomal protein S6 Unconventional myosin- Ia;Unconvention al myosin-ib CSTF2T 2.66E SASH1 2.69E RPS6 7.36E MYO1B;MYO1 A 3.88E LGASVIGID PVDENIKTA QCHK CQVSASEL HTSGILGPE TLR Q5T063;Q9 NZJ6 Hexaprenyldihyd roxybenzoate methyltransferas e, COQ3 2.56E A0A075B730;A0A087X1U6 EPPK1 1.81E S308

309 MLPDKDCR Oxidation (M); G3V1A4;E9 PP50;E9PK 25;P23528; E9PLJ3;E9P S23;E9PQB 7 Cofilin-1 CFL1 2.46E SPAESAAA GLTCLPSVT R DKEEIVICD R VDASACGM ER LLALTSSDL GCQPSRT QDEKECLK ESQVELRE QIDNLATEL CR CDSADLRH DIDR Q587I9 Q9NRR5-2;Q9NRR5 O ;O95671;O Q8IY95-2;Q8IY95 P23771;P O95295 E9PK09;E9 PQN2;E9PK I6;E9PK91; Q9NYF8-4;Q9NYF8-3;Q9NYF8-2;Q9NYF8 Vesicle transport protein SFT2C SFT2D3 2.01E Ubiquilin-4 UBQLN4 1.19E N- acetylserotonin O- methyltransferas e-like protein Transmembrane protein 192 Trans-acting T- cell-specific transcription factor GATA-3 SNAREassociated protein Snapin Bcl-2-associated transcription factor 1 ASMTL 4.69E TMEM E GATA3 7.00E SNAPIN 2.58E BCLAF1 5.44E RLEGIENDT QPILLQSCT GLVTHR O ;O ;O ;O95425 Supervillin SVIL 2.61E VLESHFQS QKDCYEKEI EALNFK VPDCFQR Q9NQX4 E7EMW7;O ;O95071 Unconventional myosin-vc E3 ubiquitinprotein ligase UBR5 MYO5C 3.33E UBR5 4.01E VIGSGCNLD SAR A0A087WU M2;P ;P ;P ;Q6ZMR3; P00338;P ;F5H5G7;F 5H155;A8M W50;G3XAP 5;F5H245;P 07864;P L-lactate dehydrogenase A chain;l-lactate dehydrogenase A-like 6A;Llactate dehydrogenase; L-lactate dehydrogenase C chain;l-lactate dehydrogenase B chain LDHA;LDHAL 6A;LDHC;LDH B 6.45E KCSTPEEIK P ;P60981;F6 RFD5 Destrin DSTN 6.20E SKGCGVVK FESPEVAE R VLMSVQYF LEDVDCK Oxidation (M); A0A087X0X 3;P ;P52272 C9K0E3;Q0 5655;Q Heterogeneous nuclear ribonucleoprotei n M Protein kinase C delta type;protein kinase C delta type regulatory subunit;protein HNRNPM 5.11E PRKCD 1.50E S309

310 kinase C delta type catalytic subunit FICEQDHQ NFLR Q ;Q ;Q92598;A 0A0A0MSM 0;Q Heat shock protein 105 kda HSPH1 4.15E IGLSVSEVIE GYEIACRK P ;P50990;P ;H7C4C8 T-complex protein 1 subunit theta CCT8 2.24E SLALEWAC SGIR AINCATSGV VGLVNCLR R KDLLVENVP YCDAPTQK Q KSYESSED CSEAAGSP ARK Carbamidomet hyl (C);IAAyne Q9BY49-2;Q9BY49 P49327 D6R994;Q5 U5X0 K7ER58;Q6 P6C2-3;Q6P6C2 Peroxisomal trans-2-enoyl- CoA reductase Fatty acid synthase;[acylcarrier-protein] S- acetyltransferas e;[acyl-carrierprotein] S- malonyltransfera se;3-oxoacyl- [acyl-carrierprotein] synthase;3- oxoacyl-[acylcarrier-protein] reductase;3- hydroxyacyl- [acyl-carrierprotein] dehydratase;en oyl-[acyl-carrierprotein] reductase;oleoyl -[acyl-carrierprotein] hydrolase Complex III assembly factor LYRM7 RNA demethylase ALKBH5 PECR 1.03E FASN 2.23E LYRM7 9.26E ALKBH5 1.90E LIDFLECGK TNLRR J3KTA4;P ;P17844;J3 QSF1;J3KR Z1 Probable ATPdependent RNA helicase DDX5 DDX5 1.22E LRLTVVDTP GYGDAINC R C9IY94;C9I ZU3;C9JQJ 4;C9J938;H 7C310;C9JB 25;C9J2Q4; B5MCX3;Q1 5019;Q ;Q ;B5MD47 Septin-2 SEPT2 1.76E AFDTAGNG YCR P49327 Fatty acid synthase;[acylcarrier-protein] S- acetyltransferas e;[acyl-carrierprotein] S- malonyltransfera FASN 5.21E S310

311 EACSYTIHA EGDER H0YGC7;F5 H362;F5H75 5;F5H5A1;Q 4G176 se;3-oxoacyl- [acyl-carrierprotein] synthase;3- oxoacyl-[acylcarrier-protein] reductase;3- hydroxyacyl- [acyl-carrierprotein] dehydratase;en oyl-[acyl-carrierprotein] reductase;oleoyl -[acyl-carrierprotein] hydrolase Acyl-CoA synthetase family member 3, ACSF3 1.07E LQEVECEE QR H0YK42;Q ;Q13596;Q Sorting nexin-1 SNX1 5.70E QCVPFRR A0A087WX M6;J3QQT2; J3KRX5;P18 621;P ;A0A087W Y81;J3KRB3 ;A0A087WW H0;J3QS96; J3QLC8;A0 A0A0MRF8; P S ribosomal protein L17 RPL E AKFENLCK FFSDCK RPPEACEE LR P08238;Q58 FF8 E9Y7;G8 JLB6;P3194 3;D6RIT2;D 6RF17;D6R DL0;E7EQJ 0;D6RAM1; D6R9T0;D6 RFM3;E7EN 40;D6RIU0; D6RDU3;D6 RJ04;D6RIH 9;D6RBM0; P55795 Heat shock protein HSP 90- beta;putative heat shock protein HSP 90- beta 2 Heterogeneous nuclear ribonucleoprotei n H;Heterogeneou s nuclear ribonucleoprotei n H, N-terminally processed;heter ogeneous nuclear ribonucleoprotei n H2;Heterogeneo us nuclear ribonucleoprotei n H2, N- terminally processed HEAT repeatcontaining protein 2 Q86Y56-2;Q86Y56 HSP90AB1;H SP90AB2P HNRNPH1;HN RNPH2 1.54E E HEATR2 4.81E S311

312 YIETSELCG GAR G8JLD5;O ;O ;O ;O ;O ;O00429;O ;O Dynamin-1-like protein DNM1L 1.31E LALEQQQLI CK LQISHEAAA CITGLR TIQFVDWC PTGFK MVSTPIGGL SYVQGCTK J3QK89;Q8I WX8 Q ;Q08211 F5H5D3;Q9 BQE3 D6RF87;E9 PF16;Q96C M8-3;Q96CM8; Q96CM8-2 Calcium homeostasis endoplasmic reticulum protein ATP-dependent RNA helicase A Tubulin alpha- 1C chain Acyl-CoA synthetase family member 2, CHERP 5.00E DHX9 8.43E TUBA1C 3.87E ACSF2 6.24E LECLQR Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E 9PMV1 Plectin PLEC 4.59E LLDAQLATG GLVCPARR A0A075B73 0;A0A087X1 U6;P58107 Epiplakin EPPK1 5.37E YIELFLNSC PK H0Y8R1;F5 H5I6;H0YAK 1;Q ;Q12849 G-rich sequence factor 1 GRSF1 4.51E EITEACVGS CEAK Carbamidomet hyl (C);IAAyne C9JFL8;C9J TY6;J3KR72 ;P ;P49848;P Transcription initiation factor TFIID subunit 6 TAF6 3.68E FASGGCDN LIK A8MXL6;P ;P55735;P Protein SEC13 homolog SEC E ADVIQATGD AICIFR E9PPZ7;E9 PMD4;Q FACT complex subunit SSRP1 SSRP1 2.47E CVEDPETG LR Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149 Plectin PLEC 5.61E SIEIPRPVD GVEVPGCG K K7ENG2;P ;P26368 Splicing factor U2AF 65 kda subunit U2AF2 1.98E S312

313 VVNEINIED LCLTK NTPSFLIAC NKQDIAMA K IHEGCEEPA THNALAK D6RCF4;Q8 N5K1 Q9Y5M8;H7 C4H2 A0A087WV Q6;Q ;Q00610 CDGSH ironsulfur domaincontaining protein 2 Signal recognition particle receptor subunit beta Clathrin heavy chain 1 CISD2 1.57E SRPRB 1.56E CLTC 7.01E FKTEQENE AKCR CKDFRER H0YNN5;P ;P83111 F8VW30;F8 VSL1;F8VZI 0;F8VX13;F 8VNX2;F8V ZQ1;P ;P08237;P Serine betalactamase-like protein LACTB, ATP-dependent 6- phosphofructoki nase, muscle type LACTB 7.36E PFKM 4.62E LTVVDTPG YGDAINCR C9IY94;C9I ZU3;C9JQJ 4;C9J938;H 7C310;C9JB 25;C9J2Q4; B5MCX3;Q1 5019;Q ;Q ;B5MD47 Septin-2 SEPT2 2.27E KLLAPDCEII QEVGK EACGVIVEL IK VTYTEFCQ GR GLESTTLAD KDGEIYCK Q9NQT5 Q9Y265-2;Q9Y265 Q86W50 P21291;E9P ND2;E9PP2 1 Exosome complex component RRP40 EXOSC3 6.91E RuvB-like 1 RUVBL1 4.40E Methyltransferas e-like protein 16 Cysteine and glycine-rich protein 1 METTL E CSRP1 8.56E TSNKPLMII HHLDECPH SQALKK Oxidation (M); C9J3E2;B5 MC07;O Anterior gradient protein 2 homolog AGR2 1.71E ETCSTLAES PR CAQYWPQK EEK FAEVECLAE SHQHLSK Q6P2E9-2;Q6P2E9 P18031;B4D SN5 F5GWX5;Q1 4839;Q Enhancer of mrnadecapping protein 4 Tyrosine-protein phosphatase non-receptor type 1;Tyrosineprotein phosphatase non-receptor type Chromodomainhelicase-DNAbinding protein 4 EDC4 3.80E PTPN1 3.49E CHD4 1.35E S313

314 LIEVANLAC SISNNEEGV K G3XAM7;P3 5221;P ;E5RFG3;E 5RFK9;E5R FM5;E5RJP 7;E5RGD2; P Catenin alpha-1 CTNNA1 4.58E NICFTVWD VGGQDR C9JPM4;C9 JAK5;P ADP-ribosylation factor 4 ARF4 3.04E SAEVCKQD SPFSR I3L2A2;I3L2 N7;Q ;Q92667 A-kinase anchor protein 1, AKAP1 3.20E SVGGACVL VA E9PJD9;P46 776;E9PLX7 60S ribosomal protein L27a RPL27A 1.93E TIESIQLSPE EYECLKGK O ;O ;O15091 Mitochondrial ribonuclease P protein 3 KIAA E EETQEDKD CPIKEEK ASGKESSG LVLLSSCPQ TASR SDCKEFSS EAR P18031;B4D SN5 C9JM75;H7 C454;H7C1 H7;Q6P087-2;Q6P087 I3L2D5;I3L2 39;I3L0K7;Q ;Q12931 Tyrosine-protein phosphatase non-receptor type 1;Tyrosineprotein phosphatase non-receptor type RNA pseudouridylate synthase domaincontaining protein 3 Heat shock protein 75 kda, PTPN1 2.40E RPUSD3 2.49E TRAP1 6.28E ELLNPVVEF VSHPSTTC R DAAFQNVL THVCLD VTDDLVCLV YK YYEKR ADLLLES HYR P ;P78527 Q8NBU5 P49458 P82921 M0QY43;Q7 Z406-5;Q7Z406-4;Q7Z406;Q 7Z406-6;Q7Z406-2 DNA-dependent protein kinase catalytic subunit PRKDC 2.81E ATPase family ATAD1 1.29E AAA domaincontaining protein 1 Signal SRP9 1.56E recognition particle 9 kda protein 28S ribosomal MRPS E protein S21, Myosin-14 MYH E ALIVVAE GKIPEESK AIELNPANA VYFCNR Q8WXA9-2 K7EMD6;O Splicing regulatory glutamine/lysinerich protein 1 Small glutaminerich tetratricopeptide repeatcontaining protein alpha SREK1 5.93E SGTA 2.66E S314

315 NQCLFTNT QCK Carbamidomet hyl (C);IAAyne B7Z6B6;B7Z 6Q2;D6RJ0 7;Q9UL40-3;Q9UL40;Q 9UL40-2 Zinc finger protein 346 ZNF E GTEAGQVG EPGIPTGEA GPSCSSAS DKLPR AGLENSLA ETECR O15355 C9JTG5;A8 MT21;CON P19012;P ;P19012 Protein phosphatase 1G Keratin, type I cytoskeletal 15 PPM1G 3.30E KRT E IIANALSSEP ACLAEIEED KAR LSIPTYGLQ CTR CGSSEDLH DSVR GEVTVT SASPLEEAT LSELK VCIESEHSM DTLLATLKK P ;P78527 P49327;J3K TF0 Q7Z4V5;Q7 Z4V5-3 H7C068;P E5RGN3;E5 RIM7;O DNA-dependent protein kinase catalytic subunit Fatty acid synthase;[acylcarrier-protein] S- acetyltransferas e;[acyl-carrierprotein] S- malonyltransfera se;3-oxoacyl- [acyl-carrierprotein] synthase;3- oxoacyl-[acylcarrier-protein] reductase;3- hydroxyacyl- [acyl-carrierprotein] dehydratase;en oyl-[acyl-carrierprotein] reductase;oleoyl -[acyl-carrierprotein] hydrolase Hepatomaderived growth factor-related protein 2 ATP synthase subunit O, Copper transport protein ATOX1 PRKDC 1.11E FASN 1.94E HDGFRP2 1.39E ATP5O 1.08E ATOX1 2.56E EFPVISVVG YTNCGK LFQECCPH STDR Carbamidomet hyl (C);IAAyne H0Y2S1;O Q5T6W1;P6 1978;P ;Q5T6W2; Q5T6W5;P Putative GTPbinding protein 6 Heterogeneous nuclear ribonucleoprotei n K GTPBP6 2.92E HNRNPK 1.73E VRFACHSA SLTVR VQENSAYIC SR ELVLDNCK C9IZL7;C9J YS8;Q ;Q15233 Q9Y3T9 Q ;Q92688 Non-POU domaincontaining octamer-binding protein Nucleolar complex protein 2 homolog Acidic leucinerich nuclear phosphoprotein NONO 3.78E NOC2L 3.61E ANP32B 1.03E S315

316 32 family member B NLETFCEET RR YLAEVACG DDR SREPQAKP QLDLSIDSL DLSCEEGT PLSITSK Q9P2J5-2;Q9P2J5 P27348;E9P G15 A0A087WY6 1;Q ;Q14980;Q Leucine--tRNA ligase, cytoplasmic protein theta Nuclear mitotic apparatus protein 1 LARS 3.00E YWHAQ 1.86E NUMA1 1.83E SVAPAAPT SCDFSPGD LVWAK F8WAX8;A0 A087WWJ1; P ;P52701 DNA mismatch repair protein Msh6 MSH6 2.24E ISDLEICAD EFPGSSAT YR A0A087WW 35;Q96IZ6-2;Q6P1Q9-2;Q96IZ6;Q 6P1Q9 Methyltransferas e-like protein 2A;Methyltransfe rase-like protein 2B METTL2A;ME TTL2B 1.62E LVSVNEYCL DNTSLAEA VEILK A0A087WU Z6;Q8NI35-5;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35 InaD-like protein INADL 1.63E MYGISLCQ AILDETKGD YEK LISDAGYQG EITSVSTAC QQLEVFSR YVLCTAPR GASCPDFR P04083 Annexin A1 ANXA1 1.51E X6RLT1;H0 UI80;Q8IXH 7-4;Q8IXH7 J3KQ69;P25 205;P K7EQL1;K7 EQT7;Q17R N3-2;Q17RN3 Negative elongation factor C/D DNA replication licensing factor MCM3 NELFCD;TH1 L 1.67E MCM3 4.36E Protein FAM98C FAM98C 1.63E GEELSCEE R GEELSCEE RNLLSVAYK CEFQDAYV LLSEKK HATAEEVE EEERDRIPG PVCK VGVDYEGG GCR IIYEQEGVYI HSSCGK P31947;P P31947;P P10809 Q8TDN6 Q02809;Q Q8TC07-2;Q8TC07;F 8WDJ1;F8W F35;F8WCB protein sigma protein sigma 60 kda heat shock protein, Ribosome biogenesis protein BRX1 homolog Procollagen- lysine,2- oxoglutarate 5- dioxygenase 1 TBC1 domain family member 15 SFN 4.33E SFN 7.03E HSPD1 6.47E BRIX1 5.70E PLOD1 4.36E TBC1D E VAYQDPSS GCTSK E9PNR2;Q ;Q13671 Ras and Rab interactor 1 RIN1 9.47E S316

317 IGLSVSEVIE GYEIACR P ;P50990;P ;H7C4C8 T-complex protein 1 subunit theta CCT8 1.88E ALLYLCGG DD CMALSTAV LVGEAKK EIADGLCLE VEGK Oxidation (M); P07355;A6N MY6;P G3V4Z4;Q ;Q02252 J3KPG2;E9 PJF7;Q5W0 H4;P13693 Annexin A2;Putative annexin A2-like protein Methylmalonatesemialdehyde dehydrogenase [acylating], Translationallycontrolled tumor protein ANXA2;ANXA 2P2 1.54E ALDH6A1 2.35E TPT1 1.37E SIQFVDWC PTGFK P ;P ;P68366;P Tubulin alpha- 1B chain;tubulin alpha-4a chain TUBA1B;TUB A4A 7.87E IVEDDASIS SCNK Q7Z5K2;Q7 Z5K2-2;Q7Z5K2-3 Wings apart-like protein homolog WAPAL 9.27E IFVGNVSAA CTSQELR F8WDX3;A0 A0A0MSL8; B8ZZ74;Q96 PK6-3;Q96PK6-4;Q96PK6-2;Q96PK6-5;Q96PK6 RNA-binding protein 14 RBM E ITNQVIYLN PPIEECR IMKDLDQC R SEETNTEIV ECILKR SEKPPAGSI CR MVSTPIGGL SYVQGCTK K Q14204 Cytoplasmic dynein 1 heavy chain 1 P60903 Protein S100- A0A087WV6 6;P46013;P P56182 D6RF87;E9 PF16;Q96C M8-3;Q96CM8; Q96CM8-2 DYNC1H1 7.85E S100A E A10 Antigen KI-67 MKI E Ribosomal RNA processing protein 1 homolog A Acyl-CoA synthetase family member 2, RRP1 6.31E ACSF2 8.37E ELCHTQSS HASLR F8W7S5;A0 A087WVV2; A0A0A0MR V0;Q9P2E9-3;Q9P2E9-2;Q9P2E9 Ribosomebinding protein 1 RRBP1 2.75E STSTSEPTT GCSLK VVVPIYCTS FLAVEEDK QQK EGCTVSPE TISLNVK Q8ND82 J3QK89;Q8I WX8 E5KLK1;E5 KLJ6;E5KLJ 9;E5KLJ5;O 60313;O Zinc finger protein 280C Calcium homeostasis endoplasmic reticulum protein Dynamin-like 120 kda protein, ;Dy namin-like 120 kda protein, form S1 ZNF280C 1.22E CHERP 3.20E OPA1 2.66E S317

318 GYLGPEQL PDCLKGCD VVVIPAGVP R VCNYGLTF TQK Carbamidomet hyl (C);IAAyne P ;P40926 Q9Y277;E5 RHE1;E5RJ N6;E5RHZ6; Q9Y277-2;E5RK27;E 5RFP6 Malate dehydrogenase, Voltagedependent anion-selective channel protein 3 MDH2 2.99E VDAC3 6.00E CESAFLSK R C9JXB8;C9J NW5;P S ribosomal protein L24 RPL E QAAVLF FDELDSIAK DLNCVPEIA DTLGAVAK LASTPFKG GTLFGGEV CK SIKDTICNQ DER P55072 G3V507;G3 V2F5;G3V5 80;G3V2L6; G3V2X6;C9 JSX3;O ;O14744 P42166 H0YHL7;B4 E3S0;Q9UL V4;Q9ULV4-2;Q9ULV4-3 Transitional endoplasmic reticulum ATPase Protein arginine N- methyltransferas e 5;Protein arginine N- methyltransferas e 5, N-terminally processed Laminaassociated polypeptide 2, isoform alpha;thymopoi etin;thymopenti n Coronin;Coronin -1C VCP 1.97E PRMT5 8.33E TMPO 6.85E CORO1C 9.72E GLGDCLVK GFNKETAA ACVEK SLESCLLDL R LVMSYVAA VCGK Oxidation (M); P05141;P E9PGT1;Q Q6ZRV2;J3 KPS2 C9JUP5;C9 JYW1;E7EQ D9;E9PDF6; Q9UBC5;O ;O43795 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;adp/ ATP translocase 3;ADP/ATP translocase 3, N-terminally processed SLC25A5;SLC 25A6 5.45E Translin TSN 1.94E Protein FAM83H FAM83H 4.24E Unconventional myosin- Ia;Unconvention al myosin-ib MYO1B;MYO1 A 3.88E S318

319 LLLEHLECL VSR R4GNF1;F8 VWR9;E9PP F6;E9PJZ7; R4GN36;B1 APN9;G3V2 00;O ;O ;Q ;O75335;O ;O75145;Q 13136;O ;O ;O ;O75334 Liprin-alpha- 2;Liprin-alpha- 1;Liprin-alpha- 4;Liprin-alpha-3 PPFIA3;PPFIA 2;PPFIA1;PPF IA4 1.50E LLGPTVML GGCEFSR LVSSCIV TSTYGWTA NMER CIPYAVLLE ALALR Oxidation (M); Carbamidomet hyl (C);IAAyne Q8N9T8 P08238 F5H4U8;F5 H7C6;F5GY F7;F5H248; Q9UBW8 Protein KRI1 homolog Heat shock protein HSP 90- beta COP9 signalosome complex subunit 7a KRI1 2.47E HSP90AB1 5.70E COPS7A 3.33E YSYVCPDL VK FENLCK EKQEEEEA KCLEK P61158;B4D XW1 P08238;Q58 FF8;Q58FG 0;Q58FF7;P 07900;P Heat shock protein HSP 90- beta;putative heat shock protein HSP 90- beta 2;Putative heat shock protein HSP 90- alpha A5;Putative heat shock protein HSP 90-beta- 3;Heat shock protein HSP 90- alpha E3 ubiquitinprotein ligase HUWE1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Actin-related protein 3 ACTR3 1.36E HSP90AB1;H SP90AB2P;H SP90AA5P;H SP90AB3P;H SP90AA1 1.47E HUWE1 3.34E EAVQLVNT REEVEDLC R DLNYCFSG MSDHR Oxidation (M); P ;P54886 E9Y7;G8 JLB6;P3194 3;H0YBG7; H0YBD7;H0 YB39;P Delta-1- pyrroline-5- carboxylate synthase;glutam ate 5- kinase;gammaglutamyl phosphate reductase Heterogeneous nuclear ribonucleoprotei n H;Heterogeneou s nuclear ribonucleoprotei n H, N-terminally processed;heter ogeneous nuclear ribonucleoprotei n H2;Heterogeneo ALDH18A1 1.15E HNRNPH1;HN RNPH2 3.16E S319

320 us nuclear ribonucleoprotei n H2, N- terminally processed NLLQLCPQ SLEALAVR CLQWTTVIE R E9PS82;B4 DXN4;Q969 H4-2;Q969H4 M0R0P9;P ;Q9Y243-2;Q9Y243;P 31749;P317 51;J3KTP4; G3V4I6;C9J 258;J3KSY8 ;G3V3K5;C9 JC83;C9JIJ1 ;A0A0A0MR F1;J3KRI8;A 8MX96;E7E VP8;F8VS9 1;M0QZK3;J 3QLS6;C9J HS6;P Connector enhancer of kinase suppressor of ras 1 RAC-alpha serine/threonineprotein kinase;racgamma serine/threonineprotein kinase;racbeta serine/threonineprotein kinase CNKSR1 6.56E AKT2;AKT1;A KT3 1.48E YLAEVACG DDRK AALETDENL LLCAPTGA GK CAAQTLEK AIVPPYSLC QTGEDLPK DK P27348;E9P G15 O75643;O E9PQ61;O U5 small nuclear ribonucleoprotei n 200 kda helicase Zinc finger CCCH domaincontaining protein 11A OTU domaincontaining protein 4 Q ;Q ;Q protein theta YWHAQ 1.49E SNRNP E ZC3H11A 3.02E OTUD4 5.74E TIIGQQGDQ SCANK YEAAFPFLS GR P ;P35251 H0YF29;Q6 P1X6-2;Q6P1X6 Replication factor C subunit 1 UPF0598 protein C8orf82 RFC1 1.81E C8orf E AKPKAPPP SLTDCIGTV DSR APPPTPAP SGCDPR SANALILTY DITCEESFR Q9NZZ3-2;Q9NZZ3 O95685 H0YDK7;Q1 5771;E9PI1 8;E9PLM3;E 9PJQ5;E9P RF7;E9PNB 9;E9PS06;E 9PMJ1;Q Charged multivesicular body protein 5 Protein phosphatase 1 regulatory subunit 3D Ras-related protein Rab-30 CHMP5 1.19E PPP1R3D 2.81E RAB E MKLNISFPA TGCQK DLKPSNLLL NTTCDLK P62753;A2A 3R7 P ;P S ribosomal protein S6 Mitogenactivated protein kinase 1 RPS6 7.36E MAPK1 1.21E S320

321 VLLISGFPV QVCK IVSLPECFN SPYGAK Q5SZR4;F6 TB26;Q9Y2 W6;E9PKN8 H7C579;Q9 NQR4;F8W F70 Tudor and KH domaincontaining protein Omega-amidase NIT2 TDRKH 1.79E NIT2 2.31E IIQLLDDYPK CFIVGADNV GSK F8VQY6;F8 VRK7;G3V2 10;F8VU65; F8VWS0;P ;Q8NHW5; P05388;F8V S58;F8VZS0 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like RPLP0;RPLP0 P6 1.34E TSNKPLMII HHLDECPH SQALKK C9J3E2;B5 MC07;O Anterior gradient protein 2 homolog AGR2 1.71E VGSFCLSE AGAGSDSF ALK SLSSLELFL SCAQK P ;P45954 H0YH50;H0 YGN9;H0YF R6;H0YGB4 ;Q7Z6B0-3;Q7Z6B0-2;Q7Z6B0 Short/branched chain specific acyl-coa dehydrogenase, Coiled-coil domaincontaining protein 91 ACADSB 1.30E CCDC E ARFEELCS DLFR TTGLVGLAV CNTPHER CGSKDNIK HVPGGGNV QIQNK V9GZ37;P ;P08107;P 48741;P F8WAS3;Q E7EVA0;P ;P27816;H 0Y2V1;F8W 9U4;P ;P Heat shock 70 kda protein 1A/1B;Putative heat shock 70 kda protein 7;Heat shock 70 kda protein 6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Microtubuleassociated protein;microtub ule-associated protein 4 HSPA1A;HSP A7;HSPA6 2.09E NDUFA5 2.10E MAP4 1.24E VFPPEIVEQ MGCK I3L0N3;P ;P46459 Vesicle-fusing ATPase NSF 5.54E GAYRDCLG R Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q ;Q15149;E 9PMV1 Plectin PLEC 1.15E FILLACDGL FK H7C2I8;F8S NU7;Q9H0C 8 Integrin-linked kinaseassociated serine/threonine phosphatase 2C ILKAP;ILKAP3 3.49E S321

322 QIGIDPPRG VLMYGPPG CGK CGFLPGNE K Oxidation (M); P ;P43686 H0YKU2;H0 YM70;A0A0 87X1Z3;Q9 UL46 26S protease regulatory subunit 6B Proteasome activator complex subunit 2 PSMC4 7.91E PSME2 5.29E ILDILGETCK QRPGQQVA TCVR Q14151;Q ;Q15424;Q ;Q O ;O75534;O ;O ;E9PLT0 Scaffold attachment factor B2;Scaffold attachment factor B1 Cold shock domaincontaining protein E1 SAFB2;SAFB 1.58E CSDE1 5.68E CAAQTLEK R SKKPLMVIH HLEDCQYS QALK E9PQ61;O H7C040;B5 MC62;Q8TD 06 Zinc finger CCCH domaincontaining protein 11A Anterior gradient protein 3 homolog ZC3H11A 9.77E AGR3 2.76E IICSAGLSLL AEER LLVLEAFQV SHR S4R338;Q9 BV86 G3V3B9;A0 A0A0MR33; G3V267;G3 V5T0;G3V4 T6;O ;O ;O43708 N-terminal Xaa- Pro-Lys N- methyltransferas e 1;N-terminal Xaa-Pro-Lys N- methyltransferas e 1, N-terminally processed Maleylacetoacet ate isomerase NTMT1 8.52E GSTZ1 3.37E ATQCVPKE EIKDDNPHL K CMALSTAV LVGEAKK QAAECGPE PGVSGVGE LIVR VANVIVDHS LQDCVFSK Q9HAV7 G3V4Z4;Q ;Q02252 Q9HBH5 J3QLD1;J3K SU6;J3QKW 3;J3KSB8;J 3QRZ6;J3Q LJ5;A9UHW 6;A9UHW6-2;A9UHW6-3 GrpE protein homolog 1, Methylmalonatesemialdehyde dehydrogenase [acylating], Retinol dehydrogenase 14 MIF4G domaincontaining protein GRPEL1 5.74E ALDH6A1 2.35E RDH E MEOX1;MIF4 GD 2.75E IREIADGLC LEVEGK J3KPG2;E9 PJF7;Q5W0 H4;P13693 Translationallycontrolled tumor protein TPT1 3.54E TGVHHYSG NNIELGTAC GK E5RI99;P S ribosomal protein L30 RPL E S322

323 NCLALADD KKLK B4DJC3;O ;O ;O75367 Histone H2A;Core histone macro- H2A.1 H2AFY 1.73E DLNYCFSG MSDHR VGEATETAL TCLVEK E9Y7;G8 JLB6;P3194 3;H0YBG7; H0YBD7;H0 YB39;P H7C5W9;P ;P16615;P ;P ;Q ;Q ;P ;Q ;Q ;Q93084;Q ;Q Heterogeneous nuclear ribonucleoprotei n H;Heterogeneou s nuclear ribonucleoprotei n H, N-terminally processed;heter ogeneous nuclear ribonucleoprotei n H2;Heterogeneo us nuclear ribonucleoprotei n H2, N- terminally processed Sarcoplasmic/en doplasmic reticulum calcium ATPase 2;Sarcoplasmic/ endoplasmic reticulum calcium ATPase 3 HNRNPH1;HN RNPH2 ATP2A2;ATP2 A3 3.16E E EGITGPPAD SSKPIGPDD AIDALSSDF TCGSPTAA GKK E9PDE4;E7 ES10;E7EV Y3;B7Z574; P ;P ;P20810;P ;P ;P ;P ;H0YA91 Calpastatin CAST 2.11E APEYKD WLTK LPAEPPALL QTHPR P ;P78527 I3L2A2;I3L2 N7;Q ;Q92667;I3 L0K6 DNA-dependent protein kinase catalytic subunit A-kinase anchor protein 1, PRKDC 6.56E AKAP1 4.48E SAPHLPGL MCLLR I3L1P4;I3L4 M7;I3L445;C 9JFV4;Q8IZ L8 Proline-, glutamic acidand leucine-rich protein 1 PELP1 1.42E SAPHLPGL MCLLR Oxidation (M); I3L1P4;I3L4 M7;I3L445;C 9JFV4;Q8IZ L8 Proline-, glutamic acidand leucine-rich protein 1 PELP1 1.42E S323

324 YMACCLLY RGDVVPK Carbamidomet hyl (C);Oxidation (M); P ;P ;P68366;P 68363;A6NH L2-2;A6NHL2;F 5H5D3;Q9B QE3 Tubulin alpha- 1B chain;tubulin alpha-4a chain;tubulin alpha chain-like 3;Tubulin alpha- 1C chain TUBA1B;TUB A4A;TUBAL3; TUBA1C 8.51E NILGGTVFR EPIICK SIQTICSGLL TDVEDQAA K SIPLECPLS SPK P ;P48735 A0A087X23 9;Q6B5-2;Q6B5 I3L2A2;I3L2 N7;Q ;Q92667 Isocitrate dehydrogenase [NADP], Round spermatid basic protein 1-like protein A-kinase anchor protein 1, IDH2 2.60E RSBN1L 6.98E AKAP1 2.79E CLEEKNEIL QGK A0A087WY6 1;Q ;Q14980;Q ;Q ;Q ;F5H6Y5;F 5H4J1 Nuclear mitotic apparatus protein 1 NUMA1 1.78E CPQVVISFY EER EINDCIGGT VLNISK VAASCGAIQ YIPTELDQV RK CCLWCLEK Carbamidomet hyl (C);2 IAAyne J3KS05;P J3QSV6;O J3KNJ2;Q7L 2H7;E9PN8 6 Q53GD3-2;Q53GD3-3;Q53GD3-4;Q53GD3 Chromobox protein homolog 1 Ribosomal L1 domaincontaining protein 1 Eukaryotic translation initiation factor 3 subunit M Choline transporter-like protein 4 CBX1 1.54E RSL1D1 1.92E EIF3M 7.40E SLC44A4 6.84E MKVACITEQ VLTLVNKR DLSYCLSG MYDHR NLSTFAVD GKDCK Oxidation (M); B7Z4L4;P P52597 A0A096LP7 3;A0A096LP 12;A0A096L NH5;H7C2G 3;F2Z2Q0;H 7BYH1;A0A 096LPI6;P Dolichyldiphosphooligos accharide-- protein glycosyltransfera se subunit 1 Heterogeneous nuclear ribonucleoprotei n F;Heterogeneou s nuclear ribonucleoprotei n F, N-terminally processed ES1 protein homolog, RPN1 1.18E HNRNPF 7.05E C21orf E S324

325 CPENAFFL DHVR F5H6E2;O ;O ;O00159 Unconventional myosin-ic MYO1C 7.00E CAAVDVEP PSK NYLSCDVE VR CIESLIAVFQ K AIVLFTSDA CGLSDAAHI ESLQEK QGEYGLASI CNGGGGAS AMLIQK YVENPSQV LNCER F8VV04;Q ;Q15020 P43304;P Squamous cell carcinoma antigen recognized by T- cells 3 Glycerol-3- phosphate dehydrogenase, P31949 Protein S100- A11;Protein S100-A11, N- terminally processed F1DAL9;P P24752 E9PF10;O ;O75694 COUP transcription factor 1 Acetyl-CoA acetyltransferas e, Nuclear pore complex protein Nup155 SART3 4.76E GPD2 4.78E S100A E NR2F1 6.35E ACAT1 3.52E NUP E GVLFYGPP GCGK SISIPGQDS SLQLTCK P55072 Q5T9C2-3;Q5T9C2-2;Q5T9C2 Transitional endoplasmic reticulum ATPase Protein FAM102A VCP 9.15E FAM102A 5.80E CLELFTELA EDKENYKK P07900;P Heat shock protein HSP 90- alpha HSP90AA1 1.50E S325

326 X-ray crystallography data Crystal data and structure refinement for AA-CW231 (CCDC ) Empirical formula C 13H 15BrClN 3 Formula weight Temperature/K 184(8) Crystal system orthorhombic Space group P a/å (9) b/å (19) c/å (4) α/ 90 β/ 90 γ/ 90 Volume/Å (4) Z 4 ρ calcg/cm μ/mm F(000) Crystal size/mm Radiation CuKα (λ = ) 2Θ range for data collection/ to Index ranges -5 h 5, -12 k 13, -27 l 30 Reflections collected 8526 Independent reflections 2692 [R int = , R sigma = ] Data/restraints/parameters 2692/0/165 Goodness-of-fit on F Final R indexes [I>=2σ (I)] R 1 = , wr 2 = Final R indexes [all data] R 1 = , wr 2 = Largest diff. peak/hole / e Å /-0.42 Flack parameter 0.002(18) S326

327 Crystal data and structure refinement for AA-CW251 (CCDC ) Empirical formula C 15H 16ClN 3O 3 Formula weight Temperature/K (14) Crystal system monoclinic Space group I2/a a/å (19) b/å (19) c/å (6) α/ 90 β/ (19) γ/ 90 Volume/Å (10) Z 8 ρ calcg/cm μ/mm F(000) Crystal size/mm Radiation CuKα (λ = ) 2Θ range for data collection/ to Index ranges -11 h 11, -13 k 13, -36 l 36 Reflections collected Independent reflections 3075 [R int = , R sigma = ] Data/restraints/parameters 3075/0/200 Goodness-of-fit on F Final R indexes [I>=2σ (I)] R 1 = , wr 2 = Final R indexes [all data] R 1 = , wr 2 = Largest diff. peak/hole / e Å /-0.60 S327

328 Crystal data and structure refinement for AA-CW263 (CCDC ) Empirical formula C 18H 20ClN 3O 3 Formula weight Temperature/K (14) Crystal system monoclinic Space group P2 1/n a/å (8) b/å (2) c/å (10) α/ 90 β/ (6) γ/ 90 Volume/Å (16) Z 4 ρ calcg/cm μ/mm F(000) Crystal size/mm Radiation CuKα (λ = ) 2Θ range for data collection/ 8.71 to Index ranges -22 h 20, -6 k 6, -21 l 24 Reflections collected Independent reflections 3393 [R int = , R sigma = ] Data/restraints/parameters 3393/0/226 Goodness-of-fit on F Final R indexes [I>=2σ (I)] R 1 = , wr 2 = Final R indexes [all data] R 1 = , wr 2 = Largest diff. peak/hole / e Å /-0.60 S328

329 Crystal data and structure refinement for AA-CW239 (CCDC ) Empirical formula C 13H 19ClN 4O Formula weight Temperature/K (10) Crystal system triclinic Space group P-1 a/å (4) b/å (7) c/å (8) α/ (6) β/ (6) γ/ (5) Volume/Å (9) Z 2 ρ calcg/cm μ/mm F(000) Crystal size/mm Radiation CuKα (λ = ) 2Θ range for data collection/ to Index ranges -5 h 8, -13 k 12, -14 l 13 Reflections collected 4377 Independent reflections 2764 [R int = , R sigma = ] Data/restraints/parameters 2764/0/175 Goodness-of-fit on F Final R indexes [I>=2σ (I)] R 1 = , wr 2 = Final R indexes [all data] R 1 = , wr 2 = Largest diff. peak/hole / e Å /-0.39 S329

330 Crystal data and structure refinement for AA-CW236 (CCDC ) Empirical formula C 17H 16ClF 3N 4O 2 Formula weight Temperature/K 184(9) Crystal system triclinic Space group P-1 a/å (7) b/å (7) c/å (7) α/ (5) β/ (6) γ/ (6) Volume/Å (11) Z 2 ρ calcg/cm μ/mm F(000) Crystal size/mm Radiation CuKα (λ = ) 2Θ range for data collection/ to Index ranges -10 h 10, -12 k 12, -8 l 13 Reflections collected 6730 Independent reflections 3486 [R int = , R sigma = ] Data/restraints/parameters 3486/77/292 Goodness-of-fit on F Final R indexes [I>=2σ (I)] R 1 = , wr 2 = Final R indexes [all data] R 1 = , wr 2 = Largest diff. peak/hole / e Å /-0.39 S330

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397 References [1] ) L. N. Gosw m, Z. H. Ho sto, S. J. S rm, S. S. J s t, M. F. H wthor, Org Biomol Chem 2013, 11, ; ) M. D. P. R ss w, D. J. H. D C rcq, S. L v s, U. H rt, D. S v, F. V d Bro ck, J. C. M rt s, J. T v r r, S. V C r h, ChemMedChem 2013, 8, [2] ) F. K ck, F. D. Tost, J Am Chem Soc 2009, 131, ; ) A. D. Worth, C. L. Jo, T. E. L ht r, K. L. T, J Am Chem Soc 2010, 132, ; c) E. G. Cork m, M. J. H ss, A. D. S v, S. H. B r s, Org Lett 2011, 13, [3] ) L. S. B ch r, N. D. P. Cosford, A. H r t, J. S. McC m, I. A. McDo d, J Org Chem 1998, 63, ; ) M. F rst, H. Do c t, M. S t, Tetrahedron Lett 2005, 46, [4] ) L. Zh, X. G. Ch, P. X, H. H. Y. S, I. D. W ms, K. B. Sh rp ss, V. V. Fok, G. C. J, J Am Chem Soc 2005, 127, ; ) M. M. M j r ck, S. M. W r, J Org Chem 2006, 71, ; c) B. C. Bor, S. N r, L. K. R sm ss, L. Zh, H. T. Zh o, Z. Y. L, G. C. J, V. V. Fok, J Am Chem Soc 2008, 130, [5] W. E. Co r d, K. X. Rodr, H. H. N, J. C. F tt r, M. J. H dd d, M. J. K rth, Org Lett 2012, 14, [ ] F. S r, K. K m o, M. Em r, U. Mohr, J. Thom, Mutation Research 1997, 385, [7] P. J. Bo rs m, R. R jm k rs, S. L m r, S. Moh mm d, A. J. H ck, Nature Protocols 2009, 4, [8] J. Cox, M. M, Nat Biotechnol 2008, 26, [9] J. K. E, A. L. Mccorm ck, J. R. Y t s, J Am Soc Mass Spectr 1994, 5, S397