Study Guide. Research Master Programmes in Health Sciences and Clinical Research for medical students
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1 NIHES RESEARCH TRAINING IN MEDICINE AND THE HEALTH SCIENCES Study Guide Research Master Programmes in Health Sciences and Clinical Research for medical students
2 Adjustments Page 14: correction amount of ECTS of EP03/electives and correction total amount of courses and research Page 15: correction amount of ECTS of EP03/electives and correction total amount of courses and research Page 17: 1 st EWP is in first year Research Master Health Sciences and Clinical Research (instead of the continued year 1 of Research Master), orientation research area is in January of year 2 instead of February year 1, second EWP is in the continued year 1 of Research Master (instead of year 2), correction amount of ECTS of EP03/electives and correction total amount of courses and research. Page 20: adjustment, because schedule is also for option 2 students who started in 2012 (until EWP), correction exam date of EWP04 and EWP16. Page 22: correction exam date of EWP03 and EWP13, correction of the number of ECTS and amount of days for the advanced electives. Page 26: correction exam date of EWP04 and EWP16. Page 28: correction exam date of EWP03 and EWP13, correction of the number of ECTS and amount of days for the advanced electives.
3 Erasmus MC and Netherlands Institute for Health Sciences Study Guide Research Master programmes Health Sciences and Clinical Research for Medical Students
4 2012 Erasmus MC and the Netherlands Institute for Health Sciences, Rotterdam All rights reserved. No part of this study guide may be reproduced, stored in a database or retrieval system, or published, in any form or in any way, electronically, mechanically, by print, photo print, microfilm or any other means without prior written permission from the publisher. Every effort has been made to ensure that the information contained in this study guide is accurate at the time of publication. However, the staff of the master programmes Health Sciences and Clinical Research reserve the right to make changes without prior notice. Erasmus MC and Netherlands Institute for Health Sciences 2
5 Health Sciences & Clinical Research for Medical Students Word of welcome Dear student, In the medical sciences, new knowledge and skills are needed at an ever-increasing level of speed in the medical sciences. Many researchers all over the world contribute to this process. In the center of these new developments stands the doctor, who is able to ask the right questions about patient-related problems and translate them into a research protocol. Such protocols may concern laboratory research and/or applied clinical research. Medical sciences need doctors, with the ability and ambition to combine patient care and research in an academic framework. Erasmus MC is the only university medical center in the Netherlands offering five officially accredited Research Master programmes. These programmes provide the students with the challenge and opportunity to become medical researchers, contributing to the advancement of medical science. Qualified students, who seek the challenge of scientific research, may choose from the five Research Master programmes: Health Sciences, Clinical Research, Infection & Immunity, Molecular Medicine or Neuroscience. This study guide contains all necessary information for students with the ambition to be trained in the field of medical and health sciences and become a Master of Science in Clinical Research or Health Sciences. The programmes include an educational part and a research part. Outstanding researchers with an international reputation will conduct both parts. Take the challenge and provide yourself with the opportunity of a varied and exciting professional career. Good luck! Professor Albert Hofman, MD PhD Programme Director Health Sciences Professor Aart Jan van der Lely, MD PhD Programme Director Clinical Research 3 Study Guide
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7 Health Sciences & Clinical Research for Medical Students Table of Content Word of welcome... 3 Table of Content Aim of the programme Preliminary programme and general information Introduction Schedule & combination of the programme in the medical curriculum at Erasmus MC Recommended books Availability of standard computer software... 8 Time table Preliminary Programme Research Masters Health Sciences and Clinical Research Research Master Programmes option 1 and Schedule & combination of the programme with the regular medical curriculum Programme information Course exemptions from courses of your Research Master programme Course exemptions from courses of your Master of Science in Medicine Course evaluations Cancelling your participation in a course Confidential counsellor...12 Table 1 - start 2012 option Table 2 - start 2011 option Table 3 option Research project & time table Research Master Health Sciences Research project...18 Practical research Your research proposal Presenting your research Your thesis Time table Research Master Health Sciences for Master students in Medicine, option Start 2012 First year Start 2011 Second year Research project & time table Research Master Clinical Research Research project...23 Practical research Your research proposal Presenting your research Your thesis Time table Research Master in Clinical Research Time table Research Master Clinical Research for Master students in Medicine option Start 2012 First year Time table Research Master Clinical Researhc for Master students in Medicine option Start 2011 Second year Examination Procedure and Rules TER and Examination Board Attainment targets Students overall rights and duties Graduation Graduation ceremony NIHES Award and Erasmus MC MSc CR Award After graduation Stay in touch!...33 Annex I NIHES Administration NIHES office hours NIHES intranet Staff Health Sciences & Clinical Research...34 Annex II: Course descriptions NIHES courses... Error! Bookmark not defined. 5 Study Guide
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9 Health Sciences & Clinical Research for Medical Students 1. Aim of the programme The Research Master programmes in Health Sciences and in Clinical Research aim to provide students with a thorough understanding of methods in clinical research and sufficient knowledge of clinical specialist areas, for example medical technology, immunology or molecular biology. On the basis of this knowledge, the student will be prepared to write a research protocol and to perform research. Students should acquire the following competencies: Ability to formulate a clinical problem and translate it into a scientific question. Ability to perform an extensive study of the literature concerning a clinical problem. Ability to translate a scientific question into a research protocol. Acquisition of sufficient knowledge of existing methods of clinical scientific research, biostatistical analytical methods, laws, regulations and ethics and the abilities to use such knowledge in a research protocol. Ability to conduct the research, collect and analyse data, and draw conclusions. Ability to write a Master s thesis, including the objective(s) of the investigation, a summary of the literature, materials, methods, results, discussion and conclusions of the research project and to present these findings at scientific meetings. Publication of the research findings in an international peer-reviewed journal is encouraged. This skills set will enable students to become researchers with the ability to complete a PhD programme, preferably as part of their specialist-education (so-called AGIKO-construction). The ultimate goal of the Research Master in Health Sciences or Clinical Research is to scout excellent students at an early age, challenge them to become clinical investigators, foster them during their research- and clinical career and motivate them to become academic specialists and possibly future professors of medicine. 7 Study Guide
10 2. Preliminary programme and general information 2.1 Introduction In this chapter the general outline of the Preliminary programme will be described. The Preliminary programme is an introduction to the Research Masters Health Sciences and Clinical Research for medical students who attend the Bachelor and Master programmes in Medicine. In chapter 3, the general outline of the Research Master programmes for the BaMa curriculum is described. For more details on the schedules of the BaMa curricula see chapter 4 (Health Sciences) and 5 (Clinical Research). The doctoraal students in Medicine who attend Research Masters Health Sciences or Clinical Research and started in August 2009 the latest, follow the doctoraal curriculum. The general outline of these doctoraal curricula, the Research Master in Health Sciences and the Research Master in Clinical Research is available in the Study Guide or earlier. 2.2 Schedule & combination of the programme in the medical curriculum at Erasmus MC Second year bachelor students in medicine, who are interested in doing research, can attend the keuzeonderwijs Ever thought of doing research? (KOW2), an elective programme in the second year of the Bachelor s programme in Medicine. You can apply for the Preliminary programme of the Research Masters Health Sciences and Clinical Research when you want to attend the Research Master Health Sciences or Clinical Research. When you are admitted to this Preliminary programme, you will start the programme in the third year of your medical bachelor (see the schedule on page 10) You participate in the Erasmus Summer Programme (three weeks), which is held in August. After the Erasmus Summer Programme, you continue with the minor Ever thought of doing research?. This 10 weeks programme is organized by several Erasmus MC Research Master programmes. From November to the following August you get acquainted with your research area and attend research seminars. Research Seminars run parallel to the medical curriculum. Preliminary students Health Sciences receive a seminar booklet in which they can register their seminars with the original signature of the lecturer. Preliminary students Clinical Research can register their seminars in their Personal Education Programme (PEP) (see chapter 5 for details). At the end of your third year Bachelor in Medicine the selection committee will decide whether you can start with the research master. 2.3 Recommended books With a few exceptions, all course materials are included in the NIHES tuition fee. Below are the exceptions, which are valuable assets for the courses. The following textbooks are strongly recommended: For Study Design (CC01): Epidemiology an Introduction, Kenneth Rothman. (ISBN 13: ) For Biostatistical Methods I: Basic Principles, previously known as Classical Methods for Data-Analysis (CC02): Statistical Methods in Medical Research, P. Armitage, 4 th edition (ISBN 10: / ISBN 13: ) or An Introduction to Medical Statistics, Martin Bland, 3 rd edition (ISBN 10: / ISBN 13: ). You can buy each of these books at Selexyz Donner, the bookstore at Lijnbaan 150 (in the center of Rotterdam). 2.4 Availability of standard computer software At Erasmus MC: SAS for Windows SPSS for Windows Various standard applications such as Microsoft Office and internet and programs All other applications available through the network Helpdesk Computer Support: icthelpdesk@erasmusmc.nl / Phone: Erasmus MC and Netherlands Institute for Health Sciences 8
11 Health Sciences & Clinical Research for Medical Students Time table Preliminary Programme Research Masters Health Sciences and Clinical Research Summer 2012 Introductory courses Erasmus Summer Programme ECTS Dates Time Location Principles in Research in Medicine and Epidemiology (ESP01) Aug Daily from to hours Woudestein, Rotterdam Clinical Decision Analysis (ESP04) Aug Daily from to hours Woudestein, Rotterdam Methods of Clinical Research (ESP10), or if you have attended KOW2, theme 16 Methods of Public Health Research (ESP11) Aug Daily from to hours Woudestein, Rotterdam Markers and Prognostic Research (ESP62) Aug Daily from to hours Woudestein, Rotterdam The Practice of Epidemiologic Analysis (ESP65) Aug Daily from to hours Woudestein, Rotterdam Social Epidemiology (ESP61) Aug Daily from to hours Woudestein, Rotterdam Fall 2012 Minor Ever thought of doing research? ECTS Dates Examination/Re-exam Location Study Design (CC01) 3 21 Sep 21 Sep Re-exam: 9 Jan 2013 Erasmus MC, Rotterdam Biostatistical Methods I: Basic Principles (CC02) 24 Sep 19 Oct 19 Oct Re-exam: 11 Jan 2013 Erasmus MC, Rotterdam Further specific Minor programme Oct - Nov Attendance and assignments. Erasmus MC, Rotterdam Research Orientation rsearch area Nov 2012 Aug 2013 Advanced courses - Seminars Seminars Nov 2012 Aug When you have attended this programme you receive an exemption of 10 ECTS (for CC01 and CC02) in your Research Master programme (Please note that this is NOT the number of ECTS for the minor in your Bachelor in Medicine.). 9 Study Guide
12 3. Research Master Programmes option 1 and 2 In this chapter general information will be given about the courses and research training of the Research Master programmes Health Sciences and Clinical Research (BaMa curricula). The programmes can be combined with the regular medical curriculum at Erasmus MC. You can choose between two options: attend the main part of the research master before your internships or co-schappen (option 1) or after your internships (option 2). If you start the Research Master programme in August 2012 (and the preliminary programme in 2011), you have to choose between the two options before 1 October Please also inform NIHES of your choice, by ing the NIHES Administrative office, so we can enrol you in your programme. Information on these programmes you can find in chapter 4 (Health Sciences) and 5 (Clinical Research). 3.1 Schedule & combination of the programme with the regular medical curriculum The Research master programme Clinical Research or Health Sciences can be combined with the medical curriculum at Erasmus MC. This is shown in the figures on pages 13 to 17. The programme for option 1 is described in table 1 on page 14 for the first year of the Research Master (this is also year I of your Master of Science in Medicine). The programme for option 2 is described in table 2 on page 17 for the first year of the Research Master (this is year 3 of your Master of Science in Medicine). The MSc Health Sciences programme option 1 starting in 2012 has been changed slightly with respect to the previous year: students do not attend the course Clinical Epidemiology CE02, but attend the Erasmus Winter Programme in their first Research Master year. Students who have chosen option 1 and started in 2011 (preliminary programme in 2010), attend the course Clinical Epidemiology (CE02) in their second year instead of the Erasmus Winter Programme in their first year (see page 15). Erasmus Summer Programme no 2 takes place during the summer holidays. Research Seminars run parallel to the medical curriculum. Health Sciences students receive a seminar booklet in which they can register their seminars. Clinical Research students can register their seminars in their Personal Education Programme (PEP), see chapter 5 for details. To tailor the programme of your choice to your interests and professional needs, you may select advanced elective courses (between February and June) organized by NIHES. In the schedules on page 14, 15 and 17 you can find the number of ECTS you can choose. You have to choose courses in consultation with your advisor and/or tutor. A three week visit abroad to Harvard School of Public Health or Johns Hopkins University will be organized June and July. 3.2 Programme information Though most courses are given at Erasmus MC or at Erasmus University Woudestein campus in Rotterdam, some are given in Utrecht and some others in Amsterdam. For all courses in your programme except the courses in the Erasmus Summer Programme you will receive a letter containing details about the course location, the exact date and time of the lectures, date of the examination, relevant literature, etc.. You will receive this letter at least one week before the start of the course and receive access to your online course materials. 3.3 Course exemptions from courses of your Research Master programme Successful completion of KOW2 Ever thought of doing research? counts for an exemption of 2.8 ECTS in your Research Master programme. Students who did not attend KOW2 Ever thought of doing research? need to attend 2.8 ECTS elective courses in the research master programme. They may do so by attending courses in the Erasmus summer programme after their first research master year, and/or by attending advanced electives during the winter/spring period. Erasmus MC and Netherlands Institute for Health Sciences 10
13 Health Sciences & Clinical Research for Medical Students Successful completion of the minor Ever thought of doing research? results in exemption from the courses Study Design (CC01) and Biostatistical Methods I: Basic Principles 2 (CC02) in the Research Master programme (10 ECTS in total). By attending the Erasmus Summer Programme before the minor you will receive 4.2 ECTS in the Research Master programme. To be exempted from another course (or courses), you have to send a motivation and formal written request before 1 August 2012.Your request should include the following: 1. the titles of the NIHES courses you want to be exempted from and 2. per course you want to be exempted from: a list of course titles, including course descriptions and literature used, of the corresponding courses you already successfully passed in a previous programme. You should send your request to NIHES for the attention of Mrs Astrid Vrakking, p/a NIHES, Educational Support Center, (room Ee302). Please note that all information should be in English (or Dutch)! You can find detailed information on the courses you can be exempted from at the NIHES intranet: Course exemptions from courses of your Master of Science in Medicine For exemptions for the medical programme, a request should be handed in to the Examination Board of Medicine. It is the responsibility of the student to take care of these exemptions. Upon successful completion of all courses mentioned below, you can be exempted from thema Master 1a Methoden van klinisch en epidemiologisch onderzoek of your Master of Science in Medicine. For students who passed these courses after their first exam, NIHES will send a request to the Examination Board of Medicine. - Study Design (CC01); - Biostatistical Methods I: Basic Principles (CC02); - Clinical Trials (ESP14); - Principles of Genetic Epidemiology (ESP43); - Case-control Studies (ESP40); - History of Epidemiologic Ideas (ESP53) ): - Conceptual Foundation of Epidemiologic Study Design (ESP38): - Health Economics (ESP25) The courses above apply to students who started their Master of Science programme in For previous years check the Study Guide Upon completion of the research project for your Research Master programme, you may request for exemption of the research period in your medicine programme (keuzeonderzoek), as well as for the elective internship (keuze-coschap) 3.5 Course evaluations Evaluation will take place at the end of all courses. Please fill out these forms and hand them in on the last day of the course. Your input is very valuable and consistently helps us improve our courses. 3.6 Cancelling your participation in a course If you are unable to attend a course, please notify the NIHES programme officers at the Educational Support Center in writing at least two weeks before the start of the course. An administration fee of 50 will be charged for course cancellations made less than two weeks before the start of the course 3. 2 Biostatistical Methods I: Basic Principles (CC02) was previously known as Classical Methods to Data-analysis (CC02). 3 Please note that graduation is possible only when all invoices have been paid. 11 Study Guide
14 3.7 Confidential counsellor NIHES confidential counsellor Ed van Beeck, MD PhD Phone: Erasmus MC and Netherlands Institute for Health Sciences 12
15 Health Sciences & Clinical Research for Medical Students 13 Study Guide
16 Table 1 - start 2012 option 1 Programme, option 1: Research Master and research before internships Year 2 Bachelor in Medicine Preliminary programme HS and CR ECTS Research Master Courses Research Total January/ February Year 3 Bachelor in Medicine August KOW2 Ever thought of doing research (EWP01 Erasmus Winter Programme)/ or 2,8 ECTS (10 days) electives in MSc programme Preliminary HS CR 3 weeks Erasmus Summer programme, 2,8 4,2 September-October October-August October-August Minor Ever thought of doing research ( CC01 and CC02) 10 Orientation research area Seminars total ECTS preliminary programme Year 1: Master in Medicine First year research master HS and CR August-August 16 Seminars (year 1) 3 August Courses Erasmus Summer Programme (3 weeks) 4,2 October/March: Theme 1.b the patient February Orientation research area (2 weeks) 2,8 February-March EWP: Clinical Epidemiology (4 weeks) 4,6 January-June Advanced elective courses (2 weeks) 2,8 March-April Development research protocol (6 weeks) 8,4 May-August Research period 1 (6 weeks) 8,4 June-July Courses Harvard/Johns Hopkins (3 weeks) 4,2 Year 2: Master in Medicine Second year MSc HS and CR August-August 16 Seminars (Year 2) 3 November-December SC07 Scientific writing in English for Publication 2 November-December EP03 Modern statistical Methods (3 weeks) For HS students compulsory, for CR students elective, this course may be replaced by 15 days of 4,2-4,3 electives January-February Advanced topics in Clinical Research (3 weeks Erasmus Winter Programme with exams) 5,4 January-June Advanced elective courses (2 weeks) 2,8 Throughout the year Research period year 2 (33 weeks), (including presentation and symposium) 47,2 Internships Year 3 and 4: Master in Medicine Internships until April Total ECTS Research Master 53,2 66,8 120 Erasmus MC and Netherlands Institute for Health Sciences 14
17 Health Sciences & Clinical Research for Medical Students Table 2 - start 2011 option 1 Programme, option 1: Research Master and research before internships Year 2 Bachelor in Medicine Preliminary programme HS and CR ECTS Research Master Courses Research Total January/ February Year 3 Bachelor in Medicine August KOW2 Ever thought of doing research (EWP01 Erasmus Winter Programme)/ or 2,8 ECTS (10 days) electives in MSc programme Preliminary HS CR 3 weeks Erasmus Summer programme, 2,8 4,2 September/October October-August October-August Minor Ever thought of doing research ( CC01 and CC02) 10 Orientation research area Seminars total ECTS preliminary programme Year 1: Master in Medicine First year research master HS and CR August-August 16 Seminars (year 1) 3 August Courses Erasmus Summer Programme (3 weeks) 4,2 September Orientation research area (3 weeks) 4,2 October/March: Theme 1.b the patient January to June Advanced elective courses 2,8 March/April Development research protocol (4 weeks) 5,7 May-August Research period 1 (12 weeks) 16,8 June/July Courses Harvard/Johns Hopkins (3 weeks) 4,2 Year 2: Master in Medicine Second year MSc HS and CR August-August 16 Seminars (Year 2) 3 October CE02 Clinical Epidemiology (4 weeks) 5,7 November/December SC07 Scientific Writing in english for Publication 2 November/December EP03 Modern statistical Methods (3 weeks) For HS students compulsory, for CR students elective, this course may be replaced by 15 days of 4,2-4,3 electives January/ February Advanced topics in Clinical Research (3 weeks Erasmus Winter Programme with exams) 5,4 January to June Advanced elective courses (2 weeks) 2,8 Throughout the year Research period year 2 (29 weeks), (including presentation and symposium) 41 Internships Year 3 and 4: Master in Medicine Internships until April Total ECTS Research Master 54,3 65, Study Guide
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19 Health Sciences & Clinical Research for Medical Students Table 3 option 2 Programme, option 2: Research Master and research after internships Year 2 Bachelor in Medicine Preliminary HS and CR ECTS Research Master Courses Research Total January-February Year 3 Bachelor in Medicine KOW2 Ever thought of doing research (EWP01 Erasmus Winter Programme)/ or 2,8 ECTS (10 days) electives in MSc programme Preliminary HS CR 2,8 August 3 weeks Erasmus Summer programme, 4,2 September-October October-August October-August Minor Ever thought of doing research ( CC01 and CC02) Orientation research area Seminars 10 total ECTS preliminary programme Year 1: Master in Medicine First year research master HS and CR August-August 16 Seminars (year 1) 3 August Courses Erasmus Summer Programme (3 weeks) 4,2 October-February: Theme 1.b The Patient February-March Internships Year 2: Master in Medicine Erasmus Winter Programme: Clinical Epidemiology (4 weeks) 4,6 Internships Year 3: Master in Medicine Internships September/December Year 1 research Master MSc HS and CR (continued) January Orientation research area (2 weeks) 2,8 January -February Development research protocol (6 weeks) 8,4 January -June Advanced elective courses (2 weeks) 2,8 February - Mar Advanced topics in Clinical Research (three weeks Erasmus Winter Programme) 5,4 April-August Research period (16 weeks) 19,6 June-July Courses Harvard/Johns Hopkins (3 weeks) 4,2 Year 4: Master in Medicine Year 2 research Master HS and CR August-August 16 Seminars (Year 2) 3 November-December Scientific Writing in English for Publication (SC07) 2,0 November-December EP03 Modern statistical Methods (3 weeks) For HS students compulsory, for CR students elective 4,2-4,3 and may be replaced by 15 days of other electives January-June Advanced elective courses (2 weeks) 2,8 Throughout the year Research period year 2 (28 weeks), (including presentation and symposium) 36,0 Total ECTS Research Master 53,2 66, Study Guide
20 4. Research project & time table Research Master Health Sciences In this chapter an overview of the courses and information on the research project of the Research Master in Health Sciences for Master students in Medicine is given. Chapter 5 discusses the Research Master Clinical Research. The following pages include the timetables for Option 1 of the Research Master in Health Sciences programme. Please note that the programme is subject to change. You are advised to regularly check for up-to-date course information. Students who are going to do their research project at the Genetic Epidemiology department will have to attend specific genetic courses during the Erasmus Summer Programme, and in spring and fall. The specific programme outline will be determined together with the Programme Coordinator, Astrid Vrakking. 4.1 Research project An important part of the programme is dedicated to your research project. The programme covers a broad and varied range of research, from major neurological and cardiovascular diseases to the endocrinological determinants of diseases; from paediatric studies to end-of-life decisions in medical practice; and from the social determinants of health and disease to the side effects of drugs. Research areas for students Clinical Research differ form those for students Health Sciences. The research areas and research groups of both programmes are mentioned in our brochure Research Themes: Research Master Programmes Health Sciences and Clinical Research. This brochure is available on the NIHES website. You will work on your research project under the guidance and supervision of the personal tutor to whom, as described in the next paragraph, you are assigned at the start of your programme. All tutors are senior faculty members at the Erasmus University. Each has considerable experience in one or more specific research subjects. On the basis of your research ambitions, the selection committee will choose a field of research and a tutor. The tutor will receive your curriculum vitae. From that point on, it is up to your tutor and you to arrange your further collaboration. The primary tasks of the tutor are: to support and supervise the student during the research phase; to keep track of the content of the student s training programme; to meet the student for at least an hour at least once every two weeks; to arrange for the student to be provided with a desk and computer, usually at the tutor s own department; to arrange that his or her student receives all the necessary computer software, i.e. in addition to the standard software available (see below); to monitor and report on the student's progress and results; to assess the student's research project. Practical research As soon as you and your tutor have decided on the topic for a research project, you will start working on your research project. You will be required to formulate a research proposal and design a study. While it is possible for you to collect and analyse data yourself, in most cases you will carry out your project using existing data available at the department. You will work closely together with the research group at your tutor s department, and have full access to the computer facilities available for data management and analysis. As stated above, you will regularly meet with your tutor, especially in the beginning. The research training starts with formulating a research question and writing a research proposal. This proposal should include, among other things, the research objectives, the study design, the data-collection and the data-analysis procedure, and your time schedule. The research topic you choose, will determine the department or research group you will be assigned to and where you will be carrying out your research project. You will start working on your research project after approval of your proposal by your personal tutor. You will write a scientific paper under the guidance of your tutor. Erasmus MC and Netherlands Institute for Health Sciences 18
21 Health Sciences & Clinical Research for Medical Students Your research proposal As a first-year student,you have to write a research proposal in collaboration with your tutor. If you are a first year Research master student, following option 1, you should hand in your proposal, signed for approval by your tutor, to the NIHES Administration, Educational Support Center (Fe209) for the attention of Mrs Astrid Vrakking before Tuesday 15 May Please note that this deadline will be strictly maintained. The research proposal should comprise of a maximum of 4 pages (A4, single-spaced text) and contain the following information: objectives; project group; study design; data-collection procedure; data-analysis procedure; time schedule. Presenting your research Symposium Each year, a symposium for medical students who are planning to finish their research project for the Research Master Health Sciences or Clinical Research will be organized. Students have to present their research project. Tutors and advisors are invited too. The date will be announced. Research department Students are also required to present their research project to their tutor s research group: the tutor needs to confirm, in writing, that the presentation took place. Please note that it is your responsibility to ensure that we receive this confirmation no later than 5 weeks before your graduation. The confirmation should be addressed to the NIHES Administration, Educational Support Center (Fe209) for the attention of Mrs Astrid Vrakking or via to nihes@erasmusmc.nl. Your thesis Handing in your thesis You are required to write and hand in one draft of a research paper that is submittable to an international peer reviewed scientific journal. Your paper should be approved and signed by your tutor. The deadline for submitting the paper is 5 weeks before the graduation ceremony (See also chapter 7). Your research project may eventually lead to your submission of a paper (i.e. an article) to an international peer reviewed scientific journal. Publishing and presenting your research project Once your research paper has been published, a copy should be sent to the NIHES Administration, Educational Support Center (Fe209). Furthermore, Health Sciences students must always mention or refer to NIHES when presenting or publishing their research findings. 19 Study Guide
22 Time table Research Master Health Sciences for Master students in Medicine, option 1 and option 2 4 See also Table 1 on page 14 and Table 3 on page 15. Start 2012 First year Summer 2012 Introductory courses Erasmus Summer Programme ECTS Dates Time Location Clinical Trials (ESP14) Aug Daily from 8.45 to hours Woudestein, Rotterdam Principles of Genetic Epidemiology (ESP43) Aug Daily from to hours Woudestein, Rotterdam Case Control Studies (ESP40) Aug Daily from 8.45 to hours Woudestein, Rotterdam History of Epidemiologic Ideas Aug Daily from to hours Woudestein, Rotterdam Conceptual Foundation of Epidemiologic Study Design (ESP38) Aug Daily from 8.45 to hours Woudestein, Rotterdam Health Ecenomics (ESP25) Aug Daily from to hours Woudestein, Rotterdam CHRISTMAS BREAK 22 December January 2013 Winter / Spring 2013 Advanced courses ECTS Dates Examination/Re-exam Location Intervention Research and Clinical Trials (EWP04) Feb 1 Mar 22 Mar, re-exam: 8 May Erasmus MC Diagnostic Research (EWP05) Mar Assignment(s) during course Erasmus MC Prognostic Research (EWP16) Mar 22 Mar, re-exam: 8 May Erasmus MC Advanced Topics in Decision Making in Medicine (EWP02) Mar Assignment(s) during course Erasmus MC Advanced elective courses 5.6 to 7.2 Jan Jun You may select 20 to 25 days days of elective courses. (If you have followed KOW2 Ever thought of doing research in your Bachelor Medicine, you need to follow 10 to 15 days (2.8 to 4.2 ECTS) Harvard/Johns Hopkins 4.2 Jun - Jul USA (3 weeks) 4 Option 2 students, who started in 2012, attend this programme until the Erasmus Winter Programme in Erasmus MC and Netherlands Institute for Health Sciences 20
23 Health Sciences & Clinical Research for Medical Students Research Orientation research area 2.8 February 2 weeks Development research protocol 8.4 Mar - May 6 weeks Research period May Aug 12 weeks Advanced courses - Seminars You are required to attend in total 32 seminars as part of your programme, obtaining 6 ECTS. 21 Study Guide
24 Time table Research Master Health Sciences for Master students in Medicine option 1 See also Table 2 on page 15. Start 2011 Second year Fall 2012 Programme specific courses and skils courses ECTS Dates Examination/Re-exam Location Clinical Epidemiology (CE02) Oct 16 Nov 16 Nov Re-exam: 18 Jan 2013 Erasmus MC, Rotterdam Biostatistical Methods II: classical regression models (EP03) Dec 21 Dec Re-exam: 8 Feb 2013 Erasmus MC, Rotterdam Scientific writing in English for Publication (SC07) and 28 Nov and 12 Dec Attendance and assignments. Erasmus MC, Rotterdam Presentation research project at mini symposium Nov/Dec 2012 CHRISTMAS BREAK 22 December January 2013 Winter / Spring 2013 Advanced courses and skills courses ECTS Dates Examination/Re-exam Location Pharmaco-epidemiology and Drug Safety (EWP03) Feb 1 Mar 22 Feb, re-exam: 8 May Erasmus MC Advanced Topics in Clinical Trials (EWP10) Mar 22 Feb, re-exam: 8 May Erasmus MC Advanced Analysis of Prognosis Studies (EWP13) Mar 22 Feb, re-exam: 8 May Erasmus MC Principles of Epidemiologic Data-analysis (EWP25) Mar 15 Mar, re-exam: 8 May Erasmus MC Advanced elective courses 2.8 Jan - Jun You may select 10 to 15 days days of elective courses Research Research period 2 Throughout the year 29 weeks Advanced courses - Seminars You are required to attend in total 32 seminars as part of your programme, obtaining 6 ECTS. Graduation Information about the formal completion of your programme and the graduation ceremony is t.b.a.. Erasmus MC and Netherlands Institute for Health Sciences 22
25 Health Sciences & Clinical Research for Medical Students 5. Research project & time table Research Master Clinical Research In this chapter an overview of the courses and information on research project of the Research Master in Clinical Research for Master students in Medicine is given. In chapter 4, information on the Research Master Health Sciences can be found. 5.1 Research project An important part of the programme is dedicated to your research project. The programme covers a broad and varied range of research, from major neurological and cardiovascular diseases to the endocrinological determinants of diseases; from paediatric studies to end-of-life decisions in medical practice; and from the social determinants of health and disease to the side effects of drugs. Research areas for students Clinical Research differ form those for students Health Sciences. The research areas and research groups of both programmes are mentioned in our brochure Research Themes: Research Master Programmes Health Sciences and Clinical Research This brochure is available on the NIHES website. Advisory Board Clinical Research Advisory Board Clinical Research consists of the following persons: Prof. A.J. van der Lely, MD PhD, Endocrinology Prof. H. Boersma, ir., PhD, Thorax Epidemiology Prof. H.A. Drexhage, MD, PhD, Immunology Prof. H. Hooijkaas, MD, PhD, Immunology L.J. Hofland, MD, PhD, Endocrinology Prof. J.F. Lange, MD, PhD, Surgery Prof. M.P. Peppelenbosch, MD, PhD, Gastroenterology & Hepatology Prof. I.P. Touw, MD, PhD, Hematology A.J.M. Verhoeven, PhD, Internal Medicine The Advisory Board Clinical Research guides the study progress of the Clinical Research students. The Board meets every few months. Furthermore, members of the Board are part of the defence committee. The selection committee will choose an advisor of the Advisory Board Clinical Research based on your research ambitions. The advisor will receive your curriculum vitae. From that point on, it is up to your advisor and you to search for a suitable research project and tutor. When you agree on a research project and tutor, please inform your NIHES programme officer at nihes@erasmusmc.nl. Primary tasks of the advisor are: to find a tutor on the basis of the students preferences and possibilities of the research group/department; to keep informed about the study progress; to answer questions and assist the student with solving problems that are not directly connected to the research project and tasks of the tutor; to be present at the symposium. Personal Education Programme (PEP) At the beginning of your Research Master you will receive a Personal Educational Plan, which is meant for you to administrate your programme. The following topics are covered in the PEP: meetings with your advisor Clinical Research and tutor, planning elective courses and performed elective courses and research seminars. Tutor You will work on your research project under the guidance and supervision of the personal tutor to whom you are assigned in discussion with your advisor. All tutors are senior faculty members at the Erasmus University. Each has considerable experience in one or more specific research subjects. The primary tasks of the tutor are: to support and supervise the student during the research phase; to keep track of the content of the student s training programme; to meet the student for at least an hour at least once every two weeks; to arrange for the student to be provided with a desk and computer, usually at the tutor s own department; 23 Study Guide
26 to arrange that his or her student receives all the necessary computer software, i.e. in addition to the standard software available (see below); to monitor and report on the student's progress and results; to report the research progress to the advisor of the Advisory Board Clinical Research; to assess the student's research project; to find an independent reviewer, preferably outside the Netherlands, to assess the final paper of the students research project; to be present at the final defence meeting of the student. Practical research As soon as you and your tutor have decided on the topic for a research project, you will start working on your research project. You will be required to formulate a research proposal and design a study. While it is possible for you to collect and analyse data yourself, in most cases you will carry out your project using existing data available at the department. You will work closely together with the research group at your tutor s department, and have full access to the computer facilities available for data management and analysis. As stated in paragraph 6.2, you will regularly meet with your tutor, especially in the beginning. The research training starts with formulating a research question and writing a research proposal. This proposal should include, among other things, the research objectives, the study design, the data-collection and the data-analysis procedure, and your time schedule. The research topic you choose, will determine the department or research group you will be assigned to and where you will be carrying out your research project. You will start working on your research project after approval of your proposal by your personal tutor and advisor. You will write a scientific paper under the guidance of your tutor. Your research proposal As a first-year student following option 1, you have to write a research proposal in collaboration with your tutor. You should hand in your proposal, signed for approval by your tutor, to the NIHES Administration, Educational Support Center (Fe209) for the attention of Mrs Astrid Vrakking before Friday 15 May Please note that this deadline will be strictly maintained. The research proposal should comprise of a maximum of 4 pages (A4, single-spaced text) and contain the following information: objectives; project group; study design; data-collection procedure; data-analysis procedure; time schedule. Presenting your research Presenting your research proposal Approximately month after handing in your research proposal, you have to present it to members of the Advisory Board Clinical Research. More information will be announced. Symposium Each year in November, a symposium for medical students who attend the Research Master of Health Sciences and Clinical Research will be organized. Students who are in the third year of their Master have to present their research project. Tutors and advisors are invited too. The date will be announced. Research department Students are also required to present their research project to theirs tutor s research group: the tutor needs to confirm, in writing, that the presentation took place. Please note that it is your responsibility to ensure that we receive this confirmation no later than five weeks before your graduation. The confirmation should be addressed to the NIHES Administration, Educational Support Center (Fe209) for the attention of Mrs Astrid Vrakking or via to nihes@erasmusmc.nl. Erasmus MC and Netherlands Institute for Health Sciences 24
27 Health Sciences & Clinical Research for Medical Students Your thesis Handing in your thesis You are required to write and hand in one research paper that is submittable to an international peer reviewed scientific journal to NIHES. Your paper should be approved and signed by your tutor. The deadline for submitting the paper is dependent of your defence. It will be announced as soon as your defence date is determined. Your research project will eventually lead to your submission of a paper (i.e. an article) to an international scientific journal. Defence of the research project You also have to defend your research paper in front of a committee with members of the Advisory Board Clinical Research and your tutor. Three dates will be announced for which you can sign in aligning with your tutor. Publishing and presenting your research project Once your article has been published, a copy should be sent to the NIHES Administration, Educational Support Center (Fe209). Furthermore, Clinical Research students must always mention or refer to Erasmus MC when presenting or publishing their research findings. Time table Research Master in Clinical Research The following pages include the timetables for the first and second year BaMa students of the Research Master in Clinical research programme. Please note that the programme is subject to change. You are advised to regularly check for up-to-date course information. 25 Study Guide
28 Time table Research Master Clinical Research for Master students in Medicine option 1 See also Table 1 on page 14. Start 2012 First year Summer 2012 Introductory courses Erasmus Summer Programme ECTS Dates Time Location Clinical Trials (ESP14) Aug Daily from 8.45 to hours Woudestein, Rotterdam Principles of Genetic Epidemiology (ESP43) Aug Daily from to hours Woudestein, Rotterdam Case Control Studies (ESP40) Aug Daily from 8.45 to hours Woudestein, Rotterdam History of Epidemiologic Ideas Aug Daily from to hours Woudestein, Rotterdam Conceptual Foundation of Epidemiologic Study Design (ESP38) Aug Daily from 8.45 to hours Woudestein, Rotterdam Health Ecenomics (ESP25) Aug Daily from to hours Woudestein, Rotterdam CHRISTMAS BREAK 22 December January 2013 Winter / Spring 2013 Advanced courses ECTS Dates Examination/Re-exam Location Intervention Research and Clinical Trials (EWP04) Feb 1 Mar 22 Feb, re-exam: 8 May Erasmus MC Diagnostic Research (EWP05) Mar Assignment(s) during course Erasmus MC Prognostic Research (EWP16) Mar 22 Feb, re-exam: 8 May Erasmus MC Advanced Topics in Decision Making in Medicine (EWP02) Mar Assignment(s) during course Erasmus MC Advanced elective courses 5.6 to 7.2 Jan Jun You may select 20 to 25 days days of elective courses in total. (If you have followed KOW2 Ever thought of doing research in your Bachelor Medicine, you need to follow 10 to 15 days (2.8 to 4.2 ECTS) Harvard/Johns Hopkins 4.2 Jun - Jul USA (3 weeks) Erasmus MC and Netherlands Institute for Health Sciences 26
29 Health Sciences & Clinical Research for Medical Students Research Orientation research area 2.8 February 2 weeks Development research protocol 8.4 Mar - May 6 weeks Research period May Aug 12 weeks Advanced courses - Seminars You are required to attend in total 32 seminars as part of your programme, obtaining 6 ECTS. 27 Study Guide
30 Time table Research Master Clinical Researhc for Master students in Medicine option 1 See also Table 2 on page 15. Start 2011 Second year Fall 2012 Programme specific courses and skils courses ECTS Dates Examination/Re-exam Location Clinical Epidemiology (CE02) Oct 16 Nov 16 Nov Re-exam: 18 Jan 2013 Erasmus MC, Rotterdam Optional:Biostatistical Methods II: classical regression Dec 21 Dec Re-exam: 8 Feb 2013 Erasmus MC, Rotterdam models (EP03), for Clinical Research students this is an elective and may be replaced by 15 days of other electives 4.3 Scientific writing in English for Publication (SC07) and 28 Nov and 12 Dec Attendance and assignments. Erasmus MC, Rotterdam Presentation research project at mini symposium Nov/Dec 2012 CHRISTMAS BREAK 22 December January 2013 Winter / Spring 2013 Advanced courses and skills courses ECTS Dates Examination/Re-exam Location Pharmaco-epidemiology and Drug Safety (EWP03) Feb 1 Mar 22 Feb, re-exam: 8 May Erasmus MC Advanced Topics in Clinical Trials (EWP10) Mar 22 Feb, re-exam: 8 May Erasmus MC Advanced Analysis of Prognosis Studies (EWP13) Mar 22 Feb, re-exam: 8 May Erasmus MC Principles of Epidemiologic Data-analysis (EWP25) Mar 15 Mar, re-exam: 8 May Erasmus MC Advanced elective courses 2.8 Jan - Jun You may select 10 to 15 days days of elective courses Research Research period 2 Throughout the year 29 weeks Erasmus MC and Netherlands Institute for Health Sciences 28
31 Health Sciences & Clinical Research for Medical Students Advanced courses - Seminars You are required to attend in total 32 seminars as part of your programme, obtaining 6 ECTS. Graduation Information about the formal completion of your programme and the graduation ceremony is t.b.a.. 29 Study Guide
32 6. Examination Procedure and Rules TER and Examination Board You can find the examination procedures and rules in the Teaching and Examination Regulations (TER) Research Master Programmes on the NIHES intranet: http//nihes.nl/intranet. Details on the Examination Board can also be found on the NIHES intranet. 6.2 Attainment targets Training With the exception of the skills courses and most elective courses all courses in the core curriculum culminate in an examination. For a candidate to pass an examination he or she may not score less than satisfactory, i.e. a grade lower than 5.5. Skills courses and advanced elective courses There are no examinations for the skills courses or most electives. Instead, a pass grade is required. To obtain this, students have to attend the courses. Only then will the course be stated on your list of grades. A student is only allowed to be absent from a course for 20% maximum if a motivated request is granted by one of the programme officers or programme coordinators of NIHES. Research The research project has to culminate in a research paper; the entire paper, including all parts or paragraphs, has to be ready for submission to an international English-language scientific journal. The journal has to have an impact factor and a good reputation in its field. The conventions of The Journal of American Medical Association (JAMA) apply as author's rules: this means that the student is usually named as first author and the tutor as second in the research paper. The names should also be stated of 1. the institute where the research was carried out, 2. the Netherlands Institute for Health Sciences, and, if applicable, 3. the student's home institute. In the event of problems during the research phase, student and tutor should both report to one of the programme coordinators no later than the March before graduation. All tutors assess their students on the basis of the student s commitment and motivation, and on the knowledge and creativity they have demonstrated during the research period. Final assessment of the research paper is expressed as one of the following levels: Outstanding (9-10) Excellent (8-8.9) Very Good (7-7.9) Good (6-6.9) Satisfactory ( ) Unsatisfactory (4-5.4) Poor (1-3.9) No later than the beginning of August in the year of graduation, the tutor will write and submit the assessment report in which he or she gives formal permission for a degree to be awarded to his or her student. If the outcome is insufficient (less than 5.5), the student will not be able to graduate. The paper has to be assessed by the director. 6.3 Students overall rights and duties The following rights and duties apply to all the students. Each student may start his or her research project only when all compulsory courses have been passed (programme coordinators alone are authorized to decide on deviations from this rule). 5 For full details, see the Teaching and Examination Rules. Information is available at the NIHES administrative office, Educational Support Center or at Masters Erasmus MC and Netherlands Institute for Health Sciences 30
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