UNIVERSITY SENATE REVIEW AND CONSULTATION SUMMARY SHEET

Transcription

1 UNIVERSITY SENATE REVIEW AND CONSULTATION SUMMARY SHEET Proposal Title: PhD in Epidemiology and Biostatistics Proposal Contact: Dr. Richard Kryscio, Chair, Department of Biostatistics College of Public Health 121 Washington Avenue, Room 200 CAMPUS 0003 Phone: Becki Flanagan, Academic Affairs Instruction: To facilitate the processing of this proposal please identify the groups or individuals reviewing the proposal, identify a contact person for each entry, provide the consequences of the review (specifically, approval, rejection, no decision and vote outcome, if any) and please attach a copy of any report or memorandum developed with comments on this proposal. Reviewed By Contact person Consequences of Review Date of Proposal Review Review Summary Attached? Council on Post-Secondary Education James Applegate Approved 12/19/2006 Yes Academic Affairs Committee Marta Mendiondo, Chair Approved 6/17/08 Yes Faculty Council Glyn Caldwell, Chair Approved 6/26/08 Yes Office of Academic Affairs Linda Alexander, Associate Dean Approved 7/18/08 Yes

2 UNIVERSITY OF KENTUCKY D r e a m C h a l l e n g e S u c c e e d COLLEGE OF PUBLIC HEALTH M E M O R A N D U M TO: FROM: Health Care Colleges Council Linda A. Alexander, EdD Associate Dean for Academic Affairs SUBJECT: New Program Proposal PhD in Epidemiology and Biostatistics DATE: July 18, 2008 It is the intention of the College of Public Health to begin offering a new degree program a PhD in Epidemiology and Biostatistics. In November 2006, our college applied to the Kentucky Council for Post-Secondary Education for permission to develop a proposal for this new degree. The CPE posed several questions of us, which we answered, and on December 19, 2006, Provost Subbaswamy received notification that the CPE granted permission for us to develop the program. This degree is an integrative doctoral program that will equip future researchers with substantial methodological and quantitative skills in the the disciplines of epidemiology and biostatistics, as well as advanced research-oriented training in both theory and methodology. Practicing MDs, DMD, PharmDs, and other health professionals who are interested in conducting populationbased research and clinical trials will be the targeted audience for the degree; Master s-level graduates in the areas of psychology, computer science, engineering, business, biology, or chemistry may also find the degree program attractive. After the full proposal was completed, it was reviewed and approved by the Academic Affairs Committee and the Faculty Council, according to our college s established bylaws. Further information about this course can be obtained by contacting Dr. Richard Kryscio at or via at [email protected]. Office of the Dean 121 Washington Ave., Suite 112 Lexington Kentucky (859) fax (859) An Equal Opportunity University

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9 MEMORANDUM To: Faculty Council From: Marta S. Mendiondo Chair, Academic Affairs Committee Date: June 17, 2008 The Academic Affairs committee approved the new program request for the PhD in Epidemiology and Biostatistics, which includes several new course proposals and course changes.

10 TO: CC: CC: FROM: Linda Alexander Associate Dean for Academic Affairs Marta Mendiodo Chair, Academic Affairs Committee Richard Kryscio Thomas Tucker Glyn G. Caldwell Chair, Faculty Council DATE: June 26, 2008 SUBJECT: Approval of the joint Doctor of Philosophy Degree in Biostatistics and Epidemiology On June 26, 2008, the Faculty Council of the College of Public Health unanimously approved the joint Doctor of Philosophy Degree in Biostatistics and Epidemiology.

11 New Program Request

12 REQUEST FOR A NEW PROGRAM Degree title: PhD in Epidemiology and Biostatistics Major title: Epidemiology and Biostatistics Option: N/A Major code in SIS: Primary College: College of Public Health CIP Code: Biostatistics Epidemiology Accrediting Agency: N/A Contacts: Marta S. Mendiondo marta@ .uky.edu x274 Richard J. Kryscio [email protected] Thomas C. Tucker [email protected] x225 I. Abstract The proposed PhD program in epidemiology and biostatistics is intended to prepare professionals for a career in conducting population-based research and clinical trials. It is a unique program which strongly emphasizes the acquisition of applied skills in the complementary fields of epidemiology and biostatistics, as well as the theoretical foundations of these disciplines. Graduates of this program will be prepared to address the practical challenges of conducting population-based and clinical, translational research in the multidisciplinary work environments of academia, government, and industry. Unlike traditional doctoral preparation in either discipline alone, this program will leverage the unique collaborative environment between the departments of Biostatistics and Epidemiology in the College of Public Health. The essentially strong cross-training and mentoring nature of the program is intended to develop independent researchers who will be skilled in designing and conducting studies as well as analyzing, and interpreting the results from increasing variety of designs and databases in the public health and medical research domains. This is intended to be an integrative doctoral program which prepares future researchers who will have substantial methodological and quantitative preparation in the unique domains of these two disciplines. This program is intended to provide advanced, research-oriented training in both theory and methodology. Scholars will be required to undertake a doctoral dissertation, following the completion of required course work and examinations, which will be of the caliber for publication as independent research in respected biostatistical, epidemiological, or statistics journals. Page 1

13 AUDIENCE The target audience for this program will include students with an appropriate prior bachelor s or masters degree (in biostatistics, epidemiology, statistics, health services research, mathematical sciences, or a related field) with a prior mathematical training to include two semesters of calculus (univariate differential and integral which can be fulfilled by MA 113 and MA 114) and statistical methods (STA 580). Practicing health care professionals (MDs, DMDs, PharmDs, etc) who are interested in pursuing independent, doctoral level, research careers will be targeted for the program. Master s graduates from psychology, computer science, engineering, business, biology, or chemistry may also find this degree program attractive. The program will prepare students for research oriented careers in population based studies and clinical research studies including clinical trials. There is a severe shortage of doctoral level graduates with training in epidemiology and biostatistics. This program is unique since it requires students to acquire proficiency in both areas. A terminal master s degree (MS) in epidemiology is embedded into the program. NEED There is an increasing need for research-oriented health professionals who will be qualified to conduct population-based research and clinical trials in the next several decades. The production of doctoral-prepared biostatisticians has remained steady while the demand has increased markedly with increasing opportunities in the biomedical research enterprise. At present, there is both a shortage of biostatisticians with some training in biology and disease process knowledge, as well as epidemiologists with an understanding of the new developments in the biostatistics, data management, and clinical trials research. There has been an intense demand for scientifically trained (subject matter) data analysts who can address the issues in conducting studies which include large amounts of complex data. The neurosciences, surveillance, and computational biology are expected to be growth areas which will demand the complex, integrated skill set of a new group of professionals. Although the economy is slowing down, Smith Hanley reported that Quantitative Professionals are secure... Recruiters at Smith Hanley have not seen signs of slowdowns in our markets... As many corporations are realizing the limitations of outsourcing their analytics overseas, they have turned to domestic consulting... This leads to a visible growing demand for quantitative professionals in consulting environments.. (Burtch, Linda. Recession Talk Exaggerated re Analytical Job Market. Smith Hanley Trends 2008.) Page 2

14 II. Program Description Competencies The following competencies for the MS in Epidemiology are based on the core courses for the degree: 1. Understand the interface between biostatistics and epidemiology 2. Demonstrate advanced proficiency to apply concepts and methods from these disciplines jointly. 3. Demonstrate the ability to review and critically evaluate the literature in a substantive area of research, be able to identify gaps in knowledge and be able to formulate original research hypotheses or statements 4. Evaluate the strengths and limitations of epidemiologic reports. 5. Draw appropriate inferences from data. 6. Communicate research results orally and in writing to lay and professional audiences. 7. Demonstrate an understanding of concepts of probability and statistical inference as they apply to problems in public health. 8. Demonstrate proficiency in using computing tools commonly encountered in epidemiology and biostatistics. 9. Understand the principles of epidemiologic study design and be able to calculate the appropriate epidemiologic measures for most typical designs. 10. Become proficient at and be able to evaluate the strengths and limitations of advanced designs including multivariate linear models, generalized linear models, longitudinal models, mixed effects models, and survival models both parametric and nonparametric. 11. Understand the principles of chronic and infectious disease epidemiology. 12. Demonstrate an understanding of research methods used in epidemiology and biostatistics. 13. Demonstrate knowledge of the public health system in the commonwealth and the country. Curriculum Students will complete a minimum of 62 credit hours of study and a dissertation research. All requirements must be completed within the number of years determined by the graduate school (8 years at this time) of undertaking the program. The core curriculum consists of 39 hours comprising thirteen courses, including several courses in epidemiology and biostatistics, and a one-credit-hour course that will serve as a broad introduction to public health. Students will also complete a minimum of 15 credit hours of electives (including at least two epidemiology courses and two 700 level biostatistics courses), all of which must be approved by the student s dissertation committee and the DGS. In addition, the student must complete four one-hour seminars within the first three years and three semesters of dissertation credits(cph 769). Students will be required to pass a Comprehensive Exam between the Fall and Spring semesters of their second year in the program. Also, students must pass a Qualifying Page 3

15 Oral Exam before beginning their residency credits. Students must complete at least two semesters in the 2 credit hour residency course, for a minimum of 4 hours. All students will be required to pass a written examination after the completion of three semesters of coursework and an oral exam before proceeding with the dissertation research. The dissertation research is expected to be an original scientific project which is integrative in the sense that either advanced biostatistical methods are applied to a population-based epidemiologic study of sufficient size and appropriate design or original theoretical research is undertaken in biostatistics with applied research problems. Faculty will encourage a dissertation document which shall produce at least two manuscripts which will be of publishable quality, as well as an integrative literature review of the area of research. The scope of the project shall demonstrate independence, mastery of research skills, thoughtful reflection of the results, and contribute to new knowledge in the field of investigation. This program will require the formation of a doctoral committee. No fewer than 4 persons shall constitute the doctoral committee. A least 2 of the members must be full members of the graduate school. At least 3 of the 4 members must be faculty from the Departments of Epidemiology and Biostatistics (minimum of 1 from each department) in the College of Public Health. It is expected that the committee will meet on a regular basis to track student progress. Pre-requisites Bachelor s Degree Calculus: Univariate Differential and Integral Calculus (may be fulfilled by MA 113, MA 114) One course in Life Sciences STA 580: Biostatistics 1 Applications for admission to the PhD program will be reviewed by the admissions committee. This committee will include the program s DGS and representatives from the Biostatistics and Epidemiology Departments in the College of Public Health. All admitted students must satisfy all the requirements of the Graduate School. Core Curriculum (39 hours) BST 675 Biometrics I BST 676 Biometrics II BST 639 Computing Tools BST 760 Advanced Regression BST 761 Time to Event Analysis BST 762 Longitudinal Data Analysis CPH 701 Current Issues in Public Health CPH 605 Intro Epidemiology CPH 712 Adv. Epidemiology EPI 714 Epidemiologic Study Design CPH 711 Chronic Disease Epidemiology EPI 715 Research Methods in Epi & Bio EPI 711 Chronic Disease Epidemiology Page 4

16 Seminars (4 hours) Students must take 4 semesters of 1 credit hour seminar in the first 3 years (CPH 786). Electives (15 hours) 5 courses- At least 2 epidemiology courses and level Biostatistics courses. Must be approved by the student s dissertation committee. Residency (4+ hours) CPH 767 (2 credit hour course) will be taken each semester until they have completed and defended the dissertation. This course must be taken a minimum of two semesters. Dissertation Research Defense Students will present their dissertation research defense, presumably at the end of year four. 62 credit hours + Dissertation Research Defense Typical Schedule of Classes for Full Time Student Fall Year 1 CPH 605 Intro Epidemiology BST 675 Biometrics I BST 639 Computing Tools Year 2 EPI 714 Epidemiologic Study Design BST 761 Time to Event Analysis EPI 716 Infectious Disease Epidemiology CPH 701 Current Issues in Public Health Spring CPH 712 Adv. Epidemiology BST 676 Biometrics II BST 760 Advanced Regression EPI 715 Research Methods in Epi & Bio BST 762 Longitudinal Data Analysis CPH 711 Chronic Disease Epidemiology CPH 786 Seminar : 4 semesters of 1 credit hour seminar must be taken in the first 3 years Comprehensive Exam (between Fall and Spring of year 2) Qualifying Oral Exam (before residency credits) Dissertation Research Defense after year 4 Year 3 Elective Elective Elective Year 4 CPH 767 Residency Credit Elective Elective CPH 767 Residency Credit Dissertation Research Defense Page 5

17 List of Core Courses BST 675 BST 676 CPH 605/ PM 720 CPH 712 BST 639/ CPH 639 BST 760 Biometrics I (4) This course, the first of a two-semester sequence in biometrics, introduces probability, discrete random variables, continuous random variables, and sampling distributions. Biometrics II (4) This course, the second of a two-semester sequence in biometrics, introduces techniques for constructing and evaluating point estimators, hypothesis testing procedures, and interval estimators. Epidemiology (3) In this course students are taught the principles and methods of epidemiologic investigations, research methodology, and statistical integration. Major topics include etiologic factors of disease and injury, the distribution of health problems within populations, levels of prevention, and the concept of risk. The design of retrospective, crosssectional and prospective studies are examined to illustrate odds ratio, relative risk, life tables, and person-years. Students are required to complete and submit a research proposal, present a topic paper, and serve as a co-facilitator for an article discussion. Advanced Epidemiology (3) Provides an in-depth understanding of the evidence needed to show causal relationships and epidemiologic theories, concepts and tools used to establish causal relationships. Computing Tools (3) Introduction to statistical and epidemiologic software technologies commonly used for the collection, management, and analysis of data. It is designed to prepare first year students for further coursework and dissertation research. Advanced Regression (3) This course provides an introduction to theoretical methods and applications of linear and generalized linear models. Regression methods for normally distributed outcomes will provide a discussion of experimental design, design matrices, and modes of parametric inference for the linear model. Students will learn to apply these concepts in sophisticated data analysis where they will implement tools for model building and selection, variable selection, and handling categorical predictors, confounders and interactions. Additionally, students will learn polynomial regression and flexible alternatives such as weighted least squares and robust, ridge and nonparametric regression. Regression methods for non-normal outcomes (focusing on binomial and count data) will be covered in detail, providing students with foundational tools for understanding and implementing generalized linear models that are commonly used to analyze epidemiologic and public health data from various study designs including but not limited to cohort, case-control, and clinical trials. Page 6

18 BST 761 BST 762/ STA 632 EPI 715 EPI 714 CPH 711 EPI 716 Time to Event Analysis (3) Analysis of time to event data encountered in Public Health and Medicine. Survival distributions and hazard functions. Time to event analysis using Kaplan-Meier method and life-table method. Accelerated failure time model, logit model for discrete data, complementary log-log model, and proportional hazards model. Tests for goodness-of-fit, graphical methods, and residual and influence statistics. Time-dependent covariates, non-proportional hazards, left truncation, and late entry into the risk set. Sample size and power, competing risks, and time to event analysis with missing data. Longitudinal Data Analysis (3) This course presents statistical techniques for analyzing longitudinal studies and repeated measures experiments that occur frequently in public health, clinical trials, and outcomes research. This course will cover linear mixed models, generalized linear mixed models and an introduction to nonlinear models as they apply to the analysis of correlated data. Research Methods in Epidemiology & Biostatistics (3) This course builds a broad array of skills that are useful for the design and development of research protocols and funding applications for peer review, and for the analysis of resultant scientific data. Epidemiologic Study Design (3) This course provides students with advanced course material relevant to the planning and execution of epidemiologic studies of various designs. The course will consider study designs which employ routinely collected data on disease occurrence, such as would be undertaken in government agencies and health departments, and the classic etiologic study designs including the casecontrol, prospective cohort, retrospective cohort, nested case control, case-cohort, and case-crossover designs. The course will focus considerable attention on measurement methods and measurement error, borrowing examples from the subfields of epidemiology including occupational, cardiovascular, and social epidemiology. Given current interest on multilevel methods of analysis, the class will discuss approaches to designing multilevel studies. Finally, we will consider recent advances in experimental epidemiology with consideration of controlled community trials. Chronic Disease Epidemiology (3) Provides students with an overview of the risk factors associated with the most common chronic diseases, data sources available about these diseases and epidemiologic theories, concepts and tools associated with these diseases. Infectious Disease Epidemiology (3) Emphasizes the epidemiological and microbiological methods used to study infectious diseases including new, emerging, and re-emerging diseases. Include are the history, Page 7

19 epidemiologic concepts and tools needed to understand and investigate the maintenance, transmission, and effects of infectious disease in human populations. CPH 701 Current Issues in Public Health (1) This seminar course will introduce MS and PhD students to the critical role of public health in protecting, maintaining, and improving the health of the population. Specific emphasis will be directed to the Ten Essential Functions of Public Health through weekly lectures, readings, and writing assignments. All five core areas of public health will be introduced List of Electives CPH 631 CPH 636 BST 740 BST 763/ STA 665 BST 713/ STA 653 BST 764 Design and Analysis of Health Surveys (3) Design and analysis issues associated with well known national health surveys, including reliability and validity of measurements, instrument validation, sampling designs, weighting of responses, and multiple imputations. Students will learn how to use statistical software to analyze data from complex survey designs. Data Mining in Public Health (3) This course concerns statistical techniques for and practical issues associated with the exploration of large public health data sets, the development of models from such data sets, and the effective communication of one s findings. Spatial Statistics (3) This course covers the following topics: risks and rates, types of spatial data, visualizing spatial data, analysis of spatial point patterns, spatial clustering of health events based on case control studies, and based on regional counts, linking spatial exposure data to health events through regression modeling, Bayesian spatial analysis. Analysis of Categorical Data (3) Multinomial and product-multinomial models; large-sample theory of estimation and testing, Pearson chi-square and modified chi-square statistics, Pearson-Fisher Theorem, Wald Statistics and generalized least squares technique; applications to problems of symmetry, association and hypotheses of no interaction in multi-dimensional contingency tables. Clinical Trials (3) Design and analysis of Phase I-III clinical trials, interim monitoring of trials, sample size, power, crossover trials, bioequivalency, mixed models, and meta analysis. Applied Statistical Modeling for Medicine and Public Health (3) This course introduces some useful statistical models not typically encountered in the core courses of a master s or doctoral biostatistics curriculum. Page 8

20 These include finite mixture models, nonparametric regression models, covariance-based models, and stochastic models. BST 765 BST 766 BST 701 CPH 610 CPH 614 CPH 616 CPH 617 Missing Data Methodology for Public Health (3) This course surveys methods for analyzing data with missing observations. This includes methods for data missing completely at random including hot deck cold deck, mean substitution, and single imputation; methods for data missing at random including multiple imputation and weighted estimating equations and methods for data missing not at random including pattern mixture models, selection models, and shared random effects models. Analysis of Temporal Data in Public Health (3) This course surveys methods for analyzing public health data collected over time. Methods covered include smoothing time series data, the modeling of stationary time series for Gaussian, dichotomous, and case count responses, methods for detecting the clustering of disease over time, and methods for the surveillance of infectious diseases in real time. Bayesian Modeling in Biostatistics (3) This course provides an introduction to Bayesian ideas and data analysis applied to the biosciences. The course illustrates current approaches to Bayesian modeling and computation in biostatistics. Injury Epidemiology (3) Describes the distribution and determinants for traumatic injury and poisonings, including both intentional and unintentional events. Topics include: sources of data, methodological approaches to studying injuries, evaluation of injury interventions, and the link between epidemiology and public health policy impacting injuries. Managerial Epidemiology (3) Reviews the fundamental principles of epidemiology and teaches students how to apply these principles to the management of health service organizations. Cardiovascular Epidemiology (3) Provides students with an overview of the risk factors associated with cardiovascular disease. Also teaches students about variations in the frequency of risk factors and in the rates of cardiovascular disease by characteristics of person, time and place. Environmental and Occupational Epidemiology (3) Provides students with an understanding of occupational and environmental exposures and their associations with specific health effects, and with the application of epidemiologic concepts and methods to describe and analyze these associations. Combines lectures on exposure assessment, study design and methodological issues, as well as discussion and presentation of topics focused on specific outcomes and exposures. Page 9

21 CPH 662 CPH 718 CPH 718 CPH 718 Public Health Response to Terrorism & Disasters (3) Focuses on public health concepts, history, methods, planning and response preparedness in response to a Weapons of Mass Destruction (WMD) terrorist attack, in both the nation and Commonwealth of Kentucky. Will discuss how public health methods can be applied to response planning and preparedness for such a bioterroristic WMD attack and improve the public health and medical infrastructure for response to natural disasters. Public health response includes surveillance of disease and laboratory reports for evidence of WMD attack, as well as epidemiological review of suspicious cases of illness potentially related to biological or chemical weapons. Special Topics: Decision-Making in Health and Medicine (3) This course applies decision science theory to healthcare decision making. It is intended for epidemiologists, managers, and health behaviorists who want to understand the process of rational decision-making. Topics include (1) managing uncertainty, (2) treatment decisions, (3) valuing healthcare outcomes, (4) diagnostic test decisions, (5) prevention and screening, (6) tests with multiple outcomes, (7) cost-effectiveness, cost-benefit, and costutility analysis, and (8) modeling events that reoccur over time. Special Topics: Oral Health Epidemiology (3) This course describes the concepts and principles of oral health epidemiology. The purpose is to use epidemiology principles and concepts and apply them to oral health related questions. This is an advanced, 700 level course, and will be intense. Although basic and intermediate/ advanced principles of epidemiology, biostatistics and oral biology will be reviewed early in the course, students are expected to have good working knowledge of these subject areas. Students are not expected to have a background in dentistry, but their biology, math and critical thinking abilities are expected to be worthy of the level of this course. The course includes discussions of the theory and methods of epidemiology, biostatistics and biology, sociology and philosophy and their applications to oral health. Special Topics: Cancer Epidemiology (3) This course applies and integrates the principles and tools of epidemiology to the study of cancer. The course includes discussion of the burden of various kinds of cancer across the United States and the world by age, gender, and race/ethnicity, the underlying biology behind the development of cancer in humans, cancer surveillance, the epidemiology of various kinds of cancer by category of major risk factors such as human behavior (e.g. smoking and alcohol use), endogenous/exogenous hormones, viruses, environmental/ occupational, and diet, and sources of data and methods for evaluating cancer screening, measuring the impact of risk factors, determining the incidence of cancer and cancer clusters, measuring patterns of care, and understanding the determinants of survival. Page 10

22 CPH 718 Special Topics: Cancer Molecular Epidemiology (3) This course will consist of lectures relating to the principles of molecular epidemiology, cancer prevention, and control. Lectures include: Biomarker Discovery using proteomic techniques, Cancer Screening, Genomics and Pharmacogenomics, Cancer susceptibility: Single Nucleotide Polymorphisms and DNA Damage and DNA Mismatch Repair Genes, Cancer Risk Assessment, Cancer Diagnosis and Prognosis, Cancer Theragenosis, and Transitional Studies: Biospecimens and Bioinformatics. Evaluation of Program Main Goals of the Program: 1) Provide students with substantive methodological and quantitative preparation in the academic disciplines of biostatistics and epidemiology. 2) Provide advanced, research-oriented training in both theory and methodology in these disciplines. 3) Develop researchers who will be skilled in solving problems on the interface between biostatistics and epidemiology as they relate to designing and conducting studies as well as analyzing, and interpreting the results from increasing variety of designs and databases in the public health and medical research. List of Goals assessed at each of the program s milestones: Comprehensive exam: Goal 1 Qualifying Oral Exam: Goal 1 Goal 2 Dissertation Research: Goal 3 III. Resources The Departments of Epidemiology and Biostatistics at the University of Kentucky have sufficient resources to initiate and maintain the proposed Ph.D. program in Epidemiology and Biostatistics. Having recruited two new core faculty in 2006 (Drs. Browning and Chattopadhyay), the Department of Epidemiology now has six core faculty (the others are Drs. Caldwell, Fleming, Hopenhayn, and Tucker) and five adjunct faculty (Drs. Baron, Mannino, Coker, Steinke, McKnight, who will be active in the proposed Ph.D. program. In an ordinary academic year, the core and adjunct faculty in Page 11

23 the Department of Epidemiology can cover a maximum of approximately 18 courses. With the proposed Ph.D. program, the net increase in the number of courses for which the Department of Epidemiology will be responsible in an ordinary academic year is approximately 3, so that the total number of courses for which the Department of Epidemiology will be responsible in an ordinary academic year is approximately 15. Three of the six core faculty in the Department of Epidemiology are currently tenured, ensuring that dissertation advisory needs will be met on the Epidemiology side. As for the Department of Biostatistics, one new core faculty member was recruited in 2006 (Dr. Bush), one was recruited in 2007 (Dr. Wang), and one was recruited in 2008 (Dr. Fardo). The Department of Biostatistics thus has seven core faculty (the others are Drs. Branscum, Charnigo, Kryscio, and Mendiondo) and two adjunct faculty members (Drs. Shelton and Rayens) who will be active in the proposed Ph.D. program. In an ordinary academic year, the core and adjunct faculty in the Department of Biostatistics can cover a maximum of approximately 18 courses. With the proposed Ph.D. program, the net increase in the number of courses for which the Department of Biostatistics will be responsible in an ordinary academic year is approximately 7, so that the total number of courses for which the Department of Biostatistics will be responsible in an ordinary academic year is approximately 18. One of the seven core faculty in the Department of Biostatistics is currently tenured, but three of the others will be considered for (and hopefully granted) tenure by the time the students in the first cohort of the proposed Ph.D. program are ready to select dissertation advisors. Hence, dissertation advisory needs will be met on the Biostatistics side. IV: Academic Program Approval Checklist 01: Are more Kentuckians ready for postsecondary education? A. Entrance requirements: Bachelor s Degree, Introductory statistics (STA 580 or equivalent), an undergraduate course in Life Sciences, two semesters of calculus. B. Transfer requirements: N/A C. Recruitment Plans: The four target audiences for this program are (i) graduates from a master s in public health with concentrations in epidemiology or biostatistics, (ii) graduates from a master s degree program in epidemiology, biostatistics, the mathematical sciences, or applied statistics, (iii) master s level graduates from psychology, computer science, engineering, business, biology, or chemistry and (iv) people who have completed undergraduate degrees in the fields listed in (ii) and (iii). We will work with all regional universities in the state and surrounding states to ensure a smooth transition from M.S. level graduate programs or relevant undergraduate programs to our doctoral program. We will create flyers to post at these institutions as well as volunteer to visit these institutions to present seminars to highlight the research programs of the faculty in the program. We also plan to work with the AMSTEM program on campus to attract students from disadvantaged backgrounds into our program. 02: Are more students enrolling? Page 12

24 A. Program demand: This program is necessitated by national trends requiring qualified individuals to teach and provide consultative services in advanced epidemiology and biostatistics, especially as they apply to medical sciences and public health. The demand for such expertise is especially critical for the Commonwealth of Kentucky, which consistently ranks low in national standings for many adverse health events. In addition, graduates of this program will be able to conduct independent biomedical research in their specialization area. In the last twenty years, the demand for biostatisticians and epidemiologists has grown dramatically, as opportunities to participate in the design, conduct, and analysis of biomedical and public health research projects have continued to expand. A 2006 survey compiled by the Association of Schools of Public Health documented that 6.7% (1,892) of the students enrolled in the 38 accredited schools of public health were pursuing a degree in Biostatistics, while 19.4% were pursuing a degree in Epidemiology (5,478) ( Over 40% of these students were pursuing a PhD degree. Currently, no dual Biostatistics/ Epidemiology PhD programs exist in the Commonwealth and therefore we expect a strong demand for this program from among a broad array of in-state and national and international students who are quantitatively trained at the undergraduate level and who are interested in biostatistics and epidemiology. B. Detailed recruiting plans: see 01.C above C. Equity: In accordance with University of Kentucky policy, this program will provide opportunities to people regardless of economic or social status and will not discriminate on the basis of race, color, ethnic origin, national origin, creed, religion, political belief, sex, sexual orientation, marital status, age, veteran status, or physical or mental disability (University of Kentucky, Office of Institutional Equity and Equal Opportunity, 03: Are more students advancing through the system? A. Time to graduation: This program is designed to be completed within 4 years, however it may take some students longer. B. Reason for offering the program: The demand for epidemiologists and biostatisticians in biomedical research, animal health, pharmacology, genetics, and community-based research is well-documented. There has long been a shortage of well-trained biostatisticians to collaborate with scientists in academia, industry, and government. The shortage is expected to worsen as senior biostatisticians retire. (Yang, Song; Gangon, Ronald E; Sullivan, Lisa M; Weems, Kimberly S, Summer Institutes for Training in Biostatistics (SIBS): Addressing the Biostatistician Shortage. JSM 2007 Proceedings.) This program offers a unique compilation of courses that incorporate epidemiological and biostatistical theory and application. Graduates will be prepared to actively participate in scientific research teams, assist in the writing and review of proposals, protocols, and manuscripts, design community-based and clinical trials, as well as develop methods for applied problems in Page 13

25 epidemiology and bisotatistics. Hence, by offering the program, the University of Kentucky will help to fill the ever-increasing need for epidemiologists and biostatisticians demanded by academia, industry, and government. C. Delivery. Some elective courses may be delivered through distance learning. D. Collaborative Efforts. The departments of Epidemiology and Biostatistics are collaborating together with the College of Public Health to develop this program. In addition, the Department of Biostatistics is collaborating with the Department of Statistics to cross-list BST 762/STA 607, STA 653/ BST 763, and (STA 665/CPH 637). 04. Are we preparing Kentuckians for life and work? A. Graduates from this program will be able to fill positions in academia, government, and industry at high levels of professional influence. The starting salaries for doctoral prepared biostatisticians currently range from about $87,000 in academic positions to $140,000 in industry settings. This range is very similar for epidemiologists. Graduates who have a strong skill set in research methods, study design, and advanced statistical analysis, with a substantive focus in areas of environmental, genetic, social, injury, or infectious disease disciplines, will be well suited for higher level research opportunities. Graduates of this program should command beginning salaries in this range. This program is congruent with efforts to advance the University of Kentucky to a top 20 research institution. B. Accreditation expectations: This combined PhD program in epidemiology and biostatistics will be subject to the accreditation requirements of the College of Public Health and the Graduate School at the University of Kentucky. The program will be reviewed for productivity, resource utilization, placement of the graduates, and comparability with (related) peer programs in the nation. C. This program will be accountable to the accreditation requirements of PhD programs in the Graduate School at the University of Kentucky. D. Expected degree productivity: It is expected that 3-5 students will initially be admitted to the program in its first year of initiation. These students are expected to complete the program of study in 4 years. After the initial 1-2 years of experience with the program, it is anticipated that, with recruitment, demand, and increasing resources in these two Departments (i.e. faculty lines), the program will admit approximately 10 students per year. 05. Are Kentucky s communities and economy benefiting? A. External Advisory Groups: The College of Public Health at the University of Kentucky has an external advisory group representing public health leaders throughout the state. The Advisory Committee and other external health care groups have consistently recognized the lack of individuals in Kentucky who are trained in both Epidemiology and Biostatistics. The proposed PhD program in both Epidemiology and Biostatistics directly addresses this need. B. Employment expectations: The demand for individuals with training in Epidemiology and Biostatistics at the doctoral level is intense. There is a Page 14

26 shortage of individuals with this specific training nationally and this shortage is particularly acute in Kentucky. Anyone completing the proposed degree will be highly sought after for their unique and important knowledge and skills. C. Other benefits. One of the most significant problems facing Kentucky communities is unhealthy populations. These problems have been well documented. People living in Kentucky have higher rates of cancer (specifically lung cancer, colon cancer, and cancer of the uterine cervix). The Kentucky population has higher rates of obesity, heart disease, and diabetes. These health problems have devastating impact on the workforce and economy of Kentucky communities. The graduates from this program will have unique skills that will help them measure the effectiveness of no health intervention programs, including educations, screening, and treatment. Until individuals with the specific education outlined in this proposal are available, Kentucky communities will continue to suffer from health problems that can be prevented or controlled through more effective education, screening and treatment programs. D. Specific benefits. See above. Page 15

27 New Course Proposals

28 New Course List BST 639 Computing Tools (cross-listed as CPH 639) BST 675 Biometrics I BST 676 Biometrics II BST 701 Bayesian Modeling in Biostatistics BST 760 Advanced Regression BST 761 Time to Event Analysis BST 762 Longitudinal Data Analysis (cross-listed as STA 632) BST 764 Applied Statistical Modeling for Medicine and Public Health BST 765 Missing Data Methodology for Public Health BST 766 Analysis of Temporal Data in Public Health EPI 714 Epidemiologic Study Design EPI 715 Research Methods in Epidemiology and Biostatistics EPI 716 Infectious Disease Epidemiology

29 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 639 b. Title * Computing Tools for the Biomedical Sciences * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Computing Tools c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( 2 ) LABORATORY ( 2 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course is an introduction to statistical and epidemiologic software technologies commonly used for the collection, management, and analysis of data. h. Prerequisite(s), if any: STA 580 or consent of instructor and basic computer literacy i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: CPH 639 Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / 2009

30 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics or Epidemiology Departments b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. It may be of interest to graduate students from other colleges and to the MPH and Dr.PH students in the College of Public Health. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

31 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Marta S. Mendiondo Phone: ext marta@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

32 BST/CPH 639: Computing Tools for the Biomedical Sciences Course Description: Introduction to statistical and epidemiologic software technologies commonly used for the collection, management, and analysis of data. This is a core course for the PhD in Epidemiology and Biostatistics. It is designed to prepare first year students for further coursework and dissertation research. This course will also be offered to MPH and DrPH students in the College of Public Health (CPH) and will be open to graduate students in other colleges. The primary software packages used are SAS, R/S-Plus, STATA, SPSS and EpiInfo. Topics to be covered in each package include the structure of each language, basics of writing, opening and running an application, data manipulation (such as transforming variables and label/formatting variables), numerical data summaries, graphical data summaries, exploratory data analysis, elementary data mining, multivariate analysis, and introduction to various regression models including linear, logistic, Poisson, and Cox regression. Course Structure: 3 credit hours (2 hours lecture, 2 hours of laboratory) Prerequisites: Computer literacy and STA 580 or equivalent, or consent of instructor Initial offering: Fall 2009 Instructors: The course leader can be any faculty member in the Departments of Biostatistics or Epidemiology. This course may be taught by a team of two or more faculty from the Biostatistics and Epidemiology departments in the CPH. Philosophical Statement: Students with doctoral training in epidemiology and biostatistics who pursue careers in academia, business, industry, or government must be able to properly manage and analyze data. This course surveys commonly used software packages for the statistical analysis of data in the life sciences. Objectives: 1. Students will learn fundamentals including syntax, missing values, format, labeling 2. Students will learn introductory data management including creating and modifying variables, sorting, transformations, merging, linking, subsetting 3. Students will be able to produce basic statistics such as data summaries, correlation, chi squared, t tests, estimating epidemiologic risk, ANOVA, linear, logistic, Poisson, and Cox and accelerated failure time regression models 4. Students will learn how to implement nonparametric rank-based and permutation procedures, and elementary resampling methods 5. Students will learn how to produce publication quality graphics and tables 6. Students will learn elementary programming in each software package 7. Students will learn elementary programming simulation References: 1. Lecture notes provided by the instructors. 2. SAS Publishing (2001). Step-by-Step Programming with Base SAS Software. 3. Der, Geoff and Brian Everitt (2006). Statistical Analysis of Medical Data Using SAS.

33 4. Juul (2006). An Introduction to STATA for Health Researchers. 5. Rabe-Hesketh, S, Everitt, BS (2007). Handbook of Statistical Analysis Using STATA. 6. Long (2005). Regression Models for Categorical Dependent Variables Using Stata. 7. Krause and Olsen (2005). The Basics of S and S Plus. 8. Venables and Ripley (2001). Modern Applied Statistics with S Plus. 9. Everitt and Rabe-Hesketh (2001). Analyzing Medical Data using S Plus. 10. Abrahamson and Gahlinger (2001). Computer Programs for Epidemiologists: Pepi Version 4.0. Course Outline: Sections I-IV will be covered using the software packages SAS, R/S-Plus, STATA, SPSS, and Epi-Info. I: Fundamentals Language structure Writing and running files Formatting data, labeling data, handling missing data Simple numerical and graphical summary statistics Data manipulation and transformations II: Data Management Reading data from external files Outputting results to external files Creating new variables Defining continuous and categorical variables III: Data Analysis Numerical and graphical summaries T test, t-interval ANOVA Elementary categorical data analysis Regression linear, logistic, Poisson, Cox, AFT Nonparametric procedures Bootstrapping Simulation IV: Programming Writing independent functions For loops, do loops, if statements V: Epi-Info, PEPI Estimating and comparing epidemiologic risk, odds, rates, and survival Data manipulation Categorical Analysis Odds ratios, risk ratios, risk differences, ROC Curves

34 Logistic regression and survival analysis Analysis of complex survey data VI: Introduction to specialized software packages N-Query Advisor NCSS DBSM Copy STAT Transfer Assessment: Grades will be based on problem sets and lab assignments (40%), in-class exams (40%), and a final project (20%).

35 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 26, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 675 b. Title * Biometrics I * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 4 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 4 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course, the first of a two-semester sequence in biometrics, introduces probability, discrete random variables, continuous random variables, joint distributions, and sampling distributions. h. Prerequisite(s), if any: STA 580 (Introductory Statistical Methods) and CPH 608 (Public Health Capstone) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / 2009

36 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course will be a requirement in the proposed Ph.D. Epidemiology/Biostatistics programs. This course will also be available as a selective for M.P.H. and Dr.P.H. students concentrating in Biostatistics who have the prerequisite noted above. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per year 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course: In order to change the program(s), a program change form(s) must also be submitted.

37 APPLICATION FOR NEW COURSE 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

38 BST 675: Biometrics I Course Description: This course, the first of a two-semester sequence in biometrics, introduces probability, discrete random variables, continuous random variables, sampling distributions, and some useful inferential techniques. Course Structure: 4 credit hours (4 hours of lecture, 0 hours of laboratory) Prerequisite: STA 580 (Biostatistics I) or equivalent introductory course in statistical methods, plus two semesters of calculus Initial Offering: Fall 2009 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: Students pursuing a doctoral degree in epidemiology and/or biostatistics must be prepared to deal with issues in the collection, analysis, interpretation, and presentation of numerical data. Probability serves as the foundation for strategies in prediction and inference. This course is designed to enable students to obtain an in-depth understanding of the principles of probability so that these students can apply these principles in the practice of biostatistics. The course will emphasize probability principles as they relate to biostatistical methods and to applications in public health and allied fields; however, the course will be conducted with enough mathematical rigor to avoid repeatedly asking students to take on faith results that should be understood in some depth. A special feature of the course will be the motivating case studies incorporated into the various units. Each case study will either: demonstrate the application of probability theory in public health, pharmaceutical science, or medicine; or, illuminate the rationale for a commonly employed biostatistical method. Objectives: Students completing BST 675 will be able to: 1. Use conditional and unconditional probability to solve biostatistical problems. 2. Formulate probabilistic models for random phenomena in public health and allied fields. 3. Describe the properties of a random sample. 4. Articulate connections between probabilistic principles and biostatistical methods. Textbook: Larsen and Marx (2005). Introduction to Mathematical Statistics and Its Applications. Prentice Hall. Detailed Outline: I. Probability a. Motivating case study #1: For which diseases are diagnostic tests useful? b. Motivating case study #2: Infant mortality and Simpson s paradox c. Definition and axioms of probability d. Conditional probability and Bayes Theorem e. Independence f. Counting g. Resolution of motivating case studies II. Discrete Random Variables a. Motivating case study #1: Assessing the potential of a new pharmaceutical b. Motivating case study #2: Evaluating the adequacy of hospital resources c. Motivating case study #3: Is leukemia contagious?

39 d. Probability mass functions and cumulative distribution functions e. Expected values, means, and variances f. Binomial family g. Poisson family h. Geometric and Negative Binomial families i. Resolution of motivating case studies III. Continuous Random Variables a. Motivating case study #1: Describing a distribution of birthweights b. Motivating case study #2: Modeling a distribution of times to smoking recidivism c. Probability density functions and hazard functions d. Expected values, means, and variances e. Normal family f. Exponential and Gamma families g. Resolution of motivating case studies IV. Sampling Distributions a. Motivating case study #1: Do we use a Z statistic or a T statistic? b. Motivating case study #2: How large is a large sample? c. Random samples and linear combinations d. The T pivot for a normal population e. Convergence in distribution and the Central Limit Theorem f. Resolution of motivating case studies V. Some Techniques for Point Estimation a. Motivating case study #1: What sample sizes are needed to estimate immunization rates? b. Motivating case study #2: Obtaining degrees of freedom for a two-sample T test c. Method of moments d. Maximum likelihood e. Resolution of motivating case studies VI. Some Techniques for Hypothesis Testing a. Motivating case study #1: Testing whether a drug relieves pain in a very small sample b. Motivating case study #2: Testing for increases in blood lead levels without normality c. Exact tests d. Likelihood ratio tests e. Resolution of motivating case studies Assessment: There will be regular homework assignments (40%), a midterm examination (30%), and a final examination (30%). Note: Motivating case studies may vary from year to year.

40 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 26, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 676 b. Title * Biometrics II * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 4 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 4 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course, the second of a two-semester sequence in biometrics, introduces techniques for constructing and evaluating point estimators, hypothesis testing procedures, and interval estimators. h. Prerequisite(s), if any: required: CPH 675 (Biometrics I) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / 2010

41 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course will be a requirement in the proposed Ph.D. Epidemiology/Biostatistics programs. This course will also be available as a selective for M.P.H. and Dr.P.H. students concentrating in Biostatistics who have the prerequisite noted above. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per year 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course: In order to change the program(s), a program change form(s) must also be submitted.

42 APPLICATION FOR NEW COURSE 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

43 BST 676: Biometrics II Course Description: This course, the second of a two-semester sequence in biometrics, develops numerous techniques for constructing and rigorously evaluating point estimators, hypothesis testing procedures, and interval estimators. Course Structure: 4 credit hours (4 hours of lecture, 0 hours of laboratory) Prerequisite: BST 675 (Biometrics I) Initial Offering: Spring 2010 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: Students pursuing a doctoral degree in epidemiology and/or biostatistics must be prepared to deal with issues in the collection, analysis, interpretation, and presentation of numerical data. This course is designed to provide students with an introduction to the fundamental theories that form the basis of the inferential statistical procedures that they will utilize in the study and practice of biostatistics. The course will emphasize inferential principles as they relate to biostatistical methods and to applications in public health and allied fields; however, the course will be conducted with enough mathematical rigor to avoid repeatedly asking students to take on faith results that should be understood in some depth. A special feature of the course will be the motivating case studies incorporated into the various units. Each case study will: demonstrate the application of inferential theory in public health, pharmaceutical science, or medicine; or, illuminate the rationale for a commonly employed biostatistical method. Objectives: Students completing BST 676 will be able to: 1. Implement various point estimation, hypothesis testing, and interval estimation techniques when numerical data are supplied. 2. Understand the properties of point and interval estimators as well as approaches for comparing and evaluating them. 3. Understand the properties of hypothesis testing procedures as well as approaches for comparing and evaluating them. 4. Articulate connections between inferential principles and biostatistical methods. Textbook: Larsen and Marx (2005). Introduction to Mathematical Statistics and Its Applications. Prentice Hall. Detailed Outline: I. A Few More Useful Probabilistic Tools a. Motivating case study #1: Modeling a distribution of blood pressure and cholesterol scores b. Motivating case study #2: Finding an appropriate nonlinear transformation in regression c. Joint and marginal probability mass/density functions d. Univariate and bivariate transformations e. Convergence in probability and Slutsky s Theorem f. Resolution of motivating case studies II. More Techniques for Point Estimation a. Motivating case study: Should cancer rate estimates be zero when there are no cases? b. Bayesian posterior mode c. Bayesian posterior mean

44 d. Resolution of motivating case study III. More Techniques for Hypothesis Testing a. Motivating case study: Why three tests for the global null in PROC LOGISTIC? b. Wald tests c. Score tests d. Rank-based tests e. Resolution of motivating case study IV. Techniques for Interval Estimation a. Motivating case study #1: Can an interval for a cancer rate contain a negative number? b. Motivating case study #2: Constructing intervals from non-normal point estimators c. Inverting tests d. Pivoting e. Resolution of motivating case studies V. Evaluating Point Estimators a. Motivating case study #1: What if the sample variance entailed division by n? b. Motivating case study #2: Sample median and sample mean as competing estimators c. Unbiased estimators d. Mean square error e. Consistency f. Resolution of motivating case studies VI. Evaluating Hypothesis Tests a. Motivating case study #1: Why require such huge sample sizes in clinical trials? b. Motivating case study #2: Can a clinical trial have a positive result but not be definitive? c. Power calculations d. Unbiased, uniformly most powerful, and consistent tests e. Comparing nominal and actual significance levels f. Resolution of motivating case studies VII. Evaluating Interval Estimators a. Motivating case study #1: When should one-sided intervals be used? b. Motivating case study #2: How approximate is an approximate 95% interval? c. Controlling the length of an interval d. Unbiased and uniformly most accurate intervals e. Comparing nominal and actual confidence levels f. Resolution of motivating case studies Assessment: There will be regular homework assignments (40%), a midterm examination (30%), and a final examination (30%). Note: Motivating case studies may vary from year to year.

45 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 701 b. Title * Bayesian Modeling in Biostatistics * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Bayesian Biostatistics c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( 1 ) LABORATORY ( 2. ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: TThis course provides an introduction to Bayesian ideas and data analysis applied to the biosciences. The course illustrates current approaches to Bayesian modeling and computation in biostatistics. h. Prerequisite(s), if any: required: BST 760 (Advanced Regression) and BST 676 (Biometrics II) or equivalent i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / 2011

46 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: This course will be offered once every three semesters. 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

47 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Adam Branscum Phone: marta@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

48 BST 701: Bayesian Modeling in Biostatistics Course Description: This course provides an introduction to Bayesian ideas and data analysis applied to the biosciences. The course illustrates current approaches to Bayesian modeling and computation in statistics. The course will cover the following topics: Bayesian philosophy, prior, posterior and predictive distributions and inference, one and two population models based on normal, binomial, Poisson, and survival distributions, conjugate, informative, and reference prior distributions, linear and generalized linear models, survival analysis, ANOVA, missing data, diagnostics and model selection, aspects of modern Bayesian computational methods including Markov chain Monte Carlo methods (Gibbs sampler and Metropolis Hastings algorithm) and their implementation and monitoring, with applications to biomedical data analysis. Course Structure: 3 credit hours (2.5 hours of lecture, 1 hour of laboratory) Prerequisites: BST 760 (Advanced Regression) and BST 676 (Biometrics II) or equivalent. Initial Offering: Spring 2011 Philosophical Statement: Statistical models are developed for the purpose of addressing scientific questions. For each scientific question that is posed and for which data are collected, the truth is sought by developing statistical models that are useful in this regard. Bayesian statistics represents one of the major approaches to the whole of statistical modeling. Through hands-on experience with real data from a variety of applications, students will learn the basics of designing and carrying out Bayesian analysis, and interpreting and communicating the results. BST 701 will provide students an introduction to practical Bayesian methods for biostatistics data analysis, and illustrate the utility of the Bayesian philosophy in public health. While aimed at biomedical scientists, the methods presented apply to all disciplines in which data are collected to address scientific hypotheses. BST 701 has methodological, computational, and data analysis components. Although statistical methodology will be presented to the extent needed for students to understand the models and methods, the course emphasizes practical applications over theory. Objectives: On successful completion of the course, students will be able to 1. understand the Bayesian approach to statistical data analysis and how it compares to other modes of statistical inference 2. design, develop and implement Bayesian methods to address biomedical hypotheses 3. incorporate prior information into statistical inferences 4. make posterior inferences on parameters of scientific interest 5. conduct Bayesian analyses of complex biostatistics data sets 6. create WinBUGS programs to fit Bayesian models 7. interpret and communicate results from Bayesian data analysis

49 References: Lecture notes will be provided by the instructor. One of the following may be used as the official textbook: 1. Gelman, A, Carlin, J, Stern, H, Rubin, D (2004). Bayesian Data Analysis. Chapman & Hall. 2. Carlin, B, Louis, T (2000). Bayes and Empirical Bayes Methods for Data Analysis. Chapman & Hall. Detailed Outline: I. Fundamentals of Bayesian Biostatistics Why Bayesian statistics? Approaches to statistical inference and an overview of Bayesian ideas Probability review Prior distributions Likelihood Bayesian inference: point and interval estimation, hypothesis testing, prediction Single parameter models: binomial data, Poisson data, normal data Two sample problems Comparing means, proportions, rates, median survival times Effect measures: relative means, mean difference, odds ratio, risk ratio, risk difference, rate ratios, and median time to event, survival probabilities Multivariate normal models, Wishart distribution and Jeffreys prior Introduction to the WinBUGS software II. Bayesian Computation Monte Carlo integration, Law of Large Numbers, asymptotic approximations Markov chain Monte Carlo (MCMC) algorithms: Gibbs sampling, Metropolis-Hastings Adaptive rejection sampling Slice sampling WinBUGS for Gibbs sampling Convergence monitoring and diagnosis: multiple starting values, Gelman- Rubin diagnostic, autocorrelation function, thinning, initial values Inference from MCMC: method of composition, credible intervals, HPD intervals, posterior density estimation, posterior errors. III. Bayesian Regression Likelihood construction Normal regression: Bayesian linear model Bayesian ANOVA and MANOVA Bayesian Generalized Linear Models Logistic regression Poisson regression

50 Negative binomial regression Bayesian residuals Survival Analysis Cox proportional hazards models Accelerated failure time models Prior distributions: Data augmentation priors and conditional means priors WinBUGS implementations IV. Model Selection Bayes information criterion (BIC) Deviance information criterion (DIC) Bayes factors Savage-Dickey ratio Pseudo marginal likelihoods and Bayes factors Bayesian model averaging Reversible jump MCMC Predictive model selection Assessment: Grades will be based on problem sets and lab assignments (50%), a final examination (25%) and class project (25%).

51 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 760 b. Title * Advanced Regression * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course provides an introduction to theoretical methods and applications of linear and generalized linear models. Regression methods for normally distributed outcomes will provide a discussion of experimental design, design matrices, and modes of parametric inference for the linear model. Students will learn to apply these concepts in sophisticated data analysis where they will implement tools for model building and selection, variable selection, and handling categorical predictors, confounders and interactions. Additionally, students will learn polynomial regression and flexible alternatives such as weighted least squares and robust, ridge and nonparametric regression. Regression methods for non-normal outcomes (focusing on binomial and count data) will be covered in detail, providing students with foundational tools for understanding and implementing generalized linear models that are commonly used to analyze epidemiologic and public health data from various study designs including but not limited to cohort, case-control, and clinical trials. h. Prerequisite(s), if any: BST 675 (Biometrics I) and STA 580 (or equivalent) Co-requisite: BST 676 (Biometrics II) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both

52 APPLICATION FOR NEW COURSE 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. It may be of interest to graduate students from other colleges and to the MPH and Dr.PH students in the College of Public Health. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics

53 APPLICATION FOR NEW COURSE 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course: In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

54 BST 760: Advanced Regression Analysis Course Description: This course provides an introduction to theoretical methods and applications of linear and generalized linear models. Regression methods for normally distributed outcomes will provide a discussion of experimental design, design matrices, and modes of parametric inference for the linear model. Students will learn to apply these concepts in sophisticated data analysis where they will implement tools for model building and selection, variable selection, and handling categorical predictors, confounders and interactions. Additionally, students will learn polynomial regression and flexible alternatives such as weighted least squares and robust, ridge and nonparametric regression. Regression methods for non-normal outcomes (focusing on binomial and count data) will be covered in detail, providing students with foundational tools for understanding and implementing generalized linear models that are commonly used to analyze epidemiologic and public health data from various study designs including but not limited to cohort, case-control, and clinical trials. Course Structure: 3 credit hours (2 hours of lecture, 2 hours of laboratory) Prerequisites: BST 675 (Biometrics I) and STA 580 (or equivalent) Co-requisite: BST 676 (Biometrics II) Initial Offering: Spring 2010 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: Linear and generalized linear models provide the foundation for regression modeling in epidemiologic and public health research to identify and characterize associations between health outcomes and health predictors. Identification of factors predictive of beneficial or adverse health conditions in a population is a core task in the biosciences, and the methodological, computational, and data analysis components of BST 760 will provide PhD students in biostatistics/epidemiology the fundamental tool for designing and analyzing population health studies. Objectives: Students completing BST 760 will be able to: Identify the appropriate applications of linear and generalized linear models; Describe the uses and limitations of linear and generalized linear models; Utilize linear and generalized linear models in data analysis, along with contrasts and multiple comparisons, under consideration of power and sample size issues; Employ model building and diagnostics tools and corrective procedures; Understand the methods used to deal with practical problems such as unbalanced data, missing values, co-linearity, correlated data, and departures from model assumptions; Use the statistical software packages SAS and R to correctly implement linear and generalized linear model analyses

55 Understand the theory behind inferential methods for linear and generalized linear models Provide clear and concise interpretations and presentations of the results from linear and generalized linear model analyses. References: McCullagh, P. and J.A. Nelder (1989). Generalized Linear Models, 2 nd edition. Chapman and Hall: London. Kutner MH, Nachtsheim CJ, Neter J, Li W (2005). Applied Linear Statistical Models, 5 th edition. McGraw-Hill/Irwin Collett D (2003). Modelling binary data, 2 nd edition. Chapman and Hall: London. Detailed Outline: 1. Experimental Design a. One-way ANOVA b. Two-way ANOVA c. Sample size and power calculations 2. Multiple Linear Regression a. Model Specification b. Overview of matrix arithmetic and operations c. Matrix Formulation and the Design Matrix d. Parametric Inference 3. Multiple Linear Regression: Model Building a. Confounding (ANCOVA) b. Variable Selection c. Interactions d. Types of Sums of Squares e. Polynomial Regression 4. Multiple Linear Regression: a. Diagnostics and Residuals b. Alternatives to MLR 5. Generalized Linear Models a. Link Functions b. Numerical procedures for model fitting c. Asymptotic MLE Theory d. Model selection and diagnostics 6. GLMs for Binary and Categorical Outcomes a. Measures of Association b. Binomial Regression c. Case-Control Studies and Conditional Logistic Regression

56 d. Polytomous Logistic Regression 7. GLMs for Count Outcomes a. Incidence Rates b. Poisson Regression c. Overdispersion and negative binomial regression d. Alternatives to Poisson Regression Assessment: There will be data analysis projects (60%) and regularly assigned homework (40%).

57 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 761 b. Title * Time to Event Analysis * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: Analysis of time to event data encountered in Public Health and Medicine. Survival distributions and hazard functions. Time to event analysis using Kaplan-Meier method and life-table method. Accelerated failure time model, logit model for discrete data, complimentary log-log model, and proportional hazards model. Tests for goodness-of-fit, graphical methods, and residual and influence statistics. Time-dependent covariates, non-proportional hazards, left truncation, and late entry into the risk set. Sample size and power, competing risks, and time to event analysis with missing data. h. Prerequisite(s), if any: STA 580 or equivalent i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department

58 APPLICATION FOR NEW COURSE 5. Requested effective date (term/year): Fall / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. It may be of interest to graduate students from other colleges and to the MPH and Dr.PH students in the College of Public Health. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

59 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Marta S. Mendiondo Phone: ext marta@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

60 BST 761: Time to Event Analysis Course Description: Analysis of time to event data encountered in Public Health and Medicine. Survival distributions and hazard functions. Time to event analysis using Kaplan-Meier method and life-table method. Accelerated failure time model, logit model for discrete data, complimentary log-log model, and proportional hazards model. Tests for goodness-of-fit, graphical methods, and residual and influence statistics. Timedependent covariates, non-proportional hazards, left truncation, and late entry into the risk set. Sample size and power, competing risks, and time to event analysis with missing data. Course structure: 3 credit hours (3 hours of lecture and 0 hours of laboratory) Prerequisite: STA 580 or equivalent Initial offering: Fall 2009 Instructors: Any faculty member in the Biostatistics Department Philosophical Statement: Students pursuing applied graduate degrees in Epidemiology and /or Biostatistics in the College of Public Health must be able to analyze time to event data since it is routinely encountered in biomedical research and risk analysis. This is a core course for the PhD in Epidemiology and Biostatistics. This course will also be offered to MPH and DrPH students in the College of Public Health and will be open to graduate students in other colleges. Emphasis is placed on the application of existing methodology. These applications will focus on coherent and succinct written interpretation of results encountered when analyzing data in Public Health. Students will become familiar with the basics of the underlying theory behind this methodology. Objectives: Students completing BST 761 will be able to: 1. identify and differentiate amongst methods used in analyzing time to event data in Public Health 2. understand the assumptions involved in applying different methods 3. assess assumption s violations 4. conduct time to event analyses of Public Health and medical data using SAS and STATA create analysis reports summarizing relevant results References: 1. Klein JP and Moeschberger ML. Survival Analysis: Techniques for Censored and Truncated Data Second Edition*. New York: Springer, Kleinbaum DG and Klein M. Survival Analysis: A Self-Learning Text Second Edition*. New York, NY: Springer, Allison PD. Survival Analysis Using the SAS System: A Practical Guide*. Cary, NC: SAS Institute Inc., Cleves MA, Gould WW, and Gutierrez RG. An Introduction to Survival Analysis Using Stata. College Station, TX: Stata Press, 2002.

61 5. Collett D. Modelling Survival Data in Medical Research. Boca Raton, FL: Chapman & Hall/CRC Press, Hosmer DW and Lemeshow S. Applied Survival Analysis: Regression Modeling of Time to Event Data. New York, NY: John Wiley & Sons, Lee ET. Statistical Models for Survival Data Analysis. New York, NY: John Wiley & Sons, Selvin, Steve. Survival Analysis for Epidemiologic and Medical Research (Practical Guides to Biostatistics and Epidemiology). Cambridge University Press, Shuster JJ. Practical Handbook of Sample Size Guidelines for Clinical Trials. Boca Raton, FL: CRC Press, * denotes possible course text Detailed outline: I. Introductory concepts a. Describing survival distributions b. Interpreting the hazard function c. Simple hazard functions d. Origin of time e. Censoring and Truncation II. Estimating and comparing survival curves a. Kaplan-Meier method b. Testing for differences in survivor functions c. Life table method d. Life tables for grouped data e. Testing for covariate effects f. Log survival and smoothed hazard plots III. Parametric regression models a. Accelerated failure time model b. Categorical regressor variables c. Hypothesis testing in a parametric model d. Goodness of fit tests with likelihood ratio statistics e. Graphical methods for evaluating a model fit f. Left censoring and interval censoring g. Piecewise exponential model IV. Proportional hazards model a. Tied data b. Time dependent covariates c. Cox model with non-proportional hazards d. Interaction with time e. Left truncation and late entry into the risk set f. Estimating survivor functions g. Residuals and influence statistics V. Competing risks

62 a. Type specific hazards b. Estimates and tests without covariates c. Covariate effects via Cox models d. Multiple event types VI. Discrete data a. Logit model b. Complimentary log-log model with continuous time processes VII. Sample size and power a. Sample size for comparing exponential survival b. Sample size for log rank test c. Sample size for comparing piecewise exponential survival VIII. Survival analysis in presence of missing data IX. Survival and Clustering Assessment: At least six problem sets will be assigned and graded (30%). There will be two exams: a midterm (30%) and final exam (30%) each with two components: an in class component and a take home component. Students will also give a presentation (10%). Students are expected to know enough SAS ( or other statistical software package) to complete the take home portion on their own.

63 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 762 b. Title * Longitudinal Data Analysis * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Longitudinal Data c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course presents statistical techniques for analyzing longitudinal studies and repeated measures experiments that occur frequently in public health, clinical trials, and outcomes research. This course will cover linear mixed models, generalized linear mixed models and an introduction to nonlinear models as they apply to the analysis of correlated data. h. Prerequisite(s), if any: BST 676(Biometrics II) and BST 760 (Advanced Regression) OR STA 532 and STA 603 i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: STA 632 Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / 2010

64 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics or Statistics Departments b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. It may be of interest to graduate students from other colleges and to the MPH and Dr.PH students in the College of Public Health. Also, it will be of interest to students pursuing an M.S. in Statistics. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

65 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

66 BST 762/ STA632: Longitudinal Data Analysis Course Description: This course presents statistical techniques for analyzing longitudinal studies and repeated measures experiments that occur frequently in public health, clinical trials, and outcomes research. This course will cover linear mixed models, generalized linear mixed models and an introduction to nonlinear models as they apply to the analysis of correlated data. Course Structure: 3 credit hours (3 hours of lecture, 0 hours of laboratory) Prerequisites: BST 676 (Biometrics II) and BST 760 (Advanced Regression) OR STA 532 and STA 603 Initial Offering: Spring 2010 Instructors: Any faculty member in the Department of Biostatistics or Statistics Philosophical Statement: Repeated measures experiments and the collection of longitudinal data occur frequently in clinical trials, public health research, and in marketing and business applications. The correlated nature of this data violates the independence assumption of most statistical tests. Advances have been made in statistical methodology and in the implementation of methods to correlated data. This course offers students an opportunity to put into practice methods for analyzing correlated interval level and categorical outcomes. Discussions of correlated data and the methodology of analysis will be motivated by case studies arising from health surveys, clinical trials, and longitudinal studies. Statistical software and statistical computations for implementing the methodology will be covered as well. Topics covered will provide students with the tools to implement analyses of longitudinal data and will provide a foundation for doctoral students as they pursue further coursework in advanced data analysis methods. Objectives: A student in this course will be introduced to appropriate statistical methods used in the analysis of longitudinal data and the analysis of repeated measures experiments for both interval level and categorical measurements. Specifically, the objectives of the course are as follows: Learn how to analyze designed experiments with repeated measures from three points of view: analysis of variance, multivariate analysis, and linear mixed models Learn how to analyze and design observational longitudinal studies with linear trends Learn how to analyze models with random coefficients and to model covariance structures Become familiar with theory underpinning the software used to fit mixed models to data in the Gaussian outcomes case Utilize statistical methodologies for longitudinal and repeated measures data including restricted maximum likelihood, generalized estimating equations, and weighted least squares Learn how to analyze mixed models with non-gaussian outcomes: binary, ordinal, and. Poisson response with random effects. Provide students with an introduction to nonlinear models as applicable to growth curve data, Zero-Inflated Poisson models, and pharmacokinetic models. References: 1. Davis (2002) Statistical Methods for the Analysis of Repeated Measurements. Springer. 2. Diggle, Liang, Zeger, and Heagerty (2002) Analysis of Longitudinal Data. Oxford.

67 3. Little, Milliken, Stroup, Wolfinger, and Schabenberger (2006) SAS for Mixed Models, SAS Institute. 4. Brown and Prescott (2006) Applied Mixed Models in Medicine. Wiley. 5. Hedeker and Gibbons (2006) Longitudinal Data Analysis Wiley. 6. Fitzmaurice, Laird, and Ware (2004) Applied Longitudinal Analysis. Wiley Detailed Outline: 1. Repeated Measures Introduction a. Univariate Methods b. Multivariate Approaches c. Repeated Measures ANOVA: single group case d. Repeated Measures ANOVA: multiple groups case 2. Linear Mixed Models: Gaussian Data a. Simple linear regression with random intercept b. Compound symmetry and intraclass correlation c. Simple linear regression with random slope and intercept d. Specification of the Linear Mixed Model for the linear regression cases e. Design of longitudinal Studies: sample size and power 3. Linear Mixed Models (LMM): General theory a. Matrix formulation b. Estimation in the LMM c. Two stage and weighted least squares d. Maximum Likelihood e. Restricted maximum likelihood f. Inference for fixed effects: Wald tests g. Inference for Variance components 4. Linear Mixed Models in Practice a. Robust estimation of errors in parameter estimates of fixed effects b. Approximate t statistics c. Covariance pattern models: (i) structured versus unstructured patterns (ii) autocorrelated errors d. Residual analysis / transformed residuals e. Prediction and shrinkage f. Software: Proc Mixed in SAS 5. Generalized linear models a. Exponential family b. Marginal models c. Generalized estimating Equations d. Weighted least squares 6. Linear Mixed Model: non Gaussian Case a. Binary outcomes b. Ordinal Outcomes c. Nominal Outcomes d. Count responses e. Software: Proc Glimmix in SAS 7. Cluster Randomized and Multi-center Trials

68 8. NonlinearMixed Models a. Specification of the Model b. Application: Growth Curves c. Application: Zero-Inflated and Hurdle Models d. Application: Pharmacokinetics e. Software; Proc Nlmixed in SAS

69 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: 16 January 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 764 b. Title * Applied Statistical Modeling for Medicine and Public Health * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Statistical Modeling c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course introduces some useful statistical models not typically encountered in the core courses of a master s or doctoral biostatistics curriculum. These include finite mixture models, nonparametric regression models, covariance-based models, and stochastic models. h. Prerequisite(s), if any: BST 675 (Biometrics II) and BST 760 (Advanced Regression) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department

70 APPLICATION FOR NEW COURSE 5. Requested effective date (term/year): Fall / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. We If NO, please explain: anticipate offering it perhaps every third semester (i.e., twice every three years). 8. Why is this course needed? This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. This course will also be available as a selective for M.P.H. and Dr.P.H. students concentrating in Biostatistics who have the prerequisite noted above. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per offering 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be an elective for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

71 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

72 BST 764: Applied Statistical Modeling for Medicine and Public Health Course Description: This course introduces some useful statistical models not typically encountered in the core courses of a master s or doctoral biostatistics curriculum. These include finite mixture models, nonparametric regression models, covariance-based models, and stochastic models. Course Structure: 3 credit hours (3 hours of lecture, 0 hours of laboratory) Prerequisites: BST 675 (Biometrics II) and BST 760 (Advanced Regression) Initial Offering: Fall 2010 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: While linear models, generalized linear models, and mixed models are the bread and butter statistical methods, many problems in medicine and public health can be better addressed through more specialized methods not typically encountered in the core courses of a master s or doctoral biostatistics curriculum. These methods include finite mixture models, nonparametric regression models, covariance-based models, and stochastic models. A special feature of this course will be the motivating case studies that will be incorporated into the various units. Each case study will illustrate how a problem in medicine or public health can be addressed through one of the specialized methods introduced in the course. Doctoral students may also find that the course provides ideas for dissertation topics. Objectives: Students completing BST 764 will be able to: 1. Apply finite mixture models to problems in medicine and public health. 2. Apply nonparametric regression models to problems in medicine and public health. 3. Apply covariance-based models to problems in medicine and public health. 4. Apply stochastic models to problems in medicine and public health. References: 1. McLachlan and Peel (2000). Finite Mixture Models. New York: Wiley. 2. Loader (1999). Local Regression and Likelihood. New York: Springer. 3. Hastie, Tibshirani, and Friedman (2001). The Elements of Statistical Learning. New York: Springer-Verlag. 4. Mueller (1996). Basic Principles of Structural Equation Modeling. New York: Springer-Verlag. 5. Taylor and Karlin (1998). An Introduction to Stochastic Modeling. San Diego: Academic Press. Detailed Outline: I. Finite Mixture Models a. Case study #1: Describing birthweight distribution and fetal-infant mortality b. Case study #2: Comparing microarray data for adenoma patients vs. healthy controls c. Hierarchical structure and identifiability d. Expectation-maximization algorithm e. Selecting the number of components f. Estimating within-component risk g. Resolution of motivating case studies

73 II. Nonparametric Regression Models a. Case study: Describing trends in SARS incidence b. Kernel smoothing c. Local regression d. Spline smoothing e. Resolution of motivating case study III. Covariance-Based Models a. Case study: Relating economic status and depression in rural women b. Path analysis c. Exploratory and confirmatory factor analysis d. Structural equation models e. Resolution of motivating case study IV. Stochastic Models a. Case study: Describing the cognitive function of Alzheimer s patients b. Discrete time Markov Chains c. Continuous time Markov Chains d. Brownian Motion e. Resolution of motivating case study Assessment: There will be regular homework assignments (60%) and a final project (40%). Note: Motivating case studies may vary from year to year.

74 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: January 15, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 765 b. Title * Missing Data Methodology for Public Health * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Missing Data c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course surveys methods for analyzing data with missing observations. This includes methods for data missing completely at random including hot deck cold deck, mean substitution, and single imputation; methods for data missing at random including multiple imputation and weighted estimating equations and methods for data missing not at random including pattern mixture models, selection models, and shared random effects models h. Prerequisite(s), if any: BST 676 (Biometrics II) and BST 762 (Longitudinal Data Analysis) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department

75 APPLICATION FOR NEW COURSE 5. Requested effective date (term/year): Fall / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. We If NO, please explain: anticipate offering it perhaps every third semester (i.e., twice every three years). 8. Why is this course needed? This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. This course will also be available as a selective for M.P.H. and Dr.P.H. students concentrating in Biostatistics who have the prerequisite noted above. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per offering 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be an elective for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

76 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

77 BST 765: Missing Data Methodology for Public Health Course Description: This course surveys methods for analyzing data with missing observations. This includes methods for data missing completely at random including hot deck cold deck, mean substitution, and single imputation; methods for data missing at random including multiple imputation and weighted estimating equations and methods for data missing not at random including pattern mixture models, selection models, and shared random effects models Course Structure: 3 credit hours (3 hours of lecture, 0 hours of laboratory) Prerequisites: BST 676 (Biometrics II) and BST 762 (Longitudinal Data Analysis) Initial Offering: Fall 2010 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: Missing data occurs frequently in survey sampling, in longitudinal studies, and in clinical trials. Missing observations are either missing completely at random (MCAR), missing at random (MAR), or missing not at random (MNAR) and different statistical methodology applies to each setting. In both the longitudinal setting and the clinical trial setting participant drop out often generates missing observations. Specialized methodology focuses on this important special case. In all cases examples of health surveys, clinical trials, or longitudinal studies with missing responses will be used to motivate the methodology covered. Statistical software for implementing the methodology will be covered as well. Doctoral students may also find that the course provides ideas for dissertation topics. Objectives: Students completing CPH 765 will be able to: 1. Apply simple imputation methods to missing data problems in public health. 2. Apply multiple imputation methods to missing data problems in public health. 3. Apply pattern mixture models to missing data problems in public health 4. Apply selection models to missing data problems in public health. References: 1. Madow, Olkin, Rubin (eds) (1983) Incomplete Data in Sample Surveys. Volume II: Theory and Annotated Bibliography. NewYork: Academic Press. 2. Dmitrienko, Molenberghs, Chuang-Stein, and Offen (2005) Analysis of Clinical Trial Data Using the SAS System. Chapter 5: Analysis of Incomplete Data. Cary, NC: SAS Publishing 3. Little and Rubin(2002) Statistical Analysis with Missing Data. New York: Wiley 4. Rubin (1987) Multiple Imputation for Nonresponse in Surveys. New York: Wiley. 5. Schafer (1997) Analysis of Incomplete Multivariate Data. London: Chapman & Hall. 6. Molenberghs and Kenward (2007) Missing Data in Clinical Studies. New York: Wiley. 7. Allison (2001) Missing Data Thousand Oaks, CA: Sage Detailed Outline: I. Introduction to Incomplete Data a. Missing Data Mechanisms: MCAR, MAR, and MNAR b. Informative and non-informative missing data c. Review of statistical estimations techniques:

78 (i) likelihood estimation (ii) least squares (iii) estimation equations d. motivating examples from sample surveys, clinical trials, and longitudinal studies II. Imputation methods for Data MCAR a. Complete cases method b. Available Case method c. Single Imputation Methods (i) Hot Deck and Cold Deck (ii) Unconditional means (iii) Conditional Means (iv) Last Observation Carried Forward III. Multiple Imputation Methods for Data MAR a. Conditional Means b. Propensity Scores c. Monte Carlo Markov Chain d. Inference based on multiple imputations IV. Methods for Data MNAR a. Pattern Mixture Models b. Selection Models c. Shared Parameter Models d. Sensitivity Analysis V. Missing Categorical Responses a. Weighted Least Squares b. Estimation-Maximization algorithm VI. Nonparametric Methods a. Inverse Probability Weighting b. Quasi-Likelihood functions c. Weighted Estimating Equations Assessment: There will be regular homework assignments (60%) and a final project (40%). Note: Motivating case studies may vary from year to year.

79 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: January 15, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 766 b. Title * Analysis of Temporal Data in Public Health * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Temporal Data Analysis c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course surveys methods for analyzing public health data collected over time. Methods covered include smoothing time series data, the modeling of stationary time series for Gaussian, dichotomous, and case count responses, methods for detecting the clustering of disease over time, and methods for the surveillance of infectious diseases in real time h. Prerequisite(s), if any: BST 675 (Biometrics II) and BST 760 (Advanced Regression) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department

80 APPLICATION FOR NEW COURSE 5. Requested effective date (term/year): Fall / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. We If NO, please explain: anticipate offering it perhaps every third semester (i.e., twice every three years). 8. Why is this course needed? This course will be an elective in the proposed Ph.D. Epidemiology/Biostatistics program. This course will also be available as a selective for M.P.H. and Dr.P.H. students concentrating in Biostatistics who have the prerequisite noted above. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per offering 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be an elective for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

81 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

82 BST 766: Analysis of Temporal Data in Public Health Course Description: This course surveys methods for analyzing public health data collected over time. Methods covered include smoothing time series data, the modeling of stationary time series for Gaussian, dichotomous, and case count responses, methods for detecting the clustering of disease over time, and methods for the surveillance of infectious diseases in real time Course Structure: 3 credit hours (3 hours of lecture, 0 hours of laboratory) Prerequisites: BST 676 (Biometrics II) and BST 760 (Advanced Regression) Initial Offering: Fall 2010 Instructors: Any faculty member in the Department of Biostatistics Philosophical Statement: Public health data is routinely collected serially over time. In some cases time series models are used to describe the dependence of the response on predictor variables including covariates and possibly previous values in the series. In other cases there is interest to know if disease cases are clustering in time and if so how to model this clustering. Since public health officials often monitor cases counts for various infectious diseases over time, there is interest in detecting as early as possible an outbreak of the disease that could threaten the populace at risk. For non-infectious diseases there is interest in forecasting the number of cases to be expected in the future for health planning purposes. Specialized methodology focuses on these important problems. In all cases examples of real time series from public health will be used to motivate the methodology covered. Statistical software for implementing the methodology will be covered as well. Doctoral students may also find that the course provides ideas for dissertation topics. Objectives: Students completing BST 766 will be able to: 1. Apply simple smoothing techniques to serially collected data in public health. 2. Apply simple time series models for Gaussian, dichotomous, and case count responses. 3. Apply standard statistical tests to detect clustering of diseases in time 4. Apply techniques for identifying disease outbreaks 5. Apply simple forecasting techniques for the expected number of cases of a noninfectious disease References: 1. Brookmeyer and Stroup (2004) Monitoring the Health of Populations. New York: Oxford University Press 2. Diggle (1990) Time Series: A Biomedical Introduction. New York: Oxford University Press 3. Chatfield (1984) The Analysis of Time Series: an Introduction. London: Chapman & Hall

83 4. Haegerty and Zeger (1998) Lorelogram: a regression approach to exploring dependence in longitudinal categorical responses. J.Am. Stat. Assoc. 93: Zeger (1988) Regression model for time series of counts Biometrika 75: Detailed Outline: 1. Descriptive methods a. Time trends b. Seasonality c. Moving averages d. Fourier transforms e. Smoothing techniques kernel estimators, splines, and wavelets 2. Stationary processes Gaussian case a. Correlograms b. ARMA (autoregressive moving average)models c. Model diagnostics 3. Stationary processes dichotomous outcomes a. Lorelograms b. Marginal models c. Conditional models d. Extensions to count data loglinear models e. Extensions to ordinal data 4. Disease clustering in Time a. Ederer-Myers statistic b. Scan Statistic c. Tango statistic d. Introduction to spatio-temporal analyses 5. Surveillance Data a. Sources for public health surveillance data b. Outbreak detection in infectious diseases c. Role of the incubation period d. Joint analysis of cohort and time series data e. Forecasting using back calculation method Assessment: There will be regular homework assignments (60%) and a final project (40%). Note: Motivating case studies may vary from year to year.

84 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: October 4, 2007 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number BST 740 b. Title * Spatial Statistics * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: Course will cover risks and rates, types of spatial data, visualizing spatial data, analysis of spatial point patterns, spatial clustering of health events based on case control studies, and based on regional counts, linking spatial exposure data to health events through regression modeling, Bayesian spatial analysis. h. Prerequisite(s), if any: BST 760 i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: STA Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / 2009

85 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This is an elective course in the proposed PhD in Epidemiology and Biostatistics. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 10 per offering 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

86 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard J. Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

87 BST 740: Spatial Statistics Course Description: This course covers the following topics: risks and rates, types of spatial data, visualizing spatial data, analysis of spatial point patterns, spatial clustering of health events based on case control studies, and based on regional counts, linking spatial exposure data to health events through regression modeling, Bayesian spatial analysis. Course Structure: 3 credit hours (3 hours of lecture, 0 hours of laboratory) Prerequisites: BST 760 or equivalent. Initial Offering: Spring 2009 Instructors: Any faculty member in the Biostatistics Department Philosophical Statement: Characterizing spatial distributions of disease events and exposures, and identifying factors predictive of where disease occurs is a core component to epidemiologic and public health practice and research. CPH 638 will provide students a framework for analyzing spatial disease data, and illustrate the utility of spatial methods in public health. While aimed at biomedical scientists and public health practitioners, the course is also suitable for students in other disciplines for which knowledge of statistical and epidemiologic concepts, models and methods in spatial analysis are important. CPH 638 has methodological, computational, and data analysis components. Although statistical methodology will be presented to the extent needed for students to understand the models and methods, the course emphasizes practical applications over theory. Objectives: On successful completion of the course, students will be able to describe, display, and analyze and interpret spatial data. Specifically, students will be able to: 1. Identify sources and defining features of common types of spatial data 2. Smooth (predict) spatial distributions of disease and exposures 3. Identify disease clustering 4. Apply regression models to spatially quantify disease-exposure associations 5. Identify risk factors for spatial occurrence of disease 6. Contribute to the design and execution of studies designed to address research questions in which spatial data are prominent 7. Critically evaluate publications in applied spatial statistics and/or epidemiology References: Lecture notes will be provided by the instructor. One of the following may be used as the official textbook: 1. Lawson, A. Statistical Methods in Spatial Epidemiology. Wiley, Waller LA, Gotway CA. Applied Spatial Statistics for Public Health Data. Wiley, Spatial and syndromic surveillance for public health. Editors: A.B Lawson and K Kleinman. Wiley, Disease mapping and risk assessment for public health. Editors A. B. Lawson, A Biggeri, D Bohning, E Lesaffre, J-F Viel, R Bertollini. Wiley, 1999.

88 5. Lawson, A, Williams, F.L.R. (2001). An introductory guide to disease mapping. Wiley. Detailed Outline: I. Review of concepts used in analyzing public health data a. Risks and rates b. Standardized rates c. Epidemiologic study designs d. Modeling counts and rates through regression analysis e. Challenges with observational data: bias, confounding, effect modification, and ecological fallacies II. Spatial data a. Geographical coordinates, projections, vectors, polygons b. Sources of spatial data c. Geographic information systems III. Visualizing spatial data a. Types of statistical maps b. Smoothing rates: nonparametric methods, empirical Bayes c. Modifying areal units IV. Analysis of spatial patterns a. Spatial point processes: stationarity, isotropy, Poisson point process b. Intensity functions c. K function d. Point process models: Poisson cluster, Cox, and contagion/inhibition V. Detecting spatial clustering using case-control studies a. Comparing point process summaries b. Scanning local rates c. Nearest neighbor statistics VI. Detecting spatial clustering using regional count data a. Global indexes of spatial autocorrelation b. Local indicators of spatial association c. Goodness of fit statistics d. Focused tests e. Spatial power including conditional power VIII. Linking spatial exposure data to health events a. Linear regression assuming independent spatial data b. Linear regression models for spatially autocorrelated data c. Spatial autoregressive models d. Generalized linear models for spatial data IX. Bayesian models a. Overview of Bayesian ideas and data analysis b. Hierarchical structure c. Estimation and inference d. Markov chain Monte Carlo (MCMC) methods e. Metropolis-Hastings cluster sampling

89 Assessment: Grades will be based on problem sets (25%), critical review and leading class discussions on sets of published papers that apply spatial methods in public health (10%), a midterm examination (25%), and a final examination (40%).

90 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: January 15, 2008 Department/Division proposing course: Epidemiology 2. Proposed designation and Bulletin description of this course: a. Prefix and Number EPI 714 b. Title * Epidemiologic Study Design * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM (2 ) DISCUSSION ( ) LABORATORY ( 1 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( X ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course provides students with advanced course material relevant to the planning and execution of epidemiologic studies of various designs. The course will consider study designs which employ routinely collected data on disease occurrence, such as would be undertaken in government agencies and health departments, and the classic etiologic study designs including the case-control, prospective cohort, retrospective cohort, nested case control, case-cohort, and casecrossover designs. The course will focus considerable attention on measurement methods and measurement error, borrowing examples from the subfields of epidemiology including occupational, cardiovascular, and social epidemiology. Given current interest on multilevel methods of analysis, the class will discuss approaches to the incorporation of designing multilevel studies. Finally, we will consider recent advances in experimental epidemiology with consideration of controlled community trials. h. Prerequisite(s), if any: Introduction to Epidemiology (CPH 605) or consent of instructor i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other :

91 APPLICATION FOR NEW COURSE 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is part of a series of advanced epidemiology and biostatistics courses being developed for the joint epidemiology/biostatistics PhD program in the College of Public Health. 9. a. By whom will the course be taught? Dr. Steven R. Browning, MSPH, PhD and faculty in epidemiology b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. Course will be of interest to students in public health, nursing, and medical fields who are pursuing research degrees. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO

92 APPLICATION FOR NEW COURSE If YES, please name: Joint PHD program in epidemiology and biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course: In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Steven R. Browning Phone: [email protected] 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

93 EPI 714 Epidemiologic Study Designs DRAFT Syllabus & Schedule University of Kentucky College of Public Health

94 University of Kentucky College of Public Health Course Syllabus Title: Epidemiologic Study Designs Course Number: EPI 714 Time: TBA Credit: 3 Semester Hours Class Location: TBA Faculty: Steven R. Browning, MSPH, Ph.D. College of Public Health / College of Medicine Phone: EXT srbrown@ .uky.edu Office Hours: TBA 1

95 Syllabus EPI 714 Page 2 Course Description: This course provides students with advanced course material relevant to the planning and execution of epidemiologic studies of various designs. The course will consider study designs which employ routinely collected data on disease occurrence, such as would be undertaken in government agencies and health departments, and the classic etiologic study designs including the case-control, prospective cohort, retrospective cohort, nested case control, case-cohort, and case-crossover designs. The course will focus considerable attention on measurement methods and measurement error, borrowing examples from the subfields of epidemiology including occupational, cardiovascular, and social epidemiology. Given current interest on multilevel methods of analysis, the class will discuss approaches to the incorporation of designing multilevel studies. Finally, we will consider recent advances in experimental epidemiology with consideration of controlled community trials. Prerequisites: Introduction to Epidemiology (CPH 605) or consent of instructor Credit: 3 semester hours. Course Objectives: After completion of this course in Epidemiologic Study Design, the student will be able to: 1. Differentiate between epidemiologic study designs, assess their relative strengths for addressing various research questions and for making causal inferences from these designs. 2. Understand the issues in the planning and implementation of various epidemiologic study designs and develop an appreciation for the hybrid study designs (e.g. case-cohort, nested case control, case-crossover) which are often employed in research. 3. Discuss conceptual approaches to considering induction periods and latent periods in the design of epidemiologic studies. 4. Appreciate the issues associated with sample size estimation in epidemiologic study design. 5. Develop the technical skills for assessing measurement error using various tools (i.e. questionnaires, environmental sampling instruments, clinical measurements). 6. Consider methods for improving the sensitivity of epidemiologic studies through the disaggregation of categories of exposure or disease entities. 7. Review and consider state-of-the-science methods for conducting controlled community trials. Course Structure: The course will consist of seminar/discussion classes, lectures, and self study. The course will be enhanced by an online component in Blackboard which will provide resources for accessing class materials including assignments and readings. Students will be required to complete a

96 Syllabus EPI 714 Page 3 series of problem sets, take a midterm and final exam, and develop a brief proposal of an epidemiologic study using a design considered in the course. Relationship to Public Health Degree Program Goal(s) and Objectives: This course relates directly to the accomplishment of the educational program goals for the joint epidemiology/biostatistics PhD in the College of Public Health.

97 Syllabus EPI 714 Page 4 Course Materials: A course packet, including the syllabus, will be distributed on the first day of class to all students who are officially enrolled in the course. The course packet will contain a topic schedule for the course and a listing of the reading assignments. Problem sets will be either handed out in class or posted on Blackboard. Additional course materials will be distributed as the class progresses. There is one required text for the class and several recommended texts (see below). The texts for the course may be purchased at the Medical Center bookstore or the Kennedy Bookstore (405 S. Limestone). Additional reading materials will either be on reserve in the College of Public Health student lounge or available through Blackboard.. Required Textbook: Kelsey, J.L., Thomson, W.D. and Evans, A.S. (1996). Methods in Observational Epidemiology. Oxford University Press, New York. Recommended (optional) Textbooks: Szklo. M and Nieto J. Epidemiology: Beyond the Basics (2003). Jones and Bartlett Publishing. Required Readings (other than text): Required readings from journal articles, manuscripts, and other documents are listed in the daily assignments. Most of the journal articles for readings will be on reserve in the Department of Epidemiology graduate student area (room 209). Some of these are available as electronic documents in Blackboard. In addition, we have highlighted (in the assignments) those readings for which articles are available electronically from the e-journals at the medical library ( Students are responsible for securing their own copies of the readings and reviewing the materials prior to the class.

98 Syllabus EPI 714 Page 5 Evaluation: Assignments and Tests Points Mid-term examination 200 Problem Sets (4) 100 points for each. 400 #1 Confounding in case control studies 100 #2 Assessing measurement error 100 #3 Sample size estimation in study design 100 #4 Improving sensitivity in study designs 100 Class reading discussion lead and brief paper 100 Final Exam 200 TOTAL 900 Letter grades for the course will be assigned on a percentage basis (as given below) for the student s total score as a percentage of the total number of points possible for the course. Grade % Points (3 credit) A ,000 B C D F < 60 <600

99 Syllabus EPI 714 Page 6 Midterm exam: There will be a take-home mid-term exam. The exam will emphasize material covered in the assigned readings, lectures, and assignments. The mid-term will cover material considered until TBA date. The midterm exam is expected to be the student s own work. Reading discussion and class participation. Students enrolled in the class are required to lead a discussion of the reading materials for a given class. This requires that he/she is well prepared in having read the assigned literature and has prepared a series of questions or other activities for generating a discussion on the reading materials. A short presentation of major issues, controversies, or the basics of the technique may be presented to the class. It s an opportunity to be creative. A schedule will be established at the beginning of the semester for students leading the discussion. Problem Sets: The problem sets are due on the dates indicated below. The assignments involve applied computations relevant to epidemiologic study design. The assignments must be completed and handed in on the due date. The assignments must be a student s own work (i.e. each student must turn in a completed assignment) but students are encouraged and allowed to work together in solving the problems and assisting each other with the exercises. Points will be deducted for problem sets which are submitted after the due date. Problem sets will be discussed in the class. Number Topic Due Date Set #1 #1 Confounding in case control studies TBA Set #2 #2 Assessing measurement error TBA Set #3 #3 Sample size estimation in study design TBA Set #4 #4 Improving sensitivity in study designs TBA Study proposal: This project should generally follow and use the format of the PHS 398 forms and include (at minimum) the following sections: Introduction, Specific Aims, Brief Literature Review, Study Design, Measures Used, Data Analysis, Strengths and Limitations, and References. The length of the final document should be pages and should include at least 15 references. Students are encouraged to research current funding opportunities for ideas on topics. (Details are posted on Blackboard site for the course).

100 Syllabus EPI 714 Page 7 Final exam: There will be a take-home final exam. The final exam will cover material in the assigned readings, lectures, and assignments for the entire course but emphasize the topics following the midterm exam. The test will be given to the class on or before December 4 and need to be submitted by December 11 at 5:00 pm. Guidelines for the Use of Blackboard as a Supplement to the Course: Blackboard 7 is comprehensive and flexible e-learning software platform that delivers a course management system for online learning at the University of Kentucky. The system can be accessed via the internet at the following website ( During the beginning weeks of the course, students can obtain a user name and password for accessing the course materials related to EPI 714. These materials include copies of the syllabus and assignments, access to electronic datasets, and other readings and course materials. In addition, Blackboard provides access to websites related to the content of the course. Since the class only meets once per week, the Blackboard environment will permit students to discuss problems and assignments with each other and will allow the instructor to make general announcements to the class through the announcements frame or the facility. It is recommended that you check in at Blackboard at least once early in the week prior to class for any announcements relevant to the upcoming class. This portion of the course is new and still under development. Your comments and insights related to the web-based adjunct to the class will be much appreciated during the semester.

101 Syllabus EPI 714 Page 8 Topic Outline: Class Month Date Topic Faculty Ecologic studies: Design of studies using routinely collected data. Sources of data ( focus on state ) Data linkage TBA Approaches to the analysis of mortality data: trends and issues with small numbers. Methods of Sampling: Part 1 Simple random sample Systematic sampling Stratified sampling TBA Cluster sampling / Multistage sampling TBA Methods of Sampling : Part 2 Applications with NHANES / BRFSS Sample weighting TBA Survey Research and cross-sectional studies Analysis of survey data Presentation of survey graphics TBA Case control studies Principles of case / control selection Matching Bias in case control studies TBA Exposure assessment I. Questionnaire development In-person and telephone surveys TBA Exposure assessment II. Measurement of occupational exposures Development of job exposure matrices Measurement of biologic markers Quality control issues : sample processing TBA

102 Syllabus EPI 714 Page Measurement Error Misclassification Correcting for measurement error Multiple measurements TBA Cohort Studies I. Planning and execution Comparison group selection Diagnostic criteria for outcome TBA Cohort Studies II. Nested case control Case cohort design Case cross-over design TBA Data management issues Study documentation Participation rates Missing values issues Statistical software TBA Community based participatory research Clinical studies Using the resources of the GCRC TBA Patient population issues TBA Molecular / genetic epidemiologic studies Applications of biologic markers Criteria for evaluating biologic markers Proposal preparation / IRB / Ethical issues 16 TBA The lecture schedule is subject to change depending on the schedules of faculty. Students will be given notice in the event that a change needs to be made to the schedule. TBA

103 Syllabus EPI 714 Page 10 Summary of Important Dates: Problem Set # 1 Problem Set # 2 Midterm exam due Problem Set # 3 Problem Set # 4. Study proposal Final exam. TBA TBA TBA TBA TBA TBA TBA

104 Syllabus EPI 714 Page 11 Policy on absences and late submittal of work: Students are expected to attend all classes but are not required to do so in order to pass the class. Although attendance is not required and does not serve as a criterion for a grade in the course, examinations may include materials not covered in the texts, readings, or problem sets. Additionally, a point assignment is given for class participation. Students are expected to take the examinations on the day scheduled in the syllabus. Students who cannot take the examination on the scheduled day must have an excused absence (illness of student or family member, death of family member, university sponsored trip, etc.) as defined in the Student Rights and Responsibilities handbook. Students should inform the faculty in advance of the examination if a problem exists with respect to taking the exam on the designated day. Students will be given the opportunity to make up missed work or exams in the event of excused absences. Students are entitled to excused absences for the purpose of observing their major religious holidays. It is expected that all work submitted for a grade in the course be the work of the individual student. Students are allowed and encouraged to collaborate on assigned problems and problem sets for the course but must submit their own work. Students are encouraged to review sections on plagiarism and on cheating in the Student Rights and Responsibilities handbook. Incomplete or I grades: It is at the discretion of the faculty member to assign an 'I' grade at the students request. The student and faculty should agree on (1) what is needed to complete the course requirements to be assigned a final letter grade, and (2) faculty and student should agree on the time frame to complete this work. Please be aware that the faculty ARE NOT REQUIRED to give the student the entire 12 month period to complete the work. In fact, for this course, it is assumed that any necessary extensions needed to complete the work will be short and essentially equivalent to the amount of time that the student could not work on the assignments due to illness, family emergency, or other circumstances. The faculty member would work with the student in developing a time frame which is appropriate for the situation and manageable for both the faculty and student schedules. This will be agreed to in writing by both the student and faculty. Students are strongly encouraged to complete all assignments in the given semester as the policy to assign an I is at the discretion of the faculty member and will only be applied when circumstances are warranted. Enabling Accommodations: If you have a documented disability that requires academic accommodations, please see me during scheduled office hours. In order to receive accommodations in this course, you must provide me with a letter of accommodation from the Disability Resource Center. If you have not already done so, please register with the Disability Resource Center for the coordination of campus disability services.

105 Syllabus EPI 714 Page 12 Key Periodicals and Journals: Consulting these journals will be helpful when searching for articles. Public Health Reports American Journal of Public Health American Journal of Epidemiology American Journal of Industrial Medicine New England Journal of Medicine Journal of the American Medical Association (JAMA) Morbidity and Mortality Weekly Reports (MMWR) Archives of Environmental Health Journal of Occupational Medicine Epidemiology Supplemental Textbooks with a biostatistics / data analysis orientation: Hatcher, L., & Stepanski, E.J. (1994). A step-by-step approach to using the SAS System for univariate and multivariate statistics. Cary, NC: The SAS Institute, Inc. Munro, B.H., & Page, E.B. (1997). Statistical methods for health care research (3rd Ed.). Philadelphia: J.B. Lippincott. Abramson, J.H. (1994). Making sense of data (2nd Ed.). New York: Oxford University Press. Jaeger, R.M. (1990). Statistics: A spectator sport (2nd Ed). Thousand Oaks, CA: Sage. Kanji, G. (1999). 100 statistical tests. Thousand Oaks, CA: Sage. Krishnamwity, G., Kasovia-Schmitt, P., & Ostroff, D. (1995). Statistics: An interactive text for the health and life sciences. Boston: Jones and Bartlett. Matthews, D.E., & Farewell, V.T. (1988). Using and understanding medical statistics (2nd Revised Ed.). New York: Karger. Pedhazur, E.J. (1982). Multiple regression in behavioral research (2nd Ed.). Fort Worth, TX: Holt, Rinehart, and Winston, Inc. Tabachnick, B. G., & Fidell, L.S. (1989). Using multivariate statistics (2nd Ed.). New York: Harper Collins. Vogt, W. P. (1999). Dictionary of statistics & methodology: A nontechnical guide for the social sciences (2nd Ed.). Thousand Oaks, CA: Sage. Wallgren, A., Wallgren, B., Person, R., Jorner, U., & Haaland, J. (1996). Graphing statistics & data. Thousand Oaks, CA: Sage.

106 Syllabus EPI 714 Page 13 Wassertheil-Smoller, S. (1995). Biostatistics and epidemiology: A primer for health professionals (2nd Ed.). New York: Springer-Verlag. Wright, D. (1996). Understanding statistics: An introduction for the social sciences. Thousand Oaks, CA: Sage. Supplemental Textbooks with an epidemiology orientation: Principles of Epidemiology: An Introduction to Applied Epidemiology and Biostatistics. 2nd Edition (1992). US Department of Health and Human Services, Centers for Disease Control and Prevention. Hennekens, Charles H and Buring, Julie E. (1987) Epidemiology in Medicine. Little Brown and Company. Boston. Streiner, David L. & Norman, Geoffrey R. PDQ Epidemiodogy (2nd Edition). Mosby Publishers. Rose, Geoffrey (1992). The Strategy of Preventive Medicine. New York. Oxford University Press. Lilienfeld, David E. and Stolley, Paul D. (1994). Foundations of Epidemiology. 3rd Edition. Oxford University Press. Last, John M. (1995). A Dictionary of Epidemiology. 3rd Edition. New York. Oxford University Press. Mausner, J.K. and Kramer S. (1985). Mausner & Bahn: Epidemiology An Introductory Text. 2nd Edition. WB Sanders Co., Philadelphia. Kelsey, J.L., Thomson, W.D. and Evans, A.S. (1996). Methods in Observational Epidemiology. Oxford University Press, New York. [Extremely useful explanations of issues involved in casecontrol, retrospective, and prospective studies. A good discussion of matching, stratification, and design issues.] Abramson, J.H. (1988). Making Sense of Data: A Self-Instruction Manual on the Interpretation of Epidemiological Data. Oxford University Press, New York. Fletcher, R.H., Fletcher, S.W., Wagner, E.H. (1988). Clinical Epidemiology: The Essentials. 2nd Edition. Williams and Wilkins, Baltimore. Fleiss, J.L. (1982). Statistical Methods for Rates and Proportions, 2nd Edition. New York: John Wiley and Sons. [An excellent second-level statistics text concerned with the analysis of categorical data.] Rothman, K.J. (1986). Modern Epidemiology. Boston: Little, Brown. [An advanced text that covers both design and statistical issues. The focus is on observational epidemioloic studies and is directed more toward the researcher than the clinician.]

107 Syllabus EPI 714 Page 14 Kleinbaum, D.G., Kupper, L.L. and Morgenstern, H. (1982). Epidemiologic Research: Principles and Quantitative Methods. Belmont, CA. Wadsworth. [An advanced text primarily for those conducting observational epidemiologic research.]

108 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 10, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number EPI 715 b. Title * Research Methods in Epidemiology and Biostatistics * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: Research Methods c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( 3 ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course builds a broad array of skills that are useful for the design and development of research protocols and funding applications for peer review, and for the analysis of resultant scientific data. h. Prerequisite(s), if any: BST 760 (Advanced Regression), EPI 714 (Epidemiologic Study Design), and BST 639 (Computing Tools) i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / 2010

109 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course is a requirement in the proposed PhD in Epidemiology/Biostatistics. 9. a. By whom will the course be taught? This course will be team taught by faculty member in the Biostatistics or Epidemiology Departments b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics, which spans two departments.. It may also be of interest to graduate students from other colleges and to the MPH and Dr.PH students in the College of Public Health. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

110 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

111 EPI 715: Research Methods in Epidemiology and Biostatistics Course Description: In this course students will develop broad skills that are useful for the design and development of research protocols and funding applications for peer review, and for the analysis of resultant scientific data. Topics include, but are not restricted to: methods of evaluating research proposals; mechanisms of funding; specifying human subjects considerations; developing a set of research questions; designing a study to address these questions; consideration of sampling, study population, data collection methods, data management and appropriate data analysis techniques; writing a research proposal for a study; developing an appropriate budget and budget justification; writing a human subjects proposal where appropriate; developing a realistic timeline for the study; writing critiques of proposals. Course Structure: 3 credit hours (3 hours of lecture). Prerequisites: BST 760 (Advanced Regression), EPI 714 (Epidemiologic Study Design), and BST 639 (Computing Tools) or equivalent. Initial Offering: Spring 2010 Instructors: The course leader can be any faculty member in the Departments of Biostatistics or Epidemiology. This course will be taught by a team of two or more faculty from the graduate group in Epidemiology and Biostatistics. Philosophical Statement: Students with doctoral training in biostatistics and epidemiology who pursue careers in academia, business, industry, or government must be able to develop, implement, and carry out to completion a research protocol designed to address scientific questions in the biosciences. This includes identifying a research project, generating statistically testable hypotheses, designing an appropriate study, data collection and management, and conducting and/or supervising an appropriate statistical analysis. Objectives: On successful completion of the course, students will be able to 1. develop and write a statistically testable hypothesis from a biologic question and under various epidemiologic study designs 2. understand and utilize the theory and practice of designing experimental and observational studies in epidemiologic and biostatistics research to address biomedical hypotheses 3. understand the purposes of randomization and masking, and the selection of study participants to achieve comparability of study groups and to avoid selection bias 4. perform sample size and power calculations to achieve adequate statistical power

112 5. Evaluate data integrity and sampling methods for data collection to avoid recall and interviewer biases, design and analytic approaches to avoid confounding bias, and to evaluate data for confounding and effect modification 6. Apply theory and concepts of biostatistics and epidemiology to analysis and interpretation of common types of data generated in epidemiologic and biostatistics research 7. Evaluate, recommend, and interpret results from appropriate modeling approaches and statistical methods for complex epidemiologic data 8. Communicate study design and details, results of a data analysis, and interpretation of findings using a format suitable for scientific publication or presentation at a professional conference 9. identify and discuss strengths and limitations of research studies 10. understand how to write and review research proposals References: Lecture notes will be provided by the instructors. Detailed Outline: I. Research Plan 1: Overview Sources of funding Methods of review Selection of topics and hypothesis Statement of objectives and specific aims, background and significance Summarize literature and results from preliminary studies II. Research Plan 2: Epidemiologic study design Overview of epidemiologic study designs: the randomized trial, and observational case-control and prospective designs Strengths and limitations of study design, potential for bias. Measurement: assessment of exposure and disease in cohort and case-control studies Comparability: confounding and causal inference. III. Research Plan 3: Sampling and selection Sampling and selection of subjects Human subjects Achieving comparability in cohort and case-control studies matching, stratification, adjustment Choice of index groups (exposed or case) in cohort and case-control studies Choice of comparison groups (unexposed or control) in cohort and case-control studies Follow-up in randomized clinical trials and cohort studies Increasing participation, reducing attrition

113 Methods of data collection and management Biologic sampling Strengths and limitations of data, collection methods, potential for bias IV. Research Plan 4: Data analysis Sample size and power directed to specific aims in clinical trials, cohort, and case-controls studies Issues in the analysis of epidemiologic data from cohort and case-control studies: confounding and interaction Data description: data integrity, procedures for examining data, detecting and considering outliers, recoding, missing data, data presentation and graphics Univariate analysis and initial data exploration Bivariate and multivariate analysis Selecting a statistical modeling approach for the hypothesis: distributions of variables, appropriate transformations Variable selection and modeling steps: stepwise vs. thought-wise. Inclusion of confounders and effect modifiers Deriving causal inferences Describing study limitations V. Research Plan 5: Budget and budget justification Personnel - investigators, staff Equipment freezer, centrifuge, computer, supplies, assays, documents, copying, phones, faxes, stationery Travel subject, staff, investigator Subcontracts, consulting VI. Research Plan 6: Reviewing research proposals Strengths and limitations of design, subject recruitment and retention, methods of data collection and analysis, experience and capability of investigators, adequacy of budget and timeline, scoring system and funding VII. Research Plan 7: The end product Communicating of methods and results Writing proposals Reviewing proposals Assessment: Grades will be based on problem sets (40%), a written project proposal and presentation (40%), and a critical review of another student s project proposal (20%).

114 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: 6/12/08 Department/Division proposing course: Epidemiology 2. Proposed designation and Bulletin description of this course: a. Prefix and Number EPI 716 b. Title * Infectious Disease Epidemiology * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( X ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 3 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: g. Course description: This course provides instruction about the epidemiological and microbiological characteristics of bacteria, fungi, prions, rickettsia and viruses causing emerging and infectious diseases. h. Prerequisite(s), if any: Graduate student or consent of instructor i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Spring / 2009

115 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This is a required course in the new PhD program in Epidemiology and Biostatistics. 9. a. By whom will the course be taught? Any member of the Epidemiology Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. It will be of interest to Biostatistics students as well as Epidemiology students. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: PhD in Epidemiology and Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

116 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Glyn Caldwell Phone: [email protected] 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

117 EPI 716 INFECTIOUS DISEASES EPIDEMIOLOGY Spring 2009 Time: Monday 3:00 pm 5:30 pm Place: School of Nursing 214 Course Instructor: Glyn G. Caldwell, MD Office Hours Monday 1:00 pm to 2:45 pm in CPH 213 or by appointment COURSE DESCRIPTION This course will focus on the epidemiology, history, methods, and ancillary laboratory tools used in the study and control of infectious diseases and distinctive problems associated with each class of infectious agents. Discussions of theory and key concepts, epidemiological investigations and basic study designs will be included. The course will discuss how epidemiological methods can be applied to the study, investigation, prevention, and control of infectious diseases and emerging infectious diseases. COURSE GOAL The course goal is to produce an epidemiologist and pubic health practioner with the knowledge and skills to teach, investigate study, prevent, and control infectious and emerging diseases in both the academic and public health setting. COURSE OBJECTIVES This course will outline the history, epidemiological concepts, microbiological methods, and ancillary laboratory tools used in the study and control of infectious diseases in human populations. The course includes discussions of theory and methods, including key concepts of incidence, prevalence, mortality, transmission, reservoir, life cycle, prevention and control of infectious diseases. The course will define and outline the basic types of epidemiological investigations and distinctive features/problems associated with each. Students will, upon examination, be able to describe and discuss the following: I. Principles of Infectious Disease Epidemiology 1. Differentiate between a clinical and an epidemiological approach to the study and control of infectious diseases. 2. Describe the historical evolution of infectious diseases epidemiology. 3. Identify the contributions of microbiology and epidemiology as they relate to the prevention and control of infectious diseases. 4. Understand and be able to apply the correct methods to investigate a suspected infectious disease outbreak/epidemic.

118 5. Describe the concepts and interactions of agent, host, environment, vector, incubation time, transmission, life cycle (where appropriate) and reservoir. 6. Understand and be able to apply the concepts, methods, and appropriate study designs to the study of emerging infectious diseases and their potential etiologic agent(s). 7. Describe and understand the evolution and epidemiology of emerging and re-emerging infectious diseases. II. Principles of Infectious Disease Control and Prevention 1. Describe history of infectious diseases prevention and control. 2. Describe the diagnostic methods appropriate to infectious and emerging diseases. 3. Describe the various methods of prevention and control of communicable and emerging diseases. 4. Describe how physicians use epidemiological methods in their practice. RELATIONSHIP TO COLLEGE OF PUBLIC HEALTH TERMINAL OBJECTIVES This course relates directly to the accomplishment of the educational program goals for the joint PhD degree in Epidemiology and Biostatistics. The goals and objectives are described in the Student Handbook which students received upon enrollment into the program. Please reference the appropriate educational program goals throughout the semester, as they will provide a framework for this course and as such will contribute to your preparation for successfully completing other degree program requirements (e.g. comprehensive examination and dissertation). Relationship of This Course To the Epidemiology Concentration Area Terminal Objectives In relationship to the PhD degree, this course contributes toward fulfillment of the following terminal objectives for students in the combine epidemiology and biostatistics program. 1. Explain and apply the principles and methods of epidemiology as they apply to infectious and emerging diseases in a wide variety of clinical, community, environmental and public health situations. 2. Search, critically review, and synthesize and interpret the infectious and emerging diseases epidemiologic and public health and infectious disease literature to impact public health policy. 3. Identify and use appropriate epidemiologic and microbiological study designs for study of infectious and emerging diseases. 4. Collect and manage data for the investigation of infectious and emerging disease outbreaks. 5. Interpret and clearly communicate complicated epidemiological and infectious disease data and findings to collaborators, legislators, administrators, and the public to effect modification of public health

119 policy. 6. Effectively lead, educate, and mentor students, coalitions, clinicians, legislators, administrators, public health practioners, and other persons to utilize infectious and emerging disease data, methods, and finding to impact public health and public health practice. 7. Prepare and present a portion of an infection disease epidemiology course. COURSE REQUIREMENTS 1. Two examinations 25 percent (each examination) 2. Four brief papers 10 percent (each paper) 3. Prepare and present one lecture complete 10 percent with an outline, bibliography and an appropriate power point presentation 4. Each student is expected to prepare an outline and a bibliography of each assigned infectious disease epidemiology topic (10 percent of grade for each). Topics will be assigned individually depending on class size to review the literature, prepare an outline, and a bibliography about the assigned topic. In the outline, the student should look specifically for both the infecting microorganism s and resulting disease characteristics, epidemiological concepts, methods, issues, and problems that remain unresolved and in need of further research. The bibliography and outline should comply with the format provided and should cover at least: 1) the history of discovery of the disease and etiologic agent, 2) the incidence, prevalence, case fatality and mortality rates, demographics and distribution among local, state, national, and worldwide populations, 3) transmission, reservoir, incubation and communicable periods, 4)preventive and control methods, 5) potential for use as a weapon of mass destruction, and 6) potential for epidemic occurrence. 4. Examinations will cover both the lecture material, and readings from the texts. Any student who misses a class session is responsible for obtaining notes or other handout materials from a fellow classmate. No make-up examinations will be given unless arrangements are made with the instructor in advance of the scheduled examination. Any student who fails to take a scheduled examination will receive a zero ( 0 ) for that examination. This same policy will be applied to exercises and projects. COURSE TEXTS Required: Nelson, KE, CM Masters, and NMH Graham. Infectious Disease Epidemiology Theory and Practice. Aspen Publishers Incorporated, Gaithersburg, Maryland, Alternate: Nelson, KE, CM Masters, and NMH Graham. Infectious Disease Epidemiology Theory and Practice. Aspen Publishers Incorporated, Gaithersburg, Maryland, 2000.

120 Useful, but not mandatory: Chin, James, Editor. Control of Communicable Diseases Manual, 18 th Edition. American Public Health Association, Washington, D. C ACADEMIC DISHONESTY Academic honesty is fundamental to the activities and principles of a university. All members of the academic community must be confident that each person's work has been responsibly and honorably prepared, developed, and presented. Any effort to gain an advantage not given to all students is dishonest whether or not the effort is successful. The academic community regards academic dishonesty as an extremely serious matter, with serious consequences that range from a grade of "F" to expulsion from the University. Both cheating and plagiarism are considered academic dishonesty. Cheating refers to any unauthorized assistance during examinations, such as notes or handouts. It also includes either giving or taking the answers to examination questions to/from other student(s). Consequently, the use of cell phones (with or without an internal camera) during examinations, without explicit permission will result in a charge of cheating. Plagiarism is academic "theft", and includes not properly crediting another author for his/her work or idea. Any paraphrase or direct quotation from a published or unpublished work should be properly cited with a footnote or reference. Students must be particularly careful not to engage in plagiarism, even inadvertently, since computers and Internet web browsing seem to facilitate this process. ENABLING ACCOMODATIONS If you have a documented disability that requires academic accommodations, please see me as soon as possible during scheduled office hours. In order to receive accommodations in this course, you must provide me with a Letter of Accommodation from the disability Resource Center ( If you have not already done so, please register with the Disability Resource Center (Room 2 Alumni Gym , [email protected]) for coordination of campus disability services available to students with disabilities.

121 EPI 716 INFECTIOUS AND EMERGING DISEASES EPIDEMIOLOGY Spring 2006 Tentative draft COURSE SCHEDULE Tentative draft Class Date Topic Reading Assignment 1 1/12/09 Introduction and History of Infectious Disease NWG: Epidemiology Chapter 1,2,12 2 1/26/09 Epidemiologic Concepts of Infectious Disease, NWG: Surveillance, Outbreak Investigation, and Geographic Chapters 2,4,5,7 Information Systems 3 2/2/09 Epidemiologic Tools: Microbiology, Modeling, NWG: Molecular Biology, and Study Design Chapters 3, /9/09 Infectious Disease Prevention NWG: Chaps /16/09 Airborne Transmission Tuberculosis, Influenza, and Other NWG: Respiratory Diseases Chaps /23/09 Foodborne and Diarrheal Diseases NWG: Chapter /2/09 MID-TERM EXAMINATION 3/9/09 SPRING BREAK ACADEMIC HOLIDAY 8 3/16/09 Blood-borne Pathogens: Human Immunodeficiency Virus NWG: Chapter 21 and Acquired Immunodeficiency Syndrome 9 3/23/09 Sexually Transmitted Diseases NWG: Chapter /30/09 Viral Hepatitis and Liver Cancer NWG: Chapter /6/09 Vector-borne Diseases NWG: Chaps /16/09 Nosocomial Infections NWG: Chaps /23/09 Emerging and Re-emerging Infectious Diseases NWG: Chapter 13, /30/09 FINAL EXAMINATION

122 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 26, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number CPH 786 b. Title * Doctorial Seminar * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( 1 ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 1 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: 4 g. Course description: Students will attend colloquium sessions that will supplement the core curriculum with additional application. h. Prerequisite(s), if any: Enrollment in the PhD in Epidemiology and Biostatistics program i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / 2009

123 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course will be a requirement in the proposed Ph.D. Epidemiology/Biostatistics program 9. a. By whom will the course be taught? Any faculty member in the Biostatistics or Epidemiology Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per semester 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

124 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

125 CPH 786 Doctorial Seminar This course will provide colloquium sessions that will supplement the core curriculum with additional application.

126 APPLICATION FOR NEW COURSE 1. Submitted by the College of Public Health Date: March 26, 2008 Department/Division proposing course: Biostatistics 2. Proposed designation and Bulletin description of this course: a. Prefix and Number CPH 767 b. Title * Residency Credit * If title is longer than 24 characters, write a sensible title (24 characters or less) for use on transcripts: c. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( 2 ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: d. Please choose a grading system: Letter (A, B, C, etc.) Pass/Fail e. Number of credit hours: 2 f. Is this course repeatable? YES NO If YES, maximum number of credit hours: 6 g. Course description: Students will enroll in this course to complete their research for their dissertation. h. Prerequisite(s), if any: Approval of DGS i. Will this course be offered through Distance Learning? YES NO If YES, please circle one of the methods below that reflects how the majority of the course content will be delivered: Internet/Webbased Interactive video Extended campus Kentucky Educational Television (KET/teleweb) Other Please describe Other : 3. Teaching method: N/A or Community-Based Experience Service Learning Component Both 4. To be cross-listed as: Prefix and Number Signature of chair of cross-listing department 5. Requested effective date (term/year): Fall / 2009

127 APPLICATION FOR NEW COURSE 6. Course to be offered (please check all that apply): Fall Spring Summer 7. Will the course be offered every year? YES NO If NO, please explain: 8. Why is this course needed? This course will be a requirement in the proposed Ph.D. Epidemiology/Biostatistics program in order to fulfill graduate school requirements. 9. a. By whom will the course be taught? Any faculty member in the Biostatistics or Epidemiology Department b. Are facilities for teaching the course now available? YES NO If NO, what plans have been made for providing them? 10. What yearly enrollment may be reasonably anticipated? 5-10 students per year 11. a. Will this course serve students primarily within the department? Yes No b. Will it be of interest to a significant number of students outside the department? YES NO If YES, please explain. The course will be a requirement for the proposed Ph.D. in Epidemiology/Biostatistics. Some of the students in that program may consider Epidemiology their home department. 12. Will the course serve as a University Studies Program course? YES NO If YES, under what Area? AS OF SPRING 2007, THERE IS A MORATORIUM ON APPROVAL OF NEW COURSES FOR USP. 13. Check the category most applicable to this course: traditional offered in corresponding departments at universities elsewhere relatively new now being widely established not yet to be found in many (or any) other universities 14. Is this course applicable to the requirements for at least one degree or certificate at UK? Yes No 15. Is this course part of a proposed new program? YES NO If YES, please name: Ph.D. Epidemiology/Biostatistics 16. Will adding this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that will require this course:

128 APPLICATION FOR NEW COURSE In order to change the program(s), a program change form(s) must also be submitted. 17. The major teaching objectives of the proposed course, syllabus and/or reference list to be used are attached. 18. Check box if course is 400G or 500. If the course is 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 19. Within the department, who should be contacted for further information about the proposed new course? Name: Richard Kryscio Phone: kryscio@ .uky.edu 20. Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature * DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / * DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature * DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature * DATE of Approval by Senate Council Reported by Office of the Senate Council * DATE of Approval by University Senate Reported by Office of the Senate Council *If applicable, as provided by the University Senate Rules. ( Rev 8/07

129 CPH 767: Residency Credit (2 credit hours) Students will enroll in this course in order to complete the graduate school residency requirements. While enrolled in this course students to complete their dissertation research. As per graduate school rules, students must complete a minimum of two semesters of this course.

130 Course Change Forms

131 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 1. Submitted by the College of Date: Department/Division offering course: 2. What type of change is being proposed? Major Minor * * See the description at the end of this form regarding what constitutes a minor change. Minor changes are sent directly from the dean of the college to the Chair of the Senate Council. If the Senate Council chair deems the change not to be minor, the form will be sent to the appropriate Council for normal processing and an notification will be sent to the contact person. PROPOSED CHANGES Please complete all Current fields. Fill out the Proposed field only for items being changed. Enter N/A if not changing. Circle the number for each item(s) being changed. For example: Current prefix & number: Proposed prefix & number: 4. Current Title Proposed Title If title is longer than 24 characters (including spaces), write a sensible title (24 characters or less) for use on transcripts: 5. Current number of credit hours: Proposed number of credit hours: 6. Currently, is this course repeatable? YES NO If YES, current maximum credit hours: Proposed to be repeatable? YES NO If YES, proposed maximum credit hours: 7. Current grading system: Letter (A, B, C, etc.) Pass/Fail Proposed grading system: Letter (A, B, C, etc.) Pass/Fail 8. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. Current: ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: Proposed: ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: 9. Requested effective date (term/year): /

132 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 10. Current teaching method: N/A Community-Based Experience Service Learning Component Both Proposed teaching method (if applicable): Community-Based Experience Service Learning Component Both 11. Current cross-listing: N/A Prefix and Number NAME of current cross-listing DEPARTMENT a. Proposed REMOVE the current cross-listing: b. Proposed ADD a cross-listing: Prefix and Number Signature of chair of proposed cross-listing department 12. Current prerequisites: Proposed prerequisites: 13. Current Bulletin description: Proposed Bulletin description: 14. What has prompted this change? 15. If there are to be significant changes in the content or teaching objectives of this course, indicate changes: 16. Please list any other department that could be affected by the proposed change: 17. Will changing this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that require this course: In order for the course change to be considered, program change form(s) for the programs above must also be submitted.

133 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 18. Is this course currently included in the University Studies Program? Yes No 19. Check box if changed to 400G or 500. If changed to 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 20. Within the department, who should be contacted for further information on the proposed course change? Name: Phone: Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature *DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / *DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature *DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature *DATE of Approval by Senate Council Reported by Office of the Senate Council *DATE of Approval by the University Senate Reported by the Office of the Senate Council *If applicable, as provided by the University Senate Rules. Excerpt from University Senate Rules: ********** SR G.2: Definition. A request may be considered a minor change if it meets one of the following criteria: a. change in number within the same hundred series; b. editorial change in the course title or description which does not imply change in content or emphasis; c. a change in prerequisite(s) which does not imply change in content or emphasis, or which is made necessary by the elimination or significant alteration of the prerequisite(s); d. a cross-listing of a course under conditions set forth in SR E; e. correction of typographical errors. Rev 8/07

134 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 1. Submitted by the College of Date: Department/Division offering course: 2. What type of change is being proposed? Major Minor * * See the description at the end of this form regarding what constitutes a minor change. Minor changes are sent directly from the dean of the college to the Chair of the Senate Council. If the Senate Council chair deems the change not to be minor, the form will be sent to the appropriate Council for normal processing and an notification will be sent to the contact person. PROPOSED CHANGES Please complete all Current fields. Fill out the Proposed field only for items being changed. Enter N/A if not changing. Circle the number for each item(s) being changed. For example: Current prefix & number: Proposed prefix & number: 4. Current Title Proposed Title If title is longer than 24 characters (including spaces), write a sensible title (24 characters or less) for use on transcripts: 5. Current number of credit hours: Proposed number of credit hours: 6. Currently, is this course repeatable? YES NO If YES, current maximum credit hours: Proposed to be repeatable? YES NO If YES, proposed maximum credit hours: 7. Current grading system: Letter (A, B, C, etc.) Pass/Fail Proposed grading system: Letter (A, B, C, etc.) Pass/Fail 8. Courses must be described by at least one of the categories below. Include the number of actual contact hours per week for each category, as applicable. Current: ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: Proposed: ( ) CLINICAL ( ) COLLOQUIUM ( ) DISCUSSION ( ) LABORATORY ( ) LECTURE ( ) INDEPEND. STUDY ( ) PRACTICUM ( ) RECITATION ( ) RESEARCH ( ) RESIDENCY ( ) SEMINAR ( ) STUDIO ( ) OTHER Please explain: 9. Requested effective date (term/year): /

135 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 10. Current teaching method: N/A Community-Based Experience Service Learning Component Both Proposed teaching method (if applicable): Community-Based Experience Service Learning Component Both 11. Current cross-listing: N/A Prefix and Number NAME of current cross-listing DEPARTMENT a. Proposed REMOVE the current cross-listing: b. Proposed ADD a cross-listing: Prefix and Number Signature of chair of proposed cross-listing department 12. Current prerequisites: Proposed prerequisites: 13. Current Bulletin description: Proposed Bulletin description: 14. What has prompted this change? 15. If there are to be significant changes in the content or teaching objectives of this course, indicate changes: 16. Please list any other department that could be affected by the proposed change: 17. Will changing this course change the degree requirements for ANY program on campus? YES NO If YES, list below the programs that require this course: In order for the course change to be considered, program change form(s) for the programs above must also be submitted.

136 APPLICATION FOR CHANGE IN EXISTING COURSE: MAJOR and MINOR 18. Is this course currently included in the University Studies Program? Yes No 19. Check box if changed to 400G or 500. If changed to 400G- or 500-level, you must include a syllabus showing differentiation for undergraduate and graduate students by (i) requiring additional assignments by the graduate students; and/or (ii) the establishment of different grading criteria in the course for graduate students. (See SR 3.1.4) 20. Within the department, who should be contacted for further information on the proposed course change? Name: Phone: Signatures to report approvals: / DATE of Approval by Department Faculty printed name Reported by Department Chair signature / DATE of Approval by College Faculty printed name Reported by College Dean signature *DATE of Approval by Undergraduate Council / printed name Reported by Undergraduate Council Chair signature / *DATE of Approval by Graduate Council printed name Reported by Graduate Council Chair signature *DATE of Approval by Health Care Colleges Council (HCCC) / printed name Reported by Health Care Colleges Council Chair signature *DATE of Approval by Senate Council Reported by Office of the Senate Council *DATE of Approval by the University Senate Reported by the Office of the Senate Council *If applicable, as provided by the University Senate Rules. Excerpt from University Senate Rules: ********** SR G.2: Definition. A request may be considered a minor change if it meets one of the following criteria: a. change in number within the same hundred series; b. editorial change in the course title or description which does not imply change in content or emphasis; c. a change in prerequisite(s) which does not imply change in content or emphasis, or which is made necessary by the elimination or significant alteration of the prerequisite(s); d. a cross-listing of a course under conditions set forth in SR E; e. correction of typographical errors. Rev 8/07

137 Epidemiology Department Faculty CVs

138 Epidemiology Department Faculty Primary Faculty Thomas C. Tucker (Chair) Claudia M. Hopenhayn Steven R. Browning Steven T. Fleming Amit Chadopadhyay Glyn G. Caldwell Adjunct Faculty David M. Manino Andre T. Baron Ann L. Coker Douglas T. Steinke Robert H. McKnight

139 CURRICULUM VITAE of THOMAS C. TUCKER, PhD, MPH UK Cancer Control Program 2365 Harrodsburg Road, Suite A230 University of Kentucky Lexington, Kentucky Office: (859) ext 225 FAX: (859) ACADEMIC AND PROFESSIONAL EXPERIENCE Markey Cancer Center University of Kentucky Lexington, Kentucky Associate Director for Cancer Prevention and Control 12/04 - Present Senior Director for Cancer Surveillance 06/00 - Present Acting Director for Cancer Control 07/98-06/00 Associate Director for Cancer Control 09/84-07/98 Principal Investigator NCI-SEER Contract 02/01 - Present Principal Investigator CDC-NPCR Grant 09/94 - Present Director, Kentucky Cancer Registry 06/00 - Present Associate Director, Kentucky Cancer Registry 04/90-06/00 College of Public Health University of Kentucky Lexington, Kentucky Chair, Epidemiology Department 05/04 - Present Director, Epidemiology Division 06/00-05/04 Associate Professor (with Tenure) 06/00 - Present Department of Health Services College of Health Sciences University of Kentucky Lexington, Kentucky Associate Professor (with Tenure) 04/90-11/03 Assistant Professor of Health Administration 09/84-04/90 Kalamazoo Community Hospital Oncology Program Borgess Medical Center Kalamazoo, Michigan Administrative Director 03/81-09/84 Grand Rapids Clinical Oncology Program Butterworth Hospital Grand Rapids, Michigan Administrative Director 11/75-03/81

140 American Cancer Society Midwestern Area Office Des Plaines, Illinois Area Public Education Director 06/73-11/75 American Cancer Society National Office New York, New York Public Education Representative 12/71-06/73 American Cancer Society Missouri Division West Metro Area Office Kansas City, Missouri Associate Director 4/71-12/71 Program Representative 6/69-4/71 OEO/CAP Agency Kansas City, Missouri Research Assistant and Consultant 06/68-01/69 EDUCATION University of Kentucky, Lexington, KY Ph.D Major: Medical Sociology Minor: Organizational Theory University of Michigan, Ann Arbor, MI M.P.H Major: Medical Care Organization Minor Emphasis Areas: Epidemiology and Biostatistics University of Oklahoma, Norman, OK Certificate Special Topics Course: Community Organization University of Kansas, Lawrence, KS B.A Major: Political Science Minor Emphasis Area: Communications HONORS Calum S. Muir Award for lifetime contributions to cancer surveillance, North American Association of Central Cancer Registries, Toronto, Canada, June O'Donnell Award for Outstanding Achievement as a Graduate Student in Sociology, University of Kentucky, Sociology Department Faculty, May 1996.

141 Elected to Alpha Eta Society, University of Kentucky Chapter, April Outstanding Service Award, Kalamazoo Community Hospital Oncology Program, Kalamazoo, Michigan, August Award for Outstanding Contribution to Cancer Control, Association of Community Cancer Centers, Washington, D.C., March PROFESSIONAL ACTIVITY International Canadian Council of Cancer Registries Member, 1999 to Far East Medical University, Khabarovsk, Russia Development of collaborative public health and health service delivery research, Ministry of Public Health, Quito, Ecuado Pilot Project for development of a computerized data system for hospitals in Ecuador, 1988 to Kentucky/Ecuador Partners of the Americas Member, Health Committee, 1987 to North American Association of Central Cancer Registries (NAACCR) President, 1999 to President-elect, Chair, Search Committee for Executive Director, Member, Board of Directors, 1996 to Chairperson, Certification Committee, 1997 to Chairperson, Uniform Data Standards Committee, 1993 to Member, High Quality Data Standards Committee, 2002 to present. Member, 1989 to Present.

142 National National Coordinating Council for Cancer Surveillance Member, 1999 to Centers for Disease Control and Prevention (CDC) Member, National Program of Cancer Registries, Scientific Advisory Committee, 2000 to Present. Member, National Program of Cancer Registries, Advisory Board, 1996 to Member, Health Education Specialist Training, Faculty, 1998 to National Cancer Institute (NCI) Member, Grant Review Panel, CISNET, Washington, D.C., Co-chairperson, Evaluation Committee, Appalachian Leadership Initiative on Cancer, 1993 to Member, Special Review Committee, NAACCR Conference Grant, February, Member, Special Review Committee, Cancer Control Research Unit, Yale University, Bethesda, Maryland, March, Member, Site Visit Team, Cancer Control Research Unit, Yale University, New Haven, Connecticut, October Member, Grant Review Panel, Rural Cancer Control Initiative, Washington, D.C., August Member, Grant Review Panel, Cancer in Special Populations, Washington, D.C., February, Special Site Visitor, Data-Based Cancer Control Interventions Program, Georgia Department of Public Health, Atlanta, November Member, Grant Review Panel, Avoidable Mortality from Cancer in Native American Populations, Washington, D.C., Member, Grant Review Panel, Tobacco Use Prevention and Cessation Among Native American Populations, Washington, D.C., Chairperson, Grant Review Panel, Data-Based Cancer Control Interventions Program, Washington, D.C., Special Site Visitor, Data-Based Cancer Control Interventions Program, North Carolina Department of Public Health, Member, Site Visit Team, Cancer Control Research Unit, Yale University, 1988.

143 Member, Interim Review Committee, Data-Based Cancer Control Interventions Program, Washington, D.C., Member, Grant Review Panel, Data-Based Cancer Control Intervention Program, Member, Site Visit Team, Cancer Control Research Unit, Yale University, Member, Site Visit Team, Cancer Care Research Program, Kaiser Permanente Research Unit, Member, Site Visit Team, Cancer Control Network Program, Johns Hopkins University, Member, Site Visit Team, Cancer Control Outreach Program, Memorial Sloan- Kettering Cancer Center, Center for Substance Abuse Treatment (CSAT) Member, Cross-Site Evaluation Committee, 1995 to Member, Cross-Site Evaluation Sub-committee on Publication Policies, 1995 to Association of University Programs in Health Administration (AUPHA) Reviewer, Undergraduate Programs in Health Administration, Atlanta, GA, Member, Health Administration Undergraduate Program Review, Washington, D.C., March Reviewer, Undergraduate Programs in Health Administration, Washington, D.C., Member, 1986 to Present. Association of Community Cancer Centers (ACCC) Chairperson, Special Task Force on Membership, Chairperson, Subcommittee for Administrative Standards, Vice Chairperson, Standards Committee, Member, Nominating Committee, Chairperson, Program Committee, Member, Board of Trustees, Delegate Member,

144 State and Local MidSouth Division of the American Cancer Society Member, Triad Project, 1999 to Member, Committee to Establish Measurable Goals, 1999 to Member, Breast Cancer Task Force, 1993 to University of Kentucky (UK) Member, Administrative Council, College of Public Health, 2000 to Present. Member, Academic Affairs Committee, College of Public Health, 2001 to Present. Member, Research Committee, College of Allied Health, 1999 to Member, Promotion and Tenure Committee, College of Allied Health Professions, 1995 to Member, Taskforce for the Establishment of the Health Policy Research Institute, Member, Medical Center Institutional Review Board, 1992 to Member, University Senate, 1991 to Member, Equal Opportunity Committee, 1989 to Member, Student Affairs Committee, College of Allied Health Professions, Member, Six Year Review Committee, College of Allied Health Professions, Member, Six Year Review Committee, Survey Research Center, Member, Kentucky Health Survey Technical Advisory Committee, Survey Research Center, 1987 to Member, Academic Affairs Committee, College of Allied Health Professions, 1987 to Faculty Advisor, Student Chapter, American College of Health Care Executives, 1987 to Member, Task Force to review the Medical Center Computing Plan, Member, Search Committee for Director of the Survey Research Center, Center for Developmental Change, 1986.

145 Member, Faculty Council, College of Allied Health Professions, 1985 to 1987 and 1991 to Member, Advisory Committee, Survey Research Center, 1985 to Member, Cancer Committee, University Medical Center, 1985 to Present. Co-Chairperson, Support Services Committee, Development of a Masters Program in Health Administration, College of Allied Health Professions, Member, Executive Committee, Markey Cancer Center, 1984 to Present. Member, Committee on Centers of Excellence, College of Allied Health Professionals, 1984 to Kentucky Department of Health Services (KDHS) Member, Breast Cancer Advisory Committee, 1998 to Present. Member, Steering Committee, Data-Based Cancer Control Intervention Study, 1990 to Alliant Health Care Systems, Inc. Consultant, Development of Rural Hospital Transition Grants, Clinical Oncology Program of Grand Rapids, Michigan Consultant, Reorganization of the Grand Rapids Clinical Oncology Program, March, Consultant, Development of a Computerized Data System for Managing Patients on Clinical Research Protocols, November, Kentucky Hospital Association (KHA) Member, Health Services Database Committee, 1995 to Consultant, Development of a Grant to Study Dual Licensed Hospital Beds in Kentucky, Consultant, Evaluation of Data on Hospitalized Medically Indigent Patients, Presented to the State Legislature, Kentucky Medical Association (KMA) Ex Officio Member, Cancer Committee, 1995 to Present. Community Hospital Oncology Program of Flint, Michigan

146 Consultant, A Population Based Study of Cancer Incidence and Mortality in Genesee County, 1987 to Michigan Department of Public Health (MDPH) Member, CSAS Target Cities Advisory Committee, 1994 to Member, Special Task Force for Implementation of a Cancer Incidence Registry, 1983 to Michigan Division of the American Cancer Society (MDACS) Member, Field Services Committee, 1980 to Member, Board of Directors, 1979 to Chairperson, Public Education Committee, 1979 to Member, Public Education Committee, 1978 to Chairperson, Adult Education Sub-committee, 1978 to Michigan State University (MSU) Member, Search Committee for Director of the Cancer Center, Member, Central Planning Task Force, Development of a Cancer Center, 1975 to Member, Advisory Council, Development of a Cancer Center, 1975 to RESEARCH AND CREATIVE PRODUCTIVITY Publications Tucker T, Huang B, Klinglesmith R, Tuckson, W. Colorectal Screening Practices in Kentucky. Journal of the Kentucky Medical Association. Vol. 3, No. 8, August [peer-reviewed] Lengerich EJ, Tucker TC, Powell RK, Colsher P, Lehman E, Ward AJ, Siedlecki JC, and Wyatt SW. Cancer incidence in Kentucky, Pennsylvania, and West Virginia: Disparities in Appalachia. Journal of Rural Health, Vol. 21, No. 1, Winter [peer-reviewed] Tucker T Cancer Incidence Report. Kentucky Cancer Registry. Lexington (KY): University of Kentucky, Markey Cancer Control Program, Hopenhayn C, Moore DB, Huang B, Redmond J, Tucker TC, Kryscio RJ, and Boissonneault GA. Patterns of Colorectal Cancer Incidence, Risk Factors, and Screening

147 in Kentucky. Southern Medical Journal, Vol. 97, No. 3, PP , Mar [peerreviewed] Hopenhayn C, Pieretti M, Tucker T, Khattar NH, and Redmond J. Increasing the Use of the Kentucky Cancer Registry as a Research Tool: an Epidemiologic Pilot Study of Ovarian Cancer. Journal of Registry Management, Vol. 31, No. 2, PP 58-66, [peerreviewed] Wyatt S, Huang B, Tucker T, et al. Geographic Trends in Cervical Cancer Incidence and Mortality in Kentucky, Journal of the Kentucky Medical Association, Vol. 102, January [peer-reviewed] Tucker T Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, McDavid K, Tucker T, et al. Cancer Survival in Kentucky and Health Insurance, Archives of Internal Medicine, Vol. 163, No. 18, Oct. 13, [peer-reviewed] Beaulieu J, Massy C, Tucker T, et al. Rural-Urban Variations in Breast-Conserving Surgery in Kentucky, Journal of the Kentucky Medical Association, Vol. 101, Oct [peer-reviewed] Wyatt S, Huang B, and Tucker T. The Impact of Changing Age-Adjustment Population Standards on Kentucky Cancer Incidence Rates, Journal of the Kentucky Medical Association, Vol. 101, February [peer-reviewed] Pieretti M, Hopenhayn-Rich C, Cao M, and Tucker T. Heterogeneity of Ovarian Cancer: Relationships Among Histological Group, Stage of Disease, Tumor Markers, Patient Characteristics, and Survival, Cancer Investigation, Vol. 20, No. 1, PP 11-23, [peer-reviewed] Tucker T Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Tucker, T and Howe H. Measuring the Quality of Population-Based Cancer Registries, Journal of Registry Management, Vol. 8, No.1, PP 41-45, Spring [peer-reviewed] Wingo P, Luke E, O Brien K, Tucker T. Population-Based Patterns of Care Studies, Journal of Registry Management, Vol. 8, No. 1, PP 5-17, Spring [peer-reviewed] Tucker T Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Friedell G, Tucker T, et al. Cervical Cancer in Kentucky, Journal of the Kentucky Medical Association, Vol. 98, Sept [peer-reviewed] Fleming S, Scutchfield F, and Tucker T. Managerial Epidemiology, Health Administration Press, Friedell G, Tucker T, and Ross F. The Impact of Poverty and Education on Lung and

148 Cervical Cancer in Appalachian Kentucky, Journal of Registry Management, Vol. 20, No.3, [peer-reviewed] Howe H, Fulton J, Tucker T, and Kohler B. Adopting the HL7 Standard for Cancer Registry Work: Clarifying Unresolved Issues, Journal of Registry Management, Aug [peer-reviewed] Noland M, Kryscio R, Riggs R, Linville L, and Tucker T. The Effectiveness of a Tobacco Prevention Program for Adolescents, American Journal of Public Health (May 1999). [peer-reviewed] Tucker T, Howe H, and Weir H. Certification for Population-based Cancer Registries. Journal of Registry Management, pp , Feb [peer-reviewed] Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Noland M, Kryscio R, Riggs R, Linville L, and Tucker T. Relationship of Tobacco use to Alcohol and Marijuana Among Adolescents. Journal of Drug Education, [peerreviewed] Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Friedell G, Linville L, Rubio A, Wagner W, and Tucker T. What Practitioners Should Know About Community Cancer Control, Cancer Practice, Vol. 5, No. 6, pp , Nov [peer-reviewed] Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Cao Y, Powell D, Conway P, Tucker T, and Pieretti M. Loss of Chromosome 17 in Ovarian Cancer Represents the Second Inactivating Event for the P53-Suppressor Gene. Genes, Chromosome and Cancer, [peer-reviewed] Tucker T, Ross F, and Friedell G. Using Population Based Cancer Registries to Target Limited Screening Resources Toward Minorities and Underserved Populations. Journal of Registry Management, Vol. 23, No. 2, pp , May, [peer-reviewed/invited] Noland M, Kryscio R, Riggs R, Linville L, and Tucker T. The Effectiveness of a Tobacco Prevention Program with Adolescents in a Tobacco Producing Region. American Journal of Public Health, [peer-reviewed] Noland M, Kryscio R, Riggs R, Linville L, and Tucker T. Relationship of Personal Tobacco - Raising Parental Smoking and Other Factors in Tobacco Use Among Adolescents Living a Tobacco-Producing Region, Addictive Behaviors, Vol. 21, No. 3, pp , [peer-reviewed]

149 Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Schuette H, Tucker T, Brown M, Potosky A, and Samuel T. The Costs of Cancer Care in the U.S., Oncology, Vol. 9, No. 11, pp 19-22, November [peer-reviewed/invited] Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Tucker T and Friedell G. Using Cancer Registry Data in Primary Care Practice, Primary Care and Cancer, Vol. 14, No. 3, pp , March, [peer-reviewed/invited] Tucker T and Friedell G Kentucky Cancer Incidence Report, Kentucky Cancer Registry, University of Kentucky, Tucker T and Friedell G Kentucky Cancer Incidence, Kentucky Cancer Registry, University of Kentucky, Friedell G, Tucker T, et al. The Incidence of Cervical Disease in an Appalachian Population, The Journal of NCI, Vol. 84, No. 13, pp , [peer-reviewed] Bogue R and Tucker T. Methodology in The Strategies and Environments of America's Small Rural Hospitals, Seavey W, Berry D, and Bogue R. (Eds.), American Hospital Association, Hospital Research and Education Trust, Chicago, IL, Noland M, Kryscio R, Riggs R, Linville L, and Tucker T. Use of Snuff Chewing Tobacco and Cigarettes Among Adolescents in a Tobacco-Producing Area, Addictive Behaviors, Vol. 15, pp , [peer-reviewed] Noland M, Kryscio R, Riggs R, Linville L, Perritt L, and Tucker T. Saliva Cotinine and Thiocyanate: Chemical Indicators of Smokeless Tobacco and Cigarette Use in Adolescents, Journal of Behavioral Medicine, Vol. 11, No.5, pp , April [peer-reviewed] Tucker T, Friedell G, Stallones L, et al. Cancer Mortality in Rural Appalachian Kentucky, Appalachian Databank Report #6, University of Kentucky, November, Berry D, Shelby R, Tucker T, and Seavey J. Frontier Hospitals - An Endangered Species and Public Policy Issues, Hospitals and Health Services Administration, Vol. 33, No. 4, pp , Winter, [peer-reviewed] Robinson T and Tucker T. Allied Health Staffing Patterns Among Kentucky Hospitals, Kentucky Hospitals, p 32, Fall Berry D, Tucker T, and Seavey J. Efficacy of System Management or Ownership as Options for Distressed Small Rural Hospitals, Journal of Rural Health, Vol. 3, No.2, pp.61-75, July [peer-reviewed] Tucker T. Overview: The Community Hospital Oncology Program, Engstrom P, Anderson P, and Mortenson L, eds., Advances in Cancer Control III: Health Care Financing and Research, Liss, N.Y., pp 89-90, April 1986.

150 Tucker T. Services Associated with Successful Rural Hospitals, Kentucky Hospitals, Vol. 2, No. 2, pp , December Tucker T. An Organized System for Cancer Care in the Hospital, Michigan Hospitals, Vol. 21, No. 4, pp 9-11, April [invited] White N and Tucker T. Developing an Integrated, Computerized Oncology Nursing Research Data Base, Engstrom P, Anderson P and Mortenson L, eds., Advances in Cancer Control Epidemiology and Research, Liss, NY 156: , Stott P. and Tucker T. Comparison of Data Elements in Guidelines Developed Independently in Community Hospital Oncology Programs, in Engstrom P, Anderson P, and Mortenson L, eds., Advances in Cancer Control: Research and Development, Liss, NY 120: , Tucker T, Moorhead E, Borst J, et al. Patient Management Guidelines: A Rational Approach to Improving Community Cancer Care, Family and Community Health, 4:23-35, [peer-reviewed/invited] Tucker T and Moorhead E. The Grand Rapids Clinical Oncology Program, Cancer Program Bulletin, Association of Community Cancer Centers, 4:3-5, Giele J, Dillard J, Wilmes K, and Tucker T. Profiles for Planning: Resource Allocation Priority Analysis, Technical Report, Human Resources Corporation, Kansas City, Missouri, Abstracts/Presentations Tucker, T.C. Using Cancer Registry Data for Cancer Control, presented at the NAACCR Annual Meeting, Boston, Massachusetts, June Tucker, T.C. Measuring the Quality of Central Cancer Registry Data, presented at the NAACCR Annual Meeting, Salt Lake City, Utah, June Tucker, T.C. The Uses and Limitations of Population-Based Cancer Registry Data, presented at the Intercultural Cancer Council and Baylor College of Medicine 9 th Annual Biennial Symposium, Washington, D.C., March Tucker, T.C. Communicating Cancer Risk, presented at the CDC 2003 Cancer Conference, Atlanta, Georgia, September Tucker, T.C. Interpreting Variations in the Burden of Cancer, presented at the NCI and CDC Joint Cancer Surveillance Institute, San Jose, California, January Tucker, T.C. Using Cancer Registry Data for Cancer Control, presented at the NAACCR annual meeting; Honolulu, Hawaii, June Tucker, T.C. Using Population-based Cancer Surveillance Data in Research, presented at the NAACCR Annual Meeting in Miami, Florida, June 2001.

151 Tucker, T.C. Completeness of Case Ascertainment, presented at the NAACCR Annual Meeting in New Orleans, April Tucker, T.C. The Relationship Between Data Quality and Use, presented at the NAACCR Annual Meeting in Chicago, Illinois, April Tucker, T.C. Measuring Case Ascertainment in Population-based Cancer Registries, presented at the North American Association of Central Cancer Registries Annual Meeting in Vancouver, British Columbia, Canada, April Tucker, T.C., The Use of Registry Data for Improving the Early Detection of Breast Cancer, presented at the CDC International Cancer Conference, Atlanta, Georgia, September Tucker, T.C., A Rank Sum Technique for Identifying Counties with the Greatest Need for Breast Cancer Screening, presented at the CDC International Cancer Conference, Atlanta, Georgia, September Tucker, T.C., Epidemiology of Prostate Cancer in Kentucky, presented at the ACS Prostate Cancer Symposium, Louisville, Kentucky, June Tucker, T.C., Case Completeness: How Complete is Complete Enough?, presented at the Annual Meeting of the National Cancer Registrars Association, Las Vegas, Nevada, May Tucker, T.C., Developing a Constituency for Central Cancer Registries, presented at the Annual Meeting of the North American Association of Central Cancer Registries, Boston, Massachusetts, April Tucker, T.C., The Use of Cancer Registry Data in Research, presented at the Annual Meeting of the National Cancer Registrars Association, Miami, Florida, June Tucker, T.C., Cancer Care Expenditures in the U.S.: Past, Present and Future, presented at the 1995 Quality of Life Symposium, Long Beach, California, March Tucker, T.C., Using Cancer Registry Data to Target Geographic Areas for Breast Cancer Screening, Abstract, Annual Meeting of the Association of Central Cancer Registries, Niagara on the Lake, Ontario, Canada, Tucker, T., Kilbourn, P. and Muller, W., Cancer Incidence and Mortality in Genesee County, Michigan, Abstract, 1990 Annual Meeting of the Association of Community Cancer Centers, Washington, D.C., March Thompson, J.R., Phillips, B.A., Cabelka, J. and Tucker, T., 1989 Kentucky Hospital Smoking Survey, Abstract, 1990 Annual Scientific Meeting, Kentucky Thoracic Society, Louisville, Kentucky, March Seavey, J., Berry, D.E. and Tucker, T.C., Public Policy and Rural Hospitals, Abstract, 1989 Annual Meeting, American Public Health Association, Chicago, Illinois, November 1989.

152 Noland, M.P., Kryscio, R.J., Riggs, R.S., Linville, L.H., Perritt, L.J. and Tucker, T.C., Use of Snuff, Chewing Tobacco and Cigarettes among Adolescents in a Tobacco- Producing Area, Abstract, American School Health Association Annual Meeting, September Thompson, J.R., and Tucker, T.C., Lung Cancer Mortality in Rural Appalachian Kentucky, Abstract, 1989 Annual Scientific Meeting, Kentucky Thoracic Society, Lexington, Kentucky, March Noland, M., Kryscio, R., Riggs, R., Linville, L., Perritt, L., and Tucker, T., Saliva Cotinine and Thiocyanate: Chemical Indicators of Smokeless Tobacco and Cigarette Use in Adolescents, Abstract, National Convention, American School Health Association, September Stallones, L., Nuckols, J. and Tucker, T., Cancer Clusters in Rural Appalachia, Abstract, National Conference on Clustering of Health Events, Atlanta, Georgia, September Stelling, C., Powell, D., Mattingly, S. and Tucker, T., Atypical Hyperplasia of the Breast: Radiographic Pathologic Correlation, Abstract, American Roentgen Ray Society Annual Meeting, San Francisco, California, May Tucker, T. and Berry, D., Factors Effecting Distress or Prosperity in Small Rural Hospitals, Abstract, American Public Health Association Annual Meeting, Washington, D.C., November Raviteh, M., Youel, D., Moorhead, E., Tucker, T., et.al., Questionnaires and Current Practice: A multi-method Approach to CME Needs Assessment in Oncology, Abstract, American Association for Cancer Education, Grant Activity (Current) Co-Investigator, Pilot Study of Insulin-Like Growth Factors, Diet and Risk of Colon Cancer in a Population, at Case Western Reserve, American Cancer Society (Extramural). Principal Investigator, SEER Contract, National Cancer Institute, Contract No. HHSN C, August 1, 2005 through July 31, 2010, total award $6,896,214 (Extramural). Principal Investigator, National Cancer Prevention and Control Program, Centers for Disease Control Cooperative Agreement No. U55/CCU , Sept 30, 2002 through June 29, 2007, total award, $1,393,373 (Extramural). (Completed)

153 Principal Investigator, SEER Contract, National Cancer Institute, Contract No. 2-PC-15104, approved and funded February 15, 2001 through July 31, 2005, Total award $2,801,074 (Extramural). Principal Investigator, National Cancer Prevention and Control Program, Centers for Disease Control Cooperative Agreement No. U75/CCU , approved and funded Sept 30, 1994 through June 30, 2002 (Extramural). Co-Principal Investigator, Comparing Areas with Low and High Rates of Colon Cancer in Kentucky, Centers for Disease Control and Prevention (Extramural). Principal Investigator, Feasibility Study of Patterns of Care for Colon Cancer, American Cancer Society Contract, total award, $26,000 (Extramural). Co-Principal Investigator. Central Appalachian Leadership Initiative on Cancer, National Cancer Institute Grant No. Ca-91-11, approved and funded October October 1999, total award $1,255,918 (Extramural). Co-Principal Investigator. Databased Interventions for Cancer Control in Kentucky, Cancer Control Research Grant No. 89-CA-14, National Cancer Institute, October 1990 through September 1997, in cooperation with the State Department of Health Services. Total Award $1,200,000. (Extramural) Senior Research Analyst. Cancer Information Service, National Cancer Institute Grant No. NCI-CO , approved and funded, January 1, 1990 through December 31, Total award, $1,105,510. (Extramural) Co-Principal Investigator. A Study of the Patterns of Care for Hospitalized Medicare and Medicaid Patients in Kentucky to 1986, Kentucky Peer Review Organization, approved and funded, 1989 to Total award, $9000 and data tapes containing information on all 1.6 million Medicare and Medicaid hospital discharges in Kentucky between July 1982 and June (Extramural). Co-Principal Investigator. A Study of Small Rural Hospitals in the U.S., Pew Charitable Trust in cooperation with the American Hospital Association and the National Rural Health Association, approved and funded August 1988 through July Total award, $28,350. (Extramural) Research Analyst. A Study of Cervical Cancer in Eastern Kentucky, Centers for Disease Control in cooperation with the State Department of Health Services, Contract No , approved and funded October 1986 through September Total award, $914,000. (Extramural). Co-Principal Investigator. Development of a Computerized Paired Community Laboratory System for Cancer Control Research, American Cancer Society Intrainstitutional Grant No. IN-163, approved and funded November 1986 through November Total award, $1,800. (Intramural) Research Analyst. Pilot Study of Smokeless Tobacco Use Among Adolescents in Kentucky, National Cancer Institute Grant No. 86-CA-02, approved and funded January 1986 through December Total award $35,000. (Extramural)

154 Co-Principal Investigator. Workshop Promoting Patient Welfare in Oncology Clinical Trials, National Institutes of Health, Office for the Protection from Research Risks Contract No. 263-MD , approved and funded Total award, $8,114. (Extramural) Co-Principal Investigator, Patterns of Care Study, National Cancer Institute Grant No. 3-U S1, approved and funded Total award, $23,500. (Extramural) Administrative Director and Principal Author, Kalamazoo Community Clinical Oncology Program, National Cancer Institute Grant No U10-CA-35184, approved and funded Total award $202,000. (Extramural) Administrative Director and Principal Author. Kalamazoo Community Hospital Oncology Program, National Cancer Institute Contract No. N01-CN-25598, approved and funded Total award, $364,000. (Extramural) Administrator and Principal Author. Biological Markers for Breast Cancer, National Cancer Institute Grant No. 1-U10-CA35178, approved and funded Total award $187,000. (Extramural) Administrative Director and Principal Author. Grand Rapids Clinical Oncology Program, National Cancer Institute Contract No. N01-CN-75347, approved and funded Total award, $534,000. (Extramural)

155 CURRICULUM VITAE CLAUDIA MARIA HOPENHAYN 2365 Harrodsburg Road, Suite B100 Lexington, KY Phone: (859) ext. 307 Fax:(859) EDUCATION Ph.D. May 1996 Department of Epidemiology University of California, Berkeley M.P.H. May 1989 Dept. of Epidemiology and Biostatistics University of California, Berkeley B.A. May 1986 Department of Physical Education University of California, Berkeley B.A. March 1978 Language & Translation (Spanish-English) Universidad del Salvador, Buenos Aires, Argentina RESEARCH AND ACADEMIC EXPERIENCE Associate Professor 2005-present College of Public Health, University Assistant Professor (tenure track) of Kentucky Research Associate Professor Dept.of Prev.Medicine and Environ. Research Assistant Professor Health, University of Kentucky Research Epidemiologist School of Public Health University of California, Berkeley Research Consultant California Public Health Foundation - for California Environmental Protection Agency Senior Research Associate Reproductive and Cancer Hazard Assessment Section, California Department of Health Services Research Assistant 1988 Neurology Department Kaiser Hospital, Oakland, CA Research Assistant 1985 Laboratory of Developmental and Aging Neuroendocrinology University of California, Berkeley 1

156 PUBLICATIONS Journal Articles Hertz-Picciotto, I., Hopenhayn-Rich, C., Golub, M., Hooper, K. The Risks and Benefits of Taking Aspirin During Pregnancy. Epidemiologic Reviews, Vol. 12, Donald, J.M., Hooper, K., Hopenhayn-Rich, C. Reproductive and Developmental Toxicity of Toluene: A Review. Environmental Health Perspectives, 1991, Vol. 94: Smith, A.H., Hopenhayn-Rich, C., Bates, M., Goeden, H., Hertz-Picciotto, I., Duggan, H., Wood, R., Kosnett, M.J., Smith M.T. Cancer risks from arsenic in drinking water. Environmental Health Perspectives, 1992; 97: Bates, M.N., Smith, A.H., Hopenhayn-Rich, C. Arsenic ingestion and internal cancers: A review. American Journal of Epidemiology, 1992; 135: Hopenhayn-Rich, C., Smith, A.H., Goeden, H. Epidemiological studies do not support the methylation hypothesis for inorganic arsenic. Environmental Research, 1993; 60: Smith A.H., Hopenhayn-Rich, C., Warner, M., Biggs, M.L., Moore, L., Smith M.T. Bladder cell micronucleus as a biomarker of effect for arsenic exposure. Journal of Toxicology and Environmental Health, 1993; 40: Engel, R.R., Hopenhayn-Rich, C., Receveur, O., Smith, A.H. Vascular effects of chronic arsenic exposure: a review. Epidemiologic Reviews, 1994; 16: Moore, L.E., Smith, A.H., Hopenhayn-Rich, C., Biggs, M.L., Warner, M.L., Kalman, D.A., Smith, M.T. Increased bladder cell micronuclei found in two populations environmentally exposed to arsenic in drinking water. Clinical Chemistry, 1995; 41: Hopenhayn-Rich, C., Biggs, M.L., Fuchs, A., Bergoglio, R., Tello, E., Nicolli, H., Smith, A.H. Bladder cancer mortality associated with arsenic in drinking water in Cordoba, Argentina. Epidemiology, 1996; 7: Hopenhayn-Rich, C., Biggs, M.L., Smith, A.H., Kalman, D.A., Moore, L.E. Methylation study of a population environmentally exposed to arsenic in drinking water. Environmental Health Perspectives. 1996;104: Hopenhayn-Rich, C., Biggs, M.L., Kalman, D.A., Moore, L.E., Smith, A.H. Arsenic methylation patterns before and after change from high to lower arsenic concentrations in drinking water, Environmental Health Perspectives. 1996;104: Moore, L.E., Smith, A.H., Hopenhayn-Rich, C., Biggs, M.L., Kalman, D.A., Smith, M.T. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water, Cancer Epidemiology, Biomarkers and Prevention, 6:31-36, Biggs, M.L., Kalman, D.A., Moore, L.E., Hopenhayn-Rich, C., Smith, M.T., Smith, A.H. Relationship of urinary arsenic to intake estimates and a biomarker of effect, bladder cell micronuclei, Mutation Research. 386: ,

157 Moore LE, Smith AH, Hopenhayn-Rich C, Biggs ML, Kalman DA, Smith MT. Decrease in bladder cell micronucleus after intervention to lower the concentration of arsenic in drinking water. Cancer, Epidemiology, Biomarkers and Prevention, 6:1051-6, Hopenhayn-Rich C, Biggs ML, Smith AH. Lung and kidney cancer mortality associated with arsenic in drinking water in Córdoba, Argentina. International Journal of Epidemiology, 27: , Steinmaus C, Moore LE, Hopenhayn-Rich C, Biggs ML, Smith AH. Arsenic in drinking water and bladder cancer. Cancer Investigation, 18: , Hopenhayn-Rich C, Browning S, Hertz-Picciotto I, Ferreccio C, Peralta, C, Gibb, H. Chronic arsenic exposure and risk of infant mortality in two areas of Chile. Environmental Health Perspectives, 108: , Pieretti M, Hopenhayn-Rich C, Khattar N, Cao Y-M, B. Huang, Tucker TC. Heterogeneity of ovarian cancer: relationship between histological group, stage of disease, tumor markers and survival. Cancer Investigation, 20: 11-23, Hopenhayn-Rich C, Stump M, Browning S, Huang, B. Regional assessment of atrazine exposure and incidence of breast and ovarian cancers in Kentucky. Archives of Environmental Contamination and Toxicology, 42: , Pi J, Yamauchi H, Guifan S, Kumagai Y, Sun G, Yoshida T, Aikawa H, Hopenhayn-Rich C, Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environmental Health Perspectives, 110: , Hopenhayn C, Jenkins T, Petrik, J. The burden of lung cancer in Kentucky. Journal of the Kentucky Med. Association; 101: 19-24, Hopenhayn C, Ferreccio C, Browning SR, Huang B, Peralta C, Gibb H, Hertz-Picciotto H. Arsenic Exposure from Drinking Water and Birth Weight. Epidemiology, 14: , Moore LE, Smith AH, Eng C, DeVries S, Kalman D, Bhargava V, Chew K, Ferreccio C, Rey OA, Hopenhayn C, Biggs ML, Bates MN, Waldman FM. P53 Alterations in Arsenic and Tobacco Exposed Bladder Carcinomas. Carcinogenesis. 24 (11): , Hopenhayn C, Huang B, Christian J, Ferreccio C, Peralta C, Attalah R, Kalman D. Profile of arsenic methylation during pregnancy. Environmental Health Perspectives, 111: , Wyatt SW, Huang B, Tucker TC, Redmond J, Hopenhayn C. Geographic Trends in Cervical Cancer Incidence and Mortality in Kentucky, Journal of the Kentucky Medical Association, 102:11-14, Bates M, Rey OA, Biggs ML, Hopenhayn C, Moore LE, Kalman D, Steinmaus C, Smith AH Case-control study of bladder cancer and exposure to arsenic in Argentina. American Journal of Epidemiology, 159:381-9, Hopenhayn C, Moore D, Tucker T, Kryscio R, Boisonneault G, Huang B. Regional Patterns of Colorectal Cancer Incidence, Risk Factors and Screening Usage in Kentucky. Southern Medical Journal, 97(3):216-23,

158 Hopenhayn C, Pieretti M, Tucker T, Khattar NH, Redmond J. Increasing the Use of the Kentucky Cancer Registry as a Research Tool: An Epidemiologic Pilot Study of Ovarian Cancer. Journal of Registry Management, 31:58-66, Hopenhayn C, Bush H, Christian A, Shelton B. Comparison of invasive cervical cancer rates in three Appalachian states.prev Med Nov-Dec; 41(5-6): Schoenberg NE, Hopenhayn C, Christian A, Knight EA, Rubio A. An in-depth and updated perspective on determinants of cervical cancer screening among central Appalachian women. Women Health. 2005;42(2): Christian WJ, Hopenhayn C, Centeno J Distribution of urinary selenium and urinary arsenic measures among pregnant women exposed to moderate arsenic levels in drinking water. Environ Res Jan; 100 (1): Hahn EJ, Rayens MK, Hopenhayn C, Christian WJ, Rasnake E. Perceived risk and interest in screening for lung cancer in smokers. Res Nurs Health Jul 17;29(4): Steinmaus C, Bates MN, Yuan Y, Kalman D, Rey OA, Biggs ML, Hopenhayn C, Moore LE, Hoang BK, Smith AH. Arsenic methylation and bladder cancer risk in case-control ctudies in Argentina and the United States. J Occup Environ Med May;48(5): Hopenhayn C, Bush H, Bingcang A, Hertz-Picciotto I Arsenic Exposure from Drinking Water and Anemia During Pregnancy. J Occup Environ Med Jun;48(6): Hopenhayn C. Health Effects from Arsenic in Drinking Water: Epidemiologic Review. Elements 2006, 2: Bates MN, Hopenhayn C, Rey O, Moore LE, Bladder cancer and mate consumption in Argentina: a casecontrol study. Cancer Lett. 2007, 246: Steinmaus C, Moore LE, Shipp M, Kalman D, Rey OA, Biggs ML, Hopenhayn C, Bates MN, Zheng S, Smith AH. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 And T1, and metabolism of arsenic. J Toxicol Environ Health 2007, 70: Crosby RA, Schoenberg N, Hopenhayn C, Moore G, Melhan W. Correlates of intent to be vaccinated against HPV: An exploratory study of college-age women. Sexual Health, 2007: Hopenhayn C, Tucker TC, Christian A, Christian WJ. Patterns of cervical cancer risk in Kentucky J Ky Med Assoc. 2007;105(5): Hopenhayn C, Christian A, Christian WJ, Schoenberg, N. Human papillomavirus vaccine: knowledge and attitudes in two Appalachian Kentucky counties. Cancer Causes Control. 2007;18(6): Christian J, Hopenhayn C, Christian A, Koch A. High rates of hepatitis B- and C-related hospitalizations in Applachian Kentucky. Under revision for re-submission. Hopenhayn C, King JB, Christian A, Huang B, Christian WJ, Variations in the incidence rates of cervical cancer within the Appalachian region. Submitted. 4

159 Masterson E, Hopenhayn C, Christian J. The Role of Mental Health in Predicting Health Protective Behavior: Mammography Screening. Submitted. Hopenhayn C, Bush HM, Schenberg NE, Moore G, Crosby R. Factors influencing female college students intent to receive the Human Papillomavirus (HPV) vaccine. Submitted. Book Chapters Hopenhayn-Rich, C. "Chapter 4: Heavy Metals", in Environmental Epidemiology: A Project for Latin America and the Caribbean, Pan American Center for Human Ecology and Health, Panamerican Health Organization, Smith AH, Hopenhayn-Rich C, Biggs ML, Moore L, Dale J, Warner M, Bates M, and Engel R. Epidemiological study designs to address potential high bladder cancer risks from arsenic in drinking water. In Arsenic, Exposure and Health, Edited by W.R. Chappell, C.O. Abernathy, C.R. Cothern, Science and Technology Letters, Northwood, Hopenhayn-Rich C, Hertz-Picciotto I, Browning S, Ferreccio C, Peralta, C. Reproductive and developmental effects associated with chronic arsenic exposure, In Arsenic Exposures and Health Effects, Eds. Chapell, Abernathy and Calderon, Elsevier, The Netherlands, Hopenhayn-Rich C. Cáncer de vejiga y exposición arsenical en Argentina, in Metodología Epidemiológica Aplicada Estudios de Salud Ambiental. Book Chapter, Instituto Nacional de Salud Publica, Eds. Romieu, I., Borja, V., Hernández, M., México, Committee member/author of: Veterans and Agent Orange, Update The National Academies Press, Wahsington, DC Committee member/author of: Veterans and Agent Orange, Update The National Academies Press, Wahsington, DC Other (Proceedings, Letter to Editors) Hopenhayn-Rich, C. Metabolic Effects of Alcohol on Human Neuroblastoma In Vitro. In Proceedings of the Summer Research Program 1985, Graduate Division, U.C. Berkeley. Moore LE, Titenko-Holland N, Warner ML, Smith AH, Hopenhayn-Rich C, Smith MT. Use of fluorescence in situ hybridization (FISH) to measure cytogenetic damage in exfoliated cells of humans exposed to environmental mutagens. Environ Molec Mutagen, 23: suppl 23, abstract Moore LE, Warner ML, Smith AH, Hopenhayn-Rich C, Kalman DA, Fanning EW, Biggs ML., Titenko- Holland N., Smith MT. Increased micronuclei in exfoliated urothelial cells from chronic arsenic ingestion. Proc Amer Assoc Cancer Res, 35: abstract Smith, A.H., Hopenhayn-Rich, C., Biggs, M.L., Moore, L.E., Kalman, D., Oyanguren, C., Marchetti, N. Marcadores biológicos de exposición y efecto relacionados con el contenido arsenical del agua de beber en el Desierto de Atacama, Proceedings from the II Jornadas Arsenicismo Laboral y Ambiental, Antofagasta, Chile, November, Smith, A.H., Biggs, M.L., Hopenhayn-Rich, C., Kalman, D. Letter to the editor: "Arsenic risk assessment", Environmental Health Perspectives, 1995;103:

160 Hopenhayn-Rich C, Biggs ML., Smith AH. Letter to the editor: Response to Arsenic and bladder cancer mortality Epidemiology, 7:558; Biggs M, Haque R, Moore L, Smith A, Ferrecio C, Hopenhayn-Rich C. Arsenic-Laced Water in Chile, Letter to the editor, Science, 281:785, Smith AH, Biggs ML, Haque R, Hopenhayn-Rich C, Moore LE, Wright CC. Feasibility of New Epidemiologic Studies of Low Level Arsenic, AWWA Research Foundation and American Water Works Association, U.S.A., Hopenhayn-Rich C, Stump M. Lung cancer in the commonwealth: A far too common disease. Lung Cancer in Kentucky Policy Brief vol. 1, 1:1-4, winter 2001, newsletter of the Lung Cancer Research Project, University of Kentucky and University of Louisville. Hopenhayn-Rich C, Stump M. Lung cancer in the commonwealth: A closer look at the data. Lung Cancer in Kentucky Policy Brief vol. 1, 2:1-4, winter 2002, newsletter of the Lung Cancer Research Project, University of Kentucky and University of Louisville. Hopenhayn-Rich C, Jenkins T, Petrik J. The severity of lung cancer in the commonwealth. Policy Brief vol. 2, 1:1-4, spring 2002, newsletter of the Lung Cancer Research Project, University of Kentucky and University of Louisville. Hopenhayn C, Jenkins T, Petrik J. The severity of lung cancer in the commonwealth. Policy Brief vol. 2, 1:1-4, spring 2002, newsletter of the Lung Cancer Research Project, University of Kentucky and University of Louisville. Hopenhayn C, Hertz-Picciotto I, Browning SR, Huang B. Letter to the editor, response to Arsenic in Drinking Water, Epidemiology 15:255-56, Redmond J, Hopenhayn C A Cancer Clip from the Kentucky Cancer Registry, Journal of the Kentucky Medical Association, 102:272, Hopenhayn C, Christian J. Response to Commentary "Concentrations in Spot Urine Samples need Adjustment...to Arsenic in Drinking Water", Environmental Research, PRESENTATIONS Smith AH, Bates MN, Hopenhayn-Rich C. Evidence that Arsenic is a Major Source of Environmental Cancer Risk. Presented at the XIIth Scientific Meeting of the International Epidemiological Association Meeting, Los Angeles, California, August 7, Donald JM, Hooper K, Hopenhayn-Rich C. Developmental Toxicity of Toluene: Evidence from Animal and Human Studies. Poster presentation at the 2nd meeting of the International Society for Environmental Epidemiology, Berkeley, California, August 13-15, Hopenhayn-Rich C. Pilot Epidemiological Biomarker Study of a Population with a Drinking Water Supply High in Arsenic Content. Poster presentation at the Fourth Annual Research Symposium, U.C. Toxic Substances Research and Teaching Program, University of California, Santa Barbara, November 3,

161 Hopenhayn-Rich C, Smith AH. Epidemiological Biomarker Studies of Populations Exposed to Inorganic Arsenic from Drinking Water. Poster presentation at the Fifth Annual Research Symposium, U.C. Toxic Substances Research and Teaching Program, University of California, San Francisco, October 19, Hopenhayn-Rich C. Evaluación de riesgo de cánceres internos causados por el hidroarsenicismo y determinaciones biológicas de exposición y efecto. Presented at the Hospital Nacional Clínicas, Córdoba, Argentina, December 13, Smith AH, Hopenhayn-Rich C, Bates M, Goeden H, Hertz-Picciotto I, Duggan H, Wood R, Kosnett MJ, Smith MT. Cancer risks from arsenic in drinking water. Presented at the International Seminar "Presencia de Arsénico en el Ambiente y su Incidencia en Salud", Santiago, Chile, May 25-29, Hopenhayn Rich C, Smith AH. Relación entre arsénico y cánceres internos: métodos de investigación. Presented at the National Academy of Sciences, Cordoba, Argentina, June 4, Hopenhayn-Rich C, Smith AH and Goeden HM. Epidemiological evidence does not support the threshold methylation theory for the carcinogenicity of inorganic arsenic. Presented at the 4th meeting of the International Society for Environmental Epidemiology, Cuernavaca, Mexico, August 26-29, Smith AH, Hopenhayn-Rich C, Warner M, Engel R, Bates M, and Goeden HM. Epidemiological study designs to examine bladder cancer risks from arsenic in drinking water. Presented at the 4th meeting of the International Society for Environmental Epidemiology, Cuernavaca, Mexico, August 26-29, Smith AH, Hopenhayn-Rich C. Effects of arsenic exposure on human health: a state of the art. Presented at "Medio Ambiente y Desarrollo Sustentable: Control Ambiental de Arsénico", meeting sponsored by the Universidad de Chile and the Instituto de Salud Pública, Santiago, Chile, October 8, Hopenhayn-Rich C, Smith AH and Goeden HM. Assessment of inorganic arsenic and its metabolites in persons drinking water containing high arsenic levels, Presented at the Thirty-first Hanford Symposium on Health and the Environment, Richland, Washington, October 19-23, Smith, A.H Hopenhayn-Rich C, Warner M, Biggs ML, Moore L, Smith MT. Bladder Cell Micronucleus as a Biomarker of Effect for Arsenic Exposure. Presented at the Thirty-first Hanford Symposium on Health and the Environment, Richland, Washington, October 19-23, Smith AH, Hopenhayn-Rich C, Biggs ML, Moore L, Dale J, Warner M, Bates M, Engel R. Epidemiological study designs to address potential high bladder cancer risks from arsenic in drinking water. Presented at the International Conference on Arsenic Exposure and Health Effects, July 27-30, 1993, New Orleans, Louisiana. Hopenhayn-Rich C, Smith AH, Biggs ML, Warner M, Moore L, Dale J, Rich B, Kalman D, Atallah R, Vega F, Oyanguren C. Urinary speciation and methylation patterns of populations chronically exposed to high arsenic levels from drinking water in the U.S. and Chile. Presented at the International Conference on Arsenic Exposure and Health Effects, New Orleans, July 27-30, Smith AH, Hopenhayn-Rich C, Engel R, Warner M, Biggs ML, Dale J. Epidemiologic methods for investigating arsenic in drinking water and bladder cancer, Presented at the International Society for Environmental Epidemiology Conference, Stockholm, Sweden, August 15-18, Hopenhayn-Rich C. Assessing the Cancer Risk of Saccharin and Sodium Saccharin. Discussant Session Epidemiology of Bladder Cancer and Saccharin, San Francisco, California, April,

162 Smith AH, Hopenhayn-Rich C, Moore LE, Biggs ML, Barroga R. Epidemiological and biomarker findings cocerning arsenic and bladder cancer in Chile and Argentina. Presented at the Workshop on arsenic: epidemiology and PBPK modeling, Annapolis, Maryland, June 27-28, Smith AH, Hopenhayn-Rich C. Comparación de la presencia de micronúcleos en células de vejiga en sujetos expuestos a altas concentraciones de arsénico en agua y no expuestos. Presented at the meeting: Arsénico en el Ambiente y la Salud Humana: Estudios de Efectos a Nivel Celular y a Nivel Poblacional, sponsored by the Panamerican Health Organization, Santiago, Chile, July 18, Hopenhayn-Rich C, Biggs ML, Smith AH, Fuchs A., Bergoglio R, Nicolli H. Increased bladder, lung and kidney cancer risks associated with high arsenic levels in drinking water in a region of Argentina. Presented at the International Society for Environmental Epidemiology Conference, North Carolina, September 18-21, Biggs ML, Hopenhayn-Rich C, Kalman DA, Smith AH, Moore LE. Assessing chronic arsenic exposure using urine samples and questionnaire data. Presented at the International Society for Environmental Epidemiology Conference, September 18-21, 1994, North Carolina, U.S.A. Smith AH, Moore LE, Hopenhayn-Rich C, Biggs ML, Kalman DA, Barroga VR, Smith MT. Bladder cell micronuclei prvalence before and after providing low asenic water to a population with high arsenic exposure from drinking water. Presented at the International Society for Environmental Epidemiology Conference, North Carolina, September 18-21, Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman DA, Moore LE. Arsenic speciation analysis of urinary metabolites in a population highly exposed to inorganic arsenic from drinking water. Presented at the International Society for Environmental Epidemiology Conference, North Carolina, September 18-21, Hopenhayn-Rich C, Biggs ML, Smith AH, Moore LE, Kalman DA, Arsenic methylation in a chronically exposed population: a multifactorial analysis of metabolite distribution. Presented at the SEGH Second International Conference on Arsenic Exposure and Health Effects, San Diego, California, June 12-14, Kalman DA, Atallah R, Smith AH, Biggs ML, Hopenhayn-Rich C. Speciation of arsenic in biological samples. Presented at the SEGH Second International Conference on Arsenic Exposure and Health Effects, San Diego, California, June 12-14, Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman DA, Moore LE. Distribution of urinary arsenic metabolites before and after reduction of arsenic levels in drinking water supply. Presented at the International Society for Environmental Epidemiology Conference, Noordwijkerhout, The Netherlands, August 30-Sept. 1, Smith AH, Biggs ML, Hopenhayn-Rich C, Moore LE, Smith MT, Waldman F. New ecological findings concerning arsenic and bladder cancer and proposed tumor biomarker studies. Presented at the International Society for Environmental Epidemiology Conference, Noordwijkerhout, The Netherlands, August 30-Sept. 1, Hopenhayn-Rich C, Biggs ML, Moore LE, Kalman DA, Smith AH. Effect of smoking on arsenic methylation in a population with high arsenic exposure. Presented at the International Society for Environmental Epidemiology Conference, Edmonton, Canada, August 17-21,

163 Biggs ML, Hopenhayn-Rich C, Moore LE, Kalman DA, Smith AH. Comparison of exposure indices based on urinary arsenic with estimates based on daily intake. Presented at the International Society for Environmental Epidemiology Conference, Edmonton, Canada, August 17-21, Hopenhayn-Rich C, Biggs ML, Moore LE, Smith AH, Kalman DA. Methylation study of populations in the Atacama Desert exposed to arsenic from drinking water. International Seminar on Arsenic, Health Effects, Remediation Methods and Treatment Costs, Santiago, Chile, October 8-10, Hopenhayn-Rich C, Hertz-Picciotto I, Johnson KD. Reproductive and developmental effects associated with chronic arsenic exposure. Presented at the Third International Conference on Arsenic Exposure and Health Effects, San Diego, California, July 12-15, Hopenhayn-Rich C, Hertz-Picciotto I, Johnson KD. Increased fetal and infant mortality associated with high arsenic exposure. Presented at the International Society for Environmental Epidemiology Conference, Boston, Massachusetts, U.S.A. August 15-19, Biggs ML, Hopenhayn-Rich C, Smith AH. Increased mortality from esophageal cancer in northwestern Region of Province of Cordoba, Argentina. Presented at the International Society for Environmental Epidemiology Conference, Boston, Massachusetts, U.S.A. August 15-19, Moore L, Biggs ML, Hopenhayn-Rich C, Smith AH. Methodological Considerations in Molecular Epidemiologic Studies Employing Biomarkers of Disease and Susceptibility. Presented at the International Society for Environmental Epidemiology Conference, Boston, August 15-19, Hopenhayn-Rich C, Tucker T, Gallion N, Khattar NH, Pieretti M. Are specific reproductive factors associated with distinct genetic markers in ovarian cancer? Presented at the AACR Annual Meeting Philadelphia, PA. April 10-14, Hopenhayn-Rich C, Ferreccio C, Hertz-Picciotto I, Peralta C, Browning S, Gibb H. Prospective Pregnancy Follow-up Study and Arsenic Exposure. Presented at the International Society for Environmental Epidemiology Conference, Athens, Greece, September, Stump M, Hopenhayn-Rich C, Browning S, Huang B. Atrazine exposure and risk of ovarian cancer. Presented at the Agricultural Safety and Health in a New Century Conference, Cooperstown, NY, April Hopenhayn-Rich C, Ferreccio C, Peralta C, Browning S, Huang B, Gomez-Caminero A, Hertz-Picciotto I, Gibb, H. Arsenic exposure from drinking water and reproductive effects: pregnancy cohort study in Chile. Presented at the 6th International Symposium of Metal Ions in Biology and Medicine, San Juan, Puerto Rico, May Hopenhayn-Rich C, Peralta C, Browning SR, Huang B, Ferreccio C, Gomez-Caminero A, Hertz-Picciotto I. Arsenic exposure and reproductive outcomes: preliminary report from a pregnancy cohort study in Chile. Presented at the Fourth International Conference on Arsenic Exposure and Health Effects, San Diego, California, June, Hopenhayn-Rich C, Moore DB, Tucker TC, Kryscio RJ, Boissonneault GA, Huang B. Using BRFSS data with a state cancer registry to investigate colorectal cancer trends. Presented at The 18th Annual Behavioral Risk Factor Surveillance System (BRFSS) Conference, Atlanta, GA, March,

164 Hopenhayn-Rich C, Moore DB, Tucker TC, Kryscio RJ, Boissonneault GA, Huang B, Stump M. Colorectal Cancer in Kentucky: Regional Variations in Incidence, Mortality, Screening, and Risk Factors. Presented at the Appalachian Spring: A Rural Health Research Symposium, at the University of Kentucky, April 19-20, Hopenhayn-Rich C. Using BRFSS Data With A State Cancer Registry To Investigate Colorectal Cancer Trends. Presentation to the National Center for Chronic Disease Prevention and Health Promotion, Division of Cancer Prevention and Control, Atlanta, GA, July 9, Hopenhayn-Rich C, Browning SR, Ferreccio C, Huang B, Peralta C, Hertz-Picciotto I, Gomez-Caminero, A, Gibb H. The Effects of Arsenic in Drinking Water on Birth Weight. Presented at the International Society for Environmental Epidemiology meeting in Garmisch-Partenkirchen, September 2-5, Hopenhayn-Rich C, Stump M, Browning S, Huang B. Use of secondary data to characterize exposure to environmental pollutants in drinking water, Presented at the International Society for Environmental Epidemiology meeting in Garmisch-Partenkirchen, September 2-5, Gomez-Caminero A, Pankow J, Hopenhayn-Rich C, Ferreccio C, Peralta C, Hertz-Picciotto I. Effects of Arsenic on Biomarkers of Cardiovascular health. Presented at the International Society for Environmental Epidemiology meeting in Garmisch-Partenkirchen, September 2-5, Hopenhayn-Rich C. Research Projects using KCR Data. Presented at the 15th Annual Advanced Cancer Registrars Workshop, Lexington, KY, September 27-28, Hopenhayn-Rich, C. Regional Variation in Incidence, Behavioral Risk Factors and Screening of Colorectal Cancer in Kentucky. University of Kentucky Prevention Research Center Seminar Series, October 29, Hopenhayn C, Huang B, Browning SR, Peralta C, Ferreccio C, Hertz-Picciotto I, Gibb H, Centeno J. Exposure to arsenic in drinking water during pregnancy. To be presented at the Fifth International Conference on Arsenic Exposure and Health Effects, San Diego, California, July, Gomez-Caminero A, Hertz-Picciotto I, Pankow J, Hopenhayn C, Ferreccio C. Biomarkers of alterations in cardiovascular health and exposure to arsenic in drinking water in Chile. To be presented at the Fifth International Conference on Arsenic Exposure and Health Effects, San Diego, California, July, Bates MN, Hopenhayn C, Rey OA, Smith AH. Association between bladder cancer and maté consumption in Argentina. Presented at the International Society for Environmental Epidemiology meeting in Vancouver, August Hopenhayn, C. Reproductive Effects and Arsenic methylation profiles in Chilean populations. Invited presentation at the International Symposium Chile-USA Toxicogenomic: A New Area in Risk Assessment of Diseases Related to Environmental Pollutants, September 30 October 2, 2002, Santiago, Chile. Hopenhayn C, Bush HM, Randles KM, Boissonneault GA. Does Arsenic Exposure Increase the Risk of Anemia During Pregnancy? Presented at the International Society for Environmental Epidemiology meeting in Perth, Australia, September 24-26, Hopenhayn C, Huang B, Jenkins T, Rubio A, Schoenberg N, Knight E, Beaulieu J, Christian A. 10

165 Prioritizing High-Risk Counties for an Intervention Study of Invasive Cervical Cancer in Appalachian Kentucky. Presented at the Annual Meeting of the American Publich Health Association, San Francisco, November, Hopenhayn C, Bush H, Christian A, Huang B. Patterns of Cervical Cancer Occurrence among Appalachian Subgroups. Presented at the 18th National Conference on Chronic Disease, Prevention and Control in Washington, DC, February 18-20, Hopenhayn, C, Christian A, Bush H, Christian, J. Patterns of cancer risks and rates and risk factors in Kentucky, presented at the Relationship of Tobacco and HPV with Lung, Head and Neck and Cervical Cancer Symposium, Markey Cancer Center, University of Kentucky, May 20, Christian WJ, Hopenhayn C, Centeno J. Correlation of urinary selenium levels with urinary excretion and metabolite distribution of inorganic arsenic species. Presented at the International Society for Environmental Epidemiology meeting in New York, August 1-4, Fletcher RA, Anglin MK, Hopenhayn C, Christian A Cervical Cancer Screening and Health Disparities in an Eastern Kentucky County. Presented at the meeting of the Society for Applied Anthropology (SFAA), 2004 Hopenhayn C, Christian A, Fletcher RA, Anglin M. Attitudes Toward Pap and HPV Testing and Health Surveys in an Appalachian Community. Presented at the 19th National Conference on Chronic Disease, Atlanta, March 1-3, 2005 Hopenhayn C, Christian A, Bush A, Christian WJ. Lung and cervical cancer in Kentucky: Characterization of high risk sub-groups. Presented at the Kentucky Public Health Association Conference, Louisville, Kentucky, April 19-21, Christian WJ, Hopenhayn C, Bush H, Christian A. Cancer risk factors among smokers in Kentucky. Presented at the Kentucky Public Health Association Conference, Louisville, Kentucky, April 19-21, Christian A, Hopenhayn C, Bush A, Christian WJ. Knowledge and attitudes toward human papillomavirus (HPV) and screening for cervical cancer in two Appalachian Kentucky counties Presented at APHA, Philadelphia, December Hopenhayn C, Christian A, Christian WJ. Factors associated with interest in human papillomavirus (HPV) testing and potential acceptance of HPV vaccine in two rural Appalachian counties. Presented at the Congress of Epidemiology, Seattle, Washington, June 21-24, Hopenhayn C, Goel S. Reproductive and developmental effects associated with environmental arsenic exposure. Presented at the International Society for Environmental Epidemiology meeting in Paris, France, September 2-6, Hopenhayn C, Christian WJ. Naturally-occurring arsenic in drinking water and human health effects. Presented at the Geological Society of Ameica meeting in Philadelphia, PA, October 22-25, Bhandari M, Scutchfield FD, Hopenhayn C. A multilevel analysis of preterm births in Kentucky, Presented at APHA, Boston, MA, November 4-8, Hopenhayn C, Schoenberg N, Crosby R. Factors associated with HPV vaccine acceptance among female college students. Presented at APHA, Boston, MA, November 4-8,

166 Materson EA, Hopenhayn C, Charnigo RJ. Role of mental health in predicting health protective behavior: Mammography screening. Presented at APHA, Boston, MA, November 4-8, Christian A, Hopenhayn C, Christian WJ. Acceptance of the human papilloma virus (HPV) vaccine among women in two Appalachian counties. Presented at the Kentucky Public Health Association Conference, Louisville, Kentucky, April, Christian WJ, Hopenhayn C, Christian A, Koch A, Geography of viral hepatitis in Kentucky: implications for liver cancer control and prevention. Presented at the Kentucky Public Health Association Conference, Louisville, Kentucky, April, Hopenhayn C, Christian A, Christian WJ HPV Vaccine Acceptance in Kentucky: Results of the 2006 BRFSS. Presented at the CDC Cancer Conference, Atlanta, August 13-16, Christian A, Christian WJ, Koch A, McIntosh D, Hopenhayn C. Liver cancer risk and hepatitis testing in a high risk rural population: A collaborative approach. Presented at the CDC Cancer Conference, Atlanta, August 13-16, FUNDING/GRANTS: Title: University of Kentucky BRFSS Data Analysis and Dissemination (Pending contract) Funding Source: Kentucky Department for Public Health January 1, 2008 June 31, 2008 PI: C. Hopenhayn Title: Lung Cancer Survival in Kentucky: A Multifactorial Approach Funding Source: Kentucky Lung Cancer Research Program September 1, 2007 August 30, 2009 PI: C. Hopenhayn Title: SEER Expansion Program Source: National Cancer Institute P.I.: Thomas Tucker; CH Role on Project: Key Personnel-Epidemiologist Duration: 2/01 to 2/07 Marty Driesler Liver Cancer Project: Epidemiology of Hepatitis B and C in Eastern Kentucky Funding Source: CDC January 1, July 31, 2007 CH Role: Co-PI Liver Cancer Study Title: Epidemiology Core Source: Kentucky Lung Cancer Project Fund CH Role: Lead Epidemiologist Duration: 7/01/01-6/30/07 Survey of Cervical Cancer Screening, Knowledge, Attitudes and Practices in Two Appalachian Kentucky Counties 12

167 Funding Source: Research Support Grant for the Office of the Vice President for Research, University of Kentucky; College of Public Health, University of Kentucky July 1, 2005 June 30, 2006 PI: C. Hopenhayn Population-based Information on Knowledge and Attitudes Regarding Human Papillomavirus (HPV) testing and vaccination (2006 BRFSS questions) Funding Source: Mid South Cancer Information Service (CIS) January 1, 2006 December 31, 2006 PI: C. Hopenhayn Title: Designing Strategies for Understanding and Decreasing the Burden of Cervical Cancer in Appalachian Communities Source: American Cancer Society PI: Claudia Hopenhayn 8/01/03-3/30/05 Title: Analysis of Arsenic Exposure and Anemia During Pregnancy Source: Environmental Protection Agency PI: Claudia Hopenhayn Duration: 9/15/02-6/30/05 Title: Cervical Cancer Outreach Demonstration Project Source: Appalachian Regional Commission/CDC PI: Angel Rubio CH Role: Co-Investigator Duration: 10/01/02-9/30/05 Title: Characterizing the risk of invasive cervical cancer among Appalachian sub-populations.source: American Cancer Society PI: Claudia Hopenhayn 8/01/02-7/31/03 Title: Improving Surveillance of Pesticides and Other Agricultural-Related Poisonings in Kentucky and Tennessee. Source: Centers for Agricultural Disease and Injury Prevention, Education and Research, Department of Health and Human Services (CDC/NIOSH funded). P.I.: R. McKnight; CHR Role on project: Key Personnel-Epidemiologist Duration: 9/30/01 9/29/06 Title: Kentucky Cardiovascular Health Program Source: Kentucky Department of Public Health P.I.: Phillip Curd; CHR Role on Project: Epidemiologist Duration: 7/1/01 6/30/02 Title: University of Kentucky Prevention Research Center: Controlling Cancer in Appalachia Source: Centers for Disease Control and Prevention P.I.: Stephen Wyatt; CHR Role on Project: Key personnel - Epidemiologist Duration: 10/00-9/03 13

168 Title: Chronic Arsenic Exposure from Drinking Water and Reproductive Effects Source: Environmental Protection Agency. P.I.: Claudia Hopenhayn-Rich Duration: 12/98-12/02. Title: Environmental Exposures and Cancer, Project of the Southeast Center for Agricultural Health and Injury Prevention Source: National Institute of Occupational Health and Safety Project P.I.: Claudia Hopenhayn-Rich; Center P.I.: Robert McKnight; Duration: 10/99 9/01 Title: Assessing the Burden of Colorectal Cancer in Kentucky Source: Centers for Disease Control P.I.: Claudia Hopenhayn-Rich Duration: 10/99-9/01 Title: Health Effects of Toxic Substances P.I. Allan Smith, University of California, Berkeley. Role: Subcontract to Claudia Hopenhayn-Rich Duration: 4/99-3/00 Title: Are specific reproductive factors associated with distinct genetic markers in ovarian cancer? Source: Women s Health Initiative, Chandler Medical Center, University of Kentucky. P.I.: Claudia Hopenhayn-Rich Duration: 7/88-6/99 ACADEMIC ACTIVITIES - UNIVERSITY OF KENTUCKY Course Teaching Spring 2003: PM 780: Occupational and Environmental Epidemiology Fall 2003: SPH 605: Introduction to Epidemiology Spring 2004: PM 770: Occupational and Environmental Epidemiology Fall 2004: SPH 605: Introduction to Epidemiology Spring 2005: CPH 617: Occupational and Environmental Epidemiology Fall 2005: CPH 605: Introduction to Epidemiology, two sections Spring 2006: CPH 617: Occupational and Environmental Epidemiology Fall 2006: CPH 605: Introduction to Epidemiology Spring 2007: CPH 617: Occupational and Environmental Epidemiology Fall 2007 : CPH 605: Introduction to Epidemiology Course Guest Lectures Fall 1997: PM 521 (Epidemiology): Ecologic Studies/Environmental Epidemiology Fall 1998: PM 521: Environmental Epidemiology The case of arsenic PM 601 (Occup. and Environmental Health): Environmental Toxicology Fall 1999: PM 521:Environmental Epidemiology; Confounding (theory/methods) PM 601: Environmental Toxicology Fall 2000: HSM 250 (Introduction to Epidemiology): Sample Study, measures of association PM 601: Environmental Toxicology Fall 2001: PM 601 Arsenic: Environmental Exposure and Effects 14

169 HSM 250: Sample Study ES 620 (The Natural, Biological and Medical Sciences in Environmental Systems): Occupational and Environmental Epidemiology Fall 2002: PM 601: Environmental Epidemiology SPH 911: Environmental Epidemiology; Health Effects of Arsenic Exposure Fall 2003: PM 601: Arsenic: Environmental Exposure and Effects Summer 2004: SPH : Special Topics in Public Health: Geographic Information Systems and Public Health Fall 2004: SPH-718: Special Topics: Molecular Epidemiology and Cancer Prevention Arsenic Methylation and Cancer Risk Fall 2005: SPH-718: Special Topics: Molecular Epidemiology and Cancer Prevention Arsenic Methylation and Cancer Risk Spring 2006: TOX-680; Advamced Toxicology: Arsenic and Cancer CPH-605; Epidemiology Fall 2006: CPH-718: Special Topics: Molecular Epidemiology and Cancer Prevention Arsenic Biomarkers and Cancer Risk CPH-601: Occupational and Environmental Health Spring 2007: TOX-680; Advamced Toxicology: Arsenic and Cancer CPH-718 Special Topics in Public Health:Cancer Epidemiology; Occupational and Environmental Cancer Epidemiology Fall 2007: CPH-718: Special Topics: Molecular Epidemiology and Cancer Prevention Arsenic and Cancer Risk CPH-728:Special Topics in Public Health: Advanced Agricultural Health; : Atrazine Exposure and Health Effects CPH-201: Introduction to Public Health. Global Health Presentations at the University of Kentucky College of Public Health Research Day; Shoulder to Shoulder/Hombro a Hombro, UK-Ecuador Brigade, October, College of Public Health, Grand Rounds: International Health and Trip to Ecuador, 2006 (with T.Young) Markey Cancer Center, University of Kentucky, May 20, 2004 Relationship of Tobacco and HPV with Lung, Head and Neck and Cervical Cancer Symposium Patterns of cancer risks and rates and risk factors in Kentucky Appalachian Cancer Network Works in Progress Seminar, November 2002 Issues and Methods in Cervical Cancer Studies. Prevention Research Center, Seminar Series, 2001 Regional Variations in Incidence, Behavioral Risk Factors and Screening of Colorectal Cancer in Kentucky. Appalachian Spring: A Rural Health Research Symposium, April 19-20, 2001 Regional Variations in Incidence, Mortality, Screening, and Risk Factors. Department of Pathology: Seminar presentation, Are Specific Reproductive Factors Associated with Distinct Genetic Markers in Ovarian Cancer? College of Allied Health Lecture: Environmental Epidemiology in Introd. to Epidemiology (HSM 250), Arsenic and Old Lace: An Environmental Perspective. Seminar Presentation,

170 Graduate Center for Toxicology Effects of Chronic Exposure to Arsenic in Drinking Water, Toxicology Seminar, University of Kentucky - Committees University Senate member, Global Health Committee Chair: Maternal and Child Committee member: College of Public Health, Faculty Council member CPH-APT Committee: Member CPH Epi/Biostat PhD Development Committee: Marty Driesler Cancer Project, Executive Committee Member Scientific Advisory Board Member, Markey Cancer Control Program, 2005-present Research Committee, Chair. College of Public Health, Admissions and Student Affairs Committee, Member, College of Public Health, Search Committee member, Department of Epidemiology, Search Committee for Interim Chair, Dept. of Preventive Medicine and Environmental Health, Other UK-KY Service UK-Ecuador Partnership Building: Team member of six UK colleges, Ecuador, November Eastern Kentucky University, invited guest lecture in HEA 820 Global Health: Arsenic in Drinking Water: Multiple Health Outcomes and Global Perspective. Fall Kentucky Dept. of Health Services: Quantitative and Qualitative Approaches to Data Analysis Workshop: Key Concepts for MCH Professionals Team taught with S. Browning and D. Reed. UK-Ecuador Service Learning-Practicum Team co-leader (with T. Young): May, Shoulder to Shoulder Kentucky-Ecuador: Advisory Committee Member Lyman T. Johnson Doctoral and Post-Doctoral Fellowship Award Committee Member- Office of the Executive Vice President for Research; Member CPH Research Day Symposium: Organizing Committee, Sturgill Award Committee Member Office of the Dean for Graduate Studies 16

171 OTHER PROFESSIONAL AND RESEARCH ACTIVITIES Institute of Medicine; Committee Member, Health Effects in Vietnam Veterans of Exposure to Herbicides, ; again to serve on Committee. University of Arizona, Tucson; Member of External Review Committee, University of Arizona Superfund Program, 2004-Present ASPH/CDC Allan Rosenfield Global Health Fellowship Program Review Committee, 2007 Environmental Protection Agency; Invited Panel Member Science Advisory Board, Arsenic Review Panel, August 2005 to December 2006 National Institute of Occupational Health and Safety (NIOSH); Reviewer for the Alice Hamilton Award, 2004 American Public Health Association; Abstract Reviewer for 2003 and 2004 Annual Conferences Environmental Protection Agency; Invited Panel Member Federal Insecticide, Fungicide and Rodenticide Act, Scientific Advisory Panel (FIFRA SAP), Environmental Protection Agency. Characterization of atrazine cancer epidemiology data, Washington DC, July 17-18, Proposal Reviewer for EPA: a. WHO: International Program on Chemical Safety, World Health Organization, 2003 b. WHO: Office of the Protection of the Human Environment, World Health, Organization, c. New York University: Effects of Breast Cancer in Relationship to Environmental Hazards in Rockland County and the East side of Manhattan, International Symposium Chile-USA; Invited participant Toxicogenomic: A New Area in Risk Assessment of Diseases Related to Environmental Pollutants, September 30 October 2, 2002, Santiago, Chile. Sponsored by Universidad de Chile, U.S. National Institute of Environmental Health Sciences and Union of Toxicology. Invited presentation as conference speaker: Arsenic Exposures and Reproductive Effects. Arsenic in New England: A Multidisciplinary Conference, May 2002, Manchester, New Hampshire, sponsored by the Center for Environmental Health Sciences at Dartmouth and by NIEHS. National Academy of Sciences; Short term assignment to evaluate reproductive effects of arsenic in drinking water, Environmental Protection Agency; Invited Panel Member Federal Insecticide, Fungicide and Rodenticide Act, Scientific Advisory Panel (FIFRA SAP), Environmental Protection Agency. Evaluation of CCA pesticide and potential hazard to children from playground treated wood. Washington D.C., October 22-26, Managua, Nicaragua; Invited Symposium Speaker International Conference on Skin and the Environment, Managua, Nicaragua, June 15-16, Sponsored and invited by the Panamerican Health Organization. University of Cincinnati; Seminar Presentation 17

172 Reproductive Effects from Arsenic Exposure. Division of Epidemiology and Biostatistics, Department of Environmental Health, College of Medicine, Cincinnati, OH, May 3, National Institute for Occupational Health and Safety; Invited Presentation Arsenic Reproductive and Carcinogenic Effects. National Institute of Occupational Health and Safety (NIOSH), Cincinnati, OH, May 4, 2001 World Health Organization Temporary Assignment in Inner Mongolia, China. September, Panamerican Health Organization (PAHO); Invited Reviewer Reviewer and Tester of the new Perinatal Information System (SIP2000) of the Latin American Center for Perinatology and Human Development (PAHO/WHO); technical and epidemiologic assessment. October, World Health Organization, International Porgram on Chemical Safety Task Group on Arsenic and Arsenic Compounds, Temporary Advisor Queensland Health Scientific Services and National Research Centre for Environmental Toxicology, Brisbane, Australia, November 15-19, 1999; San Juan, Puerto Rico NIEHS, Invited Participant Workshop Discussant, National Institute of Environmental Health Sciences. The Role of Human Exposure Assessment in the Prevention of Environmental Disease, September 22-24, 1999, Rockville, Maryland. Michigan State University, Invited Speaker Institute of Environmental Toxicology and Michigan Department of Community Health. October 26-27, Panel Discussant Arsenic: Health Effects, Mechanisms of Actions and Research Issues. Sponsored by N.C.I., N.I.E.H.S., and E.P.A. September 22-24, 1997, Maryland, U.S.A. Mexico City, Mexico; Invited Participant Reproductive Health and Environmental Factors Workshop for Identification of Priorities, sponsored by MacArthur Foundation. Mexico City, Mexico, June 9-10, Santiago, Chile; Participant Workshop on Sustainable Development in Urban Areas of the Americas, Risk Evaluation and Quantification session. Santiago, Chile, April 5-8, Santiago, Chile; Invited Lecturer Epidemiological investigation of population cancer risks. One week course, co-taught in Santiago, Chile, July 11-15, Co-sponsored by Instituto de Salud Pública, Universidad Católica and CORSAPS (Corporación de Salud y Políticas Sociales). University of California, Berkeley; Lecturer Lectures in courses Occupational Epidemiology and "Advanced Occupational and Environmental Epidemiology, School of Public Health, University of California, Berkeley

173 Other Appointments and Memberships Adjunct Professor, School of Public Health, University of North Carolina, Chapel Hill as doctoral dissertation committee member. Department of Epidemiology, Markey Cancer Center, University of Kentucky, Member since National Toxicology Program, Center for the Evaluation of Risks to Human Reproduction, Member of Expert Registry since Cardiovascular Health Coalition member, Kentucky. Migrant Network Coalition Member, Lexington, Kentucky. AWARDS IMPAC Award Journal of Registry Management Best Paper of the Year (2004) Graduate Minority Fellowship, University of California, Berkeley, Phi Beta Kappa, University of California, Berkeley, Golden Key National Honor Society, Cornell University Exchange Minority Summer Research Fellowship, Summer Regent Scholarship, University of California, Berkeley, JOURNAL PEER REVIEWER Archives of Environmental Contamination and Toxicology American Journal of Epidemiology Cancer Cancer Epidemiology, Biomarkers and Prevention Cancer Letters Chemosphere Environmental Health Perspectives Environmental Research Epidemiology International Journal of Epidemiology Journal of Registry Management Journal of Health, Population and Nutrition Journal of Health Care for the Poor and Underserved Journal of Asian Earth Sciences Public Health Science of the Total Environment PROFESSIONAL AFFILIATIONS American Public Health Association. Member since International Society for Environmental Epidemiology, Member since Kentucky Public Health Association, Member since Society for Epidemiologic Research. Member since LANGUAGES: Completely fluent in English & Spanish, knowledge of Portuguese and French. 19

174 STEVEN R. BROWNING, M.S.P.H., Ph.D. Department of Epidemiology, Suite 209 B College of Public Health University of Kentucky 121 Washington Ave Lexington, Kentucky Telephone: srbrown@ .uky.edu Current Position Education Assistant Professor of Epidemiology (August current) Department of Epidemiology College of Public Health The University of Kentucky Doctor of Philosophy, Department of Epidemiology (May 1994) School of Public Health, The University of North Carolina at Chapel Hill Minor: Environmental Sciences and Engineering Master of Science in Public Health, Department of Epidemiology (December 1989) School of Public Health, The University of North Carolina at Chapel Hill Bachelor of Science, Department of Biology, Magna Cum Laude (December 1986) The University of Utah, Salt Lake City, Utah Major: Genetics and Ecology Minor: Anthropology Previous Work Experience Senior Scientist (August 2005-August 2006) Center for Health Research and Rural Advocacy Geisinger Health System Danville, Pennsylvania Assistant Professor of Epidemiology (June 2001 July 2005) College of Nursing Chandler Medical Center The University of Kentucky

175 Research Assistant Professor of Epidemiology (September 1994-June 2001) Department of Preventive Medicine and Environmental Health and The Southeast Center for Agricultural Health and Injury Prevention Chandler Medical Center The University of Kentucky Research Scientist / Environmental Epidemiology (January 1994-September 1994) Bureau of Environmental and Occupational Epidemiology New York State Department of Health Albany, New York Recent Extramural Research. 1) Association of Maternal Child and Health Programs. Data mini-grant capacity building program. Training Workshop for MCH professional in Frankfort, Kentucky. ($5,000). ( 2007) 2) Assist 2010 Grant. Subcontract with St. Elizabeth s Hospital ($12,500 in 2008; under negotiation). Cardiovascular screening, health promotion, and evaluation. Past Extramural Research. 1) Children s Injuries on Kentucky Beef Cattle Farms. Funded by the National Institute of Occupational Safety and Health. Grant number: 1 R01 OHO / Primary Investigator. Period: 10/01/99-9/29/03. Total Costs: $518, ) Patterns of Incidence, Mortality, and treatment of Colorectal Cancer in the Appalachian region of Kentucky, Appalachian Cancer Network. National Cancer Institute. Primary Investigator. Total Costs: $49, 635 3) Asthma Among. Kentucky Farm Children. Primary Investigator. Southeast Center for Agricultural Health and Injury Prevention. NIOSH. Total Costs: $18, 104 4) Co-investigator (with Deborah Reed, Principal Investigator) Sustained Work Indicators of Older Farmers. CDC/NIOSH. Grant. Total Costs: $1,267,000 5) Co-investigator (with Robert McKnight) Farmer Suicides: A Ten Year Analysis in Three Southeastern States. Total Costs: $40, 792 (CDC/NIOSH) 6) Co-investigator, (with Debra Anderson, PI) Risk for Workplace Violence in Long- Haul Truckers. CDC/NIOSH. Total costs: $640,271

176 7) Chronic Arsenic Exposure from Drinking Water and Reproductive Effects (with Claudia Hopenhayn, PI). Funded by the Environmental Protection Agency. / Coprincipal investigator. Total Costs: $440,265. 8) Farm Family Health and Hazard Surveillance Project. Funded by the National Institute for Occupational Safety and Health / Co-investigator. Period: Total Costs: 9) Promoting ROPS and Seat Belt Use on Family Farm Tractors. Funded by the National Institute for Occupational Safety and Health / Co-investigator. Total Costs: $682, ) Agricultural Disability Awareness and Risk Education. Funded by the National Institute for Occupational Safety and Health / Co-investigator. Period 9/30/1997-9/29/2001. Total Costs: $588,830. Published Manuscripts 2007 Rugg, S., Bailey A. and Browning SR. Preventing Cardiovascular Disease in Kentucky: Epidemiology, Trends, and Strategies for the Future. (2007) (accepted by the Kentucky Medical Association Journal). Okoli, C.T.C., Browning, S., Rayens, M.K., Hahn, E.J. (2008). Secondhand tobacco smoke exposure, nicotine dependence, and smoking cessation. Public Health Nursing. 25(1): Reed, DB, Browning SR, Westneat SC, Kidd, PS. Personal Protective Equipment Use and Safety Behaviors Among Farm Adolescents: Gender Differences and Predictors of Work Practices. The Journal of Rural Health. Volume 22, Issue 4. Fall Pages Carruth, A, Browning SR, Reed DB, Skarke L, Sealey L., The impact of Farm Lifestyle and Health Characteristics. Cervical Cancer Screening Among Southern Farm Women. Nursing Research. January/February Vo. 55, Number

177 Bunn, TL, Slavovoa S, Struttman TW, Browning SR. Sleepiness/fatigue and distraction/inattention as factors for fatal versus nonfatal commercial motor vehicle driver injuries. Accid. Anal Prev. September 37(5) 862-9, Spengler, SE, Browning, SR, Reed DB. Sleep deprivation and Injuries in Part-Time Kentucky Farmers: Impact of Self-Reported Sleep Habits and Sleep Problems on Injury Risk. AAOHN Journal. Volume 52, Number 9, September Browning SR, Westneat SC, Donnelly C, and Reed DB. Agricultural Tasks and Injuries among Kentucky Farm Children: Results of the Farm Family Health and Hazard Surveillance Project. Southern Medicine, Volume 96, Number 12, December Hopenhayn-Rich C., Ferreccio C, Browning S., Wang, B, Peralta C., Gibb H. and Hertz- Picciotto I., Arsenic Exposure from Drinking Water and Birth Weight. Epidemiology. Volume 14, Number 5, September Hopenhayn-Rich C, Stump M, Browning S, Huang, B. (2002). Regional assessment of atrazine exposure and incidence of breast and ovarian cancers in Kentucky. Archives of Environmental Contamination and Toxicology. 42: Browning SR, Westneat SC, Szeluga R. (2001). Tractor Driving Among Kentucky Farm Youth: Results from the Farm Family Health and Hazard Surveillance Study. Journal of Agricultural Safety and Health. 7(3): Horstman SW, Browning SR, Szeluga R, Burzycki J, and Stebbins, A. (2001). Solvent Exposures in Screen Printing Shops. Journal of Environmental Science and Health, Part A Toxic and Hazardous Substances and Environmental Engineering. 36(10): Hopenhayn-Rich C., Browning S., Hertz-Picciotto I., Ferreccio C.,Peralta C. and Gibb H. Chronic Arsenic Exposure and Risk of Infant Mortality in Two Areas of Chile. Environmental Health Perspectives. July Vol. 108 ( 7) :

178 Piecoro L, Browning SR, Prince TS, Ranz, TT. Prevalence of Potentially Inappropriate Prescribing in the Elderly Kentucky Medicaid Population. Pharmacotherapy Feb;20 (2) : Cole H, Westneat S, Browning S, Piercy L, and Struttman T. Gender Differences in Principal Farm Operators Tractor Driving Safety Beliefs and Behaviors. Journal of American Medical Women s Association. Vol. 55, Number 2. Spring Prince TS, Heath R, Browning SR. Health Insurance and Work: Characteristics Among Multi-Job Holding Farmers. Journal of Agromedicine. Vol 7(2) 2000 Smalley BW, Loecker TH, Collins TR, Prince TS, and Browning SR. Positive Predictive Value of Cardiac Fluoroscopy in Asymptomatic U.S. Army Aviators. Aviation, Space, and Environmental Medicine. Vol 71, Number 12, December Browning SR, Westneat, SC, Truszczynska H, Reed D, McKnight R. Hazard Surveillance of Farm Tractor Safety Features: Results from the Kentucky Farm Family Health and Hazard Surveillance Project Public Health Reports. Vol. 114 ; January/February 1999 Heath R, Browning SR, Reed D. Prevalence and Risk Factors for Hypertension Among Older Kentucky Farmers. Journal of Agromedicine. Vol 6 (1) Hopenhayn-Rich C., Hertz-Picciotto I., Browning S., Ferreccio C., Reproductive and Developmental Effects Associated with Chronic Arsenic Exposure. Book Chapter. Proceedings of the 3 rd International Conference on Arsenic Exposure and Health Effects. August Reed D, Westneat S, Browning S, Skarke L. The Hidden Work of the Farm Homemaker. Journal of Agricultural Safety and Health Vol. 5 (3) p , Browning SR, Truszczynska H, Reed D, McKnight R. Agricultural Injuries Among Older Kentucky Farmers: The Farm Family Health and Hazard Surveillance Study. American Journal of Industrial Medicine Vol Loomis DP, Browning SR, Schenck AP, Savitz DA. Cancer Mortality Among Electric Utility Workers Exposed to Polychlorinated Biphenyls. Occupational and Environmental Medicine :

179 Kettles MA, Browning SR, Prince TS, Horstman SW. Triazine Herbicide Exposure and Breast Cancer Incidence: An Ecologic Study of Kentucky Counties. Environmental Health Perspectives. Vol. 105 Strogatz D., Croft J, James S, Keenan N, Browning SR, Garrett J. Social support, stress, and blood pressure in blacks. Epidemiology. September Vol. 8, Number Loomis DP, Peipins LA, Browning SR, Howard RL, and Savitz DA. Organization and classification of work history data industry-wide studies: an application to the electric power industry. American Journal of Industrial Medicine, 26: , 1994 James SA, Keenan NL, Strogatz DS, Browning SR, Garrett JM. Socioeconomic status, John Henryism, and blood pressure in Black adults: The Pitt County Study. American Journal of Epidemiology, 1992; 135(1): Strogatz DS, James SA, Haines PS, Elmer PJ, Gerber AM, Browning SR, Ammerman AS, Keenan NL. Alcohol consumption and blood pressure in Black adults: The Pitt County Study. American Journal of Epidemiology, 1991; 133: James SA, Keenan NL, and Browning SR. Socioeconomic status, health behaviors, and health status among Blacks. In D. Blazer, J. House and W. Schaie (eds.), Aging, Health Behaviors, and Health, Hillsdale, NJ: Erlbaum, 1990 Other Published Works. Struttman T, Spurlock C, Browning S, McKnight R. Farm Tractor Related Fatalities in Kentucky, Morbidity and Mortality Weekly Report (MMWR), Vol 44, Number 26, July 7, 1995 Zwerling, C et al including S. Browning. Use of Rollover Protective Structures -- Iowa, Kentucky, New York, and Ohio, Morbidity and Mortality Weekly Report (MMWR), Vol. 46, Number 36. Browning, SR; Westneat SC, Reed DB, McKnight, RC. The Kentucky Farm Family Health and Hazard Surveillance Project: Final Report: Sampling, Data Analysis, and Selected Results. Prepared for the National Institute of Occupational Safety and Health. Submitted January Manuscripts Accepted, Submitted or In Progress. Browning S, Westneat S, Reed D, and Omerod K. Farm Injuries in a Prospective Cohort of Older Farmers in Kentucky and South Carolina. (To be submitted to the American Journal of Industrial Medicine, 2008).

180 Fahrleitner-Palmer, A. Herberth J, Browning S, Obermayer-Pietsch B, Wirnsberger G, Holzer H, Malluche H. Noninvasive markers of bone metabolism predict cardiovascular morbidity and mortality in chronic kidney disease. (To be submitted to the New England Journal of Medicine, 2007). Browning SR, Westneat SC, and McKnight R. Suicide Mortality in Farmers in Three Southeastern States. (2007) ( submitted to the Journal of Agricultural Safety and health) Heaton K., Browning SR, Anderson D. Variables that predict falling asleep at the wheel in long haul truck drivers (2007) (Submitted to AAOHN journal) Browning SR, Westneat SC, and Szeluga R. Children s Injuries on Kentucky Beef Cattle Farms. A Final Report for Grant 1 R01 OHO (August 2004) Browning SR, Westneat SC. Farm Work and Agricultural Exposures among Children on Kentucky Beef Cattle Farms: Results from a Cohort Study. (in preparation for the Journal of Agricultural Safety and Health). Browning SR, Szeluga R. Cattle-related Injuries and Farm Management Practices on Kentucky Beef Cattle Farms. (in preparation for the American Journal of Industrial Medicine). Reed D, Browning SR, Westneat SC. Self-reported Farm Work Exposure, Protective Measures, and Injuries of Farm Teens in Three States. (submitted to the National Institute of Farm Safety (NIFS)). Texbook Chapter. Cardiovascular Epidemiology. Browning SR and Fleming S. To be published in Managerial Epidemiology by Steven Fleming et. al. ( ) Abstracts (2007) Fahrleitner-Pammer A, Herberth J, Browning SR, Holzauer H, Malluche HH. Noninvasive markers of bone metabolism predict cardiovascular morbidity and mortality in chronic kidney disease. 40 th Annual Meeting, American Society of Nephrology, San Francisco, CA Burkhart, P.V., Browning, S.R., Westneat, S., Knox, C., & Abshire, D. (2007). Respiratory health of Kentucky farm children. The Journal of Allergy and Clinical Immunology, 119(1), S68. Abstracts/Presentations. ( )

181 2004. Browning SR, Westneat SC, Davis R. Work Exposures and Risk of Cattle-Related Injuries On Kentucky Beef Cattle Farms. Canadian Agricultural Safety Association Conference. Quebec, Canada. December 3-5, McKnight RH, Browning SR, Westneat SC. Suicide Among Older Kentucky Farmers, Italian Occupational Gerontology meeting. October, Bunn, TL, Kurpad, A., Struttmann, T.W., Browning, SR, Caldwell, GG. Driver Distraction/Inattention And Driver Fatigue As Risk Factors For A Fatal Commercial Vehicle Collision In Kentucky Presented for National Occupational Injury Symposium in Pittsburgh in October Browning SR, Westneat SC, Szeluga R. Farm Work and Agricultural Exposures Among Children on Kentucky Beef Cattle Farms. (abstract published in Epidemiology, July 2002, Volume 13, Number 4, Supplement). Presented at the ISEA/ISEE International meeting. International Society for Environmental Epidemiology. Vancouver, British Columbia, Canada. August Szeluga R, Browning S. Westneat S. Farm management practices, work exposures and risk of cattle-related injuries on Kentucky beef cattle farms. Agromedicine Conference. San Diego, California. November Hopenhayn-Rich C, Browning SR, Ferreccio C, Huang B, Peralta C, Hertz-Picciotto I, Gomez-Caminero, A, Gibb H. The Effects of Arsenic in Drinking Water on Birth Weight. To be presented at the International Society for Environmental Epidemiology meeting in Garmisch-Partenkirchen, September 2-5, Hopenhayn-Rich C, Stump M, Browning S, Huang B. Use of secondary data to characterize exposure to environmental pollutants in drinking water, To be presented at the International Society for Environmental Epidemiology meeting in Garmisch- Partenkirchen, September 2-5, Browning S, Westneat SC, Szeluga R. Farm work injuries to children on Kentucky beef cattle farms. Presentation at the National Occupational Injury Research Symposium. Pittsburgh, PA. October 17-19, 2000.

182 Browning S, Westneat SC, Szeluga R. Health status and maternal education as predictors of the usual number of days worked for Kentucky Farm Children. Presented at Agricultural Safety and Health in the New Century. April 28-30, Cooperstown, New York. Stump M, Hopenhayn-Rich C, Browning S. Atrazine and Risk of Ovarian Cancer. Presented at Agricultural Safety and Health in the New Century. April 28-30, Cooperstown, New York. Clouse R, Browning S, Reed D, Horstman S. Dust Exposure and Risk of Respiratory Disease among Tobacco Strippers. Poster presented at Agricultural Safety and Health in the New Century. April 28-30, Cooperstown, New York. Hopenhayn-Rich C, Ferreccio C, Peralta C, Browning S, Huang B, Gomez-Caminero A, Hertz-Picciotto I, Gibb, H. Arsenic exposure from drinking water and reproductive effects: pregnancy cohort study in Chile. Presented at the 6th International Symposium of Metal Ions in Biology and Medicine, San Juan, Puerto Rico, May Hopenhayn-Rich C, Peralta C, Browning SR, Huang B, Ferreccio C, Gomez-Caminero A, Hertz-Picciotto I. Arsenic exposure and reproductive outcomes: Preliminary report from a pregnancy cohort study in Chile. Presented at the Fourth International Conference on Arsenic Exposure and Health Effects, San Diego, California, June, Cole H, McKnight R, Reed D, Browning S, Struttman T, Piercy L. Probability of Death During a Farm Tractor Overturn. Presentation given by S. Browning at the National Occupational Injury Research Symposium. October 17-19, Hopenhayn-Rich C, Ferreccio C, Hertz-Picciotta I, Peralta C, Browning S, Gibb H. Prospective Pregnancy Followup Study and Arsenic Exposure. (abstract published in Epidemiology July 1999: Volume 10, Number 4 Supplement) 1998 (First author) Browning SR, Westneat SC, Reed DB, Skarke L. The Health of Kentucky Farm Women. Women s Health Conference. September 25-26, Somerset, Kentucky. Browning SR, Reed DB, McKnight, RH. Prevalence and Risk Factors for Arthritis among Older Kentucky Farmers. Fourth International Symposium: Rural Health and Safety in a Changing World. October Saskatoon, Saskatchewan, Canada (other authorship)

183 Piecoro LP, Browning SR, Prince TS, Ranz TT, Scutchfield FD. Prevalence of Potentially Inappropriate Medication Prescribing in the Elderly Kentucky Medicaid Population. American Public Health Conference. Washington, DC. November 21, Westneat SC, Browning SR, Reed DB. Tractor Driving among Kentucky Farm Youth. Fourth International Symposium: Rural Health and Safety in a Changing World. October Saskatoon, Saskatchewan, Canada. Cole HP, Westneat SC, Browning SR, Piercy LR. Gender differences in principal farm operators beliefs and practices related to ROPS and seatbelts. Fourth International Symposium: Rural Health and Safety in a Changing World. October Saskatoon, Saskatchewan, Canada (First author) Browning SR, Westneat SC, Luchok K, and Wendt C. Skin Cancer Prevention Practices Among Kentucky Farm Women. Presented at the American Public Health Association conference. November 9-13, Browning SR, Westneat SC, Reed DB, Skarke L. Women in the Fields: A comparison of injuries in Kentucky and Texas. National Occupational Injury Research Symposium. Morgantown, West Virginia. October, Browning SR, Westneat SC, McKnight RH. Work tasks, Days worked, Supervision, and Risk of a Farm-related Injury Among Kentucky Farm Children. Agricultural Health and Safety Conference. Morgantown, West Virginia Browning SR, Westneat SC, Reed DB, McKnight, RH. Hazard Surveillance among Kentucky Farm Children: Results from the Farm Family Health and Hazard Surveillance Study. Agricultural Health and Safety Conference. Morgantown, West Virginia. July 15-17, (award winning) Browning SR, Truszczynska H, McKnight R, Reed D. Hazard Surveillance of Farm Tractor Safety Features. Poster presented at the American Industrial Hygiene Conference and Exposition. May 17-23, Dallas, Texas Browning SR, Westneat SC, McKnight R. Hazardous Work and Injuries among Kentucky Farm Children. Poster presented at Prevention 97. February, 1997, Atlanta, Georgia. (award winning) 1997 (Other authorship)

184 TS Prince, SR Browning. Risk factors for lack of health insurance among farmers holding multiple jobs in Kentucky. Poster presentation at the American Public Health Association Annual meeting. Indianapolis, IN Nov , Webber WB, Browning SR. Exposure to pesticides and skin cancer among older Kentucky Farmers. Poster presentation at the American Public Health Association Annual meeting. Indianapolis, IN Nov , Heath RL, Browning SR, Reed DB. Hypertension prevalence among older Kentucky farmers. Poster presentation at the American Public Health Association Annual meeting. Indianapolis, IN Nov , Webber WB, Browning SR. Exposure to pesticides and skin cancer among older Kentucky Farmers. Poster presentation at the 13th Congress of the International Association of Agricultural Medicine and Rural Health. Iowa City, Iowa. September 7-9, Reed DB, Browning SR, Westneat SC. Mammography use patterns in two states. Presented at Agricultural Health and Safety Conference. Morgantown, West Virginia. July 15-17, (First author) Browning SR, Trusczcynska H, McKnight R. Agricultural Injuries Among Older Kentucky Farmers. Annual meeting of the Society of Epidemiologic Research. Boston, Massachusetts. June (Other authorship) McKnight RH, Browning SR, Reed DB. Survivors of farm tractor overturn: a profile from Kentucky, USA. Presented at the Third International Conference of Injury Prevention and Control. February 18-22, Melbourne, Australia. McKnight RH, Browning SR. Prevalence of traumatic amputations in older farmers: Results of injury surveillance in Kentucky. 25th Annual International Congress on Occupational Health. Stockholm, Sweden, September (First author) Browning, SR, Reed DB, and McKnight RH. Back pain in older Kentucky Farmers. Poster presented at the American Public Health Association Annual meeting in San Diego, California. October 29- November 2, (Other authorship)

185 Loomis DP, Browning SR, Savitz DA, Schenck AP, and Gregory E. Cancer Mortality and Exposure to Polychlorinated Biphenyls Among Electric Power Workers in the USA. Presented at the 11 International Symposium of Epidemiology in Occupational Health. Noordwijkerhout, The Netherlands. September 5-8, Reed DB, Browning SR, and McKnight RH. Hearing Loss Among Older Kentucky Farmers: An Occupational Risk. Presented at the American Public Health Association Annual meeting. San Diegor, California. October 29-November 2, McKnight RH, Browning SR, Reed DB. Are Children working on their family s farm protected by rollover protection on tractors? Presented at the American Public Health Association Annual meeting. San Diego, California. October 29-November 2, McKnight RH, Reed DB, and Browning SR. Farm Children at Work: On and Off the Farm. Child and Adolescent Rural Injury Control Conference. Middleton, Wisconsin. March 8-9, Seminars. Browning SR. PCB Exposure and Cancer Mortality in Electric Utility Workers. April 27, 1998 Graduate Center for Toxicology Seminar. The University of Kentucky. Browning SR. The Health Effects of PCB Exposure. Seminar for Residents in Preventive and Occupational Medicine. May 24, The University of Kentucky. Dissertation and Thesis. Browning SR. Polychlorinated biphenyl exposure and cancer mortality in electric utility workers. PhD dissertation. Department of Epidemiology. The University of North Carolina at Chapel Hill. Chapel Hill, NC (May 1994) Browning SR. Occupational stress and hypertension among Blacks in the Pitt County Hypertension Project: Job future ambiguity and hypertension. Unpublished master s thesis. Department of Epidemiology. The University of North Carolina at Chapel Hill. Chapel Hill, NC (December 1989) Teaching and Advising. College of Public Health (CPH712/910). Advanced Epidemiology. Fall 2006, Fall 2007, Spring College of Public Health (CPH ) Cardiovascular Epidemiology. Spring 2007.

186 College of Nursing (NUR 904) Epidemiology Applied to the Design and Evaluation of Nursing and Health Services: A Distributed Learning Class. (3 credits) Fall College of Nursing (NUR 794): Analysis, Interpretation, and Presentation of Quantitative Data. (3 credits) Spring 2002 Preventive Medicine (PM) 521: Introduction to Epidemiology (4 credits). Co-instructor Primary Instructor Preventive Medicine (PM) 621: Advanced Topics in Epidemiology (2 credits). Primary Instructor Environmental Systems 620: Guest Lecturer (1) 3-hour lecture per semester. Principles of Environmental Epidemiology: The PCB Story Healthy Human Course: Guest Lecturer (2) 2 hour lectures per semester. Basics of Clinical Epidemiology / Screening for the Physician Research Methods. Guest lecture (1) 3 hour lecture per semester. Methodologic Issues in Injury Epidemiology. Student accomplishments (Advisor). Jessica Wilson, Doctoral Student in Nursing.25,000 grant from the Southeast Center for Agricultural Health and Injury Prevention. Johann Herberth, MPH student and Physician in the Division of Nephrology, University of Kentucky. University of Kentucky, Dean s Clinical Scholars Program, ID no , PI J Herberth, MD Project: Replacement of Bone Biopsy by noninvasive markers in chronic kidney disease Professional Societies. American Public Health Association member Society of Epidemiologic Research member Professional Service. Reviewer for CDC grant review panel (July 2007) Reviewer for the American Journal of Industrial Medicine Reviewer for the Journal of Agricultural Safety and Health Reviewer for American Journal of Public Health. Grant reviewer for the Alberta Heritage Foundation for Medical Research

187 Grant Review: Review Panel for RFA OH Community Based Interventions to Prevent Childhood Agricultural Injury and Disease. (Washington, DC, May 15-16, 2001) Invited Participant: 2001 Summit on Childhood Agricultural Injury Prevention (Brooklyn Park, MN ; April 30 May 1, 2001) Academic Committees Academic Affairs Committee. College of Public Health. Admissions Committee. College of Public Health. Committee on Research and Policy of the Kentucky Water Resources Institute, University of Kentucky. Faculty Council, College of Nursing, (Chair in ) College of Nursing Strategic Planning Committee Training Conferences and Workshops Attended. Cancer Surveillance Institute I. Principles and Public Health Applications. January 28-31, San Jose, California. Southeast SAS Users conference. July 2003 Sample size analysis workshop. Southeast SAS Users group. Jacksonville, Florida. September, Calculation methods for Industrial Hygiene. Professional Development Course. American Industrial Hygiene Conference. May Dallas, Texas. NIH Regional Seminar on Program Funding and Grants Administration. Vanderbilt University. Nashville, TN (September 4-5, 1997) SUDAAN Training course. Analysis of statistical data from complex sample surveys. The University of Maryland. January Histopathobiology of Neoplasia. The Edward A. Smuckler Memorial Workshop. The Keystone Colorado Conference Center. Keystone, Colorado. June 23-30, Awards.

188 1. National Research Service Award, Cancer Training Grant ( ) 2. Public Health Service Traineeship ( ) 3. Delta Omega Honorary Public Health Society (1995) 4. Student Member of the Institutional Review Board for Human Subjects Research, School of Public Health, The University of North Carolina at Chapel Hill ( ) 5. Student Honoree, Department of Epidemiology, School of Public Health Alumni Conference (1991)

189 STEVEN T. FLEMING 213C College of Public Health Building 121 Washington Avenue Department of Epidemiology University of Kentucky Lexington, Kentucky (859) FAX (859) EDUCATION University of Michigan, Ph.D. in Health Services Organization and Policy, dissertation: "Toward an understanding of the relationship between the quality and cost of hospital care" University of Michigan, A.M. in Applied Economics University of Hartford, M.P.A. with a major in Health Administration Rutgers University, B.S. in Environmental Sciences MILITARY Certificate (1972) from U.S.A.F. School of Aerospace Medicine: San Antonio, Texas. Member of the Connecticut Air National Guard ( ). EMPLOYMENT EXPERIENCE (ACADEMIC SETTING) Visiting Research Fellow, Centre for Public Health Research, Queensland University of Technology, Kelvin Grove, Queensland, Australia Associate Professor with tenure (March 1998) of Epidemiology, The University of Kentucky: Lexington, Kentucky Assistant Professor of Health Services Management, The University of Missouri-Columbia: Columbia, Missouri Assistant Professor of Health Services Administration, Quinnipiac College: Hamden, Connecticut, Acting Director, Instructor of Health Services Administration, Quinnipiac College: Hamden, Connecticut EMPLOYMENT EXPERIENCE (OTHER SETTINGS) Faculty for Executive Program in Managed Care for the National Center for Managed Health Care Administration: Kansas City, Missouri

190 Research Associate II in the Department of Research Services, The Commission on Professional and Hospital Activities: Ann Arbor, Michigan Research Associate in the Department of Research Services, The Commission on Professional and Hospital Activities: Ann Arbor, Michigan Research Assistant in the Department of Research Services, The Commission on Professional and Hospital Activities: Ann Arbor, Michigan Part-time Research Assistant in the Department of Medical Care Organization, The University of Michigan: Ann Arbor, Michigan Research Assistant in the Departments of Biochemistry and Medicine, University of Connecticut Health Center: Farmington, Connecticut Laboratory Technician in the Isotope Laboratory, St. Francis Hospital: Hartford, Connecticut GRADUATE TEACHING EXPERIENCE Introduction to the Health Care System Managerial Epidemiology Introduction to Epidemiology Advanced Epidemiology Research Methods Decision making in Health and Medicine Epidemiology Applied to the Design and Evaluation of Nursing and Health Services Managerial Epidemiology (Zayed University, United Arab Emirates) Cancer Epidemiology 1999 Member: PhD Dissertation Committee, Matthias Akomaye Udie, The effect of market structure on the stage of breast cancer diagnosis for Medicare HMO enrollees Member: PhD Dissertation Committee, Terry Wiant, Policy and its impact on medical record security Member: MPH capstone Committee, Brian Dean, A question of access: comparing barriers to oral health services between nursing home residents and well-elders in Kentucky Chair: MPH capstone Committee, John M Bennett, Improving compliance for colon cancer screening through education outreach and a practice based intervention Chair: MPH capstone Committee, Rishika Basappa, Continuity of patient care and tobacco cessation counseling Chair: MPH Capstone Committee, Mef D. Galle, Impact of antimicrobial control program on the incidence of candidemia in a university affliliated hospital Member: MPH Capstone Committee, Xuejing Wang, The effect of folic acid based supplements on lowering blood homocysteine : meta analysis of randomized trials Co-chair: MPH Capstone Committee, Amber Bryn Riba, West Virginia laboratory capacity for Hepatitis C virus testing: an evaluation of adherence to the Centers for Disease Control and Prevention guidelines Member: MPH Capstone Committee, Cheryl Leanne Ashby, Association of patient age and body mass index with delivery of preconception and sexual health counseling to adolescent females.

191 2004 Member: MPH Capstone Committee, Mehjabeen Chowdjury, Fayette county eating establishment smoking policy survey Member: MPH Capstone Committee, Laura Elizabeth Hackett, The epidemiology of West Nile virus in the commonwealth of Kentucky Member: MPH Capstone Committee, Rondeen Gordon. Is Suicide More Likely in Older Adults with a Chronic Disease or Mental Illness? 2004 Member: MPH Capstone Committee, Shulin Dong. The role of radiotherapy in improving survival in patients with small cell lung cancer Member: MPH Capstone Committee, Brandon Hurley Member: MPH Capstone Committee, William Porter, Attending physicians perceptions of computerized physician order entry (CPOE) implementation Member: MPH Capstone Committee, January Breeden. The relationship between clinician diagnoses and clinician perceived depression and anxiety in community primary care practice 2005 Member: MPH Capstone Committee, Jennifer Rene Olges, A survey of Kentucky prenatal care provider testing practices and knowledge of human immunodeficiency virus Chair: MPH Capstone Committee, Rafael Rangel, Pregnancy prevention in Pike county: a focus on teenage males Member: MPH Capstone Committee, Jessica Berres Houlihan, Determination of risk factors for developing community-acquired pneumonia in HIV/AIDS papients since the era of HAART 2006 Outside Member: PhD Dissertation Committee, Theodore Wesley Randall Jr. Malaria Etiology, Prevention, and Treatment in the Gambia Member: MPH Capstone Committee, Yvonne Konner. Public Health Approach to Overweight and Obesity: An Evaluation of Formal Weight Loss Programs here at the University of Kentucky (The Health and Wellness Weight Loss Matters and BeHIP s Weight Loss for Life Programs) 2006 Member: MPH Capstone Committee, Donald J. Covell, Assessing the Influence of Non- Clinical Factors on Brain Cancer Treatment Member: MPH Capstone Committee, Elizabeth L. Stevie, Obtaining Mammography Screening in Three Kentucky Primary Care Clinics Member: MPH Capstone Committee, Richard Meir, Predictors of Poor Outcomes of Uveitis Associated with Juvenile Idiopathic Arthritis Co-Chair: MPH Capstone Committee, Frank Rominelli, Risk Factors for Community Acquired Methicillin Resistant Staphylococcal Aureus (cmrsa) Among a Mixed Urban- Rural HIV Infected Population Member: MPH Capstone Committee, Justin L. Blackburn, Changes in Clinical Health Indicators in a Cohort of Australian Farm Families Member: PhD Dissertation Committee, Lynne Jensen, "Cognitive and Psychological Factors That Influence Outcomes in Coronary Heart Disease Patients" 2007 Chair: MPH Capstone Committee, Erin Miller Reid, Sociodemographic Risk Factors Associated with the Late-Stage Diagnosis of Colorectal Cancer Chair, MPH Capstone Committee, Andrew Kinch. Kentucky's Male HIV/AIDS Population: the Challenge Facing a Predominantly Rural State Member, MPH Capstone Committee Maya McDoom. Patient and Caregiver Evaluation in a Hospice Setting Utilizing the Social Worker Assessment Tool Member, DrPH Capstone Committee, Carol Mclay. A Prolonged Outbreak of Day-Care Associated Shigella Sonnei: A Case-Control Study Member, MPH Capstone Committee, Dana Hazen. Gender Specific Differences in the Pros and Cons of Smoking among Current Smokers in Eastern Kentucky.

192 2007 Member, MPH Capstone Committee, Amanda Wilburn. Hepatitis C Infection in Three Eastern Kentucky Counties: Risk Factors and Predictors. COMMITTEES 2003 Member: Six-year Review Committee for UK Center for Health Services Management and Research Chair: Appointment, Promotion, and Tenure Committee, College of Public Health Member: Faculty Council, College of Public Health Member: Service Committee, College of Public Health 2005 Academic Council of the Medical Center Review Committee Cancer Prevention and Control Program Scientific Advisory Committee Member: Research Committee, College of Public Health PUBLICATIONS Killip S, Ireson CL, Love MM, Fleming ST, Katirai W, Sandford K Patient Safety in After-hours Telephone Medicine. Family Medicine Journal 39(6): Schoenberg NE, Kim H, Edwards W. Fleming ST The burden of common multiple morbidity constellations on out-of-pocket medical expenditures among older adults. The Gerontologist. 47(4): Fleming ST. Data Sources for Measuring Comorbidity: Response to Klabunde et al, October 2006 Medical Care. Medical Care. 45(3): 274. Fleming, S.T., McDavid, K., Pearce, K., and Pavlov, D. (2006) Comorbidities and the risk of late-stage prostate cancer. TSW Urology 1, DOI /tswurol Fleming ST, Pursley HG, Newman B, Pavlov D, Chen K Comorbidity as a predictor of stage of illness for patients with breast cancer. Medical Care 43(2): Fleming ST, Pearce KA, McDavid K, Pavlov D The development and validation of a comorbidity index for prostate cancer among Black men. Journal of Clinical Epidemiology. 56(11): Beaulieu J, Galland J, Fleming S, Chen K, Peng Xuejun Geographic variation in breast-conserving surgery in Kentucky s Medicare population J Kentucky Medical Association 100: Fleming, ST, Scutchfield, FD, Tucker, TC Managerial Epidemiology, Chicago: Health Administration Press, 277 pages. Fleming, ST, Dmitrienko A, Rastogi A A Comprehensive Prognostic Index to predict mortality based on multiple comorbidities: A Focus on Breast Cancer. Medical Care. 37(6): Fleming ST. and Kohrs, FP. (1998). Linking claims data and cancer registry data: is it worth the effort? Clinical Performance and Quality Health Care, 6(2):

193 Boles KE and Fleming ST (1997) Why traditional breakeven analysis doesn t work with managed care, Health Care Systems Economics Report, 1(9): Fleming ST. (1996). Complications, adverse events, and iatrogenesis: classifications and quality of care measurement issues, Clinical Performance and Quality Health Care, 4(3): Boles KE and Fleming ST. (1996). Breakeven under capitation.: pure and simple? Health Care Management Review, 21(1): Fleming ST. (1995). Multiple Sclerosis as a comorbidity: a study of resource utilization and outcomes of care. Clinical Performance and Quality Health Care, 3(1): Fleming ST, Williamson H, Hicks L, Rife I. (1995). Rural hospital closures and access to services, Hospital & Health Services Administration, 40(2): Fleming ST. (1995). Primary care, avoidable hospitalization, and outcomes of care: a literature review and methodological approach., Medical Care Research and Review, 52(1): Fleming ST, Hicks L, Bailey RC. (1995) Interpreting the Health Care Financing Administration mortality statistics, Medical Care, 33(2): Fleming ST, Blake R. (1994). Patterns of comorbidity in elderly patients with multiple sclerosis. Journal of Clinical Epidemiology, 47(10): Fleming ST and Boles KE. (1994). Financial and clinical performance: bridging the gap. Health Care Management Review, 19(1): Long MJ, Fleming ST, Chesney, JD. (1993). The impact of diagnosis related group profitability on the skimming and dumping of psychiatric DRGs. International Journal of Social Psychiatry, 39(2): Long MJ, Chesney JD, Fleming ST. (1993). Profitable and unprofitable DRGs: the implications for access. Health Services Management Research, 6(1): Fleming ST, Bopp KD, Anderson KG. (1993). Spreading the good news of total quality management: faith, conversion, and commitment. Health Care Management Review, 18(4): Fleming ST. (1992). Outcomes of care for anesthesia services: a pilot study. Quality Assurance in Health Care, 4(4): Fleming ST. (1992). Toward the development of integrative risk-adjusted measures of quality using large clinical databases: the case of anesthesia services. Evaluation & the Health Professions, 15(1): DesHarnais S, Hogan AJ, McMahon LF, Fleming S. (1991). Changes in rates of unscheduled hospital readmissions, and changes in efficiency following the introduction of the Medicare Prospective Payment System: an analysis using risk-adjusted data. Evaluation & The Health Professions. 14(2): Fleming ST. (1991). The relationship between quality and cost:pure and simple? Inquiry, 28(1):

194 [The August 5,1991 issue of U.S. News and World Report made reference to the results of this study.] Fleming ST et al. (1991). The measurement of mortality: a risk-adjusted variable time window approach. Medical Care, 29(9): Long MJ, Chesney JD, Fleming ST. (1990). A reassessment of hospital product and productivity changes over time. Health Care Financing Review, 11(4): Fleming ST. (1990). The relationship between the cost and quality of hospital care: a review of the literature. Medical Care Review, 47(4): Long MJ, Chesney JD, Fleming ST. (1989). Were hospitals selective in their product and productivity changes: the top 50 DRG's after PPS. Health Services Research, 24(5): DesHarnais SI, Chesney JD, Wroblewski RT, Fleming ST, McMahon LF. (1988). The risk adjusted mortality index: a new measure of hospital performance. Medical Care, 26(12): DesHarnais SI, Chesney JD, Fleming ST. (1988). Trends and regional variations in hospital utilization and quality during the first two years of the Prospective Payment System. Inquiry, 25(3): DesHarnais SI, Chesney JD, Fleming ST. (1988). Should DRG assignment be based on age? Medical Care, 26(2): DesHarnais S, Kobrinski E, Chesney J, Long M, Ament R, Fleming S. (1987). The impact of PPS on inpatient utilization and the quality of care: the early effects. Inquiry, 24(1):7-16. Long MJ, Ament RP, Chesney JD, DesHarnais SI, Fleming ST, Kobrinski EJ, Marshall BS. (1987). The effect of PPS on hospital product and productivity. Medical Care, 25(6): Fleming ST, Kobrinski EJ, Long MJ. (1985). Multidimensional analysis of the impact of high-cost hospitalization. Inquiry, 22(2): PRESENTATIONS/POSTERS INTERNATIONAL Fleming ST, Newman B, Purlsey HG, Chen K, Pavlov D. Measuring Comorbidity Burden to Predict Stage of Illness in Breast Cancer Patients in the United States. Cancer Council of Victoria and University of Melbourne. Melbourne, Victoria. March 21, Fleming ST, Purlsey HG, Chen K, Pavlov D. Modelling Comorbidity Burden as a Predictor of Stage using the SEER Cancer Registry Linked to Medicare Insurance Claims. The Cancer Council of New South Wales. Sydney, New South Wales, Australia. January 23, Fleming ST, Purlsey HG, Chen K, Pavlov D. Comorbidity Burden and Stage at Diagnosis for Breast Cancer. ChristChurch School of Medicine, Christchurch, New Zealand. November 24, Fleming ST, Purlsey HG, Pearce K, McDavid K, Chen K, Pavlov D. Comorbidity Burden and Stage at Diagnosis for Breast and Prostate Cancer. Queensland Institute for Medical Research. Brisbane,

195 Queensland, Australia. October 30, Fleming ST. Managerial Epidemiology: the Case for Evidence-Based Management. Australian College of Health Service Executives (Qld) & The Queensland Centre for Public Health. Brisbane, Queensland, Australia. September 13, Fleming ST. McDavid KA. Pearce KA. Pavlov D. A Comorbidity Index Specific to Black Men with Prostrate Cancer (Poster). Congress of Epidemiology Toronto, Canada. June 13-16, Fleming ST. Casemix, Resource Utilization and Outcomes of Hospitalizations for MS Patients: A Case- Control Study. presented at the Eighth Annual Consortium Conference of the Consortium of Multiple Sclerosis Centers. Victoria, British Columbia. September 11-13, Fleming, ST. et al. Anesthesia-Related Outcomes: A Pilot Study. presented by S. Fleming at the International Society for Quality Assurance 8th International Symposium. Washington D.C. May PRESENTATIONS/POSTERS NATIONAL Killip S, Ireson C, Love M, Fleming S, Katirai W, McLay C. Patient Safety in Telephone Medicine. North American Primary Care Research Group Annual Meeting, Quebec City, Quebec Canada October Fleming, ST, Pursley, HG. Comorbidities, Race, and Stage of Breast Cancer. 37th Annual Meeting Society for Epidemiologic Research, June 15-18, 2004, Salt Lake City, Utah. Fleming, ST, Pursley HE, Newman B, Pavlov D, Chen K. Comorbidity as a Predictor of Stage of Illness for Breast Cancer Patients. American Public Health Association 131 st Annual Meeting, November 2003, San Francisco, CA Fleming, ST, Pursley HE, Newman B, Pavlov D, Chen K. Comorbidity as a Predictor of Stage of Illness for Breast Cancer Patients. AcademyHealth Annual Meeting, Poster Session June 2003, Nashville, TN. Fleming, Steven, Kathleen McDavid, Kevin Pearce, Dmitri Pavlov. Predictors of Treatment for Black and White men at least 67 years old with prostate cancer. American College of Epidemiology Annual Meeting Poster Session Sept 23, Albuquerque, NM. Fleming ST, Hicks L, Bailey C. Toward an Understanding of the Health Care Financing Administration Mortality Methodology: A case Study. presented at the 11th Annual Meeting of the Association for Health Services Research. San Diego, CA. June 12-14, Boles, KE and Fleming, ST. Financial and Clinical Performance: Bridging the Gap. presented by K. Boles at the 1992 Annual Meeting of the Association for University Programs in Health Administration. Washington, D.C. March 19-22, Fleming ST. The Risk-Adjusted Mortality Index: Some Enhancement. Poster Session at the 118th Annual meeting of the American Public Health Association. New York, New York. September 30 - October 4, Long MJ, Fleming ST, Chesney JD. The Impact of DRG Profitability on the Skimming and Dumping of

196 Psychiatric DRGs. presented by M. Long at the 1990 annual meeting of the Association of University Programs in Health Administration, Chicago, Illinois. Long MJ, Chesney JD, Fleming ST. Skimming Profitable and Dumping Unprofitable DRGs. presented by M. Long at the 117th Annual Meeting of the American Public Health Association, Chicago, Illinois, October 22-26,1989. Fleming ST. A Hospital Variable Cost Function that Measures Product Differentiation on the Basis of Quality. presented at the 64th Annual Western Economic Association meetings, Lake Tahoe, Nevada, June 18-22, RESEARCH AND PROFESSIONAL ACTIVITIES Centers for Disease Control and Prevention, Principal Investigator, Breast and Prostate Cancer Patterns of Care in Kentucky. $655,789. Agency for Health Care Policy & Research, Principal Investigator. Kentucky HSR Development (BRIC) II. $570,000. Agency for Health Care Policy & Research, Principal Investigator ( ). Kentucky HSR Development (BRIC). $388,998. ATPM/CDC/ATSDR, Principal Investigator. Comorbidities and Prostate Cancer in Elderly Black Men. $106,449. National Cancer Institute, Principal Investigator. The Comorbidity Factor and Breast Cancer. $98,498. University of Kentucky Medical Center Research Fund, Principal Investigator. The Comorbidity Factor in Elderly Breast Cancer Patients in Kentucky. $10,000. American Cancer Society Institutional Research Grant, Principal Investigator. The Costs and Outcomes of Breast Cancer: Merging Claims and Registry Data. $10,000. Social Services Financing grant, Office of International Affairs, 3/16/96-4/6/96. Taught an overview of the U.S. health care system, financing arrangements in healthcare, and cost-effectiveness analysis to a small delegation of Russians. Management of Rural Social Services and Rural Community Development grant, Office of International Affairs, 10/30/95-11/17/95. Taught an overview of the U.S. health care system, total quality management, and decision theory to a delegation of 13 Russians. Osteopathic Hospital of Texas, : Consultant with Lanis Hicks, analysis of the 1990 Medicare Hospital Mortality Report Department of Family and Community Medicine, 1992: Principal Investigator, small seed money grant to study rural hospital closures and access to care. (<$1000) National Multiple Sclerosis Society, : Principal Investigator. Comparative Analysis of Multiple Sclerosis Patients to Other Hospitalized Patients. $19997

197 Missouri Health Care Association, May 1992, four hour seminar with Keith Boles, Total Quality Management in Nursing Home Care. Health Care Financing Administration, : Research Associate. Evaluation of the Impact of the Medicare Prospective Payment System. Health Care Financing Administration, : Co-author and Research Associate. Indexes of Hospital Quality and Efficiency. Prospective Payment Assessment Commission, : Research Associate. The Measurement of Real Change in Case Mix. National Institute of Mental Health, : Research Associate. The Effect of PPS on Psychiatric Admissions in General Hospitals. Reviewer for Cancer, Medical Care, Inquiry, Hospitals & Health Services Administration, Clinical Performance and Quality Health Care, American Journal of Preventive Medicine, AUPHA 1991 Annual Meeting, Annals of Epidemiology(2006), Journal of the American Geriatrics Society (2006), Journal of General Internal Medicine

198 Curriculum Vitae: Amit Chattopadhyay January, 2008 AMIT CHATTOPADHYAY PhD, MPH, MDS, BDS (Hons), Diploma in Journalism, DcFM, MSASMS Diplomate: American Board of Dental Public Health CURRENT POSITION Assistant Professor: Dept. of Epidemiology, University of Kentucky College of Public Health, Lexington, USA. Adj. Asst. Professor: Div. of Dental Public Health, University of Kentucky College of Dentistry, Lexington, USA. EDUCATION, PROFESSIONAL & POST DOCTORAL TRAINING Public Health & Epidemiology PhD (Epidemiology): University of North Carolina at Chapel Hill, NC, USA. Graduate certificate in international development - University of North Carolina NC, USA. Graduate certificate in health outcomes and quality of care - University of North Carolina NC, USA. MPH (Master of Public Health): Epidemiology. University of Oklahoma Health Sciences Center, OK, USA. Dental Public Health Specialty Residency (Dental Public Health): Bureau of Dental Health, NY State Department of Health, Albany, NY, USA. Board Certified: American Board of Dental Public Health. Oral Pathology Specialty MDS (Master of Dental Surgery): Oral Pathology, Gujarat University, Ahmedabad, India. Dentistry BDS (Bachelor of Dental Surgery): Calcutta University, India; Honors in Physiology and Biochemistry. Other Diploma in Journalism: British Institutes, Bombay, India. DcFM (Doctorate certificate in Family Medicine): Society of Advanced Studies in Medical Sciences, N. Delhi. MSASMS (Member): Society of Advanced Studies in Medical Sciences, N. Delhi, India. PROFESSIONAL MEMBERSHIPS American Public Health Association; American Association of Public Health Dentistry; American Association of Dental Research, American Dental Education Association, Indian Association of Public Health, Indian Society of Dental Research; Dental Education Society of India; The Planetary Society. LICENSES North Carolina State Board of Dentistry: Instructor s dental license for practicing dentistry # Dental Council of India through WB State Board: Dental license: # 1080/A. SCIENTIFIC JOURNAL PEER REVIEWER Current: Archives of Oral Biology Current: American Journal of Public Health, Oral Diseases Current: Community Dentistry & Oral Epidemiology, Journal of Healthcare for the Poor and Underserved Current: Ambulatory Pediatrics, Journal of Public Health Dentistry Current: Caries Research, Health Services Research, Journal of Health Policy Current: Journal of Oral Pathology and Medicine Current: Journal of Dental Research, Journal of Rural Health. SCIENTIFIC GRANT PEER REVIEWER : Reviewer for School Health Index Implementation Mini-Grant Program. Granting body: American School Health Association, OH, USA. Page 1 of 9

199 Curriculum Vitae: Amit Chattopadhyay January, 2008 SCIENTIFIC - SCHOLARLY ACTIVITIES: Publications, Copyrights & Patents and Presentations Copyrights & Patents (those not mentioned elsewhere) Community based Dental Education (CBDE) Activity Assessment Form - CBDE (pretest) & CBDE (posttest). Effective date; Current Editorial Activities Guest Editor: Dental Clinics of North America Issue on Dental Public Health [2008; Vol 52 (No. 2)]. Publications Book Chapter Chattopadhyay A, Kumar JV. Fluoride Technology - A Global Perspective. In Textbook of Preventive and Community Dentistry. Hiremath SS, editor. 2007; New Delhi: Elsevier, pp Peer Reviewed Publications Under review Amit Chattopadhyay, Sharmila Chatterjee. Secretory Leukocyte Protease Inhibitor in the Gastrointestinal Tract. Acta Pathologica, Microbiologica et Immunologica Scandinavica. Amit Chattopadhyay, Lauren L Patton. Is smoking a risk factor for oral candidiasis in HIV-1 infected persons? Journal of Oral and Maxillofacial Pathology and Medicine. Amit Chattopadhyay, Daniel J. Caplan, Gary D. Slade. Unreimbursed oral health care by dentists in the US: evidence from Medical Expenditure Panel Survey, Community Dental Health. Ray JG, Halder M, Mukherjee S, Ray M, Chattopadhyay A. DNA damage and oral habits in oral cancerprecancer patients. Indian Journal of Cancer. In press /Accepted Chattopadhyay A. Oral Health Disparities in the United States. Dental Clinics of North America. Chattopadhyay A, Arevalo O, Sohn W. Understanding Measurement of Dental Diseases and Research Participation in Practice Set-Up. Dental Clinics of North America. Amit Chattopadhyay, Oscar Arevalo, James C. Cecil. Status of Oral Health in Kentucky - Progress towards 2010 Objectives - A Mid Course Review. Journal of Kentucky Medical Association. In print Amit Chattopadhyay, Jay G. Ray. Bootstrap validation of AgNOR cut-point to distinguish epithelial dysplasia. Journal of Oral and Maxillofacial Pathology and Medicine. 2008;37: Chattopadhyay A, Ray J: Successful management of pulpal involvement using pulpotomy in adults. Clinical Dentistry, Dec 2007,pp Chattopadhyay A, Patton L: Risk indicators of HIV-Associated jointly occurring oral candidiasis and oral hairy Leukoplakia. Aids Patient Care and STDs. Vol 21, No , pp Diane C. Shugars, Margo Adesanya, Scott R. Diehl, Robert S. Redman, Kevin J. Malley, Rebeka G. Silva, Sam E. Farish, Thomas Francis, Robert M. Craig, Trina Jones-Richardson, C. Richard Buchanan, Ruth Jordan, Amit Chattopadhyay, Deborah E. Winn. Self-awareness of premalignant oral lesions among United States veterans. Journal of Special Care Dentistry 2007; 27: Amit Chattopadhyay, Sharmila Chatterjee. Epidemiology of Recurrent Aphthous Ulcers among Adults in the United States. Community Dentistry and Oral Epidemiology 2007; 35: E Schaff-Blass, R. G. Rozier, A. Chattopadhyay, R Quinonez, W F. Vann. Effectiveness of an Educational Intervention in Oral Health for Pediatric Residents. Ambulatory Pediatrics 2006;6: E. Blignaut, L.L. Patton, W. Nittayananta, V. Ramirez-Amador, K. Ranganathan, A. Chattopadhyay. (A3) HIV Phenotypes, Oral Lesions, and Management of HIV-related Disease. Adv Dent Res 19: , April, Page 2 of 9

200 Curriculum Vitae: Amit Chattopadhyay January, 2008 Kishore Shetty, Amit Chattopadhyay, Janet E Leigh. Detection and Typing of Human Papilloma Virus in the Oral Mucosa of Patients Infected with Human Immunodeficiency Virus. Oral Oncology Extra 2005 November; 41: Okunseri C, Chattopadhyay A, Lugo IR, McGrath C. Pilot survey of oral health related quality of life. A crosssectional study of adults in Benin City, Nigeria. BMC Oral Health Jul 25;5(1):7 Chattopadhyay A, Caplan DJ, Slade GD, Shugars DC, Tien H-C, Patton LL. Risk indicators for oral candidiasis and oral hairy leukoplakia in HIV-infected adults. Community Dent Oral Epidemiol 2005; 33: Chattopadhyay A, Caplan DJ, Slade GD, Shugars DC, Tien, H-C, Patton LL. Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99(1): Okunseri C, Chattopadhyay A. Self Reported Dental Visits among Adults in Benin City, Nigeria. International Dental Journal. 2005; 54: Amit Chattopadhyay, Laurie R. Gray, Lauren L. Patton, Daniel J. Caplan, Gary D. Slade, Hsaio-Chuan Tien, and Diane C. Shugars. Salivary secretory leukocyte protease inhibitor and oral candidiasis in HIV-1 infected persons. Infection and Immunity 2004; 72(4): Chattopadhyay A, McKaig RM. Development of poor commercial sex workers in India as an essential step in HIV/AIDS prevention. AIDS Patient Care and STDs. 2004; 18(3): Chattopadhyay A, Kumar JV, Greene EL Determinants of dental health care utilization among the minorities in New York State: Report from the NY Minority Health Survey, Journal of Public Health Dentistry 2003;63(3): Chattopadhyay A, Slade GD, Shugars DA. Costs of oral health care during a period of economic growth in the US: Journal of Public Health Dentistry 2003;63(2): Ray JG, Chattopadhyay A, Caplan, DJ. Usefulness of AgNOR counts in diagnosing epithelial dysplasia. Journal of Oral Pathology and Medicine Feb;32(2): Chattopadhyay A, Ray JG, Caplan, DJ. AgNOR counts as objective marker for dysplastic features in oral leukoplakia. Journal of Oral Pathology and Medicine. 2002;31: A.Chattopadhyay, K. Srinivas. Transposition of teeth and genetic etiology. The Angle Orthodontist. 1996;66(2): Chattopadhyay A, K. Srinivas, B. Sharatchandra, N.Kannan. The Marcus Gunn phenomenon: Discussion and report of three cases. Quintessence International (8): Chattopadhyay A., J.G. Chawda, J.J. Doshi. Silver binding nucleolar-organizing regions: a study of oral leukoplakia and squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery (6 Pt 1): Amit Chattopadhyay, Atul Sattur. Rubinstein Taybi Syndrome: Case report. Stomatologica India. 1995;9(1-2): Amit Chattopadhyay. Giant cells and giant cell lesions of the oral cavity. Journal of Indian Dental Association (11): Amit Chattopadhyay. The granulomatous response and the oral cavity. Ind Journal of Dental Research (1):15-8 Amit Chattopadhyay. Reasons for extraction of third molar teeth. Journal of Indian Dental Association (3): Amit Chattopadhyay, P.K. Dayal. Orofacial granulomatosis. A review of literature and report of five cases. Indian Journal of Dental Research (2) : Amit Chattopadhyay. Adenomatoid odontogenic tumor. Review of literature and report of 30 cases from India. Indian Journal of Dental Research (3): Amit Chattopadhyay, Kirti Nandimath, Ramaswamy Pachigolla. Varicose veins of the oral cavity: A survey report of 3402 cases. Indian Journal of Dermatology (2): Amit Chattopadhyay. AgNORs in tumoral pathology. Review of literature and observations on the technique and reactions in normal oral epithelium. Indian Journal of Dental Research (2): Amit Chattopadhyay. Arterial blood pressure and blood glucose levels in oral lichen planus patients in Calcutta, India. Indian Journal of Dental Research (3): Amit Chattopadhyay. AgNORs in oral squamous cell carcinoma. Oral Oncology. Vol II. Proceedings of the International Congress on oral cancer, New Delhi, India. 1991; I: McMillan India Ltd, Delhi. Page 3 of 9

201 Curriculum Vitae: Amit Chattopadhyay January, 2008 Parveen Sharma, Amit Chattopadhyay. Malignant melanoma of the oral cavity. Indian Journal of Dermatology (3): Amit Chattopadhyay. Career aspirations of dental students in a dental college in Calcutta, India. Indian Journal of Dental Research (1-2): Amit Chattopadhyay, R.D. Rekhade, A. Surana, R.N. Poddar. Cysts of the Jaws. Indian Journal of Surgery (5): Amit Chattopadhyay. Self-assessed oral health awareness and unmet demands among medical and dental professionals in Calcutta, India. Community Dentistry and Oral Epidemiology (3): Amit Chattopadhyay, R.S. Deol. Reasons for choice of Dentistry as a career in Calcutta: a survey report. Indian Journal of Dental Research (1): Amit Chattopadhyay. Intraoral solitary Lipomas: a clinicopathologic evaluation of eleven cases in Calcutta, India. Journal of Odontology, Stomatology and Maxillofacial Surgery (6): 5-7. Amit Chattopadhyay. Epidemiologic studies of oral cancers in Eastern India. Indian Journal of Dermatology (3): Amit Chattopadhyay. Hemoglobin levels in cancer and precancer patients. Journal of Current Biosciences (1): 1-3. Amit Chattopadhyay. Oral malignant neoplasms: a comparative study of material of 20 years. Journal of Odontology, Stomatology and Maxillofacial Surgery (3): Amit Chattopadhyay. Analysis of oral premalignant lesions - a study of material of 20 years. Stomatologica India (1): Amit Chattopadhyay. Intra-oral Leiomyosarcoma: a review of literature. Stomatologica India : Amit Chattopadhyay, Bimal C. Bera. Profile of geriatric patients visiting a Dental College and Hospital in India. Gerodontics (5): Amit Chattopadhyay. Study of epidemiological features of oral lichen planus. Indian Journal of Dermatology (1): Peer Reviewed Abstracts under Review Amit Chattopadhyay, Sharmila Chatterjee, Oscar Arevalo. Year-to-year variation in oral cancer incidence and mortality among American Indians & Alaskan Natives: National Oral Health Conference, Miami, April 28-30, Oscar Arevalo, Amit Chattopadhyay, Harold Lester. Capital budgeting analysis and mobile dental operations: the University of Kentucky College of Dentistry's experience. National Oral Health Conference, Miami, April 28-30, 2008 Peer Reviewed Abstracts Accepted (in press) Peer Reviewed Abstracts in Print Amit Chattopadhyay, Sharmila Chatterjee. Barriers to improving survival from oral cancer. American Public Health Association 135th Annual Meeting -- Washington, DC November 3-7, Amit Chattopadhyay. Why has oral cancer survival not decreased - multiple dimensions of oral cancer survival? 1 st World Congress of the International Academy of Oral Oncology, Amsterdam, the Netherlands, May 17 20, Amit Chattopadhyay, Oscar Arevalo, Nishita R. Matnani, James C. Cecil - III. Oral health status of Kentucky residents: a mid-course evaluation towards 2010 objectives. National Oral Health Conference, Denver, April 30 - May 2nd, Oscar Arevalo, Amit Chattopadhyay, Karen P. West. Community based dental education program at University of Kentucky - a preliminary report. National Oral Health Conference, Denver, April 30 - May 2nd, Amit Chattopadhyay, Lauren L. Patton. Is smoking a risk factor for oral candidiasis in HIV-1 infected persons? National Oral Health Conference, Denver, April 30 - May 2nd, Amit Chattopadhyay, Lauren L Patton. Developing an oral index for HIV/AIDS disease progression. Abstract ID# At the 85th International, American and Canadian Associations for Dental Research, New Orleans, LA, USA on March 21-24, web site: Page 4 of 9

202 Curriculum Vitae: Amit Chattopadhyay January, 2008 Amit Chattopadhyay, Jay G. Ray. DNA Damage and oral habits in oral cancer & precancer patients. J Public Health Dent. 2006V;6(Supp 1):S53. Daniel Uzbelger, Daniel Bitner, Roy Stevens, Amit Chattopadhyay. Effectiveness of Supplemental Cervical Plexus Anesthetic Technique for Achieve Anesthesia in Mandibular Molars with Irreversible Pulpitis. American Association of Endodontics Annual session, Philadelphia, PA, USA on April 25-28, Amit Chattopadhyay. Unreimbursed oral health care by dentists in the US: Evidence from Medical Expenditure Panel Survey, Abstract # ; APHA Conference 2006, Boston, USA. Published at APHA conference web site: Amit Chattopadhyay, Jay G. Ray. DNA Damage and Oral habits in Oral Cancer Precancer Patients. Education, Prevention and Access: A Bridge to Optimum Oral health National Oral Health Conference. # 56, P 44. AAPHD & ASTDD, Oscar Arevalo, Sunil Vick Soordhar, Amit Chattopadhyay, R. Ivan Lugo. Incorporating Expanded Function Dental Assistants (EFDA) in the Dental School Curriculum. Abstract #120423; APHA Conference 2005, Philadelphia, USA. Published at APHA conference. web site: A. Chattopadhyay, Christopher Okunseri, R. Ivan Lugo. Oral Health Related Quality of Life in Nigeria. Journal of Dental Education. 2005; 69: M.Khedr, A. Chattopadhyay, I. Ganem, Jeffrey L. Perry. Journal Impact Factor Effectiveness - Where Is the Evidence? Journal of Dental Education. 2005; 69: Oscar Arevalo, A. Chattopadhyay, Carlos Echeverri, Andres F. Gaitan. Measuring Community Based Dental Education Experience of Predoctoral Students. Journal of Dental Education. 2005; 69: Ivonne. Ganem, R. Ivan Lugo, Oscar Arevalo, A Chattopadhyay. Community Based Comprehensive Care Dental Training Program for Dental Students. Journal of Dental Education. 2005; 69: Amit Chattopadhyay, Lauren L. Patton, Daniel J. Caplan. Risk Indicators for Jointly Occurring Oral Candidiasis and Hairy Leukoplakia. Journal of Dental Research; 83 (Spec Iss A): abstract # 2989, Amit Chattopadhyay, Andriani Daskalaki, Daniel J. Caplan, Jay G. Ray. Bootstrap validation of ROC-based AgNOR cut-off to diagnose epithelial dysplasia. Journal of Dental Research; 83 (Spec Iss A): abstract # 1238, S.P. Russo, J.R. Kaplan, M.R. Adams, S. Offenbacher J.D. Beck, R.C. Williams, A. Chattopadhyay, D.W. Paquette. C-reactive protein levels and periodontitis in monkeys. Journal of Dental Research 2003; 82 (spec issue B): B-365, abstract # D.W. Paquette, S.P. Russo, J.R. Kaplan, M.R. Adams, A. Chattopadhyay, J.D. Beck, R.C. Williams, S. Offenbacher. Serum IgG antibody responses to periodontal pathogens in monkeys. Journal of Dental Research 2003; 82 (spec issue B): B-365, abstract # D. Paquette, R. Longbottom, E. Riche, J. Jaquot, S. Offenbacher, A Chattopadhyay, R. Williams. Preclinical evaluation of delta 12-prostaglandin-J2 in dogs with peri-implants osseous defects. Journal of Dental Research 2002; 81 (spec issue A): A-39, abstract # D. Paquette, A. Rosenberg, P. McDonough, C. Szabo, A. Salzman, A Chattopadhyay, R. Williams. Preclinical evaluation of inducible nitric oxide synthase inhibitors in canines with experimental gingivitis. Journal of Dental Research 2002; 81 (spec issue A): A-498, abstract # A. Chattopadhyay, JV Kumar. Results of the New York State Minority Health Survey. Journal of Dental Research 2000; 78 (spec issue): 551, abstract Amit Chattopadhyay. Oral health awareness and demands among medical and dental professionals. Proceeding of the Asian Pacific Dental Congress, 1988, New Delhi, India. Dissertation/ Thesis Amit Chattopadhyay: HIV-associated oral disease: Prevalence, incidence and role of secretory leukocyte protease inhibitor. PhD dissertation, May. 2003, University of North Carolina at Chapel Hill, NC, USA. Amit Chattopadhyay. Epidemiology of HIV/AIDS in India - development of commercial sex workers as an important strategy to stem the HIV/AIDS epidemic. Carolina Papers - International Development. No. 9 (Spring 2003). University Center for International Studies. The University of North Carolina at Chapel Hill. Also available at Amit Chattopadhyay: Quantitative AgNOR histochemistry in normal oral epithelium, leukoplakia and squamous cell carcinoma. MDS thesis Oct. 1992, Gujarat University, Ahmedabad, India Page 5 of 9

203 Curriculum Vitae: Amit Chattopadhyay January, 2008 Non-Peer Reviewed Scientific Publications Amit Chattopadhyay. Recent advances in hepatitis vaccine scene. Medical Pulse (7): Amit Chattopadhyay. Adverse effects of drugs on the gastrointestinal tract. Medical Pulse (7): Amit Chattopadhyay. Reasons for extraction of various tooth types in India. Medical Pulse (4): Amit Chattopadhyay. Stylohyoid and Stylomandibular ligament complex: Variations in anatomy and symptomatology complex. Medicine Update (5): Amit Chattopadhyay. Lichen Planus. Medical Pulse (5): Amit Chattopadhyay. Vesiculobullous diseases. Immunological aspects. Medical Pulse. 3 (6) Amit Chattopadhyay. NSAIDs in practice. Medical Pulse (7) Amit Chattopadhyay. Asthma. Medical Pulse (7): Amit Chattopadhyay. Primary melanoma of the oral cavity. Medical Pulse (1): 14. Amit Chattopadhyay. Angina pectoris: An over view. Medical Pulse (1) Amit Chattopadhyay. Cancer metastasis to oral tissues. West Bengal State Dental Journal (WBSDJ) (1): Amit Chattopadhyay. Paan masala and betel nut may lead to oral cancer. Science Reporter : 669. Amit Chattopadhyay. Biochemical basis of action of fluorides on dental apatites: an insight. WBSDJ (1): 1-6. SCIENTIFIC PRESENTATIONS Invited Lectures Advanced Medicare and Research Institute, Kolkata, India: Research methods in Clinical Medicine. December 12-14, National University of Singapore, Singapore: Secretory Leukocyte Protease Inhibitor and Mucosal Pathology - The Case of Oral Candidiasis and Gastric Helicobacter pylori Infections, July National Oral Health Conference, Denver, CO, USA. Special plenary session panel on HIV-associated oral diseases. Is smoking a risk factor for oral candidiasis in HIV-1 infected persons? April 30, Key-Note address at the Indian Association of Public Health Dentistry, XI National Conference, Shimla, India: Predicting Survival from Oral Cancer. December 9 th 10 th, Advanced Medicare and Research Institute, Kolkata, India: Issues in Clinical Trials Errors, Biases and Blinding. December 6 th, Invited to Rising Stars section of ADA annual conference, Philadelphia Rising Stars: Charity care! Who does not pay back for dental treatment? (Course Number: N657) October 7 th, Invited to the panel of international experts to present in Workshop 1A, titled "Oral lesions, HIV phenotypes and management of HIV-related disease" at the 5th International World Workshop Conference on Oral Health and Disease in AIDS, to be held from July 6 to July 10, 2004 in Phuket, Thailand. Institute of Dentistry, University of Turku, Finland: Epidemiology of HIV associated oral diseases and the role of salivary secretory leukocyte protease inhibitor. February, University of California, at Los Angeles, CA, USA. Epidemiology of HIV associated oral diseases. April, University of Alabama at Birmingham, AL, USA: Role of AgNORs in diagnosing oral epithelial dysplasia, February, Invited speaker at Dr. R.A. Dental College, Calcutta, India: Biomarkers for HIV associated oral diseases; Genetics of Head-Neck cancer; Clinical research methodology. June, Other Presentations IADR, 2000, Washington DC. Analysis of Minority Health Survey and BRFSS. AAPHD conference, 2000, Chicago. NY State Minority Health Survey. RECENT TEACHING ACTIVITIES Current Page 6 of 9

204 Curriculum Vitae: Amit Chattopadhyay January, 2008 University of Kentucky College of Public Health & College of Dentistry Graduate Epidemiology Elective Courses Course Director & Lecturer: CPH 718: Oral Health Epidemiology. This is a totally new course conceived, planned, designed by me and taught for the first time. Currently, to the best of my knowledge, no similar course at this level exists in the US. Guest lecturer in following Epidemiology Courses: Chronic Disease Epidemiology, Advanced Methods in Epidemiology Graduate Oral Biology Core Courses Course Lecturer: OBI-650 (Oral Biology): Research Methodology, Study Design and Causation topics. Per- doctoral (DDS) Courses Course Lecturer: CDE 830 (Dental Public Health): Biostatistics and Epidemiology topics Graduate Epidemiology Core Courses Course Director & Lecturer: CPH 605: Introduction to Epidemiology Temple University School of Dentistry Graduate Oral Biology Core Courses Course Director & Lecturer: Oral Biology 418: Research Methodology and Study Design Course Director & Lecturer: Oral Biology 425: Biostatistics Pre professional (DMD) Courses Course Director& Lecturer: D-307: Dental Public Health Community Based Education (DMD) Courses Director: Community Based Dental Education Program Temple University College of Health Professions Course director: PH 679: Epidemiology of HIV/AIDS New courses developed: PH 679: Epidemiology of HIV/AIDS PH 670: Intermediate epidemiological methods Temple University School of Dentistry Lecturer co-teaching: D-307: Dental Public Health University of North Carolina at Chapel Hill School of Dentistry Lecturer Dent 101: Preventive Dentistry Clinical instructor Diagnosis and Treatment Planning clinic for predoctoral students University of North Carolina at Chapel Hill School of Public Health (Epidemiology dept) Co-teaching (Graduate teaching assistant) Page 7 of 9

205 Curriculum Vitae: Amit Chattopadhyay January, 2008 Epid-160: Principles of Epidemiology and Public Health (Web based). RECENT SERVICE ACTIVITIES UoK Student Capstone Projects (see later) UoK service Projects 2006 Current. Member, dental billing compliance committee, UoK College of Dentistry. Registered as mentor in the University of Kentucky College of Dentistry Dental Scholars Program. Special projects other (non UoK) Universities 1. Co-founder, Department of Dental Public Health Sciences at Temple University School of Dentistry, USA. With support from the Chairman of the department, I drew the department academic, and research plan and structure to establish the new entity of Dental Public Health Sciences which hitherto did not exist in the school. As a formal entity, the department will come into existence in July Co-founder and Director of Community Based Dental Education Program (CBDEP). With support from the Chairman of the department, I planned the academic and programmatic structure, content and outcome measures for the new CBDEP which hitherto did not exist at Temple University School of Dentistry, USA. This included design and implementation of standardization and calibration of all faculty members involved in the CBDEP. 3. I planned the academic and programmatic structure and proposed a new dual degree (DMD/MPH) program in collaboration with the Department of Public Health, college of Health Professions at Temple University, which hitherto did not exist at Temple University School of Dentistry, USA. Currently the proposal is under consideration by the University decision making body. University/ school administration committees 2007 Current: Member University of Kentucky College of Public Health Dean s Advising Taskforce Current: Interprofessional Education Committee, University of Kentucky, USA Current: Dental Billing Compliance Committee, University of Kentucky, College of Dentistry, USA : Member Promotions & Tenure Committee, Temple University School of Dentistry, USA : Member Admissions Committee, Temple University School of Dentistry, USA : Member Research & Advanced Education Committee, Temple University School of Dentistry, USA : Member Research and Study Leave Committee, Temple University School of Dentistry, USA : Ad hoc member Honor Code Administrator, Temple University School of Dentistry, USA. Outreach program support : Director of Community Based dental Education Program : Developed TUSoD Community based dental education system. Helping TUSoD effort for community outreach clinic programs and community based dental education program through program design, implementation, data collection instrument development, analysis and report writing. THESIS COMMITTEES AND STUDENT RESEARCH SUPPORT UoK DrPH Mentor, Research Support & Committees: 2007: Juan R. Yepes. Doctor of Public Health (DrPH) student. University of Kentucky College of Public Health, KY, USA. Chairperson: UoK MPH Capstone Project Research Support & Committees: : Dolphus Dawson. Randomized trial of antibiotics as adjuvant to conventional therapy in periodontal disease management. UoK MPH Capstone Project Research Support & Committees: 2007: Juan R. Yepes. Oral Cancer Disparities in Kentucky. University of Kentucky College of Public Health, KY, USA. Page 8 of 9

206 Curriculum Vitae: Amit Chattopadhyay January, : Ashley McCarty. Oral Health in Fayette County School Children. University of Kentucky College of Public Health, KY, USA. 2006: Dr. Julie Schuster. Maternal Salivary Biomarkers, Oral Health, and Potential for Adverse Pregnancy Outcomes. University of Kentucky College of Dentistry, KY, USA. Other (non UoK) University Residency Project Research Support & Committees: 2006: Dr. Logesh Swayam. Determinants of dental care utilization in South East Pennsylvania analyses of SEPA household survey. West Chester University School of Public Health, PA, USA. 2006: Dr. Amit Kumar. A-life experiments in dentistry. Department of Dental Ecology, University of North Carolina at Chapel Hill, NC, USA. 2006: Dr. Daniel Bitner. Clinical trial for testing cervical nerve supply block of mandiubular molars. Dept. of Endodontics, Temple University School of Dentistry. 2006: Dr. Kydo Hung. Comparison of Laser, rotary and hand instruments in modifying root canal curvature and apical transport. Dept. of Endodontics, Temple University School of Dentistry. 2005: Dr. Rahul Gupta. Using methyline blue dye to detect extra mesio-buccal canals in molars. Dept. of Endodontics, Temple University School of Dentistry. Graduate Program coordinator, MDS thesis advisor and academic counselor: 1998: Dr. V.K. Prashanth. Genetic analysis of Transposition of teeth. PhD, thesis, Pacific Western University, USA. 1993: Dr. K. Srinivas. Orofacial genetic abnormalities; Karnataka University, India. 1993: Dr. B. Sharatchandra. Radiographic diagnosis or orofacial conditions; Karnataka University, India. 1993: Dr. N. Kannan, Clinically feasible early detection systems for oral cancer and precancer; Karnataka University, India. 1993: Dr. P. Ramaswamy. Oral submucous fibrosis: clinical efficacy of oxidants; Karnataka University, India. JOURNAL EDITORIAL AND CONSULTATION COMMITTEES 2006 Current: Consultant to Journal of Indian Association of Public Health Dentistry Current: Overseas Contributing Editor: Medicine Update Middle East Page 9 of 9

207 CURRICULUM VITAE Glyn G. Caldwell, M.D. Assistant Professor Vice Chairman, Department of Epidemiology College of Public Health University of Kentucky Education: Shepard Elementary and Roosevelt High School, St. Louis, Missouri, Graduated 1952 B.S.: St. Louis University, 1960 (Zoology) M.S.: University of Missouri, Columbia, 1962 (Microbiology) M.D.: University of Missouri, Columbia, 1966 Intern: U.S.P.H.S. Hospital, Brighton, Massachusetts, Diplomat: National Board of Medical Examiners, 1967 Resident: Internal Medicine, Cleveland Metropolitan General Hospital Cleveland, Ohio, Medical Licensure: Missouri, Georgia, Arizona, Oklahoma, Indiana, Kentucky, Professional Data: U.S. Army (Signal Corps) Graduate Instructor in Microbiology, University of Missouri United States Public Health Service Medical Virologist-Epidemiologist, Ecological Investigations Program (EIP), Centers for Disease Control (CDC), Kansas City, Kansas Assistant Professor Microbiology, University of Kansas Chief, Leukemia and Oncogenic Virus Activities, EIP, CDC, Kansas City, Kansas Chief, Viral Diseases Section, EIP, CDC, Kansas City, Kansas Chief, Oncology and Teratology Activities, EIP, CDC, Kansas City, Kansas Docent, Kansas City General Hospital, Kansas City, Missouri Clinical Assistant Professor of Medicine, University of Missouri, Kansas City Biohazards Consultant, EIP, CDC, Kansas City, Kansas Assistant to the Chief, Leukemia Section, Cancer and Birth Defects Branch, Bureau of Epidemiology (EPI), CDC, Atlanta, Georgia

208 Professional Data (continued) Deputy Chief, Leukemia Branch, Cancer and Birth Defects Division, EPI, CDC, Atlanta, Georgia Clinical Assistant Professor of Preventive Medicine and Community Health, Emory University, Atlanta, Georgia Director, Atlanta Cancer Surveillance Center, Emory University, Atlanta, Georgia Chief, Cancer Branch, Chronic Diseases Division (CDD), EPI, CDC, Atlanta, Georgia Deputy Director, CDD, Center for Environmental Health (CEH), CDC, Atlanta, Georgia Assistant Director for Epidemiology, CDD, CEH, CDC, Atlanta, Georgia Emergency Response Coordinator, CDD, CEH, CDC, Atlanta, Georgia Assistant Director, Arizona Department of Health Services, Division of Disease Prevention, Phoenix, Arizona Clinical Assistant Professor, Department of Community Medicine, University of Arizona Arizona State Epidemiologist Deputy Director, Arizona Department of Health Services (ADHS) 1988 Acting Assistant Director, Division of Emergency Medical Services 1988 Acting Assistant Director, Health Care Facilities, ADHS Acting Assistant Director, Division of Family Health Services, ADHS Director, Tulsa City-County Health Department, Tulsa, Oklahoma Clinical Assistant Professor, University of Oklahoma, College of Medicine, Tulsa, Oklahoma Adjunct Professor, Oklahoma State University, College of Osteopathic Medicine, Tulsa, Oklahoma Medical Consultant, Tulsa City-County Health Department, Tulsa, Oklahoma Consultant-Agency for Nuclear Projects, Nuclear Waste Project Office, Nevada (Yucca Mountain Nuclear Waste Repository) Associate Clinical Coordinator, Indiana Medical Review Organization Associate Clinical Coordinator, Health Care Excel, Incorporated Director, Division of Epidemiology and Health Planning, Kentucky Department for Public Health and Kentucky State Epidemiologist Clinical Assistant Professor, University of Kentucky, School of Public Health University of Kentucky, School of Public Health, Assistant Professor Vice-Chairman, Department of Epidemiology, Consultant 2003 University of Kentucky, School of Public Health, Interim Director Kentucky Injury Prevention and Research Program

209 Committee Memberships: Interagency Task Force on the Health Effects of Ionizing Radiation Interagency Committee on Federal Research into the Biological Effects of Ionizing Radiation Centers for Disease Control Medical Advisory Board Interagency Radiation Research Committee Subcommittee on Three Mile Island Subcommittee to Develop the Federal Strategy for Research into the Biological Effects of Ionizing Radiation 1982 Subcommittee on Agency Management and Implementation 1984 Subcommittee to Estimate the Feasibility of a Veterans Administration Health Assessment of Veterans with Military Services at Sites of Temporarily Augmented Radiation Department of Health and Human Services (DHHS) Committee on Health Research Initiatives on Radiation Research Federal Emergency Management Agency-Federal Interagency Central Coordinating Committee for Radiation Planning and Preparedness Steering Committee on Federal Response Exercises Subcommittee on Federal Response DHHS Coordinating Committee on Environmental and Related Programs (CCERP) Subcommittee to Coordinate Radiation Activities Environmental Health Executive Committee Subcommittee on Hazardous Chemical Spills Subcommittee on Toxic Waste Dumps Department of Energy, Dosimetry Assessment Advisory Committee of the Offsite Radiation Exposure Review Program, Nevada Test Site Health Resources Administration, Working Group to Implement PL Arizona HIV-AIDS Control Committee, Arizona Department of Health Services 1986 Hanford Health Effects Review Committee, Chairman Human Subjects Review Committee Chairman, ADHS American Cancer Society, Arizona Division Professional Education Committee, Chairman 1988 Divisional Vice President Arizona Tuberculosis Control Advisory Committee, ADHS Arizona Department of Transportation, Medical Advisory Board Arizona Health Care Cost Containment System, Medical Advisory Board Arizona Emergency Response Commission Arizona Children's Trust Fund Advisory Committee City of Phoenix AIDS Task Force Association of State and Territorial Health Officials, Environment Committee Hanford Environmental Dose Reconstruction Program, Technical Steering Panel

210 Committee Memberships (continued) Arizona Advisory Committee on Alzheimer's Disease and Related Disorders 1990 Arizona Governor's Task Force on Arthritis Medical Advisory Board, Parent Child Center, Tulsa, Oklahoma Board of Directors, HIV Resource Center, Chairman, , Secretary, Board of Directors, Save Our Babies Program, Metropolitan Tulsa Urban League Tulsa Regional Planning Board for Children and Youth Services Co-Chairperson, Tulsa City/County Homelessness Standing Committee University of Oklahoma, College of Public Health, Board of Visitors Local Development Act Review Committee, Tulsa, Oklahoma Scientific Review Panel - Electromagnetic Fields and Human Health (Cancer): Review of Epidemiologic Studies, University of Oklahoma School of Public Health (funded by the Oklahoma Gas & Electric Company) Family Violence Council, Tulsa, Oklahoma Hanford Health Effects Federal Advisory Committee, Subcommittee, Agency for Toxic Substances and Disease Registry Chairman Indiana State Department of Health, Tuberculosis Elimination Committee Public Education Committee Kentucky Traumatic Brain Injury Trust Fund Board Chairman, Kentucky Governor s Committee on the Paducah Gaseous Diffusion Plant Kentucky Medicaid Quality Improvement Advisory Council University of Kentucky, School of Public Health External Advisory Committee University of Kentucky, School of Public Health, Self-Study Accreditation Steering Committee Advisory Committee for the Fatality Assessment and Case Evaluation Project University of Kentucky, School of Public Health, Practice and Service Committee University of Kentucky, College of Public Health, Kentucky Injury Prevention Research Center, Integrated Core Injury Prevention and Control Executive Committee University of Kentucky, College of Public Health, Faculty Council Chairman, Advisory Committee for the Kentucky Violent Death Reporting System

211 Committee Memberships (continued) University of Kentucky, College of Public Health, Kentucky Injury Prevention and Research Center, Kentucky Violent Death Reporting System Advisory Board University of Kentucky, Pandemic Influenza Task Force University of Kentucky, College of Public Health, Administrative Council University of Kentucky, College of Public Health, Ad Hoc Strategic Planning Committee University of Kentucky, College of Public Health, Ad Hoc Curriculum Committee Memberships: Fellow, American College of Epidemiology American Medical Association, American Public Health Association, American Society of Microbiology, Commissioned Officers Association of the U.S. Public Health Service, Secretary-Treasurer, Kansas City Branch, Member-at-Large, Atlanta Branch, Vice-President, Atlanta Branch, 1975 President, Atlanta Branch, 1976 Knights of Columbus, Phi Chi Medical Fraternity, Society for Epidemiologic Research, Sigma Xi Oklahoma State Medical Association, Tulsa County Medical Society Alternate Delegate, 1992 Council on Community Relations, Delegate, American Association for the Advance of Science Kentucky Medical Association, Franklin County Medical Society, Kentucky Association of Public Health Physicians, President, Awards: Competitive Scholarship, St. Louis University 1966 McComas History of Medicine Prize, University of Missouri 1980 United States Public Health Service Commendation Medal 2007 Delta Omega Public Health Honorary Society 2007 President-elect

212 Interests: General Epidemiology Cancer Epidemiology Environmental Epidemiology Interests (continued): Infectious Disease Epidemiology Radiation Epidemiology Tumor Virology Public Health Management Public Health Education Teaching Responsibilities: Introduction to Epidemiology Emerging and Infectious Disease Epidemiology Public Health Response to Disasters and Terrorism Applied Epidemiology Miscellaneous: Contributing Editor International Journal of Cancer Control and Prevention, Radiation Emergency Response, Radiation Emergency Assistance Center/Training Site, Oak Ridge Associated Universities, American Management Association, Four-week Management Course, Editorial Consultant, Biosciences Information Service, Arizona State University, Center for Executive Development, College of Business Course in Strategic Management, Risk Analysis in Occupational and Environmental Health, Harvard School of Public Health, Urban Air Toxics, Air Pollution Training Institute, Environmental Protection Agency, Regulations on Bloodborne Pathogens, Oklahoma State Medical Association, Health Resources and Services Administration, University of Louisville/University of Kentucky, Department of Agriculture Bioterrorism Grant for Agricultural Extension Agents, Kentucky Injury Prevention and Research Center, Centers for Disease Control, Injury Prevention Planning Grant, Facilitator Publications: Hill, H.R., Caldwell, G.G., Wilson, E., Hager, D., and Zimmermann, R.A.: Epidemic of Pharyngitis due to Streptococci of Lancefield Group G. Lancet 2: , 1969,

213 Publications (continued) Cesario, T.C., Nakano, J.H., Caldwell, G.G., and Youmans, R.A.: Paralytic Poliomyelitis in an Unimmunized Child. American Journal of Diseases of Children 118: , Davis, L.E., Caldwell, G.G., and Hess, H.: Test Tube Epidemic. American Journal of Nursing , Cesario, T.C., Caldwell, G.G., and Chin, T.D.Y.: Studies on the Susceptibility of Organ Cultures to Infection and on the Localization of the Virus in the Cultures. J Inf Dis 121:70-73, Davis, L.E., Caldwell, G.G., Lynch, R.E., Bailey, R.E., and Chin, T.D.Y.: Hong Kong Influenza: The Epidemiologic Features of a High School Family Study Analyzed and Compared to a Similar Study During the 1957 Asian Influenza Epidemic. Amer J Epidemiology , Cesario, T.C., Kriel, R.L., Caldwell, G.G., Davis, L.E., and Chin, T.D.Y.: Epidemiologic Observations of Virus Infections in Closed Population of Young Children. Amer J Epidemiology , Caldwell, G.G., Rosenlof, R.C., Lemon, H.M., Bailey, R.E., and Chin, T.D.Y.: Epidemiology of Leukemia-Lymphoma in Mid-Nebraska. Nebraska Med J 58: , , , Karchmer, R.K., Caldwell, G.G., and Chin, T.D.Y.: Leukemia Following Localized Irradiation for Carcinoma of the Larynx. Blood , Karchmer, R.K., Mellman, J.A., Caldwell, G.G., and Chin, T.D.Y.: Previous and Simultaneous Cancers in Patients with Leukemia. J Chronic Dis 27:5-13, Karchmer, R.K., Amare, M., Larsen, W.E., Mallouk, A.G., and Caldwell, G.G.: Alkylating Agents as Leukemogens in Multiple Myeloma. Cancer 33: , Caldwell, G.G., Lindsey, J.L., Wolff, H., Donnelly, D.D., and Bohl, F.N.: Epidemic of Adenovirus Type 7 Acute Conjunctivitis in Swimmers. Amer J Epidemiology 99: , Heath, C.W., Jr., Caldwell, G.G., Feorino, P.: Viruses and Other Microbes, in Fraumeni,J.F.,Jr. (ed), Persons at High Risk of Cancer: An Approach to Cancer Etiology and Control (Proceedings of a Conference sponsored by the National Cancer Institute and the American Cancer Society, Key Biscayne, Florida, December 10-12, 1974). New York Academic Press, pp , 1975.

214 Publications (continued) Stoopler, M.B., Caldwell, G.G., Zack, M.M., Housworth, W.J., and Heath, C.W., Jr., Sibship Size and Hodgkins Disease. New Eng J Med 292:1025, 1028, Caldwell, G.G., Baumgarterner, L., Carter, C., Cotter, S., Currier, R., Essex, M., Hardy, W., Olson, C., and Olsen, R.: Seroepidemiologic Testing in Man for Evidence of Antibodies to Feline Leukemia Virus and Bovine Leukemia Virus. Clemmesen, J. and Yohn D.S. (ed), Comparative Leukemia Research, 1975, Bibl Haemat 43: , Herbert, J.T., Birkhoff, J.D., Feorino, P., and Caldwell, G.G.: Herpes Simplex Virus Type II and Cancer of the Prostate. J Urology 116: , Caldwell, G.G. and Heath, C.W., Jr.: Case Clustering in Cancer, South Med J 69 (12): , Caldwell, G.G.: Discussion: Second Primary Malignancies as a Result of Therapy in International Workshop on Multiple Primary Cancers. Cancer 40: , Herbert, J.T., Feorino, P., Caldwell, G.G.: False-Positive Epidemic Infectious Mononucleosis. Am Fam Physician 15 (2): , Levine, P.H., Connelly, R., Heath, C.W., Jr., Caldwell, G.G., Terasaki, P.I., Mickey, M.R., and Fabrizio, P. An Evaluation of Antibody Titers to the Epstein-Barr Virus as a Test for Susceptibility to Cancer. In Proceedings of the Third International Symposium on Detection and Prevention of Cancer, pp , Caldwell, G.G., Bovine Leukemia Virus, Public Health Serologic Studies, Bovine Leukosis Symposium Proceedings, pp , Halperin, W., Altman, M., Steinhagen, A., Iaci, A.W., Caldwell, G.G., Maston, T., Bill, J., Abe, T., and Clark, J.F. An Epidemiologic Investigation of Clusters of Leukemia and Hodgkin's Disease in Rutherford, New Jersey. J Med Soc of New Jersey 77: , Caldwell, G.G., Kelley, D.B., and Heath, C.W., Jr. Leukemia Among Participants in Military Maneuvers at a Nuclear Bomb Test (Smoky) A Preliminary Report. JAMA 244: , Heath, C.W., Jr. and Caldwell, G.G.: Animal Malignancies and Their Relationship to Public Health. Steele,J.H., and Beran,G.W. (eds). Handbook of Zoonoses, Volume II, CRC Press, Inc., Boca Raton, Florida, pp ,1981. Caldwell, G.G., Cannon, S.B., Pratt, C.B., and Arthur, R.D. Serum Pesticide Levels in Childhood Colorectal Carcinoma Patients. Cancer 48: , 1981.

215 Publications (continued) Falk, H., Herbert, J., Crowley, S., Ishak, K.G., Thomas, LB., Popper, H., Caldwell, G.G. Epidemiology of Hepatic Angiosarcoma in the United States: Environ Health Perspect 41: , Caldwell, G.G. Department of Health and Human Services. Cancer Incidence and Mortality in Nuclear Test Participants--An Interim Report. In Control of Exposure of the Public to Ionizing Radiation in the Event of Accident or Attack. Proceedings of a Symposium Sponsored by the National Council on Radiation Protection and Measurements, pp , Falk, H., Caldwell, G.G., Ishak, K.G., Thomas, L.B. and Popper, H. Arsenic-Related Hepatic Angiosarcoma. American Journal of Industrial Medicine 2:43-50, Caldwell, G.G. and Health, C.W., Jr. Infectious Monoucleosis Case Surveillance Using Existing State Laboratory Data. Public Health Reports, November-December 1982, Vol. 97, No. 6, pp Falk, H., Caldwell, G.G., Stein, G.F. Presentation of Incident--Three Mile Island. In Chemical and Radiation Hazards to Children. Finberg,L. (ed), Report of the Eighty- Fourth Ross Conference on Pediatric Research, Columbus, Ohio, Ross Laboratories, pp , French, J.G., Falk, H., Caldwell, G.G. Examples of CDC's Role in the Health Assessment of Environmental Disasters, The Environmental Professional, Vol. 4, pp , Caldwell, G.G., Kelley, D.B., Zack, M.M., Falk, H., and Heath, C.W., Jr.: Mortality and Cancer Frequency Among Military Nuclear Test (Smoky) Participants, JAMA 250: , Tokuhata, G.K., Goldhaber, M.K., Digon, E., Caldwell, G.G., Stein, G.F., Lutz, G. and Gur, D. The Three-Mile Island Population Registry. Public Health Reports, Vol. 98, pp Caldwell, G.G. Chapter 16: Infections, Infestations and Cancer. Epidemiology of Cancer, edited by Geoffrey J. Bourke. Croom Helm, Ltd., London, pp , Hicks, N., Zack, M.M., Caldwell, G.G., Ferbach, D.J., Lloyd, D., and Falletta, J.M. Childhood Cancer and Occupational Radiation Exposure in Parents. Cancer 53: , Caldwell, G.G., Kelley, D.B., Heath, C.W.,Jr., and Zack, M.M. Polycythemia Vera Among Nuclear Test Participants. JAMA 252: , 1984.

216 Publications (continued) Caldwell, G.G. Book Review. Well Body and Well Earth. JAMA 252: , Hicks, N., Zach, M.M., Caldwell, G.G., and McKinley, T.W. Lifestyle Factors Among Patients With Melanoma. Southern Medical Journal, Vol. 78, No. 8, pp , August Dominguez, L.B., Caldwell, G.G., Novick, L.F. AIDS. Acquired Immunodeficiency Syndrome. Information and Guidelines Regarding HTLV-III Infections. Arizona Department of Health Services, Phoenix, Arizona, Caldwell, G.G. Book Review. Introduction to Environmental Health. JAMA 254:2671, Caldwell, G.G. Book Review. The Health Detective's Handbook: Guide to the Investigation of Environmental Health Hazards by Non-professionals. JAMA 255: , Dominguez, L.B., Englender, S.J., Caldwell, G.G. AIDS. Acquired Immunodeficiency Syndrome. Information and Guidelines Regarding HTLV-III Infections. Second Edition. Arizona Department of Health Services, Phoenix, Arizona, Cutler, J.J., Parker, G.S., Rosen, S., Prenney, B., Healey, R., Caldwell, G.G. Childhood Leukemia in Woburn, Massachusetts, Public Health Reports, Vol. 101, No. 2, pp , March-April, Caldwell, G.G. Book Reivew. Atomic Bomb Survivor Data: Utilization and Analysis. JAMA 256: , Caldwell, G.G. Time-Space Cancer Clusters. Health and Environment Digest, Vol. 3, No. 5, June Caldwell, G.G. Twenty-two Years of Cancer Cluster Investigation at the Centers for Disease Control. American Journal of Epidemiology, Vol. 132, Suppl. No. 1, pp. S43- S47, Caldwell, G.G. Book Review. Hanford Radioactive Fallout: Hanford's Radioactive Iodine Releases ( ), Are There Observable Health Effects: Allen B. Benson. Health Physics, Vol. 58, No. 2, p. 216, Gerber, A.R., Englender, S.J., Selvey, D., Carlson, J.F., Matthews, D.L., Webster, H.M., Caldwell, G.G. An Outbreak of Non-A, Non-B Hepatitis Associated with the Infusion of a Commercial Factor IX Complex During Cardiovascular Surgery. Vox Sanguinis, 58: , 1990.

217 Publications (continued) Caldwell, G.G. Book Review. Deadly Deceit: Low-Level Radiation, High-Level Cover-up. JAMA 265:523, January Caldwell, G.G. Book Review. Radioactive Heaven and Earth. The Health and Environmental Effects of Nuclear Weapons Testing, In On and Above the Earth. Report of the International Physicians for Prevention of Nuclear War Commission. JAMA 267:431, January 15, Aickin, M., Chapin, C.A., Flood, T.J., Englender, S.J., Caldwell, G.G. Assessment of the Spatial Occurrence of Childhood Leukemia Mortality Using Standardized Rate Ratios with a Simple Linear Poisson Model. International Journal of Epidemiology, 1992; 21: Caldwell, G.G. Book Review. Chemical Alert: A Community Action Handbook. JAMA. 271: 405, Heath, C.W., Jr. and Caldwell, G.G.: Animal Malignancies and Their Relationship to Public Health. Beran,G.W. (ed), Handbook of Zoonoses, Vol. II, 2nd edition, CRC Press, Inc., Boca Raton, Florida Caldwell, G.G., Lee, J., Hammarsten, J.A., Cox, J., Hicks, P.: Tuberculosis in a Tulsa High School. J. Ok. State Med. Assn. 87:56-58, Caldwell, G.G., Cox, J., and Rask, P. Health Handbook for Child Care Settings. Guidelines for Child Care Providers. Tulsa City-County Health Department Caldwell, G.G. Book Review. A-Bomb Radiation Effects Digest. JAMA Caldwell, G.G., Fiegel,D., Bryant,L., Chambers, D., Rask,P. Shigella in Tulsa County, 1993: Epidemiology Day Care Center Association and Control, Shigella in Tulsa County Day Care Center Associated Outbreaks, J. Ok. State Med. Assn. 88: , Caldwell, G.G., Berg, P., Pritchard, C., and Lewis, J.N. Improvement in the Utilization of Left Ventricular Ejection Fraction Measurement and Discharge Planning in Participating Kentucky Hospitals. Heart Failure 14:28-30, Caldwell, G.G., Berg, P., Pritchard, C., and Lewis, J.N. Quality Improvement in the Diagnosis and Treatment of Heart Failure by Participating Indiana and Kentucky Hospitals. Evaluation and the Health Professions 21: , Caldwell, G.G. Book Review. The Woman Who Knew Too Much: Alice Stewart and the Secrets of Radiation. JAMA 287: , 2002.

218 Publications (continued) Fritsch, T.A., Tarima, S. S., Caldwell, G. G., Beaven, S. Intimate Partner Violence Against Older Women in Kentucky. Journal of the Kentucky Medical Association, 2005;103: Publications (continued) Fritsch, T.A., Tarima, S. S., Caldwell, G. G., Beaven, S. Intimate Partner Violence Against Kentucky Women: Prevalence and Health Consequences. Journal of the Kentucky Medical Association, 2005;103: Fritsch TA, Tarima SS, Caldwell GG, and Beaven S. Population-based Surveillance of Intimate Partner Violence Against Kentucky Women: A Comparison of State and National Definitions and Findings. Kentucky Epidemiological Notes and Reports. KY Frankfort: Kentucky Cabinet for Health and Family Services, Department for Public Health; March Tackett, Julie, Charnigo, Richard, and Caldwell, Glyn. Relating West Nile Virus Case Fatality Rates to Demographic and Surveillance Variables. Press Public Health Reports, 2006;121: Walsh, Sabrina, Mark Dignan, and Glyn Caldwell. The PAPM Diffusion Theory and Violent Death Surveillance. American Journal of Health Behavior, 2007;31: Jennifer R. Olges, Brian S. Murphy, Glyn G. Caldwell, Alice C. Thornton. Testing Practices and Knowledge of HIV Among Prenatal Care Providers in a Low Seroprevalence State. AIDS Patient Care and STDs. 2007, 21: Linet, Martha S., Mary K. Schubauer-Berigan, Dennis D. Weisenburger, David B. Richarson, Ola Landgren, Aaron Blair, Sharon Silver, R. William Field, Glyn Caldwell, Maureen Hatch, and Graça M.Dores. Chronic Lymphyocytic Leukemia: An Overview of Etiology in Light of Recent Developments in Classification and Pathogenesis. British Journal of Haematology, in press August, Murphy, Brian S., Orlandi, Palmer A., Caldwell, Glyn G., and Ribes, Julie A. Detection of Microsporidia and Other Parasite Infections in Haitian Children Being Treated for Malnutrition. Submitted to Emerging Infectious Diseases. McLay, Carol, Steve Fleming, Brent Shelton, and Glyn G. Caldwell. A Prolonged Outbreak of Daycare Associated Shigella sonnei: A Case Control Study. Submitted to the American Journal of Epidemiology. Caldwell, Glyn and Steven Fleming. Chapter 2. Infectious Disease Epidemiology for Managers. In Steven T. Fleming, Managerial Epidemiology, ed. 2. In press, 2007.

219 Curriculum Vitae Date Prepared: October 29, 2005 I. General Information David M. Mannino, M.D. Associate Professor of Medicine (Regular Series, Tenure Track) University of Kentucky Medical Center Home Address: 1200 Birmingham Lane, Lexington, KY, Home Telephone: Office Address: 800 Rose Street, MN 614, Lexington, KY, Office Telephone: Office FAX: Social Security Number: (Available on request) Birthdate: April 4, 1958 Certification: American Board of Internal Medicine, 1984 ABIM, Pulmonary Medicine, 1990, 2000 NIOSH B Reader, 1991 Medical Licensure: By examination 1982 Pennsylvania MD E By reciprocity 1984 Kentucky West Virginia Georgia Military Status: United States Public Health Service (retired, Captain) Marital Status: Married Spouse Name: Brenda Peters Mannino II. Education B.S (Science) The Pennsylvania State University, State College, Pennsylvania M.D (Medicine) Jefferson Medical College, Philadelphia, Pennsylvania Internship, Internal Medicine Lankenau Hospital, Philadelphia, Pennsylvania Residency, Internal Medicine Lankenau Hospital, Philadelphia, Pennsylvania Fellowship, Pulmonary Medicine West Virginia University School of Medicine/ National Institute for Occupational Safety and Health (NIOSH); Morgantown, WV III. Professional Experiences DM Mannino Page 1 of 16 7/10/2008

220 IV Medical Staff Officer, Federal Correctional Institution, Lexington, KY Medical Officer, Clinical Investigations Branch, Division of Respiratory Disease Studies (DRDS), NIOSH, Morgantown, WV Pulmonologist/Medical Epidemiologist, Air Pollution and Respiratory Health Activity, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA Section Chief, Analytic Epidemiology Section, Air Pollution and Respiratory Health Activity, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 2004-present Clinician/Scientist, University of Kentucky Medical Center, Division of Pulmonary and Critical Care Medicine, Lexington, KY 2004-present Director, Pulmonary Epidemiology Research Laboratory (PERL), University of Kentucky Medical Center, Division of Pulmonary and Critical Care Medicine, Lexington, KY Academic Appointments Clinical Assistant Professor, Department of Medicine, University of Kentucky, Lexington, KY Adjunct Instructor, Pulmonary and Critical Care Section, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV Adjunct Assistant Professor in the Division of Environmental and Occupational Health, Emory University School of Public Health, Atlanta, GA Clinical Instructor in Medicine, Pulmonary Division, Emory University School of Medicine, Atlanta, GA Clinical Professor of Medicine, Pulmonary Division, Emory University School of Medicine, Atlanta, GA 2004-present Associate Professor of Medicine, University of Kentucky Medical Center, Division of Pulmonary, Critical Care and Sleep Medicine, Lexington, KY V. Hospital Appointments Veterans Administration Medical Center, Lexington, KY, Part-time West Virginia University School of Medicine Hospital, Morgantown, WV, Full-time Veterans Administration Medical Center, Atlanta, GA, Part-time 2004-present University of Kentucky Medical Center, Lexington, KY, Full-time VI. Consultative Service International World Health Organization, Environmental Tobacco Smoke Workshop, May 2000 World Health Organization, Chronic Respiratory Disease Workshop, June 2004 Burden of Lung Disease Project, present National National Lung Health Education Program, 1999-present DM Mannino Page 2 of 16 7/10/2008

221 USCOPD Coalition, 2001-present VII. Teaching Activities Emory University Pulmonary Fellows Lecture Series Epidemiology, Creating a Research Agenda, COPD, Cadmium and the Lung Emory University Summer Pulmonary Course, 2003 Epidemiology of COPD, Environmental Tobacco Smoke Exposure University of Georgia, Air Pollution in the Developed World American College of Chest Physicians, Pulmonary and Critical Care Update, 2003 COPD in the Never Smoker American College of Chest Physicians COPD Mortality That was Then, This is Now, VIII. Advising Activities Provided guidance and mentorship to 1-3 students, residents, or fellows per year who would rotate through CDC s training programs. Many of these resulted in publications (please see publication list underlined names are students, residents or fellows that I have mentored.) IX. Administrative Activities Section Leader, Air Pollution and Respiratory Health Branch, Responsible for leading team of 6 scientists in analysis and reporting of data. Scientific Director, Air Pollution and Respiratory Health Branch, Responsible for scientific oversight in Branch of 40 scientists and public health workers. X. Special Assignments NCEH representative to the CDC internal working group investigating the relationship between mold exposure and pulmonary hemorrhage in children. XI. Honors and Awards USPHS Awards: Meritorious Service Medal For an exemplary career in the USPHS Commendation, For development of CDC Surveillance Summary on Asthma Unit Commendation, For work on task force investigating 1995 cigarette recall DM Mannino Page 3 of 16 7/10/2008

222 Commendation, For exemplary leadership in increasing public awareness of dangers of environmental tobacco smoke exposure Commendation, For exemplary work demonstrating the association between smoking and sexual dysfunction in men Outstanding Unit Citation, For work on task force investigating health effects related to fuel exposures Unit Commendation, For work on respirator testing program Citation, USPHS, For working to enact a Clean Indoor Air ordinance in a community Achievement Award, USPHS, For exemplary performance of clinical duties Other Awards: Soffer Research Award, American College of Chest Physicians, 2003 ( for best scientific abstract at scientific meeting) Advocate of the Year, American Lung Association, 2003 (for work on smoking ordinance in DeKalb County, Georgia) DuPont Young Investigator Award, American College of Chest Physicians, 1994 (for work examining the health effects of environmental tobacco smoke exposure in children) Affiliates Forum, American College of Chest Physicians, 1989 (for work on hypersensitivity pneumonitis) XII. Professional Activity and Public Services American College of Chest Physicians, fellow Chair of Environmental and Occupational Health Section American Thoracic Society, member Georgia Thoracic Society, member European Respiratory Society, member American Lung Association National Action Panel, member COPD Foundation, board member XII. Speaking Engagements International 2002, Malaysian Health Ministry, Health Effects of Air Pollutants 2004, World Health Organization, Assessing COPD in the General Population National 2002, American Thoracic Society, Using Federal Data in your Research 2002, American Thoracic Society, Health Effects of Tobacco Smoke 2003, American Thoracic Society, Epidemiology of COPD 2003, American College of Chest Physicians, Epidemiology of COPD DM Mannino Page 4 of 16 7/10/2008

223 Local 2004, American Thoracic Society, Epidemiology of COPD 2002, University of Nebraska, Cadmium and the Lung XIV. Research and/or Scholarship Publications (Peer-reviewed) 1. Mannino DM, Kennedy RD, Hodous TK. Classification of radiographs for pneumoconiosis: A comparison of digitized images and conventional film images. Radiology 1993;187: Mannino DM, Etzel RA, Flanders WD. Do the medical history or physical examination predict low lung function? Arch Intern Med 1993; 153: Mannino DM, Klevens RM, Flanders WD. Cigarette Smoking: An independent risk factor for impotence? Am J Epidemiol 1994;140; Sinks T, Hartle R, Boeniger M, Mannino D, Boyd J, Fernback J, Hawkins M, Grimes G, Watkins K, Dill P, Anderson B. Exposure to biogenic silica fibers and respiratory health in Hawaii sugarcane workers. J Occ Med 1994;36: Mannino DM, Schreiber J, Aldous K, Moolenaar R, Almaguer D. Human exposure to volatile organic compounds: a comparison of organic vapor monitoring badge levels with blood levels. Internat Arch Occupat Environ Health 1995;67: Petsonk EL, Daniloff EM, Mannino DM, Wang ML, Short SR, Wagner GR. Airway responsiveness and job selection: a study in coal miners and non-mining controls. Occupat Environ Med 1995;52: Mannino DM, Etzel RA. Are oxygenated fuels effective? An evaluation of ambient carbon monoxide concentrations in 11 western states, 1986 to J Air and Waste Management Association 1996; 46: Hanrahan JP, Sherman CB, Bresnitz EA, Emmons KM, Mannino DM. Cigarette smoking and health. Am J Respir Crit Care Med 1996;153: Mannino DM, Ruben SM, Holschuh FC, Holschuh TC, Wilson MD, Holschuh T. Emergency department visits and hospitalizations for respiratory disease on the Island of Hawaii, : Annual trends on the Island of Hawaii and Weekly Variability in Hilo, Hawaii. Hawaii Med J 1996;55: Gideon NM, Mannino DM. Sarcoidosis deaths in the United States, : an analysis of multiple-cause mortality data. Am J Med 1996;100: DM Mannino Page 5 of 16 7/10/2008

224 11. Mannino DM, Siegel M, Husten C, Rose DA, Etzel RA. Environmental tobacco smoke exposure and health effects in children: results from the 1991 National Health Interview Survey. Tobacco Control 1996;5: Wells C, Mannino DM. Pulmonary fibrosis and lung cancer in the United States: an analysis of the multiple cause mortality data, Southern Med J 1996;89: Mannino DM, Etzel RA, Parrish RG. Pulmonary fibrosis deaths in the United States, : an analysis of multiple-cause mortality data. Amer J Respir Crit Care Med 1996;153: Mannino D, Geiss R, Hodous T, Lapp NL. Hypersensitivity pneumonitis following exposure to biologic mold inhibitor and forage inoculant. Southern Med J 1996;89: Browne RA, Mannino DM, Khoury MC. Alpha-1 antitrypsin deficiency deaths in the United States, : an analysis of multiple-cause mortality data. Chest 1996;110: Haliburton CH. Mannino DM, Olney RE. Cystic fibrosis deaths in the United States, : an analysis of multiple-cause mortality data. Archives of Pediatric and Adolescent Medicine 1996;150: Mannino DM, Brown C, Giovino GA. Obstructive lung disease deaths in the United States from 1979 through 1993: an analysis using multiple-cause mortality data. Amer J Respir Crit Care Med 1997;156: Fisher CL, Mannino DM, Herman WH, Frumkin H. Cigarette smoking and thyroid hormone levels in males. Internat J Epidemiol 1997;26: Yang Q, Khoury MJ, Mannino DM. Trends and patterns of mortality associated with birth defects and genetic diseases in the United States, : An analysis of multiple-cause mortality data. Genetic Epidemiol 1997; 14: Mannino DM, Siegel M, Rose D, Nkuchia J, Etzel RA. Environmental Tobacco Smoke Exposure and Health Effects in Adults: Results from the 1991 National Health Interview Survey. Tobacco Control 1997; 6: Mannino DM, Homa D, Pertowski C, Ashizawa A, Nixon L, Johnson CA, Ball L, Jack E, Kang D. Surveillance for Asthma- United States, In: CDC Surveillance Summaries, April 24, 1998 MMWR 1998;47(No. SS1): Mannino DM, Ford E, Giovino GA, Thun M. Lung cancer deaths in the United States from 1979 through 1992: an analysis using multiple-cause mortality data. Internat J Epidemiol 1998;27: Phillips D, Phillips B, Mannino DM. A case study and national database report of systemic DM Mannino Page 6 of 16 7/10/2008

225 sclerosis and associated conditions. J Women s Health 1998;7: Chen J, Mannino DM. Worldwide Epidemiology of Chronic Obstructive Pulmonary Disease. Current Opinion in Pulmonary Medicine 1999; 5: Homa DM, Mannino DM, Lara M Asthma Mortality in U.S. Hispanics of Mexican, Puerto Rican and Cuban Heritage, Amer J Respir Crit Care Med 2000; 161: Mannino DM, Gagnon RC, Petty TL, Lydick E. Obstructive Lung Disease and Low Lung Function in Adults in the United States: Data from the National Health and Nutrition Examination Survey, Arch Internal Med 2000; 160: Mannino DM. How much asthma is occupationally related? Occup Med State of the Art Review 2000; 15: Mannino DM, Moorman JE, Kingsley B, Rose D, Repace J. Health Effects Related to Environmental Tobacco Smoke Exposure in Children in the United States: Data from the National Health and Nutrition Examination Survey, Archives of Ped Adolescent Med 2001;155: Mannino DM, Ford E, Giovino GA, Thun M. Lung Cancer Mortality Rates in Birth Cohorts in the United States from 1960 Through Lung Cancer 2001;31: Moorman JE, Mannino DM. Asthma: Who is really dying? J Asthma 2001;38: TenHoor T, Mannino DM, Moss M. Risk factors for acute respiratory distress syndrome in the United States: Analysis of the 1993 National Mortality Followback Study Chest 2001;119: Wilson SR, Yamada EG, Sudhakar R, Roberto L, Mannino D, Meja C, Huss N, Springer P. A controlled trial of an ETS reduction intervention in low-income children with asthma. Chest 2001;120: Mannino DM, Caraballo R, Benowitz N, Repace J. Predictors of Cotinine Levels in US Children: Data from the Third National Health and Nutrition Examination Survey. Chest 2001;120: Stevenson LA, Gergen PJ, Hoover DR, Rosenstreich D, Mannino DM, Matte TD. Sociodemographic correlates of indoor allergen senstivity among United States children. J Allergy Clin Immunol 2001;108: Mott JA, Meyer P, Mannino D, Redd SC, Smith EM, Gotway-Crawford C, Chase E. Wildland forest fire smoke:health effects and intervention evaluation, Hoopa, California, Western J Med 2002;176: DM Mannino Page 7 of 16 7/10/2008

226 36. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for Asthma B United States, In: Surveillance Summaries, March 29, MMWR 2002;51 (No. SS-1). 37. Homa DM, Mannino DM, Redd SC.Regional differences in hospitalizations for asthma in the United States, J Asthma 2002;39: Mannino DM. COPD Epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002;121: 121S-130S. 39. Moss M, Mannino DM. Racial and Gender differences in ARDS deaths in the US: An analysis of Multiple-cause mortality data ( ). Crit Care Med 2002 August;30(8): Mott JA, Wolfe MI, Alverson CJ, Macdonald S, Baily, CR, Ball LB, Moorman J, Somers JH, Mannino D, Redd SC. National vehicle emissions policies and practices and declining carbon monoxide-related mortality in the United States, 1968 to Journal of the American Medical Association 2002; 288: Meyer PA, Mannino DM, Redd SC, Olson DR. Characteristics of Adults Dying with Chronic Obstructive Pulmonary Disease. Chest 2002; 122: Mannino DM, Homa DM, Redd SC. Involuntary smoking and asthma severity in children: Data from the Third National Health and Nutrition Examination Survey. Chest 2002; 122: Ford ES, Gillespie C, Ballew C, Sowell A, Mannino DM. Serum carotenoid concentrations in US children and adolescents. American Journal of Clinical Nutrition 2002; 76: Mannino DM, Homa DM, Akinbami LJ, Ford EA, Redd SC. Surveillance for Chronic Obstructive Pulmonary Disease B United States, MMWR 2002;51(No. SS-6). 45. Ford ES, Mannino DM, Homa DM, Gwynn C, Redd SC, Moriarty DG. Mokdad AH. Self- Reported Asthma and Health-Related Quality of Life. Findings From the Behavioral Risk Factor Surveillance System. Chest 2003;123: Martin GS, Mannino DM, Eaton S, Moss M. Epidemiology of Sepsis in the United States: Incidence, Demographics, and Outcomes from New Engl J Med 2003; 348: Ford ES, Mannino DM, Redd SC, Mokdad AH, Galuska DA, Serdula MK. Weight-loss practices and asthma: findings from the behavioral risk factor surveillance system. Obesity Research. 2003; 11:81-86 DM Mannino Page 8 of 16 7/10/2008

227 48. Ford ES, Giles WH, Myers GL, Mannino DM. Population distribution of high-sensitivity C-reactive protein among US men: findings from National Health and Nutrition Examination Survey Clinical Chemistry. 2003; 49: Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC. Lung Function and Mortality in the United States: Data from the First National Health and Nutrition Examination Survey Follow-Up. Thorax 2003; 58: Mannino DM, Mulinare J, Schwartz J, Redd SC. Tobacco smoke exposure and decreased serum and red blood cell folate levels: Data from the Third National Health and Nutrition Examination Survey. Nicotine and Tobacco Research 2003;5: Mannino DM, Aguayo SM, Petty TL, Redd SC. Low lung function and incident lung cancer in the United States: Data from the First National Health and Nutrition Examination Survey Follow-Up. Arch Intern Med. 2003;163: Horlander KT, Mannino DM, Leeper KV. Pulmonary Embolism Mortality in the United States : An Analysis Using Multiple Cause Mortality Data. Arch Intern Med. 2003; 163: Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB. The proportional Venn diagram of obstructive lung disease: two approximations from the US and the UK. Chest 2003; 124: Mannino DM, Ford ES, Redd SC. Obstructive and restrictive lung disease and markers of inflammation: Data from the Third National Health and Nutrition Examination Survey. Am J Med, 2003;114: Ford ES, Heath GW, Mannino DM, Redd SC. Leisure-time physical activity patterns among US adults with asthma. Chest 2003; 124: Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr 2003;57: Ford ES, Mannino DM, Williams SG. Asthma and influenza vaccination: Findings from the National Health Interview Surveys. Chest 2003 ;124: Foreman MG, Mannino DM, Moss M. Cirrhosis as a risk factor for sepsis and death: analysis of the National Hospital Discharge Survey. Chest 2003;124: Holguin F, Tellez-Rojo MM, Hernandez M, Cortez M, Chow JC, Watson JG, Mannino D, Romieu I. Air Pollution and Heart Rate Variability Among the Elderly in Mexico City. Epidemiology 2003; 14: DM Mannino Page 9 of 16 7/10/2008

228 60. Mannino DM, Albalek R, Grosse S. Second-hand smoke exposure and blood lead levels in U.S. children: Data from the Third National Health and Nutrition Examination Survey. Epidemiology, 2003;14: Mannino DM, Ford ES, Redd SC. Obstructive and Restrictive Lung Disease and Functional Limitation: Data from the Third National Health and Nutrition Examination. J Intern Med 2003; 254: Mannino DM. Chronic obstructive pulmonary disease: definition and epidemiology. Respir Care Dec;48(12): Mannino DM, Holguin F, Greves HM, Brown AS, Stock AL, Jones RL. Urinary cadmium predicts lower lung function in current and former smokers: Data from the Third National Health and Nutrition Examination Survey. Thorax 2004; 59: Kazerouni N, Alverson CJ, Redd SC, Mott JA, Mannino DM. Sex differences in COPD and lung cancer mortality trends United States, J Women s Health 2004; 13: Ford ES, Mannino DM, Redd SC. Serum Antioxidant Concentrations Among U.S. Adults with Self-Reported Asthma. J Asthma 2004;41: Ford ES, Williams SG, Mannino DM, Redd SC. Low influenza vaccination rates among adults with asthma: findings from the 2001 Behavioral Risk Factor Surveillance System. Am J Med 2004;116: Romieu I, Mannino DM, Redd SC, McGeehin MA. Dietary intake, physical activity, body mass index and childhood asthma in the Third National Health and Nutrition Survey (NHANES III). Ped Pulmonology 2004 ;38: Sin DD, Jones RL, Mannino DM, Man SFP. The Relationship Between FEV 1 And Physical Activity Participation In The General Population. Am J Med 2004;117: Ford ES, Mannino DM, Redd SC, Moriarty DG, Mokdad AH. Determinants of quality of life among people with asthma: Findings from the Behavioral Risk Factor Surveillance System. J Asthma 2004;41: King MS, Mannino DM, Holguin F. Risk factors for asthma incidence: a review of recent prospective evidence. Panminerva Med 2004;46: Ford ES, Mannino DM, Redd SC, Mokdad AH, Mott JA. Body mass index and asthma incidence among USA adults. Eur Respir J ; 24: Ford ES, Mannino DM. Prospective association between lung function and the incidence of diabetes: Findings from the National Health and Nutrition Examination Survey DM Mannino Page 10 of 16 7/10/2008

229 Epidemiologic Follow-Up Study. Diabetes Care 2004; 27: Holguin F, Mannino DM, Anto J, Mott J, Ford ES, Teague WG, Redd SC, Romieu I. Country of Birth as a Risk Factor for Asthma Among Mexican Americans. Amer J Respir Crit Care Med ;171: Holguin F, Tellez-Rojo MM, Lazo M, Mannino DM, Schwartz J, Hernandez M, Romieu I. Cardiac Autonomic Changes Associated with fish vs. soy oil supplementation in the elderly. Chest 2005; 127: Kelley CF, Mannino DM, Homa DM, Brown AS, Holguin F. Asthma Phenotypes, Risk Factors, and Measures of Severity in a National Sample of U.S. Children. Pediatrics 2005 Mar;115: Ford ES, Mannino DM. Time trends in obesity among adults with asthma in the United States: findings from three national surveys. J Asthma. 2005; 42: Mannino DM, Holguin F, Pavlin BI, Ferdinands JM. Risk Factors for Prevalence of and Mortality Related to Restriction on Spirometry: Findings from the First National Health and Nutrition Examination Survey and Follow-up. Int J Tuber Lung Dis 2005;9: Mott JA, Mannino DM, Alverson CJ, Kiyu A, Hashim J, Lee T, Falter K, Redd SC. Cardiorespiratory hospitalizations associated with smoke exposure during the 1997 Southeast Asian forest fires. Int J Hygiene Env Health 2005; 208: Mannino DM, Homa DM, Matte T, Hernandez-Avila M. Active and passive smoking and blood lead levels in U.S. adults: Data from the Third National Health and Nutrition Examination Survey. Nicotine and Tobacco Research 2005; 7: Phillips B, Mannino DM. Correlates of Sleep Complaints in Adults: The ARIC study. J Clin Sleep Med. 2005;1: Phillips B, Mannino DM. Does Insomnia Kill? Sleep 2005; 28: Savage-Brown A, Mannino DM, Redd SC. Obstructive and Restrictive Lung Disease and Asthma Severity in Adults with Asthma: Data from the Third National Health and Nutrition Examination. J Asthma 2005; 42: Holguin F, Mannino DM, Redd SC. Comorbidity and Mortality in Chronic Obstructive Pulmonary Disease-related Hospitalizations United States, Chest 2005; 128: Sisson JH, Stoner JA, Romberger DJ, Spurzem JR, Wyatt TA, Owens-Ream J, Mannino DM. Alcohol Intake is Associated with Altered Pulmonary Function. Alcohol 2005; 36: DM Mannino Page 11 of 16 7/10/2008

230 85. Rose D, Mannino DM, Leaderer B. Asthma prevalence in U.S. adults, : Puerto Rican ethnicity, behavioral and environmental factors. Am J Public Health. ( in press 3 05) 86. Mannino DM, Doherty DE, Buist AS. Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study. Resp Med (in press 3 05) 87. Mannino DM, Watt G, Hole D, Gillis C, Hart C, McCormachie A, Smith GD, Upton M, Hawthorne V, Sin DD, Man SFP, Van Eeden S, Mapel DW, Vestbo J. The Global Burden of COPD: The Natural History of COPD. Eur Resp J ( in press 3 05). 88. Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Thun MJ, Connell C, Jernal A, Buist AS, Lee TA, Miravitlles M, Hansell AL, Held LS, Schmid V, Aldington S, Beasley R, Lopez AD, Shibuya K, Rao C, Mathers CD. Research Workshop on the Global Burden of COPD. Vancouver, October PART I. Eur Resp J ( in press 3 05). 89. Mannino DM, Mott J, Morris JM, Camargo CA, Friedman M, Greves HM, Redd SC. Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY) Int J Obesity (In Press 9 05). 90. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of sepsis. In review at Crit Care Med (submitted 11/04) 91. Nurmagambetov T, Atherly A, Williams S, Holguin F, Redd SC, Mannino DM. What is the cost of chronic obstructive pulmonary disease to employers? COPD (in review ) 92. Danai PA, Moss M, Mannino DM, Martin GM. The epidemiology of sepsis in patients with malignancy. Chest (in review ) 93. Phillips B, Hening W, Britz P, Mannino D. Prevalence and correlates of restless legs syndrome: Results from the 2005 National Sleep Foundation poll. Chest (in Press ) 94. Jones SE, Merkle S, Wheeler L, Mannino DM, Crosset L. Drug Use among High School Students with Asthma. JAMA (in review ). 95. Mannino DM, Reichert MM, Davis KJ. Lung function decline and outcomes in an adult population followed for up to eleven years. Am J Respir Crit Care Med (in review 9 05) 96. Mannino DM, Davis KJ. Lung function decline and outcomes in an elderly population. Thorax (in review 9 05). 97. Esper AM, Moss M, Lewis CA, Nisbet R, Mannino DM, Martin GS. The Role of Infection and Co-Morbidity: Factors that Influence Disparities in Sepsis. Crit Care Med (In review 10 05) DM Mannino Page 12 of 16 7/10/2008

231 Publications (Non-peer-reviewed) 1. Mannino DM, Petsonk EL, Daniloff EM, Townsend MC. Are atopic symptoms associated with increased airway responsiveness in coal miners? Proceedings of the Third Symposium on Respirable Dust in the Mineral Industry, 1992, Chapter 19, Mannino DM. Chronic obstructive pulmonary disease: epidemiology and evaluation. Hospital Physician 2001; 37 (10): Meyer P, Mannino D, Homa D, Naeher L, Redd S. Every breath we take. Forum for Applied Research and Public Policy 1999; Meyer P, Mannino D, Redd S. Air Pollution: What the Georgia physician should know. J Med Association of Georgia 1999;88:Vol Mannino DM. Epidemiology and Global Impact of Chronic Obstructive Pulmonary Disease. Seminars in Respiratory and Critical Care Medicine 2005;26: Book Chapters 1. Mannino DM, Etzel RA. A review of epidemiologic evidence of human health effects related to power plant-generated air pollution. In Environmental Contaminants, Ecosystems and Human Health. Edited by S.K. Majumdar, E.W. Miller, and Fred J. Brenner, 1995, The Pennsylvania Academy of Science pp Letters, Editorials, Book Reviews 1. Johnson CA, Mannino DM, Ashizawa A. Asthma mortality in United States has risen but is similar to that in England and Wales. Brit Med J 1997; 315: (letter) 2. Mannino DM. Measuring asthma, respiratory symptoms, and changes over time. Int J Tuber Lung Dis 2004; 8:1395. (editorial) 3. Mannino DM. Impact Factor, Impact, and Smoke and Mirrors. Amer J Respir Crit Care Med 2005 ;171: (letter) DM Mannino Page 13 of 16 7/10/2008

232 4. Mannino D. Chronic Obstructive Pulmonary Disease in 2025 Where are We Headed? Eur Resp J 2005; 26:189 (editorial) 5. Mannino DM. Heaso Cheonsik and Chronic Obstructive Pulmonary Disease in Korea. Amer J Respir Crit Care Med 2005; 172: (editorial) Grant Activity R01 HL Wilson (PI) 5/2002-5/2007 NHLBI This study seeks better asthma outcomes in children by lowering tobacco smoke exposure Role Co-investigator 5 years of funding, $400,000 (estimated) direct costs, $0 available to D. Mannino Glaxo-Smith Kline Mannino (PI) 8/2004-8/2005 This study will look at the effect of impaired lung function on long-term follow-up of subjects in large population-based studies Role Principle investigator 1 year of funding $150,000 direct costs, $150,000 available to PI Pfizer Mannino (PI) 1/2005-1/2006 This study will look at utility of spirometry in a managed care setting to improve the care and outcomes of patients in the general population and those with chronic respiratory disease. 1 year of funding $150,000 direct costs, $150,000 available to PI Centers for Disease Control and Prevention Cohen (PI) 10/2004-9/2009 The Marty Driesler Cancer Project: Early Detection of Lung Cancer in a High Risk Population Defined by Pulmonary Function Testing, Biomarkers, and Computed Tomogaphy The primary goals of this study are to: 1) develop the infrastructure and institutional partnerships to conduct high quality population-based clinical epidemiological studies in the 5 th Congressional District of Kentucky, 2) implement the International Burden of Lung Disease study in the 5 th Congressional District of Kentucky, 3) perform a CT cohort screening study in the 5 th Congressional District of Kentucky to detect early stage lung cancer among patients at high-risk (defined by pulmonary function tests and stringent tobacco exposure) of having (prevalence screen) or developing incident lung cancer during the study period, and 4) collect the biological specimens necessary for the discovery and further development of selected biomarkers for the risk assessment, early detection, diagnosis, prognosis, and treatment of lung cancer using phase II case-control, phase III nested case-control, and phase IV cohort study designs. Role Co PI Year 1 of funding - $600,000 available to project Research Projects Health Effects Related to Tobacco Smoke Metals and the Lung DM Mannino Page 14 of 16 7/10/2008

233 Outcomes and Comorbidities of COPD Talks (2005) 1 2/18/05 The Epidemiology of COPD Miami, Speakers Bureau Training 2. 4/15/05 Environmental Tobacco Smoke in What the Internist Needs to Know Lexington, Medical Grand Rounds 3. 3/17/05, 3/22/05, 4/20/05, 4/21/05 - COPD Evolving Concepts of Therapy Louisville, Cincinnati, Cleveland -Pfizer/Boehringer Speaker s Bureau 4. 4/26/05 Chronic Obstructive Lung Diseases -Clinical Correlation Lexington, KY Physiology Class 5. 4/22/05 Lung Cancer Risk Factors Lexington, KY, (Lung Cancer Conference) 6. 5/18/05 The Burden and Changing Face of COPD La Jolla, Ca. (GSK Advisory Board) 7. 5/20/05 COPD- Impact and Epidemiologic Insights San Diego, Ca (American Thoracic Society, Post Graduate Session) 8. 5/22/05 Are Women Really More Likely to Develop COPD than Men? San Diego, Ca. (American Thoracic Society Symposium) 9. 5/22/05 COPD Trends, Myths and Challenges San Diego, Ca (American Thoracic Society, Evening Session) 10. 5/23/05 Risk Stratification: Defining Populations for Lung Cancer Screening and Intervention San Diego, Ca (American Thoracic Society, Symposium) 11. 5/24/05 COPD Progression: Epidemiologic Issues San Diego, Ca (American Thoracic Society, Symposium) 12. 9/20/05 Environmental Tobacco Smoke Exposure and COPD Exacerbations Copenhagen, Denmark (European Respiratory Society, Symposium) 13. 9/28/05 Lung Function as a Biomarker for Lung Cancer Lexington, Ky (College of Public Health) /27/05 Alpha-1 Antitrypsin Deficiency Louisville, Ky (Louisville Cardiovascular and Pulmonary Summit) /4/05 Secondhand smoke: What the general practitioner needs to know Lexington, KY (Kentucky Rural Health Association) DM Mannino Page 15 of 16 7/10/2008

234 16. 11/15/05 COPD epidemiology, diagnosis and outcomes, COPD- risk factors, treatment and prevention, Asthma as a public health problem Slade, KY (Kentucky River Health District Symposium) /17/05 COPD in Women Louisville, KY (American Lung Association State Conference) XV. Other Reviewer - Chest, Thorax, American Journal of Respiratory and Critical Care Medicine, New England Journal of Medicine, Lancet, JAMA, Respiratory Medicine, International Journal of Tuberculosis and Lung Disease, Nicotine and Tobacco Research DM Mannino Page 16 of 16 7/10/2008

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236 Andre T. Baron Date Revised: 4/1/2008 atb 2005-present Member, University of Kentucky, Markey Cancer Center, Biospecimens Bioinformatics Core Steering Committee 2004-present Member, University of Kentucky, Markey Cancer Center, Marty Driesler Cancer Program, Executive Committee 2004 Faculty, Marsha Rivkin Center of Ovarian Cancer Research, 5 th Biennial Ovarian Cancer Research Symposium: Emerging Controversies in Ovarian Cancer Research & Treatment, Seattle, Washington 2004-present Ad-hoc Consultant, University of Kentucky, Markey Cancer Center, Scientific Review Committee 2004-present Associate Member, Graduate Faculty, University of Kentucky, College of Public Health 2004 Ad-hoc Consultant, National Cancer Institute, Special Emphasis Peer Review Panel, Small Business Innovation Research Grants entitled Antibody Array for Cancer Detection 2004-present Alternate Member, Nebraska Cancer and Smoking Disease Research Program Peer Review Panel, Nebraska Health and Human Services System Member, Organizing Committee, University of Kentucky, Symposium entitled The Relationship of Tobacco and HPV with Lung, Head & Neck, and Cervical Cancer 2003-present Member, University of Kentucky, Gastrointestinal Cancer Clinical Care and Research Team 2003-present Member, University of Kentucky, Lung Cancer Clinical Care and Research Team 2003-present Member, Steering Committee, University of Kentucky, Multidisciplinary Lung Cancer Program 2003-present Chair, Prevention and Early Detection Working Group, Kentucky Lung Cancer Research Program 2003-present Member, University of Kentucky, Markey Cancer Center 2003-present Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, University of Kentucky, Kentucky College of Public Health 2002 Member, U.S. Army Medical Research and Material Command, Department of Defense, Ovarian Cancer Research Program Peer Review Panel, Cell Biology & Immunology Member, Mayo Clinic Comprehensive Cancer Center Assistant Professor, Department of Biochemistry & Molecular Biology, Mayo Clinic Foundation District Coordinator, Congressional Liaison Committee, The American Society for Cell Biology By-laws Committee, Graduate Student Senate, Case Western Reserve University, Center for Neuroscience Graduate Student Representative, Faculty Council, Case Western Reserve University, School of Medicine Graduate Student Representative, Faculty of Medicine, Case Western Reserve University, School of Medicine 1985 Research Technician for Dr. Jeffrey Salisbury, Case Western Reserve University, School of Medicine, Department of Anatomy and Developmental Genetics Research Technician for Dr. Margaret Clarke, Albert Einstein College of Medicine of Yeshiva University, Department of Molecular Biology Research Technician for Dr. Jeffrey Salisbury, Albert Einstein College of Medicine of Yeshiva University, Department of Anatomy IV. ACADEMIC APPOINTMENTS page 2

237 Andre T. Baron Date Revised: 4/1/2008 atb 2003-present Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, Department of Epidemiology, University of Kentucky (Full-time academic tenure track) Assistant Professor, Department of Biochemistry & Molecular Biology, Mayo Clinic Foundation (Full-time academic non-tenure track) V. CONSULTING ACTIVITIES Local MSPR, 90.3 FM, Health Matters, Interview with Dr. Anthony Weaver, August 23, 2006, The Marty Driesler Cancer Project Lung cancer screening and biomarkers of lung cancer. MSPR, 90.3 FM, Health Matters, Interview with Dr. Anthony Weaver, November 9, 2005, The Marty Driesler lung cancer screening study - Biomarkers of lung cancer. WVLK, 590 AM, Perspectives, Interview with Kendra Steel, July 17, 2005, Monitoring the responsiveness of breast cancer patients to aromatase inhibitors (e.g., letrozole) using the serum biomarker segfr. National Glaser, V., In consultation with A.T. Baron, S.A. Brassell, and L.P. Shulman (2005) Early cancer diagnosis: Present and future. Patient Care, 39: VI. TEACHING ACTIVITIES 2008 Lecturer, Introduction to Clinical Research, University of Kentucky, General Clinical Research Center 2008-present Course Co-Director, BSC 731/BSC /CPH 669, Methods and Technologies in Clinical & Translational Science, University of Kentucky, Graduate Certificate Program in Clinical Translational Research 2007-present Lecturer, CPH 718, Cancer Epidemiology, University of Kentucky, College of Public Health, lecture entitled, Genetic Factors, Tumors Biomarkers, and Cancer 2005-present Lecturer, TOX 680, Advanced Toxicology, University of Kentucky, Graduate School, lecture entitled, Epidemiological Study Design and Data Analysis 2005-present Lecturer, MI/MED/PHA 616, Biology and Therapy of Cancer, University of Kentucky, Graduate School, lecture entitled, Cancer Epidemiology and Pathogenesis 2004-present Course Director, CPH 718, Molecular Epidemiology, Cancer Prevention and Control, University of Kentucky, College of Public Health Instructor, Tumor Biology Program, Mayo Graduate School Laboratory Instructor, Microscopic Anatomy, Mayo Medical School Lecturer, Principles of Cell and Tissue Design, Mayo Graduate School, lecture entitled, Mitosis and Cell Division 1987 Laboratory Instructor, Histology, Case Western Reserve University, School of Medicine Instructor, Neurology and Pathology, Institute for Self Development: Wholistic Health Center 1982 Instructor, Anatomy & Physiology, and Microbiology, The Catholic Medical Center of Brooklyn and Queens, Inc., School of Nursing 1981 Teaching Assistant, Summer Science Camp, Adelphi University page 3

238 Andre T. Baron Date Revised: 4/1/2008 atb Laboratory Teaching Assistant, Comparative Vertebrate Anatomy, Adelphi University VII. ADVISING ACTIVITIES Visiting Faculty Elsa Cora, Ph.D., Mentored Minority Scientist Sabbatical Award, NIH KO1, University of Puerto Rico, School of Medicine Postdoctoral Fellows Jason Wilken, Ph.D., Komen Translational Research Fellowship Award, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, CT 2007-present Hollie Skaggs, Ph.D., Postdoctoral Fellow, Tumor Biology and Molecular Epidemiology, University of Kentucky, KY Clinical Fellows/Residents 2007-present Daniel Haggstrom, M.D., Clinical Fellow, Division of Hematology, Oncology, Blood & Marrow Transplatation, University of Kentucky, KY 2007-present Joseph Haynes, M.D., Resident, Division of Gynecological Oncology, University of Kentucky, KY 2007-present Rachel Ware, M.D., Clinical Fellow, Division of Gynecological Oncology, University of Kentucky, KY 2006-present Brook Saunders, M.D., Clinical Fellow, Division of Gynecological Oncology, University of Kentucky, KY Daniel Metzinger, M.D., Clinical Fellow, Department of Gynecological Surgery, Mayo Clinic Foundation, MN Cecelia Boardman, M.D., Clinical Fellow, Department of Gynecological Surgery, Mayo Clinic Foundation, MN Graduate Students 2007-present Yuxia Oha Wang, Biostatistics Graduate Student, M.P.H., Capstone Committee Member, University of Kentucky, College of Public Health, KY 2007-present Abby Cosentino-Boehm, Epidemiology Graduate Student, DrPh., Field Practicum Advisor and Capstone Committee Chair, University of Kentucky, College of Public Health, KY 2006-present Eric Bensadoun, M.D., Epidemiology Graduate Student, M.P.H., Capstone Committee Member, University of Kentucky, College of Public Heath, KY 2005-present Ellen Rasnake, Epidemiology Graduate Student, DrPh., University of Kentucky, College of Public Heath, KY 2004-present Kimberly Kimbler, Epidemiology Graduate Student, DrPh., University of Kentucky, College of Public Heath, KY 2004-present Mark Coyne, Ph.D., Epidemiology Graduate Student, M.P.H., University of Kentucky, College of Public Heath, KY Medical Students 2007-present Michael E. Haughton, Summer Medical Student Fellow, University of Kentucky, KY Undergraduates 2006 Lyndsey J. Cheuvront, NIH/INBRE/KBRIN P20RR16481 Summer Undergraduate Research Fellow, University of Kentucky, KY Liz Wai Ping Ng, Undergraduate Research Trainee, Mayo Clinic Foundation, MN 1998 Wes Swingley, Undergraduate Research Trainee, Mayo Clinic Foundation, MN page 4

239 Andre T. Baron Date Revised: 4/1/2008 atb Elena Frank, Undergraduate Research Trainee (1998), Summer Undergraduate Research Fellow (1999), Mayo Clinic Foundation, MN 1996 Ayfel Kerimo, Master of Medical Science Candidate, Uppsala University, Sweden 1996 Debra Teo, Summer Undergraduate Research Fellow, Mayo Clinic Foundation, MN 1996 Richard Ashley, Minority Scholar, Mayo Clinic Foundation, MN 1995 Judy Heddens, Undergraduate Research Trainee, Mayo Clinic Foundation, MN Gail Nichols, Summer Undergraduate Research Fellow, Mayo Clinic Foundation, MN Jayleen Grams, Summer Undergraduate Research Fellow (1991), Special Project Associate (1992), Mayo Clinic Foundation, MN 1991 Simone Dundas, M.D. Candidate, Research Fellow, Mayo Clinic Foundation, MN 1989 Joel Drader, Summer Undergraduate Research Fellow, Mayo Clinic Foundation, MN 1988 Tammy Greenwood, Undergraduate Research Trainee, Case Western Reserve University, OH High School Students 2006 Meredith Crutcher, Advanced English 4, Senior Presentation of Laboratory Field Project, Henry Clay High School, KY VIII. ADMINISTRATIVE ACTIVITIES AND UNIVERSITY SERVICE 2005-present Member, Scientific Advisory Committee, University of Kentucky, Markey Cancer Prevention and Control Program 2005-present Member, Biospecimens Core Tissue Bank Steering Committee, University of Kentucky, Markey Cancer Center, 2004-present Member, Executive Committee, University of Kentucky, Markey Cancer Center, Marty Driesler Cancer Program 2004-present Ad-hoc Consultant, Scientific Review Committee, University of Kentucky, Markey Cancer Center 2003-present Member, University of Kentucky, Gastrointestinal Cancer Clinical Care and Research Team 2003-present Member, University of Kentucky, Lung Cancer Clinical Care and Research Team 2003-present Member, Steering Committee, University of Kentucky, Multidisciplinary Lung Cancer Program 2003-present Member, Department of Epidemiology Faculty Committee, University of Kentucky, College of Public Health IX. HONORS AND AWARDS National Institutes of Health / National Cancer Institute, Preventive Oncology Career Development Award, Principal Investigator (KO7 CA 76170, Baron) National Institutes of Health / National Cancer Institute, Multidisciplinary Basic Research Training in Cancer, Postdoctoral Fellow (T23 CA 09441, Getz) X. PROFESSIONAL ACTIVITY AND PUBLIC SERVICE 2007 Member, American Cancer Society, Canary Fund on Special Initiatives Peer Review Commitee, Postdoctoral Fellowship Program in the Early Detection of Cancer page 5

240 Andre T. Baron Date Revised: 4/1/2008 atb 2005 Member, National Cancer Institute, SPORE (Specialized Programs of Research Excellence) Peer Review Panel, Ovarian & Gynecologic Cancers 2005 Member, American Cancer Society, Canary Fund on Special Initiatives Peer Review Commitee, Postdoctoral Fellowship Program in the Early Detection of Cancer 2004 Faculty, Marsha Rivkin Center of Ovarian Cancer Research, 5 th Biennial Ovarian Cancer Research Symposium: Emerging Controversies in Ovarian Cancer Research & Treatment, Seattle, Washington 2004 Ad-hoc Consultant, National Cancer Institute, Special Emphasis Peer Review Panel, Small Business Innovation Research Grants entitled Antibody Array for Cancer Detection 2004 Alternate Member, Nebraska Cancer and Smoking Disease Research Program Peer Review Panel, Nebraska Health and Human Services System Member, Organizing Committee, University of Kentucky, Symposium entitled The Relationship of Tobacco and HPV with Lung, Head & Neck, and Cervical Cancer 2003-present Chair, Prevention and Early Detection Working Group, Kentucky Lung Cancer Research Program 2002 Member, U.S. Army Medical Research and Material Command, Department of Defense, Ovarian Cancer Research Program Peer Review Panel, Cell Biology & Immunology Editorial Responsibilities 2007-present Ad Hoc Reviewer, Clinical Cancer Research 2005-present Ad Hoc Reviewer, Nature Clinical Practice Oncology 2005-present Ad Hoc Reviewer, Molecular Cancer Therapeutics 2005-present Ad Hoc Reviewer, Gynecologic and Obstetric Investigation 2005-present Ad Hoc Reviewer, Cancer Epidemiology Biomarkers & Prevention 1999-present Ad Hoc Reviewer, Gynecologic Oncology 1996-present Ad Hoc Reviewer, The Journal of Cell Biology 1994-present Ad Hoc Reviewer, The Histochemical Journal Professional Affiliations 2005-present American Association for Cancer Research (Women in Cancer Research) 1999-present American Society of Preventive Oncology 1997-present American Association for Cancer Research (Molecular Epidemiology Group) 1994-present American Association for the Advancement of Science 1989-present American Society for Cell Biology Council on Undergraduate Research New York Academy of Sciences Electron Microscopy Society of the Ohio River Valley Electron Microscopy Society of America XI. SPEAKING ENGAGEMENTS Local Kentucky Lung Cancer Research Program, Governance Board, Louiville, KY, August 17, University of Kentucky Lung Cancer Screening Program: Building Institutional Infrastructure and Partnerships to Build a Better Mouse Trap for Lung Cancer Screening. University of Kentucky, Community-Based Faculty & Kentucky Ambulatory Network Conference, Preparing Practitioners for the 21 st Century: Community-campus Engagement, Lexington, KY, March 3, Workshop entitled, Collaborating to page 6

241 Andre T. Baron Date Revised: 4/1/2008 atb Increase Translational Research, Seminar entitled, University of Kentucky Lung Cancer Screening Program: The Marty Driesler Lung Cancer Project. University of Kentucky, College of Medicine, Department of Internal Medicine, Division of Hematology, Oncology, Blood and Marrow Transplantation Grand Rounds Lexington, Kentucky, November 10, Developing Soluble Epidermal Growth Factor Receptor for Lung Cancer Screening. Our Lady of Bellefonte Hospital, Northeast Kentucky Area Health Education Center, Continuing Medical Education Program, Ashland, Kentucky, October 26, 2006, Pulmonary Update: Developing Soluble Epidermal Growth Factor Receptor (segfr) for Lung Cancer Screening. University of Kentucky, Department of Surgery, Division of Urology, Lexington, Kentucky, February 20, Resident s Teaching Conference Grand Rounds, Basic Epidemiological Study Design and Data Analyses. University of Kentucky, Markey Cancer Center, Cancer Prevention and Control Program, Lexington, Kentucky, October, Biomarker Development: NIH/INBRE/KBRIN Bioinformatics Support of Markey Cancer Center Lung Cancer Screening Studies. University of Kentucky, Markey Cancer Center, Cancer Prevention and Control Program, Lexington, Kentucky, September, Biomarker Development; Lung Cancer Screening. University of Kentucky, Markey Cancer Center, Executive Committee, Lexington, Kentucky, January, Biomarkers and Bioinformatics: Developing a Screening Biomarker. University of Kentucky, Department of Internal Medicine, Division of Hematology, Oncology, Blood and Marrow Transplantation, Fellow s Lecture Series, Lexington, Kentucky, October 22, Molecular epidemiology: cancer prevention and treatment. University of Kentucky, Markey Cancer Center Weekly Conference, Lexington, Kentucky, June, Soluble EGF/ErbB1 receptors and CA-125 as biomarkers of epithelial ovarian cancer. University of Kentucky, Markey Cancer Center Symposium, The Relationship of Tobacco and HPV with Lung, Head & Neck, and Cervical Cancer, Lexington, Kentucky, May, Cancer biomarkers and their relationship to bioinformatics. University of Kentucky, Markey Cancer Center, Department of Obstetrics and Gynecology, Lexington, Kentucky, December, Soluble EGF/ErbB1 receptors and CA-125 as biomarkers of epithelial ovarian cancer. University of Kentucky, Markey Cancer Center, Kentucky School of Public Health, Lexington, Kentucky, March, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. National Marsha Rivkin Center of Ovarian Cancer Research, 5 th Biennial Ovarian Cancer Research Symposium: Emerging Controversies in Ovarian Cancer Research & Treatment, Seattle, Washington, September, Soluble epidermal growth factor receptor (segfr) and CA125: Serial versus parallel biomarker testing for ovarian cancer. Mayo Clinic Foundation, Neurooncology Research Program, Rochester, Minnesota, January, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. Louisiana State University Health Science Center, Feist-Weiller Cancer Center, Department of Medicine, Shreveport, Louisiana, September Soluble EGF/ErbB1 receptors as biomarkers of human cancer. Yale University, Yale Cancer Center, Department of Obstetrics and Gynecology, New Haven, Connecticut, July Soluble EGF/ErbB1 receptors as biomarkers of human cancer. Northwestern University, Feinberg School of Medicine, R.H. Lurie Comprehensive Cancer Center, Department of Preventive Medicine, Chicago, Illinois, July Soluble EGF/ErbB1 receptors as biomarkers of human cancer. Mayo Clinic Foundation, Breast Cancer Research Program, Rochester, Minnesota, April, Serum serbb1/segfr concentrations in women with metastatic breast cancer treated with letrozole. page 7

242 Andre T. Baron Date Revised: 4/1/2008 atb Georgetown University, Lombardi Cancer Center, Department of Oncology, Washington, D.C., January, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. University of Pennsylvania, Department of Biostatistics and Epidemiology, Philadelphia, Pennsylvania, December, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. University of Pittsburgh Cancer Institute, Magee-Women s Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh, Pennsylvania, December, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. University of Iowa, Holden Comprehensive Cancer Center, Department of Epidemiology, Iowa City, Iowa, August, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. Roswell Park Cancer Institute, Cancer Prevention Program, Population Sciences Department, Buffalo, New York, August, Soluble EGF/ErbB1 receptors as biomarkers of human cancer. University of Pittsburgh Cancer Institute, Department of Epidemiology, Pittsburgh, Pennsylvania, May, Soluble ErbB1/EGF receptors in women with epithelial ovarian cancer. Mayo Clinic Foundation, Breast Cancer Research Program, Rochester, Minnesota, October, Soluble ErbB in breast and ovarian cancer. Mayo Clinic Foundation, Tumor Biology Interest Group, Rochester, Minnesota, June, Serum serbb1 and EGF levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. Mayo Clinic Foundation, Clinical Chemistry Conference, Rochester, Minnesota, January, Serum serbb1 and EGF levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. Mayo Clinic Foundation, Biochemistry and Molecular Biology Departmental Retreat, Rochester, Minnesota, October, Secreted ErbB1 (serbb1) receptor analogs in the sera of patients with stage III/IV epithelial ovarian cancer. University of Iowa, Department of Anatomy, Iowa City, Iowa, July, A novel calciummodulated component of the centrosome: The centrin-containing pericentriolar lattice. Purdue University, Department of Anatomy, Purdue, Indiana, May, A novel calciummodulated component of the centrosome: The centrin-containing pericentriolar lattice. Pfizer Inc., Drug Metabolism Department, Groton, Connecticut, April, A novel calciummodulated component of the centrosome: The centrin-containing pericentriolar lattice. Mayo Clinic Foundation, Cell Biology Interest Group, Rochester, Minnesota, December, The role of centrin in spindle pole dynamics. Mayo Clinic Foundation, Molecular and Cell Biology Workshop, Rochester, Minnesota, April, Calcium-modulated behavior of the pericentriolar lattice. Case Western Reserve University, School of Medicine, Thirteenth Annual Graduate Research Symposium, Cleveland, Ohio, March, Calcium and temperature-modulated behavior of the pericentriolar lattice of PtK2 cells: a centrin-related matrix of the mammalian centrosome. Case Western Reserve University, School of Medicine, Eleventh Annual Graduate Research Symposium, Cleveland, Ohio, April, Identification and localization of a novel cytoskeletal centrosome associated protein, "centrin", in PtK2 cells. The American Society of Histochemistry, Fifth Janssen Symposium, Advances in Immunogold Staining, New Orleans, Louisiana, April, Immunolocalization of a ubiquitous eukaryotic centrosome associated protein using immunogold. International Cambridge Healthtech Institute and Ontario Genomics Institute, 2nd Annual Conference, Innovations in Clinical Trials: Implementation of Biomarkers, Toronto, Ontario, Canada, October 15-16, Profiling ErbB/EGFR Isoforms in Cancer Patients: Clinical Perspective. page 8

243 Andre T. Baron Date Revised: 4/1/2008 atb The Second International Cell Motility Symposium, Sophia Antipolis, France, July, The centrin-based pericentriolar lattice of PtK2 cells exhibits temperature- and calciummodulated behavior. Sixth International Congress on Spermatology, Siena, Italy, September, The centrinrelated pericentriolar lattice of mammalian centrosomes. XII. RESEARCH AND/OR CREATIVE PUBLICATIONS: A. Peer Reviewed Publications Martin, F.M., A.M. Harris, R.G. Rowland, W. Conner, M. Lane, E.B. Durbin, K.D. Kimbler, A.T. Baron, and N. Kyprianou. (2008) Decreased risk of bladder cancer in men treated with quinazoline-based α 1-adrenoceptor antagonist. Journal of Urology, Submitted. Baron, A.T., M.S. King (co-first author), K.D. Kimbler, E.T. Fung, X.Y. Meng, B. Saunders, P.D. DePriest, J.R. van Nagell, and F.R. Ueland. (2008) Ovarian cyst fluids: A cache of ovarian cancer biomarkers. Gynecologic Oncology, Submitted. Harris, A.M., B.W. Warner, J.M. Wilson, A. Becker, R.G. Rowland, W. Conner, M. Lane, K. Kimbler, E.B. Durbin, A.T. Baron, and N. Kyprianou. (2007) Effect of α 1-adrenoceptor antagonist exposure on prostate cancer incidence: an observational cohort study. Journal of Urology, 178(5): Disis, M.L., S.E. Rivkin, A. Baron, M. Markham, D. Connolly, F. Ueland, E. Kohn, E. Trimble, and J.S. Berek. (2006) Progress in ovarian cancer research: proceedings of the 5 th Biennial Ovarian Cancer Research Symposium. International Journal Gynecological Cancer, 16(2): Baron, A.T., and N.J. Maihle. (2005) Practice Point Commentary: Nadir CA125 concentration as a prognostic indicator in ovarian cancer. Nature Clinical Practice Oncology, 2:2-3. Lafky, J.M., A.T. Baron (co-first author), E.M. Cora, D.W. Hillman, V.J. Suman, E.A. Perez, J.N. Ingle, and N.J. Maihle. (2005) Serum soluble epidermal growth factor receptor concentrations decrease in postmenopausal metastatic breast cancer patients treated with letrozole. Cancer Research, 65: Baron, A.T., C.H. Boardman, J.M. Lafky, A. Rademaker, D. Liu, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2005) Soluble epidermal growth factor receptor (segfr/serbb1) and cancer antigen 125 (CA125) as screening and diagnostic tests of epithelial ovarian cancer. Cancer Epidemiology Biomarkers & Prevention, 14:1-13. Baron, A.T., E.M. Cora (co-first author), J.M. Lafky, C.H. Boardman, M.C. Buenafe, A. Rademaker, D. Liu, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2003) Soluble epidermal growth factor receptor (segfr/serbb1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer. Cancer Epidemiology Biomarkers & Prevention, 12: Perez, E.A., L. Geeraerts, V.J. Suman, A.A. Adjei, A.T. Baron, A.K. Hatfield, N.J. Maihle, J.C. Michalak, J.E. Krook, J.W. Kugler, J.M. Lafky, and J.N. Ingle. (2002) A randomized phase II study of sequential docetaxel and doxorubicin/cyclophosphamide in patients with metastatic breast cancer. Annals of Oncology 13: Maihle, N.J., J.M. Lafky, A.T. Baron, C.H. Boardman, T.M. Greenwood, T.A. Christensen, J.L. Reiter, E.M. Cora, H. Lee, V.J. Suman, D.A. Fishman, E.A. Perez and K.C. Podratz. page 9

244 Andre T. Baron Date Revised: 4/1/2008 atb (2002) EGF Receptor/ErbB isoforms as serum biomarkers in breast and ovarian cancer. J. Clinical Ligand Assay 25(1): Fishman, D.A., L. Cohen, K. Bozorgi, D. Singh, A. O Donnell, M. Donnelly, J. O Rourke, K. Pfeifer, T. Lu, N. Maihle, A. Baron, M.S. Stack, J. Lurain, and P.E. Schwartz. (2002) The scientific basis for the accurate detection of early-stage epithelial ovarian carcinoma, Part 2. The Female Patient 27: Fishman, D.A., L. Cohen, K. Bozorgi, D. Singh, A. O Donnell, M. Donnelly, J. O Rourke, K. Pfeifer, T. Lu, N. Maihle, A. Baron, M.S. Stack, J. Lurain, and P.E. Schwartz. (2002) The scientific basis for the accurate detection of early stage epithelial ovarian carcinoma, Part 1. The Female Patient 27: Christensen T.A., Reiter, N.J., A.T. Baron, J.L., Maihle. (2002) Generation and characterization of polyclonlal antibodies specific for human p110 segfr. Hybridoma and Hybridomics 21: Baron, A.T., J.M. Lafky (co-first author), V.J. Suman, D.W. Hillman, M.C. Buenafe, C.H. Boardman, K.C. Podratz, E.A. Perez, and N.J. Maihle. (2001) A preliminary study of serum concentrations of soluble epidermal growth factor receptor (serbb1), gonadotropins, and steroid hormones in healthy men and women. Cancer Epidemiology Biomarkers & Prevention 10: Baron, A.T., J.M. Lafky, C.H. Boardman, S. Balasubramaniam, V.J. Suman, K.C. Podratz, and N.J. Maihle. (1999) Serum serbb1 and EGF levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. Cancer Epidemiology Biomarkers & Prevention 8: Baron, A.T., J.M. Lafky, D.C. Connolly, J.J. Peoples, D.J. O Kane, V.J. Suman, C.H. Boardman, K.C. Podratz, and N.J. Maihle. (1998) A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (serbb1) in normal human sera. J. Immunological Methods 219: Baron, A.T., B.K. Huntley, J.M. Lafky, J.L. Reiter, J. Liebenow, D.J. McCormick, S.C. Ziesmer, P.C. Roche, and N.J. Maihle. (1997) Monoclonal antibodies specific for peptide epitopes of the epidermal growth factor receptor's extracellular domain. Hybridoma 16(3): Delvecchio, A.J., J.D.I. Harper, K.C. Vaughn, A.T. Baron, J.L. Salisbury, and R.L. Overall. (1997) Centrin homologues in higher plants are prominently associated with the developing cell plate. Protoplasma 196: Baron, A.T., V.J. Suman, E. Nemeth, and J.L. Salisbury. (1994) The pericentriolar lattice of PtK2 cells exhibits temperature and calcium-modulated behavior. J. Cell Sci. 107: Baron, A.T., T.M., Greenwood, C.W. Bazinet, and J.L. Salisbury. (1992) Centrin is a component of the pericentriolar lattice. Biol. Cell. 76: Hulen, D., A. T. Baron, J. Salisbury, M. Clarke. (1991) Production and specificity of monoclonal antibodies against calmodulin from Dictyostelium discoideum. Cell Motil. Cytoskeleton 18: Baron, A.T., T.M. Greenwood, and J.L. Salisbury. (1991) Localization of the centrin-related 165,000-Mr protein of PtK2 cells during the cell cycle. Cell Motil. Cytoskeleton 18:1-14. page 10

245 Andre T. Baron Date Revised: 4/1/2008 atb Baron, A.T. and J.L. Salisbury. (1988) Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtK2 cells. J. Cell Biol. 107: Salisbury, J.L., A.T. Baron, and M.A. Sanders. (1988) The centrin-based cytoskeleton of Chlamydomonas reinhardtii: distribution in interphase and mitotic cells. J. Cell Biol. 107: Salisbury, J.L., A.T. Baron, G.A. Keller, and D. Skiest. (1988) Membrane IgM: interactions with the cortical cytoskeleton in the human lymphoblastoid cell line WiL2. Cell Motil. Cytoskeleton 9: Clarke, M., and A. T. Baron. (1987) Myosin filaments in cytoskeletons of Dictyostelium amoebae. Cell Motil. Cytoskeleton 7: Salisbury, J.L., A.T. Baron, D.E. Coling, V.E. Martindale, and M.A. Sanders. (1986) Calciummodulated contractile proteins associated with the eukaryotic centrosome. Cell Motil. Cytoskeleton 6: Salisbury, J.L., A.T. Baron, B. Surek, and M. Melkonian. (1984) Striated flagellar roots: isolation and partial characterization of a calcium-modulated contractile organelle. J. Cell Biol. 99: B. Non-peer Reviewed Publications Baron, A.T., K. Dickerson, and J. Boyles. (2006) Early Detection and Biomarker Development, Biospecimens, Bioinformatics, and Lung Cancer Screening. Kentucky Lung Cancer Research Program Newsletter, pp Glaser, V., In consultation with A.T. Baron, S.A. Brassell, and L.P. Shulman (2005) Early cancer diagnosis: Present and future. Patient Care, 39: Baron, A.T. (1985) An autoradiographic and morphological study of cell cycle dynamics and pattern formation in tail regenerates of the salamander, Plethodon jordani. University Microfilms International, Ann Arbor, Michigan. Masters Thesis. pp C. Books, Book Chapters, Reviews, and Monographs Baron, A.T., J.M. Lafky, C.H. Boardman, E.M. Cora, M.C. Buenafe, M.S. King, D. Liu, A. Rademaker, D.A. Fishman, K.C. Podratz, J.L. Reiter, J. McAlpine, and N.J. Maihle (2008) Soluble epidermal growth factor receptor (segfr): a biomarker of epithelial ovarian cancer., In Requisites in Obstetrics and Gynecology: Gynecologic Oncology., M.S. Stack and D.A. Fishman, eds., Elsevier, Philadelphia, pp , In press. Lafky, J.M., J.A. Wilken, A.T. Baron, and N.J. Maihle. (2008) Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochimica et Biophysica Acta, Reviews in Cancer, pp , In Press. Lafky, J.M., A.T. Baron, and N.J. Maihle. (2006) Soluble epidermal growth factor receptor acridinium-linked immunosorbent assay. In Methods in Molecular Biology, Vol. 327: Epidermal Growth Factor: Methods and Protocols., T.B Patel and P.J. Bertics, eds., Humana Press, Inc., Totowa, pp Lafky, J.M, T.M. Greenwood, A.T. Baron, C.H. Boardman, E.M. Cora, and N.J. Maihle. (2002) Chapter 37, Soluble ErbB Receptors (segfr/serbbs): Serum biomarkers in breast and ovarian cancer. In Tumor Markers: Physiology, Pathobiology, Technology and Clinical page 11

246 Andre T. Baron Date Revised: 4/1/2008 atb Applications, E.P. Diamandis, H.A. Fritsche, H. Lilja, D.W. Chan and M.K. Schwartz, eds., AACC Press, pp Maihle, N.J., A.T. Baron, B.A. Barrette, C.H. Boardman, T.A. Christensen, E.M. Cora, J.M. Faupel-Badger, T.M. Greenwood, S.C. Juneja, J.M. Lafky, H. Lee, J.L. Reiter, and K.C. Podratz. (2002) Chapter 11, EGF/ErbB family receptors in ovarian cancer. In Ovarian Cancer., M.S. Stack and D.A. Fishman, eds., Kluwer Academic Publ., Boston, pp Baron, A.T., R. Errabolu, J. Dinusson, and J.L. Salisbury. (1995) Centrin-based contractile fibers: chromatographic purification of centrin. In Methods in Cell Biology, Cilia and Eukaryotic Flagella. Vol. 47, W. Dentler and G. Witman, eds., Academic Press, Inc., San Diego, pp Baron, A.T. and J.L. Salisbury. (1992) Role of centrin in spindle pole dynamics. In The Centrosome. V.I. Kalnins, editor. Academic Press, Inc., San Diego, pp Baron, A.T. and J. L. Salisbury. (1991) The centrin-related pericentriolar lattice of metazoan centrosomes. In Comparative Spermatology - 20 Years After, Serono Symposia Publications, Vol. 75, B. Baccetti, editor. Raven Press, New York, pp Bazinet, C.W., A.T. Baron, and J.L. Salisbury. (1990) Centrin: a calcium-binding protein associated with centrosomes. In Stimulus Response Coupling: The Role of Intracellular Calcium-binding Proteins. V.L. Smith and J.R. Dedman, editors. CRC Press, Inc., Boca Raton, pp D. Letters, Book Reviews E. Abstracts Baron, A.T., J.M. Lafky, K.D. Kimbler, P. Yang, and N.J. Maihle (2008) Serum concentrations of segfr as a biomarker for lung cancer. 5 th Annual Kentucky Lung Cancer Research Program Scientists Seminar, Frankfort, Kentucky. Baron, A.T., B.A. Saunders, H.S. Skaggs, R.A. Ware, M.S. King, K.D. Kimbler, B. Lynn, J. Goodman, E.T. Fung, X.Y. Meng, V. Podust, P.D. DePriest, J.R. van Nagell Jr., and F.R. Ueland (2007) Calgranulin A and B are cyst fluid biomarkers of ovarian cancer. Society of Gynecologic Oncologists, 39th Annual Meeting on Women s Cancer, Tampa, Florida. Kimbler, K.D., J.M. Lafky, K.C. Podratz, D.A. Fishman, A. Branscum, M.C. Buenafe, J.R. van Nagell, F.R. Ueland, N. J. Maihle, and A.T. Baron. (2007) Soluble epidermal growth factor receptor (segfr/serbb1) and gonadotrophic hormones as a test for epithelial ovarian cancer. University of Kentucky, Markey Cancer Center Research Day, Lexington, Kentucky. King, M.S., K.D. Kimbler, E.T. Fung, X.Y. Meng, B.A. Saunders, P.D. DePriest, J.R. van Nagell, F.R. Ueland, and A.T. Baron. (2007) Ovarian cyst fluids: A cache of ovarian cancer biomarkers. University of Kentucky, Markey Cancer Center Research Day, Lexington, Kentucky. Harris, A.M., R. Rowland, W. Conner, K. Kimbler, E. Durbin, A.T. Baron, and N. Kyprianou. (2007) Decreased risk for bladder cancer in men treated with quinazoline-based α1- adrenoceptor antagonists. The 2007 American Urological Association Meeting, Atlanta, Georgia. page 12

247 Andre T. Baron Date Revised: 4/1/2008 atb Cheuvront, L.J., M. King, K. Kimbler, B. Saunders, E. Fung, X. Meng, V. Podust, P. DePriest, J. Van Nagell, F. Ueland, and A.T. Baron. (2006) Evaluation of ovarian cyst fluids for diagnostic protein biomarkers. Kentucky Academy of Science, 92nd Annual Meeting, Morehead, Kentucky. Baron, A.T., K.D. Kimbler, J.M. Lafky, P. Ying, and N.J. Maihle. (2006) Soluble epidermal growth factor receptor (segfr) as a screening biomarker of lung cancer. 4 th Annual Kentucky Lung Cancer Research Program Scientists Seminar, Frankfort, Kentucky. Wilken, J.A., A.T. Baron, J.N. McAlpine, M. Kim, K. Kimbler, T.A. Christensen, W. Zheng, M. Martel, F.A. Tavassoli, and N.J. Maihle. (2006) Prognostic significance of EGFR isoforms in epithelial ovarian cancer. Marsha Rivkin Center of Ovarian Cancer Research, 6th Biennial Ovarian Cancer Research Symposium: From Prevention to Cure, Swedish Medical Center, Seattle, Washington. Baron, A.T., J.N. McAlpine, J. Wilken, M. Kim, K. Kimbler, T. Christensen, W. Zheng, M. Martel, F.A. Tavassoli, and N.J. Maihle. (2006) Profiling EGFR isoforms in ovarian cancer demonstrates that EGFR and segfr have prognostic significance: Implications for EGFR isoforms as cancer biomarkers. American Association of Cancer Research, The First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development: Maximizing Opportunities for Individualized Treatment. Chicago, Illinois. Wilken, J.A., A.T. Baron, J.N. McAlpine, M.O. Kim, K. Kimbler, T.A. Christensen, W. Zheng, M. Martel, F.A. Tavassoli, and N.J. Maihle. (2006) Prognostic significance of EGFR isoform expression in epithelial ovarian cancer. American Association of Cancer Research, Pathobiology of Cancer, The Edward A. Smuckler Memorial Workshop, Snowmass Village, Colorado. Harris, A., J.M. Wilson, A.B. Becker, B. Warner, R.G. Rowland, E. Durbin, M.O. Kim, A.T. Baron, and N. Kyprianou. (2006) Effect of quinazoline-based α1-adrenoceptor antagonists on prostate cancer incidence: A retrospective analysis. The 2006 American Urological Association Meeting, Atlanta, Georgia. Ueland, F.R, A.T. Baron, M. King, E.T. Fung, X.Y. Meng, V. Podust, P.D. Depriest, and J.R. van Nagell Jr. (2006) Evaluation of ovarian cyst fluids for diagnostic protein biomarkers using SELDI-TOF mass spectometry. 37 th Annual Meeting of The Society of Gynecologic Oncologists, Palm Springs, California. McAlpine, J.N, W, Zheng, T.A. Christensen, B.J. Shelton, A.T. Baron, M. Martel, F.A. Tavassoli, J.L. Reiter, and N.J. Maihle. (2005) p110 soluble isoform and p170 full-length human EGF receptor expression have prognostic significance in epithelial ovarian cancer. 36th Annual Meeting of The Society of Gynecologic Oncologists, Miami, Florida. Baron, A.T., C.H. Boardman, J.M. Lafky, A. Rademaker, D. Liu, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2004) Soluble epidermal growth factor receptor (segfr) and CA125: Serial versus parallel biomarker testing for vvarian cancer. Marsha Rivkin Center of Ovarian Cancer Research, 5 th Biennial Ovarian Cancer Research Symposium: Emerging Controversies in Ovarian Cancer Research & Treatment, Swedish Medical Center, Seattle, Washington. Mannino, D.M., F. Holguin, A.T. Baron, D.E. Doherty, and A.S. Buist. (2004) GOLD classification of COPD and incident lung cancer: Findings from a cohort study. European Respiratory Society. page 13

248 Andre T. Baron Date Revised: 4/1/2008 atb Baron, A.T., C.H. Boardman, J.M. Lafky, A. Rademaker, D. Liu, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2004) Soluble epidermal growth factor receptor (segfr/serbb1) and cancer antigen 125 (CA125) as screening and diagnostic tests of epithelial ovarian cancer. Proceedings of the American Association for Cancer Research, 45S: Fishman, D.A., N.J. Maihle, A.T. Baron, E. Petricoin, L. Liotta, L. Graves, J. So, and M.S. Stack. (2002) National Ovarian Cancer Early Detection Program, Society of Gynecologic Investigation. Cruz, M.O., A.T. Baron, J.M. Lafky, N.J. Maihle, and E.M. Cora. (2002) Decrease of a soluble isoform of the epidermal growth factor receptor (p110 segfr/serbb1) in serum of ovarian cancer patients. Marsha Rivkin Center of Ovarian Cancer Research, 4th Biennial Ovarian Cancer Research Symposium, Swedish Medical Center, Seattle, Washington. Baron, A.T., E.M. Cora, J.M. Lafky, C.H. Boardman, M.C. Buenafe, V.J. Suman, A. Rademaker, D. Liu, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2002) Serum Epidermal Growth Factor Receptor (segfr/serbb1) as a potential risk factor, screening, and diagnostic biomarker of epithelial ovarian cancer. 2 nd International National Cancer Institute- European Organization for Research and Treatment of Cancer Meeting on Cancer Diagnostics: From Discovery to Clinical Practice. Int. J. Biol. Markers, 17:S Lafky, J.M., A.T. Baron, T.M. Greenwood, D.L. Wahner-Roedler, R.E. Johnson, M.C. Buenafe, S.J. Trippel, D.J. Rhodes, E.A. Perez, B.A. Mincey, and N.J. Maihle. (2002) Associations between gonadotropins or steroid hormones and soluble EGFR/ErbB1 (serbb1), but not serb2, may predict breast disease. Proceedings of the American Association for Cancer Research, 43:236. Maihle, N.J., A.T. Baron, C.H. Boardman, J.M. Lafky, T.M. Greenwood, T.A. Christensen, J.L. Reiter, E.M. Cora, H. Lee, V.J. Suman, D.A. Fishman, E.A. Perez, and K.C. Podratz. (2001) EGF Receptor/ErbB isoforms as serum biomarkers: Results in breast and ovarian cancer. Tumor Markers: A New Era, Santa Barbara, California. Lafky, J.M., A.T. Baron, V.J. Suman, D.W. Hillman, M.C. Buenafe, C.H. Boardman, K.C. Podratz, E.A. Perez, and N.J. Maihle. (2001) Soluble epidermal growth factor receptor (serbb1), gonadotropin, and steroid hormone concentrations in healthy men and women: Reference values of the p110 serbb1 serum biomarker. Congress of Epidemiology, Toronto, Canada, American Journal of Epidemiology, 153(11):S252. Maihle, N.J., A.T. Baron, C.H. Boardman, J.M. Lafky, J.L. Reiter, E.M. Cora, D.S. Metzinger, V.J. Suman, D.A. Fishman, and K.C. Podratz (2000) serbb1/egfr p110 is a serum biomarker in women with epithelial ovarian cancer. Marsha Rivkin Center of Ovarian Cancer Research, 3rd Biennial Ovarian Cancer Research Symposium, Swedish Medical Center, Seattle, Washington. Maihle, N.J., B.A. Barrette, K.C. Podratz, R.V. Lloyd, T.A. Christensen, J.L. Reiter, P. Green, A.T. Baron, T.R. Magnuson, S.C. Juneja, and J.L. Salisbury (2000) Cloning and localization of two novel isoforms of the EGF-receptor in human placental tissues. Gordon Research Conference, Reproductive Biology Tract, Connecticut College, New London, Connecticut. Reiter, J.L., E.M. Cora, A.T. Baron, S.C. Juneja, P.J. Green, T.A. Christensen, J.M. Lafky, T.R. Magnuson, and N.J. Maihle (2000) An alternatively spliced human EGFR transcript encodes a 110-kDa cell surface localized receptor isoform which is also present in serum. FASEB Summer Research Conference, Lipid Modifications of Proteins, Copper Mountain, Colorado; and American Society of Cell Biology, San Francisco, California, Molecular Biology of the Cell, 11:29a. page 14

249 Andre T. Baron Date Revised: 4/1/2008 atb Metzinger, D.S., A.T. Baron, E.M. Cora, J.M. Lafky, V.J. Suman, K.C. Podratz, and N.J. Maihle. (2000) Development of an ALISA assay for serum p60 serbb1: a new biomarker of epithelial ovarian cancer. Proceedings of the American Association for Cancer Research, 41:565. Boardman C.H., A.T. Baron, J.M. Lafky, D. Metzinger, V.J. Suman, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (2000) Soluble ErbB1/EGFR as tumor biomarkers in women with epithelial ovarian cancer. Proceedings of the American Association for Cancer Research, 41:730. Reiter, J.L., G. Eley, E. Cora, A.T. Baron, C.D. James, and N.J. Maihle. (2000) Complete human EGFR gene structure and a novel 3 kb alternative transcript encoding a truncated 110-kDa form of the receptor. Proceedings of the American Association for Cancer Research, 41:787. Cora, E.M., A.T. Baron, J.M. Lafky, P.A. Johnson, J.N., Ingle, V.J. Suman, D.W. Hillman, and N.J. Maihle. (2000) Serum serbb1 levels in women with metastatic breast carcinoma treated with letrozole. Proceedings of the American Association for Cancer Research, 41:640. Boardman C.H., A.T. Baron, J.M. Lafky, D. Metzinger, V.J. Suman, D.A. Fishman, K.C. Podratz, and N.J. Maihle. (1999) Serum serbb1 may be a useful diagnostic biomarker of epithelial ovarian cancer. 30th Annual Meeting of The Society of Gynecologic Oncologists; and American Radium Society, London, England. Metzinger, D.S., A.T. Baron, E.M. Cora, J.M. Lafky, V.J. Suman, K.C. Podratz, and N.J. Maihle. (1999) The role of p60 serbb1 as a clinically useful biomarker of epithelial ovarian cancer. Twelfth Annual OB/GYN Residents Day Research Symposium, Mayo Clinic, Rochester, Minnesota; and 30th Annual Meeting of The Society of Gynecologic Oncologists. Barrette, B., J.L. Reiter, A.T. Baron, K.C. Podratz, and N.J. Maihle. (1999) Soluble ErbB1 and ovarian cancer: a new marker of malignant disease. 11 th International Meeting of Gynaecological Oncology, Budapest, Hungary. Boardman C.H., A.T. Baron, J.M. Lafky, D. Metzinger, V.J. Suman, K.C. Podratz, and N.J. Maihle. (1999) Serum serbb1 may be a useful diagnostic biomarker of early and late stage epithelial ovarian cancer. 28th Annual Meeting of The Western Association of Gynecologic Oncologists, Victoria, British Columbia, pp.28; Twelfth Annual OB/GYN Residents Day Research Symposium, Mayo Clinic, Rochester, Minnesota; and Balfour Surgical Research Symposium, Mayo Clinic, Rochester, Minnesota. Baron A.T., J.M. Lafky, C.H. Boardman, S. Balasubramaniam, V.J. Suman, K.C. Podratz, and N.J. Maihle. (1999) Serum EGF and soluble ErbB1 levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer. Proceedings of the American Association for Cancer Research, 40:43. Boardman C.H., A.T. Baron, J.M. Lafky, S. Balasubramaniam, V.J. Suman, K.C. Podratz, and N.J. Maihle. (1998) Serum serbb1 and EGF levels as tumor biomarkers in women with stage III or IV epithelial ovarian cancer (EOC). 27th Annual Meeting of The Western Association of Gynecologic Oncologists, Silverado Napa, California, pp. 30. Baron, A., J. Lafky, B. J. Reiter, C. Boardman, V. Suman, K. Podratz, and N.J. Maihle. (1997) Serum serbb1 (Epidermal Growth Factor Receptor) analogs in patients with stage III/IV page 15

250 Andre T. Baron Date Revised: 4/1/2008 atb epithelial ovarian cancer change following cytoreductive surgery. Growth Factor and Signal Transduction Conferences, Iowa State University, Ames, Iowa, Abstract #18. Baron, A., J. Lafky, B. Huntley, J. Heddens, R. Ashley, D. Teo, J. Reiter, S. Balasubramanian, K. Podratz, and N.J. Maihle. (1997) Soluble ErbB1 (Epidermal Growth Factor Receptor) in the sera of patients with stage III/IV epithelial ovarian cancer. Mayo Laboratory Medicine/Pathology and Cancer Center Research Symposium, Rochester, Minnesota, Abstract #75. Baron, A., J. Lafky, B. Huntley, J. Heddens, R. Ashley, D. Teo, J. Reiter, S. Balasubramanian, K. Podratz, and N.J. Maihle. (1997) Secreted ErbB1 (Epidermal Growth Factor Receptor) in the sera of patients with stage III/IV epithelial ovarian cancer. 28th Annual Meeting of The Society of Gynecologic Oncologists, South Mountain, Phoenix, Arizona. Abstract #77. Baron, A., B. Huntley, J. Lafky, J. Reiter, J. Heddens, S. Balasubramanian, R. Ashley, D. Teo, and N.J. Maihle. (1996) Secreted ErbB1 receptor analogs in the sera of patients with stage III and IV ovarian cancer. Mayo Clinic, 6th Annual Biochemistry and Molecular Biology Departmental Retreat, Rochester, Minnesota. Baron, A., J. Lafky, B. Huntley, J. Heddens, R. Ashley, D. Teo, J. Reiter, S. Balasubramanian, and N.J. Maihle. (1996) Secreted ErbB1 receptor analogs in the sera of patients with stage III and IV ovarian cancer. 5th Annual University of Minnesota Symposium in Developmental Biology, Minneapolis, Minnesota, Abstract #2. Baron, A., B. Huntley, J. Lafky, J. Reiter, J. Heddens, R. Ashley, S. Balasubramanian, and N.J. Maihle. (1996) Secreted ErbB1 receptor analogs in the sera of patients with stage III and IV ovarian cancer. Mol. Biol. Cell, 7:24a. Maihle N., S. Balasubramanian, A. Baron, H. Lee, and J. Reiter. (1996) Soluble receptors encoded by members of the c-erbb family have anti-oncogenic activity and may function as tumor suppressors. Cancer Genetics and Tumor Suppressor Genes, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp Hsiao, K.-H., A.T. Baron, J.L. Salisbury, and M.A. McNiven. (1992) Purification of a centrinlike protein from bovine brain. Mol. Biol. Cell, 3:346a. Baron, A.T., T.M. Greenwood, E. Nemeth, C.W. Bazinet, and J.L. Salisbury. (1992) The centrinbased pericentriolar lattice of PtK2 cells exhibits calcium-modulated contractile behavior. Mol. Biol. Cell 3:346a. Baron, A.T., T.M. Greenwood, E. Nemeth, and J.L. Salisbury. (1992) The centrin-based pericentriolar lattice of PtK2 cells exhibits temperature- and calcium-modulated behavior. The Second International Cell Motility Symposium, Sophia Antipolis, France Sanders, M.A., A.T. Baron, and J.L. Salisbury. (1992) Flagellar excision in Chlamydomonas reinhardtii: centrin-mediated microtubule severing. The fifth International Conference on the Cell and Molecular Biology of Chlamydomonas. Grams, J.M., A.T. Baron, and J.L. Salisbury. (1992) Generation of monoclonal antibodies toward centrin. Sixth National Conference on Undergraduate Research, Minneapolis, Minnesota, Abstract #950. Sanders, M.A., A.T. Baron, and J.L. Salisbury. (1991) Flagellar excision in Chlamydomonas reinhardtii II: centrin-mediated microtubule severing. J. Cell Biol., 115: 38a. page 16

251 Andre T. Baron Date Revised: 4/1/2008 atb Greenwood, T.M., C. Bazinet, A.T. Baron, M.A. Sanders, N.J. Maihle, and J.L. Salisbury. (1990) Antibodies against a bacterially expressed trpe-centrin fusion protein recognize centrosomes from diverse organisms. J. Cell Biol., 111:182a. Baron, A.T. and D.F. Smith. (1990) Immunological identification and localization of hsp90 forms in QT6 quail fibroblasts. The American Society for Cell Biology, First Regional Meeting, Chicago, Illinois, Abstract #52. Baron, A.T., T.M. Greenwood, and J.L. Salisbury. (1989) Cell cycle dependent changes of the pericentriolar lattice of PtK2 cells. The American Society for Cell Biology, Summer Research Conference, Chromosome Structure and Segregation, Airlie, Virginia, Abstract #39a. Baron, A.T., T.M. Greenwood, E. Nemeth, and J.L. Salisbury. (1989) Aggregation of the centrin-related pericentriolar lattice of PtK2 cells is coincident with increased intracellular free calcium. J. Cell Biol., 109:76a. Baron, A.T. and J.L. Salisbury. (1989) Calcium-modulated behavior of the pericentriolar lattice of PtK2 cells: a centrin-related matrix of the mammalian centrosome. J. Cell Biol., 107:16a. Sanders, M.A, A.T. Baron, and J.L. Salisbury (1987) Immunolocalization of a ubiquitous eukaryotic centrosome associated protein using immunogold. The American Society of Histochemistry, Fifth Janssen Symposium, Advances in Immunogold Staining, New Orleans, Louisiana, Abstract #4. Baron, A.T. and J.L. Salisbury. (1987) Identification and localization of a novel cytoskeletal centrosome associated protein, "centrin", in PtK2 cells. J. Cell Biol., 105:205a. Reines, D., A.T. Baron, and M. Clarke. (1985) Myosin filaments in contractile cytoskeletons of Dictyostelium amoebae. J. Cell Biol., 101:157a. Salisbury, J.L. and A.T. Baron. (1984) Evidence for ligand-induced association of membrane IgM with the cytoskeleton of the human lymphoblastoid cell line WiL2. J. Cell Biol., 99:298a. Salisbury, J.L., M. Melkonian, B. Surek, and A.T. Baron. (1984) Striated flagellar roots: calcium modulated contractile organelles. J. Cell Biol., 97:198a. F. Other XIII. GRANT AND CONTRACT ACTIVITY: Principal Investigator, A1 Resubmission of Serum segfr, CA125, and Other Complementary Biomarkers As Diagnostic Tests for Ovarian Cancer from the National Institute of Health, $1,840,111 total costs, 25% effort, extramural, approved and pending Principal Investigator, A1 Resubmission of Serum segfr, FSH, LH, and CA125 Biomarker Screening Test for Ovarian Cancer from the National Institutes of Health, $2,159,372 total costs, 25% effort, extramural, approved and pending Co-Mentor/Sponsor to Dr. Jason Wilken, Postdoctoral Fellow, Overcoming Primary Herceptin Resistance in Breast Cancer from Komen Foundation, $180,000 total costs, 0% effort, extramural, approved and funded. page 17

252 Andre T. Baron Date Revised: 4/1/2008 atb Principal Investigator, Profiling EGFR Isoforms in Ovarian Cancer from the Ovarian Cancer Research Fund, Inc., $464,252 total costs, 20% effort, extramural, approved but not funded Mentor/Sponsor to Dr. Hollie S. Skaggs, Postdoctoral Research Scholar, Regulation of Sec61-dependent EGFR Retrotranslocation by masegfr from Ovarian Cancer Research Foundation, $74,995 total costs, 1% effort, extramural, approved but not funded Principal Investigator, Nuclear Translocation of EGFR-EGF-masEGFR via Sec 61 Translocon from Kentucky Science and Engineering Foundation, $19,965 total costs, 5% effort, extramural, approved but not funded Principal Investigator, Comprehensive Analysis of Matched Serum and tumor ErbB Biomarkers to Predict Responsiveness to Herceptin from Department of Defense, Breast Cancer Research Program, Impact Award, $2,145,204 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Profiling Novel ErbB Biomarkers to Predict Responsiveness to Herceptin from Department of Defense, Breast Cancer Research Program, Synergistic Idea Award, $258,671 total costs, 10% effort, extramural, approved but withdrawn Principal Investigator, Serum segfr, CA125, and Other Complementary Biomarkers As Diagnostic Tests for Ovarian Cancer from the National Institute of Health, $1,507,109 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Protocol Number: OVA-001-T1, OvaRi Assay Performance Testing Clinical Trial Using Serum From Women With Documented Ovarian Tumors from Vermillion, Inc., Fremont, CA, $55,009 total costs, 8% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD1, To determine the effect of serum separation time post phlebotomy onovarian PC1 biomarkers from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD2, To compare the effect of different type BD vacutainer tubes on ovarian PC1 biomarkers from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD3, To compare serum separation timepoins at 4 o C vs room temperature (RT) using the Ciphergen ovarian PC1 biomarker assay from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0% effort, extramural, approved and funded contract Principal Investigator, Profiling Novel ErbB Biomarkers to Predict Responsiveness to Herceptin from Department of Defense, Breast Cancer Research Program, Synergistic Idea Award, $269,658 total costs, 10% effort, extramural, approved but not funded Co-Investigator, Early detection of lung cancer in a high-risk population defined by pulmonary function testing, biomarker identification, and computerized tomography scanning from Kentucky Lung Cancer Research Program, $144,086 total costs, 0.5% effort, extramural, approved and funded Principal Investigator, Interrogation of Matched Cyst Fluid and Serum for Biomarkers of Early Stage Ovarian Cancer from the National Institutes of Health, $402,875 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Serum segfr, FSH, LH, and CA125 Biomarker Screening Test for Ovarian Cancer from the National Institutes of Health, $1,972,148 total costs, 25% effort, extramural, approved but not funded. page 18

253 Andre T. Baron Date Revised: 4/1/2008 atb Principal Investigator, Profiling Novel ErbB Biomarkers to Predict Responsiveness to Herceptin from the Susan G. Komen Breast Cancer Foundation, $2,992,834 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Profiling EGFR Isoforms in Ovarian Cancer from the Ovarian Cancer Research Fund, Inc., $464,252 total costs, 20% effort, extramural, approved but not funded Co-Investigator, KY-IDeA Networks of Biomedical Research Excellence from the National Funded Center for Research Resources, $668,673 5/1/2006 4/30/2007 total costs, 1% effort, extramural, approved and funded contract Principal Investigator, Serum segfr, FSH, LH and CA125 Biomarker Screening Test for Ovarian Cancer from the Department of Defense, $732,003 total costs, 25% effort, extramural, approved but not funded Principal Investigator, An evaluation of ovarian cyst fluid for protein biomarkers using SELDI-TOF mass spectrometry. from the Department of Defense, $732,338 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Ovarian Cyst Fluid Proteomics as a Diagnostic Test for Ovarian Cancer from National Cancer Institute, $3,649,629 total costs, 25% effort, extramural, approved but not funded Principal Investigator, Pilot Study of Exhaled Breath Condensate as a Cache of Lung Cancer Biomarkers from Kentucky Lung Cancer Research Program, $150,000 total costs, 10% effort, extramural, approved but not funded Principal Investigator, Pilot SELDI-TOF MS Study of Ovarian Cyst Fluids from Marsha Rivkin Center for Ovarian Cancer Research, $30,000 total costs, 5% effort, extramural, approved but not funded Co-Investigator, Ovarian Cancer Screening Trial in Women at Genetic Risk from National Cancer Institute, $361,400 total costs, 10% effort, extramural, approved but not funded Principal Investigator, Exhaled Breath Condensate and Diagnostic Biomarkers of Lung Cancer from Kentucky Science & Engineering Foundation, $100,000 total costs, 10% effort, extramural, approved but not funded Co-Principal Investigator, A Cell-Based Biosensor for Early Screening of Cancer from Kentucky Science & Engineering Foundation, $99,967 total costs, 5% effort, extramural, approved and funded Principal Investigator, Biomarker Discovery in Benign and Malignant Ovarian Cyst Fluids from Center of Biomedical Research Excellence on the Molecular Basis of Human Disease, National Cancer Institute, $100,000 total costs, 10% effort, intramural, approved but not funded Principal Investigator, segfr Development and Biomarker Discovery in Epithelial Ovarian Cancer from the Department of Defense, $878,600 total costs, 10% effort, extramural, approved but not funded Co-Investigator, Oxidant Stress & Comorbidity in COPD Exacerbations from National Heart, Lung, and Blood Institute, $1,830,750 total costs, 10% effort, extramural, approved but not funded Principal Investigator, segfr Development & Biomarker Discovery in Lung Cancer from National Cancer Institute, $3,693,474 total costs, 50% effort, extramural, approved but not funded Principal Investigator, Biomarker Discovery in Lung and Ovarian Cancer from National Cancer Institute, $3,724,352 total costs, extramural, 50% effort, approved but not funded. page 19

254 Andre T. Baron Date Revised: 4/1/2008 atb Co-Investigator, Ovarian Cancer Screening Trial in High Risk Women from National Cancer Institute, $361,670 total costs, 20% effort, extramural, approved but not funded Co-Investigator, The Marty Driesler Cancer Project: Early Detection of Lung Cancer in a High Risk Population Defined by Pulmonary Function Testing, Biomarkers, and Computed Tomography from the Centers for Diease Control, $1,000,000 total direct first year costs, 4% effort, extramural, approved and funded Co-Investigator, The Non-invasive Evaluation of Solitary Pulmonary Nodules using Contrast-Enhanced CT, PET Scan, and Serum Markers from Kentucky Lung Cancer Research Program, $300,000 total costs, 5% effort, extramural, approved and funded Principal Investigator, Evaluating Low Dose Computed Tomography and Serum Biomarkers for Lung Cancer Screening from Kentucky Lung Cancer Research Program, $600,000 total costs, 20% effort, extramural, approved and funded Co-investigator, Serum Concentrations of Soluble Epidermal Growth Factor Receptor (serbb1) as Risk Factors of Human Carcinoma from Mayo Foundation, Department of Family Medicine, $5,000 total costs, 0% effort, intramural, approved and funded Component Investigator, N9931, Phase III Trial of the Addition of Trastuzumab (Herceptin) to Paclitaxel and Carboplatin as First-Line Chemotherapy in Women with Metastatic Breast Cancer with 1+HER-2 Expression and in Women with Metastatic Breast Cancer with 2+HER-2 Expression from the North Central Cancer Treatment Group, $1,421,504 total costs, 0% effort, extramural, approved and funded Co-investigator, p60 serbb1 as a Clinically Useful Biomarker of Epithelial Ovarian Cancer from Mayo Foundation, $70,000 total costs, 0% effort, intramural, approved and funded Co-investigator, Circulating serbb1, serbb2, and CA-125 Levels as Diagnostic and Prognositic Biomarkers in Women with Epithelial Ovarian Cancer from Mayo Foundation, $70,000 total costs, 0% effort, intramural, approved and funded Principal Investigator, Circulating serbb1 Levels as Diagnostic Tumor Biomarkers from National Institutes of Health / National Cancer Institute, R21 CA82520, $225,300 total costs, 10% effort, extramural, approved and funded Principal Investigator, Serologic serbb1 in Healthy Women from National Institutes of Health / National Cancer Institute, RO3 CA82091, $150,200 total costs, 10% effort, extramural, approved and funded Principal Investigator, Circulating serbb1 and serbb2 Levels as Breast Cancer Biomarkers from Friends you can count on... Foundation, $40,000 total costs, 0% effort, extramural, approved and funded Principal Investigator, Soluble ErbB1 Molecules as Tumor Biomarkers from National Institutes of Health / National Cancer Institute, KO7 CA 76170, $402,041 total costs, 80% effort, extramural, approved and funded Co-investigator, Serologic serbb1 Levels in Ovulating and Pregnant Women from Mayo Clinic Foundation, $141,878 total costs, intramural, approved but not funded Co-investigator, Circulating serbb3 Levels as Breast Cancer Biomarkers from U.S. Army Medical Research and Materiel Command, $318,424 total costs, extramural, approved but not funded Co-investigator, serbb1: A Novel Biomarker in Ovarian Cancer from Mary Kay Ash Charitable Foundation, $100,000 total costs, extramural, approved but not funded page 20

255 Andre T. Baron Date Revised: 4/1/2008 atb Co-investigator, Amphiregulin and Soluble ErbB1 as Tumor Biomarkers in Prostate Cancer from American Cancer Society, Inc., $286,279 total costs, extramural, approved but not funded Co-Investigator, Soluble ErbB1 Molecules as Tumor Biomarkers in Ovarian Cancer from Gynecologic Oncology Group/National Cancer Institute, $149,326 total costs, extramural, approved but not funded Principal Investigator, Soluble ErbB1 Molecules as General Cancer Biomarkers from Cancer Research Foundation of America, $35,000 total costs, extramural, approved but not funded Principal Investigator, Soluble ErbB1 Molecules as Tumor Biomarkers from National Institutes of Health/National Cancer Institute, $377,775 total costs, extramural, approved but not funded. XIX. RESEARCH PROJECTS: Co-Investigator, Early detection of lung cancer in a high-risk population defined by pulmonary function testing, biomarker identification, and computerized tomography scanning from Kentucky Lung Cancer Research Program, $150,000 total costs, 0.5% effort, extramural, approved and funded Principal Investigator, Protocol Number:OVA-001-T1, OvaRI Assay Performance Testing Clinical Trial Using Serum From Women With Documented Ovarian Tumors from Vermillion, Inc., Fremont, CA, $55,009 total costs, 8% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD1, To determine the effect of serum separation time post phlebotomy onovarian PC1 biomarkers from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0.5% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD2, To compare the effect of different type BD vacutainer tubes on ovarian PC1 biomarkers from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0.5% effort, extramural, approved and funded contract Co-Investigator, Protocol Number: OVA-001-CLD3, To compare serum separation timepoins at 4 o C vs room temperature (RT) using the Ciphergen ovarian PC1 biomarker assay from Vermillion, Inc., Fremont, CA, $ per patient recruited, 0.5% effort, extramural, approved and funded contract Co-Principal Investigator, Bronchoalveolar Lavage (BAL) Fluid Biomarker Research Study from University of Kentucky, 1% effort, intramural, approved and unfunded Co-Principal Investigator, A Cell-Based Biosensor for Early Screening of Cancer from Kentucky Science & Engineering Foundation, $99,967 total costs, 5% effort, extramural, approved and funded Co-Investigator, KY-IDeA Networks of Biomedical Research Excellence from the National Funded Center for Research Resources, $610,199 5/1/2007 4/30/2008 total costs, 1% effort, extramural, approved and funded subcontract Co-Principal Investigator, The Marty Driesler Cancer Project: Early Detection of Lung Cancer in a High Risk Population Defined by Pulmonary Function Testing, Biomarkers, and Computed Tomogaphy from the Centers for Diease Control, $1,000,000 total direct first year costs, 4% effort, extramural, approved and funded Principal Investigator, Evaluating Low Dose Computed Tomography and Serum Biomarkers for Lung Cancer Screening from Kentucky Lung page 21

256 Andre T. Baron Date Revised: 4/1/2008 atb Cancer Research Program, $600,000 total costs, 10% effort, extramural, approved and funded Co-Investigator, The Non-invasive Evaluation of Solitary Pulmonary Nodules using Contrast-Enhanced CT, PET Scan, and Serum Markers from Kentucky Lung Cancer Research Program, $300,000 total costs, 5% effort, extramural, approved and funded Co-investigator, Serum Concentrations of Soluble Epidermal Growth Factor Receptor (serbb1) as Risk Factors of Human Carcinoma from Mayo Foundation, Department of Family Medicine, $5,000 total costs, 0% effort, intramural, approved and funded Component Investigator, N9931, Phase III Trial of the Addition of Trastuzumab (Herceptin) to Paclitaxel and Carboplatin as First-Line Chemotherapy in Women with Metastatic Breast Cancer with 1+HER-2 Expression and in Women with Metastatic Breast Cancer with 2+HER-2 Expression from the North Central Cancer Treatment Group, $1,421,504 total costs, 0% effort, extramural, approved and funded Co-investigator, p60 serbb1 as a Clinically Useful Biomarker of Epithelial Ovarian Cancer from Mayo Foundation, $70,000 total costs, 0% effort, intramural, approved and funded Co-investigator, Circulating serbb1, serbb2, and CA-125 Levels as Diagnostic and Prognositic Biomarkers in Women with Epithelial Ovarian Cancer from Mayo Foundation, $70,000 total costs, 0% effort, intramural, approved and funded Principal Investigator, Circulating serbb1 Levels as Diagnostic Tumor Biomarkers from National Institutes of Health / National Cancer Institute, R21 CA82520, $225,300 total costs, 10% effort, extramural, approved and funded Principal Investigator, Serologic serbb1 in Healthy Women from National Institutes of Health / National Cancer Institute, RO3 CA82091, $150,200 total costs, 10% effort, extramural, approved and funded Principal Investigator, Circulating serbb1 and serbb2 Levels as Breast Cancer Biomarkers from Friends you can count on... Foundation, $40,000 total costs, 0% effort, extramural, approved and funded Principal Investigator, Soluble ErbB1 Molecules as Tumor Biomarkers from National Institutes of Health / National Cancer Institute, KO7 CA 76170, $402,041 total costs, 80% effort, extramural, approved and funded. XX. OTHER CREATIVE ACTIVITY: Patents 6/23/06 (filing date) European Patent application Serial No entitled, Biomarkers for Ovarian Cancer 6/24/05 (filing date) U.S. Patent application Serial No. 60/693,755 entitled, Biomarkers for Ovarian Cancer 3/8/05 (filing date) U.S. Patent application CIP Serial No. 60/659,508 entitled, Soluble Epidermal Growth Factors Receptor Uses for Lung Cancer 3/31/01 (filing date) U.S. Patent application CIP Serial No. 60/280,630 entitled, Soluble Epidermal Growth Factor Receptor-like and Cancer Antigen Proteins and Their Uses in Detecting and Monitoring Cancer page 22

257 Andre T. Baron Date Revised: 4/1/2008 atb 9/29/00 (filing date) U.S. Patent application Serial No. 09/676,380 entitled, Soluble Epidermal Growth Factor Receptor-like Proteins and Their Uses in Cancer Detection Methods 9/30/99 (filing date) U.S. Patent application Serial No. 60/157,144 entitled, Soluble Epidermal Growth Factor Receptor-like Proteins and Their Uses page 23

258 CURRICULUM VITAE Ann L. Coker, PhD October 2007 CURRENT POSITION Professor and Verizon Wireless Endowed Chair in the Center for Research on Violence Against Women The University of Kentucky School of Medicine, Department of Obstetrics and Gynecology 800 Rose St, UK Chandler Hospital, C 371 Phone: (859) Fax: (859) [email protected] EDUCATION College / University Major Dates Degree Auburn University Chemistry / Sociology 1980 BS University of Texas Health Science Center Population Studies 1984 MPH University of North Carolina Epidemiology 1989 PhD PROFESSIONAL EXPERIENCE Dates Firm / Institution Rank / Position 2007-Present University of Kentucky, Professor and Endowed Chair School of Medicine University of Texas, Professor School of Public Health Epidemiology Discipline University of Texas, Associate Professor School of Public Health Epidemiology Discipline University of South Carolina Associate Professor, Dept of Epidemiology and Biostatistics University of South Carolina Assistant Professor, Dept of Epidemiology and Biostatistics HONORS AND AWARDS 2005 McGovern Teaching Award, School of Public Health, University of Texas Health Science Center at Houston 1994 James A. Keith Excellence in Teaching Award, School of Public Health, University of South Carolina 1993 American Association for Cancer Research, 1991 Delta Omega, University of South Carolina, President Sigma Xi, University of South Carolina 1988 Invited participant in the Society for Epidemiologic Research Student Workshop National Cancer Institute Traineeship Award 1985 National Institute for Child Health and Development Traineeship Award 1

259 RESEARCH SUPPORT CURRENT Principal Investigator Principal Investigator Principal Investigator Principal Investigator Using batterer psychologic profiles for prevention of partner violence (R49 grant), Centers for Disease Control and Prevention, 9/2005 8/2008; $300,000 total year 1; $899,999 total (25% time) Major goals: To estimate prevalence of and risk factors for physical partner violence perpetration by batterer typology (a) generally violent / antisocial personality (GVA), (b) borderline personality disorder (BD), and (c) relationship only (RO) in a multi-ethnic community-based sample of approximately 1200 community college students and their partners (estimate 2000) by ethnicity and gender. Air Toxics and Cancer Incidence in Texas (Environmental Public Health Services) City of Houston, Department of Health and Human Services, Subcontract from Centers for Disease Control grant, 8/2005-7/2006; $27,623 (5% time) Major Goals: To link Texas Commission on Environmental Quality data with Texas Cancer Incidence data to determine whether specific cancer rates are higher in areas with higher butadiene and benzene levels in the air. Understanding disparities in cervical cancer survival (R21 grant), National Cancer Institute, 4/2005 3/2007; $229,289 total year 1; $392,769 total (20% time) Major goals: To explore disparities in cervical cancer stage at diagnosis, treatment and survival in Texas, a large state with great ethnic, income, and rural / urban diversity. Demonstration Projects for the Early Intervention and Prevention of Sexual Violence and Intimate Partner Violence Among Racial and Ethnic Minority Populations (US4CCU cooperative agreement), Centers for Disease Control and Prevention, 9/2000-8/2006 (no cost extension); $399,720 per year; $1,998,605 total (25% time) Major goals: To screen women attending primary care clinics for partner sexual and physical violence; test two clinic-based randomized interventions to reduce the impact of violence for women and children. 2

260 RESEARCH SUPPORT CURRENT (continued) Investigator Investigator Mentor Creation of the Hispanic Health Research Center in the Lower Rio Grande Valley. National Institutes of Health (MD P20; Joseph McCormick, PI), 2/ /2008, $1,265,000 per year; $4,948,500 total (10% time) Major goals: To integrate research, staff, and resources of the Texas Lower Rio Grande Valley Project EXPORT into the local communities of the area. This will be accomplished by working closely with the other cores of Project EXPORT to coordinate outreach activities so that this project can serve as a catalyst for change. A study to evaluate the health effects of air pollution in Bexar County with a focus on the types of emissions associated with coal-fired power plants. City of San Antonio (J Perkins, PI), 06/ /2007, $227,200 Department of Defense Prostate Cancer Research Program (PCRP) of the Office of the Congressionally Directed Medical Research Programs (CDMRP). Title: GSBS and TSU Undergraduate Collaborative Summer Training Program. PI McDonnell (MD Anderson) Coker (Faculty mentor) COMPLETED Principal Investigator Principal Investigator SIP-11: Network for Understanding Lack of Pap Follow-up, Centers for Disease Control and Prevention, 9/ /2004; $325,000 year 1; $650,000 total; (25% time) Major goals: To identify individual and health care system barriers to obtaining follow-up care for an abnormal Pap smear through qualitative and quantitative studies. Psychological Abuse Study, supplemental contract from the Centers for Disease Control and Prevention, National Injury Center, 9/2002/ - 11/2003, $90,000; (15% time) Major goals: To establish cut points for psychological abuse using the 58-item psychological maltreatment of women scale among women experiencing physical, sexual, or psychological abuse and those who are experiencing no partner violence. RESEARCH SUPPORT 3

261 COMPLETED (continued) Principal Investigator Principal Investigator Principal Investigator Principal Investigator Principal Investigator Principal Investigator Abuse in Pregnancy. Contract with Centers for Disease Control and Prevention, Reproductive Health, 11/2001/ - 10/2002, $15,000 Major goals: To conduct an analysis, draft and submit a manuscript on abuse during pregnancy and pregnancy outcomes. Impact of HR-HPV Positivity on Women, Formative Research, Centers for Disease Control and Prevention, 10/2001 9/2002, (PA Sharpe became PI on my move to UTSPH), $199,780 Major goals: To determine the attitude toward and knowledge of HR-HPV transmission and the impact of this diagnosis on women and their partners. HPV, Adeno-associated virus and cervical neoplasia (R03). National Cancer Institute, 5/1997-5/1999, $69,000 Major goals: To conduct an analysis of existing cervical samples for adeno-associated virus to determine whether AAV interacts with HPV to reduce risk of cervical neoplasia. Effect of interview conditions on rape and domestic violence reporting, American Statistical Association, 6/1997-5/1999, $20,000 Major goals: To conduct an analysis of the National Crime Victimization Survey redesign data to determine whether gag factor for reporting sexual assaults and partner violence still have an impact on population-based rates estimation after implementing the new violence questions. Impact of Stress and Control on Women s Health (R49 grant), Centers for Disease Control and Prevention, National Injury Center, 9/1996-8/1999, $399,000; (25% time) Major goals: To conduct a cross-sectional survey of women attending primary care clinics to determine the frequency of partner violence by time and the health correlates of violence. Environmental and Occupational Risk Factors for Kidney Cancer in South Carolina, South Carolina Cancer Center, Grant in Aid, 2/1995-1/1996, $14,500 (Co-PI: Francisco Gonzalez, MD) Major goals: To explore the feasibility of conducting a population-based case-control study of environmental factors and kidney cancer. 4

262 RESEARCH SUPPORT COMPLETED (continued) Principal Investigator CIN Risk: Interaction with HPV, diet, smoking & race (R29 First Award), National Cancer Institute, 5/1994-4/2000, $513,243; (75% time) Major goals: To conduct a clinic based nested case-control study exploring the interactions between diet, smoking, race and high risk HPV types on cervical neoplasia development. Principal Investigator Principal Investigator Principal Investigator Principal Investigator Co-Principal Investigator Adjusting the National Crime Survey's estimates of rape and domestic violence for "Gag" factors in reporting, National Institute of Justice, 10/1993-9/1994, $25,000 (Co-PI: Stasny E.A. at Ohio State University) Major goals: To conduct an analysis of the National Crime Victimization Survey data to determine whether presence of a partner during the interview gags the woman s reporting sexual assaults and partner violence. Collaborative investigation of the prevalence of HPV among South Carolinians, South Carolina Cancer Center, Grant in Aid, 1/1993-1/1994, $10,800 (Co-PI: LA Pirisi, Pathology, USC) Pre-test of questionnaire and development of a food frequency questionnaire for low-income black women, Research and Productive Scholarship Award, University of South Carolina, 5/ /1991, $3,000 HPV & cervical dysplasia in a low-income minority population (IRG107P), American Cancer Society - Institutional Grant for Cancer Related Research, USC, 12/ /1991, $7,500 Multilevel analysis of socioeconomic status and prostate cancer risk, Centers for Disease Control and Prevention American Schools of Public Health, (Maureen Sanderson, PI), 10/1999-9/2002, $106,307 year 1; $299,995 total; (20% time) Major goals: To conduct population-based case-control study of stress, coping, socio-economic status and prostate cancer among older African American and Caucasian men. 5

263 RESEARCH SUPPORT COMPLETED (continued) Co-Principal Investigator Co-Principal Investigator Co-Investigator Co-Investigator Co-Investigator Co-Investigator Human exposure to corn-based fumonisin mycotoxins in coastal South Carolina, United States Department of Agriculture, 9/1994-8/1996, $140,885 (TL Leatherman, PI Anthropology, USC) Major goals: To conduct a population based study of nutrition and health related to possible fumonisin exposure in rural South Carolina. The Cervical Cancer program of the South Carolina Cancer Center, South Carolina Cancer Center Challenge Award, 8/1993-7/1995, (LA Pirisi, PI) $50,000 Using the South Carolina Central Cancer Registry to conduct a case-control study of prostate cancer, South Carolina Cancer Center, 4/1997-7/1998, (Maureen Sanderson, PI), $20,000 Ethnic variation in hysterectomy, oophorectomy, and hormone replacement therapy, Centers for Disease Control and Prevention, 10/1995-9/1997, (RE McKeown, PI), $340,000 Physical activity, estrogen metabolism, and breast cancer risk, Centers for Disease Control, project with the USC Prevention Center, 10/1993-9/1995, (CA Macera, PI for Center Grant; M Crane, Co-PI for project) $27,076 Explaining the disadvantaged's high infant mortality risk, Centers for Disease Control as a USC Prevention Center, 10/1990-9/1992, (G Coston, PI for center grant; AL Coker PI for project) UTHSC-H SPH Excellence in Research Incentive Award 2003, 2004,

264 PUBLICATIONS IN PEER-REVIEWED JOURNALS (*Indicates student or post-doctoral fellow was first author) In Press 1. Camp EA, Coker AL, Troisi R, Robboy JS, Noller KL, Palmer JR, Goodman KJ, Titus- Ernstoff LT, Hatch EE, Herbst AL, Kaufman RH, Adam E. Cervical Cancer Screening Behaviors of Women Exposed In-utero to Diethylstilbestrol. Journal of Lower Urogenital Tract. 2. Coker AL, Sanderson M, Cantu E, Huerta D, Fadden MK. Types of partner violence among Mexican-American college women. Journal of American College Health. 3. Liu L, Coker AL, Du XL, Cormier JN, Ford CE, Fang S. Long-Term Survival after Radical Prostatectomy Compared to Other Treatments in Older Men with Local or Regional Prostate Cancer. Journal of Surgical Oncology. Journal of Surgical Oncology 4. Coker, AL, Eggleston, KS, Du XL, Ramondetta L. Ethnic disparities in cervical cancer survival among Medicare eligible women in a multi-ethnic population. International Journal of Gynecological Cancer 5. Westin S, Ramondetta L, Coker AL. (others). Social Factors Affecting Treatment of Cervical Cancer: A Case Report and Review of the Literature" to the New England Journal of Medicine. In Print 6. Rohatgi N, Du XL, Coker AL, Moye L, Wang M, Fang S. Chemotherapy and survival for patients with multiple myeloma: findings from a large nationwide and populationbased cohort.am J Clin Oncol Oct;30(5): Coker AL, Whitaker DP, Fadden MK, Flerx VC, Smith PH. Intimate partner violence incidence and continuation in a primary care screening program. Am J Epidemiol. 2007;165(7): Coker AL, Eggleston KS, Meyer TE, Luchok K, Prabhu Das, I. What predicts adherence to follow-up recommendations for abnormal Pap tests? Gynecologic Oncology 105(1) 2007: Coker, AL. Does Intimate Partner Violence Affect Sexual Health? A systematic review. Trauma, Violence & Abuse.2007;8: Coker AL, Flerx VC, Smith PH, Whitaker DJ, Fadden MK, Williams, M. Partner violence assessment in rural health care clinic, Am J Public Health; 2007; 97(7): Weston RW, Marshall LL, Coker AL. Women's motives for violent and nonviolent behaviors in conflicts.j Interpers Violence. 2007; (8): Eggleston KS, Coker AL, Luchok KJ, Meyer TE. Adherence to recommendations for abnormal Pap follow-up does not differ by race. Obstetrics & Gynecology. 109(6):

265 13. Eggleston KS, Coker AL, Das IP, Cordray ST. Luchok KJ. Understanding barriers for adherence to follow-up care for abnormal pap tests. Journal of Women's Health. 16(3):311-30,

266 In Print 14. Eggleston KS, Coker AL, Williams M, Tortolero-Luna G, Martin JB, Tortolero SR. Socioeconomic Status as a Predictor of Cervical Cancer Survival in Texas, , Journal of Women s Health. Journal of Women's Health. 15(8):941-51, Rivera S, Vernon SW, Tiro JA, Coan S, del Junco D.Chan W, Coker A. Test-retest Reliability of Self-Reported Mammography Practices in Women Veterans. Preventive Medicine Apr;42(4): Meyer TE, Coker AL, Sanderson M, Symanski E. A case-control study of farming and prostate cancer in African-American and Caucasian men. Occupational & Environmental Medicine. 64(3):155-60, Sanderson M, Coker AL, Perez A, Du XL, Peltz G, Fadden MK. A multilevel analysis of socioeconomic status and prostate cancer risk. Annals of Epidemiology,2006; 16(12): Coker AL, Sanderson M, Ellison GL, Fadden, MK. Stress, coping, social support, and prostate cancer risk among older African American and Caucasian men. Ethnity and Disease 2006;16(4): Coker AL, Hanks JS, Eggleston KS, Risser J, Tee PG, Chronister KJ, Troisi CL, Arafat R, Franzini L. Social and mental health needs assessment of Katrina evacuees. Disaster Management Response. 2006;4(3): Coker AL, Du XL. Fang S, Eggleston KS. Socioeconomic Status and Cervical Cancer Survival among Older Women: Findings from the SEER Medicare Linked Data Cohorts. Gynecologic Oncolog. 2006; 102(2): Coker AL, Bond SM, Pirisi, L. Life stressors are an important reason for women discontinuing follow-up care for cervical neoplasia. Cancer Epidemiology Biomarkers and Prevention, 2006:15(2): Du XL, Fang S, Coker AL, Sanderson M, Aragaki C, Cormier JN, Xing Y, Gor BJ, Chan W. Racial Disparity and Socioeconomic Status in Association with Survival in Older Men with Local/Regional Stage Prostate Cancer: Findings From a Large Community- Based Cohort. Cancer. 2006, 106(6): Coker AL, Weston, R. Creson DM, Justice B, Blackley P. PTSD symptoms among men and women survivors of intimate partner violence. Violence & Victims 2005;20(6): Coker AL, Smith, PH, Fadden ML. Partner violence and disabilities preventing work. Journal of Women s Health.2005;14(9): Coker AL. Opportunities for Prevention: Addressing IPV in the Health Care Setting. (Invited) Family Violence Prevention and Health Practice.1: 1-9,

267 26. Sanderson M, Coker AL, Roberts RE. Tortolero SR. Reininger BM. Acculturation, ethnic identity, and dating violence among Latino ninth-grade students. Preventive Medicine. 39(2):373-83, Coker AL. Primary prevention of intimate partner violence for women's health: a response to Plichta. [Review] Journal of Interpersonal Violence. 19(11): , Coker AL, Reeder CE, Fadden MK. Smith PH. Physical partner violence and medicaid utilization and expenditures. Public Health Reports. 119(6):557-67, Times cited: 4; 1 International 29. Sanderson M, Coker AL, Logan P, Zheng W, Fadden MK. Lifestyle and prostate cancer among older African-American and Caucasian men in South Carolina. Cancer Causes & Control. 15(7):647-55, Coker AL, Sanderson M, Dong B. Partner violence during pregnancy and risk of adverse pregnancy outcomes. Paediatric and Perinatal Epidemiology. 18(4):260-9, Times cited: 1, 1 International 31. Boyapati SM, Bostick RM, McGlynn KA, Fina MF, Roufail WM, Geisinger KR, Hebert JR, Coker A, Wargovich M. Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma. Cancer Causes & Control. 15(5): , Times cited: 3; 3 International 32. Coker AL, Sanderson M, Zheng W, Fadden MK. Diabetes mellitus and prostate cancer risk among older men: population-based case-control study. British Journal of Cancer. 90(11):2171-5, Times cited: 5; 3 International 33. Slashinski MJ, Coker AL, Davis KE. Physical aggression, forced sex, and stalking victimization by a dating partner: an analysis of the National Violence Against Women Survey. Violence & Victims. 18(6): , * 34. Coker AL, Watkins KW, Smith PH, Brandt HM. Social support reduces the impact of partner violence on health: application of structural equation models. Preventive Medicine. 37(3):259-67, Times cited: 5; 3 International 35. Coker AL, Bond S, Madeleine MM, Luchok K, Pirisi L. Psychosocial stress and cervical neoplasia risk. Psychosomatic Medicine. 65(4):644-51, Times cited: 2; 1 International 36. Boyapati SM, Bostick RM, McGlynn KA, Fina MF, Roufail WM, Geisinger KR, Wargovich M, Coker A, Hebert JR. Calcium, vitamin D, and risk for colorectal adenoma: dependency on vitamin D receptor BsmI polymorphism and nonsteroidal antiinflammatory drug use?. Cancer Epidemiology, Biomarkers & Prevention. 12(7):631-7, 2003.* Times cited: 6; 2 International 37. Coker AL, Davis KE. Arias I. Desai S. Sanderson M. Brandt HM. Smith PH. Physical and mental health effects of intimate partner violence for men and women. American Journal of Preventive Medicine. 23(4):260-8, Times cited: 34, 10 International 10

268 38. Smith PH, Thornton GE, DeVellis R, Earp J, Coker AL. A population-based study of the prevalence and distinctiveness of battering, physical assault, and sexual assault in intimate relationships. Violence Against Women. 8(10): , Times cited: Davis KE, Coker AL, Sanderson M. Physical and mental health effects of being stalked for men and women. Violence & Victims. 17(4):429-43, Times cited: Coker AL, Smith PH, Thompson MP, McKeown RE, Bethea L, Davis KE. Social support protects against the negative effects of partner violence on mental health. Journal of Women s Health & Gender-Based Medicine. 11(5):465-76, Times cited: 20; 5 International 41. Coker AL, Bond SM, Williams A, Gerasimova T, Pirisi L. Active and passive smoking, high-risk human papillomaviruses and cervical neoplasia. Cancer Detection & Prevention. 26(2):121-8, Times cited: 8; 2 International 42. Coker AL, Bethea L, Smith PH, Fadden MK, Brandt HM. Missed opportunities: intimate partner violence in family practice settings. Preventive Medicine. 34(4):445-54, 2002.Times cited: Ellison GL, Coker AL, Hebert JR, Sanderson SM, Royal CD, Weinrich SP. Psychosocial stress and prostate cancer: a theoretical model. Ethnicity & Disease. 11(3):484-95, 2001.* Times cited: Richter DL, Harris MJ, Coker AL, Fraser J. Limiting the spread of HIV/AIDS in Sierra Leone: opportunities for intervention. Journal of the Association of Nurses in AIDS Care. 12(5):48-54, Times cited: Coker AL, Sanders LC, Bond SM, Gerasimova T, Pirisi L. Hormonal and barrier methods of contraception, oncogenic human papillomaviruses, and cervical squamous intraepithelial lesion development. Journal of Womens Health & Gender-Based Medicine. 10(5):441-9, Times cited: 3; 3 International 46. Akerman GS, Tolleson WH, Brown KL, Zyzak LL, Mourateva E, Engin TS, Basaraba A, Coker AL, Creek KE, Pirisi L. Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mrna levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes. Cancer Research. 61(9): , Times cited: 14; 7 International 47. Coker AL, Gerasimova T, King MR, Jackson KL, Pirisi L. High-risk HPVs and risk of cervical neoplasia: a nested case-control study. Experimental & Molecular Pathology. 70(2):90-5, Times cited: 2, 2 International 48. Coker AL, Russell RB, Bond SM, Pirisi L, Liu Y, Mane M, Kokorina N, Gerasimova T, Hermonat PL. Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia. Experimental & Molecular Pathology. 70(2):83-9, Times cited:10; 5 International 11

269 49. Coker AL, Pope BO, Smith PH, Sanderson M, Hussey JR. Assessment of clinical partner violence screening tools. Journal of the American Medical Womens Association. 56(1):19-23, Times cited: 14; 2 International 50. Coker AL, Sanderson M, Fadden MK, Pirisi L. Intimate partner violence and cervical neoplasia. Journal of Women s Health & Gender-Based Medicine. 9(9): , Times cited: 6; 2 International 51. Coker AL, Derrick C, Lumpkin JL, Aldrich TE, Oldendick R. Help-seeking for intimate partner violence and forced sex in South Carolina. American Journal of Preventive Medicine. 19(4):316-20, Times cited: Coker AL, McKeown RE, Sanderson M, Davis KE, Valois RF, Huebner ES. Severe dating violence and quality of life among south carolina high school students. American Journal of Preventive Medicine. 19(4):220-7, Times cited: 39; 6 International 53. Burgos M, Reininger B, Richter DL, Coker AL, Alegria M, Vera M, Saunders R. Correlates of sexually transmitted infections among street-based female adolescent sex workers in Puerto Rico: Implications for community health. International Quarterly of Community Health Education. 20(3): , 2001.* 54. Coker AL, Smith PH, Bethea L, King MR, McKeown RE. Physical health consequences of physical and psychological intimate partner violence. Archives of Family Medicine. 9(5):451-7, Times cited: 83; 13 international 55. Oldendick R, Coker AL, Wieland D, Raymond JI, Probst JC, Schell BJ, Stoskopf CH. Population-based survey of complementary and alternative medicine usage, patient satisfaction, and physician involvement. South Carolina Complementary Medicine Program Baseline Research Team. Southern Medical Journal. 93(4):375-81, Times cited: 39; 10 International 56. Coker AL, Smith PH, McKeown RE, King MJ. Frequency and correlates of intimate partner violence by type: physical, sexual, and psychological battering. American Journal of Public Health. 90(4):553-9, Times cited: 79; 13 International 57. Nelson JH, Hawkins GA, Edlund K, Evander M, Kjellberg L, Wadell G, Dillner J, Gerasimova T, Coker AL, Pirisi L, Petereit D, Lambert PF. A novel and rapid PCRbased method for genotyping human papillomaviruses in clinical samples. Journal of Clinical Microbiology. 38(2):688-95, Times cited: 12; 8 International 58. Cokkinides VE, Coker AL, Sanderson M, Addy C, Bethea L. Physical violence during pregnancy: maternal complications and birth outcomes. Obstetrics & Gynecology. 93(5 Pt 1):661-6, 1999.* Times cited: 49; 19 International 59. Coker AL, Derrick C, Lumpkin J, Oldendick R, Potter RH. Intimate partner violence in South Carolina, Morbidity and Mortality Weekly Report (MMWR).49(30): , Times cited: 4 12

270 60. Burgos M, Richter DL, Reininger B, Coker AL, Saunders R, Alegria M, Vera M. Streetbased female adolescent Puerto Rican sex workers: Contextual issues and health needs. Family & Community Health. 22(2):59-71, 1999.* Times cited: 3; 1 International 61. Cokkinides VE, Coker AL. Experiencing physical violence during pregnancy: Prevalence and correlates. Family & Community Health. 20(4):19-37, 1998.* Times cited: 16; 4 International 62. Coker AL, Patel N, Krishnawami S, Schmidt W, Richter D. Childhood forced sex and cervical neoplasia among women prison inmates. Violence Against Women. 4(5): , Times cited: Coker AL, Walls L, Johnson JE. Traumatic physical injury during sexual assaults: Frequency and correlates for men and women. Journal of Interpersonal Violence. 13(5): , Times cited: Coker AL, Richter DL. Violence against women in Sierra Leone: frequency and correlates of intimate partner violence and forced sexual intercourse. African Journal of Reproductive Health. 2(1):61-72, Times cited: 18; 5 International 65. McDermott S, Coker AL, Mani S, Krishnaswami S, Nagle RJ, Barnett-Queen LL, Wuori DF. A population-based analysis of behavior problems in children with cerebral palsy. Journal of Pediatric Psychology. 21(3):447-63, 1996 * Times cited: 6; 1 International 66. Bachman R, Coker AL. Police involvement in domestic violence: the interactive effects of victim injury, offender's history of violence, and race. Violence & Victims. 10(2):91-106, Times cited: Boardley DJ, Sargent RG, Coker AL, Hussey JR, Sharpe PA. The relationship between diet, activity, and other factors, and postpartum weight change by race. Obstetrics & Gynecology. 86(5):834-8, 1995.* Times cited: 49; 13 International 68. Bagwell MA, Thompson SJ, Addy CL, Coker AL, Baker ER. Primary infertility and oral contraceptive steroid use. Fertility & Sterility. 63(6):1161-6, 1995.* Times cited: 7; 4 International 69. Slatkoff SF, Curtis P, Coker A. Patients as subjects for research: ethical dilemmas for the primary care clinician-investigator. Journal of the American Board of Family Practice. 7(3): , Times cited: Weinrich S, Coker AL, Weinrich M, Eleazer GP, Greene FL. Predictors of Pap smear screening in socioeconomically disadvantaged elderly women. Journal of the American Geriatrics Society. 43(3):267-70, Times cited: 12, 2 International 71. Coker AL, Richter DL, Valois RF, McKeown RE, Garrison CZ, Vincent ML. Correlates and consequences of early initiation of sexual intercourse. Journal of School Health. 64(9):372-7, Times cited: 49, 4 International 13

271 72. Bustan MN, Coker AL. Maternal attitude toward pregnancy and the risk of neonatal death. American Journal of Public Health. 84(3):411-4, 1994.* Times cited: 22; 7 International 73. Coker AL, Jenkins GR, Busnardo MS, Chambers JC, Levine LZ, Pirisi L. Human papillomaviruses and cervical neoplasia in South Carolina. Cancer Epidemiology, Biomarkers & Prevention. 2(3):207-12, Times cited: 13; 3 International 74. Bustan MN, Coker AL, Addy CL, Macera CA, Greene F, Sampoerno D. Oral contraceptive use and breast cancer in Indonesia. Contraception. 47(3):241-9, 1993.* Times cited: 3; 2 International 75. McDermott SW, Coker AL, McKeown RE. Low birth weight and mild mental retardation at age five and nine to eleven. Paediatric & Perinatal Epidemiology. 7: , 1993.* Times cited: Coker AL, Harlap S, Fortney JA. Oral contraceptives and reproductive cancers: weighing the risks and benefits. Family Planning Perspectives. 25(1):17-21, 36, Times cited: 11; 1 International 77. Coker AL, Rosenberg AJ, McCann MF, Hulka BS. Active and passive cigarette smoke exposure and cervical intraepithelial neoplasia. Cancer Epidemiology, Biomarkers & Prevention. 1(5):349-56, Times cited: 24; 12 International 78. Coker AL, McCann MF, Hulka BS, Walton LA. Oral contraceptive use and cervical intraepithelial neoplasia. Journal of Clinical Epidemiology. 45(10):1111-8, Times cited: Coker AL, Hulka BS, McCann MF, Walton LA. Barrier methods of contraception and cervical intraepithelial neoplasia. Contraception. 45(1):1-10, Times cited: 7; 4 International 80. Beresford SA, Coker AL. Pictorially assisted recall of past hormone use in case-control studies. American Journal of Epidemiology. 130(1):202-5, 1989 Jul. Times cited: 19; 3 International BOOK CHAPTERS, PROCEEDINGS, AND OTHER PUBLICATIONS 81. Coker, AL. Preventing IPV: How we will rise to this challenge. Am J Prev Med Am J Prev Med Jun;30(6): (Invited Commentary) 82. Coker AL, Smith PH, Flerx VC, Whitaker DP, Fadden MK, Williams M. Design and implementation of the Domestic Violence Services in Rural Clinics Intervention. Preventing Intimate Partner Violence and Sexual Violence in Racial / Ethnic Minority Communities: CDC s Demonstration Projects. Editors: D Whitaker, L Reese. CDC, Sept 2006, pages Burgos M, Reininger B, Richter DL, Coker AL, Alegria M, Vera M, Saunders R. Assessing the interrelationships of STIs, substance abuse, and depression among streetbased female adolescent sex workers in Puerto Rico: Implications for community health. 14

272 Torres, MIdali Cernada, George P (Eds). (2003). Sexual and reproductive health promotion in Latino populations: Parteras, promotoras y poetas: Case studies across the Americas. (pp ). Amityville, NY, US: Baywood Publishing Co, Inc. xi, 352 pp 84. Coker AL, Crane MM, Sticca RP, Sepkovic DW. Re: Ethnic differences in estrogen metabolism in healthy women.[letter] Journal of the National Cancer Institute. 89(1):89-90, Times cited: Grubb GS, Coker A. Re: "Condyloma and Intraepithelial Neoplasia of the Uterine Cervix: a Case-Control Study". [Letter] American Journal of Epidemiology. 130(2):427-9, Times cited: Stasny EA, Coker AL. Adjusting the National Crime Victimization Survey s Estimates of Rape and Domestic Violence for Gag Factors in Reporting. Technical Report #592, Department of Statistics, Ohio State University, Invited manuscripts and presentations Coker AL. Role of Family Physician in Stopping Family Violence. Texas Academy Family Practitioners. Annual Meeting, The Woodlands, Texas, Oct 28, Coker AL. Dating violence: Frequency, risk factors and health consequences. 6 th Annual Southern States Knowledge Conference: Youth Violence Prevention, San Antonio, Texas, March 31, Coker AL. Opportunities for Prevention: Addressing IPV in the Health Care Setting. (Invited) Family Violence Prevention and Health Practice.1: 1-9, Coker AL. Primary prevention of intimate partner violence for women's health: a response to Plichta. [Review] Journal of Interpersonal Violence. 19(11): , Coker AL. Clinic-based IPV assessment in rural South Carolina: Results from baseline survey, Presentation, Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, Smith PH, Coker AL. Alternative methods of assessing IPV in clinical settings, Presentation, Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, 2004 Coker AL. Shaping the direction of family violence research. Primary Prevention. (Invited lecture for plenary session). Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, Coker AL. University of Kentucky s Center for Research on Violence Against Women. Invited discussant for invited paper on Intimate Partner Violence and Physical Health Consequences presented by Stacey B. Plichta, Oct 18,

273 Coker AL. Invited presenter and discussant. National Academy of Sciences Violence Against Women Workshop, Primary Prevention of Partner Violence. Washington, DC, Jan 4-5, Coker AL. Measuring the Public Health Impact of Intimate Partner Violence: Frequency, Correlates, and Health Outcomes. Invited Lecture, Safe USA Conference, Atlanta, GA, Dec 3, Coker AL. Invited presentation to USC Greenville Campus medical residents. Screening for Intimate Partner Violence, May 14, Coker AL. Invited participant in The National Violence Against Women Research Workshop, May 1-3, 2001, Atlanta, GA, sponsored by CDC and NIJ. Coker AL. Invited participant at NCI sponsored workshop Reducing Health Disparities in High Cervical Cancer Mortality Regions, in Corpus Christi TX, Nov 28-29, PRESENTATIONS AT SCIENTIFIC AND PROFESSIONAL MEETINGS, since 2000 (*Indicates student/post-doctoral fellow was presenter) INTERNATIONAL Coker AL, Sanderson M, Fadden MK. Psychological stress, coping and prostate cancer, Poster, Abstract published in American Journal of Epidemiology, 2005;1161(11):#058S, Society for Epidemiologic Research, Toronto, Canada, June 27-30, Meyer T, Coker AL, Sanderson M, Symanski E. Reduction of exposure misclassification in a case-control study of farming related exposures and prostate cancer, Poster, Abstract published in American Journal of Epidemiology, 2005;1161(11):#086S.Society for Epidemiologic Research, Toronto, Canada, June 27-30, 2005.* Aragaki CC, Sanderson M, Coker A, Cai Q, Hayes R, Zheng W. Aryl hydrocarbon receptor SNP AHR modifies the effect of pesticide use on prostate cancer in South Carolina, Presentation, Abstract published in American Journal of Epidemiology, 2005;1161(11):#382, Society for Epidemiologic Research, Toronto, Canada, June 27-30, Eggleston K, Coker A, Williams M, Tortolero-Luna G, Martin J, Tortolero S. Ethnicity, poverty, rural residence and cervical cancer survival in Texas, , Presentation, Abstract published in American Journal of Epidemiology, 2005;1161(11):#174, Society for Epidemiologic Research, Toronto, Canada, June 27-30, Sanderson M, Coker AL, Perez A, Fadden MK. A multilevel analysis of socioeconomic status and prostate cancer risk, Presentation, Abstract published in American Journal of 16

274 Epidemiology, 2005;1161(11):#171. Society for Epidemiologic Research, Toronto, Canada, June 27-30, Hazlett L, Coker AL, Pirisi L, Bond SM, Burke R. Bacterial vaginosis, Chlamydia trachomatis and High Risk HPV Persistence, Poster: P-61, 22 nd International Papillomavirus Conference Vancouver, BC, May 1-5, 2005.* Brandt H, Coker A, Sanderson M, Olson C. Clinical communication of HPV: A qualitative study, Poster: P-465, 22 nd International Papillomavirus Conference, Vancouver, BC, May 1-5, 2005.* McCurdy S, Lopez A, Coker A, Sanderson. Patient knowledge of HPV along the US-Mexico border. 22 nd International Papillomavirus Conference, Poster: P-471, Vancouver, BC, May 1-5, 2005.* Brandt HB, McCree D, Coker A, Sharpe P. An evaluation of HPV educational materials, Poster, International Papillomavirus Conference, Paris, France, Oct 4-9, 2002.* Coker AL, Bond SM, Pirisi LA. Stressful life events and risk of HPV persistence, Poster, Abstract published in Am J Epidemiol 2001;153(11): S214 (#785), First North American Congress of Epidemiology, Toronto, Canada, June 15, Coker AL, Davis KE, Arias I, Desai S, Smith PH, Sanderson M. Health effects of intimate partner violence on men and women, Presentation, International Family Violence Meeting, Portsmouth NH, July 25-28, Coker AL, Bond SM, Madeline MM, King M, Gerasimova T, Pirisi L. Stressful life events and risk of HR-HPV persistence, Presentation, International Papillomavirus Conference, Florianopolis, Brasil, Sept 1-7, Coker AL, Bond SM, Pirisi L, Liu Y, Mane M, Kokorina N, Gerasimova T, Hermonat P. Adeno-associated virus is associated with a lower risk of high grade cervical neoplasia, Poster, International Papillomavirus Conference, Florianopolis, Brasil, Sept 1-7,

275 PRESENTATIONS AT SCIENTIFIC AND PROFESSIONAL MEETINGS, since 2000 (*Indicates student/post-doctoral fellow was presenter) NATIONAL Coker AL, Smith PH, Flerx V, Whitaker D. Correlates of help seeking among rural women experiencing partner violence, Presentation, 9 th International Family Violence Research Conference, Portsmouth, NH, July 11, Coker AL, Sanderson M, Cantu E. Dating violence among Mexican-American College Students, Presentation, 9 th International Family Violence Research Conference, Portsmouth, NH, July 12, Coker AL. Clinic-based IPV assessment in rural South Carolina: Results from baseline survey, Presentation, Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, Smith PH, Coker AL. Alternative methods of assessing IPV in clinical settings, Presentation, Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, Coker AL. Shaping the direction of family violence research. Primary Prevention. (Invited lecture for plenary session). Family Violence Prevention Fund s 2004 National Conference on Health Care and Domestic Violence, Boston, MA, Oct. 23, Coker AL. University of Kentucky s Center for Research on Violence Against Women. Invited discussant for invited paper on Intimate Partner Violence and Physical Health Consequences presented by Stacey B. Plichta, Oct 18, Coker AL, Sanderson M, Fadden MK. Diabetes Mellitus and Prostate Cancer Risk among Older Men: population-based case-control study, Poster, Abstract published in the American Journal of Epidemiology, June 2004, supplement, Society for Epidemiologic Research Salt Lake City, UT, June 15, Johnson MG, Coker AL, Moore CG, Bolick- Aldrich S. Poverty and Cervical Cancer Survival Among South Carolina Women, Presentation, Abstract published in American Journal of Epidemiology June 2004, supplement, Society for Epidemiologic Research Salt Lake City, UT, June 16, 2004.* Smith PH, Coker AL, Flerx V, Whitaker D. Clinic based IPV assessment in rural South Carolina: Methods for assessing for battering and physical assault, Presentation, American Public Health Association, Washington, DC, Nov 8, Flerx V, Coker AL, Smith PH, Whitaker D. Clinic based IPV assessment in rural South Carolina: Challenges to implementation of a health care response, Presentation, American Public Health Association, Washington, DC, Nov 8,

276 Coker AL, Smith PH, Flerx V, Whitaker D. Clinic based IPV assessment in rural South Carolina: Results from baseline survey, Presentation, American Public Health Association, Washington, DC, Nov 8, Abbott JM, Luchok KJ, Corwin SJ, Coker AL, Prabhu Das I. Competing life priorities for lowincome women who have abnormal Pap test results, Presentation, American Public Health Association, Washington, DC, Nov 8, Luchok KJ, Modayil M, Abbott JM, Brandt HM, Prabhu Das I, Coker AL. Congruence between clinician and client perspectives on factors affecting follow-up of abnormal Pap test results, Presentation, American Public Health Association, Washington, DC, Nov 8, Abbott JM, Luchok KJ, Corwin SJ, Coker AL, Prabhu Das, I. Racial differences among women coping with abnormal Pap test results, Presentation, American Public Health Association, Washington, DC, Nov 8, Coker AL, Smith PH, Flerx V, Fadden MK, Whitaker D. Screening and interventions with victims of intimate partner violence in primary care clinics in rural South Carolina, Poster, American Public Health Association, Washington, DC, Nov 9, Coker AL. Using structural equation models in evaluating intimate partner violence interventions. Symposium: Evaluating Multi-component intervention to Prevent Intimate Partner Violence, Presentation; session #1183, Abstract published in proceedings. American Psychological Association, Honolulu, Hawaii, July 28, Luchok KJ, Coker AL, Abbott JM, Prabhu Das I. Clinician Communication of Abnormal Pap Test Results to Women Patients. Heather M. Brandt, Presentation, American Public Health Association Annual meeting, San Francisco, CA, Nov Abbott JM, Luchok KJ, Coker AL, Prabhu Das I. Understanding Lack of Pap Follow-up: Women Patients Perspectives, Presentation, Abstract published in proceedings, American Public Health Association Annual meeting, San Francisco, CA, Nov Prabhu Das I, Coker AL, Luchok KJ, Abbott JM, Otterness C. Understanding lack of adherence to Pap follow-up: What do we know? What Next?, Presentation, Abstract published in proceedings, American Public Health Association Annual meeting, San Francisco, CA Nov Luchok KJ, Brandt HM, Coker AL, Abbott JM, Prabhu Das I. Clinician Perspectives on Barriers to Timely Follow-up of Abnormal Pap Test Results, Presentation, Abstract published in proceedings, American Public Health Association Annual meeting, San Francisco, CA, Nov

277 Coker AL, Luchok KJ, Prabhu Das I, Abbott JM, Otterness C. Understanding Lack Of Pap Follow-up: Qualitative Approach, Presentation, Abstract published in proceedings, American Public Health Association Annual meeting, San Francisco, CA, Nov Coker AL, Bond SM, Brand HM. Reasons women discontinue paid follow-up care for preinvasive cervical neoplasia, Poster, Abstract published in American Journal of Epidemiology, 2002;155(11) Supplement page S3. Society for Epidemiologic Research, Palm Desert, CA, June 18-21, Coker AL, Watkins KW. How does partner violence impact health?, Poster, Abstract published in American Journal of Epidemiology, 2002;155(11) Supplement page S45, Society for Epidemiologic Research, Palm Desert, CA, June 18-21,2002. Brandt HM, Ureda JR, Otterness C, Coker AL. Transition to Medicare-funded mammography from an income-eligible screening program, Presentation, American Public Health Association, 129 th Annual meeting, Atlanta, GA, Oct 21-25, 2001.* Burgos MM, Reininger BM, Richter DL, Alegría M, Vera, M, Coker AL, Saunders RE. Addressing the Health Needs of Adolescent Sex Workers in Puerto Rico, Presentation, American Public Health Association, 129 th Annual meeting, Atlanta, GA, Oct 21-25, Burgos MM, Richter DL, Reininger BM, Alegría M, Vera, M, Coker AL, Saunders RE. Correlates of Sexually Transmitted Infections Among Street-Based Adolescent Female Sex Workers in Puerto Rico, Poster, American Public Health Association, 129 th Annual meeting, Atlanta, GA, Oct 21-25, Brandt HM, Ureda JR, Otterness C, Coker AL. Relationship of the Perceived Stress Scale to salivary cortisol in family caregivers of older adults, Presentation, American Public Health Association, 129 th Annual meeting, Atlanta, GA, Oct 21-25, 2001.* Coker AL. Measuring the Public Health Impact of Intimate Partner Violence: Frequency, Correlates, and Health Outcomes. Invited Lecture, Safe USA Conference, Atlanta, GA, Dec 3, Coker AL, Flerx VC, Smith PH. Domestic violence care in rural health clinics, Poster, Safe USA Conference, Atlanta, GA, Dec 3, Brandt HM, Ureda JR, Coker AL. An examination of low-income, older women's intentions to have a mammogram and use Medicare Part B to pay for screening mammograms, Poster, Abstract published in proceedings: #921, American Public Health Association Annual meeting, Boston, MA, November 13, 2000.* 20

278 Coker AL. Physical health consequences of physical and psychological intimate partner violence, Presentation, Abstract published in conference proceedings, National Conference on Health Care and Domestic Violence, San Francisco, CA. Oct 13-14, Coker AL, Bond SM, King MR, Ferasimova T, Pirisi AL. Recent psychological stress, HPV and cervical neoplasia, Presentation, Abstract published in American Journal of Epidemiology 2000;151(11):S50 (#200), Society for Epidemiologic Research, Seattle, WA, June 15-17, Ellison GL, Coker AL, Sanderson M, Hebert JER, Weinrich SP, Lipsitz S. Psychological stress, coping and prostate cancer, Presentation, Abstract published in American Journal of Epidemiology 2000;151(11):S52 (#207), Society for Epidemiologic Research, Seattle, WA, June 15-17, 2000.* MANUSCRIPTS REVIEWED OR REFEREED Journals Archives of Pediatrics and Adolescent Medicine Aggressive Behavior AIDS Prevention Annals of Epidemiology Journal of American Medical Association American Journal of Police The Lancet Violence Against Women British Journal of Cancer American Journal of Public Health Preventive Medicine American Journal of Preventive Medicine Journal of Social and Personal Relationships Violence & Victims Journal of Women s Health and Gender-Based Medicine African Journal of Reproductive Health Diabetes Medicine International Journal of Family Planning Perspectives Journal of Interpersonal Violence Journal of Infectious Disease 21

279 TEACHING University of Texas School of Public Health PH2710 Advanced Methods in Epidemiology 1 (Core epidemiology methods course for masters and doctoral students) PH 2998 Cancer Epidemiology and Prevention PH Violence in America: A Public Health Perspective (Rice University HEAL 498) University of South Carolina School of Public Health EPID 700 Introduction to Epidemiology (For non-majors); Revised course and taught for 9 years including a recent revision for distance education EPID 701 Concepts and Methods of Epidemiology (Introductory course for majors); Taught this course for two years EPID 745 Epidemiology Seminar; Taught this course for two years EPID 746 Cancer Epidemiology; Revised course and taught course for 8 years EPID 742 Epidemiologic concepts in selected disease or health conditions; Taught this course for two years; provided lectures for the course for 8 years EPID 711 Epidemiologic Research Methods (Intermediate epidemiology methods); Developed and taught this course for 4 years. EPID 741 Epidemiologic Methods (Advanced methods); Served as co-instructor and preceptor for 3 years EPID 800/801 Epidemiologic Methods II/III (Doctoral level courses); Taught the courses once and have provided lectures for the courses for two years. EPID 794 Selected topics in Epidemiology: Violence Against Women; Developing this course INFORMAL TEACHING Chair of 5 completed doctoral dissertations in Epidemiology Kristina M. Walker, PhD candidate (UTHSC) Tamra E. Meyer, PhD candidate (UTHSC) Mala Pande, PhD candidate (UTHSC) Kelly Merriman, PhD candidiate (UTHSC) Linda R. Hazlett, PhD, 2004 (USC) Gary Ellison, PhD, 2000 (USC) Abbas Tavakoli, PhD, 1997 (USC) Vilma Cokkinides, PhD, 1999 (USC) N. Mohammed Bustan, PhD, 1994 (USC) 22

280 Chair of 27 completed masters (MSPH) theses in epidemiology Jose Mejia, 1991 (USC) Myriam Torres, 1991 (USC) Allison Rosenberg, 1991(USC) Gavin Welch, 1991 (USC) Lori Ziff, 1992 (USC) INFORMAL TEACHING (continued) Chair of 27 completed masters (MSPH) theses in epidemiology (continued) Susan Knight, 1992 (USC) Brenda Parker, 1993 (USC) Janet Grubber, 1994 (USC) Wendy Schmidt, 1994 (USC) Timothy Cowan, 1994 (USC) Emily Nabors, 1994 (USC) Gayle Tyler-Stukes, 1995 (USC) Emily Nabors, 1994 (USC) Melissa Remsburg (King), 1996 (USC) Virginie Daguise, 1996 (USC) Lucille Walls, 1996 (USC) Gretha Davis, 1996 (USC) Lynn Damarco, 1996 (USC) Laura Cave, 1998 (USC) Cheryl Rogers, 1998 (USC) Avis Johnson, 1999 (USC) Brian Pope, 2000, (USC) Rebecca Russell, 2000 (USC) Farrah Verstradt, 2002 (USC) Mary G. Johnson, 2003 (USC) Mala Pande, 2003 (UTHSC) Katherine Eggleston, 2004 (UTHSC) Elizabeth Camp, 2005 (UTHSC) Liqian Lin, 2005 (UTHSC) Carissa Eastham, 2006 (UTHSC) 23

281 INFORMAL TEACHING (continued) Committee Member on 13 doctoral and 7 master s completed committees Alexandra Connelly, MS, Epidemiology (USC) Woodrow Coker, MSPH, Epidemiology (USC) Kristen Hazel, MSPH, Epidemiology (USC) Frances Logan, MSPH, Epidemiology (USC) Semilla Rivera, MS, Epidemiology (UTHSC) Aroub Khleif, MPH, Disease Control (UTHSC) Vicki Flerx, PhD, Health Promotion and Education (USC) Suzanne McDermott, PhD, Health Administration (USC) Mary Ann Bagwell, PhD, Epidemiology (USC) Angela Pereira, PhD, Social Work (USC) Leslie Ochs, PhD, Health Promotion (USC) Heather Brandt, MSPH and PhD Health Promotion (USC) Margarita Burgos, PhD, Health Promotion (USC) Deborah Thomas, PhD, Geography (USC) Qin Dai, PhD, Epidemiology (USC) Committee Member on 13 doctoral and 7 master s completed committees (continued) Tonji Durant, PhD, Sociology (USC) Sonia Boyapati, PhD, Epidemiology (USC) Sean Firth, PhD, Epidemiology (UTHSC) Jennifer Wood, PhD, Epidemiology (UTHSC) PROFESSIONAL SERVICE, SINCE 2000 National: 2003-Present 2004-Present Epidemiologic Perspectives & Innovations (ejournal), Editorial Board Family Violence Prevention and Health Practice (ejournal) Editorial Board National Cancer Institute, Cancer Centers, Site Visit Team 2004 American Public Health Association; Epidemiology Program Committee, Abstract reviewer 2003 Society for Epidemiologic Research Meeting Abstract reviewer Present Advisory Board, Family Violence Prevention Fund 2003-Present Initial Review Group (Study Section Member), Centers for Disease Control and Prevention, National Center for Injury Prevention and Control PROFESSIONAL SERVIVE, SINCE 2000 (continued) 24

282 National Violence Against Women Prevention Research Center Advisory Board. Consortium between the Medical University of South Carolina, the University of Missouri, and Wellesley College, Member Invited presenter and discussant. National Academy of Sciences Violence Against Women Workshop, Primary Prevention of Partner Violence. Washington, DC National Cancer Institute Special Emphasis Panel, Vaccine Trials 2001 Invited participant in The National Violence Against Women Research Workshop, Atlanta, GA, sponsored by CDC and NIJ ASPH/CDC/ATSDR Grant Reviewer 2001 Invited participant at NCI sponsored workshop Reducing Health Disparities in High Cervical Cancer Mortality Regions, in Corpus Christi TX National Institutes of Health, Special Emphasis Panel, Small Grants in Epidemiology Program 2000 National Action Plan on Cervical Cancer, Advisor to South Carolina Department of Health and Environmental Control 2000 DHHS Public Health Service Advisory Committee for Injury Prevention and Control, Violence Against Women Program. Invited speaker for the committee on CDC funded research Mental and physical health effects of partner violence American Statistical Association, Committee on Law and Justice Statistics, Member State: 2002-Present 2003-Present Texas Cancer Council, Member, Work Group, Texas Cancer Plan. Texas Cancer Registry, Work Group, Co-Chair of the Data Utilization Workgroup South Carolina Department of Health and Environmental Control, Sexual and Physical Assault Prevention Program (CDC funded), Consultant PROFESSIONAL SERVICE, SINCE 2000 (continued) 25

283 Cancer Cluster Resource Network advisory member (organized by American Cancer Society) South Carolina Department of Health and Environmental Control, Cancer Control Advisory Committee - Surveillance Sub-Committee Member 2001 Invited presentation to University of South Carolina Greenville Campus medical residents. Screening for Intimate Partner Violence 2000 South Carolina Medical Association invited lecture at the annual meeting, Title: Prostate Cancer Epidemiological Considerations. University 2004 UTHSC-H Grant 101/102 Mentor 2003 Tenure and Promotion reviewer (Faculty at Georgetown University) Baseline Research Committee for the University of South Carolina Richland Memorial Hospital Complementary / Alternative Medicine (CAM) Research Initiative. This involved creating a survey of consumers of CAM products and interviewing, Co-Chair Dean Search Committee, University of South Carolina, Member South Carolina Cancer Center, Executive Committee, Member South Carolina Cancer Center Public Health Task Force, Member 2001 University of South Carolina, Post tenure reviewer 2000 University of South Carolina, Search Committee, Graduate Director, Women s Studies Women s Studies Affiliate Faculty, University of South Carolina University of Texas School of Public Health Epidemiology Division Representative, Admissions Committee, Member 2003-Present Epidemiology Division, Faculty Council Representative 2004-Present Faculty Council Annual Activities Review Evaluation Committee, Chair PROFESSIONAL SERVIVE, SINCE 2000 (continued) 2004-Present Epidemiology Division, Leadership Team 26

284 Epidemiology Discipline, Faculty Search Committee, Member 2003 NIOSH Pilot Project Research Training Program reviewer, UTHSC-H SPH 1997 Pilot Research Investigations with Mentoring for Excellence (PRIME) Grant University of Texas School of Public Health 2002 Epidemiology Discipline, Curriculum Committee, Co-Chair 2000 Department of Epidemiology and Biostatistics, Chair Search Committee, Member, University of South Carolina 27

285 Curriculum Vitae Date Prepared: March 10, 2008 Douglas T. Steinke, PhD Assistant Professor (regular title series) College of Pharmacy, University of Kentucky I. General Information Home address: 361 Colony Blvd., Lexington, KY, Home telephone: Office address: 725 Rose St, Lexington, KY, Office telephone: Office fax: Social security number Provided on request Registration Ontario College of Pharmacy (Part B) Nationality Canada, Great Britain, US Permanent Resident II. Education 1982 BSc. (Chemistry) University of Winnipeg, Canada 1986 BSc (Pharmacy) University of Manitoba, Canada 1996 MSc (Community Health and Epidemiology) Queen s University, Canada 1998 HEcon Cert (Health Economics) University of Aberdeen, Scotland 2001 PhD (Pharmacoepidemiology) University of Dundee, Scotland 2002 Post-Doctorate Epidemiology of Liver Disease in Tayside (ELDIT), Dundee III Academic Appointments Joint appointment - College of Public Health, Dept. of Epidemiology Assistant Professor, College of Pharmacy, University of Kentucky, USA Associate member of the Graduate Faculty, University of Kentucky Honorary Lecturer, University of Strathclyde, Dept. of Pharmaceutical Sciences, Glasgow, Scotland. IV Other Appointments Research Pharmacist, Healthcare Information Group, NHS National Services Scotland, Edinburgh, Scotland Research Pharmacist, Medicines Monitoring Unit, University of Dundee, Ninewells Hospital, Dundee, Scotland

286 V Professional Experience Senior Pharmacist, Corrections Canada, Kingston, Canada Staff Pharmacist for various community pharmacies. Kingston, Canada Senior Pharmacist, St. Lucia Health Department, St. Lucia, West Indies. VI Honors 1997 Bayer Fellowship for Pharmacoeconomics and Pharmacoepidemiology, University of Dundee, Scotland 1994 and Queen s Graduate Awards, Faculty of Graduate Studies, Queen s 1995 University, Canada 1986 Doreen Ash Memorial Prize, Faculty of Pharmacy, University of Manitoba VII Teaching activity 2007 Course coordinator for PHR950 Pharmaceutical Policy and Public Health a new course for the professional program in fall semester of Course supervisor for PHR 895 Independent study of Problems in Pharmacy academic year students include: -Jamie Ferrel (PY2) and Vineet Patel (PY2) Impact of drug information technology availablity and utilzation on pharmacy practice in Kentucky. -Kena Lanham (PY3) Healthcare utilization and medication patterns of use in a Type 2 diabetes HMO population. -Brandon Stiff (PY2) Evaluation and monitoring of elevated liver enzymes in patients receiving lipid lowering therapy. -Samatha Mathews (PY3) Domestic animal bites and rabies vaccine administration: a epidemiologic review of the incidence and public policy Resident Rotation, one month rotation with Primary Care Resident, guiding his learning in Outcomes Research and Pharmacoeconomics Teach statistics module for the Pre-registration Pharmacist Programme at the Western General Hospital. Assist with student project design and methology Teach a module in phramceutical public health to undergraduate students in the Department of Pharmaceutical Sciences, University of Stranthclyde Pharmacoeconomics module in the MSc Clinical Pharmacy program. University of Strathclyde, Department of Pharmaceutical Sciences Pharmacoepidemiology and Pharmacoeconomics. With Dr. JMM Evans to students in the BSc(Hons) program in Pharmacology, University of Dundee Taught compounding, pharmaceutical maths and Pharmacology in the Pharmacy Technicians course, Kingston Learning Centre, Kingston, Ontario.

287 VIIa International teaching activity March 2007 Kitasato University, School of Pharmacy, Tokyo, Japan lectured in English to MSc Clinical Pharmacy students in Pharmacoepidemiology for Clinical Pharmacists, Pharmacoeconomics, Epidemiology, Pharmacist Role in Primary Care and Pharmacists in Public Health; the Japanese perspective. This is a faculty/student exchange program with the University of Kentucky College of Pharmacy. VIII Publications (Peer Reviewed) Johnson CL, Nicholas A, Divine H, Perrier D, Blumenschein K, Steinke DT. Outcomes from DiabetesCARE: A Pharmacist provided Diabetes Management Service. Journal of the American Pharmacists Association (in press) DeName B, Divine H, Nicholas A, Steinke DT, Johnson C. Identification of drug therapy problems and health care provider acceptance of pharmacist recommendations in a medication therapy management service. Journal of the American Pharmacists Association (in press) Strunk LB, Matson AW, Steinke DT. Impact of a pharmacist on medication reconciliation upon patient admission to a Veterans Affairs medical center. Hospital Pharmacy (in press) Divine H, Nicholas A, Johnson C, Perrier D, Steinke DT, Blumenschein K. Description of a Pharmacist Care Service and Lessons Learned Along the Way. Journal of the American Pharmacists Association (in press) Nau D, Steinke DT, Williams LK, Austin R, Lafata JE, Divine G, Pladevall M. The concordance of a visual analog scale (VAS) self-report measure of medication adherence with claims-based estimation of adherence. Annals of Pharmacotherapy 2007;41: Vincent W, Steinke DT, Smith K. Opportunities for Pharmacists in Public Health. American Journal of Hospital Pharmacy 2007;64: Clark RC, Maxwell SR, Kerr S, Cuthbert M, Buchanan D, Steinke D, Webb DJ, Bateman ND. The influence of primary care prescribing rates for new drugs on spontaneous reporting of adverse drug reactions. Drug Safety 2007, 30: Donnan PT, McLernon D, Steinke D, Ryder S, Roderick P, Sullivan FM, Rosenberg W, Dillon JF. Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluations (ALFIE). BMC Health Services Research 2007; 7:54.

288 Steinke DT, Burney S, Bennie M, Hudson SA. Using health and population data to help describe the health of a locality: the development and evaluation of a locality health profile. International Journal of Pharmacy Practice 2005; 14: Boyter AC and Steinke DT. Changes in prescribing of inhaled corticosteroids ( ) in Scotland. Pharmacoepidemiology and Drug Safety 2005; 14(3): Donnan PT, Wei L, Steinke DT, Phillips G, Clarke R, Noone A, Sullivan FM, MacDonald TM, Davey PG. Patients prescribed antibiotics in the past 6 months are more likely to have bacteriuria caused by trimethoprim resistant bacteria: multilevel model with practice and individual patient data. British Medical Journal 2004; 328: Smith GD, Steinke DT, Kinnear M, Penny KI, Pathmanathan N, Penman ID. A comparison of Irritable Bowel Syndrome (IBS) patients managed in primary and secondary care: the Epidsode IBS study. British Journal of General Practice, 2004; 54: Steinke D, Weston T, Morris A, MacDonald T, Dillon J. The Epidemiology of Liver Disease in Tayside (ELDIT) database: a population based record linkage study. Journal of Biomedical Informatics 2003; 35: Steinke D, Emslie-Smith A, Boyle P, Young HK, Macfarlane G, Davey P. A population study of first exposure to community antibacterials in children and the suitability of routine urine sample for study of the acquisition of drug resistance. Journal of Antimicrobial Chemotherapy 2002; 50: Donnan PT, Steinke DT, Newton RW, Morris AD. Changes in treatment after the start of oral hypoglycaemic therapy in Type 2 diabetes: a population-based study. Diabetic Medicine 2002; 19: Steinke DT, Weston TL, Morris AD, MacDonald TM, Dillon JF. Epidemiology and economic burden of viral hepatitis: an observational population based study. Gut 2002; 50: Koulentaki M, Renolds N, Steinke D, Tait J, Baxter J, Vaidya K, Jayesakera A, Pennington C. Eight years experience of gastrostomy tube management. Endoscopy 2002; 34: Steinke DT, Seaton RA, Phillips G, MacDonald TM, Davey P. Prior trimethoprim use and trimethoprim-resistant urinary tract infection: a nested case-control study with mulitvariate analysis for other risk factors. Journal of Antimicrobial Chemotherapy 2001; 47: Steinke DT, Davey PG. The association between antibiotic resistace and communtiy prescribing: a critical review of bias and confounding in published studies. Clinical Infectious Diseases 2001; 33 (Suppl 2) S1-S12.

289 Donnan PT, Steinke DT, Stubbings C, Davey PG, MacDonald TM. Selegiline and mortality in subjects with Parkinson s disease: a longitudinal community study. Neurology 2000; 55: Steinke DT, Bain JD, MacDonald T, Davey P. Practice factors that influence antibiotic prescribing in general practice in Tayside. Journal of Antimicrobial Chemotherapy 2000; 46: Seaton RA, Steinke DT, Phillips G, MacDonald T, Davey PG. Community antibiotic therapy, hospitalisation and subsequent respiratory tract isolation of Haemophilus influenzae resistant to amoxycillin: a nested case-control study. Journal Antimicrobial Chemotherapy 2000; 46: Davey P, Steinke D, MacDonald T, Phillips G, Sullivan F. Not so simple cystitis: How should prescribers be supported to make informed decisions about the increasing prevalence of infections caused by drug-resistant bacteria? British Journal of General Practice 2000;50: Steinke DT, MacDonald TM, Davey PG. The doctor-patient relationship and prescribing patterns. A view from primary care. Pharmacoeconomics 1999; 16: Donnan PT, Steinke DT, Wang J, Davey PG, MacDonald TM. Evaluating clinical studies of drug efficacy. JAMA 2000; 1: Steinke DT, Seaton RA, Phillips G, MacDoanld TM, Davey PG. Factors associted with trimethoprim-resistant bacteira isolated from urine samples. Journal of Antibmicrobial Chemotherapy 1999;43: Morris AD, McAlpine R, Steinke D, et al. Diabetes and lower-limb amputations in the community. A retrospective cohort study. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland/ Medicines Monitoring Unit. Diabetes Care 1998;21: McCowat LA, Cutting WA, Steinke D, MacDonald TM. Treating diarrhoea. Children deserve special attention. BMJ 1997;315: Evans JMM, McMahon AD, Steinke DT, McAlpine RR, MacDonald TM. Do H-2- receptor antagonists cause acute pancreatitis? Pharmacoepidemiology and Drug Safety 1998;7: IX Publications (Other) Vincent WR, Wiesner A, Steinke DT. Free Prescription Drug samples Are Not Free. American Journal of Public Health (submitted 10/03/08). [Letter to the Editor]

290 Nau DP, Steinke DT, Elston Lafata J Williams LK, Divine G, Austin R, Pladevall M. Can patients accurately rate their adherence to medications? Value in Health 2007; 10(3): A67. [Abstract] Steinke DT. Prescribing from the American perspective. Cancer Nursing Practice 2005, Vol 4 Num 10 [Commentary letter] Steinke DT. A prescription too far? Gastrointestinal Nursing 2003; 1: [Commentary letter] Steinke DT, Hudson S, Bennie M, Burney S, Mureray P, Bryson S. Development and evaluation of a Local Health Care Co-operative (LHCC) Health Profiles using rotuene primary and secondary care data. European Journal of Public Health 2002;12:99 [Abstract]. Steinke DT, Weston TL, Morris AD, MacDonald TM, Dillon JF. Incidence, prevalence and resource use of primary biliary cirrhosis in Tayside, Scotland. Journal of Hepatology 2001;34:181 [Abstract]. Steinke DT, Dillon JF. Population-based epidemiology of liver enzyme tests: evaluateing normal and abnormal tests in Tayside, Gut 2001; 2001(suppl 1): A105. [Abstract]. Steinke DT, Weston TL, Morris AD, MacDonald TM, Dillon JF. Health resource use ad costs associated with viral hepatitis. Gut 2001; 2001(suppl 1): A107 [Abstract]. Todd JA, Weston T, Steinke D, Johnston DA, Dillon JF. Oesophagitis, a risk factor for oesophageal cancer. Gut 2001; 2001(suppl 1): A8. [Abstract]. Steinke D, Weston T, Morris A, MacDonald T, Dillon J. Population-based epidemiology of viral hepatitis. Gut 2000;46 (Suppl II): A60 [Abstract]. Weston T, Steinke D, Morris A, MacDonald T, Dillon J. The incidence of Liver and intrahepatic bile duct cancer in Tayside, Scotland: A population-based cohort study. Gut 2000; 46 (Suppl II):A62 [Abstract]. Evans J, Ellis J, Steinke D, Donnan P, Morris A. Childhood Type 1 diabetes and parentaloccupation involving parental mixing and infectious contacts. Letter in Diabetic Medicine 2000, 17: 487. D.P. Kofteridis, D. Steinke, G. Barlow, D. Nathwani. Gram positive bloodstream infections. Analysis of 315 episodes of community and hospital acquired bacteraemia. Clinical Microbiology and Infection 2000: 6, Suppl. 1; 62. [Abstract]

291 D. Steinke, P. Donnan, T. MacDonald, P. Davey. Is community antibiotic treatment associated with better outcome of hospitalisation for LRTI? Clinical Microbiology and Infection 2000: 6, Suppl. 1; 191 [Abstract] P. Davey, G. Libby, K. Hunter, J. Broomhall, D. Steinke, D. Yin. Outcomes of treatment of intra-abdominal infections. Clinical Microbiology and Infection 2000: 6, Suppl. 1; 191 [Abstract]. Steinke D, Seaton A, Phillips G, MacDonald T, Davey P. Risk factors associated with trimethoprim resistant bacteria in incident community urine samples. Clinical Microbiology and Infection 5(Supplement 3), [Abstract]. Seaton RA, Steinke DT, Phillips G, MacDonald T, Davey PG. Hospitalisation and community beta-lactam exposure are risk factors for antibiotic resistance in Haemophilus influenzae isolated from the respiratory tract of adults. Clinical Microbiology and Infection 5(Supplement 3), [Abstract]. X Continuing education programs developed Mason-Duff J, Steinke D for the Centre for Pharmacy Postgraduate Education. Public Health: Assessing needs for Pharmacy Development. University of Manchester, 2004 XI Scholarly presentations MK Rayens, J Hahn, M Zhang, K Butler, D Steinke. Effect of a smoke-free law on the community smoking rate. 135 th American Public Health Association Annual meeting, Washington, DC. November 3-7, 2007 DT Steinke, D Hall, C Sargent, C Newell, T Caudill, J Conigliaro. Identification of predictors for ICU admission/readmission after consultation by a rapid response team. The National State of the Science Congress in Nursing Research, Washington, DC, October 12-14, DT Steinke. Pharmacoeconomics Emphasis on Antibiotic Utilisation. An invited lecture and a workshop at the 2 nd International Pharmacy Conference, Muscat, Oman, December 14-16, DT Steinke, S Hudson, S Burney, M Bennie, P Murray, S Bryson. Development and evaluation of a Local Health Care Co-operative (LHCC) pharmaceutical public health profile Eurpean Association of Public Health, Dresden Germany and the 2001 Public Health in Scotland Conference, Turnberry, Scotland. DT Steinke, T Weston, A Morris, T MacDonald, J Dillon. Population-based epidemiology of Alcoholic Liver Disease British Society of Gastroenterology, Birmingham, England.

292 PG Davey, A Walker, DT Steinke. Pharmacoeconomics short course International Society of Pharmacoeconomics and Outcomes Research, Edinburgh, Scotland. DT Steinke. Risk Factors for Antibiotic Resistant Urinary Tract Infections th Congress of Pharmacoepidemiology, Lisbon, Portugal. DT Steinke, A Seaton, G Phillips, TM MacDonald, AD Morris, PG Davey. Impact of Community Antibiotic Prescribing and Hospitalisation on the risk of Urinary Tract Infection with drug-resistant bacteria: A Case Control Study International Society of Pharmacoepidemiology, Orlando, Florida. DT Steinke, DJG Bain, PG Davey, AD Morris, TM MacDonald. Prescribing Differences in Training and Non-Training General Practices is explained by Population Deprivation Score Drug Utilisation Research Group, UK, Dublin, Ireland. XII Grants awarded (Peer review) 2008 Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation, Research Starter Grant in Health Outcomes, Steinke, DT, Talbert J. Project title: Gender disparities in type 2 diabetes medication utilization: a population-based study using Medicaid data Society of Infectious Diseases Pharmacists, Feola DJ, Murphy BS and Rapp (Steinke, DT is epidemiology and biostatistical advisor). Project title: In vivo impact of azithromycin on macrophage phenotype in P. aeruginosa infection American Pharmacists Association Foundation Incentive Grant for Practitioner Innovation in Pharmaceutical Care, Doug Steinke, Bridger DeName. Project title: Identification of Drug Therapy Problems and Prescriber Acceptance of Pharmacist Recommendations in a Medication Therapy Management Service DiabetesCARE Department of Health and Human Services, NIH R21 (2 years support). Kirsh K, Steinke D, Dignon M. Project title: Building Bridges to Hospice and Rural Appalachia The Centers for Disease Control and Prevention. Perrier D, Nicholas A, Devine H, Steinke D., May F. Project title: Improving Medication-Related Outcomes ASHP fostering Young Investigators: Pharmacy Resident Health Services Research Grant. Yam F, Jones M, Steinke D, Adams A, Nicholas A, Divine H, Johnson C. Project title: Clinical Inertia: Time to intervention of critical A1C values in two primary care models for patients with Type 2 Diabetes NHS Health Technology Assessment (HTA ). Donnan PT, Dillon JF, McLernon D, Steinke D, Ryder S, Roderick P, Sullivan F. Project title: Development of

293 a decision support tool to facilitate primary care management of patients with abnormal liver fuction tests without clinically appartent liver disease Lothian Primary Care Research Network. Sue Hudson-Crauford, Patricia Bruns, Doug Steinke. Project title: Investigating the coexistance of alcohol dependence and antidepressant medicine use British Society for Antimicrobial Chemotherapy. Mr. D Steinke, Dr. RA Seaton, Dr. G Phillips, Prof PG Davey. Project title: Does prior antibiotic use explain trimethoprim resistance in urinary tract infections. XII Grants awarded (Consultant to) Feola D, PI American College of Clinical Pharmacy Investigator Development Research Award Immunotoxicity of zidovudine plus sulfamethoxazole-trimethoprim exposure Study period: 10/1/06 to 9/30/07 Feola DJ, Murphy BS, and Rapp RP. Society of Infectious Diseases Pharmacists - Infectious Diseases Pharmacotherapy Research Award. In vivo impact of azithromycin on macrophage phenotype in P. aeruginosa infection. Study period: XII Grants awarded (Mentor to) Jennifer Gatz, Post Doctoral Scholar PhRMA Foundation - Health Outcomes, Post Doctoral Fellowship Project title: Predictors of Absconding from State Psychiatric Hospitals Study period: 3/1/07 to 2/28/09 XII Scholarly service 2002-present Peer reviewer and contributor to the Royal College of Nursing Journal present Peer reviewer for International Society of Pharmacoepidemiology conference (abstracts) present Peer reviewer to the Journal of Antimicrobial Chemotherapy Peer reviewer to the Chief Scientists Office, Department of Health, Scottish Executive present Peer reviewer to Journal of Managed Care Pharmacy present Peer reviewer to Research in Social and Administrative Pharmacy present Peer reviewer to Annals of Internal Medicine Reviewer and advisor to National Education Scotland Distance Learning Program What is Pharmaceutical Public Health? Project manager: Ailsa Power, Assistant Director NES (Pharmacy), Glasgow, UK.

294 XIII Administrative Activity/Committees Faculty advisor to the Student National Pharmaceutical Association Assessment sub-committee, College of Pharmacy, U of K Academic Committee, International Society for Pharmacoepidemiology Graduate Education and Research Committee (1 year term) XIV Professional Activity Ontario College of Pharmacists International Society for Pharmacoepidemiology Canadian Society of Epidemiology and Biostatistics Society for Epidemiologic Research American Public Health Association Academy of Managed Care Pharmacy American College of Clinical Phramcy International Society for Pharmacoeconomics and Outcomes Research XV Advisory or supervisory activity 2008 Capstone advisory committee for Miriam Azuoru, MPH candidate, College of Public Health Advisory activity on UK pharmacy resident projects Co-supervision of at least one student project as part of the Lothian preregistration pharmacy student training programme at the Western General Hospital, Edinburgh.

295 Updated December 10, 2007 Curriculum Vitae Robert H. McKnight, MPH, ScD Professor, Regular Title Series Department of Preventive Medicine and Environmental Health University of Kentucky College of Public Health Education: Harvard University, Cambridge, Massachusetts Graduate School of Education: Management Development Program in Higher Education Certificate, summer 2000 Johns Hopkins University, Baltimore, Maryland School of Hygiene and Public Health: Doctor of Science, 1984; Master of Public Health, 1980 University of Alabama at Birmingham: Master of Science in Nursing, 1975; Bachelor of Science in Nursing, 1974 Current Appointments: Note: In May 2004, the Department of Preventive Medicine and Environmental Health and its faculty moved from the College of Medicine to the new College of Public Health University of Kentucky, Department of Preventive Medicine and Environmental Health, since 1990 Professor (with tenure), 2006 present Associate Professor (with tenure), Assistant Professor, Joint Appointments: Department of Health Behavior, College of Public Health, 2004 present Department of Epidemiology, College of Public Health, 2004 present Department of Family and Community Medicine, College of Medicine, 2004 present Director, Southeast Center for Agricultural Health and Injury Prevention, 1992 present

296 Robert H. McKnight, MPH, ScD Page 2/32 Past Appointments: Military: Director, HRSA-funded Kentucky Farmworker Health Primary Care Program in Department of Preventive Medicine, University of Alaska-Anchorage, College of Nursing and Health Sciences, Assistant Professor, Interim Director, School of Health Sciences, University of Alaska- Anchorage, University of Alabama-Birmingham, School of Nursing, Assistant Professor, Instructor, University of Alabama Hospital, Birmingham, Alabama Critical Care Nurse, Captain (O-3), US Army Reserve, 1984 th US Army Hospital, Ft. Richardson, Alaska ( ) Honors & Awards: Delta Omega, the Public Health Honor Society, 2006 present Recent Professional Development: University of Kentucky Commonwealth Collaborative Award for Outstanding Service and Community Engagement, 2007 University of Kentucky Wethington Award for Excellence in Research Funding Productivity, May 2004, May 2006 Designated one of the College of Medicine s Research Champions in 1997 for success in extramural funding (ranked 14 th among all faculty) Responding to Conflict: Strategies for Improved Communication AMA Workshop, San Diego, CA, August 2002 Strategic Planning AMA Workshop, Scottsdale, AZ, March 2000 Chairing the Academic Department American Council on Education, February 2000 Leadership Development Course Center for Creative Leadership, Colorado Springs, CO, September/October 1998 (6-day certificate program) The New England Epidemiology Institute Tufts University, Medford, MA, June 1988 (5-day certificate program) Executive Leadership Development for Medical Professionals University of Kentucky College of Business and Economics, February 1998 (5-day certificate program) The Looking Glass Personal Development Course Center for Creative Leadership, Greensboro, NC, August 1997 (5-day certificate program)

297 Robert H. McKnight, MPH, ScD Page 3/32 Current Annual Extramural Funding as Principal Investigator: $1,127,435 for FY 08 for four active projects $5,422,186 for entire life of these four active projects 1. PI: Robert McKnight, MPH, ScD Title: Cooperative Agreement Program for Centers for Agricultural Research, Education, and Disease and Injury Prevention, Award #2 U50 OH Agency: National Institute for Occupational Safety and Health (NIOSH)/Centers for Disease Control and Prevention Funding: $934,867 in FY2008 ($4,272,672 total for five years) Length: September 30, 2006 to September 29, 2011 (4th cycle) Description: Provides core funding for the Southeast Center for Agricultural Health and Injury Prevention. Funds five research, prevention and education projects. 2. PI: Robert McKnight, MPH, ScD Title: Tractor Safety R-25 for Social Marketing and Cost Analysis Agency: CDC/NIOSH Award # 1 R25 OH via Subcontract from Colorado State University Funding: $72,420 in FY 2008 ($139,419 total for two years) Length: September 1, 2005 to December 31, 2007 Description: Supports two new projects that support the National Agricultural Tractor Safety Initiative: 1) social marketing; 2) cost analysis 3. PI: Robert McKnight, MPH, ScD Title: Agricultural Safety and Health Training for Public Health Graduate Students, Award #1 T01 OH Agency: National Institute for Occupational Safety and Health (NIOSH)/Centers for Disease Control and Prevention Funding: $60,148 in FY2008 ($300,740 total for five years) Length: July 1, 2006 to June 30, 2011 Description: This five-year curriculum project expands the current Health of Agricultural Populations curriculum grant into a NIOSH Training Project Grant. It provides scholarships and stipends to MPH, PhD and DrPH students who focus in agricultural health and injury issues. 4. PI: Robert McKnight, MPH, ScD Title: Hispanic Outreach for the Kentucky Children s Health Insurance Program Agency: Kentucky Dept. for Medicaid Services Funding: $60,000 in FY 2008 ($709,355 across nine years) Length: November 1, 1999 to June 30, 2008 Description: Provides outreach and referral targeted to Spanish-speaking Kentuckians to enroll their children in the Children s Health Insurance Program (CHIP)

298 Robert H. McKnight, MPH, ScD Page 4/32 Activities In Other Grants: 1. Mental Healthiness Aging Initiative, A Community Mental Health Aging Educational- Intervention Program Role: Member of Expert Panel PI: Faika Zanjani, PhD and Deborah Murray, EdD Source: USDA Funding: $322,205 Duration: 1 Year Description: Assist elders to lead more healthy and active lives through extensionbased educational interventions. Application Recently Submitted but not Funded: Developing a Social Marketing Strategy for NAGCAT Dissemination Submitted June 2, 2006 to U.S. Department of Agriculture Role: Co-Principal Investigator (Linda Alexander, EdD, Principal Investigator) Funds Requested: Approx. $120,000 across three years This project would have developed and tested a social market program for the prevention of children s agricultural injuries in Kentucky. Worksite Integration for Safety and Health Submitted September 2005, in response to NIOSH RFA OH on Centers for Excellence to Promote a Healthier Workforce Role = Deputy Principal Investigator (P.I.: Richard Clayton, PhD) Funds Requested: $5,723,836 across five years This project would have created a new trans-disciplinary Center at the University of Kentucky to facilitate the integration of occupational health and health education at the worksite. College Assistance Migrant Program Submitted March 14, 2005 to U.S. Department of Education, Office of Migrant Education Role: Principal Investigator Funds Requested: Approx. $467,000 across five years This project would have created a scholarship program at the University of Kentucky and Lexington Community College for 25 dependents of migrant or seasonal farmworkers.

299 Robert H. McKnight, MPH, ScD Page 5/32 Previous Grants and Contracts (completed): Total funds received for the following completed projects: $15,410,536 PI: Robert McKnight, MPH, ScD Title: Cooperative Agreement Program for Centers for Agricultural Research, Education, and Disease and Injury Prevention Source: CDC/NIOSH Years: September 30, 2001 to September 29, 2007 Amount: $3,956,845 (across five years) Description: Provided core funding for the Southeast Center for Agricultural Health and Injury Prevention. Funded five research, prevention and education projects. PI: Robert McKnight, MPH, ScD Title: Supplement to Southeast Center for Agricultural Health and Injury Prevention Source: CDC/NIOSH Years: September 30, 2005 to September 29, 2007 Amount: $72,400 in FY 2007 (one year only) (1 year No Cost Extension) Description: Expanded the Center s Research to Practice focus by developing an initiative on farm tractor safety for high school students PI: Robert McKnight, MPH, ScD Title: Supplement to Southeast Center for Agricultural Health and Injury Prevention Source: CDC/NIOSH Years: September 13, 2006 to September 29, 2007 Amount: $8,820 in FY 2007 Description: Provided travel and clerical assistance for special NIOSH Town Hall meeting in Jackson, Mississippi PI: Robert McKnight, MPH, ScD Title: Coalitions to Improve Health Access by Hispanics in Rural Kentucky and Tennessee Source: USDA Years: September 1, 2001 to December 31, 2006 Amount: $538,373 (across five years) Description: Provided improved healthcare access for Spanish-speaking immigrants by building coalitions from local resources in two rural Kentucky counties and two rural Tennessee counties. PI: Title: Source: Robert McKnight, MPH, ScD Kentucky Migrant Vocational Rehabilitation Outreach Kentucky Dept. of Vocational Education, via U.S. Dept. of Education/Rehabilitation Services Administration Years: October 1, 2000 to December 31, 2005 Amount: $818,510 (across five years)

300 Robert H. McKnight, MPH, ScD Page 6/32 Description: Provided outreach and coordination to link migrant farmworkers with vocational rehabilitation services PI: Robert McKnight, MPH, ScD Title: Kentucky Farmworker Health Program Source: DHHS/HRSA Years: January 1, 1998 to June 30, 2001 Amount: $1,038,087 (across four years) Description: Four-year clinical services program for primary medical, dental, and pharmacy service for migrant and seasonal farmworkers PI: Robert McKnight, MPH, ScD Title: Texas Initiatives for Women s & Children s Health and Safety on Farms Source: University of Texas Health Sciences Center at Tyler Years: October 1, 1999 to September 30, 2000 Amount: $15,000 Description: Consultation to assist a project at the Southwest Center for Agricultural Health, Injury Prevention and Education PI: Robert McKnight, MPH, ScD Title: Farm Family Health and Hazard Surveillance Project Source: CDC/NIOSH Years: September 28, 1990 to September 27, 1998 Amount: $2,844,585 Description: Surveillance of agricultural injuries in a sample of 4,000 Kentucky farm residents PI: Robert McKnight, MPH, ScD Title: Empowering Farm Women to Reduce Hazards to Family Health and Safety on the Farm Source: W.K. Kellogg Foundation Years: September 1, 1992 to December 31, 1997 Amount: $552,259 (across five years) Description: Developed the Kentucky Partnership for Farm Family Safety and Health, a grassroots community coalition of farm women in Bowling Green, Kentucky, which addresses prevention, first-aid, and advocacy for safe and healthy farms. This organization is now a nonprofit agency. PI: Robert McKnight, MPH, ScD Title: Dissemination Phase of Empowering Farm Women to Reduce Hazards to Family Health and Safety on the Farm Source: W.K. Kellogg Foundation Years: June 1, 1996 to May 31, 2000 Amount: $50,000 Description: Dissemination of lessons learned in a five-year farm health/safety demonstration project in Kentucky via publication PI: Robert McKnight, MPH, ScD

301 Robert H. McKnight, MPH, ScD Page 7/32 Title: Southeast Center for Agricultural Health and Injury Prevention (2nd five-year cycle) Source: CDC/NIOSH Years: September 30, 1997 to September 29, 2002 Amount: $3,228,494 Description: Multi-project center to advance research, education and practice for occupational safety and health in agriculture PI: Robert McKnight, MPH, ScD Title: Southeast Center for Agricultural Health and Injury Prevention (1st five-year cycle) Source: CDC/NIOSH Years: September 30, 1992 to September 29, 1997 Amount: $2,244,883 Description: Multi-project center to advance research, education and practice for occupational safety and health in agriculture PI: Robert McKnight, MPH, ScD Title: Training Module for Agricultural Health and Safety Source: CDC/NIOSH Years: July 29, 1993 to June 30, 1994 Amount: $17,280 Description: Produce agricultural health curriculum materials PI: Robert McKnight, MPH, ScD Title: Migrant Farmworker Supplement Source: Lexington Fayette County (KY) Health Department Years: April 1, 2000 to March 31, 2001 Amount: $25,000 Description: Funds to pay for dental, pharmacy, and primary care medical of migrant and seasonal farmworkers Proposals Submitted as Principal Investigator, but not Funded: 2005 Kentucky College Assistance Migrant Program Submitted to U.S. Department of Education $467,000 requested across five years 2000 Kentucky Farmworker Health Program (2 nd three-year cycle) Submitted to DHHS/HRSA 1995 Surveillance of Occupational Pesticide Poisoning Submitted to NIH 1991 Attitudes and Beliefs that Influence Use of ROPS on Farm Tractors Submitted to Equipment Manufacturers Institute 1990 Urgent Psychosocial Care After Rural Pediatric Injury

302 Robert H. McKnight, MPH, ScD Page 8/32 Submitted to National Institute of Mental Health 1990 Primary Prevention of Head Injuries Publications: Submitted to University of Alabama Birmingham McKnight, R.H., Teaster P., Watkins J., Lawrence S. Occupational choice and vulnerability in late life: An example of women in the U.S. International Congress Series, 2005, 1280: McKnight, R.H., Spiller, H. Green Tobacco Sickness in Children and Adolescents, Public Health Reports, 2005, 120: Bryden, P., McKnight, R.H., Weastneat, S. Using U.S. Poison Control Center Records to Identify Bystander Pesticide Exposures. Journal of Agricultural Safety and Health (JASH), 2005, 11(2): Frank, A.L., McKnight, R., Kirkhorn, S., Gunderson, P. Issues of agricultural safety and health. Annual Review of Public Health : Annual Reviews Inc. McKnight R., Spiller H., Westneat, S. & Hopenhayn C. Multi-center electronic data sharing: A 5-state pilot study. Journal of Toxicology Clinical Toxicology, 2002; 40(5): 601. Bryden, P., McKnight R., Spiller H. Pediatric nicotine exposures from ingestion of spittoon contents. Journal of Toxicology Clinical Toxicology, 2001; 39(5): 524. Kidd P., Townley K., Cole H., McKnight R., and Piercy L. The process of chore teaching: Implications for farm youth injury. In J.G. Sebastian & A. Bushy (Eds), Special Populations in the Community: Advances in Reducing Health Disparities (Chapter 10, pp ). Gaithersburg, MD: Aspen Publishers, Inc., Browning S.R., Westneat S.C., Truszczynska H., Reed D.B., McKnight R.H. Farm tractor safety in Kentucky, Public Health Reports, Jan/Feb 1999; 114: Jones M.S., Luchok K.J., McKnight R.H. Empowering farm women to reduce hazards to family health and safety on the farm. Journal of Agromedicine, 1998, 5(2): Browning S.R., Truszczynska H., Reed D.B., McKnight R.H. Agricultural injuries among older Kentucky farmers: The Farm Family Health and Hazard Surveillance Study. American Journal of Industrial Medicine, 1998; 33: Kidd P., Townley K., Cole H., McKnight R., and Piercy L. The process of chore teaching: Implications for farm youth injury. Family and Community Health, 1997, 19(4): McKnight R., Kryscio R., & Koetke C. Temporal clustering of a unique pediatric poisoning: ingestion of tobacco spit from household spittoons. American Journal of Epidemiology (Supplement), 1997; 145(11): S75. Zwerling C., Burmeister L., Reynolds S., McKnight R., Browning S., Reed D., Wilkins J., Bean T., Mitchell L., Hallman E., May J., Stark A. & Hwang S. Use of rollover protective structures Iowa, Kentucky, New York, and Ohio, MMWR, September 12, 1997, 46(36): Reprinted in JAMA, October 8, 1997; 278(14):

303 Robert H. McKnight, MPH, ScD Page 9/32 McKnight R.H., Dawson S.K., Westneat S.C. Delay among the general public in telephoning a poison center. Veterinary and Human Toxicology, 1996; 38(2): McKnight R.H., Dawson S.K., Westneat S.C. Seat belt use in Kentucky: A comparison of five measures. Journal of the Kentucky Medical Association, 1996; 94: Publications (continued): McKnight R.H., Kryscio R.J., Mays J.R., & Rodgers G.C. Jr. Spatial and temporal clustering of an occupational poisoning: The example of Green Tobacco Sickness. Statistics in Medicine, 1996, 15: McKnight R.H., Koetke C.A., Donnelly C. Familial clusters of green tobacco sickness. Journal of Agromedicine, 1996; 3(2): McKnight R.H., Donnelly C., Cole H.P., Ross I.J., Piercy L.R. Collaborating with a medical school to assess health and safety content in an agricultural engineering curriculum. Journal of Engineering Education, 1996; 85(4): McKnight R.H., Piercy L.R., Townley K.F., Kidd P.S., Cole H.P. Parents concern for children s farm safety. Texas Journal of Rural Health, 1995; 14: McKnight R.H., Koetke C.A., Mays J.R. Smokeless tobacco use among adults in Kentucky. Journal of Kentucky Medical Association. 1995; 93: McKnight R.H., Struttmann T.W. & Mays, J.R. Finding homes without smoke detectors: One step in planning prevention programs. Journal of Burn Care & Rehabilitation, 1995, 16: McKnight R.H., Prather T.G., Jones P.H., McLymore R.L., Hetzel G.H. Educational resources for agricultural health and safety: Products of NIOSH-funded efforts in four Southeastern states. Journal of Agromedicine. 1995; 2(2): McKnight R.H., Rodgers G.C., Jr. Occupational tobacco dermatitis reported to a regional poison center. Contact Dermatitis, 1995; 32: 122. Townley K.F., McKnight R.H. Developmentally inappropriate play areas in rural day care: Is it safe to play outdoors? Pediatrics, 1994; 94 (Suppl. Part 2): Reed D.B., McKnight R.H., Horstman S.W. Farming after an amputation: Rehabilitation, adaptation, and unmet needs. Annals of Agricultural & Environmental Medicine, 1994; 1 (2): 228. Ross M.P., Revolinski D., Taurman L., Rodgers G.C. Jr., McKnight R.H. & Levine E.J. Detection of a pediatric occupational poisoning in Kentucky. Veterinary & Human Toxicology, 1994, 36(4): 360. McKnight R.H., Levine E.J., Rodgers G.C., Jr. Detection of green tobacco sickness by a regional poison center. Veterinary and Human Toxicology. 1994; 36(6): Struttmann T.W., Pollack S.H., Spurlock C. Browning S.R., McKnight R.H. Farm tractor-related fatalities Kentucky, MMWR, 1995; 44(26):

304 Robert H. McKnight, MPH, ScD Page 10/32 McKnight R.H. & Hetzel G.H. Trends in farm machinery fatalities. Agricultural Engineering, 1985, 55(5): Publications Submitted: Browning, S.R., Westneat, S.C., McKnight, R.H., Christian A. Suicides among farmers in three southeastern states. Journal of Agricultural Safety and Health, Manuscripts in Progress: Blackburn, J., McKnight, R.H., Brumby S. Clinical Health Indicators in a Cohort of Australian Farmers; manuscript in preparation for submission in February 2008 to Journal of Agromedicine. McKnight, R.H., Myers, M., Donovan T. A History of Agricultural Health and Safety in the United States; manuscript in preparation for submission in early 2008 to either Journal of Agromedicine or Journal of Agricultural Safety and Health. Abstracts Published in Conference Proceedings: Bryden, P., McKnight, R., & Westneat, S. Poison center surveillance of bystander pesticide exposures. In Abstracts, 5 th International Symposium on the Future of Rural Peoples, Saskatoon, Canada, October 19-23, 2003; p. T-40. McKnight R.H. Curriculum development for agricultural occupational health: The Kentucky experience. In: Abstracts, 6th International Conference Scientific Committee on Education and Training in Occupational Health, ICOH: Best Practices in Occupational Safety and Health, Education, Training, and Communication: Ideas That Sizzle, Baltimore, MD; October 28 30, 2002; p. 86. McKnight R.H., Hopenhayn C., Westneat, S., Bryden, P. Are occupational pesticide exposures of workers age > 55 underestimated by US Poison Control Centers? In: Abstracts, 4th Conference on Aging and Work: Promotion of Work Ability and Employability, Krakow, Poland; June 12 15, 2002, p. 55. McKnight R.H., Burlingham B. Threats to job security and lifestyle among U.S. tobacco farmers: Conceptual issues and mental health consequences. In: Abstracts, International Research Conference: Health Hazards and Challenges in the New Working Life, Stockholm, Sweden; January 11 13, 1999; p. 11. McKnight R.H., Rao P.A.. Migration of farm labor in the US: Overcoming constraints to planning health care. In: Abstracts, International Research Conference: Health Hazards and Challenges in the New Working Life, Stockholm, Sweden; January 11 13, 1999; p. 11. Reed D.B., McKnight R.H., Browning S.B., Westneat S.C. Farmers who never quit working: Self-reported health conditions in an aging workforce. In Book of Abstracts, 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , 1998; p. 20.

305 Robert H. McKnight, MPH, ScD Page 11/32 McKnight R.H., Reed D.B., Westneat S.C. Work activities and physical limitations of farmers age 80 in Kentucky, USA. In Book of Abstracts, 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , 1998; p. 21. McKnight R.H., Reed D.B., Westneat S.C. Using multi-mode methodologies to study the older worker: Lessons learned from the Kentucky older farmers study. In Book of Abstracts, 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , 1998; p. 32. McKnight R.H. Pediatric ingestion of tobacco spit: The hazard of household spittoons. In Book of Abstracts, 4th World Conference on Injury Control, Amsterdam, The Netherlands, May 17 20, 1998; p Abstracts Published in Conference Proceedings (continued): McKnight R.H., Jones M.S. Lessons learned from a women-focused partnership for farm safety. In Book of Abstracts, 4th World Conference on Injury Control, Amsterdam, The Netherlands; May 17 20, 1998; p McKnight R.H. Activities at the Southeast Center for Agricultural Health and Injury Prevention. In NIOSH, Agricultural Health & Safety Conference: Program Abstracts Morgantown, WV; July 15 17, 1997; p. 7. McKnight R.H., Reed D.B., Browning S.R. From the phone to the fields: The Kentucky Farm Family Health and Hazard Surveillance Project. In NIOSH, Agricultural Health & Safety Conference: Program Abstracts, Morgantown, WV; July 15 17, 1997; p. 24. Browning S.R., Reed D.B., McKnight R.H. Back pain in older Kentucky farmers. In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California; Oct. 29- Nov. 2, 1995; p. 22. Levine E.J., McKnight R.H., Rodgers G.C. Jr. Follow-up of occupational poisonings reported to a regional poison center: Findings, advantages, and limitations. In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29 Nov. 2, 1995, p Luchok K.J., McKnight R.H. Women's views on preventing work-related injury and disease in a male-dominated workforce: An example from farming. In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29-Nov. 2, 1995; p. 93. McKnight R.H., Reed D.B., Browning S.R. Are children working on their family's farm protected by roll-over protection on tractors? In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29-Nov. 2, 1995; p Reed D.B., Browning S.R., McKnight R.H. Hearing loss among older farmers: An occupational risk. In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California; Oct. 29-Nov. 2, 1995, p Stea J.B., McKnight R.H. Preventing suicides by jail inmates: Why a new paradigm for public health action is needed. In Abstracts, American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29-Nov. 2, 1995; p. 415.

306 Robert H. McKnight, MPH, ScD Page 12/32 Moore K.C., Cole H.P., McKnight R.H., Piercy L.R. Promoting safety behaviors through stories, simulations, and reflection. In Proceedings of the Human Factors and Ergonomics Society 38th Annual Meeting. Nashville, Tennessee; October 24-28, 1994; p McKnight R.H., Mays J.R., Rodgers G.C. Jr. Poison control centers and agricultural health: Missed opportunities for surveillance and prevention? In NIOSH/CDC, Abstracts, Agricultural Safety and Health: A National Conference on Detection, Prevention & Intervention. Columbus, Ohio; August 24-26, 1994; p. 9. McKnight R.H., Janney C.A. Hazard surveillance of farms lacking rollover protective structures (ROPS) on farm tractors. In NIOSH/CDC, Abstracts, Agricultural Safety and Health: A National Conference on Detection, Prevention & Intervention. Columbus, Ohio; August 24-26, 1994; p. 40. Zollicoffer A.M., Cole H.P., McKnight R.H., Piercy L.R., Ross I.J. Saliency of occupational safety and health in a department of agricultural engineering. In: NIOSH/CDC, Abstracts, Agricultural Safety and Health: A National Conference on Detection, Prevention & Intervention. Columbus, Ohio; August 24-26, 1994; p.10. Abstracts Published in Conference Proceedings (continued): Cole H.P., McKnight R.H., Piercy L.R., Preventing injuries through interactive stories. In: NIOSH/CDC, Abstracts, Agricultural Safety and Health: A National Conference on Detection, Prevention & Intervention. Columbus, Ohio; August 24-26, 1994; p. 62. Arcury T., McKnight R., Turner W., & Shaw P. Qualitative methods to assess the health and safety concerns of African American farmers. In Abstracts of Poster Presentations, First National Conference for NIOSH-Sponsored Centers for Agricultural Disease and Injury Research, Education, and Prevention, Univ. of California, Davis, Feb. 27 Mar. 1, 1994; p.25. Cole H., McLymore R.L., McKnight R.H., Piercy L.R. Stories to live by: Narrative simulation exercises for preventing agricultural injuries. In Abstracts of Poster Presentations, National Conference for NIOSH-Sponsored Centers for Agricultural Disease and Injury Research, Education & Prevention, Univ. of California, Davis, Feb. 27 Mar. 1, 1994; p. 9. Reed D. & McKnight R. Development and refinement of on-farm physical screenings for older farmers. In Abstracts, NIOSH Symposium on Occupational Efforts to Prevent Injury and Disease in Agricultural Workers, Lexington, KY, August 1993 ; pp Arcury T., Shaw P., Turner W., McKnight R. & Enochs R. Assessing the health and injury concerns of African American farmers: The first steps. In Abstracts, NIOSH Symposium on Occupational Efforts to Prevent Injury and Disease in Agricultural Workers, Lexington, KY, August 1993; pp McKnight R.H., Spurlock C.W., & Myers J.R. Agricultural injury surveillance in Kentucky: An example of university, state, and federal cooperation that works. In Abstracts, 2nd World Conference on Injury Control, Centers for Disease Control, Atlanta, GA, May 1993; pp McKnight R.H. & Reed D.B. Changes in public opinion toward automotive airbags since 1990: Is the diffusion model working? In Abstracts, 2nd World Conference on Injury Control, Centers for Disease Control, Atlanta, GA, May 1993; p McKnight R.H. & Wolf J.G. An annual statewide survey of injury control issues and injury hazards: Will it work for you? In Abstracts, 2nd World Conference on Injury Control, Centers for Disease Control, Atlanta, GA, May 1993; pp

307 Robert H. McKnight, MPH, ScD Page 13/32 Kidd P., Townley K., McKnight R.H. University-based collaborative efforts to prevent childhood agricultural injuries. In Abstracts, 2nd World Conference on Injury Control, Centers for Disease Control, Atlanta, GA, May 1993; p McCulloch B.J., McKnight R.H., Auslander M., Kidd P.S. & Landen D. Preventing injury and disease in the rural elderly. The Gerontologist, October 1992, 32 (special issue II): 107. McKnight R.H., Kidd P.S., Focus group interviews: An innovative method for behavioral risk factor surveillance in agriculture. In Abstracts, Third International Symposium: Issues in Health, Safety, and Agriculture, Saskatoon, Saskatchewan; May 10 15, 1992, p McKnight R.H., Reed D.B., Barriers to accessing emergency medical services on farms: What number to dial? In Abstracts, Third International Symposium: Issues in Health, Safety, and Agriculture, Saskatoon, Saskatchewan; May 10 15, 1992, p. 79. McKnight R.H., Horstman S.W., Piercy L.R., Early K.L. Video hazard monitoring: A new technique of farm surveillance. In Abstracts, Third International Symposium: Issues in Health, Safety, and Agriculture, Saskatoon, Saskatchewan; May 10 15, 1992, p. 99. Presentations at national & international professional meetings: Bryden, PA, McKnight, RH, Pollack, SH. Adolescent Pesticide Exposures. Presented at the American Public Health Association 135 th Annual Meeting, Washington, D.C., November 6, Bryden PA, McKnight, RH, Spiller,HA, Westneat, SC. The Narrative Section of Poison Control Center Records: Advantages and Disadvantages to Identifying Agricultural Poisonings. Presented at the United States Environmental Protection Agency Office of Pesticide Programs Pesticide Worker Safety and Health Conference, Arlington, Virginia, October 3, Anyaegbunam, C., McKnight, R. Designing Community-Based Social Marketing Programs for Tractor Safety: Formative Research Findings. Presented at the National Agricultural Tractor Safety Initiative Meeting, Marshfield, WI, July 30-31, Anyaegbunam, C., McKnight, R., Donovan, T. Overcoming Barriers to Safe Operation of Agricultural Tractors: Insights from Participatory Community-Based Social Marketing. Paper presented at the 2007 Annual Conference of the National Institute for Farm Safety. Penticton, British Columbia, June 24-28, Chamness, J., McKnight, R. Linking a Health Department with a College of Public Health: A Recipe for Success in Addressing Rural Hispanic Populations. 13 th Annual National Rural Health Association Minority and Multicultural Conference, Anchorage, Alaska, May 15, McKnight, R., Myers, M. Agricultural safety and health in the U.S., Paper presented at the Third International Conference on the History of Occupational and Environmental Health, sponsored by the International Commission on Occupational Health (ICOH) and the Centre for the History of Medicine in the University of Birmingham School of Medicine; Dudley, West Midlands, United Kingdom, April 18-21, Anyaegbunam, C., Cole, H., McKnight, R. Misconceptions About Aging Farmers and Their Community Economic, Social and Cultural: Implications for Farm Safety and Health.

308 Robert H. McKnight, MPH, ScD Page 14/32 University of Illinois-sponsored USDA Conference on Aging Farmers Health and Safety, Indianapolis, Indiana, March 7, McKnight, R., Crystal, R. & Cinnamon, K. Outcomes of a Five-Year Project to Connect Disabled Farm Workers to Vocational Rehabilitation Services in the United States, 28 th International Congress of Occupational Health, Milan, Italy, June 15, McKnight, R., Teaster, P. & Watkins, J. Quality of Life in Retirement Among US Women Known as the Government Girls of World War II, 28 th International Congress of Occupational Health, Milan, Italy, June 14, McKnight, R., Chamness, J., & Spradling, P. Policy Implications for Leadership When Planning a Safe Community Application, 15 th International Safe Communities Conference, Cape Town, South Africa, April 11, Bryden, P., McKnight, R. Improving Agricultural Pesticide Poisoning Surveillance in the U.S., 8 th World Congress on Injury Prevention and Safety Promotion, Durban, South Africa, April 5, Presentations at national & international professional meetings (continued): McKnight, R., Chamness, J. Developing an Academic-Community Partnership to Promote a Safe Community Application from the United States, World Congress on Injury Prevention and Safety Promotion, Durban, South Africa, April 4, McKnight, R., Anyaegbunam, C. Promoting Farm Tractor Safety in the United States Through Social Marketing, World Congress on Injury Prevention and Safety Promotion, Durban, South Africa, April 4, McKnight, R. Lessons Learned as a Writer and Reviewer of Grants, Presented at NIOSH/NORA Town Hall Meeting, Jackson, Mississippi, March 24, McKnight, R., Anyaegbunam, C., Cole, H. Social Marketing to Promote Farm Tractor Safety in the United States, 14 th International Conference on Safe Communities, Bergen, Norway, June 14, McKnight, R., Bryden, P., Westneat, S. Agricultural Pesticide Poisonings in the Southeast United States, Nordic Meeting on Agricultural Occupational Health, 2004, Stockholm, Sweden November 29 December 1, McKnight, R., Browning, S., Westneat, S. Suicide Among Older Farmers in Kentucky, USA: , 2 nd International Conference on Work Ability, Verona, Italy, October 18-20, McKnight, R., Teaster, P. Choice of Occupation as a Factor in Late Life Vulnerability: An Example from the USA, 2 nd International Conference on Work Ability, Verona, Italy, October 18-20, Rennekamp, R., Riddle, B., McKnight, R., Clarke, B., and Broadwater, G. Improving Health Access for Rural Hispanic Populations. Paper presented at the First Conference on Working with Latinos/Hispanics in the U.S.A., University of Puerto Rico, San Juan, PR, October 27-29, 2004.

309 Robert H. McKnight, MPH, ScD Page 15/32 McKnight, R. Promoting Safe Agricultural Communities: Activities of the North American Agromedicine Consortium, 13 th International Conference on Safe Communities, Prague, Czech Republic, May 31-June 3, Rennekamp, R., McKnight, R. H. Improving Health Access for Rural Hispanic Populations, USDA Children, Youth, and Families at Risk Conference (CYAFR), Seattle, Washington, May 11-14, Bryden, P., McKnight, R., & Westneat, S. Poison Center Surveillance of Bystander Pesticide Exposures, 5 th International Symposium on the Future of Rural Peoples, Saskatoon, Canada, October 19-23, McKnight, R.H. Coalition Development to Increase Health Access Among Immigrant Farm Workers, Nordic Meeting on Agricultural Occupational Health and Safety, Kongsberg, Norway, August 25-27, McKnight R.H., Clarke B., Tanner B., Belendez Z., Broadwater G., Rennekamp R., McCoy J. Developing Latino Health Coalitions to Improve Access to Health Care: Innovations, Frustrations, and Successes After One Year, 2003 Priester Extension Health Conference, Phoenix, Arizona, April 22-24, Presentations at national & international professional meetings (continued): McKnight R.H., Reed, D. Issues of Aging Among Agricultural Populations North American Agromedicine Consortium, 15 th Annual Meeting, San Diego, CA, November 17-19, McKnight R.H., Bryden P., Westneat, S. Validity Of Occupational Versus Non-Occupational Classification Of Pesticide Exposures. North American Agromedicine Consortium, 15 th Annual Meeting, San Diego, CA, November 17-19, Henderson R., Wheat J., McKnight R.H., Pitzer P. Starting and Maintaining Agromedicine Programs. North American Agromedicine Consortium, 15 th Annual Meeting, San Diego, CA, November 17-19, McKnight R.H. Curriculum Development for Agricultural Occupational Health: The Kentucky Experience, 6th International Conference Scientific Committee on Education and Training in Occupational Health, ICOH: Best Practices in Occupational Safety and Health, Education, Training, and Communication: Ideas That Sizzle, Baltimore, MD; October 28 30, McKnight R.H., Spiller H., Westneat, S. & Hopenhayn C. Multi-Center Electronic Data Sharing: A 5-State Pilot Study North American Congress of Clinical Toxicology Annual Meeting, Palm Springs, CA, September 24-29, McKnight R.H., Westneat, S., Bryden, P. Limitations Of Agricultural Pesticide Poisoning Data Collected By U.S. Poison Control Centers, Nordic Meeting on Agricultural Occupational Health, Kuopio, Finland, August 26-28, McKnight R.H., Broadwater G., Tanner B., Clarke B., Belendez Z. Coalitions to Improve Health Access by Hispanics in Rural Kentucky and Tennessee, 2002 International Community

310 Robert H. McKnight, MPH, ScD Page 16/32 Development Society Conference, Cleveland, MS, July 23, 2002 (presented by Gae Broadwater). McKnight R.H. Agricultural Safety Issues in the United States, Invited Lecture to the Faculty of the Department of Engineering and Energetics, Agricultural University of Krakow, Krakow, Poland, June 12, McKnight R.H., Hopenhayn C., Westneat, S., Bryden, P. Are Occupational Pesticide Exposures of Workers Age > 55 Underestimated by US Poison Control Centers?, 4th Conference on Aging and Work: Promotion of Work Ability and Employability, Krakow, Poland, June 12 15, McKnight R.H. Activities at the Southeast Center for Agricultural Health and Injury Prevention, North American Agromedicine Consortium, 14 th Annual Meeting, Charleston, SC, November 4-6, Bryden P., McKnight, R.H., Spiller, H.A. Pediatric Nicotine Exposures From Ingestion Of Spittoon Contents. North American Congress of Clinical Toxicology 2001, Montreal, October 8, McKnight, R.H. Coalition development for agricultural health and safety: Examples from Kentucky USA. Nordic Conference on Agricultural Occupational Health. Horsens, Denmark. September 18, Presentations at national & international professional meetings (continued): McKnight, R.H., Burtt, D.S., Doherty, C.W. Where is the evidence: Do enabling services really boost primary care visits? 2001 National Farmworker Health Conference, San Juan, Puerto Rico, April 26-29, McKnight, R.H. and Martin, R. Lessons learned while starting the first migrant health program in Kentucky. North American Agromedicine Consortium Annual Meeting, Gainesville, FL, Dec. 3-5, McKnight, R. Developing a health care system for migrant agricultural workers in Kentucky, USA. Nordic Meeting on Agricultural Occupational Health, Alnarp, Sweden, September 24-26, McKnight, R., Jones, M.S. Women as change agents for agricultural health and safety: Examples from the United States. Nordic Meeting on Agricultural Occupational Health, Alnarp, Sweden, September 24-26, Cole, H., McKnight, R., Browning, S., Reed D., Struttmann, T., Piercy, L., Westneat, S. Estimates of the probability of death during farm tractor overturns. NIOSH Occupational Injury Symposium, Pittsburgh, PA, Oct. 17, McKnight R., Jones S. Building partnerships to improve the health of farm and agricultural populations. 4 th World Rural Health Conference, Calgary, Alberta, August 18, Rice C., McKnight R., Tanner B. A multi-state model linking cooperative extension and schools of public health. Priester Extension Health Conference, Denver, Col., May 9, 2000.

311 Robert H. McKnight, MPH, ScD Page 17/32 McKnight R., McDonald M., Berardino J. Seeking your input: A research agenda for farmworker health. National Farmworker Health Conference, Portland, OR, May Cameron S., Bauer S., Brandstetler H., Doolen A., McKnight R. Strategies in environmental and occupational health promotion. National Farmworker Health Conference, Portland, OR, May Berardino J., McKnight R., McDonald M. Creating a research agenda for farmworker health. NIOSH Agricultural Health Center Conference, Cooperstown, NY, April McKnight R. NIOSH Centers for Agricultural Health and Injury Prevention (Roundtable discussion). American Public Health Association, Chicago, IL, November 10, McKnight R., Rao P. Migration of farm labor in the US: Overcoming constraints to planning health care. Health Hazards and Challenges in the New Working Life, Stockholm, Sweden, January 12, McKnight R., Harju, B. Burlingham B. Threats to job security and lifestyle among U.S. tobacco farmers: Conceptual issues and mental health consequences. Health Hazards and Challenges in the New Working Life, Stockholm, Sweden, January 11, McKnight R. Agricultural safety and health: Defining research and collaboration. Workshop, 11 th Annual East Coast Migrant Stream Forum, Springfield, Massachusetts; November 13 15, McKnight R. Epidemiologic surveillance. Midwest Farmworker Stream Forum, San Antonio, Texas; November 6 8, Presentations at national & international professional meetings (continued): Browning S., Reed D., McKnight R. Prevalence and risk factors for arthritis among older Kentucky farmers. 4th International Symposium: Rural Health and Safety in a Changing World, Saskatoon, Saskatchewan; October 18 22, Reed D.B., McKnight R.H., Browning S.B., Westneat S.C. Farmers who never quit working: Self-reported health conditions in an aging workforce. 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , McKnight R.H., Reed D.B., Westneat S.C. Work activities and physical limitations of farmers age 80 in Kentucky, USA. 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , McKnight R.H., Reed D.B., Westneat S.C. Using multi-mode methodologies to study the older worker: Lessons learned from the Kentucky older farmers study. 2nd International ICOH Conference on Aging and Work, Elsinore, Denmark; Sept , McKnight R.H. Pediatric ingestion of tobacco spit: The hazard of household spittoons. 4th World Conference on Injury Control, Amsterdam, The Netherlands, May 17 20, McKnight R.H., Jones M.S. Lessons learned from a women-focused partnership for farm safety. 4th World Conference on Injury Control, Amsterdam, The Netherlands; May 17 20, Browning S.R., Westneat S.C., McKnight R.H. Work tasks, days worked, supervision, and risk of farm-related injury among Kentucky farm children. NIOSH Agricultural Health and Safety Conference. Morgantown, West Virginia; July 15 17, 1997.

312 Robert H. McKnight, MPH, ScD Page 18/32 Browning S.R., Westneat S.C., Reed D.B., McKnight R.H., Hazard surveillance among Kentucky farm children: Results from the Farm Family Health and Hazard Surveillance Study. NIOSH Agricultural Health and Safety Conference, Morgantown, WV, July 15 17, Browning S.R., Reed D.B., McKnight R.H. Prevalence and risk factors for arthritis among older Kentucky farmers. Society for Epidemiologic Research. Edmonton, Alberta; June 12 14, McKnight R.H., Kryscio R.J., Koetke C.A. Temporal clustering of a unique pediatric poisoning: ingestion of tobacco spit from household spittoons. 30th Annual Meeting of the Society for Epidemiologic Research, Edmonton, Alberta, June 12 14, Browning S.R., Truszczynska H., Westneat S.C., Koetke C.A., McKnight R.H. Hazard surveillance of farm tractor safety features. American Industrial Hygiene Conference and Exposition, Dallas, Texas; May 17 23, Browning S.R., Westneat S.C., Koetke C.A., Reed D.B., McKnight R.H. Hazardous work and injuries among Kentucky farm children. Prevention 97, Atlanta, GA; March 20 23, McKnight R.H., Westneat S.C. A unique botanical poisoning during farm work: Green tobacco sickness in Kentucky, USA. 25th International Congress on Occupational Health. Stockholm, Sweden; September McKnight R.H. Prevalence of traumatic amputations in older farmers: Results of injury surveillance in Kentucky, USA. 25th International Congress on Occupational Health. Stockholm, Sweden; September McKnight R.H., Truszczynska H. A profile of children who apply pesticides on family farms in Kentucky. International Society for Environmental Epidemiology 8th Annual Conference, Edmonton, Alberta, August Presentations at national & international professional meetings (continued): McKnight R.H., Westneat S.C. The relationship of tobacco plant exposure and moisture to severity of an agricultural poisoning. International Society for Environmental Epidemiology 8th Annual Conference, Edmonton, Alberta, August Cole H.P., McKnight R.H., Rodgers G.C. Training health providers to diagnose, treat, and prevent green tobacco sickness. 25th National Institute for Farm Safety Conference, Ft. Mitchell, Kentucky; June 23-27, McKnight R.H., Westneat S.C., Dawson S.K. Limitations of adverbial frequency descriptors as a response mode in survey questions: What do always, seldom, and never imply? Society for Epidemiological Research, Boston, Massachusetts; June Browning S.R., Truszczynska H., McKnight R.H. Farm work related injuries among older Kentucky farmers. Society for Epidemiological Research, Boston, Massachusetts, June Cole H.P., McKnight R. H., Rodgers G.C. Diagnosis and treatment of an agricultural illness: The role of simulation exercises in health professions continuing education. 3rd Annual NIOSH Agricultural Health and Safety Conference. Iowa City, Iowa; March 24-26, McKnight R.H., Browning S.R., Reed D.B. Survivors of farm tractor overturn: A profile from Kentucky, USA. 3rd International Conference on Injury Prevention and Control, Melbourne, Australia, February 1996.

313 Robert H. McKnight, MPH, ScD Page 19/32 McKnight R.H., Dawson S.K., & Donnelly, C. Appropriateness of frequency descriptors in behavioral risk factor questions: does seldom sometimes mean never? 3rd International Conference on Injury Prevention and Control, Melbourne, Australia, February Reed, D.B., & McKnight R.H. At high risk: Developing a methodology for studying older farmers. 3rd International Conference on Injury Prevention and Control, Melbourne, Australia, February Jones M.S., Luchok K.J., McKnight R.H. A partnership approach empowering women to reduce farm injuries and illnesses. American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29-Nov. 2, McKnight R.H., Browning S.R., Reed D.B. Surveillance of tractors without roll-over protective structures on farms with children. American Public Health Association 123rd Annual Meeting, San Diego, California, Oct. 29-Nov. 2, McKnight R.H., Luchok K.J., Preventing occupational injury and disease in an agricultural community: A model based on empowerment of farm women. 4th International Conference on Safe Communities, Fort McMurray, Alberta, Canada, June 6 8, Myers, J.A., & McKnight R.H. Lessons learned from conducting a process evaluation. 4th International Conference on Safe Communities, Ft. McMurray, Alberta, June 6 8, Casale G., Wallace B., Witzke D., Collins T. & McKnight R.H. Resident physicians' health and life style. Prevention '95, New Orleans, Louisiana, April Cole H.P., McKnight R.H., Piercy L.R., McLymore R.L. Interactive narrative and self-protective behavior from tractor roll-over events. 2nd National Conference for NIOSH-Sponsored Agricultural Health and Safety Centers. Fort Collins, Colorado; March 27-28, Presentations at national & international professional meetings (continued): Zollicoffer A.M., Cole H.P., McKnight R.H., Piercy L.R., Ross I.J. Assessing the importance of safety and health instruction in an agricultural engineering department: A pilot study. 2nd National Conference for NIOSH-Sponsored Agricultural Health and Safety Centers. Fort Collins, Colorado; March 27-28, Luchok K.J., Mays J.R., McKnight R.H. Bridging the gaps for Kentucky's migrant farmworkers: The first steps. 2nd National Conference for NIOSH-Sponsored Agricultural Health and Safety Centers, Fort Collins, Colorado, March 27-28, McKnight R.H., Reed D.B., Browning S.R. Farm children at work: On and off the farm. Rural Child and Adolescent Rural Injury Control Conference, Madison, Wisconsin, March 8 9, Cole H.P., McKnight R.H., Piercy L.R., McLymore R.L. Teaching and assessing youth safety decisions through stories. Child & Adolescent Rural Injury Control Conference. Madison, Wisconsin; March 8-9, McKnight R.H., Kryscio R.J., Mays J., & Rodgers G. Jr. Using a regional poison center to detect poisoning clusters: The example of Green Tobacco Sickness. Conference on Statistics and Computing in Disease Clustering, Vancouver, BC, July 21 22, 1994.

314 Robert H. McKnight, MPH, ScD Page 20/32 Reed D.B., McKnight R.H., Horstman S.W. Farming after an amputation: Rehabilitation, adaptation and unmet needs. XII International Congress of Agricultural Medicine and Rural Health, Stockholm, Sweden, July McKnight R., VonEssen S., & Frumkin H. How to incorporate agricultural health and safety instruction into the health profession curriculum. 17th Annual National Conference on Rural Health, San Francisco, CA, May 25 28, Donham K., McKnight R., & Ivory J. Agricultural medicine a national research program for prevention. 17th Annual National Conference on Rural Health, San Francisco, CA, May 25 28, Arcury T., McKnight R.H., Shaw P. & Turner W. Health and injury concerns of African- American farmers in the southeast. US Society for Applied Anthropology Annual Meeting, Cancun, Quintana Roo, Mexico, April Kidd P., Huddleston S., McKnight R., Townley K., Cole H. & Piercy L. Risk factors for agricultural injury in farm youth. 32nd Biennial Convention of Sigma Theta Tau International, Indianapolis, IN, December Kidd P., Townley K., Huddleston, S., McKnight R., Cole, H. & Piercy, L. Youth perceptions of risk in the farm environment. American Public Health Association convention, San Francisco, CA, October 24 28, Auslander M., Spurlock C., & McKnight R. Excess farm injuries associated with tobacco harvesting. American Public Health Association convention, San Francisco, CA, Oct , McKnight R.H. The Kentucky Farm Family Health and Hazard Surveillance Project. American Public Health Association, San Francisco, CA, October 24 28, Spurlock C., Auslander M., & McKnight R. Injuries: One result of child labor in agriculture. American Public Health Association, San Francisco, CA, October 24 28, Presentations at national & international professional meetings (continued): McKnight R.H., McCulloch B.J., & Reed D.B. Issues in studying the older farmer: Lessons learned from farming. American Public Health Association, Washington, DC, Nov McKnight R.H., Reed D.B. Women on the family farm: Building a research agenda. American Public Health Association 120th Annual Meeting, Washington, DC. November Kidd P.S., McKnight R.H. & Koetke C.A. Focus group interviews for surveillance of occupational health risks in rural workers. Poster presentation at American Public Health Association convention, Washington, DC, November McKnight R.H., Townley K.F. & Auslander, M. Public health strategies to strengthen farm families in Kentucky. World Congress on the Family, Columbus, Ohio, August Townley K.F. & McKnight R.H. Developmentally inappropriate play areas in rural daycare: Is it safe to play outside? CDC International Conference on Child Daycare Health, Atlanta, GA, June 1992.

315 Robert H. McKnight, MPH, ScD Page 21/32 McKnight R.H. & Townley K.F. Are stricter health and safety standards needed for daycare provided on family farms? CDC International Conference on Child Daycare Health, Atlanta, GA, June McKnight R.H. & Spurlock C.W. Prevention-focused surveillance of agricultural injuries. Prevention '92, Baltimore, MD, March McKnight R.H. Is health protection a neglected concept? American Public Health Association, Chicago, IL, October McKnight R.H. & Saylor B.L. Defining core health services in a time of economic crisis. American Public Health Association, Chicago, IL, October McKnight R.H. & Cornwell N. Health planning in a sub-arctic city: The Anchorage experience. American Public Health Association, Boston, MA, November McKnight R.H., Williams T.K. & Schnitzer P.G. Epidemiologic research to reduce injury deaths in Alaska. Louisiana State University Medical Center Conference: Focus on the Future, New Orleans, LA, October McKnight R.H. & Hetzel G.H. Understanding risk assessment from the epidemiologic perspective (Paper # ). American Society of Agricultural Engineers summer meeting, Baltimore, MD, June McKnight R.H. The all-terrain vehicle: Social benefit or injury menace to Alaska natives? American Public Health Association, Las Vegas, Nevada, September Predger B., Kochis K., Bashaw C.L. & McKnight R.H. Strategies to control dog bites by pit-bull terriers. American Public Health Association, Las Vegas, Nevada, September McKnight R.H. & Hetzel G.H. Planning state laws to regulate the all-terrain vehicle. American Rural Health Association, White Haven, PA, September McKnight R.H. & Hetzel G.H. All-terrain vehicle deaths and injuries on US farms. American Society of Agricultural Engineers summer meeting, San Luis Obispo, CA, July McKnight R.H. & Bashaw C.L. Deaths associated with all-terrain vehicles in the 48 contiguous states. American Public Health Association, Washington, DC, November McKnight R.H. & Hetzel G.H. Farm machinery injuries: Epidemiology and rural injury control. American Rural Health Association, Chicago, IL, June Presentations at state & local professional meetings: McKnight R.H. & Hetzel G.H. Annual trends in farm tractor and machinery deaths, (Paper #84-557). American Society of Agricultural Engineers winter meeting, New Orleans, LA, December McKnight R.H. Farm tractor fatalities: National study. American Public Health Association, Anaheim, CA, November McKnight, RH (2004). Tips for Successful Grant Writing presented at Kentucky and Tennessee Latino Health Access Coalition 3 rd Multi-State Annual Conference, Fall Creek Falls State Park, Tennessee, October 27-29, 2004.

316 Robert H. McKnight, MPH, ScD Page 22/32 McKnight, RH (2004). Lunch seminar/discussion on Agricultural Health with Rural Medical Scholars Program students, University of Alabama, Tuscaloosa, September 10, McKnight, RH (2004). Projects and Activities of the Southeast Center for Agricultural Health and Injury Prevention, Southern Regional Farm Safety Symposium #1, Tennessee Cooperative Extension Service, Nashville, Tennessee May 11, McKnight, RH (2004). Overview of NIOSH Initiatives in Agricultural Health and Safety, Southern Regional Farm Safety Symposium #1, Tennessee Cooperative Extension Service, Tennessee May 10, McKnight, RH (2004). Activities at the Southeast Center for Agricultural Health and Injury Prevention, presented to faculty at Georgia Southern University, Statesboro, Georgia, April 15, McKnight, RH (2004). Finding and Securing Funding for Agricultural Health and Safety, invited seminar, School of Public Health and School of Nursing, Georgia Southern University, Statesboro, Georgia April 15, McKnight, RH (2004). Identifying and Securing Funding to Address Issues Affecting Rural Workers and Industries, Health and Safety Summit sponsored by Mississippi State University Extension Service, Jackson, Mississippi, March 23-24, McKnight R.H. Defining agromedicine. Agromedicine Pre-summit Working Group, State of Mississippi, Jackson, Mississippi, November 7, McKnight R.H. Epidemiology of agricultural chemical poisonings. Midwest Regional Toxicology Symposium, Louisville, November 12, McKnight R.H. The public in planning a voice to be heard. Alaska Public Health Association meeting, April McKnight R.H. The theory behind injury control. Alaska Public Health Association meeting, April McKnight R.H. Forum on public health: Understanding injuries as a public health problem. Alaska-Hawaii Joint Convention of the National Association of Social Workers, Honolulu, Hawaii, March Presentations at state & local professional meetings (continued): McKnight R.H. Injury epidemiology: Applications for safety engineers. Alaska Chapter of American Society of Safety Engineers meeting, Anchorage, Alaska, September McKnight R.H. Trauma as a public health problem. Critical Care Conference, Anchorage, Alaska, October McKnight R.H. The effects of Alaska's child restraint law. Alaska Emergency Medical Services Symposium, Anchorage, Alaska, November McKnight R.H. An overview of injury control. Alaska Emergency Medical Services Symposium, Anchorage, Alaska, November 1985.

317 Robert H. McKnight, MPH, ScD Page 23/32 Middaugh J.P., McKnight R.H. & Halbert S. All-terrain vehicle injuries in Alaska. 6th Annual Governor's Safety and Health Conference, Anchorage, Alaska, October McKnight R.H. Is Alaska's child vehicle occupant restraint law working? 2nd Annual UAA Research Symposium, Anchorage, Alaska, September Service Practice, Service, and Outreach Programs Developed with Extramural Funds: Title: Kentucky Farmworker Health Program Description: 4-year clinical services program for primary medical, dental, and pharmacy care for migrant and seasonal farmworkers. Funded by DHHS/Health Resources and Services Administration. Role: PI, Director, supervisor and leadership for a staff of six Funding: Approximately $250,000 per year; $1,038,087 across four years Comment: This was the first migrant health program in Kentucky, serving a five-county area around and including Lexington, Kentucky. Title: Migrant Network Coalition Description: Grassroots advisory and networking group organized in 1994 Role: Catalyst to start the coalition Funding: Began with $3,000 to $4,000 per year from first five-year cycle of Southeast Center for Agricultural Health award. This coalition was incubated by the Center until it was able to become a nonprofit organization. The coalition is now independent from the Center and sponsors an annual Migrant Network Coalition Conference in Lexington each year. Title: Kentucky Migrant Vocational Rehabilitation Outreach Description: Five-year outreach project to identify migrant farmworkers with disabilities and link them to services of the Kentucky Department of Vocational Rehabilitation for job retraining. One of 14 such programs in the United States. Role: PI, Director and supervisor for a staff of five Funding: U.S. Department of Education/Rehabilitation Services Administration, via subcontract from the Commonwealth of Kentucky. Approximately $160,000 per year ( ); $818,510 total Practice, Service, and Outreach Programs Developed (continued): Title: Hispanic Outreach for Kentucky Children s Health Insurance Program Description: Provides outreach and referral targeted to Spanish-speaking Kentuckians to enroll their children in the Children s Health Insurance Program (CHIP) Role: PI, Director, leadership and supervisor for two staff. Funding: Approximately $60,000-$120,00 per year, each year since 1999 (total of $649,355 over six years)

318 Robert H. McKnight, MPH, ScD Page 24/32 Title: Description: Role: Funding: Coalitions to Improve Health Access by Hispanics in Rural Kentucky and Tennessee Provides improved healthcare access for Spanish-speaking immigrants by building coalitions from local resources in two rural Kentucky counties and two rural Tennessee counties. Funded by USDA Fund for Rural America Project. Director, Principal Investigator Approximately $140,000 per year ($538,373 for five years) Title: Kentucky Partnership for Farm Family Safety and Health Description: Funded from grant entitled Empowering Farm Women to Reduce Hazards to Family Health and Safety on the Farm. Grassroots community coalition of farm women in Bowling Green, Kentucky, who address prevention, first-aid, and advocacy for safe and healthy farms. This organization is now a sustainable nonprofit agency. Role: Principal Investigator Funding: W.K. Kellogg Foundation in 1992 for $552,259 for five years University Committees: Member, College of Agriculture Search Committee for Biosystems and Agricultural Engineering Safety/Health Faculty (2007) UK Representative on statewide University Engagement and Outreach Work Group for the Council on Post-Secondary Education ( ) Member, Scientific Advisory Committee for UK Tracy Farmer Center for the Environment, (2006 present) Member, University Senate, (2005 elected for 3-year term) Chair, Practice and Service Committee, College of Public Health ( ) Search Committee for faculty vacancy, Department of Preventive Medicine ( ) Member, Administrative Council, College of Public Health (2005 present) Co-Chair, Environmental Health Track, Priester USDA Extension Health Conference, (2004) Co-Chair, Practice and Service Committee, College of Public Health (2004) Member, Faculty Council, College of Public Health ( ) Member, Appointment, Promotion, and Tenure Committee, College of Public Health ( ) Self-Study Committee for School of Public Health (2004) University Committees (continued): Chair, Search Committee for DDI Professorship in Health Behavior, School of Public Health (2003) Co-Chair, Service portion of College of Public Health Self-Study (2004) Ad Hoc Committee on Emergency Preparedness Option, School of Public Health (2003) Search Committee for Director of Tracy Farmer Center on Environment (2002) Search Committee for School of Public Health Extension Health Faculty (2001) Advisory Committee, Water Resources Research Institute ( )

319 Robert H. McKnight, MPH, ScD Page 25/32 School of Public Health Research Committee ( ) Advisory Committee, Kentucky Injury Prevention and Research Center (1999 present) Six-year Review Committee for Department of Preventive Medicine (1999) Hispanic Task Force, College of Medicine ( ) Search Committee, Epidemiology faculty, UK Sanders-Brown Center on Aging ( ) School of Public Health Planning Committee ( ) School of Public Health Curriculum Committee ( ) College of Medicine Research Committee ( ) Graduate Basic Science Committee for Self-Study (for LCME), College of Medicine ( ) Search Committee for Director of University of Kentucky Survey Research Center (1994) Robert Wood Johnson ad hoc Curriculum Task Force Committee on Introduction to Medical Practice (1991). Steering Committee, Exploratory Center for Health Risk Reduction in Rural Youth (HRRRY) ( ) Advisory Committee, General Preventive Medicine residency program ( ) Steering Committee, University of Kentucky Health Survey ( ) Professional Activities: National and International: Delegate: to International Standards Organization efforts to establish Aquaculture Standards (one of 5 delegates from the U.S.) Bergen, Norway, October 2007 Officer: President, North American Agromedicine Consortium, November 2002 October 2003 Executive Secretary, North American Agromedicine Consortium, Sept Nov Coordinator: Editorial Board: for the 8 Directors of NIOSH-funded Agricultural Health Centers, October 1996 October 1998 Journal of Agromedicine (2004 present) Journal of Agricultural Safety and Health (2001 present) Professional Activities: National and International (continued): Reviewer: Priester USDA National Health Extension Conference (2005) Journal of Agromedicine (2002 present) Journal of Agricultural Safety and Health (1998 present) American Journal of Industrial Medicine (on occasion)

320 Robert H. McKnight, MPH, ScD Page 26/32 American Journal of Public Health (on occasion) Various Manuscripts for NIOSH (1991 present) Scientific program abstracts, American Public Health Association Convention, Injury Control and EMS section (1990; ) Scientific Session abstracts, Child and Adolescent Rural Injury Control Conference, Madison, WI (1994) Advisory boards: Agricultural Safety and Health Network (ASH-Net), W.K. Kellogg Foundation project ( ) Management Board, Southwest Center for Agricultural Health, Injury Prevention, and Education, University of Texas Health Sciences Center at Tyler ( ) Testimony: Congressional testimony on behalf of the University of Kentucky, US House of Representatives Subcommittee on Labor, Health and Human Services, Education and Related Agencies. Washington, DC, April In Part 8a, Testimony of members of Congress and other individuals and organizations, House Committee on Appropriations, pp Consultant: Expert witness testimony, 2007 Ohio State University (2007) University of Saskatchewan, Institute of Agricultural Rural and Environmental Health, for planning of 6 th International Symposium on Public Health and the Agricultural Rural Ecosystem ( ) Planning Committee for NIOSH Town Hall Meeting, Jackson, Mississippi (January 2006 March 2006) Western District Health Service, Hamilton, Australia (April 2006 present) Colorado State University Agricultural, High Plains Intermountain Center for Agricultural Health (2006) Georgia Southern University Agricultural Health Development ( ) Mississippi State University Agromedicine Program Development ( ) National Institute for Occupational Safety and Health (NIOSH) National Farm Tractor Safety Initiative (2003 present) University of Saskatchewan, Institute of Agricultural Rural and Environmental Health, for planning of 5 th International Symposium, Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities ( ) Utah Agromedicine Work Group (2002) Professional Activities: National and International (continued): University of New Mexico College of Medicine ( ) Southwest Center for Agricultural Health, Tyler, Texas ( ) University of Mississippi, Agromedicine Program (1998)

321 Robert H. McKnight, MPH, ScD Page 27/32 Alcorn State University (Mississippi), Agricultural Youth Injury Prevention Project ( ) Southeastern Louisiana University (Hammond, LA), Women and Children s Agricultural Injury Prevention Project ( ) East Carolina University School of Medicine, Agromedicine program ( ) North Carolina State University, Agricultural Health Promotion System project (1993) University of Tennessee, Agricultural Health Promotion System project (1993) Epidemiological design issues, New Brunswick SODA Dioxin Task Force, Fredericton, New Brunswick, Canada ( ) Division of Safety Research, NIOSH/CDC (1990) University of Alabama-Birmingham Injury Prevention Research Center, for development of prevention component of Comprehensive Head Injury Center (1990) Grants Reviewer: NIH Center for Scientific Review, Special Emphasis Panels: Alexandria, VA, March 13-14, 2007 Atlanta, GA, September 1, 2006 Baltimore, MD, November 2-3, 2005 Washington D.C., October 25, 2005 Washington D.C., November 5, 2004 Atlanta, GA, June, 2001 Atlanta, GA, July, 2001 Ohio State University Research Enhancement Proposals Pilot Project (Nov ) University of Cincinnati ERC pilot projects ( ) Member: Program Chair: Committees: American Public Health Association North American Agromedicine Consortium Farm Safety 4 Just Kids Kentucky Partnership for Farm Family Health and Safety National Institute for Farm Safety Pre-program conference, Southern Agromedicine Consortium, Charleston, SC (Fall 1994) Southern Agromedicine Consortium (Spring 1994) Research Committee, National Institute for Farm Safety, 2005 present Consultant, Institutional Review Board, Farm Safety 4 Just Kids, Earlham, Iowa, Executive Committee, North American Agromedicine Consortium, 1999 present Professional Activities: National and International (continued):

322 Invited Seminars: Robert H. McKnight, MPH, ScD Page 28/32 Consensus Development Committee: Occupational Health and Safety of Migrant Children, National Children s Center for Rural and Agricultural Health and Safety, Marshfield, WI, Steering Committee, National Children s Center for Rural and Agricultural Health and Safety, Marshfield, Wisconsin ( ). Planning Committee, Research Track Program, Midwest Migrant Stream Forum (1998) Action Board, American Public Health Association (elected for 3-year term, ) National Committee for Childhood Agricultural Injury Prevention, NIOSH/Bureau of Maternal and Child Health ( ) Section Council, Injury Control and Emergency Medical Services Section, American Public Health Association (elected) ( ) Planning Committee, Injury Control and Emergency Medical Services Section of American Public Health Association, for the 1996 Third International Conference on Injury Prevention and Control, Melbourne, Australia ( ) Planning Committee, Agricultural Health Issues Program, American Rural Health Association Convention, San Francisco (May 1994) Working Group on Epidemiologic Perspectives, Childhood Agricultural Injury Symposium, National Farm Medicine Center, Marshfield, WI (April 1992) Membership Committee, Injury Control Special Interest Group, American Public Health Association ( ) Overview of Southeast Center for Agricultural Health and Injury Prevention. Presentation to director and staff of the CDC/NIOSH Alaska Field Station, Anchorage, AK, May 10, Challenges for Health, Injury Prevention and Pesticide Surveillance in Agricultural Communities, seminar presented to the residents of Hamilton, Australia at the Western District Health Service, April 28, Issues in Agricultural Health and Safety, presented to the physicians and house staff at the Western District Health Service, Hamilton, Australia, April 28, University of Alabama Rural Medical Scholars, Lunch Discussion, Tuscaloosa, AL, September 12, 2004 University of Texas Health Center at Tyler Southwest Agricultural Center, Tyler, TX. Epidemiologic Surveillance of Agricultural Chemicals in the Mississippi Delta: A New Multi-state Approach. (Mar. 21, 2001) Alcorn State University, Natchez, MS. Agricultural Safety and Awareness Programs for Youth. (Jan. 27, 2000)

323 Professional Activities: National and International (continued): Robert H. McKnight, MPH, ScD Page 29/32 Finnish Institute of Occupational Health, Kuopio Regional Institute, Kuopio, Finland. Agricultural Health and Injury Problems in the Southeastern United States. (Jan. 14, 1999) North Carolina State University, Department of Toxicology, Agromedicine Program. Linking medicine and agriculture to improve farmers health: Lessons learned and new opportunities (December 1997) Children s Environmental Risks, American Industrial Health Council Annual Meeting, Washington, DC (December 1997). East Carolina University School of Medicine. Building an agromedicine program (December 1997). Swedish Agricultural University, Division of Work Science, Alnarp, Sweden, Farm health and injury problems in the Southeast US (September 1, 1996). University of Cincinnati College of Medicine, Department of Environmental Health. Overview of health and safety research issues in agriculture (October 1994). University of North Carolina at Chapel Hill, School of Public Health. The research agenda in Kentucky on agricultural health and injury control (September 1993). NIOSH/CDC, Division of Surveillance, Hazard Evaluations, & Field Studies, Cincinnati, Ohio. Focus group interviews: An innovative method for behavioral risk factor surveillance in agriculture (August 1992). WK Kellogg Foundation, featured in 30-minute video tape on agricultural health and safety, Harvest of Danger; Season of Hope (1992) Southeast Region Injury Control Network, Atlanta, GA (December 1992) NIOSH Division of Respiratory Disease Studies, Morgantown, WV (November 1992). Farm Tractor Rollover Prevention Symposium, NIOSH Division of Safety Research, Morgantown, WV (1990) Aeromedical Transport Association Convention, Nashville, TN, Strategies for Injury Prevention (September 1990) Professional Activities: State and Local: Consultant: Montgomery County Health Department, Mt. Sterling, KY (2003 present) Kentucky Regional Poison Center, Louisville (2001) Kentucky Division of Epidemiology, Fatality Assessment Control Evaluation (FACE) grant (1994) University of Kentucky Cooperative Extension Service, Respiratory and hearing screening of pork producers (1994) Kentucky Cabinet for Human Resources, Department for Health Services, Kentucky Health Interview and Examination Survey (KHIES) ( )

324 Robert H. McKnight, MPH, ScD Page 30/32 Professional Activities: State and Local (continued): Kentucky Division of Epidemiology, contributor for grant application, Occupational Health Nurses in Agricultural Communities, funded, CDC/NIOSH Award #U06/CCU (1991) Ashland Oil Medical Department, Ashland, KY (1990) Invited Speaker: Kentucky Agricultural Leadership Summit, Louisville, KY, Migrant farm worker health issues in Kentucky: Problems and solutions. (November 1998) 29th Annual University of Kentucky Family Medicine Review, Lexington, KY, Farm family health and safety for clinical practice (Feb. & Nov. 1998) Moderator, Child Labor Issues, 3rd Annual Kentucky Injury Control Conference, Louisville, KY (April 1994) 15th Annual Family Practice Review Course, University of Louisville School of Medicine, Louisville, KY, Prevention of injuries in the rural workplace (June 1993) 2nd Annual Kentucky Injury Control Conference, Louisville, KY, Overview of agricultural injuries (September 1992) Kentucky Department for Health Services/Division of Epidemiology, Kentucky Injury Control Conference, Louisville, KY, Trauma care and injury prevention at the University of Kentucky (Sept. 1991) University of Kentucky Hospital Trauma Symposium, Lexington, KY, Epidemiology of trauma (June 1991) 13th Annual Family Practice Review Course, University of Louisville School of Medicine, Louisville, KY, Injury prevention: Agriculturalrelated injuries (June 1991) Committees: Good Samaritan Foundation Indigent Care Task Force ( ) Planning Committee, 2nd annual Kentucky Injury Control Conference, Kentucky Division of Epidemiology (1992) Planning Committee, 1st annual Kentucky Injury Control Conference, Kentucky Division of Epidemiology (1991) Media Interviews Coordinated with University of Kentucky, Office of Public Affairs: Interview: Student Practicum in Australia, UK Public Affairs, October 31, 2006 Interview: Hispanics Health Needs. The Courier-Journal, Associated Press, June, Interview: Farmworker Health Issues. Lexington Herald-Leader, September, Interview on U.S. Agricultural Health Issues. Swedish newspaper Arbetarskydd, September WLEX-TV: Migrant Farmworker Health Program. June Interview: Success of the Migrant Farmworker Health Program. Lexington Herald-Leader, March 16, 1999.

325 Robert H. McKnight, MPH, ScD Page 31/32 Interview: Update on Migrant Health Program. Georgetown News- Graphic, December 1, Professional Activities: State and Local (continued): Media Interviews Coordinated with University of Kentucky, Office of Public Affairs: Teaching and Advising: Press conference with Medical College Dean Emery Wilson: Announcement of DHHS funding for Kentucky Migrant Health Program. Lexington Herald-Leader, and local TV and radio coverage (June 1, 1998). Interview for University of Kentucky's research magazine: Improving farm safety and health, Odyssey, 12 (1): (1994) Importance of residential smoke detectors, Lexington Herald Leader, WKYT-TV, WLEX-TV, WEKU-FM (October 1994) News article: Haze surrounds Green Tobacco Sickness, Journal of the National Cancer Institute, 86 (6): (March 16, 1994) Interview: Feature article on farm hazards, Louisville Courier-Journal, pp. H1 2 (July 25, 1993) Featured guest, Health First Magazine: 30-minute discussion of agricultural health and safety initiatives in the College of Medicine, WKYT-TV, Lexington (August 1993) Interview: Research and Graduate Studies Communication and Advancement Office magazine: Science and You (1993) Press conference with Kentucky Governor Brereton Jones, Medical College Dean Emery Wilson and Medical Center Chancellor Peter Bosomworth: Announcement of NIOSH and WK Kellogg funding to prevent occupational health hazards in agriculture. WKYT-TV, WLEX-TV, WTVQ-TV, Lexington Herald-Leader, USA Today (October 1992) Current: Past: Coordinator, Agricultural Populations Emphasis Area of MPH and DrPH Programs, College of Public Health (2001 present). Course Director: Special Topics in Public Health: Health of Agricultural Populations (CPH 728), 3 credit hours (2002 present). Course Director: Injury Epidemiology and Control (CPH 810), 3 credit hours (1999 present). Course Director: Special Topics in Public Health: Advanced Agricultural Health (CPH 728), 3 credit hours (2007 present). Course Director: Research Design in Public Health (Preventive Medicine 675), 4 credit hours, ( ) Course director, Epidemiology (Preventive Medicine 521), 4 credit hours ( )

326 Robert H. McKnight, MPH, ScD Page 32/32 Course director, Topics in Advanced Epidemiology (Preventive Medicine 621), 2 credit hours ( ) Teaching and Advising (continued): New Courses Developed: Course Substantially Revised: Funding for Teaching: Coordinator of epidemiology and biostatistics sections, Preventive Medicine & Environmental Health (PM 821); for second year medical students ( ) Advanced Agricultural Health (3 semester hours). Taught Fall, 2007 Injury Epidemiology and Control (3 semester hours). Taught 1999, 2002, 2004, 2006 Health of Agricultural Populations (3 semester hours). Taught 2003, 2005, 2007 Research Design in Public Health (4 semester hours). Taught in 1998 Advanced Topics in Epidemiology (2 semester hours). Taught 1991 to 1994 Epidemiology (4 semester hours). Taught 1990 to 1995 Health of Agricultural Populations Emphasis Area ( ), a subcomponent of the CDC/NIOSH Southeast Center for Agricultural Health and Injury Prevention Center grant, provided funds for coursework development, student support, and student travel for MPH and DrPH students emphasizing agricultural health/safety in four departments: Health Behavior; Epidemiology; Health Services Management; Preventive Medicine/Environmental Health. Total = approximately $74,394 per year Doctoral Committees (* served as Chair): Ellen Rasnake, DrPH candidate (2007 present) Lisa Cave, PhD candidate, College of Business (2004) * Phyllis Bryden, DrPH candidate ( ) Lisa Whitis, PhD program, Dept. of Statistics ( ) Master s Committees, MPH Program (* served as Chair): * Justin Blackburn, * Maria Gomez, 2005

327 Robert H. McKnight, MPH, ScD Page 33/32 Steve Prather, 2004 Andrea Davis Brown, 2004 Teaching and Advising (continued): Master's Committees, MSPH Program (* served as Chair): Other: 2002: *Phyllis Bryden, BS (winner of 2002 Student Research Award from School of Public Health) 1999: Tim Kelly, BS 1997: *Sue Billings, DVM 1996: *Sara Dawson, MA *John Stea, MD John Keane, BA 1994: *Abraham Mouton, MD Chipper Griffith, MD Lynn Price, DMD Pamella Shaw, DMD 1993: Andy Kazmers, MD Scott Prince, MD Eric Levine, MD PhD 1992: *Richard Lorenz, MD Daniel Wolens, MD 1991: Craig Tokowitz, MD Jeff Kelefant, MD Undergraduate Thesis Committee Chair * Chris Garnett, B.S. student in Biology, and Gains Center Scholar, DrPH Student Practicum Phyllis Bryden ( ) Nancy Johnson ( ) Independent Study Phyllis Bryden, MPH Student (Spring 2001) Michael Auslander, DVM Robert Collins, MD Clinical practicum preceptor (Fall 1999) Deirdre Lay, MSN student, UK College of Nursing (NUR 614) Independent study for residents in Preventive Medicine, (PM770, PM780, PM790) J. Stea, MD A. Mouton, MD R. Lorenz, MD Supervisor, summer work-study activities for medical students. Lauren Larson (1994) Scott Hoffman (1991) Leslie Husband (1990)

328 Robert H. McKnight, MPH, ScD Page 34/32 End Rev. Dec 10, 2007

329 Biostatistics Department Faculty CVs

330 Biostatistics Department Faculty Primary Faculty Richard J. Kryscio (Chair) Richard J. Charnigo, Jr. Marta S. Mendiondo Adam J. Branscum Heather M. Bush Chong Wang David W. Fardo Adjunct Faculty Brent Shelton Mary Kay Rayens

331 CURRICULUM VITA Richard John Kryscio 311 Sanders-Brown Ctr. On Aging 1602 Martha Court 800 South Limestone Lexington, KY Lexington, KY (859) (859) BORN: December 19, 1944 Pottsville, Pennsylvania MARITAL STATUS: Married, 1966; 5 children DEGREES: B.A. (Magna Cum Laude) Mathematics 1966 King s College, Pennsylvania M.S. Statistics 1968 SUNY at Buffalo Ph.D. Statistics 1971 SUNY at Buffalo EXPERIENCE: Staff Fellow, Biometry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. August, 1971 to August, Assistant Professor, Department of Mathematical Sciences, Northern Illinois University, September, 1972 to September, Associate Professor, Department of Mathematical Sciences, Northern Illinois University, September, 1977 to August, Visiting Associate Professor, Department of Statistics, University of Kentucky, August, 1981 to May, Associate Professor and Director of Mathematical Sciences Consulting Laboratory, Department of Statistics, University of Kentucky, August, 1982 to May, Professor and Director of Mathematical Sciences Consulting Laboratory, Department of Statistics, University of Kentucky, August, 1986 to August, Chairman, Department of Statistics and Director, Biostatistics Consulting Unit, Medical Center Campus, University of Kentucky, August, 1990 to July, Professor, Department of Statistics, and Director of Biostatistics Consulting Unit, Medical Center Campus, University of Kentucky, August, 1989 to December, Professor, Department of Statistics and the Kentucky School of Public Health, and Director of Biostatistics Consulting Unit, January 2001 to June, Professor, Department of Statistics. College of Arts and Sciences and Chair, Department of Biostatistics, College of Public Health, July, 2004 to present.

332 Kryscio 2 RESEARCH INTERESTS: applied probability, including epidemic theory, and spatial statistics and biostatistics/epidemiology including Alzheimer s disease, cancer control, clinical trials, clustering of diseases, incidence of stroke and mortality due to carotid endarterectomy, prevention trials, longitudinal data analysis. PUBLICATIONS Category A: Basic Research Kryscio, R.J. and Severo, N.C. Some properties of an extended simple stochastic epidemic model involving two additional parameters. Mathematical Biosciences, 5, 1969, 1-8. Kryscio, R.J. The transition probabilities of the extended simple stochastic model and the Haskey model. Journal of Applied Probability, 9, 1972, Kryscio, R.J. On estimating the infection rate of the simple stochastic epidemic. Biometrika, 59, 1972, Kryscio, R.J. On the extended simple stochastic epidemic model. Biometrika, 61, 1974, Kryscio, R.J. The transition probabilities of the general stochastic epidemic model. Journal of Applied Probability, 12, 1974, Kryscio, R.J. and Severo, N.C. Computational and estimation procedures in multidimensional rightshift processes and applications. Advances in Applied Probability, 7, 1975, Saunders, R. and Kryscio, R.J. Parameter estimation for the carrier-borne epidemic model. Journal of the Royal Statistical Society B, 38, 1976, Kryscio, R.J. and Saunders, R. A note on the cost of carrier-borne, right-shift, epidemic models. Journal of Applied Probability, 13, 1976, Kryscio, R.J. and Severo, N.C. Statistical inferences for a stochastic epidemic model proposed by Gart. Management Science, 7, 1977, Billard, L. and Kryscio, R.J. The transition probabilities of a bounded bivariate pure death process. Mathematical Biosciences, 37, 1977, Saunders, R., Lefevre, C. and Kryscio, R.J. A note on the expected number of survivors in supercritical carrier-borne epidemics. Journal of Applied Probability, 16, 1979, Saunders, R., Kryscio, R.J. and Funk, G.M. Limiting results for arrays of binary random variables under sparseness conditions. Journal of Applied Probability, 16, 1979, Kryscio, R.J., Saunders, R. and Funk, G.M. Normal approximations for binary lattice systems. Journal of Applied Probability, 17, 1980, Saunders, R., Kryscio, R.J. and Funk, G.M. Poisson limits for a hard-core clustering model. Stochastic Processes and Their Applications, 12, 1982,

333 Kryscio 3 Kryscio, R.J. and Saunders, R. On interpoint distances for planar Poisson cluster processes. Journal of Applied Probability, 20, 1983, Griffith, W., Kryscio, R.J. and Purdue, P. A stochastic model of particle shattering. Advances in Applied Probability, 16, 1984, Kryscio, R.J. and Lefevre, C. On the extinction of the S-I-S stochastic logistic epidemic model. Journal of Applied Probability, 27, 1989, Kryscio, R.J. and Malice, M.P. On modeling the incidence of AIDS. Proceedings of the Conference: Stochastic Processes in Epidemic Theory. In Lecture Notes in Biomathematics, 86, 1990, 46-58, Heidelberg, Springer-Verlag. Malice, M.P. and Kryscio, R.J. Some stochastic models for AIDS. IMA Journal in Applied Mathematics in Biology and Medicine, 6, 1989, Kryscio, R.J. and Lefevre, C. Measuring the severity of disease clustering using Tango s index. Mathematical Biosciences, 107, 1991, Rayens, M.K. and Kryscio, R.J. Properties of Tango s index for detecting clustering in time. Statistics in Medicine, 12, 1993, McKnight, R.H., Kryscio, R.J., Mays, J.R., and Rodgers, G.C. Spatial and temporal clustering of an occupational poisoning: the example of green tobacco sickness. Statistics in Medicine, 15, 1996, Lanska, D.J. and Kryscio, R.J. Modified Box: plots for asymmetric distributions. Proceedings of Section on Statistical Graphics, Joint Statistical Meetings, Chicago, 50-53, Peterson, P.M. and Kryscio, R.J. Edgeworth approximations of null and alternative probabilities for quadratic epidemiologic clustering statistics. Proceedings of Section on Epidemiology, Joint Statistical Meetings, Chicago, Kryscio, R.J. Tango Index. Encyclopedia of Statistical Sciences (S. Kotz & C.B. Reed, Eds.). Update Volume 2: , Cline, G.C. and Kryscio, R.J. Contagion distributions for defining disease clustering in time. Journal of Statistical Planning and Inference, 78: , Mendiondo, M.S., Ashford, J.W., Kryscio, R.J., and Schmitt, F.S. Modeling Mini-Mental State Exam changes in Alzheimer s disease. Statistics in Medicine, 19: , Kay, L., Wood, C.L, and Kryscio, R.J. On the optimality of the maximum cell count in cluster detection. Proceedings of the Joint Statistical Meetings, August, Schmitt, F.A., Miller, J.P., and Kryscio, R.J. Promoting interactions with basic scientists and clinicians: summary of a panel session. Statistics in Medicine, 19: , Salazar, J.C., Tyas, S.L., Snowdon, D.A., Desrosiers, M.F., Riley, K.P., Mendiondo, M.S., and Kryscio R.J. Estimating intensity functions on multi-state Markov models with application to the NUN study. Proc Joint Statistical Meetings, San Francisco, August, 2003 Kryscio, R.J., Mendiondo, M.S., Schmitt, F.A., and Markesbery, W.R. Designing a large prevention trial: statistical issues. Statistics in Medicine, 23: , 2004

334 Kryscio 4 Kryscio, R.J. Lefevre, C. On the extinction of the S-I-S stochastic logistic epidemic. Previously published in J Applied Prob. and now republished in a book edited by W. Chen and entitled: Statistical methods in computer security (Chapter 14), Marcel- Dekker/ CRC Press, Salazar, J., Schmitt, F.A., Yu, L., Mendiondo, M., Kryscio, R.J. Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia. Statistics in Medicine, 26: , Slavova S, Bunn T., Pavlov D, Kryscio R Surveillance of occupational drivers using k nearest neighbor methods on the line. Proceedings of the Section on Epidemiology, Joint Statistical Meetings, Seattle, Aug, 2006, Category B: Epidemiologic Research, Biostatistics, and Consulting Kryscio, R.J., Meyers, M.H., Prusiner, S.T., Heise, H.W. and Christine, B.W. Space-time clustering of Hodgkin s disease in Connecticut Journal of the National Cancer Institute, 50, 1973, Murphy, E.A., Cramer, D.W., Kryscio, R.J., Brown, C.C. and Pierce, E.R. Gonadal mosaicism and genetic counseling for X-linked recessive lethals. American Journal of Human Genetics, 26, 1974, Mantel, N., Kryscio, R.J. and Meyers, M.H. Tables and formulas for extended use of the Ederer- Meyers-Mantel disease clustering procedure. American Journal of Epidemiology, 104, 1976, Funk, G.M. and Kryscio, R.J. Equity and the property tax: comments on two seemingly unrelated conceptual frameworks. National Tax Journal, 31, 1978, Johnson, M.C., Anderson, R.L., Kryscio, R.J. and Siegel, M.R. Sampling procedures for determining endophyte content in tall fescue seed lots by ELISA. Phytopathology, 73, 1983, Fried, A.M., Woodring, J.H., Loh, F.K., Lucas, B.A. and Kryscio, R.J. The medullary pyramid index: An objective assessment of prominence in renal transplant rejection. Radiology, 149, 1983, Woodring, J.H., Loh, F.K. and Kryscio, R.J. An evaluation of the plain radiographic manifestations of mediastinal hemorrhage. Radiology, 151, 1984, Hall, J., Gruber, J., Humphries, L. and Kryscio, R.J. Performance of older adolescents on the Briuninks-Oseretsky test of motor proficiency: A prelude to normative data. American Corrective Therapy Journal, 38, 1984, Raynor, W. and Kryscio, R.J. Forming contacts between university consulting groups and industry and/or local and state governments. Proceedings of the Wisconsin Workshop on Consulting Intern Programs (B. Joiner, ed.). Statistical Laboratory: Madison, WI, 1984, Sisken, B.F., Fowler, I., Barr, E.J. and Kryscio, R.J. The threshold quantity of nerve required to induce limb regeneration in the chick embryo. Journal of Neuroscience Research, 12(4), 1984,

335 Kryscio 5 Maruyama, Y., Kryscio, R.J., Wood, C., VanNagell, J.R., Donaldson, E., Hanson, M. and Yoneda, J. Results of treatment of primary and recurrent adenocarcinoma of the corpus uteri with californium Radiation Oncology, 11, 1985, Maruyama, Y., Kryscio, R.J., VanNagell, J.R., Yoneda, J., Donaldson, E., Hanson, M., Beach, J., Feola, J., Martin, A. and Parker, C. Advanced cervical cancer cured better by neutron brachytherapy versus conventional radiotherapy. The Lancet, May, 1985, Maruyama, Y., Kryscio, R.J., VanNagell, J.R., Yoneda, J., Donaldson, E., Hanson, M., Beach, J., Feola, J., Martin, A. and Parker, C. Clinical trial of 252 of neutron brachytherapy versus conventional radiotherapy for advanced cervical cancer. Radiation Oncology, 11, 1985, Humphries, L., Gruber, J., Hall, J., McKay, S. and Kryscio, R.J. Motor proficiency in depressed adolescent inpatients: neuropsychiatric, clinical and biochemical correlates. Journal of Developmental and Behavioral Pediatrics, 6, 1985, Maruyama, Y., VanNagell, J.R., Donaldson, E., Kryscio, R.J., Wood, C.L., Hanson, M. and Yoneda, J. Results of treatment of primary and recurrent adenocarcinoma of the corpus uteri with californium Radiation Oncology, 11, 1985, Feola, J.M., Maruyama, Y. and Kryscio, R.J. Treatment of primary radiogenic C57BL mouse cell leukemia/lymphoma by 1,2 BIS (2-chloreathyl)-1-Nitrosouea chemotherapy and adjuvant cell therapy. Japanese Journal of Cancer Research, 76, 1985, McCready, R.A., Price, M.A., Kryscio, R.J., Hyde, G.L., Mattingly, S.S. and Griffen, W.O. Failure of antiplatelet therapy with ibuprofen (Motrin) to prevent neointimal fibrous hyperplasia. Journal of Vascular Surgery, 2, 1985, VanNagell, J.R., Maruyama, Y., Donaldson, E., Hanson, M., Gallion, H.H., Powell, D.E., Kryscio, R.J. and Beach, J.L. Phase II clinical trial using fast Cf-252 neutron brachytherapy, external pelvic radiation and extra fascial hysterectomy in the treatment for bulky barrel-shaped, Stage-1B cervical cancer. Cancer, 57, 1986, Kryscio, R.J. Clinical trials: Principles versus practice. Proceedings of the International Neutron Therapy Workshop, Nuclear Science Applications, Section B, 2, 1986, Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E., Gallion, H., Rowley, K., Kryscio, R.J. and Beach, J.L. Phase I-II clinical trial of californium-252. Cancer, 59, 1987, Gallion, H., Maruyama, Y., VanNagell, J.R., Donaldson, E., Rowley, K., Yoneda, J., Beach, J.L., Powell, D.E. and Kryscio, R.J. Treatment of Stage-IIIB cervical cancer with californium-252 fastneutron brachytherapy and external photon therapy. Cancer, 59, 1987, Karan, P.P., Singh, S. and Kryscio, R.J. Adoption of family planning and modern preventive health care services in rural India. Journal of African and Asian Studies, 33, 1987, Rhodes, R.A., Fried, A.M., Lorman, J.G. and Kryscio, R.J. Tomographic levels for intravenous urography: CT-determined guidelines. Radiology, 163, 1987, Legg, D.E., Barney, R.J. and Kryscio, R.J. Improved sampling plans for monitoring alfalfa weevil (coleoptera: curculionidae) larva infestations in Kentucky. Journal of Economic Entomology, 81(1), 1988,

336 Kryscio 6 Patchell, R.A., Maruyama, Y., Tibbs, P.A., Beach, L.J., Kryscio, R.J, Young, B.A. Neutron interstitial brachytherapy for malignant gliomas: a pilot study. Journal of Neurosurgery, 68, 1988, Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E., Gallion, H., Patel, P. and Kryscio, R.J. Feasibility study of californium-252 for treatment of Stage-IV cervical cancer. Cancer, 61, 1988, Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E., Gallion, H., Higgins, R., Powell, D., Turner, C. and Kryscio, R.J. Efficacy of californium-252 neutrons versus gamma brachytherapy for eradication of bulky localized cervix cancer: single institution study. Journal of National Cancer Institute. Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E., Gallion, H.H., Higgins, R.V., Powell, D.W., Kryscio, R.J. and Berner, B. Dose response and failure pattern for bulky or barrel-shaped Stage-IV cervical cancer treated by combined photon irradiation and extrafascial hysterectomy. Cancer, 63, 1988, Noland, M., Kryscio, R.J., Riggs, R.S, Linville, L.H., Perritt, L.J. and Tucker, T.C. Saliva cotinine and thiocyanate: chemical indicators of cigarette and smokeless tobacco use in adolescents. Journal of Behavioral Medicine, 11, 1988, Gallion, H.H., VanNagell, J.R., Donaldson, E., Higgins, R.V., Powell, D.E. and Kryscio, R.J. Adjuvant and alkylating chemotherapy in patients with Stage-I epithelial ovarian cancer. Cancer, 63, 1989, Gruber, J.J., Hall, J.W., McKay, S.E., Humphries, L.L. and Kryscio, R.J. Motor proficiency and neuropsychological function in depressed adolescent inpatients: a pilot investigation. Adapted Physical Activity Quarterly, 6(1), 1989, Saphner, T., Gallion, H.H., VanNagell, J.R., Kryscio, R.J. and Patchell, R.A. Neurologic complications of cervical cancer: a review of 2,244 cases. Cancer, 64, 1989, Gallion, H.H., VanNagell, J.R. Jr., Powell, D.E., Donaldson, E.S., Higgins, R.V., Kryscio, R.J., Pavlik, E.J. and Nelson, K. Stage-I serous papillary carcinoma of the endometrium. Cancer, 63, 1989, Martin, C.A., Vore, M., Potts, B.D., Kryscio, R.J., Norton, J.C., Madigan, J.M., Welsh, R.J., Heffron, W.M., Liu, J.P. Methylphenidate plasma concentrations in chronically and acute treated latency-age children. Pharmacology, 39, 1989, Gallion, H.H., VanNagell, J.R., Powell, D.E., Donaldson, E.S., Higgins, R.V., Kryscio, R.J., Pavlik, E.J., Nelson, K. Stage I serous papillary carcinoma of the endometrium. Cancer, 63, 1989, Pigman, J.G., Agent, K.R., Deacon, J.A. and Kryscio, R.J. Evaluation of unmanned radar installations. Transportation Research Record, 1244, 1989, Sparks, D.L., Oeltgen, P.R., Kryscio, R.J. and Hunsakar, J.C. Comparison of chemical methods for determining postmortem interval. Journal of Forensic Sciences, 34, 1989, Noland, M., Kryscio, R.J., Riggs, R.S., Linville, L.H., Perritt, L.J. and Tucker, T.C. Use of snuff, chewing tobacco and cigarettes among adolescents in a tobacco-producing area. Addictive Behaviors, 15, 1990,

337 Kryscio 7 Higgins, R.V., VanNagell, J.R., Donaldson, E.S., Gallion, H.H., Pavlik, E.J. and Kryscio, R.J. The efficacy of laser therapy in the treatment of cervical interpithelial neoplasia. Gyn. Onc., 36, 1990, Bondada, S., Morris, J. and Kryscio, R.J. Phenotypic and functional properties of B lymphocytes from aged mice. Mechanism of Aging and Development, 51, 1990, Patchell, R.A., Tibbs, P.A., Walsh, J.W., Dempsey, R.J., Maruyama, Y., Kryscio, R.J., Markesbery, W.R., MacDonald, J.S. and Young, B. A randomized trial of surgery in the treatment of simple metastasis to the brain. New England Journal of Medicine, 1990, Sparks, D.L., Hunsakar, J.C., Scheff, S.W., Kryscio, R.J., Hanson, J.C. and Markesbery, W.R. Cortical senile plagues in coronary artery disease, aging and Alzheimer s disease. Neurology of Aging, 11, 1990, Arcury, T.A., Williams, B.J. and Kryscio, R.J. Birth seasonality in a rural U.S. country, American Journal of Human Biology, 2, 1990, Maruyama, Y., Feola, J., Kryscio, R.J. and Wood, C.L. Cf-252 leukemogenesis in C57BL mouse: effect of mixed low dose rate Cf-252 and photon radiation schedule. Strahlentherapie and Oncologies, 6, 1990, Smith, H.A., Coons, S.J., Parker, C.L. and Kryscio, R.J. Pharmacy patronage and marketing: strategies for success. NARD Journal, February, 1991, VanNagell, J.R., DePriest, P.D., Puls, L.E., Donaldson, E.S., Gallion, H.H., Pavlik, E.J., Powell, D.E. and Kryscio, R.J. Ovarian cancer screening in asymptomatic postmenopausal women by transvaginal sonography. Cancer, 68(3), 1991, Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E.S., Gallion, H.H., Powell, D. and Kryscio, R.J. A review of Cf-252 neutron brachytherapy for cervical cancer. Cancer, 68(6), 1991, Maruyama, Y., VanNagell, J.R., Powell, D., Yoneda, J., Donaldson, E.S., Gallion, H.H. and Kryscio, R.J. Predictive value of specimen histology after preoperative radiotherapy in the treatment of bulky/barrel carcinoma of the cervix. Am. J. Clin. Oncol., 15(2), 1991, Miller, J.P., Patchell, R., Yaes, R., Cin, H.W., Berner, B., Wierzbicki, J., Kryscio, R.J., Maruyama, Y. and Young, A.B. Preliminary report on Cf-252 neutron interstitial implant therapy for glioblastome multiforme: a phase I trial. Nuclear Science Applications, 4, 1991, Hall, L.A., Gurley, D.N., Sachs, B. and Kryscio, R.J. Psychological predictors of maternal mental health, parenting attitude, and child behavior in single parent families. Nursing Research, 40(4), 1991, Maruyama, Y., VanNagell, J.R., Yoneda, J., Donaldson, E.S., Gallion, H.H. and Kryscio, R.J. Cf-252 neutron brachytherapy treatment for cure of cervical cancer. Nuclear Science Applications, 4, 1991, Maruyama, Y., Donaldson, E.S., VanNagell, J.R., Yoneda, J., Gallion, H.H., Powell, D. and Kryscio, R.J. Specimen finding and survival after preoperative Cf-252 neutron brachytherapy for stage II cervical carcinoma. Gynecologic Oncology, 43, 1991,

338 Kryscio 8 Smith, H.A. and Kryscio, R.J. Elaboration of relationships among patronage variables. Chapter 15, Marketing Pharmaceutical Services: Patron Loyalty, Satisfaction, and Preferences (H.A. Smith and S.J. Coons, eds.), Pharmaceutical Products Press, New York, Smith, H.A., Fink, J.L. and Kryscio, R.J. Motivational factors related to decision on pursuing graduate study. Am. J. of Pharmaceutical Education, 56, 1992, Pettigrew, L.C. and Kryscio, R.J. Thromboxane receptor antagonism and synthase inhibition in cerebral ischemia. Prostaglandins, Leukotrienes and Essential Fatty Acids, 48(3), 1993, Smith, C.D., Gallenstein, L.G., Layton, W.J., Kryscio, R.J. and Markesbery, W.R. Neuropathology and P-magnetic resonance spectroscopy in Alzheimer and Pick s disease. Neurobiology of Aging, 14, 1993, Maruyama, Y., Yoneda, J., VanNagell, J.R., Gallion, H.H., DePriest, P., and Kryscio, R.J. An evaluation of postoperative radiotherapy versus observation for operable cervical cancer treated with preoperative radiation. ECHO, 9, 1993, Maruyama, Y., VanNagell, J.R., Yoneda, J., DePriest, P. and Kryscio, R.J. Clinical evaluation of 252CF neutron intracavity therapy for primary endometrial adenocarcinoma. Cancer, 71(12), 1993, Lucas, B.A., Waid, T.H., Thompson, J.S., Brown, S.A., McKeown, J.W., Kryscio, R.J. and Prebeck, R.J. Comparison of T10B9.1A-31 and OKT3 in treating acute renal allograft rejection. Transplantation Proceedings, 25(1), 1993, Lanska, D.J. and Kryscio, R.J. Geographic distribution of hospitalization rates, case fatality and mortality from stroke in the United States. Neurology, 44, 1994, Maruyama, Y., VanNagell, J.R., Yoneda, J., Powell, D., Gallion, H.H. DePriest, P. and Kryscio, R.J. Histological monitoring of tumor response after preoperative radiotherapy for Stage IB/II cervical cancer. ECHO, 10, 1994, Hunter, J.E., Trity, D.E., Howell, M.G., DePriest, P.D., Gallion, H.H., Andrews, S.J., Buckley, S.B., Kryscio, R.J. and VanNagell, J.R. The prognostic and therapeutic implications of cytologic atypia in patients with endometrial hyperplasia. Gynecologic Oncology, 55, 1994, Andrews, S.J., Williams, B.T., DePriest, P.D., Gallion, H.H., Hunter, J.E., Buckley, S.L., Kryscio, R.J. and VanNagell, J.R. Therapeutic implications of lymph nodal spread in lateral T_1 and T_2 squamores cell carcinoma of the valva. Gynecologic Oncology, 55, 1994, DePriest, P.D., Varner, E., Powell, J., Fried, A., Peels, L., Higgins, R., Shensen, D., Kryscio, R.J., Hunter, J.E., Andrews, S.J., and VanNagell, J.R. The efficacy of a sonographic morphology index in identifying ovarian cancer: a multi-institutional investigation. Gynecologic Oncology, 55, 1994, Ott, M., Schmidt, J., Young, B., Ott, L., Kryscio, R.J., McClain, C. Nutritional and metabolic variables correlate with amino acid forearm flux in patients with severe head injury. Critical Care Medicine, 22(3), 1994, Lanska, M.J., Lanska, D.J., Bauman, R.J., and Kryscio, R.J. A population based study of neonatal seizures in Fayette County. Kentucky Neurology, 45(4), 1995,

339 Kryscio 9 Pavlik, E.J., VanNagell, J.R., DePriest, P.D., Wheeler, L., Tatman, J.M., Boone, M., Sollais, S., Rayens, M.K., and Kryscio, R.J. Participation in transvaginal ovarian cancer screening: compliance, correlation factors, and costs. Gynecologic Oncology, 57, 1995, Noland, M.P., Kryscio, R.J., Hinkle, J., Riggs, R., Linville, L.H., Ford, V.Y., and Tucker, T.C. Relationship of personal tobacco-raising, parental smoking, and other factors to tobacco use among adolescents living in a tobacco-producing region. Addictive Behaviors, 21(3), 1996, Young, B., Ott, L., Kasarskis, E., Rapp, R., Hodes, K., Dempsey, R.J., Tibbs, P.A., Kryscio, R.J. and McClain, C. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. Journal of Neurotrauma, 13(1), 1996, Lanska, M.J., Lanska, D.J., Bauman, R.J., Allen, S.J., Slone, K.G., and Kryscio, R.J. Interobserver variability in the classification of neonatal seizures based on medical record data. Pediatric Neurology, 15(2), 1996, Puls, L.E., Duniho, T., Hunter, J.E., Kryscio, R.J., Blackhurst, D. and Gallion, H. The prognostic implication of ascites in advanced-stage ovarian cancer. Gynecologic Oncology, 61, 1996, Lanska, D.J. and Kryscio, R.J. Peripartum stroke and intracranial vensus thrombosis: results of the National Hospital Discharge Survey, Obstetrics and Gynecology, 89, 1997, Lanska, D.J. and Kryscio, R.J. Endarterectomy for asymptomatic internal carotid artery stenosis. Special invited editorial: Neurology, 46, 1997, Patchell, R.A., Yaes, R.J., Beach, L., Kryscio, R.J., Davis, D.G., Tibbs, P.A. and Young, B. A Phase I trial of neutron brachytherapy for the treatment of malignant gliomas. The British Journal of Radiology, 70, 1997, Miyoshi, Y., Zhang, Z., Ovadia, A., Lapchak, P.A., Collins, F., Hilt, D., Lebel, C., Kryscio, R.J. and Gash, D.M. Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in Parkinsonian monkeys. Ann. Neurol., 42, 1997, Kearns, C., Cass, W.A., Smoot, K., Kryscio, R.J. and Gash, D.M. GDNF protection against 6- OHDA: time dependence and requirement for protein synthesis. The Journal of Neuroscience, 17(18), 1997, Waid, T.H., Lucas, B.A., Thompson, J.S., McKeown, J.W., Brown, S., Kryscio, R.J., and Skeeter, L.J. Treatment of renal allograft rejection with T10B9.1A31 or OKT3: final analysis of a Phase II clinical trial. Transplantation, 64(2), 1997, Lanska, D.J. and Kryscio, R.J. In-hospital mortality following carotid endarterectomy. Neurology, 51(2), 1998, Noland, M.P., Kryscio, R.J., Riggs, R.S., Linville, L.H., Ford, V.Y. and Tucker, T.C. The effectiveness of a tobacco intervention program with adolescents living in a tobacco producing region. American J. Public Health, 88(12), , Patchell, R.A., Tibbs, P.A., Regine, W.F., Dempsey, R.J., Mohuiddin, M., Kryscio, R.J., Foon, K.A., Markesbery, W.R. and Young, B. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized controlled trial. JAMA, 280(17), , 1998.

340 Kryscio 10 Saxe, S.R., Wekstein, M.W., Kryscio, R.J., Henry, R.G., Cornett, C.R., Snowdon, D.A., Grant, F.T., Schmitt, F.A., Donegan, S.J., Wekstein, D.R., Ehmann, W.D., Markesbery, W.R. Alzheimer s Disease, dental amalgams and mercury. JADA, 130: , Smith, C.D., Umberger, G.H., Manning, E.L., Slevin, J.T., Wekstein, D.R., Schmitt, F.A., Markesbery, W.R., Zhang, Z., Gerhardt, G.A., Kryscio, R.J., Gash, D.M. Critical decline in fine motor hand movements in human aging. Neurology 53: , Smith, C.D., Anderson, A.H., Kryscio, R.J., Schmitt, F.A., Kindy, M.S., Blonder, L.X., Avisom, M.J. Altered brain activation in cognitively intact individuals at high risk for Alzheimer s disease. Neurology 53: , Anderson, J.W., Vichitibandra, S., Qian, W., and Kryscio, R.J. Long term maintenance after an intensive weight-loss program. J. Am. College Nutrition, 18(6): , Tasdemiroglu E, Patchell RA, Kryscio, R. Neurological complications of childhood malignancies. Acta Neurochir (Wein) 141(12): , Rockich KT, Hatton JC, Kryscio RJ, Young BA, Blouin RA. Effect of recombinant human growth hormone and insulin-like growth factor-1 administration on IGF-1 and IGF-binding protein-3 levels in brain injury. Pharmacotherapy, 19(12): , Lanska, D.J., Kryscio, R.J. Risk factors for peripartum and postpartum stroke and intracranial venous thrombosis. Stroke, 31: , Pavlik, E.J., DePriest, P.D., Gallion, H.H, Ueland, F.R., Reedy, M.B., Kryscio, R.J. and VanNagell, J.R. Ovarian volume related to age. Gyn. Onc. 77: , Pavlik EJ, Johnson TL II, Depriest PD, Andrykowski MA, Kryscio RJ, van Nagell JR Jr. Continuing participation supports ultrasound screening for ovarian cancer. Ultrasound Obstet. Gynecol., 15(5): , Anderson JW, Hanna TJ, Peng X, Kryscio RJ. Whole grain foods and heart disease risk. J Am Coll Nutr., 19(3 Suppl): 291S-299S, Hill K, Bucuvalas J, McClain C, Kryscio R, Martini RT, Alfaro MP, Maloney M. Pilot study of growth hormone administration during the refeeding of malnourished anorexia nervosa patients. J Child Adolesc. Psychopharmacol., 10(1): 3-8, VanNagell, J.R., DePriest, P.D., Reedy, M.B., Gallion, H.H., Ueland, F.R., Pavlik, E.J., and Kryscio, R.J. The efficacy of transvaginal sonographic screening in asymptomatic women at risk for ovarian cancer. Gyn. Onc., 77: , Lanska, D.J. and Kryscio, R.J. Thumb localizing test for detecting a lesion in the posterior columnmedial lemnisca system. J. Neuro. Sciences, 174: , Pavlik, E.J., Liu, C., DePriest, P.D., Gallion, H.H., Ueland, F.R., Kryscio, R.J., van Nagell, J. Relating ovarian size to age, menopausal status, and use of hormones. Letter to Editor. Gyn. Oncology, 80(2): , Kesler/West, M.L., Anderson, A.H., Smith, C.D., Avisom, M.J., Davis, C.E., Kryscio, R.J., Blonder, L.X. Neural substrates of facial emotion processing using fmri. Cognitive Brain Research 11: , 2001.

341 Kryscio 11 Mendiondo, M.S., Kryscio, R.J., Schmitt, F.A. Models of progression of AD: predicting disability and costs. Invited editorial, Neurology, 57: , Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Differences in functional magnetic resonance imaging activation by category in a visual confrontation naming task. J Neuroimaging, 11(2): , Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Women at risk for AD show increased parietal activation during a fluency task. Neurology, 58(8): , Reedy M, Gallion H, Fowler JM, Kryscio R, Smith SA. Contribution of BRCA1 and BRCA2 to familial ovarian cancer: a gynecologic oncology group study. Gynecol. Oncol., 85(2):255-9, Schilder JM, Thompson AM, DePriest PD, Ueland FR, Cibull ML, Kryscio RJ, Modesitt SC, Lu KH, Geisler JP, Higgins RV, Magtibay PM, Cohn DE, Powell MA, Chu C, Stehman FB, van Nagell J. Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy. Gynecol. Oncol., 87(1): 1-7, Wilder JL, Pavlik E, Straughn JM, Kirby T, Higgins RV, DePriest PD, Ueland FR, Kryscio RJ, Whitley RJ, van Nagell J. Clinical implications of a rising serum CA-125 within the normal range in patients with epithelial ovarian cancer: a preliminary investigation small star, filled. Gynecol Oncol. 2003; 89(2): Anderson TS, Regine WF, Kryscio RJ, Patchell RA. Neurologic complications of bladder carcinoma: a review of 359 cases. Cancer 2003; 97(9): Pulliam JF, Jennings CD, Kryscio RJ, Davis DG, Wilson D, Montine TJ, Schmitt FA, Markesbery WR. Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer s disease and correlation with APOE. Am J Med Genet. 2003; 119B(1): Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio RJ, Wekstein D, Smith C, Markesbery WR, Mattson MP. Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer s disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development. Neuromolecular Med. 2003; 3(1): Modesitt, S.C., Pavlik, E.J>, Ueland, F.R., DePriest, P.D., Kryscio, R.J., vannagell, J.R. Risk of malignancy in unilocular ovarian cyctic tumors less than 10 centimeters in diameter, Obstet Gynecol 102(3): , 2003 Ueland, F. R., De Priest, P.D., Pavlik, E.J., Kryscio, R.J., van Nagell, J.R.Jr. Preoperative differentiation of malignant indexing and Doppler flow sonography Gynecol Oncol 91(1): 46-50, 2003 Mendiondo, M.S., Ashford, J.W., Kryscio, R.J., Schmitt, F.A. Designing a Brief Alzheimer Screen (BAS). Journal of Alzheimer s Disease, 5(5), , Hopenhayn, C., Moore, D. B., Huang, B., Redmond, J., Tucker, T.C., Kryscio, R.J., Boissonneault, G.A. Patterns of colorectal cancer incidence, risk factors and screening in Kentucky. Southern Medical Journal, May, Wilder, J.L, Shajahan, S., Khattar, N.H., Wilder, D.M., Yin, J., Rushing, R.S., Beaven, R., Kaetzel, C. Ueland, F.R., Van Nagell, J.R., Kryscio, R.J., Lele, S.M. Tamoxifen-associated malignant

342 Kryscio 12 endometrial tumors: pathologic features and expression of hormone receptors estrogen-alpha, estrogen-beta and progesterone; a case controlled study Gynecol Oncol 92(2): , Hirschowotz, E.A., Foody, T., Kryscio, R., Dickson, L., Sturgill, J., Yanelli, J. Autologous dendritic cell vaccines for non-small cell lung cancer. J Clin Oncol 22(14): , 2004 Kryscio, R.J. Invited online commentary. What is an intraclass correlation coefficient? Crucial concepts for primary care researchers. May/June 2004 issue of Annals of Family Practice. Thompson, J.S., Pomerory, C., Kryscio, R.J., Humphries, S., Brown, S.A., Reece, D., Howard, D.S., Phillips, G. TNF alpha and IL-6 levels as outcome predictors in high risk patients undergoing a novel nonmyeloablative allogenic stem cell transplant. Biol. Blood Marrow Transplant. 2004, 10(12): Regine, W.F., Rogozinska, A., Kryscio, R.J., Tibbs, P.A., Young, A.B., Patchell, R.A. Recursive partitioning analysis classifications I and II: applicability evaluated in a randomized trial for resected single brain metastases. Am. J. Clin. Oncol., 2004, 27(5): Slevin, J., Gerhardt, G. A., Smith, C.D., Gash, D.M., Kryscio, R., Young, A. B. Research on Parkinson disease. J Neurosurg., 2005, 102(2): 401. Slevin, J., Gerhardt, G. A., Smith, C.D., Gash, D.M., Kryscio, R., Young, A. B. Improvement of bilateral motor functions in patients with Parkinson s disease through the unilateral infusion of glial cell line-derived neurotrophic factor. J Neurosurg., 2005, 102(2): Miller, C.S., Avdiushko, S.A., Kryscio, R.J., Dananbar, R.J., Jacob, R.J. Effect of prophylactic valacyclovir on the presence of human herpesviruses DNA in saliva of healthy individuals following dental treatment. J. Clin. Microbiol., (5): Smith, C.D., Walton A., Loveland A.D., Umberger, G.H., Kryscio R.J., Gash D.M. Memories that last in old age: motor skill learning and memory preservation. Neurobiol. Aging, 2005, 26(6): Kasarskis E.J., Dempsey-Hall L., Thompson M.M., Luu L.C., Mendiondo, M.S., Kryscio R.J. Rating the severity of ALS by caregivers over the telephone using the ALSFRS-R. Amyotroph Lateral Scler Other Motor Neuron Disord, 2005, 6(1): Smith C.D., Kryscio R.J., Schmitt F.A., Lovell M.A., Blonder L.X., Rayens W.S., Andersen A.H. Longitudinal functional alterations in asymptomatic women at risk for Alzheimer s disease. J Neuroimaging, 2005, 15(3): Ueland F.R., DePriest P.D., Desimone C.P., Pavlik E.J., Lele S.M., Kryscio R.J., vannagell J.R. Jr. The accuracy of examination under anesthesia and transvaginal sonography in evaluating ovarian size. Gynecol. Oncol., 2005, 99(2): Camicioli, R., Kryscio, R. Nature throws curve-balls: Apolipoprotien E and nonlinear decline in Alzheimer disease. Invited editorial, Neurology, 2005, 65(12): Patchell R.A., Tibbs P.A., Regine W.F., Payne R., Saris S., Kryscio R.J., Mohiuddin M., Young B. Direct decompressive surgical resection in the treatment of spinal cord

343 Kryscio 13 compression caused by metastatic cancer: a randomized trial. Lancet, 2005, 366: Markesbery WR, Kryscio RJ, Lovell MA, Morrow JD. Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Ann Neurol. 2005, 58(5): Dietrich CS 3 rd, Modesitt SC, DePriest PD, Ueland FR Wilder J, Reedy MB, Pavlik EJ, Cibull M, Giesler J, Manahan K, Huh W, Cohn D, Powell M, Slomovitz B, Higgins RV, Merritt W, Hunter J, Puls L, Gehrig P, van Nagell JR Jr.The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC). Gynecol Oncol. 2005, 99(3): Markesbery W.R., Schmitt F.A., Kryscio R.J., Davis D.G., Smith C.D., Wekstein, D.R. The neuropathologic substrate of mild cognitive impairment. Archives of Neurology, 2006, 63(1): Greenberg R.N., I. Raad I., Anstead G., Herbrecht R.,, Langston A.,. Marr K.A., Mullane K., Schiller G.,, M., Schuster M.,, van Burik J., Wingard J.R.,, Gonzalez C.E., Revankar S.G., Corcoran, G., Kryscio R.J.,Hare R. Posaconazole as Salvage Therapy for Zygomycosis. Antimicrobial Agents & Chemotherapy, 2006, 50(1): Thrall M., Gallion H.H., Kryscio R., Kapali M., Armstrong D.K., DeLoia, J.A. BRCA1 expression in a large series of sporadic ovarian carcinomas: a Gynecologic Oncology Group study. Int. J. Gyn. Cancer, 2006,16 (Suppl 1): Miller, C.S., King C.P. Jr., Langub, M.C., Kryscio, R.J., Thomas, M. Salivary biomarkers of existing periodontal disease: a cross sectional study. Journal Amer Dental Assoc. 2006, 137(3): Espinosa PS, Kryscio RJ, Mendiondo MS, Schmitt FA, Wekstein DR, Markesbery WR, Smith CD Alzheimer s disease and head circumference J Alzheimer s Dis. 2006, 9(1): French JA, Kryscio RJ Active control trials for epilepsy: avoiding bias in head-tohead trials. Invited editorial. Neurology 2006, 66(9): Berger JR, Miller CS, Mootoor Y, Avdiushko SA, Kryscio RJ, Zhu H JC virus detection in bodily fluids: clues to transmission. Clin Infect Dis 2006, 43(1): Miller CS, Berger JR, Mootoor Y, Avdiushko SA, Zhu H, Kryscio RJ. High prevalence of multiple human herpesviruses in saliva from human immunodeficiency virus-infected persons in the era of highly active antiretroviral therapy. J Clin Microbiol. 2006, 44(7): Caban-Holt A, Schmitt, F.A., Runyons C.R., Kryscio, R.J. Mendiondo, M.S. Sundquist, M.S., Markesbery, W.R., Coltman, C.A. Crowley, J.J., Goodman, P., Hartline, J.A. Studying the effects of vitamin E and selenium for Alzheimer s disease prevention: the PREADVISE model. Research and Practice in Alzheimer s Disease

344 Kryscio 14 and Cognitive Decline. In: B Vellas LF, H Feldman, E Giacobini, M Grundman, B Winblad, A. Kurz (ed) Research and Practice in Alzheimer's Disease. Carma Publishing, vol 11, pp in press, Damiano D., Abel M, Romness M, Oeffinger D, Tylkowski C, Gorton G, Bagley A, Nicholson D, Barnes D, Calmes J, Kryscio R, Rogers S Comparing functional profiles of children with hemiplegic and diplegic cerebral palsy in GMFMCS Levels I and II: are separate classifications needed? Dev Med Child Neurol 2006, 48(1): Kryscio RJ, Schmitt FA, Salazar JC, Mendiondo MS, Markesbery, WR. Risk factors for transitions from normal to mild cognitive impairment and dementia Neurology 2006, 66(6): Andrykowski M, Zhang M, Pavlik E J, Kryscio R J Factors associated with return for routine annual screening in an ovarian cancer screening program Gyn Oncology, 104: , Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio RJ, Chebrolu H, Walton A, Wagner R, Young AB Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson s disease: response to 1 year each of treatment and withdrawal. J Neurosurgery, to appear, Kryscio, RJ, Schmitt, FA., Mendiondo, M.S., Markesbery, W.R. Hypertension as a risk factor for transitions from normal to dementia and mild cognitive impairment. Research and Practice in Alzheimer s disease and cognitive Disorders. To appear Vol 10, 2007 Tyas S L, Salazar J C, Snowdon D A, Desrosiers M F, Riley K P, Mendiondo, M S, Kryscio R J Transitions to mild cognitive impairment, dementia and death: findings from the NUN study. Am. J. Epidemiology, to appear, 2007 PRESENTATIONS Category A: Invited Identifying risk factors for mild cognitive impairment and dementia using Markov transition models. Biostatistics Department, SUNY, Buffalo, November 30, Estimating the relative risk of cases to controls on the line with large samples using nearest neighbor statistics. Int. Workshop Applied Probability. U Connecticut, May 15, Risk factors for transitions to MCI and dementia: findings from the NUN study. General lecture. Medical College of Wisconsin, April 5, Statistical properties of transition models with absorbing states Division of Biostatistics, Medical College of Wisconsin, April 4, Risk factors for transitions from normal to mild cognitive impairment and dementia. Washington University, St. Louis, November 1, 2005.

345 Kryscio 15 Design and Analysis Issues in Prevention Trials. Drug Information Association 41st Annual Meeting, June 28, Design and analysis issues in pharmacy studies. St Joseph s Hospital, Lexington,July, 2005 Alzheimer s 101: nuts and bolts of longitudinal data analysis. Alzheimer s Disease Research Center, University of Kentucky, March 2, 2005 Multi-state random effects models with application to a longitudinal study of transitions to dementia. Cleveland Clinic, Feb. 25, Risk Factors for MCI and Dementia. 3 rd Longitudinal Conference on Aging. Radisson Hotel, Lexington, Ky., December, Design issues in public health trials. Invited presentation to Statistics Club, Eastern Kentucky University, November, Issues in longitudinal data analysis and the advantages of mixed effects model regression formulation. Missing data imputation. Psychometrics Workshop. University of Washington Friday Harbor Conference Center, September, PREADVISE: A simple, large Alzheimer s disease prevention trial. Roswell Park Cancer Institute, May, Identifying disease clusters in non-uniform populations by using a computationally efficient k nearest neighbor procedure. Fourth Biannual International Conference on Statistics, Probability and Related Areas, Northern Illinois University. June, 2002 (with D. Pavlov). Designing a large prevention trial: statistical issues. Second conference on Statistical Methodology in AD Research. May, 2002 (with M. Mendiondo and F. Schmitt). Interpreting clinical trial results: what we often forget to mention in the protocol. Kentucky Center of Clinical Research and Investigative Services (KCRISS). January, Clinical trials Beyond Advanced Placement Statistics Workshop. University of Kentucky. November, A quality clinical trial recipe: mix good patient care, data management, and biostatistics. Kentucky Center for Clinical Research and Investigator Services. January 17, Statistics as part of an Alzheimer s disease research center. Kentucky Chapter of the American Statistical Association. December 4, 2000 (with M. Mendiondo). Statistics as part of a large clinical research training program. Joint Statistical Meetings, Baltimore, Maryland, August 10, 1999 (with J. Clive). From punched cards to desktop SAS. SAS Users Group, Lexington, Ky., November 21, A comparison of space-time clustering statistics. First Northern Illinois University Symposium on Statistical Science, DeKalb, Illinois, September 27, Statistics in action: A Kentucky experience. Mathematics Awareness Week, Eastern Kentucky University, April 22, 1996.

346 Kryscio 16 Bioengineering and statistics: a fruitful collaboration. Center for Biomedical Engineering, University of Kentucky, February 27, From bench to brain: developing drugs for Alzheimer s disease. Invited participant, Workshop at Sanders Brown Center on Aging, March 15, Sampling frames and sample design. Invited presentation. The Tobacco Regulation Technical Assistance workshop. Baltimore, Maryland, February 29, Outcome evaluation: paired county and baseline comparisons. Appalachian Leadership Initiation on Cancer. Lexington, Kentucky, May 2, Cancer Cluster Study. Calvert City Advisory Committee Meeting, May 11, Where the jobs are, 1995: professional opportunities in Biostatistics. Invited discussant. American Statistical Association Meetings, Orlando, August 15, Detecting space-time clustering using cell count data. American Statistical Association Annual Meetings, Toronto, August 17, Statistical aspect of clinical research. Tenth Annual Symposium on Mathematics, Statistics, and Computer Science. Eastern Kentucky University, March 4, Some computational problems in modeling epidemics. Epidemiological Modeling Workshop, Pittsburgh Supercomputing Center, December 3, Measuring the severity of clustering using Tango s Index. Workshop: Epidemic modeling and data analysis, Skokloster, Sweden, August 11, Use of stochastic epidemic theory to model the AIDS epidemic SRCOS/ASA Summer Research Conference in Statistics, June 11, On the extinction of the S-I-S stochastic logistic epidemic. Mini-conference on epidemic modeling. Statistics and Applied Probability Program, University of California, Santa Barbara, April 22, On modeling the incidence of AIDS. Conference on stochastic processes in epidemic theory, Marseilles, France, October 24-28, On modeling the incidence of AIDS: work in progress. Department of Radiation Medicine, Wayne State University, March 17, Designing clinical trials at a small institution. Department of Radiation Medicine, Wayne State University, March 17, The analysis of repeated measures experiments International Minerals Corporation, Terre Haute, Indiana, May 14, Double sampling plans with two applications ASQC, Wabash Valley Chapter, May 14, Pitfalls in the analysis of biomedical data. Division of Cardiology Colloquium Series, College of Medicine, University of Kentucky, October 10, Clinical trials: Principles versus practice. International Neutron Therapy Workshop, April 24, 1985.

347 Kryscio 17 Two-stage sampling plans with an application. ASQC, Lexington Chapter, November 14, Models for the shattering of particles (with W.S. Griffith and P. Purdue). American Statistical Association Annual Meetings, August, On modeling venereal disease epidemics. ORSA/TIMS Special Interest Meeting in Applied Probability, June, A probability model for predicting the impact of changes in the EPA compliance standard for sulphur emissions on the coal resources of Eastern Kentucky (with J.C. Cobb, J.C. Currens and K.W. Teoh). Workshop on Acid Rain in Kentucky, May 3, Modeling spatial patterns and tests for randomness (with R. Saunders). Buffalo-Niagara Chapter of the American Statistical Association, April, A maximum likelihood procedure for Chen s property tax model. Department of Statistics Colloquium Series, SUNY at Buffalo, March, Computational and estimation procedures in multidimensional right-shift processes. American Statistical Association Annual Meetings, August, Category B: Contributed: Surveillance of occupational drivers using k nearest neighbor methods on the line (with Svetla Slavova presenter).. Joint Statistical Meetings, Seattle, Aug, Effect of antioxidant use at baseline on transitions from normal to MCI and dementia (with M Mendiondo, F Schmitt, X Zhang, A Caban-Holt) Poster presentation, Joint Statistical Meetings, Seattle, August, Parametric estimation in the presence of censored data (with Sergey Tarima - presenter). JSM, Minneapolis, August, The distribution of the product of correlated P values with application to sequence homology searches (with Yan Xie) Poster presentation, JSM, Minneapolis, August, Modeling clinical change from normal aging to MCI, dementia, and death (with F.A. Schmitt, M.S. Mendiondo, L.Yu) Alzheimer s Association 9 th International Meeting, Washington, D.C., June, Shared random effects analysis of multi-state Markov models: application to the NUN Study. (JC Salazar, SL Tyas, MF Desrosiers, KP Riley, MS Mendiondo, DA Snowdon) JSM, Toronto, August, Discriminating usual cognitive aging form Alzheimer s disease: a statistical and normative approach to the CERAD cognitive assessment (with JC Salazar, DG Davis, MS Mendiondo, WR Markesbery and FA Schmitt) World Congress on AD, Philadelphia, July, 2004 Risk factors for mild cognitive impairments and conversion to dementia: findings from the Nun Study. World Congress on AD, August, 2002 (with S. Tyas, D. Snowdon, K. Riley, M. Desrosiers, M. Mendiondo and W. Markesbery). Designing a brief Alzheimer screen. Second conference on Statistical Methodology in AD Research, May, 2002 (with M. Mendiondo, F. Schmitt and W. Ashford).

348 Kryscio 18 A new computationally efficient clustering technique of k nearest neighbor type. JSM, Atlanta, 2001 (with D. Pavlov). Mixed models for correlating cognitive decline with severity of dementia at autopsy. JSM, Atlanta, 2001 (with M. Mendiondo, F. Schmitt, D. Davis, D. Wekstein and W. Markesbery). Mixed models for correlating cognitive decline with severity of dementia at autopsy. Joint Statistical Meetings, Atlanta, August 2001 (with M.S. Mendiondo*, F. Schmitt, D. Davis, D. Wekstein, and W. Markesbery). A new computationally efficient clustering technique of k nearest neighbor type. Joint Statistical Meetings. Atlanta, August 2001 (with D. Pavlov). Identifying disease clusters in populations with non-uniform density by k nearest neighbor model: Joint Statistical Meetings, Indianapolis, August, 2000 (with D. Pavlov). Optimality of the maximum cell count in cluster detection. Joint Statistical Meetings, Indianapolis, August, 2000 (with L. Kay and C.L. Wood). Predicting cognitive decline in Alzheimer s disease. Poster presentation: Joint Statistical Meetings, Baltimore, Maryland, August 11, 1999 (with M.S. Mendiondo and J.W. Ashford). Components of chi-square statistics for detecting space-time disease clustering (with G.C. Cline), Joint Statistical Meetings, Anaheim, August 10, On computing the Ederer-Meyers-Mantel statistic. American Statistical Association Annual Meetings, August, A note on Tango s index of clustering. Biometrics Society, ENAR Spring Meetings, March, Measuring the severity of disease clustering. Eastern Regional Meetings of the Biometrics Society, March, A stochastic model for the incidence of AIDS. International Biometrics Conference, Namur, Belgium, July 19, A note on tests for randomness in sparse spatial patterns (with R. Saunders and G. Funk). Eastern Regional Meetings of the Institute of Mathematical Statistics, March, Asymptotic multivariate distributions for arrays of binary variables II: the normal case (with R. Saunders and G. Funk). American Statistical Association Annual Meetings, August, Asymptotic multivariate distributions for arrays of binary variables I: the Poisson case. Central Regional Meetings of the Institute of Mathematical Statistics, June, Estimation for carrier-borne epidemics (with R. Saunders). Western Regional Meetings of the Biometrics Society, June, Solutions to the forward equations of Gart s epidemic model. NSF Conference on the Mathematical Theories of Population, August, The transition probabilities of a bounded bivariate pure death process. Central Regional Meetings of the Institute of Mathematical Statistics, June, 1974.

349 Kryscio 19 On the extended simple stochastic epidemic model. Eastern Regional Meeting of the Biometrics Society, June, EXTRAMURAL GRANT SUPPORT: Category A: Basic Research: Models and statistical techniques for clustering. National Science Foundation, May, 1979 to November, 1981 (with G.M. Funk and R. Saunders). Probabilistic modeling and inferential problems with applications to engineering and medicine. Component project 4 of the Kentucky EPSCoR program, NSF (P.I. W.S. Griffith) October, 1986 to September, Epidemic theory for an infectious disease of the S-I-S type, January, 1988 to December, NATO (travel grant for international collaboration with C. Lefevre of University of Brussels). Statistical methodology in Alzheimer s disease research (conference grant). May 15, 1997 to April 30, National Institute on Aging and National Institute on Neurological Diseases and Stroke. Minority Supplement, Program Project Grant: Brain oxidation in the pathogenesis of Alzheimer s disease (salary and travel support for a postdoctoral appointment in biostatistics: Dr. Marta Mendiondo). July 1, 1998 April 30, National Institute on Aging. Statistical Methodology in Alzheimer s Disease Research (2 nd conference grant). February, 2002 January, National Institute on Aging. Category B: Consulting: Cervix cancer cf-252 neutron therapy. American Cancer Society, January, 1983 to December, 1986 (Y. Maruyama, P.I.) A national collegiate survey on eating attitudes and behavior. League of Women Voters, August, 1985 to June, 1986 (L. Humphries, P.I.). Monoclonal antibodies in the treatment of kidney graft rejection. National Institute of Health, August, 1985 to July, 1988 (J. Thompson, P.I.). Field survey of adult women in Eastern Kentucky, State of Kentucky and Center for Disease Control, Atlanta, January, 1986 to June, 1986 (Philip Roeder, P.I.). Smokeless tobacco use among Kentucky youth: a feasibility study. National Cancer Institute, September, 1986 to August, 1987 (Melody Powers Noland, P.I.) Rural adolescent family life: health and well being, January, 1988 to March, 1989, Office of Adolescent Pregnancy Programs (Sarah Quandt, P.I.). Neutron interstitial brachytherapy using californium-252 and beam radiation for the treatment of large localized hemisphere malignant glioma. October, 1987 to October, 1991, National Cancer Institute, (Roy Patchell, P.I.).

350 Kryscio 20 Single-mother families: predictors of health outcomes. September, 1988 to February, National Institutes of Health (Lynne A. Hall, P.I.). Clinical trials for use of monoclonal antibodies in the prevention of kidney graft rejection. July, 1988 to June, 1992, National Institutes of Allergic and Infectious Diseases (John Thompson, P.I.). Nutritional strategies and dietary status of rural elderly. May, 1989 to April, 1991, National Institute on Aging (Sarah Quandt, P.I.). Respiratory afferents in the control of breathing. April, 1989 to March, 1994, National Heart, Lung and Blood Institute (Donald Frazier, P.I.). High-tech home care for children with chronic health conditions. October, 1989 to September, 1991, Maternal and Child Health Program (Juanita Fleming, P.I.). Alzheimer s Disease Research Center. August, 1990 to July, National Institute on Aging (William Markesbery, P.I.). Farm family health and hazard surveillance. October, 1990 to September, National Institute of Occupational Safety and Health / Center for Disease Control (Robert McKnight, P.I.). Alzheimer s disease, dental amalgams, and mercury. September, 1991 to June, National Institute on Aging (William Markesbery, P.I.). General clinical research center. December, 1991 to November, National Clinical Research (Emery Wilson, P.I.). Prevention of tobacco use among high-risk adolescents. May, 1992 to April, National Cancer Institute (Melody Noland Powers, P.I.). Surgery for spinal cord compression due to cancer. August, 1991 to July, National Cancer Institute (Roy Patchell, P.I.). The impact of specialty on cesarean section rates. April, 1992 to September, ANCPR (William Hueston, P.I.). Calcium regulation in brain aging and Alzheimer s disease. July, 1992 to June, National Institute on Aging (Phillip Landfield, P.I.) Central highlands Appalachia leadership on cancer. September, 1991 to September, National Cancer Institute (Gil Friedell, P.I.). Southeast Center for Agricultural Health and Injury Prevention. September, 1992 to September, Center for Disease Control and National Institute on Occupational Health and Safety (Robert McKnight, P.I.). Mechanisms of brain injury and its systemic sequela. April, 1994 to March, National Institute on Neurological Diseases and Stroke (B. Young, P.I.). Drug use by dentists and dental students: prevalence and use in the workplace. September, 1994 to August, National Institute on Drug Abuse (R.B. Clayton, P.I.). Breakdown of amalgam margins: a microstructural study. June, 1992 to May, National Institute of Dental Research (Richard J. Mitchell, P.I.).

351 Kryscio 21 AIDS prevention for drug injectors in Kentucky. June, 1993 to May, National Institute of Drug Abuse (Carl Leukefild, P.I.). Trial of predictive algorithm to transplant high PRA patients. August, 1995 to July, National Heart, Lung and Blood Institute (John Thompson, P.I.). Statistical analysis of groundwater monitoring data. February, 1995 to June, Natural Resources and Environmental Protection Cabinet, Kentucky (Richard Kryscio, P.I.). Respiratory afferents in the control of breathing. February, 1995 to November, National Heart, Lung and Blood Institute (Donald Frazier, P.I.). Alzheimer s Disease Research Center. May, 1995 to june, National Institute on Aging (William Markesbery, P.I.).Core B: Biostatistics and Data Management (Richard Kryscio, P.I.). Aging of central dopaminergic systems in primates. December, 1996 to November, National Institute on Aging (Don Gash, P.I.). Brain oxidation in the pathogenesis of Alzheimer s disease. December, 1996 to November, National Institute on Aging (William Markesbery, P.I.). General Clinical Research Center. December, 1996 to November, National Clinical Research (Emery Wilson, P.I.). Statistical analysis of HIV/AIDS policy and educational assessment survey. July, 1997 to October, Kentucky Department of Education (Richard Kryscio, P.I.). Statistical analysis of HIV/AIDS policy and educational assessment survey. August, 1998 to November, Kentucky Department of Education (Richard Kryscio, P.I.). Detection of presymptomatic Alzheimer s disease with fmri. October, 1997 to September, National Institute on Aging and National Institute on Neurological Diseases and Stroke (Charles Smith, P.I.). Restoration of dopamine function in Parkinson s disease. September, 1999 to August, National Institute of Neurological Diseases and Stroke (Greg Gerhardt, P.I.). Assessing the burden of colorectal cancer. September, 1999 to August, Centers for Disease Control. (Claudia Hopenhayn-Rich, P.I.). Ovarian cancer screening: psychobehavioral outcomes. March, 2000 to February, National Cancer Institute (Michael Andrykowski, P.I.). MRI probes of BBB integrity HIV dementia. NGA. September, 2000 to August, (Malcolm Avisom, P.I.). MR predictors of response to HAART in HIV dementia. NGA. September, 2000 to August, (Joseph Berger, P.I.). Dosing and safety of CsA for treatment of severe head injury. August, 2001 to July, 2005 (Byron Young, P.I.).

352 Kryscio 22 Prevention of Alzheimer s disease by Vitamin E and Selenium. October, 2001 to September, 2006 (William Markesbery, P.I.). General Clinical Research Center. May, 2002 April, 2006 (Emory Wilson, P.I.). National Center for Research Resources. Detection of presymptomatic Alzheimer s Disease by fmri. December, 2002 November, 2007 (Charles Smith, P.I.). National Institute on Aging. Autologous Dendritic Cell Vaccines in NSCLC April, 2004 March, (Edward A. Hirschowitz, PI) National Cancer Institute Screening for ovarian cancer: psychobehavioral outcomes. September, 2004 to August, 2008 (Michael Andrykowski,, P.I.) National Cancer Institute Safety and Operational Impacts of Design Element Trade-Offs July, 2004 January, 2007 (Nikiforos Stamatiadis, PI) Department of Transportation Career training in therapeutics and translational research. September, 2000 August, 2006 (Steve Shedlofsky, P.I.). National Center for Research Resources. Early treatment of ALS with nutrition and NIPPV. August, 2004 December, (Edward Kasarskis, P.I.) National Institute on Neurological Diseases and Stroke. Center for the biologic basis of oral/systemic diseases (CBBOSD). October 2004 May, (Jeffrey Ebersole, P.I.) National Center for Research Resources, COBRE grant. Center of Biomedical Research in Excellence for Women's Health (COBRE-WH) September, April, (Thomas Curry, P.I.) National Center for Research Resources. Neuroimaging studies of depression in Parkinson s disease (Lee Blonder, P.I.) National Institute of Mental Health July 2006 June The role of NSMase-2 in Aging (Mariana-Karashian, P.I.) National Institute on Aging August 2006-July, Alzheimer s Disease Center (William Markesbery, P.I.) National Institute on Aging, July June Core B: Biostatistics and Data Management Core (Richard Kryscio, P.I.) TEACHING EXPERIENCE: Courses Taught: Statistical Inference, Introduction to Probability, Regression Analysis, Multivariate Methods, Design and Analysis of Experiments, Applied Probability Models, Introduction to Stochastic Processes, Sampling Techniques, Consulting Statistics, Clinical Trials Design and Methodology, Biostatistical Methods I, Biostatistical Methods II, Proseminar in Biostatistics, Advanced Data Analysis, Design and Analysis of Health Surveys. Departmental nominee for a University-wide Excellence in Teaching Award, Department of Mathematical Sciences, Northern Illinois University, 1978.

353 Kryscio 23 SELECTED UNIVERSITY SERVICE: Promotion and Tenure Academic Area Advisory Committees: Dean s Level: College of Arts and Sciences, (Chair, ) College of Public Health 2006-present University Level: Physical and Engineering Sciences, Scientific Advisory Committees at U.K.: General Clinical Research Center, 1985 present; Markey Cancer Center, , and 1993 present; Tobacco and Health Research Institute, (Chair, 1998); Survey Research Center, ; College of Medicine Grant Reviews, ; Chair, Safety and Monitoring Committee, IGF-1 plus growth factor therapy for head trauma clinical trial, Chair, Safety and Monitoring Committee, Cyclosporine for head trauma: Phase I study, Chancellor s (Medical Center) Committee on Scientific Integrity, Academic Council for the Medical Center: University Senate Liaison, University Research Professorship Selection Committee: University Research Advisory Committee: Doctoral Thesis Advisor: Dr. James Booth, Professor, Program in Statistics, Cornell University. J. Gani, co-director Dr. Kerry Barker, 1988, Biostatistical Manager, Searle R&D Dr. Mary Kay Rayens, 1992, Associate Professor, College of Nursing, University of Kentucky, Chandler Medical Center Dr. Patrick Peterson, 1995, Biostatistician, Eli Lilly Dr. Gary C. Cline, 1997, Biostatistician, Proctor and Gamble Dr. Lisa Whitis Kay, 1997, Assistant Professor, Department of Mathematics, Statistics, and Computer Science, Eastern Kentucky University Dr. Cameron T. Alsup, 2000, Biostatistician, Merck Research Laboratories Dr. Dmitri Pavlov, 2001, Biostatistician, Pfizer Dr. Xuejing Peng, 2003, Research Assistant Professor, Cleveland Clinic, Arnold Stromberg, codirector Dr. Juan Carlos Salazar, Associate Professor, National University of Columbia Dr. Sergey Tarima, 2005, Assistant Professor, Medical College of Wisconsin

354 Kryscio 24 Post Doctoral Advisor: Dr. Marta Mendiondo, Currently an Assistant Professor, Department of Biostatistics, College of Public Health, University of Kentucky MEMBERSHIPS: American Statistical Association: Elected, Chair, Academic Representatives Session, Joint Statistical Meetings, 1999 Biometrics Society: Member, Regional Advisory Board of ENAR, SIGMA XI: President of Northern Illinois University Chapter, Southern Regional Committee on Statistics (SRCOS): Program Chair, Summer Research Conference, 1995 Kentucky Chapter of the American Statistical Association: Vice President, President, co-chair, Special Awards Judging in Statistics, International Science and Engineering Science Fair, Louisville, May 12-13, 1997 Statistics Program Representatives Meeting: program chair (elected) Joint Statistical Meetings, Baltimore, Maryland, August 10, 1999 Memberships on invited review panels: Special emphasis panels for the National Institute on Aging: Healthy aging and senile dementia, Washington University, St. Louis, October, 1997 Alzheimer s Disease Data Coordinating Center, Bethesda, Maryland, December, 1998 Claude Pepper Centers Review Team, Bethesda, Maryland, March, 1999 Member, site review team: University of Maryland, Baltimore, May, 1999 Case Western Reserve University, May, 1999 Claude Pepper Centers Review Team, Bethesda, Maryland, November, 2000 Alzheimer s Disease Centers Review Team, January, 2001 Healthy aging and senile dementia, Washington University, St. Louis, October, 1997 Age related changes of cognition in health and disease, Bethesda, MD, March, 2002 Resource Centers and Coordinating Centers for Minority Aging Research, Bethesda, MD, June, Study section in Alzheimer s Disease, Bethesda, MD, February, 2003 Healthy aging and senile dementia, Bethesda, MD, March, 2003 Alzheimer s Disease Centers Review Team, Bethesda, Md., Sept., and Oct., 2003 Adult children study, Bethesda. Md.. March Fronto temporal dementia PPG from UCSF, October, 2006 Substitute member, NAME Study Section, March 2007 Special emphasis panel for National Institute on Neurological Diseases and Stroke. Statistics Coordinating Center for Parkinson s Disease Clinical Trials, August, 2001 Special emphasis panel for National Center for Complementary and Alternative Medicine, April, 2003 Special Emphasis Panel: Antimicrobial Resistance research CDC, Atlanta, May 10, 2006

355 Kryscio 25 Member, Steering Committee, National Alzheimer s Coordinating Center, Member, External Advisory Committee, Alzheimer s Disease Research Center, University of Washington, Seattle, Guest editor: special issue, Statistics in Medicine on Statistical Methodology in Alzheimer s Disease Research. Vol. 19, Nos. 11 & 12, June 2000 (with F. Schmitt). Member, Committee on Experimental Medicine, Gynecologic Oncology Group (GOG), 2001-present Moderator, Controversies in Clinical Trials Design Workshop, GOG Summer Symposium, Vancouver, B.C., July, 2002 Member, Data Safety Monitoring Committee. AmSMART Project, Texas Scottish Rite Hospital for Children, Dallas, TX, 2002-present Member, Data Safety Monitoring Board, Alzheimer s Disease Cooperative Studies Group, present Member, Advisory Board in Alzheimer s Disease, Sanofi-Synthelabo Inc., 2002-present Member, External Advisory Board, Einstein Aging Study, Albert Einstein College of Medicine, 2003-present Guest Editor: special issue of Statistics in Medicine on Statistical Methodology in Alzheimer s Disease Research, II. (with F. Schmitt) Vol. 23, No. 2, January, 2004 (with F. Schmitt) Associate Editor, Neurology, February, present Member: Scientific Review Committee, National Alzheimer s Disease Coordinating Center, January 2005 present. Member, External Advisory Board, Alzheimer s Disease Research Center, University of Michigan 2006-present Awards Fellow, American Statistical Association, 1995 Chapter Service Award, Kentucky Chapter of the American Statistical Association, 2000 Paul Minton Award for outstanding service to statistical education and the profession, Southern Region Council on Statistics (SRCOS), September, University Research Professor, University of Kentucky, Last updated: 4/17/2007

356 Dr. Richard J. Charnigo, Jr. Curriculum Vitae December 2007 Basic Information Contact Information Mail: 1. College of Public Health 203-B 2. Patterson Office Tower 851 University of Kentucky University of Kentucky Lexington, KY Lexington, KY Phone: x and Internet: Employment Assistant Professor 2004-present University of Kentucky Department of Biostatistics (College of Public Health) Department of Statistics (College of Arts and Sciences) Assistant Professor University of Kentucky Department of Statistics (College of Arts and Sciences) Division of Biostatistics (School of Public Health) Education Ph.D. in Statistics Case Western Reserve University Dissertation: Testing Homogeneity in Finite Mixtures and a Semi-Local Paradigm for Wavelet Denoising Advisor: Jiayang Sun M.S. in Mathematics Case Western Reserve University B.S. in Mathematics Case Western Reserve University Minor fields: Statistics and Economics Research Interests, Publications, and Presentations Research Interests Theory and methods for mixture modeling Theory and methods for nonparametric regression and functional data analysis Applications in cardiology, psychology, engineering, organizational behavior, and public health

357 Publications 1. Smith, Toni; Charnigo, Richard (2002). On the Nonoptimality of the Compensation System in Major League Baseball. Compensation and Working Conditions: Volume 6, pp Charnigo, Richard; Sun, Jiayang (2004). Testing for Homogeneity in Mixture Distributions via the L 2 Distance Between Competing Models. Journal of the American Statistical Association: Volume 99, pp Steinhubl, Steven; Charnigo, Richard; Moliterno, David (2005). Resistance to antiplatelet resistance: is it justified? Journal of the American College of Cardiology: Volume 45, pp Charnigo, Richard; Sun, Jiayang; Muzic, Raymond (2006). A Semi-Local Paradigm for Wavelet Denoising. IEEE Transactions on Image Processing: Volume 15, pp Steinhubl, Steven; Charnigo, Richard (2006). Clopidogrel Pretreatment Prior to Percutaneous Coronary Intervention: When Enough Isn t Enough. Journal of the American Medical Association: Volume 295, pp Barisione, Chiara; Charnigo, Richard; Howatt, Deborah; Moorleghen, Jessica; Rateri, Debra; Daugherty, Alan (2006). Rapid Dilation of the Abdominal Aorta During Infusion of Angiotensin II Detected by Noninvasive High Frequency Ultrasound. Journal of Vascular Surgery: Volume 44, pp Das, Pranab; Moliterno, David; Charnigo, Richard; Mukherjee, Debabrata; Sneed, Darell; Steinhubl, Steven; Booth, David; Ziada, Khaled (2006). Impact of Drug-Eluting Stents on Outcomes of Patients with End-Stage Renal Disease Undergoing Percutaneous Coronary Revascularization. Journal of Invasive Cardiology: Volume 18, pp Tackett, Julie; Charnigo, Richard; Caldwell, Glyn (2006). Relating West Nile Virus Case Fatality Rates to Demographic and Surveillance Variables. Public Health Reports: Volume 121, pp John, Vijay; Dai, Hongying; Talati, Ajay; Charnigo, Richard; Neuman, Michael; Bada, Henrietta (2007). Autonomic Alterations in Cocaine-Exposed Neonates following Orthostatic Stress. Pediatric Research: Volume 61, pp Charnigo, Richard; Pilla, Ramani S. (2007). Semiparametric Mixtures of Generalized Exponential Families. Scandinavian Journal of Statistics: Volume 34, pp Charnigo, Richard; Francoeur, Mathieu; Mengüç, Pinar; Brock, Audrey; Leichter, Matthew; Srinivasan, Cidambi (2007). Derivatives of Scattering Profiles: Tools for Nanoparticle Characterization. Journal of the Optical Society of America A: Volume 24, pp Republished as the lead article in the Structural Properties section of Virtual Journal of Nanoscale Science and Technology: Volume 16, Issue 16, 15 Oct 2007.

358 12. Dai, Hongying; Charnigo, Richard (to appear). Omnibus Testing and Gene Filtration in Microarray Data Analysis. Journal of Applied Statistics. 13. Charnigo, Richard; Sun, Jiayang (to appear). Testing Homogeneity in Discrete Mixtures. Journal of Statistical Planning and Inference. 14. Steinhubl, Steven; Oh, Jennifer; Oestreich, Julie; Ferraris, Suellen; Nessel, Christopher; Schwabe, Kimberly; Charnigo, Richard; Akers, Wendell (to appear). Transitioning Patients from Cangrelor to Clopidogrel: Pharmacodynamic Evidence of a Competitive Interaction. Thrombosis Research. 15. Simmons, Leigh Ann; Braun, Bonnie; Charnigo, Richard; Havens, Jennifer; Wright, David (to appear). Depression and Poverty among Rural Women: a Relationship of Social Causation or Social Selection? Journal of Rural Health. 16. Dai, Hongying; Charnigo, Richard (to appear). Inferences in Contaminated Regression and Density Models. Sankhya. Works that have been submitted for publication 17. Lu, Hong; Rateri, Debra; Feldman, David; Charnigo, Richard; Cassis, Lisa; Daugherty, Alan. Renin Inhibition Reduces Hypercholesterolemia-induced Atherosclerosis: the Contribution of Renin from Bone Marrow-Derived Cells. Second revision invited by Journal of Clinical Investigation. 18. Pamuklar, Zehra; Lee, Jin; Cheng, Hsin-Yuan; Pantcharam, Manikandan; Charnigo, Richard; Steinhubl, Steven; Morris, Andrew; Smyth, Susan. Heterogenity of Platelet Lysophosphatidic Acid Responses and Their Association with Atherosclerotic Coronary Artery Disease. Second revision invited by Arteriosclerosis, Thrombosis, and Vascular Biology. 19. Crosby, Richard; DiClemente, Ralph; Charnigo, Richard; Snow, Gregory; Troutman, Adewale. A Brief, Clinic-Based, Safer Sex Intervention for African American Men at-risk of HIV Acquisition: A Randomized Controlled Trial. Revision invited by American Journal of Public Health. 20. Lynam, Donald; Charnigo, Richard; Caspi, Avshalom; Moffitt, Terrie; Raine, Adrian; Loeber, Rolf; Stouthamer-Loeber, Magda. The Stability of Psychopathy Across Adolescence. Revision invited by Journal of Abnormal Psychology. 21. Charnigo, Richard; Chesnut, Lorie W.; LoBianco, Tony; Kirby, Russell S. Thinking Outside the Curve, Part I: Modeling Birthweight Distribution and Fetal-Infant Mortality. 22. Charnigo, Richard; Srinivasan, Cidambi. Local and Global Analytic Curve Estimation. 23. Charnigo, Richard; Sun, Jiayang. Asymptotic Relationships between the D-Test and Likelihood Ratio-Type Tests for Homogeneity.

359 24. Chesnut, Lorie W.; Charnigo, Richard; LoBianco, Tony; Kirby, Russell S. Thinking Outside the Curve, Part II: Ideal Birthweights and Pediatric Paradoxes. 25. Dai, Hongying; Charnigo, Richard. Contaminated Normal Modeling with Application to Microarray Data Analysis. 26. Justice, Todd; Charnigo, Richard; Pate, Gordon. Epidemiologic Study of Heyde s Syndrome in High Shear Stress Cardiac Lesions. 27. Pilla, Ramani S.; Charnigo, Richard. Consistent Estimation and Model Selection in Semiparametric Mixtures. Presentations Flourishing or Floundering? Relief Pitching in Major League Baseball 1. Case Western Reserve University: Statistics Department colloquium (November 1999) 2. Case Western Reserve University: Statistics in American Daily Life (March 2000) 3. American Statistical Association: Cleveland chapter meeting (June 2000) 4. Society for American Baseball Research: Cleveland chapter meeting (July 2000) Testing for Homogeneity in Mixture Distributions via the L 2 Distance Between Competing Models 1. Case Western Reserve University: Workshop on Developments and Challenges in Mixture Models (June 2002 contributed poster) 2. Purdue University: International Symposium on Statistics (June 2003 invited) 3. American Statistical Association: Joint Statistical Meetings (August 2003 contributed) A Semi-Local Paradigm for Wavelet Denoising 1. University of Kentucky: Statistics Department colloquium (December 2002 invited) 2. Johns Hopkins University: Biostatistics Department colloquium (January 2003 invited) 3. Iowa State University: Statistics Department colloquium (January 2003 invited) 4. International Biometric Society: Spring meeting of the Eastern North American Region (April 2003 contributed) Testing for Homogeneity in Discrete Mixtures 1. American Statistical Association: Joint Statistical Meetings (August 2004 contributed) On a Flexible Information Criterion for Order Selection in Semiparametric Mixture Models 1. University of South Alabama: Mathematics and Statistics Department colloquium (November 2004 invited) 2. International Biometric Society: Spring meeting of the Eastern North American Region (March 2005 contributed) 3. Interface and Classification Society of North America: Joint annual meeting (June 2005 invited) 4. American Statistical Association: Joint Statistical Meetings (August 2005 invited) Local Analytic Curve Estimation 1. American Statistical Association: Joint Statistical Meetings (August 2006 contributed) 2. Case Western Reserve University: Statistics Department colloquium (October 2007 invited) Thinking Outside the Curve: Revisiting Birthweight Distribution 1. American Statistical Association: Kentucky chapter meeting (October 2006 invited) 2. American Statistical Association: Joint Statistical Meetings (August 2007 contributed) Inferences in Contaminated Density Models with Applications to Microarray Data Analysis 1. University of Alabama at Birmingham: Statistical Genetics Section (March 2007 invited)

360 External Funding (active) 1. DMS Charnigo (PI) 8/01/07 6/30/10, $250,000 NSF/DMS (1.0 month summer salary in FY08, FY09, 0.3 month summer salary in FY10) ESTIMATION OF ANALYTIC SURFACES WITH APPLICATIONS TO NANOPARTICLE CHARACTERIZATION VIA SURFACE WAVES This three-year project advances the statistical field of functional data analysis by rigorously developing a new compound estimation paradigm for simultaneously estimating a mean response and several of its derivatives from noisy data. Role: Principal Investigator 2. 1 R21 DA Martin (PI) 5/10/07 3/31/09, $400,000 NIH/NIDA (5% in FY08, 5% anticipated in FY09) MODAFINIL AND SMOKING CESSATION This project is a Phase II clinical trial exploring the efficacy of modafinil as a smoking cessation aid. If shown to be effective, modafinil could be added to the current pharmacotherapies for smoking cessation and may have particular benefit for female smokers for whom weight gain is a significant deterrent to smoking cessation. Role: Co-Investigator 3. Scutchfield (PI) 3/01/07 2/29/08, $110,000 National Network of Public Health Institutes (5% in FY08) NPHPSP DATA MINING This project seeks to identify factors that predict whether a public health department will excel in each of the ten essential public health services. Role: Statistical Consultant 4. 1K23HD A1 Reynolds (PI) 9/27/06 8/31/11, $540,000 NIH/CHHD (5% in FY07, FY08, > 5% anticipated through FY11) CERVICAL (NECK) AUSCULTATION AND DEVELOPMENTAL OUTCOMES This project is designed to relate cervical auscultation data acquired through digital signal processing technology (in particular, measurements of swallow-associated sounds during early rhythmic suckle feeding) to long-term neurologic and developmental outcomes. Role: Statistical Consultant 5. 1R01AI A1 Crosby (PI) 6/15/06 5/31/11, $2.9 million NIH/BSPH (2% in FY07, 5% in FY08, > 5% anticipated through FY11) DO CONDOMS PROTECT FROM NON-VIRAL SEXUALLY TRANSMITTED INFECTIONS? This project entails assessing condom effectiveness against chlamydia, trichomoniasis, and gonorrhea with particular attention to the moderating effects of gender and the losses in protective value associated with irregular and incorrect usage. Role: Co-Investigator 6. 1P01HL A1 Daugherty (PI) 4/08/06 3/31/11, $8.6 million NIH/HLBP (5% in FY07, FY08, 5% anticipated through FY11) MECHANISMS OF ABDOMINAL AORTIC ANEURYSM FORMATION This project is designed to provide mechanistic insight into the mechanisms involved in the initiation and propagation of abdominal aortic aneurysms. Role: Administrative Core 7. 5P50DA Bardo (PI) 9/30/92 6/30/12, $6.8 million for years 16 through 20 NIH/NIDA (10% in FY07, 0.9 month summer salary + 3% in FY08, 10% anticipated in FY09 through FY12) DRUG ABUSE PREVENTION - A LIFECOURSE PERSPECTIVE This project entails evaluations of school-based, curriculum-driven prevention programs with the evaluation of a comprehensive prevention program featuring both universal and selective high sensation value components. Role: Methodology and Statistics Core

361 External Funding (completed) 8. Charnigo (PI) 6/01/07 6/30/07, $2500 Naval Postgraduate School (0.2 month summer salary in FY07) PROFESSIONAL MORAL COURAGE AND MORAL DECISION MAKING This project involves the analysis of organizational behavior data pertaining to the Ethics in Action Research and Education program, with a particular focus on professional moral courage. Role: Principal Investigator 9. Charnigo (PI) 7/01/06 6/30/07, $8000 Naval Postgraduate School (6% in FY07) CONTRACT FOR STATISTICAL CONSULTING This project involves the analysis of organizational behavior data pertaining to the Ethics in Action Research and Education program, with a particular focus on curiosity and desired moral approbation. Role: Principal Investigator 10. Charnigo (PI) 3/01/05 8/31/05, $5700 Accumetrics, Inc. (0.5 month summer salary in FY06) CONTRACT FOR STATISTICAL CONSULTING This project involved the analysis of clinical data to ascertain variability in response to clopidogrel. Role: Principal Investigator 11. 1R21MH A1 Crosby (PI) 4/01/03 3/31/07, $450,000 NIH/NIMH (3% in FY06, 7% in FY07) PROMOTING HIV RISK REDUCTION IN AFRICAN AMERICAN MEN The goal of this study is to determine if a brief, clinic-based, intervention will enhance condom use among African American men diagnosed with an STD. Role: Statistical Consultant 12. 5R01MH Lynam (PI) 9/30/00 8/31/05, $790,000 NIH/NIMH (0.3 month summer salary in FY05) ADULT ANTISOCIAL OUTCOMES OF PSYCHOPATHIC CHILDREN The goals of this project included ascertaining the stability of psychopathy across development, the reliability of its assessment, and its value in predicting delinquency. Role: Statistical Consultant Internal Funding (active) Since 8/15/04, I have received support from the Division of Cardiology in the Department of Internal Medicine (20% in FY05, 20% of twelve-month salary in FY06, 30% of twelve-month salary in FY07, FY08, 30% of twelve-month salary anticipated in the foreseeable future; grant #6 above is subsumed into this support; twelve-month salary support is received both during the academic year and the summer, not necessarily at identical rates). My responsibilities have included collaborations and consultations with faculty, fellows, and research staff in Cardiology as well as statistical training for fellows in the form of an ongoing lecture series.

362 Teaching and Advising Teaching at the University of Kentucky CPH 931, Professional Seminar in Biostatistics (Spring 2007) [co-instructor with Richard Kryscio] This advanced course for Dr.P.H. students introduces sophisticated methods (e.g., weighted least squares, robust regression, ridge regression, nonparametric regression, polytomous regression, proportional odds regression, Poisson regression, and negative binomial regression) that can be employed when the methods introduced in CPH 930 do not apply. CPH 636, Data Mining in Public Health (Spring 2006) This is a graduate course whose topics include linear regression, logistic regression, discriminant analysis, regression and classification trees, neural networks, nearest neighbors methodology, factor analysis, and K-means clustering. STA 601, Theory of Statistical Inference II (Spring 2006, Spring 2007) This is a graduate course directed exclusively to students in Statistics. Topics include best unbiased estimators, uniformly most powerful tests, uniformly most accurate confidence sets, and standard asymptotic results for maximum likelihood estimators and likelihood ratio test statistics. STA 503, Introduction to Statistical Methods (Fall 2005, Fall 2006) This is a graduate course directed exclusively to students in Statistics. Topics include point and interval estimation, hypothesis testing, linear regression, logistic regression, and proportional hazards regression. CPH 739, Independent Study in Biostatistics (Fall 2005) I supervised Lorie Chesnut, an M.P.H. candidate concentrating in Epidemiology, on work that led to manuscript #24 above. STA 624, Applied Stochastic Processes (Spring 2005) This is a graduate course in stochastic processes directed primarily to students in Statistics but that draws students from some other departments as well. Topics include Markov chains in discrete time, Poisson processes, Markov chains in continuous time, and renewal processes. STA 715, Readings in Statistics: Topics in Mixture Modeling (Spring 2005) I supervised Hongying Dai, a Ph.D. Candidate in Statistics, on work that formed the basis for part of her dissertation on inference in contamination models. CPH 739, Independent Study in Biostatistics (Summer 2004) I supervised Julie Tackett, an M.P.H. candidate concentrating in Epidemiology, on work that led to manuscript #8 above. CPH 930, Advanced Biostatistical Methods in Public Health (Spring 2004, Fall 2004, Spring 2005, Fall 2006) This introductory course for Dr.P.H. students addresses linear regression, logistic regression, proportional hazards regression, and other topics relevant to students in public health. CPH 630/STA 681, Biostatistics II (Spring 2004, Fall 2004, Spring 2005 taught concurrently with CPH 930) This sequel to Biostatistics I addresses linear regression, logistic regression, proportional hazards regression, and other topics relevant to students in public health. STA 580, Biostatistics I (Fall 2003, Spring 2004, Fall 2007) This is a graduate course that addresses point and interval estimation, hypothesis testing, simple linear regression, and other topics relevant to students in public health.

363 Teaching at Case Western Reserve University STAT 312, Statistics for Engineering and Science (Fall 2001, Fall 2002) MATH 126, Mathematics II (Spring 1999) MATH 121, Calculus for Science and Engineering I (Fall 1997, Spring 1998, Fall 1998) Guest lectures on biostatistics given in other courses at the University of Kentucky OBI 650, Oral Biology for Postgraduate Dental Students (Fall 2004, Fall 2005, Fall 2006) MED 825, Introduction to Clinical Research (Spring 2004) Course development at the University of Kentucky CPH 636, Data Mining in Public Health (first offered in Spring 2006) This course, which Marta Mendiondo and I developed, addresses statistical techniques for and practical issues associated with the exploration of large public health data sets, the development of models from such data sets, and the effective communication of one's findings. CPH 633, Biometrics I (to be offered in Fall 2009) This course, which Heather Bush and I developed with input from our colleagues in Biostatistics, introduces probability, discrete random variables, continuous random variables, joint distributions, and sampling distributions. The course will emphasize probability principles as they relate to biostatistical methods and to applications in public health and allied fields. CPH 634, Biometrics II (to be offered in Spring 2010) This course, which Heather Bush and I developed with input from our colleagues in Biostatistics, introduces techniques for constructing and evaluating point estimators, hypothesis testing procedures, and interval estimators. The course will emphasize inferential principles as they relate to biostatistical methods and to applications in public health and allied fields. Advising at the University of Kentucky: current students 1. Dissertation committee member for Christopher Berger, Ph.D. Candidate (Exercise Science) 2. Capstone committee member for Sabrina Walsh, Dr.P.H. Candidate (Biostatistics) 3. Dissertation committee member for Joyce Robl, Ed.D. Candidate (Health Promotion) Advising at the University of Kentucky: former students 4. Capstone advisor for Alice Smith (M.P.H., Biostatistics, December 2007) 5. Dissertation committee member for Matthew Hersh (Ph.D., Statistics, December 2007) 6. Dissertation committee member for Rhonda VanDyke (Ph.D., Statistics, December 2007) 7. Capstone committee member for Torrie Harris (Dr.P.H., Health Behavior, August 2007) 8. Capstone committee member for Leo Gayheart (M.P.H., Epidemiology, August 2007) 9. Dissertation committee member for Mark Cullum (Ph.D., Exercise Science, August 2007) 10. Outside examiner for Andrea Milam (Ph.D., Instruction and Administration, August 2007) 11. Dissertation co-advisor (with Kert Viele) for Hongying Dai (Ph.D., Statistics, August 2006) Ms. Dai won the Statistics Department s 2006 R. L. Anderson award and the 2006 student paper competition of the American Statistical Association s Biopharmaceutical Section. She is now an Assistant Professor of Mathematics at Columbus State University in Georgia. 12. Capstone committee member for Lorie Chesnut (M.P.H., Epidemiology, December 2005) Ms. Chesnut won Second Prize in a competition for best abstract at the Twelfth Annual Maternal Child and Health Epidemiology Conference. The abstract and the talk that she gave were based on work initiated during her independent study with me. 13. Capstone committee member for Matin Katirai (M.P.H., Epidemiology, August 2005)

364 14. Capstone committee member for Jenny Olges (M.P.H., Epidemiology, August 2005) 15. Capstone committee member for Judy Stivers (M.P.H., Epidemiology, August 2005) 16. Capstone committee member for Julie Tackett (M.P.H., Epidemiology, August 2005) 17. Capstone committee member for Elizabeth Masterson (M.P.H., Epidemiology, May 2005) 18. Capstone committee member for Sophie Zhang (M.P.H., Epidemiology, May 2005) Service Professional (Conferences) Chair of To Mix or Not to Mix, an Invited Session at the March 2005 ENAR conference. Organizer and Chair of Mixture Modeling: Modern Approaches and Applications, an Invited Session at the May 2004 Interface conference. Professional (Refereeing) Referee for Statistica Sinica (twice in 2007) Referee for Canadian Journal of Statistics (2006, 2007) Referee for IEEE Transactions on Image Processing (twice in 2006) Referee for Journal of Statistical Planning and Inference (2005, twice in 2006) Referee for Journal of the American Statistical Association (2004, 2005, 2006) Referee for Journal of Statistical Computation and Simulation (2004) Professional (Written educational and outreach material) Gelman, Andrew; Carlin, John; Stern, Hal; Charnigo, Richard (2000, but since updated). Solutions to exercises from the book, Bayesian Data Analysis. Available to instructors via Charnigo, Richard (2001). Solutions Manual for Regression Analysis by Example. Available to instructors via Chesnut, Lorie; Charnigo, Richard; LoBianco, Tony (2006). Perinatal Periods of Risk: Mapping Feto-Infant Mortality in Kentucky. Kentucky Epidemiologic News and Reports: Volume 41, pp Professional (Training) Half-day seminar on logistic regression for Kentucky Department for Public Health personnel (2006) Guest lecture for Dietetic Interns at the University of Kentucky (2007) University of Kentucky (College level) College of Public Health Faculty Council (2005-present), Vice Chair ( ) College of Public Health Ad-Hoc Associate Dean Committee (2007) College of Public Health Research Committee ( ) College of Public Health Ad-Hoc Curriculum Committee (2006) College of Public Health (Staff) Employee of the Year Committee (2006) College of Public Health Academic Affairs Committee ( ) Judge, College of Public Health Research Symposium (2004, 2006) University of Kentucky (Department level) Statistics Department Ad-Hoc Degree Program Committee (2007-present) Biostatistics Department Ad-Hoc Degree Program Committee (2006-present) Statistics Department Grants/Contracts Committee (2006-present) Statistics Department M.S. Examination in Special Topics Committee (2006, 2007)

365 Statistics Department M.S. Examination in Probability Committee (2005) Biostatistics Department Dr.P.H. Examination in Biostatistics Committee (2004-present) Statistics Department Meeting Recorder ( ) Statistics Department M.S. Examination in Inference Committee (2004, 2006, 2007) Statistics Department Computing Committee (2003-present) Statistics Department Picnic Committee (2003-present) Case Western Reserve University (Graduate Student Senate) President ( ) Recording Secretary ( ) Verhosek Fund Appeal Committee ( , 2003) Activities Committee ( , 2002) Senator ( ) Case Western Reserve University (University level) Presidential Search Committee ( ) Faculty Senate General Assembly ( ) Commencement Speaker Committee ( ) Faculty Senate Graduate Studies Committee ( ) University Circle Incorporated Parking and Security Committee ( ) Miscellaneous Computing skills Proficient in both Windows and Unix environments Extensive experience with R, S-plus, SAS, and SPSS Familiarity with Fortran, Matlab, Mathematica, Maple, Enterprise Miner, and AMOS Other employment Regular keyboardist, St. Ladislas Parish in Westlake, Ohio (Summer 1990 to Fall 2002) Substitute keyboardist/vocalist, St. Gregory Parish in South Euclid, Ohio (Spring 2000) Professional musician and piano teacher (as opportunities have arisen) Proofreader, The Best Kept Secrets of Parma: The Garden City (Summer 1997) Awards/Honors Marquis Who s Who in the World (2008) Marquis Who s Who in Science and Engineering (2008) Marquis Who s Who in America (2007, 2008) Academic Keys Who s Who in Health Sciences Education (2006) Wethington Award (2006): College of Public Health (University of Kentucky) John Schoff Millis Award (1997): best academic record, College of Arts and Sciences (Case Western Reserve University) Max Morris Prize (1997) and Webster-Godman-Simon Award (1996): excellence in mathematics (Case Western Reserve University) Inducted into Phi Beta Kappa (1997) National Merit Scholarship ( ) Finalist, White House Commission of Presidential Scholars (1994) Rensselaer Medal (1993)

366 Present Position CURRICULUM VITA MARTA S. MENDIONDO, Ph.D. October 2007 Assistant Professor, Regular Title Series, College of Public Health, University of Kentucky Addresses Office Home 207 A Sanders-Brown Center on Aging 1359 Strawberry Lane 800 S. Limestone Lexington, KY University of Kentucky Telephone: (859) Telephone: (859) x274 marta@ .uky.edu Education Buenos Aires National University (UBA), Argentina Computador Cientifico [Computer Scientist], December 1971 Boston University, Massachusetts Masters of Applied Science: January 1977 Major Field: Computer Science University of Kentucky, Lexington, Kentucky Masters in Statistics: May 1990 PhD in Statistics: May 1997, Title: Approximation of Infinite-Dimensional Linear Programming Problems Professional Certifications ABR in Radiation Therapy: Board Certified in Therapeutic Radiological Physics, American College of Radiology, June Human Subjects Protection Education: ORI, University of Kentucky, May 2001 and CITI, November 2006 Professional Advancement American Statistical Association Continuing Education, Regression Graphics: Ideas for Studying Regressions through Graphs, course taken August SAS Institute, SAS Web Tools: Static and Dynamic Solutions Using SAS/IntrNet Software, course taken May 2000 Psychometric Workshop, Friday Harbour, WA. August 2004 Psychometric Workshop, Friday Harbour, WA. August 2005 Circles of Power, Women s Leadership Program, University of Kentucky, 2007 Research Interests My primary interest is the investigation of statistical methods for tracking longitudinal changes in neurodegenerative diseases such as dementia and ALS. This involves an emphasis on how clinical tools are used in the assessment of disease progression and how they model disease progression at differing stages of disease severity. Statistical approaches include studying the relationship between disease progression and clinical measures over time and the use of Markov models to model the changes between different stages of the disease. Current efforts are focused on a large dataset of normal (at baseline) older adults with the goal of applying these methods to detect clinically relevant decline. Some other interests include the applications of current statistical tools to the design and analysis of survey methods to collect sensitive data (e.g., elder abuse), developing statistical models of drug effects as well as health risks (e.g., antioxidants and rate of change in Alzheimer's disease), and the application of mixed models to the development of equations to better assess energy intake in ALS patients. Additionally, motivated by data collected in the ALS project and my role in the proposed CTSA grant I plan to work in the area of longitudinal data analysis applied to Quality of Life data and community projects. 1

367 Professional Experience Numerical Analyst, University of Buenos Aires, Argentina Teaching Assistant, Department of Mathematics. University of Buenos Aires, Argentina Instructor, Department of Mathematics. University of Buenos Aires, Argentina Radiation Dosimetrist, National Commission of Atomic Energy, Argentina Senior Radiation Dosimetrist, Massachusetts General Hospital, Boston Medical Physicist, Department of Radiation Medicine, University of Kentucky Medical Center 1982 Part-Time Instructor, Department of Mathematics, University of Kentucky Medical Physicist, Lexington Clinic, Lexington, Kentucky 1988 Statistics Consulting Lab, University of Kentucky Medical Physicist, Central Kentucky Radiation Oncology Center, Lexington, (part-time) 1991 Part-Time Instructor in Mathematics, Lexington Community College Teaching Assistant, Department of Statistics, University of Kentucky Project Statistician for the Kentucky Health Interview and Examination Survey (KHIES) 1993, Cabinet for Human Resources, Department for Health Services 1995 Full-Time Instructor in Statistics, University of Kentucky Teaching Assistant, Department of Statistics, University of Kentucky Postdoctoral Scholar, Biostatistics and Data Management Core, Alzheimer s Disease Research Center, Sanders-Brown Center on Aging, University of Kentucky 1998 Part-Time Instructor in Statistics, University of Kentucky Postdoctoral Scholar, Biostatistics, Program Project Grant: Brain Oxidation in the Pathogenesis of AD (partially supported by minority supplement) Sanders-Brown Center on Aging, University of Kentucky 2000 Part-Time Instructor in Statistics, University of Kentucky Statistician and Data Manager (Scientist III), Sanders-Brown Center on Aging, University of Kentucky Assistant Professor, Research Title Series, Kentucky School of Public Health, University of Kentucky Assistant Professor, Regular Title Series, College of Public Health, University of Kentucky Honors Wethington Award Wethington Award 2006 ASA Award for Outstanding Service and Leadership 2

368 RESEARCH PUBLICATIONS Articles in Refereed Journals 1. Goitein, M., Wittenberg, Mendiondo, M., et al. (1979). The value of CT Scanning in Radiation Therapy Treatment Planning: A Prospective Study. Int. Journal of Radiation Oncology Biol. Phys. Vol. 5, Coffey, C.W., Beach, J.L., Thompson, D., Mendiondo, M.S. (1980). X-ray Beam Characteristics of the Varian Clinac Linear Accelerator. Medical Physics, Vol.7, Beach, J.L., Mendiondo, M.S., & Mendiondo, O.A. (1987). A comparison of air-cavity inhomogeneity effects for cobalt-60, 6- and 10-MV x-ray beams. Medical Physics, Vol 14, Beach, J.L., Mendiondo, M.S., & Blue, J.W. (1993). Air Cavity Perturbation of a Clinical p(42)be Neutron Beam. Medical Physics, Vol 20, Mendiondo, M.S. & Stockbridge, R.H. (1998). Approximating Linear Programming Problems which arise in Stochastic Control. Proceedings of the 37 th Conference on Decision and Control, Tampa, Florida, December, Mendiondo, M.S. & Stockbridge, R.H. (1998). Approximation of Infinite-Dimensional Linear Programming Problems which arise in Stochastic Control. SIAM Journal on Control and Optimization, Vol. 36, Mendiondo, M.S., Schmitt, F.A., Ashford, J.W., & Kryscio, R.J. Modeling Mental Status Changes Using the CERAD Data. Statistics in Medicine, Vol 19, , Mendiondo, M.S., Ashford, J.W., Kryscio, R.J., Schmitt, F.A. (2000). Modeling mini mental state examination changes in Alzheimer s disease. Stat Med, 19(11-12), Ashford, J.W., Shih, W.J., Coupal, J.J., Shetty, R., Aleem, A., Stipp, V., Mendiondo, M.S., & Schmitt, F.A. (2000). Single SPECT measures of Cerebral Cortical Blood Flow Reflect Time Index Estimation of Dementia Severity in Alzheimer s Disease. Journal of Nuclear Medicine, Vol 41, Mendiondo, M.S., Kryscio, R.J., & Schmitt, F.A. (2001). Models of progression in AD: Predicting disability and costs. Neurology, 57, Stockbridge, R.H. & Mendiondo, M.S. (2002). Long Term Average Cost with Cost Based on the Local Time of a Diffusion. Markov Processes and Controlled Markov Chains, Gaugler, J.E., Mendiondo, M.S., Smith, C.D., Schmitt, F.A. (2003). Secondary dementia caregiving and its consequences. American Journal of Alzheimer s Disease and Other Dementias, 18(5). 13. Mendiondo, M.S., Ashford, J.W., Kryscio, R.J., Schmitt, F.A. (2003). Designing a brief Alzheimer screen (BAS). Journal of Alzheimer s Disease, 5(5), Gaugler, J., Wackerbarth, S.B., Mendiondo, M., Schmitt, F.A., & Smith, C.D. (2003). The characteristics of dementia caregiving onset. American Journal of Alzheimer s Disease, 18(2), Kryscio, R.J., Mendiondo, M.S., Schmitt, F.A., Markesbery, W.R. (2004). Designing a large prevention trial: statistical issues. Statistics in Medicine, 23(2), Gaugler, J.E., Anderson, K.A., Leach, C.R., Smith, C.D., Schmitt, F.A., Mendiondo, M.S. (2004). The emotional ramifications of unmet need in dementia caregiving. American Journal of Alzheimer s Disease and Other Dementias, 19(6), Kasarskis, E.J, Dempsey-Hall, L., Malley Thompson, M., Chi Luu, L., Mendiondo, M., Kryscio, R. (2005). Rating the severity of ALS by caregivers over the telephone using the ALSFRS-R. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 6 (1), Gopalraj, R.K., Zhu, H., Kelly, J.F., Mendiondo, M.S., Pulliam, J.F., Bennett D.A., Estus, S. (2005). Genetic Association of low density lipoprotein receptor and Alzheimer s Disease. Neurobiology of Aging, 26, Small, G.W., Kaufer, D., Mendiondo, M.S., Quarg, P., Speigel, R. (2005). Cognitive performance in Alzheimer s disease patients receiving rivastigmine for up to 5 years. International Journal of Clinical Practice, 59(4), Kasarskis, E.J., Tandan, R., Mitsumoto, H., Simmons, Z., Bromberg, M., Matthews, D., Mendiondo, Kryscio, R. (2006). Modeling energy expenditure in ALS: A Prospective longitudinal study. Amyotrophic Lateral Sclerosis, 7 (Suppl 1), Swanberg, J.E., Kanatzar, T., Mendiondo, M.S., McCoskey, M. (2006). Caring for Our Elders: A Contemporary Conundrum for Working People. Families in Society, 87(3), Bottiggi, K.A., Salazar J.C., Yu, L., Caban-Holt, A., Ryan, M., Mendiondo, M.S., Schmitt, F.A. (2006). Long- Term Cognitive Impact of Anticholinergic Medications in Older Adults. American Journal of Geriatric Psychiatry, 14(11),

369 23. Kryscio, R.J., Schmitt, F.A., Salazar, J.C., Mendiondo, M.S., Markesbery, W.R. (2006). Risk factors for transitions from normal to mild cognitive impairment and dementia. Neurology, 66(6), Schmitt, F.A., Mendiondo, M.S., Kryscio, R.J., Ashford, J.W. (2006). A brief Alzheimer s Screen for Clinical Practice. Research and Practice in Alzheimer s Disease and Cognitive Decline, 11, Salazar, J.C., Schmitt, F.A., Yu, L., Mendiondo, M.S., Kryscio, R.J. (2006). Shared Random Effects Analysis of Multi-state Markov Models: Application to a Longitudinal Study of Transitions to Dementia. Statistics in Medicine, 26(3), Espinosa, P.S., Mendiondo, M.S., Kryscio, R.J., Smith, C.D., Wekstein, D., Markesbery, W.R., Schmitt, F.A. (2006). Alzheimer s Disease and Head Circumference. Journal of Alzheimer s Disease, 9(1), Caban-Holt, A., Mendiondo, M.S., Runyons, C.R., Kryscio, R.J., Markesbery, W., Schmitt, F.A. (2006). Cognitive Screening in the Antioxidant AD Prevention (PREADVISE) Trial: Concordance of MIS and CERAD. In Iqbal, K., Bengt, W., Avila, J. (Eds.), Alzheimer s Disease: New Advances (pp ). Bologna, Italy: Medimond. 28. Caban-Holt, A., Schmitt, F.A., Runyons, C.R., Kryscio, R.J., Mendiondo, M.S., Sundquist, M.S., et al. (2006). Studying the effects of Vitamin E and Selenium for Alzheimer s disease prevention. In Vellas, B., Fitten, L.J., Feldman, H., Giacobini, E., Grundman, M., Winblad, B., Kurz, A. (Eds), Research and Practice in Alzheimer s Disease and Cognitive Decline Volume 11 (pp ). Paris: Serdi. 29. Tyas, S.L., Salazar, J.C., Snowdon, D.A., Desrosiers, M.F., Riley, K.P., Mendiondo, M.S., Kryscio, R.J. (2007). Tyas et al. respond to predictors of rate change in disease progression. American Journal of Epidemiology, 165 (11), Tyas, S.L., Salazar, J.C., Snowdon, D.A., Desrosiers, M.F., Riley, K.P., Mendiondo, M.S., Kryscio, R.J. (2007). Transitions to mild cognitive impairments, dementia, and death: Findings from the Nun study. American Journal of Epidemiology, 165 (11), Kryscio, R.J., Schmitt, F.A., Mendiondo, M.S., Markesbery, W.R. (2007) Hypertension as a risk factor for transitions from normal to dementia or mild cognitive impairment. In Vellas, B., Fitten, L.J., Feldman, H., Giacobini, E., Grundman, M., Winblad, B., Kurz, A. (Eds), Research and Practice in Alzheimer s Disease and Cognitive Decline Volume 12 (pp ). Paris: Serdi 32. Ramsey-Klawsnik, H., Teaster, P.B., Mendiondo, M.S., Abner, E.L., Cecil, K.A., Tooms, M.R. (2007). Sexual abuse of vulnerable adults in care facilities: Clinical findings and a research initiative. Journal of the American Psychiatric Nurses Association, 12(6), Teaster, P.B., Ramsey-Klawsnik, H., Mendiondo, M.S., Abner, E.L., Cecil, K.A., Tooms, M.R. (In Press). From behind the shadows: A profile of sexual abuse of older men residing in nursing homes. Journal of Elder Abuse and Neglect. 34. Curd, P.R., Jessa, P., Mendiondo, M.S., Yu, L. (In Press). Do Rural Hospitals Promote Community Health as Much as their Urban Counterparts? Results of a Kentucky Hospital Survey. The Journal of Rural Health. 35. Nelson, P.T., Jicha, G.A., Schmitt, F.A., Liu, H., Davis, D.G., Mendiondo, M.S., Abner, E.L., Markesbery, W.R. (In Press). Clinicopathological Correlations in a Large Alzheimer s Disease Center Autopsy Cohort: Neuritic Plaques and Neurofibrillary Tangles Do Count when Staging Disease Severity. Journal of Neuropathology and Experimental Neurology. Technical Reports 1. Finger, R., Mendiondo, M.S., Stapleton, M., Spears, E. Kentucky Health Interview and Examination Survey. June Teaster, P.B., Wood, E.F., Karp, N., Laurence, S.A., Schmidt, W.C., Mendiondo, M.S. Wards of the State: A National Study of Public Guardianship. April Teaster, P.B., Otto, J.M., Dugar, T.D., Mendiondo, M.S., Abner, E.L., Cecil, K.A. The 2004 Survey of State Adult Protective Services: Abuse of Adults 60 Years of Age and Older. Report to the National Center on Elder Abuse, Administration on Aging, Washington, D.C Teaster, P.B., Dugar, T.D., Otto, J.M., Mendiondo, M.S. The 2004 Survey of State Adult Protective Services: Abuse of Vulnerable Adults. Report to the National Center on Elder Abuse, Administration on Aging, under review. 4

370 Manuscripts Under Review Abner, E.L., Mendiondo, M.S., Kryscio, R.J., Schmitt, F.A. Vitamin E and all-cause mortality: A meta-analysis of randomized, controlled trials. Submitted to Annals of Internal Medicine. Espinosa, P.S., Salazar J.C., Yu L., Mendiondo M. S., Robertson W.C., Baumann R.J. Lack of Valproic Acid Associated Weight Gain in Pre-Pubral Children. Submitted to Pediatric Neurology. Manuscripts in Preparation Espinosa, P. S, Espinosa, P.H., Mendiondo, M.S., Basantes, A.G., Abner, E. L., Schmitt, F.A., Velez, R.M., Jicha, J.A., Echeverría, G.A., Suárez, F. O., Galvin, J.E, Smith, C.D., Kryscio, R.J. Detecting Dementia in Ecuador Using the AD8 and CDR Evaluations. Love, M.M., Tyas, S.L., Fleming, S.T., Pearce, K.A., and the University of Kentucky Geriatric and Rural Interest Team (GRIT). Screening Mammography for Older Women: Barriers Primary Care Clinicians Want to Overcome and Successful Strategies They Recommend (A Kentucky Ambulatory Network Study). M. S. Mendiondo is the GRIT biostatistician. Mendiondo, M.S., Healey, M.L., Kasarskis, E.J., Kryscio, R.J., Stockburger, S., Xu, A. Relationship between accelerometer data and Bouchard Physical Activity Scale. Mendiondo, M.S., Teaster, P.B., Abner, E.L., Cecil, K.A., Marcum, J.S., Ramsey-Klawsnik, H. Outcomes of sexual abuse of vulnerable adults. Mendiondo, M.S., Abner, E.L., Kryscio, R.J., Grundman, M., Schmitt, F.A,. Risk factors for transitions from normal to mild cognitive impairment and dementia. Abstracts 1. Mendiondo, M.S., Ashford, A.W., Kryscio, R.J., Smith, C.D., Schmitt, F.A. (2002). A short clinic screening test for Alzheimer's disease. Neurobiol Aging 23:Suppl.1, Mendiondo, M.S. (2004) Discriminating usual cognitive aging from Alzheimer's disease: a statistical and normative approach to the CERAD cognitive assessment. Neurobiol Aging 25:Suppl.2, Kryscio, R.J., Salazar, J.C., Yu, L., Mendiondo, M.S., Schmitt, F.A. (2005). Modeling clinical change from normal aging to MCI, Dementia, and Death. Alzheimer Dement 1: Suppl. 1, S Runyons, C.R., Schmitt, F.A., Caban-Holt, A., Kryscio, R.J., Mendiondo, M.S., Markesbery, W.R. (2005). Antioxidants for the prevention of dementia. Overview of the PREADVISE trial. Alzheimer Dement 1: Suppl.1, S Schmitt, F.A., Mendiondo, M.S., Kryscio, R.J., Ashford, J.W. (2005) A brief Alzheimer s screen for use in clinical practice. Alzheimer Dement 1: Suppl. 1, S Mendiondo, M.S., Kryscio, R.J., Schmitt, F.A. Antioxidant use at enrollment predicts transitions from normal to amnestic MCI and dementia. 10 th International Conference on Alzheimer s Disease and Related Disorders, Madrid, Spain. July Bottiggi, K., Mendiondo, M., Mattingly, M., Smith, C., Cooper, G., Jicha, G., Schmitt, F.A. The influence of literacy of cognitive functioning in unimpaired older adults, mild cognitive impairment, and dementia. Epidemiology of Alzheimer s Disease Conference, University of San Diego, CA. April

371 GRANT SUPPORT (see Appendix I for details) 09/30/97 07/14/06 Alzheimer's Disease Research Center PI: William Markesbery, MD Agency: NIA 12/01/97 01/31/08 Oxidative Stress in Alzheimer's Disease PI: William Markesbery, MD Agency: NIA 05/01/99 04/30/00 PPG Minority Supplement PI: William Markesbery, MD Agency: NIA 09/30/01 08/31/08 Prevention of Alzheimer's Disease by Vitamin E and Selenium PI: William Markesbery, MD Agency: NIA 09/15/02 05/31/06 Urokinase-Type Plasminogen Activator and Alzheimers Disease PI: George Estus, PhD Agency: NIA 12/01/03 03/30/05 Wards of the State: A Study of Public Guardianship Programs in Seven Jurisdictions PI: Pamela Teaster, PhD Agency: Retirement Research Foundation 03/01/04 09/30/06 Understanding Elder Abuse: The 2004 National Survey of Adult Protective Service Administrators PI: Pamela Teaster, PhD Agency: NCPEA 04/15/04 03/31/08 The Sexual Abuse of Vulnerable Adults in Institutions PI: Pamela Teaster, PhD Agency: NIA 07/01/04 06/30/05 NACC Data Consortium PI: William Markesbery, MD Agency: University of Washington 08/01/04 11/30/07 Early Treatment of ALS with Nutrition and NIPPV PI: Edward Kasarskis, PhD Agency: NINDS 06/01/05 03/31/06 A Double-blind, Trial of TempurPedic vs. Standard Mattresses for Agitation in Alzheimer's Disease PI: Frederick Schmitt, PhD Agency: TempurPedic Medical Inc 07/01/05 06/30/06 African-American Churches' Role in Tobacco Norm Change: Innovative, Developmental, and Exploratory (IDEA) Grant PI: Linda Alexander, PhD Agency: Health Education Council 07/01/05 06/30/06 National Alzheimer's Coordinating Center (NACC) - Year 7 PI: William Markesbery Agency: University of Washington 07/01/06 06/30/07 National Alzheimer's Coordinating Center (NACC) - Year 8 PI: William Markesbery Agency: University of Washington 07/15/06 06/30/11 Alzheimer s Disease Core Center PI: William Markesbery, MD Agency: NIA 07/01/07 06/30/08 National Alzheimer's Coordinating Center (NACC) - Year 9 PI: William Markesbery, MD Agency: University of Washington 09/01/07 08/31/09 Telemedicine Assessment of Cognition in Rural Kentucky: the TACK Study PI: Gregory Jicha, MD Agency: Alzheimer s Association 09/01/07 08/31/09 A Week in the Life of Adult Protective Services PI: Pamela Teaster, PhD Agency: Kentucky Department for Families and Health 6

372 COURSES (Graduate =G, Undergraduate = U) TEACHING EXPERIENCE Department of Mathematics and Computer Science, University of Buenos Aires: Numerical Analysis (U) 1982 Department of Mathematics, University of Kentucky MA 108 Intermediate Algebra (U) 1991 Department of Mathematics, Lexington Community College MA 112 Trigonometry (U) , 2000 Department of Statistics, University of Kentucky STA 281 Probability and Statistics Using Interactive Computer Techniques (U) STA 291 Statistical Methods (U) STA 320 Introductory Probability (U) STA 322 Statistical Methods in Nonparametric Inference and Survey Sampling (U) STA 570 Basic Statistical Analysis (G) 2002 present College of Public Health, University of Kentucky STA 580 Biostatistics I (half semester covering for absent faculty) (G) CPH 535 Data Management and SAS Programming (G) CPH 631 Design and Analysis of Health Surveys (G) CPH 632 Mixed Models in Public Health (G) OTHER TEACHING ACTIVITIES Committees Masters/Capstone 2002 Davis Potter, Master of Public Health, Sampling Designs and the Behavioral Risk Factor Surveillance System 2003 Alisa Bowersock, Master of Public Health, Kentucky Adolescent Sexual Health Assessment: A Review of Kentucky's School Curricula and Health Outcomes," Committee Member 2004 Adwoa Boahene, Master of Public Health, "Food Security: Is Supermarket Access Associated with Pregnancy Outcome?," Committee Member 2004 Shulin Dong, Master of Public Health, The Role of Radiotherapy in Improving Survival in Patients with Small Cell Lung Cancer," Committee Member 2004 Rondeen Gordon, Master of Public Health, "Is Suicide More Likely in Older Adults with a Chronic Disease or Mental Illness?," Committee Member 2004 Mei Zhang, Master of Public Health, Factors Associated with TVS Screening Adherence, Committer Member 2006 Erin Abner, Master of Public Health, "Vitamin E and All-Cause Mortality: A Meta-Analysis of Randomized Controlled Trials", Chair. Submitted for publication, see under publications for details Fawwaz Al Aloul, Examination of the Validity of the Medical Outcome Study (MOS) Social Support Survey using Confirmatory Factor Analysis, Committee Member 2006 Carmen Saylor, Master of Public Health, "Analysis of Factors Related to Illegal Sales of Tobacco to Minors in Kentucky," Committee Member 2007 Andrew Kinch, Master of Public Health, Kentucky's Male AIDS Population: The Challenges Facing a Predominately Rural State," Committee Member 7

373 In progress In progress In progress In progress Doctoral In progress In progress In progress Capstone committee Chair for Margaret Healey Capstone Committee Member for T. J. Sugg, Capstone Committee Member for Maya Mc Doom Capstone Committee Member for Jay Covell Dissertation Committee Member for Svetla Slavova, Department of Statistics Dissertation Committee Member for Lei Yu, Department of Statistics Dissertation Committee Member for Myra Huffman, College of Education, Rehabilitation Sciences, Dr. Ph Student Advisor 2006 present Tiago Souza Fulbright Scholar Student Practicum Supervisor Erin Abner (with Dr. Richard Clayton) Carmen Saylor (with Dr. Pamela Teaster) Margaret Healey 2007 Louis J. Covell (with Dr. Edward Kasarskis) Research Assistant Supervisor Pamela Lancaster (M.S. Statistics) Rebecca D Angelo (M.S. Statistics) Matt Barker (PhD. Statistics) Juan Carlos Salazar (PhD. Statistics) Erin Abner (M.P.H.) 2005 Lei Yu Liou Xu (M.S. Statistics) 2006 present Jennifer Marcum (Dr. P.H.) Student Supervisor These students, while supported by collaborative grants, learn data management and statistical skills. T. J Sugg, Carmen Saylor Margaret Healey Robert Wells Jay Covell University Presentations Missing Data Seminar - Organized and presented half the lectures in a semester-long faculty seminar for the University of Kentucky Department of Statistics. Other lectures were presented by other faculty members of the department, Managing a Clinical Database Kryscio, R.J., Mendiondo, M.S.. Special Topics Forum presentation, UK Medical Center K30 Program, February,

374 PROFESSIONSAL DEVELOPMENT AND SERVICE DEPARTMENT, COLLEGE, AND UNIVERSITY SERVICE University of Kentucky Committees College of Public Health Admissions Committee Member, July 2002 July 2005 Self Study Committee Member, January 2003 December 2004 (This committee prepared the documentation for CEPH College accreditation.) By-Laws Committee Member, (This committee wrote the first by-laws for the College of Public Health.) Faculty Council (elected) Member, July 2003 July 2005 Ad-hoc IT Search Committee Member, By-Laws Committee Member, 2005 Research Committee Member, July 2005 July 2006 Employee of the Year Committee Member, October 2005 December 2005 Academic Affairs Committee Chair, July 2006 to present Ad-hoc Global Health Committee Member, July 2006 to present Ad-hoc MPH 42 Hour Committee Member, 2006 Ad-hoc Search Committee for Assistant Member, 2007 Dean of Students University (elected) Health Care Colleges Council Alternate, July 2005 July 2007 Health Care Colleges Council Member, July 2007 July 2009 University Senate Member, College of Public Health Conferences CPH Research Day Scientific Section Moderator, 2005 College of Public Health Research Day Co-Chair, 2006, 2007 OTHER PROFESSIONAL ACTIVITES. Professional Service Kentucky Chapter ASA Treasurer, First Statistical Methodology in Alzheimer s Disease Research Conference Steering Committee, 2000 International Science Fair Statistical Competition Chair and Judge, 2002 KARIS Executive Committee Member, Second Statistical Methodology in Alzheimer s Disease Research Conference Steering Committee, 2004 Data Safety Monitoring Board for HIV PI Effects on Macrophage Cholesterol (PI: Richard Greenberg) Member, 2004 Kentucky Chapter ASA Secretary, 2005 to present Professional Societies ASA (American Statistical Association) ENAR (International Biometric Society Eastern North American Region) APHA (American Public Health Association) ACR (American College of Radiology) 9

375 EDITORIAL SERVICES Editorships Journal of Alzheimer s Disease, 2003 Associate Editor Manuscript Review Journal of Elder Abuse and Neglect, 2007 STATISTICAL DATA ANALYSIS SOFTWARE SKILLS Expert SAS Programmer Experience using several statistical packages: SPSS, S-Plus, SUDAAN, CART, nquery and SOLAS 10

376 APPENDIX 1 - GRANT SUPPORT Alzheimer's Disease Research Center PI: William Markesbery, MD Agency: NIA 09/30/97 07/14/06 The aim of the present proposal is to acquire preliminary data on potential functional neuroanatomic markers of mild Alzheimer's disease (AD). We propose to compare functional activation patterns in approximately 25 mildly demented individuals and 25 carefully matched control subjects during the performance of episodic memory encoding and appropriate baseline tasks while functional magnetic resonance imaging (fmri) is performed. Region of interest (ROI) analyses will compare relative activation patterns in targeted frontal, and temporal lobe regions known to be involved in episodic memory encoding in normal individuals. In addition, whole-brain activation maps will be generated to explore potential differences in other regions. Potential differences in activation will be explored along lines of (1) magnitude; (2) spatial extent; and (3) temporal characteristics of hemodynamic response functions to examine potentially subtle differences in the timing of activation. Completion of this research will provide preliminary data concerning functional neuroanatomic changes accompanying episodic memory impairment in mild AD. In addition, the proposed project will serve as a foundation for the development of subsequent fmri paradigms intended to characterize subjects at risk, to differentiate normal age-related memory changes from prodromal dementia, and to monitor the effects of therapy as adjuncts to neuropsychological and clinical assessments. Oxidative Stress in Alzheimer's Disease PI: William Markesbery, MD Agency: NIA 12/01/97 01/31/08 Alzheimer's disease is a major health problem affecting 4 million persons in the USA. The key to understanding AD is determining the etiology and pathogenesis of neuron degeneration in specific brain regions. This application is for a five year renewal of the Program Project Grant (P01AG05119) at the University of Kentucky (UK) Sanders-Brown Center on Aging. The major goal of this program proje4ct is to gain an understanding of brain oxidation in AD. The program project is composed of two cores and four closely interrelated projects. Each project has human (AD and control), gene-altered animal and cell culture components. Each project has published and preliminary data relevant to specimens from longitudinally followed AD and control subjects that have short post-mortem interval autopsies. Project by Markesbery examines the hypothesis that oxidation of DNA and RNA oxidation. Project by Butterfield is aimed at defining the molecular mechanisms and sequela of Abeta-associated oxidative stress in AD. Special emphasis will be placed on the action of methionine in Abeta (1-42) in oxidative stress and neuron toxicity. Project by St. Clair examines the hypothesis that the ability of mitochondria to remove superoxide radicals without inflicting self injury plays a central role in regulating free radical mediated neurodegeneration in AD. This study will investigate the mechanism by which increased expression of manganese superoxide dismutase can be safely achieved in the brain. Project by Kindy is designed to understand the interaction between the receptor for advanced glycation endproducts, Abeta and oxidative stress. A coordination and administration Core will provide supervision and coordination of the research projects, financial management, statistical support, internal and external scientific review and procurement of tissue from the Uk ADRC. The Animal Core provides transgenic, knockout and knockin mice for all four projects. This program project has the potential of identifying molecular targets for development of therapeutic agents aimed at decreasing neuron injury and improving the outcome of AD. Prevention of Alzheimer's Disease by Vitamin E and Selenium PI: William Markesbery, MD Agency: NIA 09/30/01 08/31/08 DESCRIPTION: Alzheimer's disease (AD), is a major health problem in the United States, where it affects approximately four million older individuals. There is no effective treatment of AD and prevention is the key to this disorder. Oxidative stress, in the form of lipid, protein, carbohydrate and DNA oxidation plays a significant role in the pathogenesis of neuron degeneration in AD and serves as a potential therapeutic target for slowing the onset or preventing the disease. The present application, termed PREADVISE, is based on the hypothesis that early treatment with vitamin E and selenium (Se) in the presymptomatic stage of the disease may delay the onset or prevent AD. These two agents have strong antioxidant properties and have not been used together in a large human study. This proposed evaluation of AD prevention will be added to the Selenium and Vitamin E Chemoprevention Trial (SELECT), a NCI-supported, phase III, double-blind, placebo-controlled 2X2 factorial study that assesses the combined and single effect of these two antioxidants on the reduction of the incidence of prostate cancer in 32,400 healthy men 55 or older (50 or older if African American). The duration of SELECT will be 12 years with a five-year uniform accrual period. PREADVISE is open to men 65 or older (60 or older if a minority) and it is estimated that 10,368 participants will be enrolled. They will be randomized to one of four 11

377 arms: vitamin E plus Se, vitamin E plus Se placebo, Se plus vitamin E placebo, or vitamin E and Se placebos. They will undergo a memory impairment screening examination as part of the initial and annual SELECT evaluation, and those that fall below the cutoff point will undergo a more thorough cognitive evaluation using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery of cognitive tests. Participants who fail the CERAD battery will receive a thorough dementia medical evaluation for diagnosis and be reviewed in a consensus conference by neurologists and a neuropsychologist with lengthy experience in dementia. It is estimated that the relative risk for AD (relative risk 0.60) is detectable with 80 percent power in this trial. The study offers an inexpensive opportunity to evaluate the long-term effect of two antioxidant agents in slowing the onset or preventing AD in a large number of subjects. The study also will evaluate the sensitivity and specificity of the screening measure in a matched sample of normals. In addition, it will evaluate the effect of antioxidant therapy in a group of 200 elderly longitudinally followed normal controls. Urokinase-Type Plasminogen Activator and Alzheimers Disease PI: George Estus, PhD Agency: NIA 09/15/02 05/31/06 Genetic factors that contribute to Alzheimer's disease (AD) susceptibility are critical to our understanding and early diagnosis of the disease. A chromosome 10 region contains at least one susceptibility locus for late onset Alzheimer's disease, and is associated with increased amyloid-b (ADi) plasma levels. The gene encoding urokinase-type plasminogen activator (upa) is within this implicated region. UPA is induced by AB-treated neurons in vitro and in the Hsiao mouse model of AB burden in vivo. Moreover, upa converts plasminogen to the active protease plasmin, which degrades both nonaggregated and aggregated AB with physiologic efficiency. In summation, ADi induces upa, which can in turn lead to AB degradation, suggesting a selfregulated system for clearance of AB aggregates. Considering these data overall we hypothesize that the chromosome 10 loci includes a upa polymorphism(s) that modulates upa's ability to contribute to AD clearance. To evaluate this hypothesis, we propose to (i) identify upa polymorphisms that segregate with Alzheimer's disease. In preliminary work we have identified two upa polymorphisms that significantly segregate with AD susceptibility and are in strong linkage disequilibrium, including (i) a substitution of leu for pro at position 141 within upa, which alters binding of the upa zymogen to aggregated fibrin and (ii) a SNP two basepairs 3' to an AP-I site that is known to be critical for upa induction. We also propose to (ii) Gain insight into the possible role of the at-risk upa haplotype by comparing individuals homozygous for each genotype for relevant clinical and neuropathologic markers of Alzheimer's disease, (iii) Evaluate the effect of the upa polymorphisms associated with AD risk on upa expression and function, and (iv) Evaluate the role of upa in AB clearance in vivo by quantifying AB accumulation in mice that are wildtype or genetically deficient for upa. Overall, the focused approach proposed here will (i) directly evaluate the possible role of upa polymorphisms as a risk factor(s) for Alzheimer's disease, and (ii) provide insights into possible mechanisms underlying differential upa actions. These studies are significant in that the identification of additional genetic risk factors for Alzheimer's disease will aid in early AD diagnosis, and thereby facilitate drug discovery by identifying patients at high risk for AD prior to symptomology. Moreover, by evaluating possible mechanisms underlying the enhanced susceptibility to Alzheimer's disease, these studies may lead to the discovery of novel insights into the molecular mechanisms underlying Alzheimer's disease, and thereby suggest new therapeutic approaches. Wards of the State: A Study of Public Guardianship Programs in Seven Jurisdictions PI: Pamela Teaster, PhD Agency: Retirement Research Foundation 12/01/03 03/30/05 Understanding Elder Abuse: The 2004 National Survey of Adult Protective Service Administrators PI: Pamela Teaster, PhD Agency: National Committee Prevention of Elder Abuse 03/01/04 09/30/06 Mistreatment of older adults, including physical abuse, psychological, emotional, or mental abuse, material or financial exploitation, active neglect, passive neglect, and violation of civil rights is of growing national and international concern. Approximately 450,000 noninstitutionalized adults 60 years of age and older, or about 10 out of every 1,000 older persons living in the United States are victims of abuse. In the most recent and accurate study to date, the 2000 Survey of State Adult Protective Services indicated 472,813 reports of elder abuse (Teaster & Colleagues, 2003). Researchers and practitioners alike acknowledge that these estimates represent only the most overt cases, thus significantly underestimating the incidence of violence against elders living in long-term care facilities and in the community. The purpose of this project is to gather information on elder abuse during Fiscal Year 2003 from key Adult Protective Services (APS) supervisors throughout the 50 states, Washington, D.C. and Guam. The joint project, conducted with the National Association of Adult 12

378 Protective Services Administrators and the National Committee for the Prevention of Elder Abuse, will build on the survey conducted in The survey will focus on elder abuse specifically and will gather information on reports, investigations, substantiations, victims, perpetrators, and case outcomes concerning elder abuse in each state. To ensure reliability and validity of the data, a consultant, Marilyn Whalen, will review the data and make follow-up telephone or inquiries to clarify questionable data. Data analysis will include a variety of descriptive statistical methods, including means, frequency distributions, cross-tabulations, and plots. The resulting report will provide the most accurate picture of elder abuse in the nation as well as a reliable data set for use by researchers and practitioners. The Sexual Abuse of Vulnerable Adults in Institutions PI: Pamela Teaster, PhD Agency: NIA 04/15/04 03/31/08 In 2000, Adult Protective Services (APS). typically the state agency of first contact in cases of abuse, neglect, or exploitation, received 473,095 domestic (in the community) and institutional (nursing homes, assisted living, group homes) reports concerning vulnerable adults. Included in that number were 4,150 reports of sexual abuse, a number highly under-reported due to differing reporting categories and its taboo nature. Sexual abuse runs the gamut from kissing and fondling to forcible rape, and, validated by earlier studies, results in a diminished quality of life and, often, premature death. Because sexual abuse poses a significant public health and public safety problem requiring government intervention, this study is grounded in democratic governance theory, which emphasizes responsivity, representativeness. and responsibility through government intervention. The specific aims are: (1.) to investigate patterns of the sexual abuse of vulnerable older and younger adults living in long-term care institutions; (2.) to test a web-based system for obtaining sensitive and confidential information on the sexual abuse of vulnerable adults; and (3.) to refine an emergent theory of the mistreatment of vulnerable adults derived from democratic governance theory. This multi-state study focused on four states (New Hampshire, Oregon, Tennessee, and Texas) will utilize survey data provided by APS staff regarding all reports, reports investigated, and reports that were substantiated. Data collection will be undertaken using a web-based protocol. To check for reliability of survey data, the Pis and APS supervisors will conduct a clustered, randomized review of 20% of APS files. A randomized sample of 15% of APS staff will complete indepth telephone interviews regarding reports that were investigated only and reports substantiated. For nursing home residents only, data from resident's Minimum Data Set (MDS) will be collected six months prior to the report and six months after to provide a before and after picture of the resident who was sexually abused. To make comparisons about the types of facilities in which sexual abuse is occurring, the research team will use Nursing Home Compare, a Medicare website that provides public and facility specific information on all nursing homes receiving Medicare or Medicaid funds. We will analyze the data using descriptive statistics, Chi Squares, and logistic regression. This is the first systematic multi-state, theoretically grounded study to address the sexual abuse of vulnerable adults living in institutional settings. It will lay the foundation, for APS, law enforcement, health-related regulatory agencies, and the medical community for establishing investigatory protocols and intervention strategies as well as a for a model of prevention to address sexual abuse at local, state, and national levels. NACC Data Consortium PI: William Markesbery, MD Agency: University of Washington 07/01/04 06/30/05 The National Alzheimer's Coordinating Center (NACC), located at the University of Washington, is funded through a Cooperative Agreement (U01) with the National Institute on Aging. NACC's first funding cycle was , and the current application reflects the first year of a competing continuation for As part of the terms and conditions of their individual NIA awards, Alzheimer's Disease Centers (ADCs) are required to submit designated data to NACC to form a center-wide database. These data consist of, but are not limited to, a Minimum Data Set, a new and expanded Uniform Data Set (currently under development), neuropathology data, ancillary survey data, and meta data to describe individual ADC characteristics. These data form the basic level of participation necessary for all NIA-funded ADCs. To partially defray the costs associated with participating in this data-sharing effort and central database, NACC is authorized to provide some funding support to each ADC. This funding is intended to contribute to salary, equipment or supplies associated with the collection, preparation, and submission of data to NACC. The ADC may also participate in NACC-funded collaborative projects with other ADCs and, as a result, gain additional funds for specific projects; such descriptions and requirements will be added to the current scope of work. 13

379 Early Treatment of ALS with Nutrition and NIPPV PI: Edward Kasarskis, PhD Agency: NINDS 08/01/04 11/30/07 Studies to date indicate that Percutaneous Endoscopic Gastrostomy (PEG) and Non-Invasive Positive Pressure Ventilation (NIPPV) improve survival in Amyotrophic Lateral Sclerosis (ALS), even though introduced late in the disease. We hypothesize that early intervention may improve outcome even further. However, many issues regarding the early use of these treatments preclude the design of a Phase III clinical trial to test this hypothesis. Common to both NIPPV and nutrition is a lack of a reliable indicator of early respiratory or nutritional insufficiency. With respect to nutrition, we need reliable and cost effective methods to determine a patient's energy (i.e. caloric) requirements during different stages of the illness and base the recommendation for PEG on the adequacy of energy intake. For NIPPV, we need to identify factors that influence acceptance and tolerability of this therapy, and measurements of early respiratory dysfunction. Therefore, we propose this multicenter Pilot Study to develop methods for a definitive Phase III trial. The Specific Aims of this Pilot Study are: 1) To develop and validate strategies to improve tolerability of NIPPV, to identify factors that influence acceptance of this treatment modality, and to evaluate measures of early respiratory dysfunction; and 2) To develop and validate methods to determine energy balance in ALS. In this Pilot Study, all 11 sites will enroll patients using a stratified design based on FVC (80-95% vs 50-79%) and offer NIPPV as they decline to the lower limit of this FVC level. Six sites will collect additional detailed information to critically evaluate acceptability of NIPPV, devise strategies to improve tolerance, and validate this approach as well as collect respiratory measurements that may allow earlier identification of failure. The other 5 sites will use the "gold standard" Doubly Labeled Water method in a longitudinal design to derive empiric equations to reliably predict individual energy needs based on easily performed clinical measures. The results of this Pilot Study will allow us to develop and validate methods so that we can design a multicenter Phase III trial to determine the efficacy of early NIPPV and nutritional intervention. In addition, our results will be immediately applicable for use by clinicians in practice and will provide the basis to re-formulate the experimental design of future drug trials in ALS. A Double-blind, Trial of TempurPedic vs. Standard Mattresses for Agitation in Alzheimer's Disease PI: Frederick Schmitt, PhD Agency: TempurPedic Medical Inc 06/01/05 03/31/06 The purpose of this study was to compare the sleep pattern of moderate Alzheimer s Disease Patients using a new regular mattress and a TempurPedic mattress in Nursing Homes. African-American Churches' Role in Tobacco Norm Change: Innovative, Developmental, and Exploratory (IDEA) Grant PI: Linda Alexander, PhD Agency: Health Education Council 07/01/05 06/30/06 National Alzheimer's Coordinating Center (NACC) - Year 7 PI: William Markesbery Agency: University of Washington 07/01/05 06/30/06 The National Alzheimer's Coordinating Center (NACC), located at the University of Washington, has been funded through a Cooperative Agreement (U01 AG016976) with the National Institute on Aging since NACC collects and stores research data from Alzheimer's Disease Centers (ADCs) as mandated by NIA. The terms and conditions of NIA awards to the individual ADCs specify that they are required to submit designated limited research data to NACC for inclusion in the database. These data consist of, but are not limited to, a Minimum Data Set, a new and expanded Uniform Data Set, neuropathologic data, ancillary survey data, and meta data describing individual ADC characteristics (no subject names, addresses, etc. are included). These data form the basic level of participation required of all NIA-funded ADCs. To partially defray costs associated with participation in this data-sharing effort (e.g., salary, equipment or supplies required for the collection, preparation and submission of data), NACC is authorized to provide partial funding support to each ADC. This current application reflects Year 8 of the ongoing agreement and the third year of the budget cycle. The ADCs may also elect to participate in NACC-funded collaborative projects with other ADCs and, as a result, may gain additional funds for specific projects; such descriptions and requirements will be added to the current scope of work. National Alzheimer's Coordinating Center (NACC) - Year 8 PI: William Markesbery Agency: University of Washington 07/01/06 06/30/07 Direct Costs:?? (same as above) 14

380 Alzheimer s Disease Core Center PI: William Markesbery, MD Agency: NIA 07/15/06 06/30/11 This is a proposal for a 5-year Alzheimer's Disease Core Center (ADCC) at the University of Kentucky's Sanders-Brown Center on Aging. The application consists of the Administrative, Clinical, Biostatistics and Data Management, Neuropathology, Education and Information Transfer Cores, and two pilot projects. The UK ADC has developed a strong program in the clinical, neuropathological, educational and research aspects of AD that serves as a resource for the university, community, state, and region for the past twenty years. The major goals of the UK ADC are to: a) provide clinical data, serum, plasma, buffy coats and CSF from thoroughly evaluated, longitudinally followed, normal control subjects, AD and non-ad dementing disorders, and postmortem material from these subjects to investigators of AD and aging at UK and to national and international investigators, b) continue longitudinal investigation of presymptomatic AD, mild cognitive impairment, early AD, mixed dementias and other dementias, and normal brain aging with autopsy as an end point; c) develop new research initiatives and attract new investigators to research in neurodegeneration and aging; d) place emphasis on serving minorities and involving them in research; and e) participate in multicenter efforts, including NACC, ADCS, ADNI, and others. The Clinical Core will evaluate and longitudinally follow 500 subjects in the Normal Control (BRAiNS) Clinic and 200 patients with AD and other dementias in the Dementia Research Clinic - all with prearranged autopsies. This core will maintain a satellite clinic for African Americans in north Lexington in conjunction with an Administration on Aging grant for education of minorities about dementing disorders. The Neuropathology Core provides short postmortem interval brain specimens, CSF, and synaptosomes from longitudinally followed normal, MCI, early and late AD patients, and non-ad dementias to investigators and maintains a tissue bank. The Biostatistics and Data Management Core manages data sets from the other Cores, prepares the Uniform Data Set and the Minimum Data Set for submission to the NACC, and provides statistical design and analysis. The Education and Information Transfer Core assists with recruiting control and dementia subjects, provides research and clinical training for investigators and healthcare professionals, and disseminates information to the lay public. National Alzheimer's Coordinating Center (NACC) - Year 9 PI: William Markesbery, MD Agency: University of Washington 07/01/07 06/30/08 (same as above) Telemedicine Assessment of Cognition in Rural Kentucky: the TACK Study PI: Gregory Jicha, MD Agency: Alzheimer s Association 09/01/07 08/31/09 This project involves a randomized, blinded validation of a telemedicine cognitive evaluation protocol, development of telemedicine protocol for administering the National Alzheimer s Coordinating Center s Unified Dataset, and the establishment of a rural patient database. One week in the life of Adult Protective Services PI: Pamela Teaster, PhD Agency: KY Department for Families and Health 09/01/07 08/31/09 15

381 Adam J. Branscum Departments of Biostatistics, Statistics, and Epidemiology University of Kentucky 121 Washington Ave., Ste. 205B Lexington, KY Phone: Fax: EDUCATION Ph.D. Statistics 2005 University of California, Davis Department of Statistics M.S. Epidemiology 2005 University of California, Davis Graduate Group in Epidemiology M.S. Statistics 2000 California State University, East Bay Department of Statistics B.S. Mathematics 1999 California State University, East Bay Department of Mathematics and Computer Science EXPERIENCE Assistant Professor, University of Kentucky (August present). Department of Biostatistics (College of Public Health) Department of Statistics (College of Arts and Sciences) Department of Epidemiology (College of Public Health, August present) Assistant Statistician, Center for Animal Disease Modeling and Surveillance, University of California, Davis, School of Veterinary Medicine, Department of Medicine and Epidemiology ( ).

382 RESEARCH INTERESTS Bayesian nonparametric and semiparametric modeling and data analysis Biostatistics and epidemiologic modeling and applications Diagnostic test evaluation and disease prevalence estimation PUBLICATIONS 1. Branscum AJ, Gardner IA, Johnson WO (2004). Bayesian modeling of animal and herd-level prevalences. Preventive Veterinary Medicine 66, Hanson TE, Branscum AJ, Johnson WO (2005). Bayesian nonparametric modeling and data analysis: An introduction. In Bayesian Thinking: Modeling and Computation (Handbook of Statistics, Volume 25, Chapter 9), Edited by D.K. Dey and C.R. Rao. Amsterdam: Elsevier. 3. Branscum AJ, Gardner IA, Johnson WO (2005). Estimation of diagnostic test sensitivity and specificity through Bayesian modeling. Preventive Veterinary Medicine 68, Thurmond MC, Branscum AJ, Johnson WO, Bedrick EJ, Hanson TE (2005). Predicting the probability of abortion in dairy cows: a hierarchical Bayesian logisticsurvival model using sequential pregnancy data. Preventive Veterinary Medicine 68, Branscum AJ, Gardner IA, Wagner BW, McInturff P, Salman MD (2005). Effect of diagnostic testing error on intracluster correlation coefficient estimation. Preventive Veterinary Medicine 69, Branscum AJ, Johnson WO, Gardner IA (2006). Sample size calculations for disease freedom and prevalence estimation surveys. Statistics in Medicine 25, Reksen O, Sølverød L, Branscum AJ, Østeras O (2006). Relationships between milk culture results and treatment for clinical mastitis or culling in Norwegian dairy cattle. Journal of Dairy Science 89, Branscum AJ, Johnson WO, Gardner IA (2007). Sample size calculations for studies designed to evaluate diagnostic test accuracy. Journal of Agricultural, Biological, and Environmental Statistics 12,

383 9. Branscum AJ, Johnson WO, Thurmond MC (2007). Bayesian Beta Regression: Applications to Household Expenditure Data and Genetic Distance Between Footand-Mouth Disease Viruses. Australian & New Zealand Journal of Statistics 49(3), Cheng C, Stamey J, Branscum AJ (2007). A general approach to sample size determination for prevalence surveys that use dual test protocols. Biometrical Journal 49(5), Kelley GO, Garabed RB, Branscum A, Perez AM, Thurmond MC (2007). Prediction model for sequence variation of the glycoprotein gene of infectious hematopoietic necrosis virus in California, U.S.A. Diseases of Aquatic Organisms 78, Branscum AJ, Hanson TE. Bayesian nonparametric meta-analysis using Polya tree mixture models. Biometrics (to appear). 13. Hanson TE, Branscum AJ, Gardner IA. Multivariate mixtures of Polya trees for modeling ROC data. Statistical Modelling (accepted contribution to the special issue on Bayesian nonparametric modeling). 14. Branscum AJ, Hanson TE, Gardner IA. Bayesian nonparametric models for regional prevalence estimation. Journal of Applied Statistics (to appear). 15. Branscum AJ, Perez AM, Johnson WO, Thurmond MC. Bayesian spatiotemporal analysis of foot-and-mouth disease data from the Republic of Turkey. Epidemiology and Infection (to appear). 16. Hanson TE, Kottas A, Branscum AJ. Modeling stochastic order in the analysis of ROC data: Bayesian nonparametric approaches. Applied Statistics (to appear). 17. Messam L, Branscum AJ, Collins MT, Gardner IA. Frequentist and Bayesian approaches to prevalence estimation using examples from Johne s Disease. Animal Health Research Reviews (to appear). 18. Lu Z, Branscum A, Shuck KM, Zhang J, Dubovi E, Timoney PJ, Balasuriya U.B.R. Comparison of 2 real-time RT-PCR assays for the detection of equine arteritis virus nucleic acid in equine semen and tissue culture fluid. (in press to appear in Vol. 20, Number 2, March 2008, Journal of Veterinary Diagnostic Investigation). 19. Go Y-Y, Wong SJ, Branscum A, Demarest VL, Shuck KM, Vickers ML, Zhang J, McCollum WH, Timoney PJ, Balasuriya U.B.R. Development of a fluorescent microsphere immunoassay for detection of antibodies specific to equine arteritis virus and comparison with the virus neutralization test. Clinical and Vaccine Immunology (to appear).

384 SUBMITTED MANUSCRIPTS 1. Branscum AJ, Hanson TE, Gardner IA (2007). Multivariate ROC analysis using mixtures of Polya trees JSM Proceedings, Section on Bayesian Statistics [CD-ROM], Alexandria, VA: American Statistical Association: Paper ID Branscum AJ, Johnson WO, Hanson TE, Gardner IA. Bayesian semiparametric ROC curve estimation and disease diagnosis. (revision sent to Statistics in Medicine November 2007). 3. Romanelli F, Branscum A, Caldwell G, Thornton AC. Risk factors for community acquired methicillin resistant staphylococcal aureus (cmrsa) among a mixed urban-rural HIV infected population. (submitted to AIDS Patient Care and STDs June 2007.) 4. Johnson WO, Gardner IA, Metoyer CN, Branscum AJ. Insight into interpretation of test sensitivity estimates from latent class analyses based on one or two tests in single or multiple populations. (submitted to Preventive Veterinary Medicine July 2007). GRANTS 1. National Center for Research Resources Grant # P20 RR : Center for Biologic Basis of Oral/Systematic Diseases. This is a COBRE project emphasizing research training in oral health. A Biostatistics Core is funded. Total amount: $1,497,813 PI: Jeffrey Ebersole (University of Kentucky) Dates: August 2005 to present Role: Collaborator at 20% effort 2. Title: Optimization and evaluation of novel serum and milk enzyme-linked immunosorbent assays for Johne s disease PI: Adam Branscum and Shigetoshi Eda (University of Tennessee, Knoxville) Agency: USDA Total Amount: $293,000 Dates: August 2007 to July 2009 Role: Co-PI at 8.3% effort

385 3. Title: Mental healthiness aging initiative (MHAI), a community mental health aging educational intervention PI: Faika Zanjani and Deborah Murray (University of Kentucky) Agency: USDA Total Amount: $322,000 Dates: October 1, 2007 to September 30, 2008 Role: Collaborator at 3% effort 4. Title: Development of a hand-held diagnostic test for bovine tuberculosis PI: Shigetoshi Eda (University of Tennessee, Knoxville) Agency: Animal Health Board (New Zealand) Total Amount: $24,300 Dates: July 2007 to June 2008 Role: Collaborator 5. Title: Kentucky regional outreach and training consortium: A multi-county approach to blood-lead poisoning risk reduction in Kentucky s pediatric medicaid population. PI: Larry Figgs (University of Kentucky) Agency: EPA Total Amount: $249,750 Dates: September 1, 2007 to August 31, 2008 Role: Co-investigator at 5% effort INSTRUCTIONAL EXPERIENCE 1. Instructor, University of Kentucky, Departments of Biostatistics and Statistics: Theory of Statistical Inference I (STA 532: Fall 2007) Biostatistics I (STA 580: Fall 2006; Spring 2006, 2007) Biostatistics II (CPH 630/STA 681: Fall 2005, Spring 2006) Advanced Biostatistics Methods in Public Health (CPH 930: Spring 2007) 2. Guest lecturer, University of Kentucky, Department of Epidemiology: Advanced Epidemiology (CPH 712: Fall 2006 and Spring 2007, one week) Cancer Epidemiology (Spring 2007, one week)

386 TALKS AND WORKSHOPS 1. Joint Statistical Meetings 2007; Salt Lake City, Utah (topic contributed poster). 2. ENAR 2007; Atlanta, Georgia. 3. Joint Statistical Meetings 2006; Seattle, WA (invited). 4. International Biometric Conference 2006; Montreal, Quebec, Canada (invited). 5. The American Association of Veterinary Laboratory Diagnosticians. Invited speaker for the workshop on Sampling Methods for Detection of Disease, Minneapolis, MN; Texas A&M University, Department of Integrative Biosciences, University of California, Davis, Medical Center, Sacramento, California, Joint Statistical Meetings, Toronto, Canada, 2004 (topic contributed). 9. Statistics Research Day, California State University, Hayward, 2004 (Keynote speaker). 10. Conference of Research Workers in Animal Diseases, Chicago, Illinois, Workshop on Bayesian modeling and WinBUGS. University of California, Davis, Davis, California, May 9-10, 2003 (jointly with Wesley Johnson and Richard Evans) th Annual Institute on Research and Statistics, Sacramento Statistical Association, Sacramento, California, 2002 (invited). STUDENT COMMITTEES Member, College of Public Health, University of Kentucky, capstone committee. Current: Yuxia Wang (Chair), Dr. Mark Thomas, Krista Collard, Dana Manning, Mindy Sekhon, Dr. Johann Herberth, Leah Williams, Littron Cole, Abby Cosentino (DrPH), Joi Sherrod, Brittney Thomas. Completed: Amanda Wilburn (November 2007), Ashley McCarty (August 2007), Amanda Lewis (July 2007), Justin Blackburn (April 2007), Jennifer Methvin (April 2007), Jeff Covell (July 2006), Dr. Frank Romanelli (November 2006). Member, MS Committee, University of Kentucky:

387 Current: Megan McHugh (MS in Orthodontics), Tingting Wu (Department of Plant and Soil Science) Completed: Dr. Jim Zettler (MS in Orthodontics, Spring 2007) Member, PhD Committee, University of Kentucky: Current: Barry Meade (Department of Veterinary Science) Completed: Shuhua Lai (Department of Computer Science, October 2006). SERVICE Member, Protocol Review Committee, Markey Cancer Center, University of Kentucky (2007). Member, Research Committee, College of Public Health, University of Kentucky, 2007-present. Chair, Statistics department picnic committee, Fall Internal review of a USDA proposal entitled Precision Conservation With Geospatial Technologies, submitted by members of the College of Agriculture, University of Kentucky, Fall Member, MS inference exam committee, Department of Statistics (Summer 2007). Member, Undergraduate Program in Public Health committee, College of Public Health, University of Kentucky (Spring present). Member, Joint Biostatistics-Epidemiology Ph.D. committee, College of Public Health, University of Kentucky (Fall 2006-present). Member, Practice and Service Committee, College of Public Health, University of Kentucky, Ex-officio member, The Institutional Animal Care and Use Committee, University of Kentucky, 2005-present. Chair, DrPH biostatistics exam committee (June 2006). Chair, DrPH biostatistics exam committee (January 2008). Member, DrPH biostatistics exam committee (January and June 2007).

388 Biostatistics department representative, Public Health Initiative Retreat, University of Louisville (Fall 2006). Judge of presentations for the University of Kentucky College of Public Health Research Day (Fall 2006, 2007). Member, Consulting committee, Department of Statistics, University of Kentucky, 2006-present. Journal referee (2005): JASA, Biometrics, Veterinary Microbiology. Journal referee (2006): JASA, American Journal of Epidemiology, Annals of Epidemiology, Journal of Clinical Epidemiology, Veterinary Parasitology, Journal of Equine Veterinary Science, Preventive Veterinary Medicine. Journal referee (2007): JASA, The American Statistician PROFESSIONAL MEMBERSHIPS American Statistical Association International Biometric Society Institute of Mathematical Statistics International Society for Bayesian Analysis American Public Health Association

389 HEATHER M BUSH, PhD 121 Washington Avenue Room 205C Lexington, KY [email protected] Phone: EDUCATION 2006 Ph.D. in Statistics University of Kentucky Dissertation: Khatri-Rao products and conditions for the uniqueness of PARAFAC solutions for IxJxK arrays, Directed by William S Rayens 2001 M.S. in Statistics University of Kentucky 1999 B.S. in Mathematics Mount Vernon Nazarene University Summa Cum Laude Valedictorian PROFESSIONAL EXPERIENCE 08/06-present Assistant Professor Department of Biostatistics College of Public Health University of Kentucky 03/04-07/06 Sr. Statistician (Contractor from 03/04-07/05) REGISTRAT, Inc. 08/02-06/05 Research Assistant University of Kentucky, School of Public Health 08/99-08/02 Teaching Assistant University of Kentucky, Department of Statistics SERVICE Scientific Steering Committee, Centocor (10/07 present) University of Kentucky CPH Student Affairs and Admissions Committee (08/06 present) University of Kentucky CPH Security Taskforce (08/07 present) University of Kentucky CPH IT Advisory Council (08/07 present) Mt. Vernon Nazarene University Alumni Council (11/05 present) Graduate Student Representative, Department of Statistics (08/00 06/05) University of Kentucky New Teaching Assistant Orientation, Panel Member & Microteach Leader (2002) TEACHING CPH 630/STA 681 Biostatistics II (Fall 2006; Spring 2007; Fall 2007). Introductory course covering linear regression, logistic regression, proportional-hazards regression and other topics in statistical methods relevant to students in public health and clinical research. CPH 664 Design and Analysis of Clinical Trails (Fall 2006 with Dr. Kryscio). Introductory course in the fundamental concepts used in the design and analysis of Phase I-III clinical trials. CPH 632 Mixed Models in Public Health (Fall 2007) Introductory course in the statistical techniques for analyzing studies in public health that involve repeated measures and random effects.

390 CURRICULUM VITAE Heather M. Bush, PhD Page 2 ADVISING Capstone Committee member for Anthony Omojasola, DrPH Candidate, College of Public Health Capstone Committee member for Georgia Heise, DrPH Candidate, College of Public Health Capstone Committee member for Susannah Craig, MPH Candidate (finished Nov. 2006) Capstone Committee member for Travis Sizemore, MPH Candidate, College of Public Health Capstone Committee member for Dr. Diana Gascon, MPH Candidate (finished Jul. 2007) Capstone Committee member for Narender Reddygari, MPH Candidate, College of Public Health Capstone Committee member for Dr. Mark Casafrancisco, MPH Candidate (finished Jul. 2007) Capstone Committee member for Brandi Earp, MPH Candidate, College of Public Health Thesis Committee member for Dr. Albert Pascual, MS Candidate, College of Dentistry Thesis Committee member for Dr. Cheryl Widjeko, MS Candidate, College of Dentistry Thesis Committee member for Dr. Sally Holiday, MS Candidate, College of Dentistry Capstone Committee member for Rachel Hall, MPH Candidate, College of Public Health Capstone Committee member for Kovel Walker, MPH Candidate, College of Public Health Capstone Committee member for Kia Armstrong, MPH Candidate, College of Public Health Capstone Committee member for Malhar Jhaveri, MPH Candidate, College of Public Health Capstone Committee member for Sabrina Walsh, DrPH Candidate, College of Public Health FUNDING NCRR 5 P20 RR (Ebersole) 09/23/04 07/31/09 Center for Biologic Basis of Oral/Systematic Diseases This is a COBRE project emphasizing research training in oral health. A Biostatistics core is funded. CDC U17/CCU (Walsh) 09/01/04 08/31/09 Development of the National Violent Death Reporting System (2004) CDC U17CCU (Walsh) 09/01/06 08/01/07 Supplement to conduct surveillance of sudden unexplained infant deaths To conduct statewide surveillance of sudden unexplained infant deaths detailing the feasibility of collecting, abstracting, and coding SUID information to ultimately reduce these infant deaths. Information is currently being collected on Kentucky SUID deaths occurring in 2004 and 2005 Role: Statistical Faculty Advisor Research Triangle Institute (Clayton) 07/01/03 10/16/08 Tobacco Initiation and Cessation Among New Soldiers The main objective is to determine if differences exist in smoking and drinking by occupational specialty in the Army. Because there is a tendency in the military to house in the same facilities those studying the same occupational specialty, it is possible to examine the relationship of both individual-level and environmental-level influences on tobacco use. Role: Statistician Commonwealth of Kentucky Lung Cancer Research Program (Ferander) 09/01/07 08/31/09 Examining the Breathe Free for Women (BFFW) Program among African American (AA) Women: A Pilot Study The short-term objective of this study is to examine the effectiveness of the BFFW program among AA women. The long-term objective of this study is to improve smoking cessation intervention efficacy and decrease smoking among AA women, subsequently reducing disparate rates of lung cancer in this population. Role: Co-Investigator NIH/NCRR M01 RR (Perman) 04/01/06 03/31/07 General Clinic Research Center The mission of the UK General Clinical Research Center is to provide investigators with optimal

391 CURRICULUM VITAE Heather M. Bush, PhD Page 3 facilities and resources to conduct clinical research, to encourage collaboration among scientists, to train health care professionals in clinical research, and to aid in the translation of basic scientific knowledge into a better understanding and treatment of human diseases to advance the quality of patient care. Role: Statistician REGISTRAT, Inc. (Bush) 09/01/06 07/31/07 Provide statistical support on issues for product and disease registries and post-marketing commitments. Consult in the development of protocols, CRFs, biostatistical analysis plans and study reports. Prepare the statistical sections of manuscripts and abstracts for publications and scientific meetings. Role: PI PRESENTATIONS Khatri-Rao products and conditions for the uniqueness of PARAFAC solutions for I J K arrays, (by invitation) with William Rayens. Trilinear Methods in Chemistry and Psychology. Chania, Crete, June 2006, Bush presenting. Introduction to Biostatistics. Biomedical Research Undergraduate Training (BRUT) program, Transylvania University, July Patterns of Cervical Cancer Occurrence Among Appalachian Subgroups, with Claudia M. Hopenhayn, Amy Christian, Bin Huang. 18th National Conference on Chronic Disease Prevention and Control. Washington, D.C. February Hopenhayn presenting. Does Arsenic Exposure Increase the Risk of Anemia During Pregnancy, with Claudia M. Hopenhayn and Gilbert A. Boissonneault. International Society for Environmental Epidemiology 15 th Annual Conference. Perth, Australia. September Hopenhayn presenting. PAPERS AND REPORTS El-Chami MF, Hanna IR, Bush H, Langberg JJ. Impact of race and gender of cardiac device implantations. Heart Rhythm, 2007 Nov; 4(11): Epub 2007 Aug 1. Thomas KL, Al-Khatib SM, Kelsey RC 2nd, Bush H, Brosius L, Velazquez EJ, Peterson ED, Gilliam FR. Racial disparity in the utilization of implantable-cardioverter defibrillators among patients with prior myocardial infarction and an ejection fraction of </=35%. The American Journal of Cardiology, 2007 Sep; 100(6): Epub 2007 Jun 27. Hanna IR, Heeke B, Bush HM, Brosius L, King-Hageman D, Dudley SC Jr, Beshai JF, Langberg JJ. Lipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction. Heart Rhythm, 2006 Aug;3(8): Epub 2006 May 9. Hopenhayn, C., Bush, HM, G. Boisonneault, Peralta C, Bingcang A, Hertz-Picciotto I. Does Arsenic Exposure Increase Maternal Anemia During Pregnancy?. Journal of Occupational and Environmental Medicine, 2006 Jun;48(6): Hanna IR, Heeke B, Bush HM, Brosius L, King-Hageman D, Beshai JF, Langberg JJ. The Relationship Between Stature and the Prevalence of Atrial Fibrillation in Patients with Left Ventricular Dysfunction. JACC, 47(8):

392 CURRICULUM VITAE Heather M. Bush, PhD Page 4 Hopenhayn C, Bush HM, Christian A, Shelton B. Comparative analysis of invasive cervical cancer incidence rates in three Appalachian states. Preventive Medicine, 41(5-6): Christian A, Knight EA, Bush HM, and Anochie L. (2005) The Impact of Diabetes on the Commonwealth of Kentucky Kentucky Diabetes Prevention and Control Program, Department for Public Health MEMBERSHIP IN PROFESSIONAL SOCIETIES American Statistical Association International Biometric Society (ENAR) Society of Clinical Trials HONORS AND AWARDS R.L. Anderson Award for Outstanding Teaching (2001) Alpha Chi National Honor Society Undergraduate Inductee Phi Delta Lambda Nazarene Honor Society Undergraduate Inductee Outstanding Freshman Award Undergraduate Award CONFERENCES ATTENDED Joint Statistical Meetings, Salt Lake City, UT, July ENAR, Altanta, GA, March American Public Health Association Annual Meeting, Boston, MA, November Joint Statistical Meetings, Seattle, WA, July Trilinear Methods in Chemistry and Psychology (by invitation), Chania, Crete, June International Society for Pharmacoeconomics and Outcomes Research, 11 th Annual Meeting, Philadelphia, PA, May CBI: Phase IV and Patient Registries Conferences, Philadelphia, PA, September Midwest Biopharmaceutical Statistics Workshop, Ball State University, May Trilinear Methods in Chemistry and Psychology (by invitation), University of Kentucky, June Midwest Biopharmaceutical Statistics Workshop, Ball State University, May Statistical Methodology in Alzheimer s Disease Research II, University of Kentucky, May Nonlinear Models Conference, University of Kentucky, December STATISTICAL SOFTWARE KNOWLEDGE SAS, R (S-Plus Clone), SUDAAN, SPSS

393 Curriculum Vitae Chong Wang Chong Wang Chong Wang 2601 Hasbrouck Apartments Ithaca, NY Phone: (917) Fax : (607) [email protected] EDUCATION Ph.D. Statistics, Cornell University, 08/2006 Dissertation Committee: Bruce W. Turnbull (Advisor), J. T. Gene Hwang, Yrjö T. Gröhn, Martin T. Wells M.S. Statistics, Cornell University, 12/2004 B.S. Statistics and Probability, Peking University, Beijing, P.R. China, 07/2001 EMPLOYMENT 08/2006 present Visiting Assistant Professor, Department of Mathematics, Cornell University 08/2006 present Postdoctoral Associate, Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University 08/ /2006 Teaching Assistant, School of Operations Research and Industrial Engineering, Cornell University 08/ /2003 Teaching Assistant, Department of Mathematics, Cornell University 05/ /2001 Intern Statistician, No. 1 Motor Factory of China RESEARCH INTERESTS Longitudinal Data Analysis, Latent Class Modeling Diagnostic Test Evaluation, Design for Clinical Trials, Sequential Analysis Bayesian Statistical Modeling, Markov Chain Monte Carlo (MCMC) Methods Statistical Genomics, Bioinformatics, Statistical Inference for High-dimensional Data HONORS and AWARDS Student Paper Award, the Statistics in Epidemiology Section, American Statistical Association, 2006 Paper Award, Johne s Disease Integrated Program (JDIP) 2nd Annual Conference, 2006 Best Student Paper Award, International Chinese Statistical Association, 2005 Graduate School Travel Award and Fellowship, Cornell University 2005, 2006 Excellent Academic Award, Peking University, 2000 Eaglet Award, Peking University, 1998, 1999 Freshman Scholarship, Peking University, 1997 Silver Medal in CMO (Chinese Mathematics Olympic), st place in the Mathematics Olympic Contest of Jilin Province, China, 1996 PROFESSIONAL ACTIVITIES Referee for the journal Bioinformatics Member of American Statistical Association (ASA), Institute of Mathematical Statistics (IMS), International Biometric Society (ENAR), and International Chinese Statistical Association (ICSA) Page 1 of 3

394 Curriculum Vitae Chong Wang RESEARCH PAPERS Wang, C., Turnbull, B. W., Gröhn, Y. T., and Nielsen, S. S. (2006). Nonparametric estimation of ROC curves based on Bayesian models when the true disease state is unknown. Journal of Agricultural, Biological, and Environmental Statistics. To appear. Wang, C., Turnbull, B. W. and Gröhn, Y. T. (2006). Adjusting ROC curve estimates for covariates without gold standard tests, 2006 Proceedings of the American Statistical Association, Statistics in Epidemiology Section, Seattle, WA: American Statistical Association. To appear. Wang, C., Turnbull, B. W., Gröhn, Y. T., and Nielsen, S. S. (2006). Estimating ROC curves with covariates when there is no perfect reference test for diagnosis of Johne s disease. Journal of Dairy Science, 89, Liu, P., Wang, C. and Hwang, J. T. G. (2006). Spot effects on the distribution of p-values: a theory and application to cdna microarray data. Submitted. Palaniappan, R.U.M., Wang, C., and Chang,Y.F. (2006). Differentiation of Salmonella enterica serovars by oligonucleotide spotted array. To be submitted. Wang, C. and Hwang, J. T. G. (2006). Consistent empirical Bayes estimation of the proportion of true null hypotheses for microarray data. To be submitted. Wang, C., Turnbull, B. W., Gröhn, Y. T., and Nielsen, S. S. (2006). ROC analysis for longitudinal disease diagnostic data without a gold standard test. To be submitted. Wang, C. (2006). ROC analysis for cross-sectional and longitudinal disease diagnostic data without a gold standard test: application to Johne s disease in dairy cows, Ph.D. Thesis, Cornell University Wang, C., Turnbull, B. W. and Gröhn, Y. T. (2005). A flexible Bayesian approach to estimate ROC curves when there is no gold standard test, 2005 Proceedings of the American Statistical Association, Biometry Section, Minneapolis, MN: American Statistical Association, RESEARCH COLLABORATIONS Consultation for the Epidemiology and Biostatistics Core, Johne s Disease Integrated Program (JDIP), 2004-present o Assisted in designing protein array experiments in the NRI proposals by Dr. Bannantine s group in the National Animal Disease Center. o Performed sample size calculation in designing paratuberculosis experiments to estimate herd disease prevalence without perfect reference tests for Dr. Collins s Group in the University of Wisconsin, Madison o Analyzed longitudinal Johne s disease diagnostic data by using latent change-point modeling and Bayesian methodology for Dr. Nielsen s group in the Royal Veterinary and Agricultural University in Denmark. Collaboration with Dr. Chang s Lab, the College of Veterinary Medicine, Cornell University, o Developed regression models for the single-channel oligonucleotide array experiment for differentiation of Salmonella enterica serovars o Conducted analysis of single-channel microarray data including normalization, ANOVA modeling and hypothesis testing to find differentially expressed genes Collaboration with Dr. Brutnell s Lab, Boyce Tompson Institute, Cornell University, o Helped in developing statistical models for microarray experiments to study maize gene expression o Analyzed microarray data with mixed model using REML estimation and performed hypothesis testing to find differentially expressed genes Page 2 of 3

395 Curriculum Vitae Chong Wang TEACHING EXPERIENCE Lecturer for MATH171: Statistical Theory and Application Topics include combinatorial probability, mean and variance, independence, conditional probability, Bayes formula, population and sample distributions, law of large numbers, central limit theorem, statistical theories of point estimation, confidence intervals, testing hypotheses, linear regressions, and the least squares estimation. In the lab portion of the course, students learn and use computer-based methods for implementing the statistical methodology presented in the lectures. Recitation Instructor for OR&IE 270, OR&IE , Engineering Probability and Statistics, I & II A rigorous foundation in theory combined with the methods for modeling, analyzing, and controlling randomness in engineering problems. Topics include random variables, probability distributions, density functions, expectation and variance, multidimensional random variables, and important distributions including normal, Poisson, exponential, hypothesis testing, confidence intervals, and point estimation using maximum likelihood and the method of moments. Recitation Instructor for OR&IE 474, Statistical Data Mining A thorough grounding in probabilistic and computational methods for statistical data mining. Topics include supervised and unsupervised data mining, the framework of learning, performance measures and model selection, methodology, theoretical properties and computing algorithms used in parametric and nonparametric methods for regression and classification, Frequentist and Bayesian methods. Recitation Instructor for MATH 293, Calculus Introduction to ordinary and partial differential equations. Topics include: mathematical modeling; qualitative methods, numerical methods, Fourier series, linear partial differential equations, and linear systems of ordinary differential equations. Recitation Instructor for MATH 294, Linear algebra Topics include matrices, determinants, vector spaces, eigenvalues and eigenvectors, orthogonality and inner product spaces; applications include brief introductions to difference equations, Markov chains, and systems of linear ordinary differential equations. Teaching Assistant for MATH 471, Basic Probability Introduction to probability theory. Teaching Assistant for MATH 472, Statistics Introduction to mathematical theory of statistics and techniques for data analysis. SPECIAL SKILLS Proficient programming with C, C++, Matlab, S-plus, R Experienced in Minitab, SAS Experienced in Microsoft Office (Word, Excel, PowerPoint), and Latex REFERENCES Bruce W. Turnbull, Professor, Department of Statistical Science, and School of Operations Research & Industrial Engineering, Cornell University. Phone: (607) , [email protected] J. T. Gene Hwang, Professor, Department of Statistical Sciences and Department of Mathematics, Cornell University. Phone: (607) , [email protected] Yrjö T. Gröhn, Professor of Epidemiology and Chair, Department of Population Medicine and Diagnostic Sciences, Cornell University. Phone: (607) , [email protected] Michael Nussbaum, Professor, Department of Mathematics, Cornell University. Phone: (607) , [email protected] Page 3 of 3

396 David W. Fardo Contact Information Education Harvard School of Public Health Phone: (617) Department of Biostatistics Fax: (617) Huntington Avenue s: dfardo AT fas.harvard.edu Building 2, 4th floor dfardo AT hsph.harvard.edu Boston, MA Harvard University, Boston, Massachusetts USA Ph.D. Candidate, Biotatistics, August 2004 present Dissertation Topic: Novel Methodologies Applied to Family-Based Association Testing Advisor: Dr. Christoph Lange A.M., Biostatistics, June 2006 University of Kentucky, Lexington, Kentucky USA M.S., Statistics, August 2004 Miami University, Oxford, Ohio USA B.S., Mathematics and Statistics, May 2000 Minors in Economics and Spanish Summa Cum Laude Publications Fardo DW, Celedón JC, Raby BA, Weiss ST, Lange C On Dichotomizing Phenotypes in Family-Based Association Tests: Quantitative Phenotypes are not Always the Optimal Choice. Genetic Epidemiology 31: Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA Predictors of an Accurate Preoperative Sestamibi Scan for Single-Gland Parathyroid Adenomas. Archives of Surgery 142: Presentations Why family-based association makes sense in a genome-wide world: A comparison of study power Joint Statistical Meetings. August 2007, Salt Lake City, Utah Genome-Wide Family-Based Association (INVITED) Harvard Bioinformatics Journal Club. November 2006, Boston, Massachusetts About Dichotomized Continuous Traits in family-based association tests: Do you really need quantitative traits? Eastern North American Region - International Biometric Society Spring Meeting. March 2007, Atlanta Georgia 11th International Congress of Human Genetics. August 2006, Brisbane, Australia Incorporating linkage information in testing strategies for genome-wide association studies in family-based designs Mathematical and Statistical Aspects of Molecular Biology. April 2006, Dublin, Ireland Power Implications of the Dichotomized Continuous Trait FBAT American Society of Human Genetics Annual Meeting. October 2005, Salt Lake City, Utah International Genetic Epidemiology Society Annual Meeting. October 2005, Park City, Utah Research Students Conference. April 2005, Cambridge, England Channing Laboratory Family-Based Association Analysis Working Group Meeting (IN- VITED). March 2005, Boston, Massachusetts

397 Conferences Academic Experience Joint Statistical Meetings. August 2007, Salt Lake City, Utah Eastern North American Region - International Biometric Society Spring Meeting. March 2007, Atlanta, Georgia International Genetic Epidemiology Society Annual Meeting. Florida November 2006, Tampa, 11th International Congress of Human Genetics. August 2006, Brisbane, Australia Mathematical and Statistical Aspects of Molecular Biology. April 2006, Dublin, Ireland American Society of Human Genetics Annual Meeting. October 2005, Salt Lake City, Utah International Genetic Epidemiology Society Annual Meeting. October 2005, Park City, Utah Research Students Conference. April 2005, Cambridge, England Harvard School of Public Health Instructor (full responsibility) Summer 2006 Summer Preparatory Training Program (Probability & Operational Math) Teaching Assistant (lab/grading responsibilities) Fall 2007 BIO 232 (Methods I) Fall 2006 BIO 226 (Applied Longitudinal Analysis) Winter 2006 BIO 111 (Introduction to Programming in SAS) Fall 2005 BIO 222 (Basics of Statistical Inference) Spring 2005 BIO 211 (Regression and Analysis of Variance in Experimental Research) University of Kentucky Instructor (full responsibility) Spring 2004 STA 200 (Statistics: A Force in Human Judgement) Website: Fall 2003 STA 200 Summer 2003 STA 200 Teaching Assistant (lab/grading responsibilities) Summer 2004 STA 570 (Basic Statistical Analysis) Spring 2003 STA 200 Fall 2002 STA 570 Honors and Awards Harvard University Channing Laboratory Fellow Certificate of Distinction in Teaching Roadmap Fellow Ruth L. Kirschstein National Research Service Award Respiratory Genetics Training Grant University of Kentucky R. L. Anderson Teaching Award First Year Teaching Scholar (completed six-week program sponsored by the Teaching and Learning Center covering issues of first year students) Teaching Assistantship Daniel R. Reedy Quality Achievement Fellowship

398 Miami University William N. and Marjorie Liggett Presidential Scholarship McFarland Prize Mary Jeanette and Clifford Harvey Scholarship Comer-Reynolds Award in statistics Corwin Smith Prize J. Paul and John P. Albert Scholarship Koehler Prize Major General Benjamin T. Butler Scholarship Award U.S. Achievement Academy National College Scholarship Grant National College Mathematics Award Memberships Service American Society of Human Genetics American Statistical Association Institute of Mathematical Statistics International Genetic Epidemiology Society Golden Key National Honor Society Mortar Board Phi Beta Kappa Phi Kappa Phi Pi Mu Epsilon Harvard University Student Member, Disciplinary Board Mentor, Summer Program in Quantitative Sciences Biostatistics Representative, Harvard School of Public Health Student Government Student Committee Representative & Chair, Biostatistics Department University of Kentucky Graduate Student Representative, Statistics Department Miami University Student Advisory Board, Mathematics & Statistics Department

399 CURRICULUM VITAE MARY KATHERINE O NEILL RAYENS 543 College of Nursing Phone: (859) University of Kentucky FAX: (859) Lexington, KY [email protected] I. EDUCATION Dates Degree Institution BS in Biology University of Illinois at Urbana-Champaign MS in Statistics University of Kentucky PhD in Statistics University of Kentucky Dissertation: Properties of Tango s Index for Detecting Clustering in Time II. PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS Dates Title Institution Biostatistical Consultant Colleges of Medicine and Dentistry, University of Kentucky Research Associate College of Nursing, University of Kentucky Associate Director, Medical Center, Biostatistics Consulting Unit University of Kentucky Research Assistant Professor College of Nursing and Department of Pediatrics, University of Kentucky Research Assistant Professor College of Nursing, Department of Pediatrics, and School of Public Health, University of Kentucky Research Associate Professor College of Nursing, Department of Pediatrics, and School (eventually College) of Public Health, University of Kentucky Associate Professor Colleges of Nursing and Public Health, University of Kentucky 2008 present Professor Colleges of Nursing and Public Health, University of Kentucky

400 CURRICULUM VITAE Mary Kay Rayens, PhD II. AWARDS 1993 Student prize and travel fellowship from the International Biometric Society, Eastern North American Region, for the paper presentation Properties of Tango s index for detecting clustering in time (by O Neill, M.K.) Recipient of the Best of Image Award from Sigma Theta Tau International at the 33 rd Biennial Convention for the article Childhood physical and sexual abuse: Their relationship with depressive symptoms in adulthood (by Hall, L.A., Sachs, B., Rayens, M.K., and Lutenbacher, M. (1993). Image: The Journal of Nursing Scholarship, 25, ) First place award in the D. Jean Wood Nursing Scholarship Contest sponsored by the Southern Nursing Research Society for the paper presentation Mothers potential for child abuse: The roles of childhood abuse and social resources (by Hall, L.A., Sachs, B., and Rayens, M.K.) First place award in the D. Jean Wood Nursing Scholarship Contest sponsored by the Southern Nursing Research Society for the paper presentation Prevalence and correlates of depressive symptoms in college women (by Peden, A.R., Hall, L.A., Rayens, M.K., and Payne, L.) First place award in the D. Jean Wood Nursing Scholarship Contest sponsored by the Southern Nursing Research Society for the paper presentation Kindergarten children s knowledge of alcohol, tobacco, and other drugs (by Hahn, E.J., Hall, L.A., Rayens, M.K., Burt, A.V., Flathman, O., and Sheffel, K.L.) Editor s choice award given by American Journal of Orthodontics and Dentofacial Orthopedics for the paper The efficacy of a wax containing benzocaine in the relief of oral mucosal pain caused by orthodontic appliances (by Kluemper, G.T., Hiser, D.G., Jay, M.J., and Rayens, M.K.) University of Kentucky Wethington Award for research excellence and productivity Second place award for the poster Mental health of rural adolescents (by Peden, A.R., Reed, D.B. and Rayens, M.K.) presented at the 17th Annual Meeting of the American Psychiatric Nurses Association, Atlanta, GA, October Annual University of Kentucky Wethington Awards for research excellence and productivity Best of conference award for the poster, Factors related to quality of life for adolescents with asthma and their parents, (by Svavarsdottir, E.K., Burkhart, P.V., Orlygsdottir, B., Rayens, M.K., and Westneat, S.) Presented at the Royal College of Nursing Annual International Nursing Research Conference, Dundee, Scotland, May

401 CURRICULUM VITAE Mary Kay Rayens, PhD 2007 Recipient of the Best of Journal of Nursing Scholarship Award in the Clinical Scholarship category from Sigma Theta Tau International at the 39 th Biennial Convention for the article Testing an intervention to reduce negative thinking, depressive symptoms, and chronic stressors in low-income single mothers. (by Peden, A.R., Rayens, M.K., Hall, L.A., and Grant, E. (2005). Journal of Nursing Scholarship, 37(3), ) First place student poster award for the poster, GIS mapping: Tobacco smoke, radon, and lung cancer, (by Hayes, G., Rayens, M.K., and Robertson, H.) Presented at the Southern Nursing Research Society Annual Conference, Birmingham, AL, February III. TEACHING Classes 1996 NUR776 (Special Topics Seminar): Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 5 PhD students; 45 contact hours NUR776 (Special Topics Seminar): Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 5 PhD students; 45 contact hours NUR776 (Special Topics Seminar): Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 6 PhD students; 45 contact hours NUR794 Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 3 PhD students; 45 contact hours NUR794 Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 2 PhD students; 45 contact hours NUR794 Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 5 PhD students; 45 contact hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Fall; 11 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of the interaction via the posted course materials, , phone and office hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 8 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of the interaction via the posted course materials, , phone and office hours

402 CURRICULUM VITAE Mary Kay Rayens, PhD 2004 NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 5 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of the interaction via the posted course materials, , phone and office hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 10 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of the interaction via the posted course materials, , phone and office hours NUR794 Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 11 PhD students; 45 contact hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 12 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of interaction via the posted course materials, , phone and office hours NUR620 Independent Study in Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 1 PhD student; approximately 20 contact hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 6 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of interaction via the posted course materials, , phone and office hours NUR794 Analysis, Interpretation, and Presentation of Quantitative Data 3 credit hours; Spring; 10 PhD students; 45 contact hours NUR903 Applied Biostatistics for Outcomes Evaluation 4 credit hours; Spring; 9 DNP students; 20 in-class contact hours on 5 Saturdays with the remainder of interaction via the posted course materials, , phone and office hours. Short Courses and Guest Lectures Presented a six-week short course entitled Biostatistical Methods to faculty and residents in Internal Medicine; Spring Presented a six-week short course entitled Biostatistical Methods to faculty and residents in Internal Medicine; Spring Presented an eight-week course entitled Biostatistical Methods for Clinical Research to faculty and residents in Neonatology; Summer Discussed power estimation in the context of hypothesis testing and experiment planning for NUR792 students; 11/18/

403 CURRICULUM VITAE Mary Kay Rayens, PhD Discussed the use of parametric and nonparametric statistics in medical research, presented examples and provided graphs for NUR839 students; 10/14/98. Presented a lecture on the use of biostatistics in clinical research at the Residency Research Retreat for the College of Pharmacy; 8/5/99. Presented a two-lecture short course on biostatistical methods for injury data to the faculty and staff of the Kentucky Injury Prevention Center; 9/15/99 and 12/15/99. Discussed power estimation in the context of hypothesis testing and experiment planning for NUR792 students; 12/1/99. Presented a lecture on the use of biostatistics, including analysis methods and sample size calculation, to the Nephrology, Bone and Mineral Metabolism, Division of Internal Medicine; 5/3/00. Presented a lecture on the use of biostatistics in clinical research at the Residency Research Retreat for the College of Pharmacy; 8/10/00. Discussed power estimation in the context of hypothesis testing and experiment planning for NUR792 students; 11/29/00. Presented a lecture on the appropriate methods for the assessment of change in quantitative data to NUR793 students; 4/16/01. Discussed the use of biostatistics in clinical research at the Residency Research Retreat for the College of Pharmacy; 8/9/01. Discussed power estimation in the context of hypothesis testing and experiment planning for NUR792 students; 9/26/01. Presented a lecture on logistic regression to NUR794 students; 4/6/05. Presented a lecture on power analysis to NUR792 students; 11/14/07. III. ADVISING ACTIVITY Advising Statement: Since 1992, I have advised more than 300 graduate students from the Colleges of Nursing, Medicine, Dentistry, Pharmacy, and Health Sciences on planning, conducting, and/or analyzing data from their research projects. Advising topics include experimental design, power analysis, data collection, data entry, data analysis, and how to summarize results. Since 1999, I have served and/or currently serve as a co-chair, committee member, or outside examiner on the following dissertation, thesis, or capstone committees or as advisor for the following undergraduate research interns: - 5 -

404 CURRICULUM VITAE Mary Kay Rayens, PhD Co-chair for: Lou Ann Hartley, PhD in Nursing, 2003 (Dissertation: Longitudinal analysis of access to health care, use of preventive health services, and practice of health-related behaviors of Appalachian and non-appalachian adults in Kentucky). Gwendolyn Hayes, PhD student in Nursing. PhD Committee member for: Terri Loan, PhD in Nursing, 2000 (Dissertation: Predictors of ICU outcome in adults with severe traumatic brain injury). Barbara Nunley, PhD in Nursing, 2002 (Dissertation: Stress, hardiness, and psychological distress of elderly spousal caregivers of persons with dementia). Stanley (Lee) Ridner, PhD in Nursing, 2004 (Dissertation: Predicting smoking status in a college-age population). Sukjai Charoensuk, PhD in Nursing, 2005 (Dissertation: Factors influencing depression in Thai adolescents). Chizimuzo Okoli, PhD in Nursing, 2005 (Dissertation: Psychobehavioral effects of secondhand tobacco smoke exposure). Esam Al Khasib, PhD in Nursing, 2006 (Dissertation: Patterns of colorectal cancer in Appalachian Kentucky). Nancy York, PhD in Nursing, 2006 (Dissertation: Community readiness and local smoke-free policy development). Jennifer Hatcher, PhD in Nursing, 2006 (Dissertation: The mental health of African American single mothers). Kristin Ashford, PhD in Nursing, 2007 (Dissertation: Secondhand smoke exposure during and after pregnancy). Karen Heaton, PhD in Nursing, 2007 (Dissertation: Feedback Actigraphy and Sleep in Long-Haul Truckers). Robert (Tony) English, PhD in Physical Therapy, 2008 (Dissertation: Clinical functional testing in people years old: Expected performance values and correlations to muscle fitness and activity level)

405 CURRICULUM VITAE Mary Kay Rayens, PhD Kanok-on (Ann) Chaowiang, PhD in Nursing, 2008 (Dissertation: The Path Analytic Model of Depressive Symptoms among Thai Adolescents). Suzette Sewell Scheuermann, PhD in Nursing, 2008 (Dissertation: Sleep Disturbances and Sleep Quality in Women with Fibromyalgia). Gwen Hooper, PhD candidate in Nursing. Jessica Wilson, PhD candidate in Nursing. Theresa Broderick, PhD student in Nursing. Marilyn McNeill, PhD student in Nursing. Sue Hedgecock, PhD student in Nursing. Karma Cassidy, PhD student in Nursing. Liz Sturgeon, PhD student in Nursing. Julia Hall, PhD student in Nursing. Master s or Capstone Committee member for: Doug Hiser, MS in Orthodontics, Faraj Behbehani, MS in Orthodontics, Jeffrey Hendrix, MS in Orthodontics, Flora Chen, MS in Orthodontics, Brian Hardy, MS in Orthodontics, Michael Cherubini, MS in Orthodontics, Ross Russell, MS in Orthodontics, Mei Zhang, MPH, Fawwaz Abdel Al Aloul, MPH, Outside examiner for: Attila Cseh, PhD in Economics, 2006 (Dissertation: The labor market and mental health)

406 CURRICULUM VITAE Mary Kay Rayens, PhD Debra Huss, PhD in Psychology, 2007 (Dissertation: Comorbidity of pediatric migraine and sleep disturbances: The role of a dysfunctional autonomic nervous system). Undergraduate research intern advisor for: David Nicholson, BSN student (Fall 2007) IV. RESEARCH AND CREATIVE PRODUCTIVITY Funded and Pending External Grants: 1998 present Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Prevention of Depression in College Women: A Pilot Study (Ann Peden, PI) Co-investigator NINR, NIH Grant #R15 NR04203, 9/15/96 6/30/99, $102,900 School/Home-based Drug Prevention with Families at Risk (Ellen Hahn, PI) Co-investigator NINR, NIH Grant #R15 NR A1, 8/1/97 7/31/98, $102,130 Tobacco Policy Study (Ellen Hahn, PI) Co-investigator Robert Wood Johnson Smokeless States Program and the Coalition for Health and Agricultural Development , $121,978 Impact of Occupational Therapy on the Health Status of Elderly Veterans (Don Holleman, PI) Biostatistician Veterans Affairs Health Services Research and Development Service Grant #W , 10/1/98 9/30/01, $335,400 Biobehavioral Outcomes in Nutritional Supplementation (Mary DeLetter, PI) Co-investigator NINR, NIH Grant #R55 NR , 9/30/96 9/29/99, $100,000 Pilot Assessment of Home Health Services (Mary DeLetter, PI) Consultant Department of Veterans Affairs MidSouth Network 12/97 12/98, $20,400 Community Partnerships in Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Lexington Fayette-County Health Department) 9/1/98 8/31/99, $24,

407 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: Community Partnerships in Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Lexington Fayette-County Health Department) 9/1/99 8/31/00, $70,051 Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Community Partnerships in Tobacco Prevention and Cessation (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 9/1/00 6/30/01, $245,070 Kentucky Behavioral Health Reform Monitoring Project (Pat Howard, PI) Co-investigator US Department of Health and Human Services, Substance Abuse and Mental Health Services, Center for Mental Health Services 8/99 12/00, $197,314 Quality Improvement Hospital Outcomes Study at Central State Hospital, Louisville, Kentucky (Phase 1 and Phase 2), and at Western State Hospital, Hopkinsville, Kentucky (Phase 3); (Pat Howard, PI) Co-investigator Cabinet for Human Resources, Commonwealth of Kentucky, Department for Mental Health and Mental Retardation Services 2/98 1/01, $131,000 Community Partnerships in Tobacco Prevention and Cessation (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/01 6/30/02, $236,647 Prevention of Depression in Low-income Single Mothers (Ann Peden, PI) Co-investigator NINR, NIH 4/00 3/03, $684,325 Sustained Work Indicators of Older Farmers (Deborah Reed, PI) Co-investigator NIOSH/CDC 9/01 9/07, $1,188,250 Evaluation of Farm Safety 4 Just Kids Day Camps (Deborah Reed, PI) Co-investigator NIOSH/CDC 9/01 9/05, $590,

408 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: Testing the Effect of a Multi-component Statewide Tobacco Contest (Ellen Hahn, PI) Co-investigator American Legacy Foundation 9/01 8/02, $100,000 Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Multi-center Study: A Cross-sectional and Longitudinal Assessment of Outcome Instruments in Patients with Ambulatory Cerebral Palsy (Chester Tylkowski, PI) Biostatistician Shriners Hospitals for Children, Corporate Research , $784,323 Promoting Children s Adherence to Asthma Self-Management (Pat Burkhart, PI) Co-investigator NINR, NIH 8/02 7/06, $146,250 Testing the Effect of a Multi-component Statewide Smoking Cessation Contest (Continuation Funding Request; Ellen Hahn, PI) Co-investigator American Legacy Foundation 8/02 7/03, $29,275 (with an additional $29,275 funded by the UK Markey Cancer Center) Community Partnerships in Tobacco Prevention and Cessation (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/02 6/30/03, $161,425 Development of an Academic Nurse-Managed Center Survey and Database (Julie Sebastian and Marcia Stanhope, Co-PIs) Co-investigator Michigan Academic Nursing Consortium 1/1/03-12/15/03, $100,000. Biobehavioral Intervention in Heart Failure (Debra Moser, PI) Co-investigator NINR, NIH 6/04 2/09, $1,584,335 Physiologic and Behavioral Mechanisms Linking Depression with Increased Morbidity and Mortality in Patients with Heart Failure (Debra Moser, PI) Co-investigator American Association Critical Care Nurses 6/03 4/07, $98,

409 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: Community Partnerships for Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/03 6/30/04, $180,000 Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Breaking the Cycle: Smoking Intervention with Youth in Families Dealing with Lung Cancer (Catherine Martin, PI) Co-investigator Kentucky Lung Cancer Research Program 2/04 6/06, $290,628 Community Partnerships for Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/04 6/30/05, $140,000 Reducing SHTS: Cardiac and Asthma Outcomes (Ellen Hahn, PI) Co-investigator Flight Attendant Medical Research Institute Clinical Innovator Award 7/04 6/07, $325,062 Smoke-free Laws and Employee Turnover (Ellen Hahn, PI) Co-investigator Robert Wood Johnson Substance Abuse Policy Research Program 8/04 7/06, $241,790 Linkages between Anxiety and Outcomes in Heart Failure (Marla De Jong, PI) Advisor TriService Nursing Research Program 4/05 3/06, $40,078 Community Partnerships for Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/05 6/30/06, $150,000 BMI, Nutrition, Inflammation and Heart Failure Outcomes (Terry Lennie, PI) Co-investigator NIH, NINR 11/05 5/08, $1,521,436 Community Partnerships for Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/06 6/30/07, $110,

410 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: Impact of Family Distress and Burden in Patient Outcomes in Heart Failure (Misook Chung, PI) Co-sponsor NIH, NINR 7/1/06 6/30/09, $280,961 Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: An Intervention for Promoting Smoke-free Policy in Rural Kentucky (Ellen Hahn, PI) Co-investigator NCI, NHLBI 4/1/07 3/31/12, $3,173,787 Community Partnerships for Tobacco Prevention and Reduction (Ellen Hahn, PI) Co-investigator CDC (via a contract with the Kentucky Department of Public Health) 7/1/07 6/30/08, $140,000 HIV Testing Factors Among Rural/Small City Black Men (E.J. Brown, PI) Co-investigator CDC 9/07 8/11, $1,020,942 Center for Biobehavioral Research in Self-Management of Cardiopulmonary Disease (Debra Moser, PI) Co-director of the Research Program Development, Data Analysis and Dissemination Core NIH, NINR 9/07 6/12, $1,285,375 Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors (Celeste Shawler, PI) Co-sponsor (statistician) NIH; Funded Promoting Mammography in African American Women Visiting the Emergency Department (Jennifer Hatcher, PI) Co-sponsor NIH; Funded Biobehavioral Health Outcomes in Work-Life (Lynne Hall, PI) Core Faculty NIH, NINR; Pending Screening for Fetal Alcohol Spectrum Disorder with Cognitive and Behavioral Tools (Alison Connell, PI) Co-sponsor NIH; Pending

411 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: University of Kentucky Center for Clinical and Translational Science (William Balke, PI) Core Faculty (Member of the Executive Committee of Biostatistics, Design, and Research Ethics) NIH; Pending Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Secondhand Smoke and Lung Cancer Risk in Schools (Ellen Hahn, PI) Co-investigator FAMRI; Pending Effect of a Theory-Based, Medication-taking Behavior Feedback Intervention on Medication Adherence and Outcomes in Patients with Heart Failure (Jia-Rong Wu, PI) Advisor AACN; Pending Effects of a cognitive-educational therapy on outcome in patent-spouse dyads in heart failure (Misook Chung, PI) Advisor AACN; Pending Heart disease, Obesity, Injury and Nutritional Health Risks in Long-haul Truckers (Debra Anderson, PI) Co-investigator NIOSH; Pending How Wellness Programs in Correctional Substance Abuse Programs Improve Outcomes (Philip Curd, PI) Co-investigator NIH; Pending An Integrative Tobacco Treatment for Pregnant and Postpartum Women (Ann Peden, PI) Co-investigator NIDA; Pending Kentucky Oral Health Network (KOHN) (Center grant; Jeffrey Ebersole, PI) Co-investigator of the Statistics & Data Coordinating Center Core NIH; Pending Quality of Life, Morbidity and Mortality in Patients with Heart Failure (Debra Moser, PI) Co-investigator NIH; Pending

412 CURRICULUM VITAE Mary Kay Rayens, PhD Title: Role: Agency: Smoke-free Laws and Heart Attack Rates in a Southern State (Ellen Hahn, PI) Co-Principal Investigator Robert Wood Johnson Foundation; Pending Funded Internal Grants: 1998 present Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Title: Role: Agency: Factors Correlated with Admission to Extended Care for Older Veterans with a Diagnosis of Dementia (Philip DeSimone, PI) Consultant College of Medicine Associate Dean for Research 9/98 9/99, $3,339 Training and Implementation Fidelity of the Life Skills Training Program in Kentucky (Ellen Hahn, PI) Co-investigator UKMC Research Fund 7/99 6/00, $15,000 Improving Mental Health Outcomes Through a Primary Care Intervention (Ann Peden, PI) Co-investigator UKMC Research Fund 8/99 7/00, $15,000 Testing the Efficacy of a Smoking Cessation Program for College Students (Ruth Staten, PI) Co-investigator UKMC Research Fund 7/99 6/00, $15,000 Testing the Effect of a Multi-component Statewide Smoking Cessation Contest (Continuation Funding Request; Ellen Hahn, PI) Co-investigator UK Markey Cancer Center 8/02 7/03, $29,275 (with an additional $29,275 funded by the American Legacy Foundation) Mental Health and Smoking During and After Pregnancy (Ann Peden, PI) Co-investigator UK Research Support Grant Program 2/04 1/05, $18,100 Factors Related to Quality of Life for Adolescents with Asthma and Their Parents (Pat Burkhart, PI) Co-investigator UK Faculty Research Support Program 11/05-10/06, $15,

413 CURRICULUM VITAE Mary Kay Rayens, PhD Refereed Publications Rayens, M.K., and Kryscio, R.J. (1993). Properties of Tango s Index for detecting clustering in time. Statistics in Medicine, 12, Hall, L.A., Sachs, B., Rayens, M.K., and Lutenbacher, M. (1993). Childhood physical and sexual abuse: Their relationship with depressive symptoms in adulthood. Image: The Journal of Nursing Scholarship, 25, Pavlik, E.J., Van Nagell, J.R., DePriest, P.D., Wheeler, L., Tatman, J.M., Boone, M., Sollars, S., Rayens, M.K., and Kryscio, R.J. (1995). Participation in transvaginal ovarian cancer screening: Compliance, correlation factors, and costs. Gynecologic Oncology, 57, Hall, L.A., Kotch, J.B., Browne, D., and Rayens, M.K. (1996). Self-esteem as a mediator of the effects of stressors and social resources on depressive symptoms in postpartum mothers. Nursing Research, 45, Bruce, R.G., Rankin, W.R., Cibull, M.L., Rayens, M.K., Banks, E.R., and Wood, D.P. (1996). Single focus of adenocarcinoma in the prostate biopsy specimen is not predictive of the pathologic state of disease. Urology, 48, Fleming, D.R., Henslee-Downey, P.J., Romond, E.H., Harder, E.J., Marciniak, E., Munn, R.K., Messino, M.J., Macdonald, J.S., Bishop, M., Rayens, M.K., Thompson, J.S., and Foon, K.A. (1996). Allogeneic bone marrow transplantation with T cell-depleted partially matched related donors for advanced acute lymphoblastic leukemia in children and adults: A comparative matched cohort study. Bone Marrow Transplantation, 17, Falace, D.A., Reid, K., and Rayens, M.K. (1996). The influence of deep (odontogenic) pain intensity, quality, and duration on the incidence and characteristics of referred orofacial pain. Journal of Orofacial Pain, 10, Reid, K.I., Carlson, C., Rayens, M.K., and Gracely, R.H. (1996). The influence of cutaneous tissue afferents on masticatory pain-pressure thresholds. Journal of Orofacial Pain, 10, Fleming, D.R., Rayens, M.K., and Garrison, J. (1997). Impact of obesity on allogeneic stem cell transplant patients: A matched case-controlled study. American Journal of Medicine, 103, Munn, R.K., Henslee-Downey, P.J., Romond, E.H., Marciniak, E.J., Fleming, D.R., Messino, M.J., Macdonald, J.S., Rayens, M.K., Harder, E.J., Phillips, G.L., and Thompson, J.S. (1997). Treatment of leukemia with partially matched related bone marrow transplantation. Bone Marrow Transplantation, 19, Musgrave, Y.M., Davey, D.D., Weeks, J.A., Banks, E.R., Rayens, M.K., and Ain, K.B. Assessment of fine-needle aspiration sampling technique in thyroid nodules. (1998). Diagnostic Cytopathology, 18,

414 CURRICULUM VITAE Mary Kay Rayens, PhD Hall, L.A., Sachs, B. and Rayens, M.K. (1998). Mothers potential for child abuse: The roles of childhood abuse and social resources. Nursing Research, 47, Miller, C.S., Rolph, C., Lin, B., Rayens, M.K., and Rubeck, R.F. (1998). Evaluation of a computerassisted test engine in oral and maxillofacial radiography. Journal of Dental Education, 62, Carpenter, J.S., Andrykowski, M.A., Wilson, J., Hall, L.A., Rayens, M.K., Sachs, B., and Cunningham, L.L.C. (1998). Psychometrics for two short forms of the Center for Epidemiologic Studies--Depression Scale. Issues in Mental Health Nursing, 19, Chabra, S., Cottrill, C., Rayens, M.K., Cross, R., Lipke, D., and Bruce, M. (1998). Lymphocyte subsets in cord blood of preterm infants: Effect of antenatal steroids. Biology of the Neonate, 74, Stiles, N.S., Boosalis, M., Thompson, K., Stinnett, D., and Rayens, M.K. (1998). Nutrition telemedicine consultation with rural elders. Journal of Nutrition for the Elderly, 18(1), Hahn, E.J., Toumey, C., Rayens, M.K., and McCoy, C. (1999). Kentucky legislators views on tobacco policy. American Journal of Preventive Medicine, 16(2), Miller, C.S., Egan, R.M., Falace, D.A., Rayens, M.K., and Moore, C.R. (1999). Prevalence of infective endocarditis in patients with systemic lupus erythematosus. Journal of the American Dental Association, 130, Hahn, E.J. and Rayens, M.K. (1999). Consensus for tobacco policy among former state legislators using the policy Delphi method. Tobacco Control, 8(2), Sachs, B., Hall, L.A., Lutenbacher, M., and Rayens, M.K. (1999). Potential for abusive parenting by rural mothers of low birth weight children. Image: The Journal of Nursing Scholarship, 31(1), Brosky, J.A., Nitz, A.J., Malone, T.R., Caborn, D.N.M., and Rayens, M.K. (1999). Intrarater reliability of selected clinical outcome measures following anterior cruciate ligament reconstruction. Journal of Orthopaedic & Sports Physical Therapy, 29(1), Sachs, B., Hall, L.A., Lutenbacher, M., and Rayens, M.K. (1999). The physical health of rural mothers and their low birth weight children. Journal of Community Health Nursing, 16(4), Hahn, E.J. and Rayens, M.K. (2000). Public opinion and legislators views on tobacco policy. Journal of the Kentucky Medical Association, 98(2), Hahn, E.J., Hall, L.A., Rayens, M.K., Burt, A.V. Corley, D., and Sheffel, K.L. (2000). Kindergarten children's knowledge and perceptions of alcohol, tobacco, and other drugs. Journal of School Health, 70(2),

415 CURRICULUM VITAE Mary Kay Rayens, PhD Peden, A.R., Hall, L.A., Rayens, M.K., and Payne, L.L. (2000). Negative thinking mediates the effect of self-esteem on depressive symptoms in college women. Nursing Research, 49(4), Peden, A.R., Hall, L.A., Rayens, M.K., and Beebe, L.L. (2000). Reducing negative thinking and depressive symptoms in college women. Journal of Nursing Scholarship, 32(2), Martin, C.A., Rayens, M.K., Kelly, T.H., Hartung, C., Leukefeld, C. and Haigler, E. (2000). Card perseveration task performance and post-task feeling states: Relationship to drug use in adolescents. American Journal of Drug and Alcohol Abuse, 26(2), Yokel, R.A., Fredenburg, A.M., Durbin, P.W., Xu, J., Rayens, M.K., and Raymond, K.N. (2000). The hexadentate hydroxypyridinonate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue. Journal of Pharmaceutical Sciences, 89(4), Hoffmann, M., Berger, J., Nath, A., and Rayens, M. (2000). Cerebrovascular disease in young, HIV-infected, black Africans in the KwaZulu Natal Province of South Africa. Journal of Neurovirology, 6(3), Rayens, M.K. and Hahn, E.J. (2000). Building consensus using the policy Delphi method. Policy, Politics, & Nursing Practice, 1(4), Howard, P.B., Clark, J.J., Rayens, M.K., Hines-Martin, V., Littrell, R., and Weaver, P. (2001). Consumer satisfaction with services in a regional psychiatric hospital: A collaborative research project in Kentucky. Archives of Psychiatric Nursing, 15(1), Sheahan, S.L., Simpson, C., & Rayens, M.K. (2001). Nurse practitioner peer review: Process and evaluation. Journal of the American Academy of Nurse Practitioners, 13(3), Peden, A.R., Rayens, M.K., Hall, L.A., & Beebe, L. (2001). Preventing depression in high-risk college women: A report of an 18-month follow-up. Journal of American College Health, 49(6), Hahn, E.J., Rayens, M.K., and Rasnake, R.T. (2001). Are Kentucky Schools Using Research-based Curricula? Foresight, 8(2), 6-9. Reed, D.B., Kidd, P.S., Westneat, S.C., and Rayens, M.K. (2001). Agricultural disability awareness and risk education (AgDARE) for high school students. Injury Prevention, 7(s), i59-i63. Hahn, E.J. and Rayens, M.K. (2002). Legislators views on tobacco policy: Are there regional differences in Kentucky? Southern Medical Journal, 95(3), Hahn, E.J., Rayens, M.K., Chaloupka, F.J., Okoli, C., and Yang, J. (2002). Projected smokingrelated deaths among U.S. youth: A 2000 update. ImpacTeen Research Paper Series, University of Illinois at Chicago Health Research and Policy Center,

416 CURRICULUM VITAE Mary Kay Rayens, PhD Barton, S.J., Howard, P., and Rayens, M.K. (2002). The effects of infant feeding decisions on infant growth. Journal for Specialists in Pediatric Nursing, 7(2), Hahn, E.J., Noland, M.P., Rayens, M.K., and Christie, D.M. (2002). Efficacy of training and implementation fidelity of the Life Skills training program. Journal of School Health, 72(7), Kluemper, G.T., Hiser, D.G., Jay, M.J., and Rayens, M.K. (2002). The efficacy of a wax containing benzocaine in the relief of oral mucosal pain caused by orthodontic appliances. American Journal of Orthodontics and Dentofacial Orthopedics, 122(4), Martin, C.M., Kelly, T.H., Rayens, M.K., Brogli, B.R., Brenzel, A., Smith, W.J., and Omar, H.A. (2002). Sensation seeking, puberty and nicotine, alcohol, and marijuana use in adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 41(12), Sheahan, S.L., Free, T.A., and Rayens, M.K. (2003). Smoking behavior and desire to quit among low income female caregivers. Applied Nursing Research, 16(3), Miller, C.S., Henry, R.G., and Rayens, M.K. (2003). Disparities in risk of and survival from oropharyngeal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 95(5), Kidd, P., Reed, D.B., Weaver, L., Westneat, S., Rayens, M.K. and Wilson, K. (2003). The transtheoretical model of change: Implications for adolescent injury. Journal of Safety Research, 34(3), Rayens, M.K. and Svavarsdottir, E.K. (2003). A new methodological approach in nursing research: An actor, partner and interaction effect model for family outcomes. Research in Nursing & Health, 26(5), Barton, S., Gaffney, R., Chase, T., Rayens, M., & Piyabanditkul, L. (2003). Pediatric temperature measurement and child/parent/nurse preference using three temperature measurement instruments. Journal of Pediatric Nursing, 18(5), Yan, F.X., Langub, M.C., Ihnen, M.A., Hornung, C., Juronen, E., Rayens, M.K., Cai, W.M., Wedlund, P.J., and Fanti, P. (2003). CYP2D6, GSTM1 and GSTT1 enzymes: Expression in parathyroid gland and association with parathyroid hormone level during early renal replacement therapy. British Journal of Clinical Pharmacology, 56(1), Svavarsdottir, E.K. and Rayens, M.K. (2003). American and Icelandic parents perceptions of the health status of their young children with chronic asthma. Journal of Nursing Scholarship, 35(4), Howard, P.B., El-Mallakh, P., Rayens, M.K., and Clark, J.J. (2003). Consumer perspectives on quality of inpatient mental health services. Archives of Psychiatric Nursing, 17(5),

417 CURRICULUM VITAE Mary Kay Rayens, PhD Anderson, D.G. and Rayens, M.K. (2004). Factors influencing homelessness in women. Public Health Nursing 21(1), Hahn, E.J., Rayens, M.K., Okoli, C.T.C, Love, K., and Kim, S. (2004). Tobacco use prevention and cessation policies in manufacturing facilities in the tobacco-growing state of Kentucky. American Journal of Health Promotion, 18(3), Howard, P.B., El-Mallak, P., Rayens, M.K., and Clark, J.J. (2004). Patient satisfaction and treatment outcomes as quality indicators for mental health services. International Psychiatry, 5, 5-6. Hall, L.A., Peden, A.R., Rayens, M.K., and Beebe, L. (2004). Parental bonding: A key factor for mental health of college women. Issues in Mental Health Nursing, 25(3), Martin, C.A., Kelly, T.H., Rayens, M.K., Brogli, B., Himelreich, K., Brenzel, A., Bingcang, C.M., and Omar, H. (2004). Sensation seeking and symptoms of disruptive disorder: Association with nicotine, alcohol, and marijuana use in early and mid-adolescents. Psychological Reports, 94(3), Oeffinger, D.J., Tylkowski, C.M., Rayens, M.K., Davis, R.F., Gorton, G.E., D Astous, J., Nicholson, D., Damiano, D.L., Abel, M.F., Bagley, M.F., and Luan, J. (2004). Gross Motor Function Classification System and outcome tools for assessing ambulatory cerebral palsy: A multicenter study. Developmental Medicine and Child Neurology, 46(5), Peden, A.R., Rayens, M.K., Hall, L.A., and Grant, E. (2004). Negative thinking and the mental health of low-income single mothers. Journal of Nursing Scholarship, 36(4), Hahn, E.J., Rayens, M.K., Chirila, C., Riker, C.A., Paul, T.P., and Warnick, T.A. (2004). Effectiveness of a Quit and Win contest with a low income population. Preventive Medicine, 39(3), Barton, S.J., Chase, T., Latham, B., and Rayens, M.K. (2004). Comparing two methods to obtain blood specimens from pediatric central venous catheters. Journal of the Association of Pediatric Oncology Nurses, 21(6), Burkhart, P.V., Rayens, M.K., Bowman, R.M. (2005). Evaluation of children s metered-dose inhaler technique. Nursing Clinics of North America, 40(1), Svavarsdottir, E.K. and Rayens, M.K. (2005). Hardiness in families of young children with asthma. Journal of Advanced Nursing, 50(4), Peden, A.R., Rayens, M.K., and Hall, L.A. (2005). A community-based depression prevention intervention with low-income single mothers. Journal of the American Psychiatric Nurses Association, 11(1), Hahn, E.J., Rayens, M.K., Rasnake, R., York, N., Okoli, C.T.C., and Riker, C.A. (2005). School policies in a tobacco growing state. Journal of School Health, 75(6),

418 CURRICULUM VITAE Mary Kay Rayens, PhD Peden, A.R., Rayens, M.K., Hall, L.A., and Grant, E. (2005). Testing an intervention to reduce negative thinking, depressive symptoms, and chronic stressors in low-income single mothers. Journal of Nursing Scholarship, 37(3), Hahn, E.J., Rayens, M.K., Warnick, T.A., Chirila, C., Rasnake, R.T., Paul, T., and Christie, D. (2005). A controlled trial of a Quit and Win contest. American Journal of Health Promotion, 20(2), Peden, A.R., Reed, D.B., and Rayens, M.K. (2005). Depressive symptoms in adolescents living in rural America. Journal of Rural Health, 21(4), Miller, K., Staten, R.R., Rayens, M.K., and Noland, M.P. (2005). Levels and characteristics of physical activity among a college student cohort. American Journal of Health Education, 36(4), Wermeling, D.P., Miller, J.L., Archer, S.M., Rayens, M.K., and Rudy, A.C. (2005). Pharmacokinetics, bioequivalence, and spray weight reproducibility of intranasal butorphanol after administration with 2 different nasal spray pumps. Journal of Clinical Pharmacology, 45(8), Svavarsdottir, E.K., Rayens, M.K., and McCubbin, M. (2005). Predictors of adaptation in Icelandic and American families of young children with chronic asthma. Journal of Family and Community Health, 28(4), Burkhart, P.V., and Rayens, M.K. (2005). Self-concept and health locus of control: Factors related to children s adherence to recommended asthma treatment regimen. Pediatric Nursing, 31(5), Staten, R.R., Miller, K.H., Noland, M.P., and Rayens, M.K. (2005). College students physical activity: Application of an ecological perspective. American Journal of Health Studies, 20(1), Behbehani, F., Hicks, E.P., Beeman, C., Kluemper, T., and Rayens, M.K. (2006). Racial variations in cephalometric analysis between Caucasians and Kuwaitis. The Angle Orthodontist, 76(3), Hahn, E.J., Rayens, M.K., Kirsh, K.L., and Passik, S.D. (2006). Pain and readiness to quit smoking cigarettes. Nicotine & Tobacco Research, 8(3), Hahn, E.J., Rayens, M.K., Hopenhayn, C., and Christian, W.J. (2006). Perceived risk and interest in screening for lung cancer among current and former smokers. Research in Nursing & Health, 29(4), Hahn, E.J., Rayens, M.K., York, N., Okoli, C.T.C., Zhang, M., Dignan, M., and Al-Delaimy, W.K. (2006). Effects of a smoke-free law on hair nicotine and respiratory symptoms in restaurant and bar workers. Journal of Occupational and Environmental Medicine, 48(9),

419 CURRICULUM VITAE Mary Kay Rayens, PhD Martin, C.A., Guenthner, G., Bingcang, C., Smith, W.J., Curry, T., Omar, H.A., Rayens, M.K., and Kelly, T.H. (2006). A pilot study: Attention deficit hyperactivity disorder, sensation seeking and pubertal changes. TheScientificWorldJOURNAL, 6, Sheahan, S.L., Rayens, M.K., An, K., Riegel, B., McKinley, S., Doering, L., Garvin, B.J., and Moser, D.K. (2006). Comparison of anxiety between smokers and nonsmokers with acute myocardial infarction. American Journal of Critical Care, 15(6), Martin, C.A., Guenthner, G., Bingcang, C., Rayens, M.K., and Kelly, T.H. (2007). Measurement of the subjective effects of methylphenidate in ADHD year olds. Journal of Child and Adolescent Psychopharmacology, 17(1), Martin, C.A., Lommel, K., Cox, J., Kelly, T., Rayens, M.K., Woodring, J.H., and Omar, H. (2007). Kiss and tell: What do we know about pre- and early adolescent females who report dating? A pilot study. Journal of Pediatric and Adolescent Gynecology, 20(1), Burkhart, P.V., Rayens, M.K., Revelette, R., and Ohlmann, A.B. (2007). Improved health outcomes with peak flow monitoring for children with asthma. Journal of Asthma, 44(2), Okoli, C.T.C., Hall, L.A., Rayens, M.K., and Hahn, E.J. (2007). Measuring tobacco smoke exposure among smoking and nonsmoking bar and restaurant workers. Biological Research for Nursing, 9(1), Howard, P.B., El-Mallakh, P., Rayens, M.K., and Clark, J.J. (2007). Comorbid medical illnesses and perceived general health among adult recipients of Medicaid mental health services. Issues in Mental Health Nursing, 28(3), Staten, R.R., Noland, M., Rayens, M.K., Hahn, E., Dignan, M., and Ridner, L. (2007). Social influences on cigarette initiation among college students. American Journal of Health Behavior, 31(4), Burkhart, P.V., Rayens, M.K., Oakley, M.G., Abshire, D.A., and Zhang, M. (2007). Testing an intervention to promote children s adherence to asthma self-management. Journal of Nursing Scholarship, 39(2), Okoli, C.T.C., Rayens, M.K., and Hahn, E.J. (2007). Behavioral effects of nicotine exposure from secondhand tobacco smoke among bar and restaurant workers. Addictive Behaviors, 32(9), Howard, P.B., Rayens, M.K., El-Mallakh, P., and Clark, J.J. (2007). Predictors of satisfaction among adult recipients of Medicaid mental health services. Archives of Psychiatric Nursing, 21(5), Hahn, E.J., Hall, L.A., Rayens, M.K., Myer, A.V., and Bonnel, G. (2007). School and home-based drug prevention: Environmental, parent, and child risk reduction. Drugs: Education, Prevention & Policy, 14(4),

420 CURRICULUM VITAE Mary Kay Rayens, PhD Pohl, J.M., Sebastian, J.G., Barkauskas, V.H., Breer, M.L., Williams, C.A., Stanhope, M., Nagelkirk, J., and Rayens, M.K. (2007). Characteristics of Schools of Nursing (SONs) operating nurse-managed centers. Nursing Outlook, 55(5), Rayens, M.K., Hahn, E.J., Langley, R.E., Hedgecock, S., Butler, K.M., and Greathouse-Maggio, L. (2007). Public opinion and smoke-free laws. Policy, Politics & Nursing Practice, 8(4), Okoli, C.T.C., Browning, S., Rayens, M.K., Hahn, E.J. (2008). Secondhand tobacco smoke exposure, nicotine dependence, and smoking cessation. Public Health Nursing, 25(1), Riegel, B., Moser, D.K., Rayens, M.K., Carlson, B., Pressler, S.B., Shively, M., Albert, N.M., Armola, R., Evangelista, L., and Sethares, K. (2008). Ethnic differences in quality of life in persons with heart failure. Journal of Cardiac Failure, 14(1), 1-7. Rayens, M.K., Hahn, E.J., Langley, R.E., and Zhang, M. (2008). Public support for smoke-free laws in rural communities. American Journal of Preventive Medicine, 34(6), Hall, L.A., Rayens, M.K., and Peden, A.R. (2008). Maternal factors associated with child behavior. Journal of Nursing Scholarship, 40(2), Peden, A.R., Rayens, M.K., Hall, L.A., Hahn, E.J., Riker, C., Ashford, K., and Zhang, M. (in press). A mental health intervention to help pregnant smokers quit. Manuscript to appear in Addictive Disorders and Their Treatment. Thompson, E., Hahn, E.J., Blomquist, G., Garen, J., and Mullineaux, D.J., Ogunro, N., Rayens, M.K. (in press). Smoke-free laws and employee turnover. Manuscript to appear in Contemporary Economic Policy. Rayens, M.K., Hahn, E.J., and Hedgecock, S. (in press). Readiness to quit smoking in rural communities. Manuscript to appear in Issues in Mental Health Nursing. York, N., Hahn, E.J., Rayens, M.K., and Talbert, J. (in press). Community readiness for local smoke-free policy change. Manuscript to appear in American Journal of Health Promotion. Butler, K.M., Rayens, M.K., Zhang, M., Maggio, L.G., Riker, C., and Hahn, E.J. (in press). Tobacco dependence treatment education with undergraduate nursing students. Manuscript to appear in Journal of Nursing Education. Hahn, E.J., Rayens, M.K., Butler, K.M., Zhang, M., Durbin, E., and Steinke, D. (in press). Smokefree laws and adult smoking prevalence. Manuscript to appear in Preventive Medicine. Skärsäter, I., Rayens, M.K., Peden, A.R., Hall, L.A., Zhang, M., Ågren, H., and Prochazka, H. (in press). Sense of coherence and recovery from major depression: A four-year follow-up. Manuscript to appear in Archives of Psychiatric Nursing

421 CURRICULUM VITAE Mary Kay Rayens, PhD Rayens, M.K., Burkhart, P.V., Zhang, M., Lee, S., Moser, D.K., Mannino, D., and Hahn, E.J. Reduction in asthma-related emergency department visits after implementation of a smoke-free law. Manuscript to appear in Journal of Allergy and Clinical Immunology. Manuscripts Under Review Rayens, M.K., Hall, L.A., Peden, A.R., Hahn, E.J., Reed. D., Miller, K.H., and Staten, R.R. Factor structure of the Center for Epidemiologic Studies Depression Scale: A study of women across the life span. Manuscript submitted to Depression and Anxiety. Reed, D.B., Claunch, D.T., and Rayens, M.K. FS4JK Farm Safety Day Camps Who learns the most? Manuscript submitted to Journal of Agricultural Safety and Health. Hatcher, J., Rayens, M.K., and Reed, D.B. Psychometric evaluation of the John Henry Selfefficacy Scale in a sample of older farmers. Manuscript submitted to Journal of Nursing Measurement. Ashford, K.B., Peden, A.R., Hahn, E.J., Rayens, M.K., and Hall, L.A. Postpartum smoking abstinence and smoke-free environments. Manuscript submitted to Birth. Hatcher, J., Peden, A.R., Hall, L.A., and Rayens, M.K. Predictors of depression in low-income African American single mothers. Manuscript submitted to Journal of Health Disparities Research and Practice. Reed, D.B., Rayens, M.K., and Winter, K., and Zhang, M. Health care delay of aging farmers. Manuscript submitted to American Journal of Industrial Medicine. Hahn, E.J., Rayens, M.K., Zhang, M., Lee, S., Burkhart, P.V. and Moser, D.K. Gender, smokefree laws and reduction in hospitalizations for acute myocardial infarction. Manuscript submitted to Archives of Internal Medicine. York, N.L., Hahn, E.J., Rayens, M.K., and Talbert, J. Local elected officials views on smoke-free policy in Kentucky. Manuscript submitted to Kentucky Journal of Communication. Butler, K.M., Rayens, M.K., Zhang, M., and Hahn, E.J. Telephone interviews as an adjunct to a quit smoking contest. Manuscript submitted to Kentucky Journal of Communication. Chung, M.L., Moser, D.K., Lennie, T.A., and Rayens, M.K. The effects of depressive symptoms and anxiety on quality of life: Testing dyadic dynamics using Actor-Partner Interdependence Model. Manuscript submitted to Journal of Psychosomatic Research. Howard, P.B., El-Mallakh, P., Miller, A.L., Rayens, M.K., Bond, G., Henderson, K., and Cooley, A.T., Prescriber fidelity to a medication management evidence-based practice in the treatment of schizophrenia. Manuscript submitted to Psychiatric Services

422 CURRICULUM VITAE Mary Kay Rayens, PhD Non-refereed Publications Hahn, E.J., Rayens, M.K., Toumey, C.P. and McCoy, C.A. (October 1998). Building consensus with decision-makers in Kentucky (pp ). In No more lies: Truth or consequences for tobacco, case studies. Fourth Annual National Conference on Tobacco and Health, St. Paul, MN. Howard, P.B., Clark, J.J., Rayens, M.K., Coyle, R., and Littrel, R. (September 1999). Satisfaction as an outcome indicator of quality in mental health services at Western State Hospital. This summary of study findings was submitted to the Director of Western State Hospital, Hopkinsville, KY. Howard, P.B., Clark, J.J., Rayens, M.K., and Coyle, R. (June 2000). Satisfaction as an outcome indicator of quality in mental health services at Central State Hospital. This summary of study findings was submitted to the Director of Central State Hospital, Louisville, KY. Howard, P.B., Rayens, M.K., Clark, J.J., and Coyle, R. (August 2000). Satisfaction with mental health services: Report on the Medicaid adult population. This summary of study findings was submitted to the Kentucky Department of Mental Health and Mental Retardation Services, Frankfort, KY. Hahn, E.J., Plymale, M.A., and Rayens, M.K. in collaboration with Lawther, G. and Dunne, L. (March 2001). Kentucky Youth Tobacco Survey This report summarizes the results of the 2000 Kentucky Youth Tobacco Survey was submitted to the Kentucky Department for Public Health in Frankfort, KY, for statewide circulation. Hahn, E.J., Rayens, M.K., Greathouse, L., King, E., Okoli, C.T.C, Hartley, L.A., and Yoder, A. (September 2002). Kentucky Tobacco Use Prevention and Cessation Report Card. This report summarizes the indicators of prevention and cessation of tobacco use for each of the 10 CDC-funded health departments as well as for all non-funded health departments around the state; it was submitted to the Kentucky Department for Public Heath in Frankfort, KY, for statewide circulation. Hahn, E.J., Rayens, M.K., Riker, C., Greathouse, L., Rasnake, R., Okoli, C., Hedgecock, S., Paul, T, and Wood, T. (September, 2003). Kentucky Tobacco Use Prevention and Cessation Status Report, Presented to the Kentucky Department of Public Health in Frankfort, KY, for statewide circulation. Hahn, E.J., Rayens, M.K., Riker, C., Greathouse, L., Rasnake, R., Okoli, C., Cavendish, S., Wood, T., and Gresham, K. (September, 2004). Kentucky Tobacco Prevention and Cessation Status Report, Presented to the Kentucky Department of Public Health in Frankfort, KY, for statewide circulation. Hahn, E.J., Rayens, M.K., Greathouse Maggio, L., Riker, C., Robertson, H., Peiper, N., Pasley, G., Okoli, C., Hedgecock, S., Cavendish, S., Lee, S., and McGee, J.M. (May 2006). Secondhand Soke and Smoke-free Policy. Prepared in collaboration with the Kentucky Department of Public Health in Frankfort, KY, for statewide circulation

423 CURRICULUM VITAE Mary Kay Rayens, PhD Abstracts (excluding those published as part of conference proceedings) Saxe, S.R., Anderson, J.W., O Neill, M.K., Kryscio, R.J., and Bridges, R.B. (1989). Bleeding and gingival indices in diabetic vs. non-diabetic patients American Association of Dental Research Abstracts. Bridges, R.B., Saxe, S.R., Anderson, J.W., O Neill, M.K., and Kryscio, R.J. (1989). Diabetes and loss of connective tissue attachment American Association of Dental Research Abstracts. Adams, G.L., Saxe, S.R., Anderson, J.W., O Neill, M.K., Kryscio, R.J., and Bridges, R.B. (1989). Tooth loss in diabetic vs. non-diabetic populations American Association of Dental Research Abstracts. Burkhart, P.V., Rayens, M.K., and Revelette, R. (February 2006) Asthma Outcomes Improve with Peak Flow Monitoring. Journal of Allergy and Clinical Immunology: February, 2006 Supplement. Paper Presentations Invited Rayens, M.K. (April 2001). Research at the University of Kentucky Medical Center: How does a biostatistician contribute? Fifteenth Annual Eastern Kentucky University Symposium in the Mathematical, Statistical, and Computer Sciences, Richmond, KY. Rayens, M.K. (April 2003). Enhancing practice through clinical research findings. Kentucky Coalition of Nurse Practitioners and Nurse Midwives Annual Conference, Cincinnati, OH. International Hall, L.A., Sachs, B., O Neill, M.K., and Kryscio, R.J. (May 1991). Single-mother families: Predictors of health outcomes. Second International Family Nursing Conference, Portland, OR. Sachs, B., Hall, L.A., and O Neill, M.K. (November 1991). Maternal depressive symptoms and child abuse potential: Their relationship to child behavior. Sigma Theta Tau International Biennial Convention, Tampa, FL. Hall, L.A., Sachs, B., and O Neill, M.K. (May 1992). Mothers potential for child abuse: The role of childhood physical and sexual abuse. Sigma Theta Tau International Nursing Research Conference, Columbus, OH. O Neill, M.K. (March 1993). Properties of Tango s index for detecting clustering in time. International Biometric Society, Eastern North American Region, Philadelphia, PA

424 CURRICULUM VITAE Mary Kay Rayens, PhD Hall, L.A., Kotch, J.B., Browne, D.H., and Rayens, M.K. (June 1993). Psychosocial predictors of depressive symptoms in postpartum mothers of high risk infants. Sigma Theta Tau International Nursing Research Congress, Madrid, Spain. Hall, L.A., Browne, D.H., Kotch, J.B., and Rayens, M.K. (October 1993). Psychosocial factors associated with psychosomatic symptoms in postpartum mothers of high risk infants. North American Congress on Women s Health Issues, Toronto, Ontario, Canada. Hall, L.A., Rayens, M.K., Kotch, J.B., and Browne, D. (May 1994). Postpartum mental health: The test of a causal model. International Nursing Research Conference, Vancouver, British Columbia, Canada. Rayens, M.K. (August 1994). A modified version of Tango s index for detecting clustering among continuously-recorded events. Joint Statistical Meetings, including American Statistical Association, International Biometric Society, Institute for Mathematical Statistics and Statistical Society of Canada, Toronto, Canada. Hall, L.A., Sachs, B., and Rayens, M.K. (June 1997). Factors influencing the parenting attitudes and child abuse potential of rural mothers with low birth weight children. Sigma Theta Tau International Nursing Research Congress, Vancouver, British Columbia, Canada. Sachs, B., Hall, L.A., and Rayens, M.K. (June 1997). Working with communities to improve health care delivery to rural families with low birth weight children. Sigma Theta Tau International Nursing Research Congress, Vancouver, British Columbia, Canada. Rayens, M.K. and Hahn, E.J. (March 1999). Assessing Baseline Consensus and Convergence Toward Agreement. International Biometric Society, Eastern North American Region, Atlanta, GA. Martin, C.A., Kelly, T.H., Delzer, T., and Rayens, M.K. (June 1999). The interaction between sensation seeking and conduct disorder symptoms predicts drug use and amphetamine response. College on Problems of Drug Dependence 61 st Annual Scientific Meeting, Acapulco, Mexico. Hoffmann, M., Berger, J.R., Nath, A., and Rayens, M. (June 2000). Cerebrovascular disease in young, HIV-infected, black Africans in the KwaZulu Natal Province of South Africa. Royal College of Physicians Edinburgh Conference, Edinburgh, Scotland. Peden, A.R., Reed, D.B., and Rayens, M.K. (October 2003). Mental health of rural adolescents. The Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities: Fifth International Symposium Saskatoon, SK, Canada. Reed, D.R., Claunch, D., Rayens, M.K., and Slusher, D. (July 2004). Evaluation of communitybased farm safety education for children. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland

425 CURRICULUM VITAE Mary Kay Rayens, PhD Rayens, M.K., Hall, L.A., Peden, A.R., Hahn, E.J., and Reed, D. (July 2004). Factor structure of the Center for Epidemiologic Studies Depression Scale: A study of women across the life span. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Burkhart, P.V., Rayens, M.K., and Barry, J. (July 2004). Self-concept and health locus of control: Factors related to children s adherence to recommended asthma treatment. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Peden, A.R., Hall, L.A., and Rayens, M.K. (July 2004). Prevention of depression in low-income single mothers. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Hahn, E.J., Rayens, M.K., and Okoli, C. (July 2004). Secondhand tobacco smoke exposure among restaurant and bar workers. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Reed, D.B., and Rayens, M.K. (July 2005). How do older farm residents define good health? Sigma Theta Tau International Nursing Research Congress, Waikoloa, Hawaii. Burkhart, P.V., Rayens, M.K., Oakley, M.G., and Ohlmann, A.B. (July 2006). Testing an intervention to promote children s adherence to recommended asthma self-management. Sigma Theta Tau International Research Congress, Montreal, Quebec. Hall, L.A., Peden, A.R., and Rayens, M.K. (July 2006). Correlates of health status in low-income mothers of young children. Sigma Theta Tau International Research Congress, Montreal, Quebec. Peden, A.R., Hall, L.A., and Rayens, M.K. (July 2006). Testing the effects of a cognitivebehavioral intervention on the physical and mental health status of low-income single mothers. Sigma Theta Tau International Research Congress, Montreal, Quebec. Svavarsdottir, E.K., Burkhart, P.V., Orlygsdottir, B., Rayens, M.K., and Westneat, S. (June 2007). Factors related to quality of life for adolescents with asthma and their parents. International Family Nursing Conference, Bangkok, Thailand. Rayens, M.K., Reed, D., and Zhang, M. (July 2007). Predictors of depressive symptoms in older rural couples: Actor-partner interdependence model. Sigma Theta Tau International Research Congress, Vienna, Austria. Burkhart, P.V., Rayens, M.K., and Oakley, M.G. (July 2007). Improved health outcomes with peak flow monitoring for children with asthma. Sigma Theta Tau International Research Congress, Vienna, Austria. Hall, L.A., Rayens, M.K., and Peden, A.R. (July 2007). The relationships of maternal smoking with maternal mental health and mothers reports of children s behavior problems. Sigma Theta Tau International Research Congress, Vienna, Austria

426 CURRICULUM VITAE Mary Kay Rayens, PhD Skärsäter, I., Rayens, M.K., Peden, A.R., Hall, L.A., and Zhang, M. (July 2007). Sense of coherence and recovery from depression. Sigma Theta Tau International Research Congress, Vienna, Austria. Hahn, E.J., Rayens, M.K., and Zhang, M. (July 2007). Effect of a smoke-free law on the community smoking rate. Sigma Theta Tau International Research Congress, Vienna, Austria. Peden, A.R., Rayens, M.K., Hall, L.A., Hahn, E.J., Riker, C.A., Ashford, K., and Zhang, M. (July 2007). A mental health intervention to help pregnant smokers quit. Sigma Theta Tau International Research Congress, Vienna, Austria. Butler, K.M., Maggio, L., Riker, C., Rayens, M.K., and Hahn, E. (September 2007). Tobacco use dependence treatment education and undergraduate nursing students. Nurse Education Tomorrow 2007 Conference, Cambridge, England. Skärsäter I., Rayens, M.K., Peden, A., Hall, L., Zhang, M., Agren, H., Prochazka, H. (March 2008). Sense of coherence and recovery from major depression: A four-year follow-up. International Society of Affective Disorders Conference, Cape Town, South Africa. National Hall, L.A., Sachs, B., Gurley, D.N., Kryscio, R.J., O Neill, M.K., and Pietrukowicz, M. (November 1990). Maternal depression, parenting and child health: A longitudinal study of singlemother families. National Council on Family Relations 1990 Conference, Seattle, WA. Hall, L.A., Sachs, B., O Neill, M.K., and Lutenbacher-Webne, M. (November 1991). Childhood maltreatment and depressive symptoms in adulthood. American Public Health Association 119 th Annual Meeting, Atlanta, GA. Rayens, M.K. and Kryscio, R.J. (July 1992). A note on the null distribution of Tango s index for detecting clustering in time. Statistics and Computing in Disease Clustering Workshop, Stony Brook, NY. Hahn, E.J., Rayens, M.K., Toumey, C., and McCoy, C. (October 1998). Building consensus with decision makers in Kentucky. National Conference on Tobacco and Health, St. Paul, MN. Hahn, E.J., Warnick, T., and Rayens, M.K. (November 2000). Tobacco control policy in the public and private sectors: Evaluation and surveillance issues. American Public Health Association 128 th Annual Meeting, Boston, MA. Hahn, E.J., Rayens, M.K., Okoli, T.C. (November 2002). Assessing workplace tobacco policies: A community-academic partnership. American Public Health Association 130 th Annual Meeting, Philadelphia, PA. Hahn, E.J., Rayens, M.K., Warnick, T.A., Christie, D., Greathouse, L. (November 2002). Population-based cessation: Outcomes of a Quit and Win contest National Conference on Tobacco or Health, San Francisco, CA

427 CURRICULUM VITAE Mary Kay Rayens, PhD Staten, R.R., Miller, K.H., Noland, M.P. and Rayens, M.K. (April 2003). An application of an ecological model to understanding physical activity and dietary behaviors among college students AAHPERD National Convention and Exposition, Philadelphia, PA. Hahn, E.J., Rayens, M.K., and Okoli, C.T.C. (November 2003). Restaurant and bar worker exposure to secondhand smoke in different policy environments. 131 st Annual Meeting of the American Public Heath Association, San Francisco, CA. Peden, A.R., Hall, L.A., and Rayens, M.K. (October 2004). Preventing depression in low-income single mothers. National Congress on the State of the Science in Nursing Research, Washington, DC. Okoli, C.T.C., Hahn, E.J., Riker, C.A., and Rayens, M.K. (November 2004). School tobacco policies in a tobacco growing state. American Public Health Association 132 st Annual Meeting, Washington, DC. Hahn, E.J., Thompson, E., Rayens, M.K., Blomquist, G., Garen, J., and Mullineaux, D.J. (May 2005). Smoke-free laws and employee turnover. National Conference on Tobacco or Health, Chicago, IL. Rayens, M.K., and Hahn, E.J. (July 2005). Mental health and readiness to quit smoking: A study of rural adults in Kentucky. Paper presented as part of the symposium Rural mental health: Issues across the lifespan, organized by McColloch, B.J. The Clock is Ticking for Rural America: A Behavioral Health and Safety Conference, Bloomington, MN. Peden, A.R., Rayens, M.K., and Reed, D.B. (July 2005). Depressive symptoms in adolescents living in Rural America. Paper presented as part of the symposium Rural mental health: Issues across the lifespan, organized by McColloch, B.J. The Clock is Ticking for Rural America: A Behavioral Health and Safety Conference, Bloomington, MN. Burkhart, P.V., Rayens, M.K., and Revelette, R. (March 2006). Asthma outcomes improve with peak flow monitoring. American Academy of Allergy, Asthma and Immunology Conference, Miami Beach, FL. Reed, D.B. and Rayens, M.K. (May 2007). Senior farm residents link ability to work to their definition of health. National Rural Health Association Conference, Anchorage, AK. Reed, D.B. and Rayens, M.K. (June, 2007). Predictors of Depressive Symptoms in Older Farm Couples: Actor-Partner Interaction Model. National Institute for Farm Safety Annual Conference, British Columbia, Canada. Hahn, E.J., Rayens, M.K., Hatcher, J., and Zhang, M. (November 2007). Motivation to quit smoking among relatives of lung cancer patients. American Public Health Association 135 th Annual Meeting, Washington, DC

428 CURRICULUM VITAE Mary Kay Rayens, PhD Hahn, E.J., Rayens, M.K., Langley, R.E., and Dignan, M. (November 2007). Differential effects of smoke-free laws on smoking cessation behavior. American Public Health Association 135 th Annual Meeting, Washington, DC. Regional Lutenbacher, M., Hall, L.A., Sachs, B., and Rayens, M.K. (February 1993). Psychometric examination of the CES-D scale: A secondary analysis. Southern Research Society Annual Conference, Birmingham, AL. Hall, L.A., Sachs, B., and Rayens, M.K. (February 1995). Mothers potential for child abuse: The roles of childhood abuse and current social resources Southern Nursing Research Society Annual Conference, Lexington, KY. Peden, A.R., Hall, L.A., Payne, L., and Rayens, M.K. (February 1998). Prevalence and correlates of depressive symptoms in college women. Southern Nursing Research Society Annual Conference, Fort Worth, TX. Peden, A.R., Hall, L.A., Rayens, M.K. and Beebe, L.L. (February 1999). Prevention of depression in college women: Testing an intervention. Southern Nursing Research Society Annual Conference, Charleston, SC. Hahn, E.J., Hall, L.A., Rayens, M.K., Burt, A.V., Flathman, O., Corley, D., Sheffel, K. (February 1999). Kindergarten children s knowledge of alcohol, tobacco, and other drugs. Southern Nursing Research Society Annual Conference, Charleston, SC. Peden, A.R., Hall, L.A., and Rayens, M.K. (February 2000). The quality of primary intimate relationships in college women: Effects on Depression. Southern Nursing Research Society Annual Conference, Little Rock, AK. Kulig, J.C., Lock, S.E., Stanhope, M., and Rayens, M.K. (February 2000). Determining healthy behaviors among elementary populations. Southern Nursing Research Society Annual Conference, Little Rock, AK. Hall, L.A., Peden, A.R., and Rayens, M.K. (February 2002). The effect of intimate relationships on the mental health of college women, part of a symposium organized by R. Staten entitled Creating a healthier future: Prevention research with college students. Southern Nursing Research Society Annual Conference, San Antonio, TX. Svavarsdottir, E.K. and Rayens, M.K. (March 2002). Childhood chronic asthma: How Icelandic and American families perceive the health status of their young child. Midwest Nursing Research Society Annual Conference, Chicago, IL. Barnes, S.L., Kearney, P., Boulanger, B., Bernard, A., Tsuei, B., and Rayens, M.K. (December 2002). Trauma attending presence in the resuscitation room does not affect outcome in severe trauma. Southern Surgical Association Conference, Palm Beach, FL

429 CURRICULUM VITAE Mary Kay Rayens, PhD Hahn, E.J. and Rayens, M.K. (February 2003). Evaluation of a statewide population-based cessation contest, part of a symposium organized by E. Hahn entitled Tobacco cessation: Individuals, populations, and policies. Southern Nursing Research Society Annual Conference, Orlando, FL. Rayens, M.K. and Svavarsdottir, E.K. (February 2004). A new methodological approach in nursing research: An actor, partner and interaction effect model for family outcomes. Southern Nursing Research Society Annual Conference, Louisville, KY. Peden, A.R., Hall, L.A., Rayens, M.K. and Grant, E. (February 2004). Prevention of depression in low-income single mothers. Southern Nursing Research Society Annual Conference, Louisville, KY. Staten, R., Miller, K., Noland, M., and Rayens, M.K. (February 2004). The relationship of selfreported BMI to body image, physical activity, dietary behavior and selected demographics, part of a symposium organized by S. Barton entitled Obesity in Infancy, Childhood, and Adolescence. Southern Nursing Research Society Annual Conference, Louisville, KY. Hahn, E.J. and Rayens, M.K. (February 2004). Effectiveness of a Quit and Win contest with a low income population. Southern Nursing Research Society Annual Conference, Louisville, KY. Svavarsdottir, E.K. and Rayens, M.K. (March 2004). An actor and a partner effect on family hardiness: Icelandic and American families of young children with asthma. Midwest Nursing Research Society Annual Conference, St. Louis, MO. Okoli, C.T.C., Hahn, E.J., and Rayens, M.K. (February 2005). Exposure to secondhand smoke and nicotine dependence, part of a symposium organized by E. Hahn entitled Secondhand tobacco smoke: Protecting the most vulnerable. Southern Nursing Research Society Annual Conference, Atlanta, GA. Okoli, C.T., Hahn, E.J., Al-Delaimy, W., and Rayens, M.K. (February 2005). Hair nicotine as a biomarker for exposure to secondhand smoke, part of a symposium organized by E. Hahn entitled Secondhand tobacco smoke: Protecting the most vulnerable. Southern Nursing Research Society Annual Conference, Atlanta, GA. Hahn, E.J., Hurt, Y.R., Rasnake, R.T., Rayens, M.K., and Al-Delaimy, W.K. (February 2005). Secondhand smoke exposure in restaurant and bar workers, part of a symposium organized by Ellen Hahn entitled Secondhand tobacco smoke: Protecting the most vulnerable. Southern Nursing Research Society Annual Conference, Atlanta, GA. Peden, A.R., Hall, L.A., and Rayens, M.K. (February 2005). Improving the mental health of lowincome single mothers: A 12-month longitudinal study. Southern Nursing Research Society Annual Conference, Atlanta, GA. Hall, L.A., Rayens, M.K., and Peden, A.R. (February 2005). Maternal factors associated with child behavior: Testing a proposed model. Southern Nursing Research Society Annual Conference, Atlanta, GA

430 CURRICULUM VITAE Mary Kay Rayens, PhD Rayens, M.K., and Hahn, E.J. (February 2006). Social support, depressive symptoms, stressful life events and the ability to quit smoking. Southern Nursing Research Society Annual Conference, Memphis, TN. Burkhart, P.V., Oakley, M.G., Rayens, M.K., Bowman, R.K., Knox, C.A., Abshire, D.A., Zhang, M., and Revelette, W.R. (February 2006). Promoting children s adherence to asthma selfmanagement. Southern Nursing Research Society Annual Conference, Memphis, TN. Peden, A.R., Hall, L.A., and Rayens, M.K. (February 2006). Use of alcohol and tobacco and the mental and physical health of low-income single mothers. Southern Nursing Research Society Annual Conference, Memphis, TN. Rayens, M.K., Moser, D., and Riegel, B. (February 2007). A new methodology for nursing research: Propensity score analysis. Southern Nursing Research Society Annual Conference, Galveston, TX. Burkhart, P., Rayens, M.K., and Oakley, M. (February 2007). Is peak flow monitoring effective in improving health outcomes for children with asthma? Southern Nursing Research Society Annual Conference, Galveston, TX. Hahn, E.J., Burkhart, P., Moser, D., Rayens, M.K., and Lee, S. (February 2007). Effect of a smokefree law on asthma and cardiac events. Southern Nursing Research Society Annual Conference, Galveston, TX. Peden, A., Rayens, M.K., and Hall, L. (February 2007). Predictors of the physical health status of low-income mothers of young children. Southern Nursing Research Society Annual Conference, Galveston, TX. Moser, D., Chung, M., Riegel, B., Rayens, M.K., and Lennie, T. (February 2007). Nonadherence is a mediator of the link between depressive symptoms, and rehospitalization or mortality in patients with heart failure. Southern Nursing Research Society Annual Conference, Galveston, TX. Hall, L.A., Peden, A.R., and Rayens, M.K. (February 2008). STOP: An intervention that decreases negative thinking, part of a symposium organized by A. Peden entitled Cognitive-behavioral strategies: The body of evidence grows. Southern Nursing Research Society Annual Conference, Birmingham, AL. Hahn, E.J., Peden, A.R., Rayens, M.K., Hall, L.A., and Ashford, K. (February 2008). Smoking during and after pregnancy: A cognitive-behavioral intervention for tobacco treatment, part of a symposium organized by A. Peden entitled Cognitive-behavioral strategies: The body of evidence grows. Southern Nursing Research Society Annual Conference, Birmingham, AL. Rayens, M.K., Hahn, E.J., Langley, R.E., and Zhang, M. (February 2008). Public support for smoke-free laws in Kentucky: Differences between urban and rural residents. Southern Nursing Research Society Annual Conference, Birmingham, AL

431 CURRICULUM VITAE Mary Kay Rayens, PhD Butler, K.M., Hahn, E.J., and Rayens, M.K. (February 2008). Preparing future nurses for tobacco dependence treatment. Southern Nursing Research Society Annual Conference, Birmingham, AL. Burkhart, P.V., Rayens, M.K., and Oakley, M.G. (February 2008). Improved asthma quality of life for children participating in a self-management program. Southern Nursing Research Society Annual Conference, Birmingham, AL. Chung, M., Lennie, T., Moser, D., and Rayens, M.K. (February 2008). The effects of depressive symptoms and anxiety on quality of life: Testing dyadic dynamic using Actor-Partner Interdependence Model. Southern Nursing Research Society Annual Conference, Birmingham, AL. Hahn, E.J., Rayens, M.K., and Hatcher, J. (February 2008). Telephone interview and efficacy of Quit and Win Contests. Southern Nursing Research Society Annual Conference, Birmingham, AL. State Rayens, M.K. (March 1993). Properties of Tango s index for detecting clustering in time. Ninth Annual Eastern Kentucky University Symposium in the Mathematical, Statistical, and Computer Sciences, Richmond, KY. Local Sachs, B., Hall, L., Lutenbacher, M., and Rayens, M.K. (April 1995). Rural low birthweight children and their mothers. Research Papers Day, Delta Psi Chapter, Sigma Theta Tau International, Lexington, KY. Hahn, E.J., Rayens, M.K., Toumey, C.P., and McCoy, C.A. (October 1998). Rural legislators views on tobacco control and health policy. University of Kentucky Rural Health Research Colloquium, Lexington, KY. Hahn, E.J., Rayens, M.K., and Plymale, M. (January 2001). Findings from the Kentucky Youth Tobacco Survey University of Kentucky College of Nursing Research Seminar Series, Lexington, KY. Hahn, E.J. and Rayens, M.K. (September 2002). Population-based cessation: Outcomes of a Quit and Win contest. University of Kentucky School of Public Health Grand Rounds Seminar Series, Lexington, KY. Hahn, E.J. and Rayens, M.K. (September 2002). Population-based cessation: Outcomes of a Quit and Win contest. University of Kentucky College of Nursing Seminar Series, Lexington, KY. Staten, R. R., Rayens, M. K., Hahn, E. J., Noland, M., Ridner, L. (October 2002). Social Influences on tobacco using and non-using college students. Prevention Research Center Seminar, Lexington, KY

432 CURRICULUM VITAE Mary Kay Rayens, PhD Staten, R.R., Noland, M.P., Miller, K.H., and Rayens, M.K. (September 2003). An ecological model of nutrition and physical activity in college students. UK College of Nursing Seminar Series, Lexington, KY. Staten, R., Hahn, E., Rayens, M.K., Noland, M., and Ridner, L. (November 2003). Social influences on tobacco using and non-using college students. UK Public Health Grand Rounds Series, Lexington, KY. Reed, D.R., Claunch, D., Rayens, M.K., and Slusher, D. (September 2004). Evaluation of community-based farm safety education for children. University of Kentucky College of Nursing seminar: Symposium of papers by UK College of Nursing faculty presented at the Sigma Theta Tau International Nursing Research Congress in Dublin. Rayens, M.K., Hall, L.A., Peden, A.R., Hahn, E.J., and Reed, D. (September 2004). Factor structure of the Center for Epidemiologic Studies Depression Scale: A study of women across the life span. University of Kentucky College of Nursing seminar: Symposium of papers by UK College of Nursing faculty presented at the Sigma Theta Tau International Nursing Research Congress in Dublin. Peden, A.R., Hall, L.A., and Rayens, M.K. (September 2004). Prevention of depression in lowincome single mothers. University of Kentucky College of Nursing seminar: Symposium of papers by UK College of Nursing faculty presented at the Sigma Theta Tau International Nursing Research Congress in Dublin. Hahn, E.J., Rayens, M.K., and Okoli, C. (September 2004). Secondhand tobacco smoke exposure among restaurant and bar workers. University of Kentucky College of Nursing seminar: Symposium of papers by UK College of Nursing faculty presented at the Sigma Theta Tau International Nursing Research Congress in Dublin. Okoli, C., Hahn, E., Hall, L., and Rayens, M.K. (March 2005). Hair nicotine as a biomarker for exposure to secondhand smoke. University of Kentucky College of Nursing Student Scholarship Showcase. Rayens, M.K., and Hahn, E.J. (September 2005). Mental Health and Readiness to Quit Smoking: A Study of Rural Adults in Kentucky. Presented as part of the College of Nursing Seminar Series. Peden, A.R., Rayens, M.K., and Reed, D.B. (September 2005). Depressive Symptoms in Adolescents Living in Rural America. Presented as part of the College of Nursing Seminar Series. Hahn, E. J., Burkhart, P.V., Rayens, M.K., Lee, S., and Moser, D.K. (June 2006). Smoke-free Laws and Asthma Outcomes. First Annual Clinical and Translational Science Spring Conference, Lexington, KY. Hahn, E., Riker, C., Rayens, M.K., and Liu, Y. (November 2006). Joys and challenges of preparing an international research grant application: Smoke-free policy development in China. UK College of Nursing Seminar Series, Lexington, KY

433 CURRICULUM VITAE Mary Kay Rayens, PhD Rayens, M.K., Reed, D.B., and Zhang, M. (September 2007). Predictors of Depressive Symptoms in Older Rural Couples: Actor-Partner Interdependence Model. UK College of Nursing Seminar Series, Lexington, KY. Poster Presentations Lutenbacher-Webne, M., Hall, L.A., O Neill, M.K., and Sachs, B. (February 1992). Psychosomatic symptoms, parenting attitudes, and child behavior in single-mother families: A secondary analysis of data. Southern Nursing Research Society Annual Conference, Nashville, TN. Greiner, P., Hall, L.A., O Neill, M.K., and Sachs, B. (February 1992). Psychosocial predictors of functional health, parenting attitudes, and child behavior in single-parent families: A secondary analysis of data. Southern Nursing Research Society Annual Conference, Nashville, TN. Satterly, C.M., Hall, L.A., Sachs, B., and Rayens, M.K. (February 1993). Psychometric evaluation of the Family Function Questionnaire: Preliminary findings. Southern Nursing Research Society Annual Conference, Birmingham, AL. Carpenter, J., Andrykowski, M., Wilson, J., Hall, L., Rayens, M.K., Sachs, B., and Cunningham, L. (February 1998). Psychometrics for two short forms of the Center for Epidemiologic Studies Depression Scale (CES-D). Southern Nursing Research Society Annual Conference, Fort Worth, TX. Hahn, E.J., Rayens, M.K., Toumey, C. and McCoy, C. (November 1998). Kentucky legislators views on tobacco. American Public Health Association Conference, Washington, DC. Hahn, E.J., Rayens, M.K., and Warnick, T.A. (November 1999). Progress in restaurant smoking policy: Creation of a statewide food service establishment data base. American Public Health Association Conference, Chicago, IL. Hahn, E.J., Warnick, T.A., Rayens, M.K., and Love, K. (November 1999). Monitoring workplace smoking policies. American Public Health Association Conference, Chicago, IL. Peden, A.R., Hall, L.A., Rayens, M.K., and Shawler, C. (June 2001). Prevention of depression in low-income single mothers. International Congress of Nursing, 22 nd Quadrennial Congress, Copenhagen, Denmark. Hall, L.A., Peden, A.R., Rayens, M.K., and Shawler, C. (June 2001). Correlates of maternal perception of child behavior in low-income single mothers of young children. Sigma Theta Tau 12 th International Congress, Copenhagen, Denmark. Hahn, E.J., Warnick, T., Rayens, M.K., Greathouse, L. and Rasnake, R. (November 2001). Evaluation of a multi-component, population-based cessation contest with a disparate population. National Conference on Tobacco or Health, New Orleans, LA

434 CURRICULUM VITAE Mary Kay Rayens, PhD Hendrix, J.M., Hicks, E.P., Rayens, M.K., Hansen, B.R. and Beeman, C.S. (March 2002). Relationships between cervical vertebrae and mandibular canine development stages for skeletal maturation evaluation. International Association of Dental Research Meetings, San Diego, CA. Chen, F.C., Beeman, C.S., Hicks, E.P., and Rayens, M.K. (March 2002). The prevalence of hypodontia in rural southeast Kentucky Appalachian Region. International Association of Dental Research Meetings, San Diego, CA. Hahn, E.J., Rayens, M.K., Warnick, T.A., Christie, D., Greathouse, L. (November 2002). Evaluation of a statewide, population-based cessation contest. American Public Health Association, Philadelphia, PA. Staten, R. R., Rayens, M. K., Hahn, E. J., Noland, M., Ridner, L. (November 2002). Social influences on tobacco using and non-using college students. Department of Education Higher Education Center on Alcohol and Other Drug Abuse and Violence Annual Meeting, Seattle, WA. DeLetter, M., Berger, R., Boosalis, M., Rayens, M.K., and Harthill, M. (February 2003). Nutritional and metabolic changes in persons with chronic airflow limitation. Southern Nursing Research Society Annual Conference, Orlando, FL. Peden, A.R., Hall, L.A., Rayens, M.K., and Grant, E. (February 2003). The mental health of lowincome single mothers and its effects on their children. Southern Nursing Research Society Annual Conference, Orlando, FL. Cherubini, M.L., Ebersole, J.L., Hicks, E.P., and Rayens, M.K. (March 2003). Rofecoxib, a cyclooxygenase-2 inhibitor, and its analgesic efficacy in orthodontically induced pain: A randomized controlled trial. American Association of Orthodontics Conference, Honolulu, HI. Cherubini, M.L., Ebersole, J.L., Hicks, E.P., and Rayens, M.K. (June 2003). Rofecoxib, a cyclooxygenase-2 inhibitor, and its analgesic efficacy in orthodontically induced pain: A randomized controlled trial. International Association of Dental Research, Goteborg, Sweden. Peden, A.R., Reed, D.B., and Rayens, M.K. (October 2003). Mental health of rural adolescents. 17th Annual Meeting of the American Psychiatric Nurses Association, Atlanta, GA. Reed, D.R., Rayens, M.K., and Daniel, D. (October 2003). How are they faring in the field: First report of a 5 year study of farmers over 50. The Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities: Fifth International Symposium, Saskatoon, SK, Canada. Claunch, D., Reed, D. B, Rayens, M. K., Burgus, S., and Slusher, D. (October 2003). FS4JK day camps: Who learns the most? The Future of Rural Peoples: Rural Economy, Healthy People, Environment, Rural Communities: Fifth International Symposium, Saskatoon, SK, Canada

435 CURRICULUM VITAE Mary Kay Rayens, PhD Charoensuk, S., Hall, L.A., Rayens, M.K., and Peden, A.R. (February 2004). Psychometric properties of the CES-D and the BDI in a single mother population. Southern Nursing Research Society Annual Conference, Louisville, KY. Hahn, E.J., Moser, D., Burkhart, P., and Rayens, M.K. (May 2004). Reducing secondhand tobacco smoke: Cardiac and asthma outcomes. Flight Attendants Medical Research Institute Symposium, Miami Beach, FL. Rayens, M.K., Hall, L.A., and Peden, A.R. (July 2004). Mother-daughter bond: Influence on parenting the next generation. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Hall, L.A., Peden, A.R., and Rayens, M.K. (July 2004). The effect of a cognitive-behavioral intervention on mothers perception of their children s behavior. Sigma Theta Tau International Nursing Research Congress, Dublin, Ireland. Hall, L.A., Peden, A.R., and Rayens, M.K. (October 2004). Effect of a cognitive-behavioral intervention on mothers perceptions of child behavior. National Congress on the State of the Science in Nursing Research, Washington, DC. Hahn, E.J., Moser, D.K., Burkhart, P.V., Rayens, M.K., and York, N.L. (October 2004). Reducing secondhand tobacco smoke: Cardiac and asthma outcomes. International Society for the Prevention of Tobacco Induced Diseases, Louisville, KY. Hahn, E.J., Rayens, M.K., Christie, D.M., Greathouse, L.W., and York, N.L. (October 2004). Evaluation of a statewide population-based cessation contest. International Society for the Prevention of Tobacco Induced Diseases, Louisville, KY. DeLetter, M., Boosalis, M., Berger, R., and Rayens, M.K. (October 2004). Effect of chronic airflow limitation on nutritional, metabolic, and functional status. National Congress on the State of the Science in Nursing Research, Washington, DC. Hahn, E.J., Thompson, E., Rayens, M.K., Mullineaux, D.J., Blomquist, G.C., and Garen, J.E. (December 2004). Smoke-free laws & employee turnover. Robert Wood Johnson Foundation Substance Abuse Prevention Research Program, Charleston, SC. York, N.L., Hahn, E.J., and Rayens, M.K. (February 2005). Smoke-Free Laws and Voluntary Tobacco Policies in Manufacturing Facilities. Southern Nursing Research Society Annual Conference, Atlanta, GA. Vinson, J., Staten, R., and Rayens, M.K. (February 2005). The factors associated with attempts to decrease or stop alcohol and/or drug use by college undergraduates. Southern Nursing Research Society Annual Conference, Atlanta, GA. Charoensuk, S., Peden, A.R., Hall, L.A., and Rayens, M.K. (February 2005). Factors influencing depression in Thai adolescents. Southern Nursing Research Society Annual Conference, Atlanta, GA

436 CURRICULUM VITAE Mary Kay Rayens, PhD York, N., Hahn, E.J., and Rayens, M.K. (May 2005). Voluntary policy change in manufacturing facilities following introduction and enactment of a smoke-free ordinance. National Conference on Tobacco or Health, Chicago, IL. Chaowiang, K., Staten, R., Rayens, M.K., and Peden, A. (February 2006). Factors Influencing on General Well-Being in College Students. Southern Nursing Research Society Annual Conference, Memphis, TN. Adams, S., Peden, A.R., Hall, L.A., and Rayens, M.K. (February 2006). The Relationship of Childhood Physical and Sexual Abuse with Negative Thinking and Depressive Symptoms in Adulthood. Southern Nursing Research Society Annual Conference, Memphis, TN. Hatcher, J., Hall, L.A., Peden, A.R., and Rayens, M.K. (February 2006). Predictors of Depressive Symptoms in Low-Income African American Single Mothers. Southern Nursing Research Society Annual Conference, Memphis, TN. Hahn, E.J., Peden, A.R., Hall, L.A., Riker, C.A., Rayens, M.K., and Ashford, K. (February 2006). A Mental Health Intervention to Help Pregnant Smokers Quit. Southern Nursing Research Society Annual Conference, Memphis, TN. Hall, L.A., Peden, A.R., and Rayens, M.K. (February 2006). The Effects of Employment on the Mental Health of Low-Income Single Mothers, part of the symposter entitled Health Outcomes in Work-Life. Southern Nursing Research Society Annual Conference, Memphis, TN. Hahn, E.J., Rayens, M.K., Okoli, C., and Al-Delaimy, W. (February 2006). Effects of a Smoke- Free Law on Restaurant and Bar Workers Exposure to Secondhand Tobacco Smoke, part of the symposter entitled Health Outcomes in Work-Life. Southern Nursing Research Society Annual Conference, Memphis, TN. Reed, D.B. and Rayens, M.K. (February 2006). Physical and Mental Health of Older Farmers, part of the symposter entitled Health Outcomes in Work-Life. Southern Nursing Research Society Annual Conference, Memphis, TN. Hahn, E.J., Burkhart, P.V., Rayens, M.K., Moser, D., and Lee, S (March 2006). Smoke-Free Laws and Asthma Outcomes. American Academy of Allergy, Asthma and Immunology Conference, Miami Beach, FL. Rayens, M.K. and Hahn, E.J. (June 2006). Social Support, Depressive Symptoms, Stressful Life Events and the Ability to Quit Smoking. First Annual Clinical and Translational Science Spring Conference, Lexington, KY. Hahn, E.J., Rayens, M.K., Lee, S., Burkhart, P. and Moser, D. (July 2006). Smoke-free laws and acute asthma and cardiac outcomes. Thirteenth World Conference on Tobacco or Health, Washington, DC

437 CURRICULUM VITAE Mary Kay Rayens, PhD Hahn, E.J., Thompson, E.C., Rayens, M.K., Blomquist, G.C., Garen, J.E., and Mullineaux, D.J. (July 2006). Effect of smoke-free laws on turnover in a large national restaurant chain. Thirteenth World Conference on Tobacco or Health, Washington, DC. Okoli, C.T.C, Hahn, E.J., and Rayens, M.K. (July 2006). Behavioral effects of nicotine exposure from secondhand smoke among restaurant and bar workers. Thirteenth World Conference on Tobacco or Health, Washington, DC. Ashford, K., Hahn, E., Peden, A., Rayens, M.K., and Hall, L. (February 2007). Successful postpartum smoking abstinence. Southern Nursing Research Society Annual Conference, Galveston, TX. Smith, C., Lennie, T., Hall, L., Chung, M., Heo, S., Rayens, M.K., Riegel, B., and Moser, D. (February 2007). Testing the validity of a one-item quality of life assessment tool in heart failure. Southern Nursing Research Society Annual Conference, Galveston, TX. York, N., Hahn, E., Rayens, M.K., Anderson, D., and Talbert, J. (February 2007). Community readiness for smoke-free policy change in Kentucky. Southern Nursing Research Society Annual Conference, Galveston, TX. Ohlmann, A., Burkhart, P., Baumgardner, J., Svavarsdottir, E., Oakley, M., Orlygsdottir, B., Westneat, S., and Rayens, M.K. (February 2007). Factors related to asthma quality of life for U.S. and Icelandic adolescents. Southern Nursing Research Society Annual Conference, Galveston, TX. Hall, L., Rayens, M.K., and Peden, A. (February 2007). The mother-daughter bond during childhood and parenting the next generation. Southern Nursing Research Society Annual Conference, Galveston, TX. Adams, S., Rayens, M.K., Peden, A., Hall, L., and Leukefeld, C. (February 2007). Factors associated with retention of previously incarcerated women in a community-based substance abuse treatment programs. Southern Nursing Research Society Annual Conference, Galveston, TX. Parrish, E., Peden, A., Reed, D. and Rayens, M.K. (February 2007). Psychometric properties of the John Henryism scale in rural adolescents. Southern Nursing Research Society Annual Conference, Galveston, TX. Baumgardner, J., Ohlmann, A., Burkhart, P., Svavarsdottir, S., Oakley, M., Orlygsdottir, B., Westneat, S., and Rayens, M.K. (April 2007). Factors related to quality of life for U.S. and Icelandic adolescents with asthma. Showcase of Undergraduate Scholars, University of Kentucky, Lexington, KY. Svavarsdottir, E.K., Burkhart, P.V., Orlygsdottir, B., Rayens, M.K., and Westneat, S. (May 2007). Factors related to quality of life for adolescents with asthma and their parents. Royal College of Nursing Annual International Nursing Research Conference, Dundee, Scotland

438 CURRICULUM VITAE Mary Kay Rayens, PhD Rayens, M.K. and Hahn, E.J. (June 2007). Effects of a Quit and Win Tobacco Cessation Contest. Second Annual Clinical and Translational Science Spring Conference, Lexington, KY. Butler, K.M., Rayens, M.K., Maggio, L., Riker, C., & Hahn, E. (September 2007). Tobacco dependence treatment and healthcare workers. WorkLife2007: Protecting and Promoting Worker Health A National Symposium (NIOSH), Bethesda, MD. Reed, D.R., Rayens, M.K., Zhang, M., and Claunch, D.T. (September 2007). Health care delay of aging agriculture producers. WorkLife2007: Protecting and Promoting Worker Health A National Symposium (NIOSH), Bethesda, MD. Chung, M.L., Moser, D.K., and Rayens, M.K. (September 2007). The effects of depressive symptoms and anxiety on quality of life: Testing dyadic dynamics using the Actor-Partner Interdependence Model. Health Failure Society of America Annual Meeting, Washington, DC. Hahn, E.J., Rayens, M.K., Hatcher, J., Zhang, M. Motivation to quit smoking among relatives of lung cancer patients. (September 2007). Markey Cancer Center Research Day, Lexington, KY. Rayens, M.K., Hahn, E.J., Zhang, M., and Butler, K.M. (October 2007). Telephone interviews and efficacy of Quit and Win Contests National Conference on Tobacco or Health, Minneapolis, MN. Hahn, E.J., Rayens, M.K., Zhang, M., and Langley, R. (October 2007). Public support for smokefree laws: An urban versus rural comparison National Conference on Tobacco or Health, Minneapolis, MN. York, N.L., Hahn, E.J., and Rayens, M.K. (October 2007). Local elected officials views on smokefree policy National Conference on Tobacco or Health, Minneapolis, MN. York, N.L., Hahn, E.J., and Rayens, M.K. (October 2007). A novel approach to evaluating smokefree policy readiness National Conference on Tobacco or Health, Minneapolis, MN. Butler, K.M., Rayens, M.K., Maggio, L., Riker, C., & Hahn, E. (October 2007). Tobacco treatment training in nursing education: Live and learn National Conference on Tobacco or Health, Minneapolis, MN. Rayens, M.K., Hahn, E.J., Zhang, M., Butler, K., and Steinke, D. (November 2007). Effect of a smoke-free law on the community smoking rate. American Public Health Association 135 th Annual Meeting, Washington, DC. Ashford, K., Hahn, E.J., Rayens, M.K., and Hall, L.A. (February 2008). Prenatal secondhand smoke exposure and birth outcomes. Southern Nursing Research Society Annual Conference, Birmingham, AL

439 CURRICULUM VITAE Mary Kay Rayens, PhD Chaowiang, K., Rayens, M.K., and Peden, A.R. (February 2008). Factors influencing depressive symptoms among Thai adolescents. Southern Nursing Research Society Annual Conference, Birmingham, AL. Durbin, E.G., Riker, C., Hahn, E.J., Cavendish, S., Zhang, M., and Rayens, M.K. (February 2008). Leadership and smoke-free policy development. Southern Nursing Research Society Annual Conference, Birmingham, AL. Hayes, G., Rayens, M.K., and Robertson, H. (February 2008). GIS mapping: Tobacco smoke, radon, and lung cancer. Southern Nursing Research Society Annual Conference, Birmingham, AL. Other Scholarly/Creative Productivity Rayens, M.K. and Tucker, T.C. (2000). Statistical Tools used in Applying Epidemiological Concepts to the Management of Healthcare Resources, Chapter 3 in the book Managerial Epidemiology (Editors: S.T. Fleming, F.D. Scutchfield, and T.C. Tucker), Health Administration Press, Chicago, IL. Martin, C.M., Guenthner, G., Bingcang, C., Smith, W.J., Curry, T., Omar, H.A., Rayens, M.K., and Kelly, T.H. (2007). Attention Deficit Hyperactivity Disorder and Pubertal Changes, Chapter 18 in the book Adolescent Behavior Research: International Perspectives (Editors: J. Merrick and H.A. Omar), Nova Science Publishers, Inc., New York. V. UNIVERSITY AND PUBLIC SERVICE Service That Supports Educational Mission of the University of Kentucky I have supervised and trained nine graduate students from the University of Kentucky Department of Statistics or University of Kentucky College of Nursing who were hired to provide biostatistical support in the Biostatistics Consulting Unit or the University of Kentucky College of Nursing College of Nursing representative on the Medical Center Academic Council Liaison to the Undergraduate Council from the Medical Center Academic Council 2007 Application reader for the William C. Parker Scholarship for University of Kentucky undergraduate students 2008 Application reader for the academic scholarships awarded by the University of Kentucky to incoming undergraduate students Member of the College of Nursing Governance Council Member of the College of Nursing PhD Program Committee

440 CURRICULUM VITAE Mary Kay Rayens, PhD Service That Supports the Research Mission of the University of Kentucky 1992 present I have consulted with many faculty members from the Colleges of Nursing, Medicine, Dentistry, Pharmacy, and Allied Health on the appropriate methods for planning and implementing the statistical aspects of their research. I have acted as a co-investigator, biostatistician, or consultant on a variety of sponsored projects and internally-funded grants. I have actively participated in grant and manuscript development with a wide array of faculty from all colleges in the Medical Center I participated in project selection as a member of the Children s Miracle Network grant review committee (October, 1998) As Associate Director of the Biostatistics Consulting Unit, I supervised a Master s level statistician whose primary job responsibility is to provide assistance to faculty developing grant proposals and graduate students working on theses or dissertations Member of Data Monitoring Board for the project The Menstrual Cycle and Cortisol Response in Chronic Fatigue Syndrome, (Mary Duke, Principal Investigator). Service to the Profession 2003 present Reviewer for the following journals: Research in Nursing & Health, American Journal of Preventive Medicine, American Journal of Health Promotion, Policy, Politics & Nursing Practice, Journal of the American Psychiatric Nurses Association, Health Psychology, and BMC Public Heath (part of the BioMed Central journal series) Abstract reviewer for the 2007 Southern Nursing Research Society Conference (June 2006) 2007 Abstract reviewer for the 2008 Southern Nursing Research Society Conference (June 2007) Service to the Public I have provided biostatistical consulting for several clients external to the University. Clients between 1998 and 2003 include Shriners Hospitals for Children in Lexington, Cardinal Hill Rehabilitation Hospital, Central Baptist Hospital, HealthScreenings, Inc., Kentucky Sports Medicine/Joyner Sportsmedicine Institute, University of Washington in Seattle, Kentucky Department of Education, Louisville Gas and Electric, and Appalachian Regional Healthcare

441 CURRICULUM VITAE Mary Kay Rayens, PhD VIII. ADMINISTRATIVE ACTIVITY AND PROFESSIONAL DEVELOPMENT Non-sponsored Administrative Activities I had a variety of administrative responsibilities as Associate Director of the Biostatistics Consulting Unit. These responsibilities included developing the annual budget for the Unit, providing monthly activity and billing reports to the Vice Chancellor for Research and Graduate Studies, setting policy for the Unit, and hiring/supervising Unit personnel present I supervise Mei Zhang, MPH, MSN, who works as a statistician for the UK College of Nursing. Membership in Professional Societies 1990 present American Statistical Association International Biometric Society East North American Region 2003 present Southern Nursing Research Society 2007 present American Public Health Association