LOW HANGING FRUITS: PROJECTS THAT ARE CANDIDATES FOR BEING PURSUED IMMEDIATELY

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1 S. No 1. (Semantic, Indian, Mining) Database crawler for Amyloid related info Peritoneal dialysis: risk factor analysis Project Objective Impact Confidence Remarks by Others 3 3 Develop a common mining tool for brain, liver,kidney..etc. to diagnosis the amyloid from data base analysis. 2. (Semantic, Indian, Mining) Database crawler for Amyloid related info Not sure if we have data mechanism or will the project generate this. 3. Generate a database of Diabetic patient characteristics, what treatment plans were tried, how they worked. This is to help semi-experts in remote areas. They will then be able to recognize complicated cases for referrals and treat the rest.) I could not get some endocrinologists to agree to give data in the past. A Colleague tried working on a similar project in the past and is partially successful though.

2 4. Building the top down approach starting from body level to the tissue level. The clinical data and the top level modeling can be integrated with the tissue and transport level modeling Developing a system to track the emotion of the AD patient and detect the comfort level in order to decide upon the music or games. Or to entertain/boost mood of the patient. 5 4 Surely do-able, will need and rely a lot on clinicians though 6. Develop training tools for facilitating clinicians or training health workers. Simulators for training nurses or health workers like haptic simulators or interactive animations with validated inputs 5 5 We see several possibilities with computer science based tools for facilitating OP. This, explicitly are not simulations but clinically relevant emulations/validated training tools such as games, virtual labs etc. However, results from such may be directed for clinical analysis especially reducing training time or field-work review time for case studies. -- 5,5 from our side]

3 7. Designing of cognitive batteries for the cognitive evaluation and assessment of AD patients in different languages and developing mechanism for automatic evaluation ,4 would be appropriate too but will depends on clinicians I would put both at 5 8. Identification of Cogn undeprinning of AD and designing Establishing a nationwide systematic epidemiological data collection nodal point on neurodegenerative disorders, Diabetes Melitus and Hepatitis for clinicians we know it exsists

4 10. Ensure uniformity of clinical investigatory facilities across all participating institutions NA NA I feel this is essential and extremly importanat 11. Estimating the state of AD severity at any govern time and alerting caregivers 12. Study and optimization of convection enhanced drug delivery to the brain (through micro-catheters) using CFD. Its advantages include by-passing the blood brain barrier, targetted distribution, minimization of side effects etc. Quantitative characterization by use of CFD will help eventual clinical application. 3 4

5 13. Continuum level modeling of protein aggregation which leads to build up of plaque. Establish material models for plaque and study mechanical behavior of plaque. 14. Transport of plaque through the circulatory system. Goes hand in hand in item 25. Model would involve interaction between plaque and blood (fluid structure interaction) and can help understand how plaque reaches different parts of the body. 15. Characterizing beta amyloid formation inducing protein: GSAP (gamma secretase activating protein) using X-Ray crystallography. The structure of this protein is not known so the mechanism has questions which are unsolved in this area. Studying molecular level mechanisms would reveal the pathway for the formation of mis-folded protein structures 5 5