OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone.
|
|
- Michael Cross
- 8 years ago
- Views:
Transcription
1 Title of the poster Authors Sheffield Cancer Research Centre University of Sheffield OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone. Dr Penelope Ottewell
2 Background ~7% patients with late stage breast cancer develop bone metastasis. This condition is considered incurable with patients surviving 2-3 years after initial diagnosis of bone involvement. Current treatments are palliative; patients receive chemotherapy to treat their tumours and anti-resoptive agents to control their bone disease. We have focused on optomising the use of anti-resorptive agents (zoledronic acid (ZOL) and OPG-Fc) to increase their anti-tumour properties.
3 Breast cancer bone metastasis Tumour cells arrive in bone Tumour cells are triggered to wake up Tumour cells grow quickly. and cause bone destruction Zoledronic acid/opg-fc Doxorubicin Bone derived tumour growth factors dormant Bone Osteoblastic factors Osteolytic factors
4 Effects of adding zoledronic acid to doxorubicin on breast cancer bone metastases 6 week female BALB/c nude mice n=1/group Experimental time line Day Day 7 Day 28 Inject dox, ZOL or (or control) dox and ZOL 1x per week Inoculate MDA-231 luc2 cells into the tail artery Inject 2mg/kg Dox and 1ug/kg ZOL Cull Experimental time line Day Day 7 Day 8 Day 28 Inject dox (or control) followed 24h later by zol (or control) 1x per week Inoculate MDA-231 luc2 cells into the tail artery Inject 2mg/kg dox Inject 1ug/kg ZOL Cull Ottewell et al Clin Can Res 28
5 Effects of doxorubicin and zoledronic acid on breast cancer growth in bone Figure 1 Zol Dox A. B. C. Histology uct µct X-ray Osteolytic lesion area (mm 2 ) * Zol Dox Dox & Zol * * Dox then Zol D. Dox and zol E. Tumour area (mm 2 ) * Dox then zol Zol Dox Dox & Zol Dox then Zol Sequential administration with Dox followed by ZOL significantly reduced MDA-MB-231 breast cancer cell growth in bone. Ottewell et al Clin Can Res 28
6 Clinical study design; AZURE Standard therapy 3,36 Breast Cancer Patients Stage II/III Countries Centres Patients UK Eire Australia Spain 8 17 Portugal 1 32 Thailand 2 25 Taiwan 2 13 R Standard therapy + Zoledronic acid 4 mg 6 doses 8 doses 5 doses Q3-4 weeks Q 3 months Q 6 months Months Zoledronic acid treatment duration 5 years Coleman et al. N Engl J Med 211; 365:
7 Analysis of relapse in bone; AZURE Bone metastasis as first recurrence Bone metastasis at any time Zoledronic acid Zoledronic acid Adjusted HR.78 95% CI: , P=.2 Adjusted HR.81 95% CI: , P=.22 Adding zoledronic acid to standard of care delayed bone metastases Coleman et al Lancet Oncology 214; 15(9):997-16
8 Disease free survival and menopausal status; AZURE ITT analysis - DFS >5 years post-menopausal No. at risk ZOL Adjusted HR.94 95% CI: , P=.298 Zoledronic acid N = events No. at risk Zoledronic acid provided significantly greater therapeutic benefit to post menopausal women, ZOL Zoledronic acid Adjusted HR.77 95% CI: N = events Coleman et al Lancet Oncology 214; 15(9):997-16
9 Emerging hypotheses from adjuvant trials Bisphosphonates predominantly reduce distant metastases rather than either local recurrence or contralateral disease Effects likely to be largest on bone recurrence Bisphosphonates only improve disease outcome in women who have low levels of reproductive hormones Established natural menopause Induced menopause at start of treatment Why do bisphosphonates specifically benefit patients with established menopause? Coleman RE SABCS 213 Abs S4-7 and Lancet in press
10 Modeling the pre-and post-menopausal bone environment in the laboratory 12 week female BALB/c nude mice n=5/group Experimental time line Day Day 7 Day 14 Day 21 Day 28 Day 35 Day 57 Ovariectomy/ ovariectomy N=35/group Cull N=5/group Cull N=5/group Cull N=5/group Cull N=5/group Cull N=5/group Cull N=5/group How does alter the bone environment over time: - Bone volume - Osteoclast activity (TRAP ELISA) - Osteoblast activity (P1NP ELISA) Ottewell et al Clin Can Res 214
11 Bone microenvironment different under preand post-menopausal conditions Baseline 8 weeks Ovariectomy reduces bone volume by increasing osteoclast induced bone resorption * Ottewell et al Clin Can Res 214
12 Effects of ovariectomy on tumour cell proliferation in bone 12-week old female BALB/c nude mice n=9/group Experimental time line Day Day 7 Day 56 Inoculate MDA-231 luc2 cells i.c. Ovariectomy/ ovariectomy Cull Ovariectomy Number of tumours per mouse In bone Outside bone * Overiectomy stimulates proliferation of MDA-MB-231 cells disseminated in bone Ottewell et al Clin Can Res 214
13 Summary/research question Mimicking the menopause with ovariectomy alters bone turnover. Ovariectomy stimulates proliferation of dormant breast cancer cells in bone. Can anti-resorptive agents prevent ovariectomy induced proliferation of breast cancer cells in bone? Do anti-resorptive agents have different anti-tumour effects in pre- and post- menopausal bone environments?
14 Effects of ZOL on normal bone Zol % bone in contact with osteoclasts *** Zol BV/TV% 6 *** 4 2 Zol Number of osteoblasts per mm bone Zol ZOL inhibits bone turnover by reducing osteoclastic resorption of bone Ottewell et al JNCI 28
15 Effects of ZOL on ovariectomy induced tumour growth and bone resorption 12-week old female BALB/c nude mice n=1/group (X2) Experimental time line Day Day 4 Day 7 Day 35 Inject zol/saline 1x per week Mice with tumours in bone (%) control Inoculate MDA-231 luc2 cells i.c. zol Ovariectomy/ ovariectomy control zol ZOL inhibits stimulated growth of disseminated breast cancer cells in bone but had no effect of spontaneous tumour development from these cells. * BV/TV (%) control con Cull zol ** control * zol zol con zol Ottewell et al Clin Can Res 214 **
16 Do other anti-resorptive agents prevent induced bone metastases? Denosumab in the clinic: Human specific monoclonal antibody that binds RANKL with high affinity blocking RANK/RANKL interactions essential for osteoclatogenesis. Superior to zoledronic acid for prevention of skeletal complecations in patients with breast cancer bone metastasis. OPG-Fc in the laboratory: Potent inhibitor of osteoclatioenesis that acts by preventing RANK/RANKL binding. We investigated the effects of inhibiting -induced bone resorption through targeting RANK/RANKL interactions in our in vivo model of disseminated breast cancer cells in bone.
17 BV/TV (%) Effects of OPG-Fc on bone Morphology TRAP Goldners Safranin O osteoclasts osteoblasts OPG-Fc OPG-Fc 25 *** TRAP (U/L) 1 5 * * OPG-Fc P1NP * OPG-Fc OPG-Fc OPG-Fc inhibits osteoclastic bone resorption and osteoblastic bone formation Ottewell et al Int J Can 215
18 Effects of OPG-Fc on growth of disseminated breast cancer cells in bone 12-week old female BALB/c nude mice n=7/group (X2) Day Day 4 Day 7 Day 35 Inject OPG-Fc/saline 1x per week Inoculate MDA-231 luc2 cells i.c. Ovariectomy/ ovariectomy Cull Saline Saline OPG-Fc OPG-Fc Mice with tumours (%) BIL / tumour (p/s) *** Bone Non-bone saline saline OPG-Fc OPG-Fc Bone Non-bone *** *** saline saline OPG-Fc OPG-Fc OPG-Fc inhibits ovariectomy induced proliferation of disseminated MDA- MB-231 breast cancer cells in bone. Ottewell et al Int J Can 215
19 Effects of OPG-Fc on tibiae of mice following tumour cell inoculation saline saline OPG-Fc OPG-Fc 4 3 ^^^ ^^^ BV/TV% 2 1 ** saline saline OPG-Fc OPG-Fc 15 ^ 4 TRAP (U/L) 1 5 *** *** Saline Saline OPG-Fc OPG-Fc P1NP ng/ml *** *** Saline Saline OPG-Fc OPG-Fc OPG-Fc inhibits ovariectomy induced bone resorption leading to a net increase in bone volume and decrease in bone cell activity. Ottewell et al Int J Can 215
20 Summary Bone derived growth factors Tumour cells arrive in bone Ovariectomy stimulates bone turnover Tumour cells are triggered to wake up Tumour cells grow quickly. and cause bone destruction Zoledronic Acid/OPGFc Bone derived tumour growth factors dormant Bone Osteoblastic factors Osteolytic factors
21 Conclusions Cellular mechanisms responsible for driving tumour growth are different in pre- (sham) and post menopausal () bone metastasis models. Osteoclast mediated mechanisms drive progression of disseminated tumour cells only in the post-menopausal model. Inhibition of osteoclast activity with ZOL or disruption of RANK/RANKL interactions following administration of OPG-Fc inhibits induced stimulation of dormant tumour cells in bone Our data support early intervention with anti-resorptive therapy in a low oestrogen environment to prevent development of bone metastases.
22 Acknowledgements University of Sheffield Prof. Ingunn Holen Dr. Ning Wang Mrs. Anne Fowles Dr. Colby Eaton Dr. Hannah Brown Ms. Orla Gallagher Garvan Institute of medical research Prof Peter Croucher
Thomas de los Reyes PGY 1 Department of Urologic Sciences University of British Columbia. Meet Mr. S
Thomas de los Reyes PGY 1 Department of Urologic Sciences University of British Columbia Meet Mr. S 74 M admitted for back pain X-ray: sclerotic lesions along spine PSA 800 Nuclear Medicine Bone Scan 1
More informationThe Effect of Myeloma Cells on Bone Metabolism is Heterogenous and Correlates with Underlying Genetic Lesions and Bone Disease In Vivo
The Effect of Myeloma Cells on Bone Metabolism is Heterogenous and Correlates with Underlying Genetic Lesions and Bone Disease In Vivo Deepika Kassen 1, Neil Rabin 1, Darren Lath 2, Peter Croucher 2 and
More informationPathophysiology of bone metastasis : how does it apply to pain treatment in palliative care? JP Vuillez, Grenoble, France
Pathophysiology of bone metastasis : how does it apply to pain treatment in palliative care? JP Vuillez, Grenoble, France Bone metastases 70 % of prostate and breast cancers 30 % of lung, bladder and thyroid
More informationNew approaches to breast cancer treatment
VOLUME 47, ISSUE 11, NOVEMBER 2011 New approaches to breast cancer treatment Diverse new approaches to the treatment of breast cancer were presented at the 2011 European Multidisciplinary Cancer Congress
More informationInteligentaj decidoj... Intelligente Entscheide bei der adjuvanten Therapie des Mammakarzinoms. Intelligent Questions?
Intelligente Entscheide bei der adjuvanten Therapie des Mammakarzinoms Stefan Aebi Universitätsspital Bern, Inselspital Klinik für Medizinische Onkologie und Brust /Tumorzentrum der Frauenklinik Inteligentaj
More informationEverolimus plus exemestane for second-line endocrine treatment of oestrogen receptor positive metastatic breast cancer
LONDON CANCER NEWS DRUGS GROUP RAPID REVIEW Everolimus plus exemestane for second-line endocrine treatment of oestrogen receptor positive metastatic breast cancer Everolimus plus exemestane for second-line
More informationPROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.
PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic
More informationGUIDELINES ADJUVANT SYSTEMIC BREAST CANCER
GUIDELINES ADJUVANT SYSTEMIC BREAST CANCER Author: Dr Susan O Reilly On behalf of the Breast CNG Written: December 2008 Agreed at CNG: June 2009 & June 2010 Review due: June 2011 Guidelines Adjuvant Systemic
More informationHow To Treat Mesothelioma With A Tumor Stem Cell Inhibitor
FAK INHIBITOR DEFACTINIB (VS-6063) TARGETS MESOTHELIOMA CANCER STEM CELLS Rationale for maintenance therapy after conventional therapy Jonathan Pachter, Ph.D. Vice President of Research, Verastem, Inc.
More informationDevelopment of Bone Metastases in Men With Prostate Cancer
Development of Bone Metastases in Men With Prostate Cancer Explore the Causes Understand the Consequences Natural History of Prostate Cancer Progression Many prostate tumors may become castrate-resistant
More informationAvastin in breast cancer: Summary of clinical data
Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading
More informationMULTIPLE MYELOMA. Dr Malkit S Riyat. MBChB, FRCPath(UK) Consultant Haematologist
MULTIPLE MYELOMA Dr Malkit S Riyat MBChB, FRCPath(UK) Consultant Haematologist Multiple myeloma is an incurable malignancy that arises from postgerminal centre, somatically hypermutated B cells.
More informationChemotherapy or Not? Anthracycline or Not? Taxane or Not? Does Density Matter? Chemotherapy in Luminal Breast Cancer: Choice of Regimen.
Chemotherapy in Luminal Breast Cancer: Choice of Regimen Andrew D. Seidman, MD Attending Physician Breast Cancer Medicine Service Memorial Sloan Kettering Cancer Center Professor of Medicine Weill Cornell
More informationCytotoxic and Biotherapies Credentialing Programme Module 2
Cytotoxic and Biotherapies Credentialing Programme Module 2 1. The Cell Cycle 2. Cancer Therapies 3. Adjunctive Therapies On completion of this module the RN will State the difference between a normal
More informationTreatment of Metastatic Breast Cancer: Endocrine Therapies. Robert W. Carlson, M.D. Professor of Medicine Stanford University
Treatment of Metastatic Breast Cancer: Endocrine Therapies Robert W. Carlson, M.D. Professor of Medicine Stanford University MDACC Experience with FAC in Chemotherapy-Naive MBC Greenberg et al, J Clin
More informationBone lesions due to metastatic disease undermine
Implications of Bone Metastases and the Benefits of Bone-Targeted Therapy Allan Lipton Several cancers, including those originating in the breast, prostate, and lung, exhibit a propensity to metastasize
More informationBisphosphonate therapy. osteonecrosis of the jaw
I overview Bisphosphonate therapy and osteonecrosis of the jaw Authors_Johannes D. Bähr, Prof. Dr Dr Peter Stoll & Dr Georg Bach, Germany _Introduction Fig. 1_Structural formula of pyrophosphate and basic
More informationCONTRACTING ORGANIZATION: University of Alabama at Birmingham Birmingham, AL 35294
AD Award Number: W81XWH-08-1-0030 TITLE: Regulation of Prostate Cancer Bone Metastasis by DKK1 PRINCIPAL INVESTIGATOR: Gregory A. Clines, M.D., Ph.D. CONTRACTING ORGANIZATION: University of Alabama at
More informationSAMO FoROMe Post-ESMO 2013 Breast Cancer
SAMO FoROMe Post-ESMO 2013 Breast Cancer Dr. med. Manuela Rabaglio Klinik und Poliklinik für Medizinische Onkologie Breast Cancer Track 300 Abstracts 142 Poster 11 Proffered paper 4 late breaking news
More informationArie Barlev, PharmD, MS; Xue Song, PhD; Boris Ivanov, MS; Vidya Setty, MPH, MBA; and Karen Chung, PharmD, MS
RESEARCH Payer Costs for Inpatient Treatment of Pathologic Fracture, Surgery to Bone, and Spinal Cord Compression Among Patients with Multiple Myeloma or Bone Metastasis Secondary to Prostate or Breast
More informationBefore, Frank's immune cells could
Before, Frank's immune cells could barely recognize a prostate cancer cell. Now, they are focused on it. Stimulate an immune response against advanced prostate cancer Extend median survival beyond 2 years
More informationBone Disease in Myeloma. St. Petersburg, Russia September 16, 2009
Bone Disease in Myeloma St. Petersburg, Russia September 16, 2009 Bi Brian G.M. GMDurie, M.D. MD Bone Disease in Myeloma Lytic Lesions Spike Bone Marrow Plasma Cells Collapse of Vertebrae Biology of Myeloma
More informationCLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15
Page: 1 of 6 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted
More informationBreast Cancer Update 2014 Prevention, Risk, and Treatment of Early Stage Breast Cancer. Kevin R. Fox, MD University of Pennsylvania
Breast Cancer Update 2014 Prevention, Risk, and Treatment of Early Stage Breast Cancer Kevin R. Fox, MD University of Pennsylvania Prevention of Breast Cancer Accepted treatments Tamoxifen (premenopausal
More informationCancer patients waiting for potentially live-saving treatments in UK
Cancer patients waiting for potentially live-saving treatments in UK 29 May 2005 UK patients are waiting too long for new treatments, according to a 'Dossier of Delay' compiled by information charity CancerBACUP.
More informationBone Disease in Myeloma
Bone Disease in Myeloma Washington, DC August 8, 2009 Brian G.M. Durie, M.D. Bone Disease in Myeloma Lytic Lesions Spike Bone Marrow Plasma Cells Collapse of Vertebrae Biology of Myeloma Vascular Cytokines
More informationPrior Authorization Guideline
Prior Authorization Guideline Guideline: PS Inj - Alimta Therapeutic Class: Antineoplastic Agents Therapeutic Sub-Class: Antifolates Client: PS Inj Approval Date: 8/2/2004 Revision Date: 12/5/2006 I. BENEFIT
More informationCytotoxic Therapy in Metastatic Breast Cancer
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Cytotoxic Therapy in Metastatic Breast Cancer Cytotoxic Therapy in Metastatic Breast Cancer Version 2002: von Minckwitz Versions
More informationOsteosarcoma: treatment beyond surgery
Osteosarcoma: treatment beyond surgery Eric Chow, DVM DACVS Sue Downing, DVM DACVIM-Oncology Providing the best quality care and service for the patient, the client, and the referring veterinarian. Osteosarcoma
More informationRecommendations for cross-sectional imaging in cancer management, Second edition
www.rcr.ac.uk Recommendations for cross-sectional imaging in cancer management, Second edition Breast cancer Faculty of Clinical Radiology www.rcr.ac.uk Contents Breast cancer 2 Clinical background 2 Who
More informationGuidance for the Management of Breast Cancer Treatment-Induced Bone Loss
Guidance for the Management of Breast Cancer Treatment-Induced Bone Loss A consensus position statement from a UK Expert Group Reviewed and supported by the National Osteoporosis Society (NOS), the National
More informationAvastin in breast cancer: Summary of clinical data
Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading
More informationNational Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.
Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under
More informationChing-Yao Yang, Yu-Wen Tien
Ching-Yao Yang, Yu-Wen Tien Division of General Surgery, Department of Surgery, National Taiwan University Hospital Oct-30-2010 Pancreatic NET have poorer prognosis when presence of liver metastases at
More informationMetastatic Breast Cancer 201. Carolyn B. Hendricks, MD October 29, 2011
Metastatic Breast Cancer 201 Carolyn B. Hendricks, MD October 29, 2011 Overview Is rebiopsy necessary at the time of recurrence or progression of disease? How dose a very aggressive treatment upfront compare
More informationLa Chemioterapia Adiuvante Dose-Dense. Lo studio GIM 2. Alessandra Fabi
La Chemioterapia Adiuvante Dose-Dense Lo studio GIM 2 Alessandra Fabi San Antonio Breast Cancer Symposium -December 10-14, 2013 GIM 2 study Epirubicin and Cyclophosphamide (EC) followed by Paclitaxel (T)
More informationBone Disease in Myeloma
Bone Disease in Myeloma Boston, Massachusetts Saturday, July 26, 2008 Brian G.M. Durie, M.D. Bone Disease in Myeloma Lytic Lesions Spike Bone Marrow Plasma Cells Collapse of Vertebrae Biology of Myeloma
More informationTHE CANCER STEM CELL INHIBITORS VS-6063 AND VS-5584 EXHIBIT SYNERGISTIC ANTICANCER ACTIVITY IN PRECLINICAL MODELS OF MESOTHELIOMA
THE CANCER STEM CELL INHIBITORS VS-6063 AND VS-5584 EXHIBIT SYNERGISTIC ANTICANCER ACTIVITY IN PRECLINICAL MODELS OF MESOTHELIOMA Mitchell Keegan, Ph.D. Vice President of Development, Verastem, Inc. 1
More informationStage I, II Non Small Cell Lung Cancer
Stage I, II Non Small Cell Lung Cancer Best Results T1 (less 3 cm) N0 80% 5 year survival No Role Adjuvant Chemotherapy Radiation Therapy Reduces Local Recurrence No Improvement in Survival 1 Staging Mediastinal
More informationMedical Oncology. Rotation Goals & Objectives for rotating residents. General Objectives THE UNIVERSITY OF BRITISH COLUMBIA
THE UNIVERSITY OF BRITISH COLUMBIA Department of Urologic Sciences Faculty of Medicine Gordon & Leslie Diamond Health Care Centre Level 6, 2775 Laurel Street Vancouver, BC, Canada V5Z 1M9 Tel: (604) 875-4301
More informationCancer Related Issues: Bone Metastases
Cancer Related Issues: Bone Metastases Bronwyn Long, RN, DNP, ACHPN, AOCNS Updated from Hawkins, R. Cancer Related Issues: Bone Metastasis. Pittsburgh, PA: Hospice and Palliative Nurses Association; 2010:
More informationtrastuzumab, 600mg/5mL solution for injection (Herceptin ) SMC No. (928/13) Roche Products Ltd
trastuzumab, 600mg/5mL solution for injection (Herceptin ) SMC No. (928/13) Roche Products Ltd 06 December 2013 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product
More informationDECISION AND SUMMARY OF RATIONALE
DECISION AND SUMMARY OF RATIONALE Indication under consideration Clinical evidence Everolimus in combination with exemestane hormone therapy for oestrogen receptor positive locally advanced or metastatic
More informationAdjuvant Endocrine Therapy in Breast Cancer: 2015 Update
Adjuvant Endocrine Therapy in Breast Cancer: 2015 Update Shannon Puhalla, MD Director, Breast Cancer Clinical Research Program Magee Womens Cancer Program University of Pittsburgh Cancer Institute Questions
More information18.5 Percent Overall Response Rate Observed in Pembrolizumab-Treated Patients with this Aggressive Form of Breast Cancer
News Release Media Contacts: Annick Robinson Investor Contacts: Joseph Romanelli (514) 837-2550 (908) 740-1986 Stephanie Lyttle NATIONAL Public Relations (514) 843-2365 Justin Holko (908) 740-1879 Merck
More informationTargeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma
The Use of Kinase Inhibitors: Translational Lab Results Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma Sheelu Varghese, Ph.D. H. Richard Alexander, M.D.
More informationTheories on Metastasis: Innovative Thinking An Advocacy Perspective
Theories on Metastasis: Innovative Thinking An Advocacy Perspective Project LEAD Workshop NBCC Annual Advocacy Conference 2011 Musa Mayer AdvancedBC.org 1 The Big Question If we want to end death from
More informationAppendix One. HER2-positive early breast cancer, its treatment and prognosis
Appendix One. HER2-positive early breast cancer, its treatment and prognosis Breast cancer and HER2/neu over-expression Health need is one of PHARMAC s nine decision criteria (http://www.pharmac.govt.nz/pdf/231205.pdf
More informationSubcutaneous Testosterone-Anastrozole Therapy in Breast Cancer Survivors. 2010 ASCO Breast Cancer Symposium Abstract 221 Rebecca L. Glaser M.D.
Subcutaneous Testosterone-Anastrozole Therapy in Breast Cancer Survivors 2010 ASCO Breast Cancer Symposium Abstract 221 Rebecca L. Glaser M.D., FACS Learning Objectives After reading and reviewing this
More informationCellular, Molecular, and Biochemical Targets in Breast Cancer
Cellular, Molecular, and Biochemical Targets in Breast Cancer Kristy Kummerow Ingrid Meszoely December 12, 2012 VUMC Resident Bonus Conference One size fits all surgical treatment of breast cancer Wilhelm
More informationReport series: General cancer information
Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for
More informationHistorical Basis for Concern
Androgens After : Are We Ready? Mohit Khera, MD, MBA Assistant Professor of Urology Division of Male Reproductive Medicine and Surgery Scott Department of Urology Baylor College of Medicine Historical
More informationA rare presentation of prostate cancer with diffuse osteolytic metastases and PSA of 7242 ng/ml
IJCRI 2011;2(9):16-20. Rajendiran et al. 16 CASE REPORT OPEN ACCESS A rare presentation of prostate cancer with diffuse osteolytic metastases and PSA of 7242 ng/ml Govarthanan Rajendiran, Linda Green,
More informationa Phase 2 prostate cancer clinical trial is ongoing. Table 2: Squalamine vs Standard-of-care literature
PRODUCT FACT SHEET Spring 2007 MISSION STATEMENT Genaera Corporation is a biopharmaceutical company with a focus on metabolic and respiratory diseases. The compounds in the Genaera pipeline address signal
More informationBreast Cancer Care & Research
Breast Cancer Care & Research Professor John FR Robertson University of Nottingham Nottingham City Hospital Breast Cancer (BC) 15,000 BC deaths in the UK each year 20% female cancer deaths 5% all female
More information7. Prostate cancer in PSA relapse
7. Prostate cancer in PSA relapse A patient with prostate cancer in PSA relapse is one who, having received a primary treatment with intent to cure, has a raised PSA (prostate-specific antigen) level defined
More informationWhat You Need to Know for Better Bone Health
What You Need to Know for Better Bone Health A quick lesson about bones: Why healthy bones matter The healthier your bones The more active you can be Bone health has a major effect on your quality of life
More informationMiquel Àngel Seguí Palmer
Miquel Àngel Seguí Palmer HER2+ Breast Cancer is characterized by overexpression of HER2 receptors HER2+ Breast Cancer is characterized by overexpression of HER2 receptors HER2+ status is associated with
More informationEffects of Bone-Targeted Agents on Cancer Progression and Mortality
DOI: 10.1093/jnci/djs263 Advance Access publication on July 2, 2012. The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
More information19. Drug Treatment Trials
1 9. D R U G T R E A T M E N T T R I A L S 19. Drug Treatment Trials The science behind the Progeria clinical drug trials Trial medications at a glance Progeria clinical drug trials The science behind
More informationINSERM/ A. Bernheim. Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance
A. Bernheim Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance OVER-MyR is funded by the European Commission within its FP7 specific
More informationKanıt: Klinik çalışmalarda ZYTIGA
mkdpk de Sonunda Gerçek İlerleme! Kanıt: Klinik çalışmalarda ZYTIGA Dr. Sevil Bavbek 5. Türk Tıbbi Onkoloji Kongresi Mart 214, Antalya Endocrine therapies Adrenals Testis Abiraterone Orteronel Androgen
More informationHormone Replacement Therapy : The New Debate. Susan T. Hingle, M.D.
Hormone Replacement Therapy : The New Debate Susan T. Hingle, M.D. Background Hormone replacement therapy (HRT) is extensively used in the United States, especially for: *treatment of menopausal symptoms
More informationEffects of Herceptin on circulating tumor cells in HER2 positive early breast cancer
Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer J.-L. Zhang, Q. Yao, J.-H. Chen,Y. Wang, H. Wang, Q. Fan, R. Ling, J. Yi and L. Wang Xijing Hospital Vascular Endocrine
More informationBreast Cancer Educational Program. June 5-6, 2015
Breast Cancer Educational Program June 5-6, 2015 Adjuvant Systemic Therapy For Early Breast Cancer: Who, What and for How Long? Debjani Grenier MD, FRCPC Medical Oncologist Disclosures Advisory Board Member:
More informationOsteoporosis Assessment Using DXA and Instant Vertebral Assessment. Working Together For A Healthier Community
Osteoporosis Assessment Using DXA and Instant Vertebral Assessment Working Together For A Healthier Community Osteoporosis The Silent Thief The Facts About Osteoporosis 1 in 2 women will develop osteoporosis
More informationGemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer
Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer Review Article [1] December 01, 2003 By George W. Sledge, Jr, MD [2] Gemcitabine (Gemzar) and paclitaxel show good activity as single
More informationBackground. t 1/2 of 3.7 4.7 days allows once-daily dosing (1.5 mg) with consistent serum concentration 2,3 No interaction with CYP3A4 inhibitors 4
Abstract No. 4501 Tivozanib versus sorafenib as initial targeted therapy for patients with advanced renal cell carcinoma: Results from a Phase III randomized, open-label, multicenter trial R. Motzer, D.
More informationMedical Therapies Limited EGM Presentation
Medical Therapies Limited EGM Presentation Maria Halasz Chief Executive Officer 5 May 2009 1 Agenda 1. Company information 2. Recent developments 3. Business strategy 4. Key value inflection points for
More informationThe Role of Bisphosphonates in Multiple Myeloma: 2007 Update Clinical Practice Guideline
The Role of Bisphosphonates in Multiple Myeloma: 2007 Update Clinical Practice Guideline Introduction ASCO convened an Update Committee to review and update the 2002 recommendations for the role of bisphosphonates
More informationBreast Cancer Treatment Guidelines
Breast Cancer Treatment Guidelines DCIS Stage 0 TisN0M0 Tamoxifen for 5 years for patients with ER positive tumors treated with: -Breast conservative therapy (lumpectomy) and radiation therapy -Excision
More informationMULTIPLE MYELOMA Review & Update for Primary Care. Dr. Joseph Mignone 21st Century Oncology
MULTIPLE MYELOMA Review & Update for Primary Care Dr. Joseph Mignone 21st Century Oncology OVERVIEW Identify the diagnostic criteria for multiple myeloma Compare first & second line therapies, using data
More informationMaintenance therapy in in Metastatic NSCLC. Dr Amit Joshi Associate Professor Dept. Of Medical Oncology Tata Memorial Centre Mumbai
Maintenance therapy in in Metastatic NSCLC Dr Amit Joshi Associate Professor Dept. Of Medical Oncology Tata Memorial Centre Mumbai Definition of Maintenance therapy The U.S. National Cancer Institute s
More information9. Discuss guidelines for follow-up post-thyroidectomy for cancer (labs/tests) HH
9. Discuss guidelines for follow-up post-thyroidectomy for cancer (labs/tests) HH Differentiated thyroid cancer expresses the TSH receptor on the cell membrane and responds to TSH stimulation by increasing
More informationTable of Contents. Data Supplement 1: Summary of ASTRO Guideline Statements. Data Supplement 2: Definition of Terms
Definitive and Adjuvant Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation
More informationMonoclonal Antibodies in Cancer. Ralph Schwall, PhD Associate Director, Translational Oncology Genentech, Inc.
Monoclonal Antibodies in Cancer Ralph Schwall, PhD Associate Director, Translational Oncology Genentech, Inc. Disclaimer I had nothing to do with Herceptin Using lessons learned in new antibody projects
More informationLocalised Cancer Treatment. PCI Biotech. Amphinex a new product for localised cancer treatment
Localised Cancer Treatment PCI Biotech Amphinex a new product for localised cancer treatment Disclaimer This document (the Presentation ) has been produced by PCI Biotech Holding ASA (the Company ). The
More informationBISPHOSPHONATE RELATED OSTEONECROSIS OF THE JAW (BRONJ) BISPHOSPHONATES AND WHAT HAPPENS TO BONE VINCENT E. DIFABIO, DDS, MS MEMBER OF THE COMMITTEE ON HEALTHCARE AND ADVOCACY FROM THE AMERICAN ASSOCIATION
More informationTreatment of Myeloma Bone Disease
Treatment of Myeloma Bone Disease James R. Berenson, MD Medical & Scientific Director Institute for Bone Cancer & Myeloma Research West Hollywood, CA Clinical Consequences of Myeloma Bone Disease Pathological
More informationOne out of every two men and one out of every three women will have some type of cancer at some point during their lifetime. 3
1. What is cancer? 2. What causes cancer?. What causes cancer? 3. Can cancer be prevented? The Facts One out of every two men and one out of every three women will have some type of cancer at some point
More informationUS Investor Presentation May 2010
US Investor Presentation May 2010 Important Notice The purpose of the presentation is to provide an update of the business of Prima Biomed Ltd ACN 009 237 889 (ASX:PRR) (Prima). These slides have been
More informationLa personalizzazione terapeutica: quanto influisce l età
La personalizzazione terapeutica: quanto influisce l età PierFranco Conte University of Padova Department of Surgery, Oncology and Gastroenterology IOV Istituto Oncologico Veneto I.R.C.C.S. Breast Cancer
More informationSMALL CELL LUNG CANCER
Protocol for Planning and Treatment The process to be followed in the management of: SMALL CELL LUNG CANCER Patient information given at each stage following agreed information pathway 1. DIAGNOSIS New
More informationBreast cancer in women diagnosis, treatment and follow-up
Breast cancer in women diagnosis, treatment and follow-up H. WILDIERS, S. STORDEUR, J. VLAYEN, R. SCHOLTEN, F. VAN DE WETERING, C. BOURGAIN, B. CARLY, MR. CHRISTIAENS, V. COCQUYT, E. LIFRANGE, JC. SCHOBBENS,
More informationAnti-CD38 anti-cd3 bispecific antibody in multiple myeloma
Anti-CD38 anti-cd3 bispecific antibody in multiple myeloma David E. Szymkowski Senior Director, Biotherapeutics Proteins by Design 1960s...1980s...2000s... Where are the bispecific antibody drugs? J Exp.
More informationCyclin CDK 4/6 inhibitors in breast cancer treatment. Agustí Barnadas Medical Oncology Department Hospital Sant Pau Barcelona
Cyclin CDK 4/6 inhibitors in breast cancer treatment Agustí Barnadas Medical Oncology Department Hospital Sant Pau Barcelona Agenda Cell-cycle pathway Cyclin CDK 4/6 inhibitors: Palbociclib Clinical efficacy
More informationHow To Take A Bone Marrow Transplant
Drug treatments to protect your bones This information is an extract from the booklet, Bone health. You may find the full booklet helpful. We can send you a copy free see page 5. Contents Bisphosphonates
More informationADJUVANT TREATMENT CLINICAL EVALUATION NEOADJUVANT TREATMENT
te: Consider Clinical Trials as treatment options for eligible patients. Referral to a center with both pediatric oncology and orthopedic surgery is essential. CLINICAL EVALUATION This practice algorithm
More informationUpdate on Clinical Trials and Foundation Funded Grants
Update on Clinical Trials and Foundation Funded Grants Mary Hesdorffer, MS, APRN-BC Medical Liaison Meso Foundation www.curemeso.org Delivering the Diagnosis Delivering the Diagnosis Day 1 Taking control
More informationAdvances In Chemotherapy For Hormone Refractory Prostate Cancer. TAX 327 study results & SWOG 99-16 study results presented at ASCO 2004
Ronald de Wit Rotterdam Cancer Institute The Netherlands Advances In Chemotherapy For Hormone Refractory Prostate Cancer TAX 327 study results & SWOG 99-16 study results presented at Slide 1 Prostate Cancer
More informationAdjuvant Therapy with Trastuzumab
Adjuvant Therapy with Trastuzumab Hiroji Iwata, M.D. Department of Breast Oncology, Aichi Cancer Center Hospital Although this presentation includes information regarding pharmaceuticals (including products
More informationMetastatic breast cancer with secondary tumours: advice for patients and relatives
Metastatic breast cancer with secondary tumours: advice for patients and relatives Metastatic breast cancer means that cancer cells from the original cancer in the breast spreads to other parts of the
More informationOsteoporosis. Dr Gordon MacDonald BSc MB BChir MRCP Consultant Rheumatologist. Rheumatology and Arthritis Seminar Tuesday 5 th February 2013
Osteoporosis Dr Gordon MacDonald BSc MB BChir MRCP Consultant Rheumatologist Rheumatology and Arthritis Seminar Tuesday 5 th February 2013 Plan What is osteoporosis? Consequences of osteoporosis Risk factors
More informationEpidemiology, Staging and Treatment of Lung Cancer. Mark A. Socinski, MD
Epidemiology, Staging and Treatment of Lung Cancer Mark A. Socinski, MD Associate Professor of Medicine Multidisciplinary Thoracic Oncology Program Lineberger Comprehensive Cancer Center University of
More informationNew Treatment Options for Breast Cancer
New Treatment Options for Breast Cancer Brandon Vakiner, PharmD., BCOP Clinical Pharmacy Specialist - Oncology The University of Iowa Hospitals and Clinics Assistant Professor (Clinical) University of
More informationReceptor conversion in distant breast cancer metastases. Breast cancer metastases: A spitting image of their primary?
Receptor conversion in distant breast cancer metastases Breast cancer metastases: A spitting image of their primary? Introduction Breast cancer is the leading cause of female cancer death worldwide (13,000
More informationTHE MANY FACES OF MCRPC: ASSESSING PATIENT PROFILES AND TAILORING TREATMENT IN A CHANGING THERAPEUTIC LANDSCAPE
THE MANY FACES OF MCRPC: ASSESSING PATIENT PROFILES AND TAILORING TREATMENT IN A CHANGING THERAPEUTIC LANDSCAPE Summary of Presentations from the Bayer Healthcare Symposium, held at the 29 th Annual EAU
More informationCorporate Medical Policy
Corporate Medical Policy Ado-Trastuzumab Emtansine (Trastuzumab-DM1) for Treatment of File Name: Origination: Last CAP Review: Next CAP Review: Last Review: ado_trastuzumab_emtansine_(trastuzumab-dm1)_for_treatment_of_her-2_positivemalignancies
More informationOI PARP ΑΝΑΣΤΟΛΕΙΣ ΣΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΜΑΣΤΟΥ ΝΙΚΟΛΑΙΔΗ ΑΔΑΜΑΝΤΙΑ ΠΑΘΟΛΟΓΟΣ-ΟΓΚΟΛΟΓΟΣ Β ΟΓΚΟΛΟΓΙΚΗ ΚΛΙΝΙΚΗ ΝΟΣ. ΜΗΤΕΡΑ
OI PARP ΑΝΑΣΤΟΛΕΙΣ ΣΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΜΑΣΤΟΥ ΝΙΚΟΛΑΙΔΗ ΑΔΑΜΑΝΤΙΑ ΠΑΘΟΛΟΓΟΣ-ΟΓΚΟΛΟΓΟΣ Β ΟΓΚΟΛΟΓΙΚΗ ΚΛΙΝΙΚΗ ΝΟΣ. ΜΗΤΕΡΑ Study Overview Inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase
More informationAdjuvant treatment of breast cancer patients with trastuzumab
doi:10.2478/v10019-007-0020-y review Adjuvant treatment of breast cancer patients with trastuzumab Erika Matos, Tanja Čufer Institute of Oncology Ljubljana, Department of Medical Oncology, Ljubljana, Slovenia
More information