Die Periphere Blutstammzell- Transplantation

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1 Die Periphere Blutstammzell- Transplantation Martin Körbling DGHO, Stuttgart, Oktober 2012

2 Der Ursprung des Begriffs Stammzelle Alexander Maximow 1909 A. Maximow, Fol. Haematol. 8;1909: St. Petersburg - Chicago

3 Der Ursprung des Begriffs Stammzelle Reviewed in Cell Stem Cell 1, 2007 Artur Pappenheim 1896 A. Pappenheim, Virchows Arch. 145;1896: Berlin Charité 1905

4

5

6 Shielding Experiments Science 113; 1951 cells migrate out from the shielded tissue and are responsible for the enhancement of recovery

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8 Parabiosis Experiments Proc Soc Exp Biol Med 77; 1951 This accelerated regeneration of hemopoiesis may be due to transplantation of blood-forming cells from non-irradiated partner

9 Eugene P. Cronkite Brookhaven National Laboratory, Upton, NY

10 First Publication Suggesting the Existence of Circulating Stem Cells Science 128; 1958 circulating multipotential cells would explain the findings of DNA synthesizing cells...

11 Experimental White Blood Cell Transfusions Into Lethally Irradiated Mice Oak Ridge National Laboratory, Tennessee Blood 19; 1962

12 E. Donnall Thomas 1920 born in Texas Harvard Medical School and M.I.T Mary Imogene Basset Hospital, Cooperstown, N.Y. (Columbia University) 1963 University of Washington, Seattle 1990 Nobel Prize, Medicine

13 Experimental White Blood Cell Transfusions Into Lethally Irradiated Dogs Cooperstown, N.Y. Blood 23; 1964 University of Washington, Seattle, WA Blood 30, 1967

14 Emil J Freireich NCI-IBM Blood Cell Separator Univ. of Texas MD Anderson Cancer Center Houston, 1968

15 First Clinical Stem Cell Collections by Continuous-Flow Apheresis Science 171; 1971 Kenneth McCredie University of Texas M.D. Anderson Cancer Center

16 Theodor M. Fliedner Brachte das Konzept der klinischen Blutstammzell-Transplantation nach Deutschland 1967 Professur für Klinische Physiologie am Zentrum für Klinische Grundlagenforschung der Universität Ulm Rektor der Universität Ulm

17 Experimental Stem Cell Apheresis and Transplantation in a Canine Model NCI-IBM Blood Cell Separator, Ulm University,

18

19 GVH-D in a Canine DLA-Matched Peripheral Blood Stem Cell Transplantation Setting Ulm University 1978

20 The Research Team at Ulm University 1978 T.M. Fliedner W. Calvo M.Korbling W.Nothdurft W.Ross

21 Procurement of Human Blood Stem Cells by Continuous-Flow Centrifugation Blood 50; 1977 AMINCO (American Instrument Company) Blood Cell Separator Ulm University, Germany, 1979

22 Failed Clinical Peripheral Blood Stem Cell Transplant Attempts Nature 256; 1975 Edinburgh, UK The Lancet; 1979 Univ. of California at Los Angeles circulating colony-forming cells are victims of clonal senescence, and have been expelled as waste products from the bone marrow. Blood 56; 1980 NIH, Bethesda, MD

23 George W. Santos M.I.T. and Johns Hopkins Medical School Director, Bone Marrow Transplant Program, Johns Hopkins Oncology Center, Baltimore, MD 1987 Einführungsvortrag anlässlich der 50. Jahrestagung der DGHO in Würzburg Doktor honoris causa Universität München

24 First Attempted Autologous Peripheral Blood Stem Cell Transplantation Total CFU-GM contained in blood stem cell autograft: 0.02 x 10 6 /kg body weight Experimental Hematology 9, 1981 Johns Hopkins Oncology Center, Baltimore, MD

25 Heidelberg University

26 First Autologous Peripheral Blood Stem Cell Transplantation Total CFU-GM contained in blood stem cell autograft: 0.26 x 10 6 /kg body weight Presented at International Autologous Bone Marrow Transplant Meeting, Parma, Italy, July 8-11, 1985 Blood 67; times cited (Thomson Reuters)

27 Autologous Peripheral Blood Stem Cell Transplantations in 1986/87 Exp. Hematology 14; 1986 Omaha, Nebraska Exp. Hematology 14; 1986 Bordeaux, France Bone Marrow Transplantation 2; 1987 Adelaide, Australia

28 G-CSF for Stem Cell Mobilization Proceedings of the National Academy of Sciences USA 82; 1985 Sloan-Kettering Cancer Center, N.Y. Blood 72; 1988 Melbourne, Australia

29 Concern About Using G-CSF in Healthy Stem Cell Donors Risk of triggering lympho-hematopoietic malignancies in genetically pre-disposed healthy sibling donors

30 G-CSF Mobilization of Blood Stem Cells in Healthy Donors Bone Marrow Transplantation 11; 1993 Sapporo, Japan In 1999 the US National Marrow Donor Program (NMDP) approved protocol for primary G-CSF mobilized stem cell collection in unrelated donors Bone Marrow Transplantation 27; 2001

31 Concern About Allogeneic Peripheral Blood Stem Cell Transplantation Risk of inducing severe acute graft-versus-host disease T-cells contained in PBSC allografts 10 times higher than in BM allografts

32 First Attempted Allogeneic Peripheral Blood Stem Cell Transplantations Bone Marrow Transplantation 4; 1989 Omaha, Nebraska Follow up: 32 days The Lancet 341; 1993 Nottingham, UK Follow up: 58 days

33 First Series of Successful Allogeneic Peripheral Blood Stem Cell Transplantations MD Anderson Cancer Center, Houston, Texas Blood 85; 1995 Fred Hutchinson Cancer Research Center, Seattle, WA Blood 85; 1995 Kiel University Hospital, Germany Blood 85; 1995

34 Allogeneic PBSCT versus Allogeneic BMT Fred Hutchinson Cancer Research Center, Seattle, WA City of Hope Medical Center, Duarte, CA Stanford University, Stanford, CA New Engl. J. Med. 344; 2001 Blood 95; 2000

35 100 Autologous Stem Cell Sources by Recipient Age Bone Marrow (BM) Peripheral Blood (PB) BM + PB 80 Transplants, % Age 20 yrs Age > 20 yrs Slide 5 SUM-WW11_4.ppt

36 Allogeneic Stem Cell Sources by Recipient Age Bone Marrow (BM) Peripheral Blood (PB) Cord Blood (CB) Transplants, % Age 20 yrs Age > 20 yrs Slide 4 SUM-WW11_3.ppt

37 Unrelated Donor Stem Cell Sources by Recipient Age Bone Marrow (BM) Peripheral Blood (PB) Cord Blood (CB) Transplants, % Age 20 yrs Age > 20 yrs Slide 12 SUM-WW11_12.ppt

38 Circulating Stem Cells Hematopoietic stem cells Hematopoietic reconstitution Endothelial progenitor cells Neovascularisation Mesenchymal stem cells Tissue repair induced pluripotent stem cells from blood mononuclear cells (ipscs) Tissue repair Tumor stem cells Tumor stem cell depletion

39 Die Blutstammzelle W. Calvo, 1978

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