Key Findings. Use this report to... The Autoimmune Market Outlook to 2013

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1 Key Findings The global autoimmune market generated sales of $31.9bn in, an increase of 14.4% over 2006 sales. The market is forecast to grow at a CAGR of 8.1% to reach a total value of $51.0bn in Immunosuppressant drugs dominate the automimnune market, with four products from this class accounting for 40.3% of total market sales. The highest selling immunosuppressant drug was J&J/Schering-Plough s Remicade, with 42.1% of total sales in this class. Pfizer s Celebrex dominated the COX-II market with a share of 81.3% in. Celebrex maintained blockbuster status despite the earlier withdrawals of major blockbuster COX-II inhibitors such as Vioxx and Bextra. Figure 5.6: Competitive dynamics of leading players in the autoimmune market, Roche ($1.7bn) and Astellas ($1.6bn), two of the leading companies in the global autoimmune market, also registered a strong year-on-year sales growth of 13.2% and 19.3% in, driven mainly by the strong sales growth of CellCept and Prograf, respectively... Roche s Actemra is expected to be launched in the US during Q1 2010, in view of the FDA s request for additional data and Roche s risk mitigation strategy. Actemra is forecast to generate sales of $680m in Amgen is the global autoimmune market leader, having accrued a market share of 11.2% ($3.6bn) in. This was driven almost entirely by Enbrel ($3.5bn) which had a sales increase of 12.2%. Novartis' developmental MS drug fingolimod (FTY-720) is one of the strongest competitors to Biogen Idec's MS franchise due to its potency and convenience of once daily oral dosing. Use this report to... Assess patient potential, treatment trends and sales patterns of major autoimmune indications over the period , with this report s coverage of osteoarthritis, rheumatoid arthritis, crohn s disease, systemic lupus erythematosus, ulcerative colitis and multiple sclerosis markets across Japan, France, Germany, Italy, Spain, the UK and the US. Discover the market dynamics of the autoimmune area and understand the impact of recent events by assessing key market trends, growth drivers and the latest issues affecting product development. Compare the market performance and strategic positioning of major pharma companies autoimmune portfolios with this report s evaluation of the franchises and market shares of Amgen, Abbott, J&J, Pfizer, Novartis, Wyeth, Roche and Astellas. Evaluate the autoimmune pipeline compounds of leading companies with this report s detailed analysis of clinically differentiated pipeline products by indication, and sales forecasts for key R&D pipeline products to 2013.

2 Explore issues including... Reduced commercial opportunity for Coxibs. The commercial opportunity for the COX-II inhibitor class has been substantially reduced due to cardiovascular safety concerns. The US withdrawals of Vioxx and Bextra, in addition to the non-approvals of Arcoxia and Prexige, are likely to restrict the growth prospects of this class in the near future. Impact of high value biologic treatments. Orencia, for use in DMARD failures, has yet to significantly affect the growth of existing agents. BMS s Orencia and Roche s Actemra target rheumatoid arthritis patients refractory to anti-tnfs, a population estimated to be between 20-40% of moderate/severe RA patients. Figure 3.27: Leading coxib brands in the global autoimmune Sales of the leading COX-2 inhibitors accounted for 99.1% of the global COX-2 market in, with a modest growth of 14.0% in sales over Sales of Pfizer s Celebrex ($2.3bn) dominated the COX-2 market, Cost of MS treatments. Research has shown that with an 81.3% share in... the cost of being diagnosed with MS in the UK is nearly 17,000 per person. The research also found that among 2,000 people surveyed from across the UK, half stated that they had to leave work due to MS, which increased the potential cost to over 25,000 per person when lost employment productivity is added. Importance of arthritis disease. Although several novel artrhitis treatments have been launched in recent years, it is possible for many patients to acheive effective disease control from the better use of existing medications. Discover... What will be the major growth indications in the autoimmune market over? Which products will be affected by generic competitors over the period? Which companies were the winners and losers in this market in? Which pipeline products will be the growth drivers of the future? How have major launches from companies such as Amgen, Roche, Abbott and J&J performed? Which indications have the highest levels of market potential over the period? Which companies will become key players in the autoimmune market over? What will be the competitive landscape in osteoarthritis, rheumatoid arthritis, crohn s disease, lupus, ulcerative colitis and multiple sclerosis in 2013?

3 Sample Information Chapter 5: Competitive landscape Sales focus by drug class Novartis markets a broad range of products across a range of therapy areas and has very comprehensive coverage of drug classes when compared to other pharmaceutical companies featured in this report. The majority of Novartis sales are derived from products falling under the immunosuppressant class of drugs with the key drug being Sandimmun (cyclosporine), which was responsible for $831m sales in. Voltaren, an NSAID accrued $1.1bn in, making it the company s top selling drug in. Voltaren is marketed Figure 5.11: Novartis autoimmune sales by in different formulations ranging from oral to topical, and thus sales accrued by Voltaren contribute towards products falling under the plain NSAIDs as well as topical anti-rheumatic agents. Business Insights Marketed product portfolio Novartis autoimmune franchise registered a growth rate of 11.7% in , representing sales of $2.6bn in. Voltaren, the company s top selling product has witnessed a strong y-o-y sales growth of 9.7% or $1.1bn in. Marketed as an oral tablet as well as a topical formulation, the oral formulation of Voltaren had witnessed a stronger sales performance in 2006, accounting for 58.2% Table 5.57: Novartis autoimmune product of total product sales. Major growth drivers Novartis autoimmune portfolio include Myfortic, which registered a strong y-o-y sales growth of 63.3%, garnering sales of $149m in. Myfortic is indicated for the reduction of organ rejection during renal transplants. The drug has strong clinical efficacy and tolerability profiles, translating into strong market performance since its launch in Business Insights Certican, a novel proliferation signal inhibitor with immunosuppressive and anti-proliferative properties is indicated for the treatment of organ rejection in transplantation, garnered sales of $50m in, representing y-o-y sales growth of 85.5%. Prexige, a COX-2 inhibitor, registered the strongest growth rate of 120.6% among all products featured in Novartis autoimmune franchise during the period. (Continued...) -181-

4 Table of Contents CHAPTER 1: SCOPE AND METHODOLOGY Scope Methodology CHAPTER 2: EPIDEMIOLOGY OF AUTOIMMUNE DISEASES Osteoarthritis Rheumatoid arthritis Crohn s disease Systemic lupus erythematosus Ulcerative colitis Multiple sclerosis CHAPTER 3: GLOBAL MARKET ANALYSIS Summary Market analysis by country Trends in generics usage and licensing Market analysis by drug class Leading brands dynamics Key events in the autoimmune market - Enbrel growth slowing as it faces stiff competition from Humira - RoActemra receives positive opinion in Europe for the treatment of RA - NICE admits previous guidance around sequential use of anti-tnf therapies in RA is unfair - Study shows prohibitive cost of MS treatment - Mayo Clinic collaborates to advance Crohn's treatment - Arthritis research shows better disease is more important than the use of drugs - CellCept s off-label use in lupus continues to increase Immunosuppressants immunosuppressants - Leading brands of immunosuppressants - Clinical developments - Immunosuppressants sales forecasts to 2013 Specific anti-rheumatic agents specific anti-rheumatic agents - Leading brands of specific antirheumatic agents - Specific anti-rheumatic agents sales forecasts to 2013 Non-steroidal plain nonsteroidal plain - Leading brands of nonsteroidal plain - Non-steroidal plain antirheumatics sales forecasts to 2013 Topical topical - Leading brands of topical - Topical anti-rheumatic sales forecasts to 2013 Coxibs coxibs - Leading brands of coxibs - Coxibs sales forecasts to 2013 Non-steroidal (combinational) non- steroidal (combinational) - Leading brands of non-steroidal (combinational) - Non-steroidal (combinational) sales forecasts to 2013 Anti-rheumatic corticosteroids antirheumatic corticosteroids - Leading brands of anti-rheumatic corticosteroids - Anti-rheumatic corticosteroids sales forecasts to 2013 Total autoimmune sales forecasts to 2013 CHAPTER 4: PIPELINE ANALYSIS Key trends in R&D - Biologics - Combination drugs - Aggressive medical therapy becoming the standard of care - TNF inhibitors has a strong presence in autoimmune market - Efforts to develop fully human monoclonal antibodies

5 Table of Contents The autoimmune pipeline Leading drugs in development Profiles of key pipeline products - Phase III compounds - Licofelone (ML3000) Merckle GmbH - Ocrelizumab (R-1594) Genentech, Biogen IDEC, Chugai and Roche - LymphoStat-B (belimumab) Human Genome Sciences (HGS) and GSK - Ofatumumab (HuMax-CD20) Genmab and GSK - Fingolimod (FTY-720) Novartis/Mitsubishi Tanabe Pharma - Fampridine-SR Acorda - Campath (alemtuzumab) Genzyme and Bayer Schering Pharma - Recently approved/marketed drugs - Cimzia (certolizumab pegol) UCB - Golimumab (CNTO-148) Centocor/Schering-Plough - Actemra (tocilizumab) Roche/Chugai - Tysabri (natalizumab) Elan/Biogen Idec - Mesavance (mesalamine) Shire Pipeline forecasts - Factors affecting forecasts - Autoimmune pipeline forecast CHAPTER 5: COMPETITIVE LANDSCAPE - Sales performance of leading players Detailed analysis of leading autoimmune players Amgen Abbott Johnson and Johnson Pfizer Novartis Wyeth - Wyeth and Pfizer Roche Astellas LIST OF FIGURES Worldwide autoimmune market share by geography, Sales of types of autoimmune brands, Prevailing treatment approach for arthritis (OA and RA) The autoimmune pipeline by indication and stage of development, Leading recently launched products and late-stage R&D in the autoimmune disorders market, 2008 Competitive dynamics of the leading players in the global autoimmune market, Amgen s autoimmune sales by Abbott s autoimmune sales by J&J s autoimmune sales by drug class, Pfizer s autoimmune sales by Novartis autoimmune sales by Wyeth s autoimmune sales by Roche s autoimmune sales by Astellas autoimmune sales by LIST OF TABLES Estimated prevalence of autoimmune diseases across seven major markets, Estimated prevalence of OA

6 Table of Contents Forecast epidemiology of OA Estimated prevalence of RA Forecast epidemiology of RA Estimated prevalence of CD Forecast epidemiology of CD Estimated prevalence of lupus Forecast epidemiology of lupus Estimated prevalence of UC Forecast epidemiology of UC Estimated prevalence of MS Forecast epidemiology of MS Worldwide autoimmune sales by countries, Breakdown of the global autoimmune market by drug class, Leading brands in the global autoimmune market, Leading immunosuppressant Remicade launch status in major markets Immunosuppressants sales forecast, Leading specific anti-rheumatic Enbrel launch status in major markets Specific anti-rheumatic agents sales forecast, Leading non-steroidal plain antirheumatic brands in the global autoimmune Non-steroidal plain antirheumatics sales forecast, Leading topical anti-rheumatic Topical anti-rheumatic sales forecast, Leading coxib brands in the global autoimmune market, Coxibs sales forecast, Leading non-steroidal (combinational) anti-rheumatic Non-steroidal (combinational) sales forecast, Leading anti-rheumatic corticosteroid brands in the global autoimmune market, Anti-rheumatic corticosteroids sales forecast, Therapeutic sales forecasts by drug class, An overview of Licofelone An overview of Ocrelizumab An overview of LymphoStat-B An overview of Ofatumumab An overview of FTY-720 An overview of Fampridine-SR Fampridine-SR Phase III data An overview of Campath An overview of Cimzia An overview of Golimumab An overview of Actemra An overview of Tysabri An overview of Mesavance Autoimmune pipeline sales forecasts, Leading players in the global autoimmune market, ($m) Amgen s autoimmune product Amgen s autoimmune R&D Abbott s autoimmune product Abbott s autoimmune R&D J&J s autoimmune product J&J s autoimmune R&D product pipeline, 2008 Pfizer s autoimmune product Pfizer s autoimmune R&D product pipeline, 2008 Novartis autoimmune product Novartis autoimmune R&D Wyeth s autoimmune product Wyeth s autoimmune R&D Roche s autoimmune product Roche s autoimmune R&D Astellas s autoimmune product Astellas s autoimmune R&D

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