data sheet DONATELLO Rev. I emiss - 25/10/ PRO03 code Automatic tissue processor DONATELLO

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1 Rev. I emiss - /0/0 DONATELLO Automatic floor closed cycle processor for histological specimens Automatic tissue processor DONATELLO code PRO0 General characteristics DONATELLO is a closed cycle processor for histological specimens dedicated to those Pathologits requiring quick and reliable results. Conceived with advanced technologies and with unique features, it assures the maximum operator safety and a new specimen standardization level. DONATELLO processes tissues, both with standard protocols and with non-toxic substitute products such as Ottix Plus and Ottix Shaper. For both the processor has optimized and studied protocols. With a processor capacity of 0 specimens, paraffin melting basins and easy-to-use software, it is on the top of its category.

2 Rev. I emiss - /0/0 Functions: Histological specimens processing, with vacuum/pressure, controlled paraffin/reagent heating functions Processing with non-toxic reagents (Ottix and Ottix Shaper) or with standard procedures (xylol and alcohol) Processing with delayed starting up possibility and end processing time setting Software guided reagent loading and unloading operations Reagent management and quality control system RMS (Reagent Management System) Possibility to have different loading: 0, 0, 0 cassettes with controlled reagent quantity use according to the loading Automatic system for paraffin cleaning and purification WCC (Wax Cleaning Cycle) PWD (Protected Wax Dumping) function for the automatic or manual unloading of the exhausted paraffin directly in a tank EWD (External Wax Dumping) function for the automatic or manual unloading of the exhausted paraffin through an insulated pipe Actived charcoal filter against harmful fumes loss in the environment with exhaustion control Colour touch screen, resistant to solvents Graphical representation of the processing, through an intuitive software Up to programmable processing protocols Quick start-up of the most used protocols Reverse cycle and washing programs Visual processing graph with temperature and vacuum/pressure for each processing step Possibility to data mining through an external USB key or through an external printer with usb connection Different kind of agitations Remote alarm (optional) Capacity and productivity: 0 standard cassettes capacity ( baskets made of stainless steel with capacity of 0 organized cassettes each) paraffin melting basins of lt each reagent tanks: - 0 reagent tanks with. lt filling volume, one of them has a double function: reagent containment or liquid paraffin unloading collecting - reagent tanks with washing reagents with. lt filling volume Installation: Floor model, minimum capacity 00 Kg/mq, leveled base with adjustable feet Remote assistance (optional): Real-time technical assistance for the control software in remote modality (*) (*) The customer shall have the DSL line and the access account management to the computer network

3 Rev. I emiss - /0/0 CHARACTERISTICS OF USE Processing protocols setting () Modern processor controlled by a software that allows to manage all the standard and advanced functions for the routine processings. Processing protocols saved in the control PC. Starting up of the processing selectioning the protocol and pushing the start key on the touch screen. Storage of all necessary protocols, with possibility to set: used reagents, processing time, temperature, vacuum and pressure option, reagent agitation. () Possibility to save up to different protocols. Special program for the reversed processing and washing programs. Protocol starting up with end processing date and time setting. Processing chamber () Processing chamber made of stainless steel, with baskets, capacity of 0 standard cassettes. sensors to set-up processing loading and insert in the chamber the right quantity of reagent necessary for the processing. Control function for the right processing chamber loading, like the presence of one basket at least. Processing speeding up through vacuum and pressure, agitation and reagents temperature setting. () ()

4 Rev. I emiss - /0/0 RMS (Reagent Management System) () Reagent management and quality control system. Advanced software function for reagent exhaustion control. Through a deterministic process, calculation of processing potentiality progressive reduction of each reagent. RMS system controls and signals reagent consumption. Graphical indication of reagent replacement need, when exhausted, avoiding any other processing with non-suitable reagents. () The possible processings number, for each reagent, is defined in accordance to the processed tissue typology and used protocols. For each reagent, a cassettes limit number is set. Tanks with special functions () Some DONATELLO tanks are dedicated to special functions. For a better ease to use, it is possible to unload the paraffin directly into the tank on position (). This option, called PWD (Protected Wax Dumping), avoids the pouring through external pipes and avoids the risk to pour out the liquid paraffin during unloading operations. DONATELLO has two dedicated tanks for reagents, useful to clean the chamber and the pipes. Using nontoxic reagents, the tank () will contain Ottix Plus while the tank () Ottix Shaper. The control software performs washing cycles to preserve the processor efficiency. () Attention: in the image reported the tanks have different colours only to make easy reagent tank position reading.

5 Rev. I emiss - /0/0 Automatic tissue processor DONATELLO Control monitor PC with LCD colour, touch screen " panel Grain paraffin melting chambers, capacity lt each USB port for software upgrade and data saving: reagent record, diagnostics log Transparent door, closure and protection for reagent tanks compartment Reagent tanks,. lt capacity Wheels for transport Quick draft connectors for loading/unloading reagent system Processing chamber opening handle Processing chamber made of stainless steel AISI, loading capacity up to 0 standard cassettes, filling levels

6 Rev. I emiss - /0/0 Reagent tanks position: 0 Standar processing OTTIX processing Formalin Water Formalin Water Alcohol 0 Ottix Shaper 0 Alcohol Alcohol Alcohol Alcohol Alcohol Xylol Xylol Xylol (washing) Alcohol (washing) 0 Ottix Plus Ottix Plus Ottix Plus Ottix Plus Empty tank Empty tank Empty tank Ottix Plus (washing) Ottix Shaper (washing) Paraffin - /- Paraffin - /- Paraffin - /- Attention: in the image reported the tanks have different colours only to make easy reagent tank position reading. Paraffin - /- Paraffin - /- Paraffin - /-

7 Rev. I emiss - /0/0 Available accessories: Code Description 0 Basket for 0 cassettes (sorted) 00 Chacoral filter ( pc) 0 Printer, 0 columns (-0 V) 0 Auto-Dialer (-0 V) 0 Basket bulk for cassette (unsorted) or for oversized surgical specimens Dimensions and weight: Dimensions: Bulk for the installation: Dry-weight: 0Wx00Dx0H mm 000Wx00Dx00H mm Kg Available model: code PRO0 code PRO0 Automatic tissue processor DONATELLO Automatic rapid tissue processor DONATELLO FAST

8 Rev. I emis - /0/0 Technical characteristics: Instrument: Specimen typology: Cassettes processing capacity: Total SPC volume: Equipped baskets: SPC sensors in the processing chamber: Storable protocols number: Max time for each step: Max delay time: Process end time: Process start: Reagent tanks: Paraffin melting basins: Melting time (approximate): Paraffin bath cycle: Reagent heating temperature: Paraffin heating temperature: Process pressures: Reagent agitation: Vacuum and presure function: Reagent management system: Hardware & Software features: Reagent vapours treatment: Power supply: Automatic closed cycle floor processor Histological tissues 0 standard cassettes, lt baskets made of stainless steel with capacity of 0 cassettes each optical sensors for the detection of the right filling processing programs: favorite programs, with quick starting up washing programs program for the inversed processing hours and minutes days, hours, minutes Modifiable for each process, self-recording Programmable by the user, which: 0 reagent tanks, capacity. lt (*) reagent tanks for washing reagents, capacity. lt basins of Lt each hours Activated by the user room temperature - C - C 00/00 Hpa Sortable, with frequency from min to 0 min (V/P, V, P, environment) RMS: complete control on reagents, paraffins, clean cycles and charcoal filters Monitor with touch sensible panel, color LCD-TFT touch screen " USB.0 port (available n. ) for data transfer, backup, printer and UPS connection LAN net port 0/00Mb (Ethernet) Windows XP Embedded operative system Input for external alarm ( v AC/DC max A) Specific charcoal filter, with forced ventilation 00-0 Vac 0-0Hz (*) Optionally it is possible to use of the 0 tanks for paraffin internal automatic unloading