Access to hormone receptor testing and other basic diagnostic pathology services in Colombia

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Access to hormone receptor testing and other basic diagnostic pathology services in Colombia"

Transcription

1 Access to hormone receptor testing and other basic diagnostic pathology services in Colombia Dr Fernando Perry Clínica de seno y tejidos blandos Instituto Nacional de Cancerología de Colombia

2 Breast cancer incidence Women (All ages) - ASR per

3 Cancer incidence and mortality in Colombia Women (All ages) ASR per 100,000 Breast Cervix Thyroid Stomach Colon and rectum Lung Ovary etc. Non-Hodgkin lymphoma Leukemia New cases yearly Breast: 7,007 Incidence Mortality Melanoma Pardo C et al. Cancer incidence and mortality in Colombia INC; 2010

4 New cancer cases at the I.N.C.; 2008 Skin Uterine cervix Breast Stomach In situ breast cancer : 4.7% Anuario Estadístico INC 2008

5 ASCO: A basic pathology report Review of 13 markers and their clinical usefulness The evaluation of estrogen, progesterone, and Her2 receptors is supported by scientific evidence American Society of Clinical Oncology 2007 Update of recommendations for the Use of Tumor Markers in Breast Cancer VOLUME 25 NUMBER 33 NOVEMBER

6 Receptor ASCO St. Gallen NCCN Estrogen receptors Progesterone receptors HER2/neu receptors Yes Yes Yes Yes Yes Yes Yes Yes Yes Hernan Vargas. The Breast Journal, Volume 9, Suppl. 2, 2003 S81 S85

7 A basic pathology report for a primary tumor in Colombia Hematoxilyn and eosin stain Cancer diagnostic: in situ - Invasive Histology of cancer in situ? Tumor grade: cellular - nuclear Lymphovascular invasion Intraductal component Histological type?

8 A basic pathology report for axillary lymph nodes in Colombia Sentinel lymph node Hematoxilyn and eosin: metastases Extent of metastatic disease: micrometastases, partial, total, extracapsular extension Number of lymph nodes Axillary dissection Similar exception made of micrometastases.

9 Hormone receptors: review Receptor Review (1) Double reading (5997 specimens) Positive estrogen receptor (ER+) Positive progesterone receptor (PR+) 75 % 55 % ER + / PR % 55 % ER +/ PR % 20 % ER - / PR % 0 % ER - / PR % 25 % Lancet 2005 ; 365 :

10 Current status of hormone receptors evaluation in Colombia Clínica San Pedro Claver (Bogota) : hormone therapy 40 % in 240 cases. González. Revista Salud Publica 8(2) Hospital San Ignacio (Bogota): 207 patients, estrogen receptors 59.9 %, progesterone receptors 55.2 %, Her2/neu 5.2 %. Angarita. Rev Colom Cir 2010; 25 : INC (Bogota): Positive estrogen receptors 65 %, progesterone 56.5 %, non assesed 10 %. Piñeros M & Perry F. Rev Colom Cancerol 2008;12(4): Clínica del Country (Bogota): Positive hormone receptors 60.4 %, negative receptors 16.5 %, unknown 23.1 %

11 Benefits Hormone receptors: Hormone blocking therapy, adjuvant tamoxifen Decrease in mortality by 31% and relapse decreased by 41%. Aromatase inhibitors: No significant difference in mortality reduction against tamoxifen Her 2 / neu : Adjuvant trastuzumab Relapse decrease by 37% and mortlaity reduction by 34% (3 years).

12 Hormone receptors accessibility in Colombia

13 Amplification of the Oncogen HER2 by Immunohistoquemistry and FISH in Patients with Breast Cancer in Colombia. Analysis of 2879 Consecutive Cases Comparing Results between Peripheral Laboratories and a Single Reference Institution False negative rate 24.4 % False positive rate 14.8 % A high number of inadequate block tissues send for FISH. Andrade RE, Plata A, López R. Departamento de Patología y Laboratorio Clínico. Abstract: 99th annual Meeting United States And Canadian Academy of pathology Maarriot hotal Washintongton. DC Marzo Hospital Universitario Fundación Santa Fe de Bogota. Bogota, Colombia.

14 Breast cancer mortality and breast cancer centers in Colombia Oncology-pathology services Oncology pathologists Breast surgeons

15 Base case input data Cost of Tamoxifen ($US annual) Cost Trastuzumab ($US annual) 54,931.3 Cost of immunohistochemical test hormonal receptor ($US) 24.9 Cost of immunohistochemical test HER2neu ($US) 75.6 Cost Fish test ($US) Cost of relapse treatment in hormone positive receptor patients (1) 15,108.6 Cost of relapse tratment in HER2-Neu positive patients (2) 75,865.9 Relapse risk among patients receiving tamoxifen (%) (3) 33.2 Relapse risk without tamoxifen (%) (3) 45.0 Relapse risk among patients receiving trastuzumab (%) (4) 8.2 Relapse risk without trastuzumab (%) (4) 15.3 Risk of death among patients receiving trastuzumab (%) (4) 6.0 Risk of death withour trastuzumab (%) (4) Instituto Nacional de Cancerología. Estrategia óptima de manejo con hormonoterapia adyuvante en pacientes con cáncer de mama receptor hormonal positivo para Colombia Bogotá: INC, In press 2. Sanchez O. Estudio de costo efectividad del uso de trastuzumab como tratamiento adyuvante del cáncer de mama temprano her2 positivo en el Instituto Nacional de Cancerologia, desde el punto de vista del pagador. Tesis de grado programa Maestría en Epidemiología Clínica Universidad Nacional de Colombia. 3. Clarke M, Collins R, Darby S et al. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet. 2005; 365: Viani GA, Alfonso SL, Stefano EJ, De Fendi LI, Soares FV. Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer. 2007;8(7):153

16 Incremental and averted costs for breast cancer treatment in Colombia Tamoxifen Trastuzumab Cost in thousand ($US) Incremental costs Averted costs Cost in thousand ($US) Incremental costs Averted costs

17 Incremental Cost-Effectiveness Ratio Trastuzumab Per capita GDP (2007): US 4,891 Relapse Death ICER (Thousand US$/averted events) Case HER2neu positive Relapse (%) 1 Overall mortality 1 (%) Relapse (No. cases) Deaths (No. events) Trastuzumab 1, No trastuzumab 1, Cases averted

18 Our proposal To standardize sample processing regarding quality of tissue section, paraffin, and buffered formalin. Reading and interpretation by a specialized pathologist. Progesterone receptors? To reduce cost of Her2/neu diagnosis: tariff control,.

19 GRACIAS

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain

Changes in Breast Cancer Reports After Second Opinion. Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Changes in Breast Cancer Reports After Second Opinion Dr. Vicente Marco Department of Pathology Hospital Quiron Barcelona. Spain Second Opinion in Breast Pathology Usually requested when a patient is referred

More information

Adjuvant Therapy for Breast Cancer: Questions and Answers

Adjuvant Therapy for Breast Cancer: Questions and Answers CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Adjuvant Therapy for Breast

More information

Prognostic and Predictive Factors in Breast Cancer Kyle T. Bradley, MD, MS CAP Cancer Committee

Prognostic and Predictive Factors in Breast Cancer Kyle T. Bradley, MD, MS CAP Cancer Committee Prognostic and Predictive Factors in Breast Cancer Kyle T. Bradley, MD, MS CAP Cancer Committee Breast cancer is the most common malignant tumor in American women and is second only to lung cancer as a

More information

Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs. Case Study. Surgery. Lumpectomy and Radiation

Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs. Case Study. Surgery. Lumpectomy and Radiation Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs Michael Alvarado, MD Associate Professor of Surgery University of California San Francisco Case Study 59 yo woman with new palpable

More information

Targeted therapies for Early Stage Breast Cancer. Cynthia Vakhariya D.O. Providence Hospital

Targeted therapies for Early Stage Breast Cancer. Cynthia Vakhariya D.O. Providence Hospital Targeted therapies for Early Stage Breast Cancer Cynthia Vakhariya D.O. Providence Hospital Case 55-year-old postmenopausal woman Routine screening mammogram 3 cm irreg mass in L breast Left breast ultrasound

More information

Description of Procedure or Service. assays_of_genetic_expression_to_determine_prognosis_of_breast_cancer 11/2004 3/2015 3/2016 3/2015

Description of Procedure or Service. assays_of_genetic_expression_to_determine_prognosis_of_breast_cancer 11/2004 3/2015 3/2016 3/2015 Corporate Medical Policy Assays of Genetic Expression to Determine Prognosis of Breast File Name: Origination: Last CAP Review: Next CAP Review: Last Review: assays_of_genetic_expression_to_determine_prognosis_of_breast_cancer

More information

Proportion of patients with invasive breast cancer in whom ER, PR and/or

Proportion of patients with invasive breast cancer in whom ER, PR and/or 1.1.a. Proportion of patients with invasive breast cancer in whom ER, PR and/or HER2 status assessment were performed 1.1.b. Proportion of patients with invasive breast cancer in whom systemic treatment

More information

Breast Cancer Treatment Guidelines

Breast Cancer Treatment Guidelines Breast Cancer Treatment Guidelines DCIS Stage 0 TisN0M0 Tamoxifen for 5 years for patients with ER positive tumors treated with: -Breast conservative therapy (lumpectomy) and radiation therapy -Excision

More information

Breakthrough Treatment Options for Breast Cancer

Breakthrough Treatment Options for Breast Cancer Breakthrough Treatment Options for Breast Cancer Guest Expert: Lyndsay, MD Associate Professor of Medical Oncology, Yale Cancer Center www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center

More information

2012 CANCER PROGRAM ANNUAL REPORT

2012 CANCER PROGRAM ANNUAL REPORT MERCY REGIONAL CANCER CENTER 2012 CANCER PROGRAM ANNUAL REPORT Using 2011 Data Mercy Regional Cancer Center When you have cancer, you might think first of treatments chemotherapy and radiation. You want

More information

Breast Cancer Educational Program. June 5-6, 2015

Breast Cancer Educational Program. June 5-6, 2015 Breast Cancer Educational Program June 5-6, 2015 Adjuvant Systemic Therapy For Early Breast Cancer: Who, What and for How Long? Debjani Grenier MD, FRCPC Medical Oncologist Disclosures Advisory Board Member:

More information

GUIDELINES ADJUVANT SYSTEMIC BREAST CANCER

GUIDELINES ADJUVANT SYSTEMIC BREAST CANCER GUIDELINES ADJUVANT SYSTEMIC BREAST CANCER Author: Dr Susan O Reilly On behalf of the Breast CNG Written: December 2008 Agreed at CNG: June 2009 & June 2010 Review due: June 2011 Guidelines Adjuvant Systemic

More information

Based on SIOG recommendations: Lancet Oncol 2007 (8) p 1101

Based on SIOG recommendations: Lancet Oncol 2007 (8) p 1101 Breast cancer in the older pts H. Wildiers University Hospitals Leuven Belgium Based on SIOG recommendations: Lancet Oncol 2007 (8) p 1101 Introduction INCIDENCE: >40% occurs > 65y of age TUMOR BIOLOGY:

More information

Abstract Introduction. Aim of the study. Conclusion. Patients and methods. Keywords. Results. R. Abo El Hassan 1, M. Moneer 2

Abstract Introduction. Aim of the study. Conclusion. Patients and methods. Keywords. Results. R. Abo El Hassan 1, M. Moneer 2 Original Study Outcome of HER2 positive luminal operable breast cancer in comparison with outcome of other operable luminal breast cancer patients: Long follow-up of single center randomized study R. Abo

More information

DOMINICAN HOSPITAL QUALITY IMPROVEMENT STUDY BREAST CANCER CARE

DOMINICAN HOSPITAL QUALITY IMPROVEMENT STUDY BREAST CANCER CARE DOMINICAN HOSPITAL QUALITY IMPROVEMENT STUDY BREAST CANCER CARE STUDY COORDINATOR: Jimmy Chung, MD 234 Surgical breast cancer patients admitted 2004-2008 Updated: 10/7/10 INTRODUCTION Breast cancer is

More information

Appendix One. HER2-positive early breast cancer, its treatment and prognosis

Appendix One. HER2-positive early breast cancer, its treatment and prognosis Appendix One. HER2-positive early breast cancer, its treatment and prognosis Breast cancer and HER2/neu over-expression Health need is one of PHARMAC s nine decision criteria (http://www.pharmac.govt.nz/pdf/231205.pdf

More information

Pathologic Assessment Of The Breast And Axilla After Preoperative Therapy

Pathologic Assessment Of The Breast And Axilla After Preoperative Therapy Pathologic Assessment Of The Breast And Axilla After Preoperative Therapy W. Fraser Symmans, M.D. Associate Professor of Pathology UT M.D. Anderson Cancer Center Pathologic Complete Response (pcr) Proof

More information

Metastatic Cancer: Questions and Answers. Key Points

Metastatic Cancer: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Metastatic Cancer: Questions

More information

Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns

Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns July 2013 Edition Vol. 7, Issue 7 Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns By Julie Katz, MPH, MPhil Biomarkers played a prominent role in the research presented in

More information

ASCO CAP HER2 Test Guideline Recommendations Summary of Guideline 2007 and 2013 Recommendations

ASCO CAP HER2 Test Guideline Recommendations Summary of Guideline 2007 and 2013 Recommendations ASCO CAP HER2 Test Guideline Recommendations Summary of Guideline 2007 and 2013 Recommendations Topic 2007 Recommendation 2013 Recommendation Specimens to be tested algorithm for HER2 testing All primary

More information

ASCO-CAP Guidelines for Breast Predictive Factor Testing

ASCO-CAP Guidelines for Breast Predictive Factor Testing ASCO-CAP Guidelines for Breast Predictive Factor Testing M. Elizabeth Hammond MD Pathologist, Intermountain Healthcare Professor of Pathology, University of Utah School of Medicine Agenda Why ASCO-CAP

More information

Overview of Breast Cancer. Donna Graham Medical Oncology SpR

Overview of Breast Cancer. Donna Graham Medical Oncology SpR Overview of Breast Cancer Donna Graham Medical Oncology SpR Learning Points Epidemiology Risk Factors Diagnosis Prognostic Markers Stage 0 III disease Stage IV disease Surveillance Incidence in Ireland

More information

Ovarian Cancer. in Georgia, 1999-2003. Georgia Department of Human Resources Division of Public Health

Ovarian Cancer. in Georgia, 1999-2003. Georgia Department of Human Resources Division of Public Health Ovarian Cancer in Georgia, 1999-23 Georgia Department of Human Resources Division of Public Health Acknowledgments Georgia Department of Human Resources......B. J. Walker, Commissioner Division of Public

More information

Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma

Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma Medical Expert: Breast Rotation Specific Competencies/Objectives 1.0 Medical History

More information

October is Breast Cancer Awareness Month!

October is Breast Cancer Awareness Month! October is Breast Cancer Awareness Month! A STUDY OF CHARACTERISTICS AND MANAGEMENT OF BREAST CANCER IN TAIWAN Eric Kam-Chuan Lau, OMS II a, Jim Yu, OMSII a, Christabel Moy, OMSII a, Jian Ming Chen, MD

More information

Understanding Your Breast Cancer Pathology Report *

Understanding Your Breast Cancer Pathology Report * Understanding Your Breast Cancer Pathology Report * * Note: Your pathology report may contain all or some of the sections covered in this guide. Remember, your healthcare team is always available to help

More information

Sentinel Lymph Node Biopsy: Questions and Answers. Key Points

Sentinel Lymph Node Biopsy: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Sentinel Lymph Node Biopsy:

More information

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics

Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Prognosis of Patients With Breast Cancer: Causes of Death and Effects of Time Since Diagnosis, Age, and Tumor Characteristics Edoardo Colzani, M.D., M.P.H. Department of Medical Epidemiology and Biostatistics

More information

Temario- speakers. Management of the axilla in local and / or regional recurrence Manejo de la axila en la recurrencia local y / regional.

Temario- speakers. Management of the axilla in local and / or regional recurrence Manejo de la axila en la recurrencia local y / regional. 16.08.11 Henry Kuerer MD, PhD, FACS Director Breast SurgicalOncology University of Texas MD Anderson Cancer Center. Houston, TX Re-excision in local recurrence after conservative therapy Retumorectomía

More information

BREAST CANCER IN YOUNG AGE ( 40 YEARS): THE UNIVERSITY OF TENNESSEE MEDICAL CENTER AT KNOXVILLE 10 YEAR EXPERIENCE

BREAST CANCER IN YOUNG AGE ( 40 YEARS): THE UNIVERSITY OF TENNESSEE MEDICAL CENTER AT KNOXVILLE 10 YEAR EXPERIENCE BREAST CANCER IN YOUNG AGE ( 40 YEARS): THE UNIVERSITY OF TENNESSEE MEDICAL CENTER AT KNOXVILLE 10 YEAR EXPERIENCE Snyder D, Heidel RE, Panella T, Bell J, Orucevic A University of Tennessee Medical Center

More information

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D.

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D. Prognostic and Predictive Factors in Oncology Mustafa Benekli, M.D. NCI Definitions ESMO Course -Essentials of Medical Oncology -Istanbul 2 Prognostic factor: NCI Definition A situation or condition, or

More information

Issued: September 2013. NICE diagnostics guidance 10. www.nice.org.uk/dg10

Issued: September 2013. NICE diagnostics guidance 10. www.nice.org.uk/dg10 Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostrat Issued: September

More information

Triple Negative Breast Cancer, 2014: Expert Perspectives

Triple Negative Breast Cancer, 2014: Expert Perspectives Triple Negative Breast Cancer, 2014: Expert Perspectives A Guide for Patients This guide is based on an expert panel discussion titled "Triple Negative Breast Cancer: Practical Treatment Strategies," developed

More information

Receptor conversion in distant breast cancer metastases. Breast cancer metastases: A spitting image of their primary?

Receptor conversion in distant breast cancer metastases. Breast cancer metastases: A spitting image of their primary? Receptor conversion in distant breast cancer metastases Breast cancer metastases: A spitting image of their primary? Introduction Breast cancer is the leading cause of female cancer death worldwide (13,000

More information

Breast Cancer. The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer.

Breast Cancer. The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer. Breast Cancer What Does the Pathology Report Say Normal Cells The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer. Non-Invasive

More information

Male breast cancer - Wikipedia, the free encyclopedia

Male breast cancer - Wikipedia, the free encyclopedia pagina 1 van 5 Male breast cancer From Wikipedia, the free encyclopedia Male breast cancer is a relatively rare cancer in men that originates from the breast. As it presents a similar pathology as female

More information

GENERAL QUESTIONS FOR YOUR DOCTOR OR NURSE. 3. Can you refer me to a breast cancer support group or counselor?

GENERAL QUESTIONS FOR YOUR DOCTOR OR NURSE. 3. Can you refer me to a breast cancer support group or counselor? GENERAL QUESTIONS FOR YOUR DOCTOR OR NURSE 1. You can bring members of your family or a friend to talk to the doctor or nurse directly. 2. Where can I find more information about breast cancer? 3. Can

More information

WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES

WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES WHI - Volume 8, Section 4 - Outcome Classifications: Cancer Outcomes Page 4-1 SECTION 4 OUTCOME CLASSIFICATIONS: CANCER OUTCOMES INTRODUCTION Breast and colorectal cancers are primary outcomes of the Dietary

More information

ENDORSEMENT SUMMARY: Cancer Measures

ENDORSEMENT SUMMARY: Cancer Measures OCTOBER 2012 Purpose of the Project Cancer defined by the National Institutes of Health as a group of more than 100 diseases characterized by uncontrolled cellular growth, proliferation, and spread has

More information

Monitoring Soluble HER2 Levels in Patients with Metastatic Breast Cancer

Monitoring Soluble HER2 Levels in Patients with Metastatic Breast Cancer Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

Breast Cancer. The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer.

Breast Cancer. The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer. Breast Cancer What Does the Pathology Report Say Normal Cells The Pathology report gives an outline on direction of treatment. It tells multiple stories to help us understand the patient s cancer. Non-Invasive

More information

The Diagnosis of Cancer in the Pathology Laboratory

The Diagnosis of Cancer in the Pathology Laboratory The Diagnosis of Cancer in the Pathology Laboratory Dr Edward Sheffield Christmas Select 74 Meeting, Queen s Hotel Cheltenham, 3 rd December 2014 Agenda Overview of the pathology of cancer How specimens

More information

Hereditary Multifocal Breast Cancer. Farin Amersi M.D., F.A.C.S Division of Surgical Oncology Department of Surgery Cedar Sinai Medical Center

Hereditary Multifocal Breast Cancer. Farin Amersi M.D., F.A.C.S Division of Surgical Oncology Department of Surgery Cedar Sinai Medical Center Hereditary Multifocal Breast Cancer Farin Amersi M.D., F.A.C.S Division of Surgical Oncology Department of Surgery Cedar Sinai Medical Center CASE STUDY 30 year old Ashkenazi Jewish woman Nulliparous Felt

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

New Treatment Advances for Breast Cancer

New Treatment Advances for Breast Cancer New Treatment Advances for Breast Cancer Guest Expert: Lyndsay, MD Director of the Yale Cancer Center Breast Cancer Program Gina ng, MD www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center

More information

Treatment of Metastatic Breast Cancer: Endocrine Therapies. Robert W. Carlson, M.D. Professor of Medicine Stanford University

Treatment of Metastatic Breast Cancer: Endocrine Therapies. Robert W. Carlson, M.D. Professor of Medicine Stanford University Treatment of Metastatic Breast Cancer: Endocrine Therapies Robert W. Carlson, M.D. Professor of Medicine Stanford University MDACC Experience with FAC in Chemotherapy-Naive MBC Greenberg et al, J Clin

More information

HAVE YOU BEEN NEWLY DIAGNOSED with DCIS?

HAVE YOU BEEN NEWLY DIAGNOSED with DCIS? HAVE YOU BEEN NEWLY DIAGNOSED with DCIS? Jen D. Mother and volunteer. Diagnosed with DCIS breast cancer in 2012. An educational guide prepared by Genomic Health This guide is designed to educate women

More information

HER2 Testing in Breast Cancer

HER2 Testing in Breast Cancer HER2 Testing in Breast Cancer GAIL H. VANCE, M.D. AGT MEETING JUNE 13, 2014 LOUISVILLE, KENTUCKY No Conflict of Interest to Report Human Epidermal Growth Factor Receptor 2-HER2 Human epidermal growth factor

More information

MEDICAL POLICY EFFECTIVE DATE: 07/20/06 REVISED DATE: 10/18/07, 10/23/08, 10/29/09, 10/28/10, 03/17/11, 02/16/12, 01/17/13, 01/16/14

MEDICAL POLICY EFFECTIVE DATE: 07/20/06 REVISED DATE: 10/18/07, 10/23/08, 10/29/09, 10/28/10, 03/17/11, 02/16/12, 01/17/13, 01/16/14 MEDICAL POLICY SUBJECT: HER-2 TESTING IN INVASIVE BREAST OR PAGE: 1 OF: 6 If the member's subscriber contract excludes coverage for a specific service it is not covered under that contract. In such cases,

More information

Breast cancer. A guide for journalists on breast cancer and its treatment

Breast cancer. A guide for journalists on breast cancer and its treatment Breast cancer A guide for journalists on breast cancer and its treatment Contents Contents 2 3 Section 1: Breast Cancer 4 i. What is breast cancer? 4 ii. Types of breast cancer 4 iii. Causes and risk factors

More information

Breast Cancer. CSC Cancer Experience Registry Member, breast cancer

Breast Cancer. CSC Cancer Experience Registry Member, breast cancer ESSENTIALS Breast Cancer Take things one step at a time. Try not to be overwhelmed by the tidal wave of technical information coming your way. Finally you know your body best; you have to be your own advocate.

More information

Cancer is the leading cause of death for Canadians aged 35 to 64 and is also the leading cause of critical illness claims in Canada.

Cancer is the leading cause of death for Canadians aged 35 to 64 and is also the leading cause of critical illness claims in Canada. Underwriting cancer In this issue of the Decision, we provide an overview of Canadian cancer statistics and the information we use to make an underwriting decision. The next few issues will deal with specific

More information

BREAST CANCER PATHOLOGY

BREAST CANCER PATHOLOGY BREAST CANCER PATHOLOGY FACT SHEET Version 4, Aug 2013 This fact sheet was produced by Breast Cancer Network Australia with input from The Royal College of Pathologists of Australasia I m a nurse and know

More information

A guide for women who are considering breast cancer treatment with chemotherapy and/or hormonal therapy before surgery

A guide for women who are considering breast cancer treatment with chemotherapy and/or hormonal therapy before surgery A guide for women who are considering breast cancer treatment with chemotherapy and/or hormonal therapy before surgery Contents Introduction... 1 What type of breast cancer do I have?... 2 What treatments

More information

What is breast cancer?

What is breast cancer? Breast Cancer What is breast cancer? Let us explain it to you. www.anticancerfund.org www.esmo.org ESMO/ACF Patient Guide Series based on the ESMO Clinical Practice Guidelines BREAST CANCER: A GUIDE FOR

More information

Breast Cancer Recurrence Assay (MammaPrint )

Breast Cancer Recurrence Assay (MammaPrint ) Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance

More information

BreastCancerTrials.org History Form: Metastatic Breast Cancer ABOUT ME

BreastCancerTrials.org History Form: Metastatic Breast Cancer ABOUT ME BreastCancerTrials.org History Form: Metastatic Breast Cancer This form is for patients with metastatic breast cancer who were: Were recently diagnosed with metastatic breast cancer (cancer that has spread

More information

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR.

SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. SECOND PRIMARY BREAST CANCERS FOLLOWING HAEMATOLOGIC MALIGNANCIES A CASE SERIES STUDY FARAH TANVEER PGY 3 DR.MEIR WETZLER DR. TRACEY O CONNOR RESEARCH QUESTON Patients with previously diagnosed hematologic

More information

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer

Treating Patients with Hormone Receptor Positive, HER2 Positive Operable or Locally Advanced Breast Cancer Breast Studies Adjuvant therapy after surgery Her 2 positive Breast Cancer B 52 Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients with Hormone

More information

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Lotte Holm Land MD, ph.d. Onkologisk Afd. R. OUH Kræft og komorbiditet - alle skal

More information

Metastatic Breast Cancer...

Metastatic Breast Cancer... DIAGNOSIS: Metastatic Breast Cancer... What Does It Mean For You? A diagnosis of metastatic breast cancer can be frightening. It raises many questions and reminds us of days past when cancer was such a

More information

Surgical Margins and follow up of Squamous Cell Carcinoma. Steve Keohane

Surgical Margins and follow up of Squamous Cell Carcinoma. Steve Keohane Surgical Margins and follow up of Squamous Cell Carcinoma Steve Keohane Poor registration Well established projected increase in incidence for next 2 decades Significant morbidity but relatively low mortality

More information

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014 General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention

More information

Number. Source: Vital Records, M CDPH

Number. Source: Vital Records, M CDPH Epidemiology of Cancer in Department of Public Health Revised April 212 Introduction The general public is very concerned about cancer in the community. Many residents believe that cancer rates are high

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

Diagnostics guidance Published: 25 September 2013 nice.org.uk/guidance/dg10. NICE All rights reserved.

Diagnostics guidance Published: 25 September 2013 nice.org.uk/guidance/dg10. NICE All rights reserved. Gene expression profiling and expanded immunohistochemistry tests for guiding adjuvant chemotherapy decisions in early breast cancer management: MammaPrint, Oncotype DX, IHC4 and Mammostratat Diagnostics

More information

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer J.-L. Zhang, Q. Yao, J.-H. Chen,Y. Wang, H. Wang, Q. Fan, R. Ling, J. Yi and L. Wang Xijing Hospital Vascular Endocrine

More information

BreastCancerTrials.org History Form: Completed Treatment for Breast Cancer ABOUT ME

BreastCancerTrials.org History Form: Completed Treatment for Breast Cancer ABOUT ME BreastCancerTrials.org History Form: Completed Treatment for Breast Cancer This form is for patients with DCIS or early stage invasive cancer who are: On hormone therapy after breast cancer surgery Or

More information

SAMO FoROMe Post-ESMO 2013 Breast Cancer

SAMO FoROMe Post-ESMO 2013 Breast Cancer SAMO FoROMe Post-ESMO 2013 Breast Cancer Dr. med. Manuela Rabaglio Klinik und Poliklinik für Medizinische Onkologie Breast Cancer Track 300 Abstracts 142 Poster 11 Proffered paper 4 late breaking news

More information

2016 Physician Quality Reporting System Data Collection Form: Oncology (for patients aged 18 and older)

2016 Physician Quality Reporting System Data Collection Form: Oncology (for patients aged 18 and older) 2016 Physician Quality Reporting System Data Collection Form: Oncology (for patients aged 18 and older) IMPTANT: Any measure with a 0% performance rate (100% for inverse measures) is not considered satisfactory

More information

TNM staging and prognosis. Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania

TNM staging and prognosis. Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania TNM staging and prognosis Alexandru Eniu, MD, PhD Medical Oncologist Department of Breast Tumors Cancer Institute Ion Chiricuţă Cluj-Napoca, Romania The Basics of TNM Staging Premises: Cancers of the same

More information

Outline. Workup for metastatic breast cancer. Metastatic breast cancer

Outline. Workup for metastatic breast cancer. Metastatic breast cancer Metastatic breast cancer Immunostain Update: Diagnosis of metastatic breast carcinoma, emphasizing distinction from GYN primary 1/3 of breast cancer patients will show metastasis 1 st presentation or 20-30

More information

SUMMARY. Sentinel Lymph Node Biopsy in Breast Cancer Treatment : Indications and Contraindications. Summary of the report prepared by Cathy Gosselin

SUMMARY. Sentinel Lymph Node Biopsy in Breast Cancer Treatment : Indications and Contraindications. Summary of the report prepared by Cathy Gosselin SUMMARY Sentinel Lymph Node Biopsy in Breast Cancer Treatment : Indications and Contraindications March 2012 A production of the Institut national d excellence en santé et en services sociaux Summary of

More information

A Checklist for Patients with Breast Cancer

A Checklist for Patients with Breast Cancer A Checklist for Patients with Breast Cancer Questions to Ask the Doctor 1 and Quick Help Resources 1 Adapted from: American Cancer Society. Detailed Guide: Breast Cancer - What Should You Ask Your Doctor

More information

Understanding your pathology report

Understanding your pathology report Understanding your pathology report 2 Contents Contents Introduction 3 What is a pathology report? 3 Waiting for your results 4 What s in a pathology report? 4 Information about your breast cancer 5 What

More information

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div. Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under

More information

Fact Sheet: Molecular Imaging and Cancer

Fact Sheet: Molecular Imaging and Cancer Fact Sheet: Molecular Imaging and Cancer Cancer causes one in every four deaths in the United States, second only to heart disease. According to the American Cancer Society, an estimated 1.48 million new

More information

HER2-Positive Male Breast Cancer with Thyroid Cancer: an Institutional Report and Review of Literature

HER2-Positive Male Breast Cancer with Thyroid Cancer: an Institutional Report and Review of Literature Annals of Clinical & Laboratory Science, vol. 42, no. 2, 2012 Available online at www.annclinlabsci.org 135 HER2-Positive Male Breast Cancer with Thyroid Cancer: an Institutional Report and Review of Literature

More information

Oncotype-DX gene expression profile and chemotherapy decision-making in patients with early stage breast cancer

Oncotype-DX gene expression profile and chemotherapy decision-making in patients with early stage breast cancer Irish Society of Medical Oncology Evidence-based Series #1 Oncotype-DX gene expression profile and chemotherapy decision-making in patients with early stage breast cancer C.M Kelly and Members of the Irish

More information

Ductal Carcinoma WHITE PAPER

Ductal Carcinoma WHITE PAPER WHITE PAPER Introduction Breast Cancer is one of the most common and second largest causes of cancer death in women after lung cancer. Fortunately, the decline in death rate from breast cancer is thought

More information

Mercy Cancer Center Annual Performance and Outcomes Report. Approved by: Cancer Center Leadership Team. May 20, 2014

Mercy Cancer Center Annual Performance and Outcomes Report. Approved by: Cancer Center Leadership Team. May 20, 2014 Mercy Cancer Center Annual Performance and Outcomes Report Approved by: Cancer Center Leadership Team May 20, 2014 Outline Quality measures (Commission on Cancer Quality Reporting Tools) Inpatient Market

More information

The best treatment Your guide to breast cancer treatment in England and Wales

The best treatment Your guide to breast cancer treatment in England and Wales The best treatment Your guide to breast cancer treatment in England and Wales If you are looking for information on the treatment of secondary breast cancer (also known as advanced or metastatic breast

More information

Laboratory Testing for Her2 Status in Breast Cancer

Laboratory Testing for Her2 Status in Breast Cancer Laboratory Testing for Her2 Status in Breast Cancer Katherine Geiersbach, M.D. Assistant Professor, Department of Pathology May 28, 2015 Overview Clinical relevance of Her2 status for treatment of breast

More information

Theories on Metastasis: Innovative Thinking An Advocacy Perspective

Theories on Metastasis: Innovative Thinking An Advocacy Perspective Theories on Metastasis: Innovative Thinking An Advocacy Perspective Project LEAD Workshop NBCC Annual Advocacy Conference 2011 Musa Mayer AdvancedBC.org 1 The Big Question If we want to end death from

More information

The Oncotype DX Breast Cancer Assay helps you find an answer

The Oncotype DX Breast Cancer Assay helps you find an answer CHEMO? NO CHEMO? The Oncotype DX Breast Cancer Assay helps you find an answer Oncotype DX helps clarify one of the most difficult treatment questions by providing an individualized Recurrence Score result

More information

Breast cancer treatments

Breast cancer treatments Breast cancer treatments i About us Breast Cancer Network Australia (BCNA) is the peak organisation for all people affected by breast cancer in Australia. We provide a range of free resources, including

More information

Frequently Asked Questions About Ovarian Cancer

Frequently Asked Questions About Ovarian Cancer Media Contact: Gerri Gomez Howard Cell: 303-748-3933 gerri@gomezhowardgroup.com Frequently Asked Questions About Ovarian Cancer What is ovarian cancer? Ovarian cancer is a cancer that forms in tissues

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Ado-Trastuzumab Emtansine (Trastuzumab-DM1) for Treatment of File Name: Origination: Last CAP Review: Next CAP Review: Last Review: ado_trastuzumab_emtansine_(trastuzumab-dm1)_for_treatment_of_her-2_positivemalignancies

More information

Now, there are multiple risk factors that may increase the risk for contralateral second primary breast cancers. Women diagnosed at a young age with a

Now, there are multiple risk factors that may increase the risk for contralateral second primary breast cancers. Women diagnosed at a young age with a Hello. My name is Suzanne Day. I am a nurse practitioner at The University of Texas MD Anderson Cancer Center. I m here today to talk about assessing risk and preventing second primary breast cancers.

More information

Cancer in Northeastern Pennsylvania: Incidence and Mortality of Common Cancers

Cancer in Northeastern Pennsylvania: Incidence and Mortality of Common Cancers Cancer in Northeastern Pennsylvania: Incidence and Mortality of Common Cancers Samuel M. Lesko, MD, MPH Medical Director Karen Ryczak, RN Surveillance Coordinator November 2015 334 Jefferson Avenue, Scranton,

More information

Update in Hematology Oncology Targeted Therapies. Mark Holguin

Update in Hematology Oncology Targeted Therapies. Mark Holguin Update in Hematology Oncology Targeted Therapies Mark Holguin 25 years ago Why I chose oncology People How to help people with possibly the most difficult thing they may have to deal with Science Turning

More information

Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013. National Registry of Diseases Office (NRDO)

Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013. National Registry of Diseases Office (NRDO) Singapore Cancer Registry Annual Registry Report Trends in Cancer Incidence in Singapore 2009 2013 National Registry of Diseases Office (NRDO) Released November 3, 2014 Acknowledgement This report was

More information

Breast Cancer Treatment

Breast Cancer Treatment Breast Cancer Treatment Most women with breast cancer will have surgery. The two common types of surgery are breast-conserving surgery and mastectomy. Breast Conserving Surgery A lumpectomy removes only

More information

Departments, Divisions, Operational Areas. Breast Surgery Medical Oncology Radiation Oncology

Departments, Divisions, Operational Areas. Breast Surgery Medical Oncology Radiation Oncology Oncology Clinical Service Line System-wide Consensus Guidelines: Postmastectomy Radiation for Patients with 1-3 Positive Lymph Nodes These guidelines apply to clinical interventions that have well-documented

More information

Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer

Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer Gemcitabine, Paclitaxel, and Trastuzumab in Metastatic Breast Cancer Review Article [1] December 01, 2003 By George W. Sledge, Jr, MD [2] Gemcitabine (Gemzar) and paclitaxel show good activity as single

More information

Patient Guide to Early-Stage Invasive Breast Cancer Surgery and Treatment

Patient Guide to Early-Stage Invasive Breast Cancer Surgery and Treatment Patient Guide to Early-Stage Invasive Breast Cancer Surgery and Treatment Deborah C. Animal rehabilitation specialist and avid athlete. Diagnosed with invasive breast cancer in 2007. An educational guide

More information

I would like to discuss risk factors and multi-steps involved in breast carcinogenesis and mechanisms of invasion and metastasis of breast cancer.

I would like to discuss risk factors and multi-steps involved in breast carcinogenesis and mechanisms of invasion and metastasis of breast cancer. Hello. My name is Ayse Sahin. I m a Professor of Pathology at University of Texas MD Anderson Cancer Center. I would like to review Pathology of Breast Cancer. Upon completion of this lecture, participants

More information

C a nc e r C e nter. Annual Registry Report

C a nc e r C e nter. Annual Registry Report C a nc e r C e nter Annual Registry Report 214 214 Cancer Registry Report Larraine A. Tooker, CTR Please note that the 214 Cancer Registry Annual Report is created in 214, but it reflects data on cases

More information

Impact of radiation therapy on survival in patients with triple negative breast cancer

Impact of radiation therapy on survival in patients with triple negative breast cancer 548 Impact of radiation therapy on survival in patients with triple negative breast cancer LAUREN T. STEWARD 1, FENG GAO 2, MARIE A. TAYLOR 3 and JULIE A. MARGENTHALER 1 1 Department of Surgery; 2 Division

More information

Improving survival and Clinical Trials Janyne Afseth Lecturer Edinburgh Napier University

Improving survival and Clinical Trials Janyne Afseth Lecturer Edinburgh Napier University Improving survival and Clinical Trials Janyne Afseth Lecturer Edinburgh Napier University Aims Identify the factors which may link to improved survival to clinical trials in cancer Describe some of impact

More information