INTERREG III B «Atlantic Area» FINAL REPORT FORM

Transcription

1 INTERREG III B Atlantic Area VALBIOMAR Final Report. With the participation of the European Union Project co-financed by the ERDF INTERREG III B «Atlantic Area» FINAL REPORT FORM PROJECT IDENTIFICATION CODE and ACRONYM: O45 - VALBIOMAR Biotechnological Exploitation of Marine Resources 1

2 INTERREG III B Atlantic Area VALBIOMAR Final Report. CONTENTS CONTENTS 2 INTRODUCTION 3 PROJECT IDENTIFICATION 4 EVALUATION OF THE WORKING OF THE PARTNERSHIP 5 TRANS-NATIONAL OBJECTIVES OF THE PROJECT 6 PROJECT OBJECTIVES 8 METHODOLOGY 9 ACTIONS CONDUCTED 11 ACTIONS CONDUCTED 12 ACTIONS CONDUCTED 12 ACTIONS CONDUCTED 21 ACTIONS CONDUCTED 24 INFORMATION AND COMMUNICATION 27 PROSPECTS 40 COMPLIANCE WITH THE GRANT OFFER LETTER and any addenda. 43 ANNEXE 1: PROJECT SCHEDULE AND KEY DATES 45 ANNEXE 2: FILING OF ORIGINAL SUPPORTING DOCUMENTS 46 ANNEXE 3: FILING OF KEY DOCUMENTS OF THE PROJECT 47 ANNEXE 4: SUMMARY OF ERDF PAID 48 ANNEXE 5: PROGRAMME INDICATORS 49 ANNEXE 6: PROJECT INDICATORS 50 ANNEXE 7: USEFUL CONTACTS 51 2

3 INTERREG III B Atlantic Area VALBIOMAR Final Report. INTRODUCTION The aim of the Final Report of the project is to gather together, in a single document, all the information about the results of each project co-financed within the framework of the INTERREG IIIB Atlantic Area Community Initiative Programme. It accompanies and completes the application for payment of the final balance. This report is an opportunity, for the Lead Partner and Partners, to take part in action to promote and disseminate the results of the programme. The information supplied will be used in the annual implementation report, as well as in the final programme report sent to the European Commission. In this way, by providing information on the working of the partnership, the action carried out and the results of the trans-national cooperation project, each project will contribute to the success of the programme. The Lead Partner must also take this opportunity to review the project steering and monitoring activities and ensure that each partner has the items and information required to provide evidence of the implementation of the project to the competent regional, national and European authorities. The purpose is to check that the audit trail has been complied with through to the final beneficiary of Community aid, including by filing all the supporting documents relating to implementation, achievements and ERDF payments. In order to facilitate this work, the Final Report is structured as follows: - Identification of the project and Lead Partner, - Evaluation of the steering of the trans-national project, - Reminder of the initial objectives and overall outcome of the project, - Review of the different trans-national actions and activities conducted to achieve these objectives, - Review of information and communication measures, - Prospects for the future, - Reminder of the main obligations and corresponding declaration of the Lead Partner, - A set of technical annexes on the project schedule, filing of supporting documents, follow-up of ERDF payments and of indicators. The purpose of this plan is to facilitate uniform processing of all this information for each of the projects. As far as the form of the document is concerned, the text zones and the number of actions conducted are provided as an indication only and may be extended if required. For each point, the part corresponding to the application form is indicated (NB: depending on the version of the form used. If they are different, the first number corresponds to the application form of the first call for proposals, and the second number to the one used for the second call for proposals). This final report must be prepared by the Lead Partner, possibly in liaison with the other partners, and must be examined jointly to ensure the accuracy and compliance of the information featured in it. Each partner in the project must be sent a copy by the Lead Partner. The national authorities responsible for the first-level (Article 4) control procedure will also be sent the report which will accompany the application for the final balance sent by each partner. The Lead Partner will transmit a copy to the Joint Secretariat at the same time as the application for the final balance of the project, in an electronic copy and a hard copy including the signature of the authorised person. For all questions or information about this report, the contact details of the Joint Secretariat and the National Correspondents are attached. This document is available in the four languages (French, Spanish, Portuguese and English) on the programme website: interreg-atlantique.org 3

4 INTERREG III B Atlantic Area VALBIOMAR Final Report. PROJECT IDENTIFICATION (Cf. Application Form point 1) PROJECT NUMBER:045 ACRONYM: VALBIOMAR NAME: Biotechnological Exploitation of Marine Resources PRIORITY: A, C MEASURE: A2, C3 NUMBER OF PARTNERS PER COUNTRY: ESP : 2 FR : 8 IRL : 0 PT : 2 UK : 1 LEAD PARTNER IDENTIFICATION (Cf. Application Form point 2.1) ORGANISATION OF THE LEAD PARTNER: University of La Rochelle NAME OF THE REPRESENTATIVE OF THE LEAD PARTNER: Jean-Michel POUYLLAU, President of the University ADDRESS: Technoforum Université de la Rochelle Av. A. Einstein LA ROCHELLE COUNTRY: France CONTACT DETAILS OF THE PERSON IN CHARGE OF DRAWING UP THIS REPORT ORGANISATION: Muséum national d Histoire Naturelle (MNHN) SURNAME AND FORENAME: Prof. Yves LE GAL ADDRESS: Station de Biologie Marine MNHN BP CONCARNEAU COUNTRY: France TELEPHONE NUMBER: 33 (0) FAX NUMBER: 33(0) [email protected] ORGANISATION: University of La Rochelle SURNAME AND FORENAME: Prof. Jean-Marie PIOT ADDRESS: LBCB - Technoforum Université de la Rochelle Av. A. Einstein LA ROCHELLE COUNTRY: France TELEPHONE NUMBER: 33 (0) FAX NUMBER: 33(0) [email protected] 4

5 INTERREG III B Atlantic Area VALBIOMAR Final Report. EVALUATION OF THE WORKING OF THE PARTNERSHIP (Cf. Application Form 11 and 3.12) PROJECT STEERING STRUCTURE: List the different Committees and groups formed and briefly define their working. COMMITTEE ACTIVITIES POSITION EXPERTS ORGANISATION General manager Prof. Jean-Marie PIOT University la Rochelle Financial manager Marie-Grace TEIXEIRA then Brigitte ALBERT (oct06- dec06) University la Rochelle Administrative and financial management Scientific and technical management 1. Administrative and financial business 2. Responsibility of reports and control of the realised activities 3. Animation of the consortium by scheduling of general meetings To insure the correct unwinding and advancement of activities: 1. Networking of laboratories 2. Achievement of training and information to SMEs 3. Coordination of laboratory- SME projects 4. Dissemination Assistant manager Christelle BELLENGER then Laurence GAREAUX (oct05- dec06) RUOA 1 administrative responsible per partner Scientific manager Prof. Yves LE GAL MNHN SME manager Marisa FERNANDEZ CETMAR Communication manager Maëlle ROBIN 1 technical responsible per partner Technopole Quimper- Cornouaille PROJECT STEERING (Cf. Application Form point 8 and 3.7) SCHEDULE OF MEETINGS AND ACTIVITIES OF THE STEERING STRUCTURES (Type of communication and frequency) Administrative and financial management: Monthly meetings, weekly phone calls and internet communications Scientific and technical management: Monthly or weekly phone calls, internet communications. With specific partners for setting up of R&D actions, transfer operations to industries, training, dissemination, etc.: meetings WORKING OF THE PARTNERSHIP POSITIVE, NEGATIVE ASPECTS AND POINTS THAT COULD BE IMPROVED... The partnership of VALBIOMAR was well equilibrated in terms of balance of activities (R&D, training, communication). The collaboration between the teams was very good as shown by the running of a number of collaborative, cross-border joint operations. Clearly, it was very positive and it helps the creation of an Atlantic transnational network in marine biotechnology with people that face same technological issues in four regions concerned by the project. The only major difficulties arose from financial questions due essentially to the complexity of the Interreg machinery at different steps and the rather long delays in approving and in recovering the money. This drawback had a negative effect for some partners, particularly on the possibility of travelling of some partners. 5

6 INTERREG III B Atlantic Area VALBIOMAR Final Report. TRANS-NATIONAL OBJECTIVES OF THE PROJECT (Cf. Application Form point 3.4) Reminder of the expected results The VALBIOMAR objectives and expected achievements were: - The setting up of a network of laboratories for the achievement of tasks and the combination of researches in the field of fisheries and aquaculture by-products up-grading: to coordinate the exploitation of biological marine resources; to develop and strengthen the technology, to use new and credible techniques in the field of biotechnological evaluation on sea products; to enable and support the development of commercial activities on the small and medium scale in this sector. - The creation of an Atlantic inter-regional Platform for technology transfer and communication, close to SMEs of the Fishing activities and the sea products, in relation with the centres still in operation The organisation of adapted training and information sessions for SMEs willing to insert the results in their industry. Description of the results achieved On the three points, one can consider that the VALBIOMAR project has been really fully successful: - The different laboratories and technical centres of the project have been able to carry out mutual works and projects in the field of the treatment and upgrading of marine by-products. An important part of the processes developed during the project correspond to specific requests of SMEs. - The Atlantic inter-regional Platform for technology transfer and communication is operative, with different ways of communication (leaflets, website, communication during specialized exhibitions, one-to-one contact etc). Several training and information sessions have been organised in the different countries and for some of them in a trans-national way. These sessions were very successful with the participating SMEs. In addition, a Virtual Learning Tool (e-learning) has been developed with the participation of all partners and under the organisation and coordination of CETMAR. Contribution of trans-national cooperation to the ADDED VALUE of the project. Give a figure from 1 (negative) to 4 (remarkable) and explain your choice VALBIOMAR addresses the implementation of a transnational network (Spain (Galicia, Canarias), France (Brittany, Pays de la Loire, Poitou-Charentes), United Kingdom (Scotland) and Portugal based on shared problems and common needs. All the regions have close links to the sea and its resources, and each economy has to face similardifficulties. In terms of scientific skills and competences, VALBIOMAR revealed large areas where the different partners (process technologies, type of starting material, by-products and final products) were fully complementary. This complementary character proves to be a positive point for responding to SMEs inquiries. SMEs from the four regions face the same issues concerning how to use by-products and what development could be viable regarding marine resources. The laboratories helped the Atlantic SMEs to better know their possibility in terms of added value products elaboration. The market concerned by the biotechnological exploitation of marine resources is presently rising and VALBIOMAR helped the Atlantic area fully to realise the potential existing in the following domains: annual and human nutrition, nutraceutics, cosmetics and also naval industry. In terms of communication, all the group benefited from the experience of the transfer partners specialized in this domain. VALBIOMAR reinforced the technical co-operation on the basis of complementarity and established a network for the creation of a competitive and internationally recognised scientific and technical centre of excellence. 6

7 INTERREG III B Atlantic Area VALBIOMAR Final Report. INNOVATIVE ASPECTS (Cf. Application Form point 3.3) The innovative aspects of the project are triple: 1. Access and exploitation of marine biodiversity. In spite of the richness of their biodiversity (compared to terrestrial living resources), marine living resources are relatively little exploited and are under-developed. The situation in Europe in this respect contrast markedly with that of other countries with maritime ambitions such as Japan, Australia, Canada or USA which developed ambitious programs for the screening of natural substances produced by tropical marine organisms. The uniqueness of marine faunas and floras of the Eastern Atlantic coast makes possible the development of original products with commercial potential in various fields of food industry (nutraceuticals), pharmaceuticals and surface technologies that are different from that originating of other oceanic zones and capable of being exploited locally Concerning marine biomass and co-products, the research laboratories involved in the project have been establishing new methods of biotechnological hydrolytic treatments, generating high added value molecules harbouring specific potential in various domains of food, feeding, health. Jointly, the knowledge produced by these laboratories represents a unique and very serious innovative force making possible a better use of fished biomass and the release of new marketable products. 3. One important part of the project is devoted to the setting up of an efficient medium carrying out not only communication and technology transfer tasks but also a real networking between R/D centers and SMEs which are generally small-sized and scattered. The project has received a very real and positive response from SME s. Within the domains of the project, Atlantic SME s have had relatively little access to innovating technologies developed during the last decade. The objective of the project was firstly to make all the concerned aware of the possibilities of cooperation with the laboratories in the domains of biotechnology of marine resources and of the potential of industrial applications. The consortium established as a policy to give access to the work and results of laboratories without any limitation and, thus, to did not involve or gave preference to any specific SME. On the contrary, the consortium integrates technology transfer centers well settled in the economic tissue and well aware of the activities of the SME s in their regions that were likely to be interested in the project. The transfer centers were responsible for the contacts between SME s of their regional area and the Valbiomar researchers. They have networked with other public bodies. The transfer centers have linked SME s and laboratories through seminars, conferences, mailshots and personal contacts etc. They have helped them to formulate cooperation agreements and coordinate the work to be carried out by the partners. Thus, the number of cooperation agreements signed with SME s was more important, as the consortium was not limited to already interested SME s. The main issue addressed by the VALBIOMAR project related to the necessity, in a context of rarefaction of exploited marine resources, to optimize the operations of transformation of the raw materials and up-grading of co-products. We estimate that the VALBIOMAR project, by creating synergies between the specialised laboratories and local industries and by increasing also communication and technology transfer from science centres to SMEs, has strongly increased the innovation capacity of small sized and often traditional enterprises in the partners regions. This in turn will have helped and continue to help such enterprises become more competitive. Number of job creations FORECAST Number of job creations ACHIEVED Men Women Men 2 3 Women Considering the exploratory character of Valbiomar project, it had not been possible to determine in advance the number of job creation. Presently, the number of job creation derived from the project can not be estimated precisely as they occurs mainly in SME s affiliated to the project, and therefore can be considered as indirect jobs. Among Valbiomar partner s : a first evaluation including postgraduates engaged on specific industrial projects gives a number of 5. 7

8 INTERREG III B Atlantic Area VALBIOMAR Final Report. PROJECT OBJECTIVES (Cf. Application Form point 3.5 and 3.8) Reminder of the objectives and of the main results achieved The expected results of this project were both short and long term. 1. In the short term, the partner s expectations were to set up real exchanges between researchers and the SMEs on the Atlantic area on the topic of marine bio-products. The corresponding results have two components: - The coordination of the different research teams on the Atlantic Area permitted a range of actions and joint-research allowing the exchange and improvement of extraction, purification and biotransformation techniques; the joint access to marine resources as, for example, marine fauna and flora of the Atlantic coast and the islands and information on the fisheries and aquaculture industries of each area. The various laboratory partners networked well for the realisation of tests for biological activities; - The development of a scientific and technical force credible at the European level in the fields of marine biotechnologiy and particularly the upgrading of marine bio-products. This force includes the researchers and the SME s (availability of a common tool the platform to settle the awareness of the SME and train them on the insertion of marine bio-products in their own products). 2. Other objectives were long term: On the economic plan, this project fits in the declining fisheries and marine productivity by proposing a diversification based on the development of new products in the sectors of the nutrition, health (production of "health-food") and of industrial microbiology. The centres of expertise and networks developed during the realisation of this study will make it possible to tackle thereafter other subjects of new marine bio-product development with greater effectiveness. 3. Communication with industrial partners of the Atlantic Arc, organizing information and practical training sessions allowed the integration of industrial specialists into certain projects which brought the program the expertise necessary for ensuring its economic relevance. Several programs are now developed with specific industries, particularly in relation to nutraceutical products. 8

9 INTERREG III B Atlantic Area VALBIOMAR Final Report. METHODOLOGY (Cf. Application Form point 3.5/3.7 and 3.5/3.6) Description of the methodology, with the links between the objectives and actions. The project was shared in five actions. There are listed here below with assignment of tasks to certain partners. At the time of the proposal, it was planned that ONLY SOME partners will participate in each action (1 to 5). It was also written in article 5 of the Grant Letter. During the achievement of the actions, VALBIOMAR partners realised that all the partners have to take part in the various actions : In action 1 : University of La Rochelle and Ruoa have been assisted by the MNHN (scientific coordinator) and Technopole Quimper Cornouaille. In action 2, it was planned that the research partners (University La Rochelle, IFREMER, Muséum National d Histoire Naturelle, University of Bretagne Occidentale, IPIMAR, Integrin, Université of Nantes, Université Bretagne Sud, University la Laguna) have to achieve the action but transfer partners (CETMAR, Alicontrol, Integrin, Technopole Quimper-Cornouaille) helped them to better define the results and research that could be transferred to the SMEs (Questionnaire, labs leaflets frame). In action 3, it was planned that the transfer partners have to organise information and training sessions to SMEs. But the contents were often done by the research centres as they were the speakers. 1- Management of the projet Leader Partners Period Objectives University la Rochelle assisted by RUOA (Réseau des Universités de l Ouest Atlantique) All M1-M36 This action aims to coordinate the project at the administrative and technical levels in order to carry out all activities scheduled at the end of VALBIOMAR. Achieved actions: In addition to the very regular phone and internet communication, two main general meetings of two full days gathering all partners were organised each year. Available deliverables: Partnership agreement, Reports on intermediary activities, Intermediary financial Reports, A comprehensive mid-term report, Final Report, Minutes of each transnational meetings. 2- Pooling of the technological achievements and definition of industrial possibilities Leader Partners Period Objectives University la Rochelle assisted by MNHN (Muséum National d Histoire Naturelle) University La Rochelle, IFREMER, Muséum National d Histoire Naturelle, University Bretagne Occidentale, IPIMAR, Integrin, Université of Nantes, Université Bretagne Sud, University la Laguna M1 M12 This phase should allow the laboratories of the different regions to pool their technological work and adapt them to the needs of industries Achieved actions: This phase allowed the laboratories to analyze the availability of resources, raw materials, and co-products in the considered geographical area. Results from different laboratories working within the project have been transferred to SMEs of the different regions either directly or after adaptation to the industrial constraints. The technologies involved in these transfers are: extraction and identification process of natural substances, transformation and refining process. Adaptation of laboratory processes to pilot scale activities, ; Functional foods ; Web based traceability systems. In addition, these common activities lead to the creation of a long-term network and the elaboration of joint R&D activities and expertises between members of the network. Available deliverables: Report on resources and co-products in Atlantic area, Analysis of which results from laboratories and which technological services could be transfered to SMEs, Leaflets on the competences of each lab for SMEs. Scientific publications, Exchange of good practices between laboratories. 9

10 INTERREG III B Atlantic Area VALBIOMAR Final Report. 3 - Information of SMEs on the advancement of work and possible adaptations Leader Partners Period Objectives CETMAR CETMAR, Alicontrol, Integrin, Technopole Quimper-Cornouaille Other partners M6 M30 SMEs are not fully aware of the possibilities of the laboratories and of their results. Communication activities will thus raise up their interest and inform tem about marine biotechnologies. Achieved actions: The aim was to fill in the gap deficit of communication between laboratories and SMEs of the different regions. In collaboration with the laboratories, the transfer centres facilitated the networking of SMEs, generally well-known by the tranfer centres in the project. Actions: Building of databases of SME contacts in each region; implementation and diffusion of an Research/Industry information platform focused on marine biotechnologies and targeted on SMEs and also on the research centres (SMEs database, leaflets, websites ); Organisation of information and training sessions for SMEs; On-line training for specialised uses ; Coordination of Lab/SMEs relationships. Available deliverables: A general VALBIOMAR leaflet especially dedicated to SMEs, SMEs database in the four regions, training and information sessions information packs (invitation, programmes, presentations, list of participants, satisfaction questionnaires ), VALBIOMAR Virtual Learning Tool, surveys. 4 - Cooperation between laboratories and SMEs and specific developments Leader Partners Period Objectives University Bretagne Occidentale All M12 M36 To allow real cooperations between laboratories and SMEs. To insure that the results already obtained will be effectively used by industry. Achieved actions: Contacts of SMEs requesting specific development were sent by the transfer centres to the laboratories. They then replied to SMEs questions and undertook research directly for SME s in the specific development area requested. Because of commercial confidentiality, the VALBIOMAR consortium is not allowed to specifically detail this action but a number of these interactions are on-going. Available deliverables: Agreements between SMEs and laboratories were signed. 5 - Communication Leader Partners Period Objectives Technopole Quimper-Cornouaille All partners M1 M36 To promote Atlantic regions as European Quality centre ( Labs and industries) in the different domains of biotechnical exploitation of marine ressources. Achieved actions: Local and international diffusion, Website, Information in specialised magazines, Press File, Press Conference Available deliverables: Communication Plan, Press kit, Press articles, VALBIOMAR results synthesis 10

11 INTERREG III B Atlantic Area VALBIOMAR Final Report. ACTIONS CONDUCTED (Cf. Application Form point 3.7 and 3.5) Action NATURE OF THE ACTION 1 Management of the projet - Leader : University of La Rochelle & Ruoa Expected results (according to the Application Form) This action aimed to coordinate the project at the administrative and technical levels in order to carry out all activities scheduled at the end of VALBIOMAR. The management outcome was the successful cohesion of the group throughout the project and also the delivery of reports. Describe the way in which the action was implemented In addition to frequent phone and internet communication, two main general meetings of two full days gathering all partners were organised each year. Partners involved in implementing the action Partner name Country Role in implementing the action Place(s) implemented ULR F General Manager RUOA F Assistant Manager - Administration MNHN F Scientific manager All other partners F, SP, Pt, UK Description of the results achieved Partnership agreement Reports on intermediary activities / Intermediary financial reports A comprehensive mid-term report / Final report Minutes of each transnational meetings Power-point presentations on administrative and financial issues (in English) Steering Committees Partners guidelines on administrative and financial issues delivered to each participant (in English and French) - Lisbon and Concarneau Steering Commitees (2006) Meetings with Interreg Secretariat Internal meetings and communication between partners Assistance to the transnational project meetings Support for English translations of reports (Integrin) Key dates of the action Kick-off Committee 2004 February La Rochelle France Transnational Seminar 2004 February 19 Interreg III B) partners - Poitiers - France Steering Committee 2004 Nov Vigo - Spain Steering Committee 2005 April Oban Scotland UK Steering Committee 2005 Oct Granville France Administrative meeting 2006 April 19 Poitiers France Ruoa with Interreg Secretariat Interreg Conference 2006 April 26 Dublin - Ireland Steering Committee 2006 May Lisbon - Portugal Administrative meeting 2006 June 12 La Rochelle Ruoa / Lead Partner financial officer Steering Committee 2006 Sept Concarneau France Administrative meeting 2006 Sept. 27 La Rochelle Ruoa / Lead Partner new financial officer Final Report meeting 2007 Febuary Quimper Ruoa / MNHN / TQC Justification of any discrepancies between the action as planned and as implemented, if any Achievements in conformity with the programme Total cost of the action (in Euros) including VAT : ,12 11

12 INTERREG III B Atlantic Area VALBIOMAR Final Report. ACTIONS CONDUCTED (Cf. Application Form point 3.7 and 3.5) Action NATURE OF THE ACTION 2 Pooling of the technological achievements and definition of industrial possibilities Leader : University of La Rochelle & MNHN Expected results (according to the Application Form) This phase allowed the laboratories of the different regions to pool their technological work and adapt them to the needs of industries: Availability of resources, raw materials, co-products; Extraction and identification process of natural substances, transformation process; Adaptation of processes to pilot scale, ; Functional foods ; web based traceability systems. Creation of a long-term network and elaboration of joint R&D activities and expertises between members of the network. Describe the way in which the action was implemented Transfer partners helped the laboratories to define the work to be done in order to adapt their research to the SMEs. They prepared questionnaire to laboratories, and analysis it, they prepared frameworks for leaflets especially focused on the research needs of SMEs. SME research needs were gleaned from questionnaire s, meetings and direct contact with relevant senior management within SME s. The laboratories worked in a complementary way in order to build a network with common research. This was done during Steering committee meetings, via s, phone calls and individual meetings. Partners involved in implementing the action Partner name Country Role in implementing the action Place(s) implemented All partners F, SP, Pt, UK Surveys Analysis of data and results of surveys Leaflets on laboratories fields of competences Technological developments Each partner Description of the results achieved Analysis of which results from laboratories and which technological services could be transferred to SMEs A questionnaire was elaborated by the transfer partners to help laboratories to focus VALBIOMAR activities in SMEs needs. The different following headings were asked to each laboratory: TYPES of RESULTS: results to be transferred, Market for the offering, Sort of companies to maker the offer. PRODUCTS: Raw materials, Compounds to be obtained, Use and application. TECHNOLOGICAL SERVICES: Description, Cost, Time of response.seminars. ON-LINE COURSES. Leaflets on the competences of each lab for SMEs The transfer partners prepare a frame to help the laboratories to present their activities to SMEs. Results: leaflets, One leaflet by laboratory (National language + EN). IPIMAR works to elaborate specific leaflets : Hidrolisados proteicos de pescado. Preparação, propriedades e utilizações. Publicações Avulsas do IPIMAR, 14, 32 p. A book to disseminate the preparation and properties of fish protein hydrolysates. Óleos de peixe: Importância para a saúde e preparação de concentrados de ácidos gordos ω3. A brochure on the importance of fish oils for human health and the preparation of ω3 PUFA concentrates. Hidrolisados proteicos de pescado. A brochure on the preparation and properties of fish protein hydrolysates. 12

13 INTERREG III B Atlantic Area VALBIOMAR Final Report. Building a network with common research and adapting the research to industries needs Analysis of the state of fisheries resources and by-products. VALBIOMAR partners: MNHN, UBO, IPIMAR Report on the characterisation of sardine oil recovered in a canning industry. Reports on alternative methods for the preparation of ω3 PUFA concentrates using urea complexation and sardine oil as raw material. Report on the separation of diacylglyceryl ethers present in residues from the squalene production from shark liver oil. VALBIOMAR partners: IPIMAR Development of a sustainable process for extracting lipids and peptides of interest from marine sources, Optimisation of membrane process for fractionation of lipid and peptides, Development of a semi-continuous methodology for quantifying lipid compounds into matrix VALBIOMAR partners: IFREMER Nantes and Univ. Nantes- GEPEA Comparative studies of proteolytic enzymes VALBIOMAR partners: UBO ANTIOX, IFREMER Nantes A complete pre-industrial scale platform for the continuous production of peptides hydrolysates with biological activities, by grouping resources of Valbiomar partner VALBIOMAR partners: UBS LETEE, Univ. Nantes GEPEA, UBO ANTiOX, Ifremer Nantes Analytical platform for biochemical characterization of raw material, hydrolysates, lipids, VALBIOMAR partners: Ifremer Development of fractionation process of marine peptides hydrolysates by a sequence of membrane separations (ultra- and nanofiltration) to improve biological activities level. VALBIOMAR partners: Univ. Nantes GEPEA, UBO ANTiOX Very High Pressure Reverse Osmosis (up to 120 bar) to treat salted effluents or biological solutions VALBIOMAR partners: Univ. Nantes GEPEA Biotransformation process: optimization of enzymatic hydrolysis, production of hydrolysates with antioxidant properties VALBIOMAR partners : UBO - Anti-Ox, UBS Developments of in vitro assays for the evaluation of hydrolysate antioxydant capacity Comparative study of proteolytic enzymes ; developpement of tests using cellular models - Fractionation and concentration of active ingredients using membranes VALBIOMAR partners : UBS LET2E & LBCM, Univ. Nantes GEPEA Report on sources and selection of raw material, définition of by-products available for upgrading VALBIOMAR partners : UBO-AntiOx, MNHN, IPIMAR Quantification of marine organic toxins using HPLC/MS Evaluation of active inhibitors of protein phosphatase PP2A VALBIOMAR partners : Univ La Laguna, IEO de Vigo-CSIC; Integrin Advanced Biosystems Ltd Identificación de nuevos principios activos a partir de extractos celulares Soria Natural Búsqueda biodirigida de nuevos metabolitos secundarios marinos con actividad citotoxica Biolab VALBIOMAR partners : Involved indutries: Instituto Canario de Investigación del Cancer 13

14 INTERREG III B Atlantic Area VALBIOMAR Final Report. Búsqueda bio-dirigida de nuevos metabolitos secundarios marinos con actividad citotoxica Biolab VALBIOMAR partners : Involved indutries: Instituto Canario de Investigación del Cancer Screening of aquaculture fouling species for anti-cancer and anti-microbial activity Valbiomar partner: Integrin Advanced Biosystems Ltd. Development of a web-based traceability system (Safe-C) suitable for use by SME s in the management of fisheries and aquaculture by-products Valbiomar partners: Integrin Advanced Biosystems Key dates of the action analysis of the questionnaires printing of the leaflets Justification of any discrepancies between the action as planned and as implemented, if any Achievements in conformity with the programme Total cost of the action (in Euros) including VAT : ,49 14

15 INTERREG III B Atlantic Area VALBIOMAR Final Report. ACTIONS CONDUCTED (Cf. Application Form point 3.7 and 3.5) Action NATURE OF THE ACTION 3 Information of SMEs on the advancement of work and possible adaptations Leader CETMAR Expected results (according to the Application Form) SMEs are not fully aware of the possibilities of the laboratories and of their results. Communication activities will thus raise up their interest and inform them about marine biotechnologies. Describe the way in which the action was implemented VALBIOMAR partners focused their actions on the organisation of specific technical seminars for SMEs (see below). Partners involved in implementing the action Partner name Country Role in implementing the action Place(s) implemented All partners F, SP, General leaflet for SMEs Each partner Pt, UK Website Virtual Learning Tool Surveys to SMEs Technical seminars and training sessions 15

16 INTERREG III B Atlantic Area VALBIOMAR Final Report. Description of the results achieved General leaflet Writting of the texts in FR and EN and building of the general leaflet of VALBIOMAR project addressed to companies. Leaflets explaining the competencies of the laboratories are put inside this general leaflet. Website Texts: Definition of the architecture of the website and Writting of the texts in FR, EN, SP, PT Electronic part: Definition of the electronic databases, Programming, maintenance of the website, Purchase and maintenance of domain name Graphics: Computer graphics also used for the valbiomar brand Registration of companies (120 people): Control and validation of the registered people Database of companies Building of the database of companies interested by VALBIOMAR laboratories competencies (in France: 800 companies, in UK: 400 companies, in SP: 1000 companies, in PT: 100 companies) in specific industries: Fishing industry; animal feed; pharmacological, cosmetic and biotechnological companies, technical centres, Sectorial/SMEs associations, Chambers of commerce, science parks, institutions, local authorities, consultants, etc. Elaboration of a training template to be used by the technological centers to present the offer to the SMEs Elaboration of questionnaires for the laboratories associates of VALBIOMAR to obtaining the results potentially transferable to the SMEs. For each template the information obtained was: Title of the training session; Description; Strategic interest; Target sector; Target audience; Facilities and equipment; Materials; Possibilities of a course in the e-learning tool; Duration; Participants max; Trainers Elaboration and organisation of training sessions and information seminars For each event : Definition of the frame, thematic, date, location, Programme, conferences/round table, timing, Rooms booking, restaurant, coffee breaks, Slides template, slides collecting, Creation of the invitation letter, printing and mailing, Mailing database of companies, Set up of the rooms, Creation and development of documents for participant: questionnaire, participants list and speakers details lists, slides booklet + nametags, Registration management, Press contacts, press conference, elaboration of the press kit, reception of journalists. The lists of these events are detailed in the key dates section. 16

17 INTERREG III B Atlantic Area VALBIOMAR Final Report. Surveys Surveys were done to SMEs in order to better know their needs. As e.g. report made by CETMAR of the current situation in Spain of the research in biotechnological exploitation of marine resources to assess the Spanish current situation on the research on marine resources. This report allowed the establishment of targets and objectives to be carried out along the project. The following information was obtained: Spanish research centers developing lines of investigation, analytical technologies and/or results of interest for VALBIOMAR project; patents of marine products and Spanish companies developing industrial activities related to the project. Approx. 350 questionnaires sent. In France a survey about effluents was made by UBS-LETEE, Technopole Qimper-Cornouaille. 88 Food companies. In Portugal, a questionnaire was sent to companies and research centres to identify the interest in the project and training. Approx. 160 questionnaires sending. Elaboration of a Virtual Learning Tool Supporting tool for the organization of on-line courses uploading of the documents and materials received (summaries and slides of lectures; exercises, etc...) The training courses and the documentation of all VALBIOMAR conferences and seminars are available in the site for the participants at the sessions and the users who are registered at the VALBIOMAR website. Lectures of the following training sessions: Membrane separation of marine molecules and substances ; Saint-Nazaire (France); June VLT: 49 users (French version) and 59 users (English version) Upgrading and exploitation of fish wastes and by-products ; Vigo (Spain) 5-6 May VLT: 255 users Ensilages and fish protein hydrolysates: description and properties, preparation and applications for the aquaculture ; Vigo (Spain) 17 November VLT: 196 users New bioactive molecules in marine hydrolysates ; Quimper (France) 4 November VLT: 100 users / Vigo (Spain) 5 May 2006.VLT:154 users Bioactive molecules from algae, marine invertebrates and microorganisms bioactive molecules in marine hydrolysates ;Vigo (Spain) October VLT: users 17

18 INTERREG III B Atlantic Area VALBIOMAR Final Report. Key dates of the action December 2004: Access to the Website, October 2005: Printing of the General leaflet Valbiomar, 1670 printings February 2005: Access to the VLT by the project partners (Access by the SMEs from May 2005) Specific information and training sessions: June 2004, St Nazaire: Technical session Membrane separation of marine molecules and substances 6 companies from cosmetics, ingredients, food VALBIOMAR partners co-managers: Uni Nantes, UBS, Technopole Quimper-Cornouaille 15 October 2004, Vannes: Presentation of the LBCM 11 companies from culture of algae, cosmetics, therapy, animal health, ingredients VALBIOMAR partners co-managers: UBS, Technopole Quimper-Cornouaille October 2004, Lisbon, Training session Fish hydrolysates and omega3 session 2 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 24 February 2005, Olhão, Seminar A tecnologia de produção de hidrolisados proteicos de pescado 3 companies from the canning, fish sector and fish administration VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 5-6 May 2005, Upgrading and exploitation of fish wastes and by-products VALBIOMAR partners co-managers: Integrin 5-6 May 2005, Vigo, Upgrading and exploitation of fish wastes and by-products - Seminar on fish wastes and byproducts generated from fishing activities, overview of alternatives of treatment and processing to obtain high value products. 75 participants : 51 participants from industrial sector (39 companies) and 24 participants of public organisms and laboratories); 15 lecturers. VALBIOMAR partners co-managers: CETMAR Other VALBIOMAR partners involved: IPIMAR 23rd June 2005, Lisbon, Training session Fish hydrolysates and omega3 session 2 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 28 September 2005, Introduction to Valbiomar project VALBIOMAR partners co-managers: Integrin Sept 2005, Shetland, Introduction of Valbiomar project to industry and researchers in Shetland 30 students, researchers and industry representatives VALBIOMAR partners co-managers: Integrin September 2005, Lisbon, Training session Preparation of fish hydrolysates 1 company VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 14 October 2005, Lisboa. VALBIOMAR Seminar Aproveitamento e Valorização de Resíduos e Subprodutos da Pesca. 20 companies from different fish sectors. VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 21 October 2005, Lisbon,, Valbiomar seminar, 80 participants, 3 enterprises VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 4 Novembre 2005, Quimper: Training session Enzyme hydrolysis 21 companies from ingredients, food, fishery, cosmetics, animal health, therapy VALBIOMAR partners co-managers: UBO (Anti ox), Technopole Quimper-Cornouaille Other partners MNHN, Univ. La Rochelle, Ifremer. SMEs: CTPP Boulogne, Diana Naturals 18

19 INTERREG III B Atlantic Area VALBIOMAR Final Report. 17 November 2005, Lessons from the East (Near and far): Furthering marine biotech in the UK and Ensilages and fish protein hydrolysates: properties, preparation and applications for the aquaculture 20 persons from SMEs and research institutes VALBIOMAR partners co-managers: Integrin 17 November 2005, Vigo, Ensilages and fish protein hydrolysates: properties, preparation and applications for the aquaculture - Theoretical session to provide an overview of the industrial possibilities of preparation and utilization of ensilages and fish protein hydrolyzates, especially in the application for the animal feed; and a practical session: Preparation of Fish protein hydrolyzates and Fish ensilages in laboratory. 21 participants : 13 participants from industrial sector (9 companies) and 8 participants of public organism and laboratories); 7 lecturers; 1 colloquium and a practical session. VALBIOMAR partners co-managers: CETMAR / Other VALBIOMAR partners involved: IPIMAR 16 February 2006, Lisbon, Training session Fish hydrolysates and omega3 session 1 company VALBIOMAR partners co-managers: IPIMAR, ALICONTROL April 2006, Glasgow, Utilising Waste: Adding Value to your business - One day conference looking at problems for the fishing and aquaculture industries, dealing with fish, shellfish and crustaceans. The conference had speakers from industry, regulators and industry support bodies and was timed to coincide with the International Fishing and Aquaculture exhibitions in Glasgow April participants VALBIOMAR partners co-managers: Integrin / Other VALBIOMAR partners involved: MNHN 5 May 2006, Vigo, Obtaining of new bioactive molecules from marine hydrolysates - Session that provide a view on the biotechnological processes and the obtaining of new molecules from marine protein hydrolysates, as well as the possibilities of application of these compounds in several industrial sectors. Colloquium: From de laboratory to industry, from experimentation to innovation. 57 participants : 14 participants from industrial sector (13 companies) and 43 participants of public organism and laboratories; 6 lecturers; 1 colloquium. VALBIOMAR partners co-managers: CETMAR and University of La Laguna Other VALBIOMAR partners involved: University of West Brittany; University of La Rochelle 18 May 2006, Utilising Waste: adding value to your business VALBIOMAR partners co-managers: Integrin 18 May 2006, Lisboa. II Jornadas Qualidade, Inovação e Segurança dos Produtos da Pesca. 30 companies from different fish sectors including processing and marketing. VALBIOMAR partners co-managers: IPIMAR l2 May 06 - Aislamiento y purificación del principio activo de extractos comercializados suministrados por una empresa del sector farmacéutico. Soria Natura - Colaboración con la empresa en la determinación de nuevos principios activos VALBIOMAR partners co-managers: Univ La Laguna 8 June 2006, Azores island, Training session Preparation of fish hydrolysates 4 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 9 June 2006, Ponta Delgada (Azores). Jornada Técnica Valorização dos Subprodutos da Pesca. 4 companies from the fish canning industry sector. VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 7 September 2006, Nantes: Training session Algae 24 companies from ingredients, food, fishery, cosmetics, animal health, therapy VALBIOMAR partners co-managers: Univ Nantes, Technopole Quimper-Cornouaille Other VALBIOMAR partners involved: University of South Brittany, IFREMER Nantes October 2006, Vigo, Bioactive molecules from algae, marine invertebrates and microorganisms - Session that provide a view on new molecules from marine microorganism, as well as the possibilities of application of these compounds in several industrial sectors. 51 participants (14 participants from industrial sector (12 companies) and 37 participants of public organism and laboratories; 13 lecturers; 1 colloquium. VALBIOMAR partners co-managers: CETMAR / Other VALBIOMAR partners involved: University of La Laguna (co-organizer); University of Nantes; Integrin Advanced Biosystems Ltd 19

20 INTERREG III B Atlantic Area VALBIOMAR Final Report. Justification of any discrepancies between the action as planned and as implemented, if any Achievements in conformity with the programme Total cost of the action (in Euros) including VAT : ,05 20

21 INTERREG III B Atlantic Area VALBIOMAR Final Report. ACTIONS CONDUCTED (Cf. Application Form point 3.7 and 3.5) Action NATURE OF THE ACTION 4 Cooperation between laboratories and SMEs and specific developments Leader : UBO Expected results (according to the Application Form) Cooperation between laboratories and SMEs and ensuring that the results already obtained will be effectively used by industry. Describe the way in which the action was implemented After presentations of the specific know-how of the labs to selected SMEs, trial developments have been carried out. In some instances postgraduates researchers have been involved in these projects Partners involved in implementing the action Partner name Country Role in implementing the action Place(s) implemented All partners F, SP, Transfer partners: first contacts with Each partner Pt, UK SMEs Laboratories: technical development Description of the results achieved A large series of cooperations with SMEs have been initiated during the course of VALBIOMAR project. Only some of them have agreed for being cited in this report. Examples of cooperations are listed below. Application of traceability for the mussel industry VALBIOMAR partners: Integrin Advanced Biosystems Ltd Industrial partners: Scottish Shellfish Marketing Group (west of Scotland); AM Seafoods (North England) Novel industrial applications of algal toxins VALBIOMAR partner: Integrin Advanced Biosystems Ltd Industrial partner: English SME (confidential) Biochemical characterisation of fish protein hydrolysates prepared from tuna by-products VALBIOMAR partner: IPIMAR Involved institute: INOVA (Azores) Extraction of fish oil from sardine by-products using different methods and characterisation of the oil recovered. VALBIOMAR partner: IPIMAR Involved industry: SARDINAL Preparation of 3 ethyl esters concentrates by urea complexation Separation of diacylglyceryl ethers from shark liver oil by-products VALBIOMAR partner: IPIMAR Involved industry: DEPSIEXTRACTA Demonstration session on the preparation of fish protein hydrolysates VALBIOMAR partner: IPIMAR and ALICONTROL Involved industry: SARDINAL Workshop on the preparation of fish protein hydrolysates VALBIOMAR partner: IPIMAR and ALICONTROL Involved institute: INOVA (Azores) 21

22 INTERREG III B Atlantic Area VALBIOMAR Final Report. Membrane fractionation of industrial hydrolysates containing biological activities VALBIOMAR partners : UBS-LETEE, Univ. Nantes-GEPEA Involved industries: DIANA Naturals-Berric-France, 1 SME in food & cosmetic industries (confidential) Clarification of a protein extract from microalgae VALBIOMAR partners : UBS-LETEE, Univ. Nantes-GEPEA Involved industries: Alpha Biotech Assérac France Réalisation d analyses : évaluation de l activité anti-oxydante d hydrolysats marins VALBIOMAR partners : UBO-AntiOx Involved industries: 3 companies (confidential) Collaboration with a private company including a phd grant VALBIOMAR partners : UBO-AntiOx, MNHN Involved industries: DIANA Naturals, Comapeche Saint Malo-Santé Processing and the recycling of fish brines collaboration with a SME (confidential). Discussion is currently in hand. VALBIOMAR partner: University of South Brittany-LETEE and University of Nantes-GEPEA. Industrial partner: SME (confidential) Search for peptides inhibiting ACE enzyme (anti-hypertensive) in marine by-products hydrolysates, Evaluation of the antiproliferative activity on cellular models of fish enzymatic hydrolysates VALBIOMAR partners: Univ. La Rochelle Involved industries: CTPP-Boulogne/mer-France Search in marine hydrolysates for peptides exhibiting calcitonine, CGRP or gastrine - CCK profiles by radioimmunoassay and radioreceptorassays ( CT and CGRP) by radiouimmunoassays (gastrin). Molecular sieving of the active molecules. Development of animal cultured cells to test the effect of hydrolysates on the production of gastrin/cck (bioassays) collaboration with a new research center for gastrin assays (university of Lille) VALBIOMAR partners: MNHN Concarneau Involved industries: Diana naturals-berric-france and Comapeche-Saint- Malo-France, 1 SME confidential Evaluation of the antiherpetic activity of substances extracted from marine microalgae and macroalgae and Development new biotests (cytotoxicity on new mammalian cell lines, antiviral model virus INPV and SHV) VALBIOMAR partners: UBS-LBCM Involved industries: Involved industries: Goémar, SOMAIG AFSSA-Plouzané-France Evaluation of antioxidant activity of marine hydrolysates VALBIOMAR partners : UBS LET2E, Univ. Nantes GEPEA Involved industries: Diana-Naturals-Berric-France Upgrading of by-products from a surimi plant VALBIOMAR partners : IFREMER Nantes Involved industries: 1 SME (confidential) Biochemical characterization of marine by-products (solid and liquid) from industrial plants VALBIOMAR partners: IFREMER Nantes Involved industries: 3 SME (confidential) 22

23 INTERREG III B Atlantic Area VALBIOMAR Final Report. Key dates of the action The cooperations here above were achieved from January 2005 to December Justification of any discrepancies between the action as planned and as implemented, if any Achievements in conformity with the programme Total cost of the action (in Euros) including VAT : ,25 23

24 INTERREG III B Atlantic Area VALBIOMAR Final Report. ACTIONS CONDUCTED (Cf. Application Form point 3.7 and 3.5) Action NATURE OF THE ACTION 5 Communication Leader : Technopole Quimper Cornouaille Expected results (according to the Application Form) To promote Atlantic regions as European Quality Centre (Labs and industries) in the different domains of biotechnological exploitation of marine resources. Describe the way in which the action was implemented All the partners worked for the local and international diffusion of VALBIOMAR activities. It was done through the website, local newspapers, specialised magazines, Press Conference, international conferences Partners involved in implementing the action Partner name Country Role in implementing the action Place(s) implemented All partners F, SP, Corporate image Each partner Pt, UK Site web Dissemination events Articles Description of the results achieved OBJECTIVES In the project work plan, a considerable effort was to be allocated to the dissemination of the results The consortium undertook the development and execution of the work plan to achieve successfu dissemination of the project results. The dissemination was to be performed at two levels: local level (in each region involved in the project) and European level. Results and data obtained during the project will be dispatched through severa procedures. 1 Dissemination of primary results : publication in international specialised journals and in professional technical magazines (Food, Animal feeds, Sea-Food, Health). 2 - Participation of the consortium to events to diffuse results of the project, meet industrialists, facilitate technology transfer and give information on the VALBIOMAR platform. All partners will identify at least two or three events per region where dissemination activities dealing with VALBIOMAR could be performed. 3 Permanent Web site with scientific and industrial exchanges and technological survey 4 Specialised seminars sorted by groups of activity and open meetings directed toward distinct categories of local economic and politic agents. In order to ensure the right results in the dissemination of results, a specific workpackage has been defined and one of the partners has been assigned for its leadership. RESULTS Dissemination plan and results This document is available. Corporate image Use of a common logo. A logo of VALBIOMAR exists in the language of each partner : SP, P, F, EN. Common invitation letter with the logo and pictures. Used as well for the website. Template for PPT. 24

25 INTERREG III B Atlantic Area VALBIOMAR Final Report. Dissemination events In addition to specific formation and demonstration activities (see activity 3), information on the project, partners and scientific offer was given in all the VALBIOMAR events organized during the project. - June 2004, University of Nantes, conference with an invited speaker (Prof C. Barthomeuf) on Antitumor from marine sources: structure and mechanism of action - Public: studends, academic and 2 SME (Atlanchim and Euroseafood traiding) Blue Biotech Meeting, Bremenhaven Integrin May 27, Ecoforum Poitiers, Y. Le Gal MNHN June 8, IMBC St Johns Canada, Invited keynote lecture Y. Le Gal MNHN October, Symposium Nutrition Santé Granville PPT presentation Y. le Gal - - Octobre 2005, Stalle à Granville Colloque Industries nutrition-santé, Ifremer, Technopole Quimper-Cornouaille, IFREMER Nantes - March 2006 FishUpdate: Utilising Waste: adding value to your business Integrin - April 2006 FishUpdate: Opportunity to discuss safety and traceability with Integrin april, Saint-Nazaire, Oral or poster presentations of the VALBIOMAR network in various events (Dynamique et représentation du littoral, RUOA,) or in different national/international Universities or Research centers (University of Rimouski and CRBM, Québec ; CZRI, Shippagan, Canada; ) - May 2006 Fish Farming International: Waste discussed and toxins tested by Integrin - July 2006 Fish Farming Today: Integrin s Answer to Legislation Innovation Integrin - April 2006 I2I Meeting, Iceland Integrin May 18, Fish Fair Glasgow May, Round table organised by Integrin, Presentation by Y. Le Gal MNHN - June 2006, Journées Aliments Santé, La Rochelle - Industries nutraceutique Conférences sur les enjeux et le potentiel des biotechnologies marines en France et en Europe - 1 entreprise du secteur pharmaceutique (mars 2006), centres techniques bretons (15 participants ; avril 2006), UBO-AntiOx September-Concarneau Invitation to local administrative and politcal staff. Press articles - October-November 2003, article Produits de la mer on Valbiomar project , La lettre de Nantes Métropole, «le programme Valbiomar Interreg III B» - Year 2004: Newspaper «la gazette du laboratoire» - Year 2004 : Newspaper on line : - July-Septembre 2004, Interface, article with Valbiomar mention - 16/10/2004, Ouest France, article on Valbiomar meeting with SMEs Vannes - 06/2004, 12/2005, 12/2004, Votre Technopole, 3 articles - Year 2005: Newspaper on-line: - Year 2005: (portal web); (aquaculture website); (aquaculture website); (Fishing website); La Voz de Galicia (Newspaper) - avril 2005, Sciences ouest n 209, dossier Europe Pages 14 et 15, Les faux poisons à l honneur : quand l Europe favorise la valorisation les co-produits de la pêche. - 05/11/2005, Ouest France, article on valbiomar Training session Hydrolysates Quimper: Utiliser 100% du poisson. - 11/11/2005, Le Progrès, article on valbiomar Training session Hydrolysates Quimper - 5 nov. 2005, Le télégramme, article on valbiomar Training session Hydrolysates Quimper p.16 : Ressources Marines : Valoriser 100% du poisson , Revue de Presse CCI Quimper : - Year 2006 : reference to Valbiomar project into a general article on marine products in RIA, april Year 2006: Official web of the Galicia government: Newspapers on-line: Aquaculture, fishing and I+D websites:

26 INTERREG III B Atlantic Area VALBIOMAR Final Report. - Avril 2006, RIA, Innovations, valorisation des coproduits et produits de la mer menés en France et en Europe - 30/06/06, Le progrès, article about Valbiomar and by-products - 08/09/2006, Ouest France - Loire-Atlantique, n page 15, Tout est bon dans le poisson, article on Valbiomar Training session Algae in Nantes - 09/09/2006, Presse Océan, n page 4, Les algues ont de l avenir, article on Valbiomar Training session Algae in Nantes - 19/09/2006, CCI Quimper Revue de presse, article on Valbiomar project - 19/09/2006, Ouest-France, article on Valbiomar project - 19/09/2006, Le Télégramme, article on Valbiomar project - 22/11/06, Les échos, Les biotechnologies misent sur les richesses de la mer, article de Cédric Duval. - 11/12/2006, Ouest France : Le prix de la recherche à Benoit Cudennec - Jan 2007, Sillage Le Magazine de la Ville de Concarneau, p 21 : Valbiomar, pour tirer le meilleur des ressources marines A public website This Internet platform helps research partners to get contacts and exchange information with the industrialists and SMEs. It supports SMEs and companies during the transfer technology process. The information platform is made up of three parts: a private part is accessible only by the project partners for collaborative work; a public part presents the project, the consortium and invites people interested in the subject to become member of the VALBIOMAR community. The registration to become member is free of charge and allows the consortium to get a panorama of the interested SMEs and companies; the VALBIOMAR community part allows registered people to access to more information about the subject (forums, exchanges, on-line directory ). VALBIOMAR project was advertised as well in the partners website. As example, IPIMAR made a public web subsite, linked to the website of the VALBIOMAR project was created where the objectives and the activities in the project were mentioned and the communications presented in the seminar and sessions for the fish processing industries were made available. Mailing Dissemination contacts Contacts with networks, Science parks, Technical centres, CRITT, Sectorial/SMEs associations, Chambres of commerce, Bretagne Environment plus Contacts with newspapers and specialised magazines for diffusion of the website and events Mailing to companies for events Mailing to officials with leaflets Contacts made with some European networks in marine biotechnology Scanbalt Marine biotechnology group European Functional Food Net BlueBioNet: presentation at meeting in Bremenhaven June 2005 Contacts in Ireland Presentation to I2I conference, Iceland April Comprehensive mid-term report April pages VALBIOMAR results synthesis : small synthesis report sent to politicians (PTT document available) Key dates of the action: See list of events above Justification of any discrepancies between the action as planned and as implemented, if any Achievements in conformity with the programme Total cost of the action (in Euros) including VAT : ,13 26

27 INTERREG III B Atlantic Area VALBIOMAR Final Report. INFORMATION AND COMMUNICATION (Cf. Application Form point 10 and 3.9) REMINDER OF THE COMMUNICATION PLAN (Objectives, review and results) This section corresponds exactly to Activity 5 Communication of the present report. OBJECTIVES In the project work plan, a considerable effort was to be allocated to the dissemination of the results. The consortium undertook the development and execution of the work plan to achieve successful dissemination of the project results. The dissemination was to be performed at two levels: local level (in each region involved in the project), and European level Results and data obtained during the project will be dispatched through several procedures. 1 Dissemination of primary results : publication in international specialised journals and in professional technical magazines (Food, Animal feeds, Sea-Food, Health). 2 - Participation of the consortium to events to diffuse results of the project, meet industrialists, facilitate technology transfer and give information on the VALBIOMAR platform. All partners will identify at least two or three events per region where dissemination activities dealing with VALBIOMAR could be performed. 3 Permanent Web site with scientific and industrial exchanges and technological survey 4 Specialised seminars sorted by groups of activity and open meetings directed toward distinct categories of local economic and politic agents. In order to ensure the right results in the dissemination of results, a specific workpackage has been defined and one of the partners has been assigned for its leadership. RESULTS Dissemination plan and results This document is available. Corporate image Use of a common logo. A logo of VALBIOMAR exists in the language of each partner : SP, P, F, EN. Common invitation letter with the logo and pictures. Used as well for the website. Template for PPT. Dissemination events In addition to specific formation and demonstration activities (see activity 3), information on the project, partners and scientific offer was given in all the VALBIOMAR events organized during the project. - June 2004, University of Nantes, conference with an invited speaker (Prof C. Barthomeuf) on Antitumor from marine sources: structure and mechanism of action - Public: studends, academic and 2 SME (Atlanchim and Euroseafood traiding) Blue Biotech Meeting, Bremenhaven Integrin May 27, Ecoforum Poitiers, Y. Le Gal MNHN June 8, IMBC St Johns Canada, Invited keynote lecture Y. Le Gal MNHN October, Symposium Nutrition Santé Granville PPT presentation Y. le Gal - - Octobre 2005, Stalle à Granville Colloque Industries nutrition-santé, Ifremer, Technopole Quimper-Cornouaille, IFREMER Nantes - March 2006 FishUpdate: Utilising Waste: adding value to your business Integrin - April 2006 FishUpdate: Opportunity to discuss safety and traceability with Integrin april, Saint-Nazaire, Oral or poster presentations of the VALBIOMAR network in various events (Dynamique et représentation du littoral, RUOA,) or in different national/international Universities or Research centers (University of Rimouski and CRBM, Québec ; CZRI, Shippagan, Canada; ) - May 2006 Fish Farming International: Waste discussed and toxins tested by Integrin - July 2006 Fish Farming Today: Integrin s Answer to Legislation Innovation Integrin - April 2006 I2I Meeting, Iceland Integrin May 18, Fish Fair Glasgow May, Round table organised by Integrin, Presentation by Y. Le Gal MNHN - June 2006, Journées Aliments Santé, La Rochelle - Industries nutraceutique Conférences sur les enjeux et le potentiel des biotechnologies marines en France et en Europe - 1 entreprise du secteur pharmaceutique (mars 2006), centres techniques bretons (15 participants ; avril 2006), UBO- AntiOx September-Concarneau Invitation to local administrative and politcal staff. Press articles - October-November 2003, article Produits de la mer on Valbiomar project , La lettre de Nantes Métropole, «le programme Valbiomar Interreg III B» - Year 2004: Newspaper «la gazette du laboratoire» - Year 2004 : Newspaper on line : 27

28 INTERREG III B Atlantic Area VALBIOMAR Final Report. - July-Septembre 2004, Interface, article with Valbiomar mention - 16/10/2004, Ouest France, article on Valbiomar meeting with SMEs Vannes - 06/2004, 12/2005, 12/2004, Votre Technopole, 3 articles - Year 2005: Newspaper on-line: - Year 2005: (portal web); (aquaculture website); (aquaculture website); (Fishing website); La Voz de Galicia (Newspaper) - avril 2005, Sciences ouest n 209, dossier Europe Pages 14 et 15, Les faux poisons à l honneur : quand l Europe favorise la valorisation les co-produits de la pêche. - 05/11/2005, Ouest France, article on valbiomar Training session Hydrolysates Quimper: Utiliser 100% du poisson. - 11/11/2005, Le Progrès, article on valbiomar Training session Hydrolysates Quimper - 5 nov. 2005, Le télégramme, article on valbiomar Training session Hydrolysates Quimper p.16 : Ressources Marines : Valoriser 100% du poisson , Revue de Presse CCI Quimper : - Year 2006 : reference to Valbiomar project into a general article on marine products in RIA, april Year 2006: Official web of the Galicia government: Newspapers on-line: Aquaculture, fishing and I+D websites: Avril 2006, RIA, Innovations, valorisation des coproduits et produits de la mer menés en France et en Europe - 30/06/06, Le progrès, article about Valbiomar and by-products - 08/09/2006, Ouest France - Loire-Atlantique, n page 15, Tout est bon dans le poisson, article on Valbiomar Training session Algae in Nantes - 09/09/2006, Presse Océan, n page 4, Les algues ont de l avenir, article on Valbiomar Training session Algae in Nantes - 19/09/2006, CCI Quimper Revue de presse, article on Valbiomar project - 19/09/2006, Ouest-France, article on Valbiomar project - 19/09/2006, Le Télégramme, article on Valbiomar project - 22/11/06, Les échos, Les biotechnologies misent sur les richesses de la mer, article de Cédric Duval. - 11/12/2006, Ouest France : Le prix de la recherche à Benoit Cudennec - Jan 2007, Sillage Le Magazine de la Ville de Concarneau, p 21 : Valbiomar, pour tirer le meilleur des ressources marines A public website This Internet platform helps research partners to get contacts and exchange information with the industrialists and SMEs. It supports SMEs and companies during the transfer technology process. The information platform is made up of three parts: a private part is accessible only by the project partners for collaborative work; a public part presents the project, the consortium and invites people interested in the subject to become member of the VALBIOMAR community. The registration to become member is free of charge and allows the consortium to get a panorama of the interested SMEs and companies; the VALBIOMAR community part allows registered people to access to more information about the subject (forums, exchanges, on-line directory ). VALBIOMAR project was advertised as well in the partners website. As example, IPIMAR made a public web subsite, linked to the website of the VALBIOMAR project was created where the objectives and the activities in the project were mentioned and the communications presented in the seminar and sessions for the fish processing industries were made available. Mailing Dissemination contacts Contacts with networks, Science parks, Technical centres, CRITT, Sectorial/SMEs associations, Chambres of commerce, Bretagne Environment plus Contacts with newspapers and specialised magazines for diffusion of the website and events Mailing to companies for events Mailing to officials with leaflets Contacts made with some European networks in marine biotechnology Scanbalt Marine biotechnology group European Functional Food Net BlueBioNet: presentation at meeting in Bremenhaven June 2005 Contacts in Ireland Presentation to I2I conference, Iceland April VALBIOMAR results synthesis Small synthesis report sent to politicians (in preparation). 28

29 INTERREG III B Atlantic Area VALBIOMAR Final Report. COMMUNICATION ACTIONS IMPLEMENTED Type of communication action conducted WEBSITE BROCHURES LEAFLETS BROCHURES BOOKS SCIENTIFIC JOURNALS Description Domain Compliance with publicity Yes standards (logo, EU flag...) (YES/NO) Date created December 2004 Languages (ENG, SP, FR, EN, SP, FR, PT PT) Intranet (YES/NO) YES Number of visits to date 11/06/06-11/12/06 (the only available figures): 1371 visitors, 9158 pages Ipimar: CETMAR: link to VALBIOMAR webpage Number of copies circulated 1670 * 1 brochure-folder Languages (ENG,SP,FR,PT) EN, SP, FR, PT Compliance with publicity YES standards (logo, EU flag...) (YES/NO) Downloadable (YES/NO) YES Date published October 2005 Number of copies circulated 670 * 8 different leaflets CETMAR: 200*8 different leaflets Languages (ENG, SP, FR, EN, SP, FR, PT PT) Compliance with publicity YES standards (logo, EU flag...) (YES/NO) Downloadable (YES/NO) YES Date published October 2005 Number of copies circulated 200 units Two brochures were prepared: Hidrolisados proteicos de pescado and Óleos de peixe: importância para a saúde e preparação de concentrados de ácidos gordos 3 by IPIMAR Languages (ENG,SP,FR,PT) EN, SP, FR, PT Compliance with publicity YES standards (logo, EU flag...) (YES/NO) Downloadable (YES/NO) NO Date published Both issued in October 2005 Number of copies circulated 1000 units Languages (ENG, SP, FR, PT PT) Compliance with publicity Yes standards (logo, EU flag...) Downloadable (YES/NO) No Date published October 2006 Name and number of the See list Annex 1 issue (date) Article title Number of pages Total cost of the action in Euros including VAT (TQC) 1.825,88 (Cetmar) See Ipimar (Action 5 total cost of the action) See Ipimar (Action 5 total cost of the action) 29

30 INTERREG III B Atlantic Area VALBIOMAR Final Report. PRESS ARTICLES Name of paper and article Date Languages FR, ES Downloadable (YES/NO) NO - October-November 2003, article Produits de la mer on Valbiomar project , La lettre de Nantes Métropole, «le programme Valbiomar Interreg III B» - Year 2004: Newspaper «la gazette du laboratoire» - Year 2004 : Newspaper on line : - July-Septembre 2004, Interface, article with Valbiomar mention - 16/10/2004, Ouest France, article on Valbiomar meeting with SMEs Vannes - 06/2004, 12/2005, 12/2004, Votre Technopole, 3 articles - Year 2005: Newspaper on-line: - Year 2005: (portal web); (aquaculture website); (aquaculture website); (Fishing website); La Voz de Galicia (Newspaper) - avril 2005, Sciences ouest n 209, dossier Europe Pages 14 et 15, Les faux poisons à l honneur : quand l Europe favorise la valorisation les co-produits de la pêche. - 05/11/2005, Ouest France, article on valbiomar Training session Hydrolysates Quimper: Utiliser 100% du poisson. - 11/11/2005, Le Progrès, article on valbiomar Training session Hydrolysates Quimper - 5 nov. 2005, Le télégramme, article on valbiomar Training session Hydrolysates Quimper p.16 : Ressources Marines : Valoriser 100% du poisson , Revue de Presse CCI Quimper : - Year 2006 : reference to Valbiomar project into a general article on marine products in RIA, april Year 2006: Official web of the Galicia government: Newspapers on-line: Aquaculture, fishing and I+D websites: Avril 2006, RIA, Innovations, valorisation des coproduits et produits de la mer menés en France et en Europe - 30/06/06, Le progrès, article about Valbiomar and byproducts - 08/09/2006, Ouest France - Loire-Atlantique, n page 15, Tout est bon dans le poisson, article on Valbiomar Training session Algae in Nantes - 09/09/2006, Presse Océan, n page 4, Les algues ont de l avenir, article on Valbiomar Training session Algae in Nantes - 19/09/2006, CCI Quimper Revue de presse, article on Valbiomar project - 19/09/2006, Ouest-France, article on Valbiomar project - 19/09/2006, Le Télégramme, article on Valbiomar project - 22/11/06, Les échos, Les biotechnologies misent sur les richesses de la mer, article de Cédric Duval. - 11/12/2006, Ouest France : Le prix de la recherche à Benoit Cudennec - Jan 2007, Sillage Le Magazine de la Ville de Concarneau, p 21 : Valbiomar, pour tirer le meilleur des ressources marines 30

31 INTERREG III B Atlantic Area VALBIOMAR Final Report. COMMUNICATION ACTIONS IMPLEMENTED (cont d) Type of communication action conducted MAJOR EVENTS in which the project took part Seminar name Date and venue Number of participants Type of audience: scientific, technical people, SMEs Mean audience: 50 to 300 Description Total cost (n.a) - June 2004, University of Nantes, conference with an invited speaker (Prof C. Barthomeuf) on Antitumor from marine sources: structure and mechanism of action - Public: studends, academic and 2 SME (Atlanchim and Euroseafood traiding) Blue Biotech Meeting, Bremenhaven Integrin May 27, Ecoforum Poitiers, Y. Le Gal MNHN June 8, IMBC St Johns Canada, Invited keynote lecture Y. Le Gal MNHN October, Symposium Nutrition Santé Granville PPT presentation Y. le Gal - - Octobre 2005, Stalle à Granville Colloque Industries nutritionsanté, Ifremer, Technopole Quimper-Cornouaille, IFREMER Nantes - March 2006 FishUpdate: Utilising Waste: adding value to your business Integrin - April 2006 FishUpdate: Opportunity to discuss safety and traceability with Integrin april, Saint-Nazaire, Oral or poster presentations of the VALBIOMAR network in various events (Dynamique et représentation du littoral, RUOA,) or in different national/international Universities or Research centers (University of Rimouski and CRBM, Québec ; CZRI, Shippagan, Canada; ) May 2006 Fish Farming International: Waste discussed and toxins tested by Integrin July 2006 Fish Farming Today: Integrin s Answer to Legislation Innovation Integrin - April 2006 I2I Meeting, Iceland Integrin May 18, Fish Fair Glasgow May, Round table organised by Integrin, Presentation by Y. Le Gal MNHN June 2006, Lisboa (Portugal) III Congresso de Análises Clínicas e Saúde Pública - June 2006, Journées Aliments Santé, La Rochelle - Industries nutraceutique Conférences sur les enjeux et le potentiel des biotechnologies marines en France et en Europe - 1 entreprise du secteur pharmaceutique (mars 2006), centres techniques bretons (15 participants ; avril 2006), UBO-AntiOx 31

32 INTERREG III B Atlantic Area VALBIOMAR Final Report. WORKSHOPS Workshops organised by the project CONFERENCES AND TRAINING SESSIONS Workshop name Date and venue Number of participants Type of audience Seminar name June 2004, St Nazaire: Technical session Membrane separation of marine molecules and substances 6 companies from cosmetics, ingredients, food VALBIOMAR partners co-managers: Uni Nantes, UBS, Technopole Quimper- Cornouaille 15 October 2004, Vannes: Presentation of the LBCM 11 companies from culture of algae, cosmetics, therapy, animal health, ingredients VALBIOMAR partners co-managers: UBS, Technopole Quimper-Cornouaille October 2004, LOCATION, Training session Fish hydrolysates and omega3 session 2 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 24 February 2005, Olhão, Seminar A tecnologia de produção de hidrolisados proteicos de pescado panies from the canning, fish sector and fish administration BIOMAR partners co-managers: IPIMAR, ALICONTROL 5-6 May 2005, Vigo Upgrading and exploitation of fish wastes and by-products - Seminar on fish wastes and by-products generated from fishing activities, overview of alternatives of treatment and processing to obtain high value products. 75 participants (51 participants from industrial sector (39 enterprises) and 24 participants of public organisms and laboratories); 15 lecturers. VALBIOMAR partners co-managers: CETMAR Other VALBIOMAR partners involved: IPIMAR 5-6 May 2005, Vigo Ensilages and fish protein hydrolysates: properties, preparation and applications for the aquaculture - Theoretical session to provide an overview of the industrial possibilities of preparation and utilization of ensilages and fish protein hydrolyzates, especially in the application for the animal feed; and a practical session: Preparation of Fish protein hydrolyzates and Fish ensilages in laboratory. 21 participants (13 participants from industrial sector (9 enterprises) and 8 participants of public organism and laboratories); 7 lecturers; 1 colloquium and a practical session. VALBIOMAR partners co-managers: CETMAR Other VALBIOMAR partners involved: IPIMAR 23rd June 2005, LOCATION, Training session Fish hydrolysates and omega3 session 2 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 28 September 2005, Introduction to Valbiomar project VALBIOMAR partners co-managers: Integrin Sept 2005, Shetland, Introduction of Valbiomar project to industry and researchers in Shetland 30 students, researchers and industry representatives VALBIOMAR partners co-managers: Integrin September 2005, Lisbon, Training session Preparation of fish hydrolysates 1 company VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 14 October 2005, Lisboa. VALBIOMAR Seminar Aproveitamento e Valorização de Resíduos e Subprodutos da Pesca. 20 companies from different fish sectors. VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 21 October 2005, Lisbon,, Valbiomar seminar, 80 participants, 3 enterprises VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 32

33 INTERREG III B Atlantic Area VALBIOMAR Final Report. WORKSHOPS CONFERENCES AND TRAINING SESSIONS Workshop name Date and venue Number of participants Type of audience Seminar name 4 Novembre 2005, Quimper: Training session Enzyme hydrolysis 21 companies from ingredients, food, fishery, cosmetics, animal health, therapy VALBIOMAR partners co-managers: UBO (Anti ox), Technopole Quimper- Cornouaille Other partners MNHN, Univ. La Rochelle, Ifremer. SMEs: CTPP Boulogne, Diana Naturals 17 November 2005, Lessons from the East (Near and far): Furthering marine biotech in the UK and Ensilages and fish protein hydrolysates: properties, preparation and applications for the aquaculture 20 persons from SMEs and research institutes VALBIOMAR partners co-managers: CETMAR 16 February 2006, LOCATION, Training session Fish hydrolysates and omega3 session 1 company VALBIOMAR partners co-managers: IPIMAR, ALICONTROL April 2006, Surveys Mailing effluents 88 Food companies VALBIOMAR partners: UBS-LETEE, Technopole Quimper-Cornouaille April 2006, Glasgow, Utilising Waste: Adding Value to your business - One day conference looking at problems for the fishing and aquaculture industries, dealing with fish, shellfish and crustaceans. The conference had speakers from industry, regulators and industry support bodies and was timed to coincide with the International Fishing and Aquaculture exhibitions in Glasgow April participants VALBIOMAR partners co-managers: Integrin Other VALBIOMAR partners involved: MNHN 5 May 2006, Vigo Obtaining of new bioactive molecules from marine hydrolysates - Session that provide a view on the biotechnological processes and the obtaining of new molecules from marine protein hydrolysates, as well as the possibilities of application of these compounds in several industrial sectors. Colloquium: From de laboratory to industry, from experimentation to innovation. 57 participants (14 participants from industrial sector (13 enterprises) and 43 participants of public organism and laboratories); 6 lecturers; 1 colloquium. VALBIOMAR partners co-managers: CETMAR and University of La Laguna Other VALBIOMAR partners involved: University of West Brittany; University of La Rochelle 18 May 2006, Utilising Waste: adding value to your business VALBIOMAR partners co-managers: Integrin 18 May 2006, Lisboa. II Jornadas Qualidade, Inovação e Segurança dos Produtos da Pesca. 30 companies from different fish sectors including processing and marketing. VALBIOMAR partners co-managers: IPIMAR l2 May 06 - Aislamiento y purificación del principio activo de extractos comercializados suministrados por una empresa del sector farmacéutico. Soria Natura - Colaboración con la empresa en la determinación de nuevos principios activos VALBIOMAR partners co-managers: Univ La Laguna 8 June 2006, Azores island, Training session Preparation of fish hydrolysates 4 companies VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 9 June 2006, Ponta Delgada (Azores). Jornada Técnica Valorização dos Subprodutos da Pesca. 4 companies from the fish canning industry sector. VALBIOMAR partners co-managers: IPIMAR, ALICONTROL 33

34 INTERREG III B Atlantic Area VALBIOMAR Final Report. WORKSHOPS CONFERENCES AND TRAINING SESSIONS Workshop name Date and venue Number of participants Type of audience Seminar name 7 September 2006, Nantes: Training session Algae 24 companies from ingredients, food, fishery, cosmetics, animal health, therapy VALBIOMAR partners co-managers: Univ Nantes, Technopole Quimper- Cornouaille Other VALBIOMAR partners involved: University of South Brittany, IFREMER Nantes October, 2006 Bioactive molecules from algae, marine invertebrates and microorganisms - Session that provide a view on new molecules from marine microorganism, as well as the possibilities of application of these compounds in several industrial sectors. 51 participants VALBIOMAR partners co-managers: CETMAR Other VALBIOMAR partners involved: University of La Laguna (coorganizer); University of Nantes; Integrin Advanced Biosystems Ltd 21 December 2006, Workshop Genetic traceability of seafood 13 companies from fishery, food, ingredients VALBIOMAR partners co-managers: MNHN, Technopole Quimper- Cornouaille Workshop name Dissemination to Brittany local administrative and political people Date and venue 18 September 2006 Concarneau (FR) Number of 10 persons participants Type of audience Brittany local administrative and political people DISSEMINATION Documentation No organised by the available project (YES/NO) downloadable? CD title Date and venue CD Number of copies circulated Number of participants Languages Video/DVD title Seminar name VIDEO/DVD Number of copies circulated Date and venue Languages Event (venue/date) Technopole General Assembly Quimperlé 4 June 2004 Cost (TQC) : 34,01 POSTERS Languages FR Event (venue/date) Technopole General Assembly Quimper 13 May 2005 Cost (TQC) : 37,73 Languages FR Event (venue/date) Granville Symposium Santé-Mer Granville 6-7 October 2005 Cost (TQC) : 23,47 Languages FR/EN Event (venue/date) Workshop Traceability Concarneau 21 December 2006 Cost (TQC) : 452,09 Languages FR Event 7º Encontro de Química dos Alimentos: Tradição e Inovação, Saúde e Segurança, Viseu (Portugal) April 2005 Cost : Language EN Radio Radio Intereconomia (on-line radio station: Radio Programmes Programme: Capital mediodia Date 28 august 2006 at 12:00 AM Language SP (CETMAR) Radio station/programme 1 radio interview Date 2 October 2006 at 6:00, 7:00, 8:00 and 9:00 Languages FR PLEASE ATTACH A COPY OF ANY PUBLICITY OR INFORMATION DOCUMENTS PRODUCED WITHIN THE FRAMEWORK OF THE PROJECT 34

35 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEX I Scientific papers relative to VALBIOMAR Project (International specialized journals and books, proceedings) Oral Communications, posters. Specialized seminars, workshops. - Fractionnement et concentration d hydrolysats de collagène de poisson par procédés à membranes, Vandanjon L., Chabeaud A., Guerard F., Jaouen P., Delannoy C., Bourseau P., Mempro 3, Intégration des membranes dans les procédés, avril 2006, Nancy, France - Dimensionnement et estimation du coût d un procédé intégré de fractionnement et de dessalement d une solution de peptides biologiquement actifs, Bourseau P., Vandanjon L., Jaouen P., Chabeaud A., F. Guerard. Mempro 3, Intégration des membranes dans les procédés, avril 2006, Nancy, France. - La recherche de substances antioxydantes à partir de produits marins, Guerard F. UNIVERSITE DE PRINTEMPS "Dynamiques et représentations du littoral", avril 2006, Saint-Nazaire, France. Recherche de substances anticancéreuses dans l'environnement marin, L. Process Engineering for adding value to marine substances, Picot, JM. Piot, Réseau Universitaire Ouest Atlantique, Ecole de Printemps «Dynamiques et représentations du littoral»,(west Atlantic University Network, Spring School Littoral Dynamics and Representations), avril 2006, Saint-Nazaire, France - Procédés enzymatiques pour le fractionnement et l enrichissement (peptides marins). Guerard F. Forum «Ingrédients naturels en santé-bien-être. Innovations dans les procédés d obtention et de mise en œuvre des ingrédients», 7-8 décembre 2006, Vannes, France. Communication orale, sur invitation. Mise au point d un procédé innovant pour la production de bio-ingrédients marins dotés de propriétés antioxydantes. D. Laroque, B. Linard, C. Berger, E. Vouland & F. Guérard. Forum INGREDIENTS NATURELS en SANTE-BIEN-ETRE, 7-8 décembre 2006, Vannes, affiche. - Valorisation des coproduits de Lieu noir (Pollachius virens) :Production d un hydrolysat enrichi en activités antioxydantes. A. Chabeaud, F. Guérard, P. Dutournié, L. Vandanjon, P. Bourseau, C. Chopin, J.P. Bergé. Forum INGREDIENTS NATURELS en SANTE-BIEN-ETRE, 7-8 décembre 2006, Vannes, affiche. - Concentration and deodorization of white fish peptides using ultrafiltration and nanofiltration. Vandanjon L., Chabeaud A., Guerard F., Jaouen P., Bourseau P., TAFT meeting, Quebec, Canada, 29-octobre-2novembre 2006, affiche. Prix du meilleur poster - Towards the development of marine bio-ingredients with antioxidant properties: a case study. Guerard F., Chabeaud A., Laroque D., Denes A., Vandanjon L., Bourseau P., Jaouen P., Thorkelsson G. TAFT meeting, Quebec, Canada, 29-octobre-2novembre Communication orale. - Production of antioxidant peptides from Saithe (Pollachius virens) hydrolysate : study of hydrolysis parameters using response surface methodology. Chabeaud A., Guérard F., Dutournie P., Vandanjon L., Bourseau P. TAFT meeting, Quebec, Canada, 29-octobre-2novembre 2006, Communication orale. Molécules dotées de propriétés antioxydantes (polyphénols, peptides, caroténoïdes ) : entre marketing effréné et nécessaires études scientifiques démontrant ces activités. Dufossé L. & Guérard F.. 3ème Rencontre Entreprises-Recherche «Polyphénols : Sources, Activités, Analyses et Intérêts, 1er juin 2006, Angers, France. Communication orale. - Enzymatic hydrolysis of Saithe (Pollachius virens) proteins using Esperase : production of FPH exhibiting antioxidant properties, Laroque D., Denes A. & Guérard F. Symposium Européen Les Enzymes en Alimentaire/ Enzymes For Food EFF2006, Rennes, France, mai 2006, affiche. - Optimisation of the Antioxidant Activity of Saithe (Pollachius virens) Hydrolysate Using Response Surface Methodology, A. Chabeaud, P. Dutournié, F. Guérard, L. Vandanjon, P. Bourseau. Symposium Européen Les enzymes en alimentaire/ Enzymes For Food EFF2006, Rennes, France, mai 2006, affiche. - La recherche de substances antioxydantes à partir de produits marins, Guerard F. UNIVERSITE DE PRINTEMPS "Dynamiques et représentations du littoral", avril 2006, Saint-Nazaire, communication orale. - Les organismes marins comme sources de molécules d intérêt et d activité biologique. Barnathan G. RUOA Université de printemps, "Dynamiques et représentations du littoral", Nantes, 28 avril 2006, com. orale. - Antioxidant and free radical scavenging activities of marennine, a blue-green pigment from the diatom Haslea ostraeria responsible for natural greening of cultured oysters, Pouvreau J.B., Pondaven P., Morançais M., Fleurence J., Guérard F., Dufosse L. 4th International Congress on Pigments in Food, 9-12 octobre 2006, Stuttgart, Allemagne, affiche. Prix du meilleur poster -Processing of marine waste: production of hydrolysates harbouring specific biological properties. LeGal Y., Guérard F., Fouchereau-Péron M., Fruitier I., Bordenave S., Sannier F., Piot JM.. Conference IMBC 2005, 7-12 juin, St John s, Terre-Neuve, communication orale. 35

36 INTERREG III B Atlantic Area VALBIOMAR Final Report. - Optimization of the hydrolysis process of blue whiting (Micromesistius poutassou) co-products, for the generation of gastrin / cholecystokinin and CGRP related peptides Cudennec B, Ravallec-Plé R, Latimier M, Aubertin S, Guillochon D, Fouchereau-Peron M. TAFT 2006 Quebec October 2006(poster) - Presence of CGRP related molecules in fish protein hydrolysates from industrial origin Martinez-Alvarez O., Ravallec-Plé R., Delannoy C., Vercaigne-Marko D., Guillochon D. and Fouchereau-Peron M TAFT 2006 Quebec October 2006(poster) - Optimization of the hydrolysis process of blue whiting (Micromesistius poutassou) co-products, for the generation of gastrin / cholecystokinin and CGRP related peptides.cudennec B, Ravallec-Plé R, Latimier M, Aubertin S, Guillochon D, Fouchereau-Peron M. Forum Ingrédients Santé Bien Etre 7/8 septembre 2006 Vannes. Prix du meilleur poster - The French network SEA pro : a solution to a better fish wastes management? J.P Bergé, G. Barnathan, A. Bedouin, N. Bourgougnon, P. Bourseau, J. Fleurence, Y. Fleury, F. Guerard, P. Jaouen, M. Mireaux, L. Picot, C. Prost, R. Ravallec-Plé. Second Join Trans Atlantic Fisheries Technology Conference, Québec (Canada). - L'huile de poisson (hp) dissocie la phosphorylation d'akt de l'activité; phosphatidyl-inositol 3-kinase (pi3k) chez le rat. C. Le Foll, C. Corporeau, V. Leguen, J.P.Gouygou, J.P.Bergé, J. Delarue 6 èmes journées francophones de la nutrition, Nice.- A new mild procedure to get quantitative lipidic and peptidic fractions from sardine (Sardina pilchardus) heads, JAFT 2006, 2 nd Joint Atlantic Fisheries Technology Conference QUEBEC city, Oct. 29 Nov. 2 nd Séparation sur membranes de produits et de substances d origine marine,p. Bourseau P. Jaouen, L. Vandanjon. Club Français des Membranes, Journée thématique «Membranes et développement durable» (Membrane separation of marine products and substances, French Club on Membrane Technologies, Conference on Sustainable Development), Angers, 29 mars 2006, France. - Génie des procédés et valorisation des substances marines, P. Bourseau, P. Jaouen, L. Vandanjon., Réseau Universitaire Ouest Atlantique, Ecole de Printemps «Dynamiques et représentations du littoral», (Process Engineering for adding value to marine substances, West Atlantic University Network, Spring School Littoral Dynamics and Representations), avril 2006, Saint-Nazaire, France - Extraction de lipides en voie aqueuse par bioréacteur enzymatique combiné à l ultrafiltration: application à la valorisation de co-produits poisson. J. Dumay, G. Barnathan, P. Jaouen, Jp. Bergé : 31 ème Congrès de l Union des Océanographes de France, NANTES, France, 2-3 Novembre «Concentration de la marennine extracellulaire (EMn) produit par la diatomée Haslea ostrearia (Gaillon/ Bory) Simonsen par des procédés à membranes», M Morancais, Jb Pouvreau, M. Chaplain Derouiniot, P. Jaouen, P. Pondaven Université de printemps du RUOA (Réseau des Universités de l Ouest Atlantique) Dynamiques et représentations du Littoral, Avril 2006, SAINT-NAZAIRE - "Isolation and characterization of lipids and lipophilic substances of interest in the field of health, nutrition, aquaculture and cosmetics, from a marine biomass". Lecture by G. Barnathan: IV Seminario Valbiomar,Vigo, Spain, Centre Tecnologico del Mar, CETMAR, octobre 2006: "Moléculas de interés a partir de algas, invertebrados, microorganismos marinos" - Procédés enzymatiques pour le fractionnement et l enrichissement (peptides marins). Guerard F. Forum «Ingrédients naturels en santé-bien-être. Innovations dans les procédés d obtention et de mise en œuvre des ingrédients», 7-8 décembre 2006, Vannes, France. Oral communication. - Valorisation des co-produits de la pêche : enjeux et stratégies. Guerard F. & Robin M. Assemblée générale de la Technopole de Quimper-Cornouaille. 19 mai 2006, Le Guilivinec, France. Oral communication. - Production d hydrolysats enzymatiques dotés de propriétés antioxydantes. Guérard F. & Laroque D., Session de formation «Obtencion de nuevas moléculas bioactivas a partir de hidrolizados marinos», Programme européen VALBIOMAR «valorisation biotechnologique des ressources marines», 5 mai 2006, Vigo, Espagne. Oral communication. - «Ultrafiltration pour la purification de molécules algales», P. Jaouen Journée Formation biotechnologique : «Les algues, sources de molécules d intérêt : les lipides, les protéines, leurs méthodes d obtention et de caractérisation». Valbiomar Programme européen Espace atlantique Interreg IIIB, NANTES, 7 septembre même session : conférence de J. Fleurence - même session. conférence de G. Barnathan Substances marines lipidiques et lipophiles d intérêt en santé, nutrition, aquaculture et cosmétologie. "Lipophilic substances of interest from the sea" Lecture by G. Barnathan: Réunion de l Association Cosmétiques-Méditerranée. Ières Rencontres Scientifiques COSMED-Ouest, Nantes, Faculté de Pharmacie, 26 octobre The nature and the aims of the Valbiomar network were given and explained. 36

37 INTERREG III B Atlantic Area VALBIOMAR Final Report. "Known sources and alternative sources of DHA for human nutrition", Lecture by G. Barnathan: Journée annuelle du Groupe Lipides et Nutrition, Faculté de Médecine, Paris, 7 novembre 2006 sur : "DHA (docosahexaenoic), a major brain omega-3 fatty acid : until now and for the future". The nature and the aims of the Valbiomar network were given and explained. Paper to be published in 2007 in the Journal "Oléagineux, Corps gras, Lipides", John Libbey Eurotext Ed «Procédés de séparation par membranes appliqués aux produits de la mer et aux substances d'origine marine», P. Jaouen, P. Bourseau, Jp Berge, R Ben Amar, L Vanndanjon et al. Proc. Conférence Invitée UNESCO, (8 pages) Sciences et Technologies à membranes, Monastir Tunisie septembre New active compounds resulting from the glycation of shrimp hydrolysates. Guerard F., Sumaya-Martinez M- T., International Marine Biotechnology Conference IMBC. June 7-12, St John s, Newfoundland, CANADA, affiche. Search for biological activities in fish hydrolysates: Exciting preliminary results for nutraceutical applications Rozenn Ravallec-Plé, Yves Legal and Martine Fouchereau-Peron,Conference Granville october 2005 oral communication What could be the benefit of using enzymes for extracting lipids from fatty fish by-products? J. Dumay, A. Lheriau, G. Barnathan, P. Jaouen, J.P.Bergé. 35 th West European Fish Technologists Association Meeting. Anwerp, Belgium. Les enzymes protéases - utilisées pour la solubilisation des co-produits et la préparation de composés actifs. Guérard F. Séminaire «Nouveaux actifs marins : hydrolyser pour mieux valoriser!. Programme européen VALBIOMAR «valorisation biotechnologique des ressources marines», 4 novembre 2005, Quimper, France. Oral communication. - Hydrolysats marins et activités antioxydantes et antiradicalaires. Laroque D. & Guérard F. Séminaire «Nouveaux actifs marins : hydrolyser pour mieux valoriser!. Programme européen VALBIOMAR «valorisation biotechnologique des ressources marines», 4 novembre 2005, Quimper, France. Oral communication. Biological activities in fish and invertebrate hydrolysates Fouchereau-Peron M Marine Biotechnologies Workshop Brest avril 2005 sur invitation Search for biological activities in fish hydrolysates: Exciting preliminary results for nutraceutical applications Rozenn Ravallec-Plé, Yves Legal and Martine Fouchereau-Peron,Conference Granville october 2005 oral communication Enhancement of the radical scavenging activity of tuna waste hydrolysate. Guerard F., Sumaya-Martinez M-T., Thomas S., Linard B., Binet A. In: Total Food. Exploiting co-products minimizing waste, K. Waldron, C. Faulds & A. Smith Eds, ISBN Actes du colloque Européen Total Food, Exploiting coproducts minimizing waste, avril 2004, Norwich, Royaume-Uni, pp Recent developments of marine processing waste up-grading: production of hydrolysates with biological properties. Guérard F., Sumaya-Martinez M-T., Fouchereau-Péron M., Gildberg A., Stenberg E., Fruitier I., Bordenave S., Sannier F., Piot J-M., Bergé J-P. & Le Gal Y. In: Total Food. Exploiting co-products minimizing waste, K. Waldron, C. Faulds & A. Smith Eds, ISBN Actes du colloque Européen Total Food, Exploiting co-products minimizing waste, avril 2004, Norwich, Royaume-Uni, pp Fractionation and partial characterisation of antioxidant substances in Shrimp waste hydrolysate odified by Ribose. Sumaya-Martinez M.T., Linard B., Binet A., Guerard F. In: Total Food. Exploiting co-products minimizing waste, K. Waldron, C. Faulds & A. Smith Eds, ISBN Actes du colloque Européen Total Food, Exploiting co-products minimizing waste, avril 2004, Norwich, Royaume-Uni, pp Biotechnological upgrading of marine by-products: Production of enzymatic hydrolysates with antioxidant properties. Guerard F. & Sumaya-Martinez M.T, Linard B, Binet A. 3rd European symposium on cosmetic ingredients & biotechnology : 30 juin - 2 juillet 2004, Saint Malo, France, pp 23-33, sur invitation Biotechnological upgrading of marine by-products: Production of enzymatic hydrolysates with antioxidant properties. Guerard F. & Sumaya-Martinez M.-T. Colloque international COSM ING 2004, 30 juin-2 juillet 2004, St Malo, communication orale, sur invitation. - Effect of Maillard reaction conditions on the increase in free radical scavenging activity of browning products obtained from tuna waste hydrolysate. Sumaya-Martinez M.T., Guerard F., Thomas S., Linard B., Binet A. Congrès International "Pigments in Food", Juin 2004, Quimper, affiche. 37

38 INTERREG III B Atlantic Area VALBIOMAR Final Report. - Enhancement of the radical scavenging activity of tuna waste hydrolysate. Guerard F., Sumaya-Martinez M-T., Thomas S., Linard B., Binet A.. Colloque européen Total Food, Exploiting co-products minimizing waste, avril 2004, Norwich, Royaume-Uni, affiche. - Recent developments of marine processing waste up-grading: production of hydrolysates with biological properties. Guérard F., Sumaya-Martinez M-T., Fouchereau-Péron M., Gildberg A., Stenberg E., Fruitier I., Bordenave S., Sannier F., Piot J-M., Bergé J-P. & Le Gal Y. Colloque européen Total Food, Exploiting coproducts minimizing waste, avril 2004, Norwich, Royaume-Uni, affiche. - Fractionation and partial characterisation of antioxidant substances in Shrimp waste hydrolysate modified by Ribose. Sumaya-Martinez M.T., Linard B., Binet A., Guerard F.. Colloque européen Total Food, Exploiting coproducts minimizing waste, avril 2004, Norwich, Royaume-Uni, affiche. - Drugs from the seas. J.P. Bergé. BioAsia 2004, Hyderabad (Inde), février substances under the seas. J.P. Bergé. International Conference & Exposition on Marine Living Resources of India for Food and Medecine, Chennai (Inde). - Effective Separation of (lyso)phospholipids by HPLC with the Use of Computer-assisted Optimization. J.P. Bergé, C. Barthomeuf, J. Dumay. 3rd Euro Fed Lipid Congress and Expo: Oils, Fats and Lipids in a Changing World, Edinburgh (RU). - "Production et extraction de lipides en voie aqueuse par bioréacteur enzymatique : application à la valorisation de co-produits et eaux de procédés de l industrie de transformation du poisson." J. Dumay, Jp. Berge, G. Barnathan, P. Jaouen, Les Doctoriales 2004 Université de NANTES, 23 septembre "Séparation par membranes de molécules et de substances marines ", P. Bourseau Et P. Jaouen, IPA World Food Process Exhibition, PARIS novembre 2004 Production et extraction de lipides en voie aqueuse par bioréacteur enzymatique : application à la valorisation de co-produits et eaux de procédés de l industrie de transformation du poisson. J. Dumay, Jp. Berge, G. Barnathan, P. Jaouen, Doctoriales de la Région des Pays de la Loire, LA ROCHE SUR YON France, Septembre 2004 B. Lignot, V. Lahogue, L. Vandanjon, P. Bourseau, Extraction et purification de sulfate de chondroïtine à partir de cartilage de raie par hydrolyse enzymatique et ultrafiltration, Séminaire Archimex, "Les traitements enzymatiques dans les procédés d extraction pour la production de biomolécules innovantes", 21 octobre Des enzymes, pour quoi faire? Panorama des enzymes utilisées dans les procédés industriels, Guerard F.. Séminaire ARCHIMEX: «Les traitements enzymatiques dans les procédés d extraction pour la production de biomolécules innovantes», 20 et 21 octobre 200, Vannes, France. Conférence introductive de 3 heures, sur invitation. - Nouveaux peptides actifs dans les hydrolysats de co-produits de la pêche, Guerard F. Séminaire ARCHIMEX: «Les traitements enzymatiques dans les procédés d extraction pour la production de biomolécules innovantes» 20 et 21 octobre 200, Vannes, France. Communication orale, sur invitation. - "Training sessions organised within the project Valbiomar: the example of University of Nantes" P. Jaouen, Valbiomar Interreg meeting in VIGO (Spain) nov. 2004, Scientific papers : All these documents issued from the general research activity of the partners laboratories have been communicated to interacting SMEs, serving as a basis for training, formation and further collaborations Evaluation of antioxidant activities in by-products hydrolysates, fractionation and concentration of active molecules using separation technologies (ultra- and nanofiltration technologies). Chapitre 6: Full utilisation of the catch. Chabeaud A., Vandanjon L., Jaouen P., Bourseau P., Delannoy C., Johannsson R., Thorkelsson G. & Guérard F.. In: Luten J., Jacobsen C., Bekaert K., Saebo A., Oehlenschlager J. (Editeurs). Seafood research from fish to dish. Quality, safety and processing of wild and farmed fish. Editions Wageningen Academic Publishers (Netherlands), ISBN-10: , pp Enzymatic extraction methods for by-product recovery. F. Guérard. In : Shahidi F. (Editeur). Maximising the value of marine by-products, Part 2: By-products recovery and processing, Editions Woodhead (GB), ISBN , pp Revue bibliographique dans un ouvrage collectif, sur invitation. - Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines. Picot L., Bordenave S., Didelot S., Fruitier-Arnaudin I., Sannier F., Thorkelsson G., Bergé J.P., Guérard F., Chabeaud A., Piot J. M. Process Biochemistry, 41: Antioxidant and free radical-scaveenging activities of «marennine», a blue-green pigment from the diatom Haslea ostrearia responsible for natural greening of cultured oysters, Pouvreau J.-B., Pondaven P., Morançais M., Fleurence F., Guérard F. & Dufossé L., 4th International Congress on Pigments in Food, A challenge to life science, October , Stuttgart-Hohenheim, Germany, pp

39 INTERREG III B Atlantic Area VALBIOMAR Final Report. - Concentration and fractionation of blue whiting peptides hydrolysates by membrane processes. L. Vandanjon, R. Johannsson, M. Derouiniot, P. Jaouen, P. Bourseau (2006). J. Food Engineering. In press - «Technical and economical evaluation of an integrated membrane process producing an aroma concentrate and rejecting clean water from shrimp cooking juices" S. Cros, B. Lignot, P. Bourseau And P. Jaouen Journal of Food Engineering, Vol 77 (3), pp , 2006, - Convenient preparation of picolinyl derivatives from fatty acid esters. N. Dubois, C. Barthomeuf and J.P. Bergé. European. J. Lip. Sci. Technol ; 108 : Adipose tissue compensates for defect of phosphatidylinositol 3 -kinase induced in liver and muscle by dietary fish oil in fed rats. C. Corporeau, C. Le Foll, J.P. Gouygou, J.P. Bergé, J. Delarue. Am. J. Physiol. Endo. Meta ; 290 :E78-E86. - Geographical and seasonal differences in lipid composition and relative weight of by-products from gadiform species. E. Falch, T. Rustad, R. Jonsdottir, N.B. Shaw, J. Dumay, J.P. Bergé, S. Arasaon, J.P. Kerry, M. Sandbakk and M. Aursand. J. Food Composition and Analysis; 19: Improvement of lipid and phospholipid recoveries from sardine (Sardina pilchardus) viscera using industrial proteases. J.Dumay, C. Donnay-Moreno, G. Barnathan, P. Jaouen and J.P. Bergé. Process. Biochem, 41: Lipid composition of the liver oil of the ray Himantura bleekeri. S. Le Néchet, N. Dubois, J.P. Gouygou, J.P. Bergé. Food Chemistry. (in press) Fish and Shellfish Upgrading, traceability. Guerard F., Sellos D., Le Gal Y.: Adv. Biochem. Eng. Biotechnol., 96, Revue bibliographique dans un ouvrage collectif, sur invitation. - Effect of Maillard reaction conditions on browning and antiradical activity of sugar-tuna stomach hydrolysate model system. M.T. Sumaya-Martinez, S. Thomas, B. Linard, A. Binet, F. Guerard. Food Research International, 38(8-9): Preparation and testing of Sardinella protein hydrolysates as nitrogen source for extracellular lipase production by Rhizopus oryzae. Ghorbel S., Souissi N., Triki-Elloue R., Dufossé L., Guérard F., Nasri M. World Journal of Microbiology and Biotechnology 21(1): Marine protein hydrolysates with antioxidant properties. F. Guerard, M.T. Sumaya-Martinez, B. Linard, L. DUFOSSE, Agro FOOD Industry Hi-tech, 16(3), New Access to 1,3-Diketones from Aldehydes. V. Fargeas, M. Baloouch, E. Metay, J. Baffreau, D. M, P. Gosselin, J. P. Bergé, C. Barthomeuf, J. Lebreton. Tetrahedron, 60, Recent advances in fatty acids from lipids of marine organisms: molecular biodiversity, roles as biomarkers, biologically-active compounds, and economical aspects. J.P. Bergé, G. Barnathan. In Advances in Biochemical Engineering/Biotechnology. 96: Ed Y. Le Gal & R. Ulber. Springer. - Method of oil purification, and uses thereof for food and feed J.P. Bergé, C. Delannoy, D. Dhaler, H. Raeder, B. Tilset, E. Torp (brevet déposé le 31/10/2006, n ). - How enzymes may be helpful for upgrading fish by-products: enhancement of fat extraction. J. Dumay, C. Barthomeuf, J.P. Bergé. Journal of Aquatic and Food Product Technology, 13, Marine drugs. J.P. Bergé. Advanced BioTech.3, Desalination of mussel cooking juices by electrodialysis: Effect on the aroma profile (2005) Cros, S., Lignot, B., Bourseau, P., Jaouen, P., Prost C., Journal of Food Engineering, 69 (4), Pages "Etude préliminaire du traitement d effluents contenant de l encre de seiche par procédés à membranes" I. Aloulou, K. Walha, R. Ben Amar, F. Quemeneur Et P. Jaouen, Revue des Sciences de l'eau - Journal of Water Science, accepté le 1 er septembre 2005, in press 39

40 INTERREG III B Atlantic Area VALBIOMAR Final Report. PROSPECTS Indicate whether the project or certain actions will be continued in the future (for example, as part of a future territorial cooperation programme). The partners of VALBIOMAR project wish to widen the range of competences proposed to SME companies to help the improve the framework of innovative actions that can be taken by companies with the Interreg Atlantic area that are involved in fishing, fish trade, aquaculture, seafood processing, derived substance processing, cosmetics, nutraceutical products and therapeutic products to the consumer.. The opinion of participating companies to the Valbiomar events was very strong: "Very good initiative, convivial exchanges between academics and professionals to approach new ways of exploitation", "Many exchanges with the speakers, we created new contacts", "This training stressed the techniques of obtaining hydrolysats in reproducible way", "a good panorama of the membrane techniques applicable to the marine world", "Good balance between technical aspect and applications. We can immediately see the techniques in the concrete " SME s wanted other training sessions and meetings organised on topics such as: regulation, allergens, identification techniques of the molecules, die management (liquid waste processing, by-products...) and wish to go further in the exchange. Whereas some companies limited their networking abilities through confidentiality considerations, others were much more willing to eneter into free discourse between themselves, the Valbiomar partners and other SME s within the wider network. The aim of the Valbiomar network was to make aware the companies of the laboratories competences in the field of marine biotechnologies. However, the participating companies looked for enhanced interactions beyond this initial aim. A synergistic effect emerged: the processing industries want to treat their effluents (for economical and environmental aspects) to market their by-products and to become sustanaible, allowing diversification of their products, while other companies were searching for new products that may emerge from the activities of the processing companies. They found in Valbiomar a dynamic which enables them to make new industry contacts as well as good interactions with scientists within the network. The meetings opened a new networking forum for the SME s that often cut across international and sectorial divides. This presented new commercial opportunities for both suppliers and purchasers that were not present in any other forum.. However, the companies participating in the Valbiomar events and networks looking to innovate (diversification of activities, novel exploitation of by-products through marine biotechnologies or even spinning companies out) sometimes made requests of the laboratory partners that could only be partially met by the existing partners. The laboratories work more easily with international industries with well-structured markets and precise requests on well-targeted products. The participants of the Valbiomar network tended to be SME s wishing to exploit their by-products and to develop new substances but where the product development was often quite vague and early stage. They also tended to lack internal R&D competencies. There needs were thus more general and wide reaching than those of a larger company and the current laboratory network sometimes lacked the complete set of competencies necessary to address these needs. Widening the network is necessary to offer new competences to the Atlantic companies with new actions: NEW ASPECTS - Legislation local, regional, national, EU levels - Traceability and supply management - Wider geographic representation, bringing in Ireland and larger parts of France and the UK. MANAGEMENT and EXPLOITATION OF BY-PRODUCTS - Best practices from other countries - Process improvement - Reducing use of water, energy, generation of wastes - Storage - Conservation - Classification - Transport and logistics - Market studies for by-products : to study alternatives and industry wide initiatives 40

41 INTERREG III B Atlantic Area VALBIOMAR Final Report. IMPROVING COLLABORATIONS - Links between companies producing materials and those with capabilities to obtain high value products - Promotion of clustering and associations e.g. organising workshops and showing good practices in clustering INTEGRATION OF INDUSTRIES IN THE PROJECT - Create a framework for industrial marine biotechnology, headed by an international board integrated by industrial associations, commerce chambers, etc. - Development of cross sectorial and inter-regional Pilot actions with companies INTEGRATION OF LOCAL, REGIONAL AUTHORITIES with competences in the area The existing Valbiomar network does not have much direct input from regional development authorities who may be able to help integrate the network within wider networks (such as terrestrial processing industries). The new Network will seek to involve a much higher level of commitment through the creation of a marine biotechnology regional development forum specifically aimed at public bodies rather than industry. This body would consider best practise, synergistic opportunities and spread awareness of how marine biotechnology can contribute to development in their areas. Opportunities would be afforded for this forum to interact with the industry network. INCUBATORS - Initiatives in place - Development of incubators during the project TRAINING ACTIVITIES - Similar to Valbiomar1 with more exchanges of knowledge between regions - A better use of the on-line training tool - How to get funds to finance the project between labs and companies (utlisiation of existing SME support measures ) DISSEMINATION - An umbrella webpage to regional websites - Electronic newspaper - More diffusion in congress, seminars, international fairs, exhibition HAS THE PROJECT SUCCEEDED IN CONSTRUCTING A TRANS-NATIONAL NETWORK THAT WILL CONTINUE AFTER THE END OF THE PROJECT? YES If yes. In what field and for what types of activities? The network built during this VALBIOMAR project is really original and operative as shown by the interest of SMES for training sessions and joint specific projects. However, the existing network would not be self-sustaining as a truly international effort as more work is needed to strengthen the transnational cooperative aspects, particularly towards the northern European parts of the Atlantic area. Description of the network: (number of partners, typology, status, mode of operation ) 13 partners Laboratories and technical centres ) 8 ( F, SP, Pt, UK ( public) Tranfer: 2 ( PT, UK) Communication 2 ( SP, F) Administration ( F) 1 41

42 INTERREG III B Atlantic Area VALBIOMAR Final Report. In the list of priority themes proposed by the Commission for the period , identify those which are of interest to you: Accessibility and Transport NO Types of activities that could be envisaged. Water Management NO Types of activities that could be envisaged. Maritime Risk Prevention NO Types of activities that could be envisaged. Research & Development Networks YES Types of activities that could be envisaged. Involving more efficiently SMEs and local development agencies in novel product development, by-product management and up-grading through application of marine biotechnology Would you like to receive further information on the future territorial cooperation programme for ? YES 42

43 INTERREG III B Atlantic Area VALBIOMAR Final Report. COMPLIANCE WITH THE GRANT OFFER LETTER and any addenda. (For each question, delete the response that does not apply, and if the response is no, give details) Did the project comply with the terms of the Grant Offer Letter? YES Specify if there were any addenda to the grant offer letter: number, date and grounds. Did the project comply with the partnership presented in the grant offer letter? Yes Did the project comply with the financial plan? Yes for the overall budget (see explanation below) Did the project comply with the schedule presented in the grant offer letter? Yes Concerning a so wide project it was difficult to determine in advance the actual amount of each part of the project (Partners 7, 8, 12, 11) Therefore a modification of the grant offer letter was requested the 4 december In particular, Integrin (Partner 12) spent more on the project than was originally envisaged, allowing them to accept transfer of money within the project consortium from Alicontrol (Partner 11). This was because they had engaged with a wider industry base than had been planned: in particular they engaged in much more depth with the salmon industry. The rather diffuse nature of seafood businesses in Scotland also meant more time was required in developing dialogue with these businesses. Did the project comply with the obligations regarding the inclusion of the programme logo and the European Union flag in all information and publicity actions? YES COMPLIANCE WITH COMMUNITY POLICY (Cf. Application Form point 7) Did the project comply with national and Community legislation on: - public procurement? YES - fair competition? YES - the environment? YES - equal opportunities? YES Justify your answers. No procurement activities occurred as part of the project. Likewise there were no competition issues that arose as all of the work undertaken was precompetitive and equal access to the network and its capabilities was offered to all interested parties, particularly SME s. The project was widely disseminated in all appropriate languages to prevent any partner country being disadvantaged. Concerning the environment, the basis of the project is a better and sustainable use of marine biological resources. None of the technical aspects of the project posed inherent risk to the environment and the project utilised environmentally friendly methods where possible ( ; web based learning tools etc). All of the partners have equal opportunity policies in place. No gender, sexual orientation, race or disability issues arose during the project 43

44 INTERREG III B Atlantic Area VALBIOMAR Final Report. DECLARATION OF THE LEAD PARTNER As Lead Partner, I hereby declare that the information in this final activity report is the faithful reflection of the actions and results of the project throughout its duration. Date: Surname and forename (in capitals) : Michel POUYLLAU Position within the organisation : President Signature and stamp: 44

45 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 1: PROJECT SCHEDULE AND KEY DATES Date of submission of the application form Date of final approval of the file by the Steering Committee Date of signature of the grant offer letter by the lead partner Date project started Date of modification application N 1 (if any) Date 01/11/ /03/ /05/ /01/ /01/2004 Comments (if any) Date addendum N 1 signed 27/09/2004 Signed by the Management Authority Conseil Regional de Poitou Charentes Date of modification application N 2 (if any) Date addendum N 2 signed Date project ended 04/12/2006 Signed by Lead Partner 31/12/

46 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 2: FILING OF ORIGINAL SUPPORTING DOCUMENTS (of expenditure, income, etc. ) in application of Article 4 of the grant offer letter Lead Partner and Partners Place(s) filed Lead Partner Partner 1 Partner 2 (Legal representative) Partner 3 Partner 4 Partner 5 Partner 6 Partner 7 Partner 8 Partner 9 Partner 10 Partner 11 Partner 12 Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE Ruoa 13, rue Alain Barbe Torte Nantes - FRANCE Museum national d histoire naturelle 57 Rue Cuvier Paris - FRANCE IFREMER, Centre de Nantes Direction des affaires financières rue de l'ile d'yeu BP Nantes cedex 03 - FRANCE Université de Nantes - Faculté des Sciences et des Techniques Pôle Mer Littoral Rue de la Houssinière BP Nantes Cédex 03 - FRANCE Université de Bretagne Sud Présidence Service Recherche Rue de St Maudé BP Lorient Cédex - FRANCE Université de Bretagne Occidentale Présidence Service Financier 3 rue des Archives CS Brest Cedex- FRANCE IPIMAR Avenida Brasilia Lisboa - PORTUGAL Universidad de La Laguna Universitario de Bioorganica "Antonio Gonzales" La Laguna - ESPAGNE Technopole Quimper-Cornouaille 2, rue Bernard Guillemot Quimper - FRANCE CETMAR - Centro tecnologico del mar Rua Eduardo Cabello s/n Vigo - ESPAGNE Alicontrol R. Fernando Vaz - Lote 26-B Lisboa - PORTUGAL Integrin Advanced Biosystems Ltd Marine resource Centre, Argyll Scotland PA37 1SE - ROYAUME UNI 46

47 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 3: FILING OF KEY DOCUMENTS OF THE PROJECT Document Place(s) filed Grant offer letter Letters of intent Partnership agreement Modification (if any) Addendum (if any) Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE Université de La Rochelle Présidence - Services financiers 23, avenue Albert Einstein La Rochelle Cedex 9 - FRANCE 47

48 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 4: SUMMARY OF ERDF PAID See Excel file attached in the annexes 48

49 Interreg III B Espace Atlantique" RECAPITULATIF DU FEDER VERSE (Annexe 4 du rapport final) Numéro du projet - Acronyme : VALBIOMAR Répartition des reversement effectués Référence du versement FEDER reçu par le chef de file de l'autorité de paiement Vérification automatique des reversements effectués par le chef de file aux partenaires (somme des reversements effectués) Chef de file : Partenaire 1 : Partenaire 2 : UNIVERSITE DE LA ROCHELLE LABORATOIRE BIOTECHNOLOGIE RUOA - Réseau des Universités de l'ouest Atlantique - NANTES Station Biologie Marine MNHN -29 CONCARNEAU PAYS : PAYS : PAYS : Montant Date (dd/mm/yyyy) Vérif. Montant Vérif. Montant France France France Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Avance (le cas échéant) ,50 15/10/ ,34 #REF! 8 808,92 24/01/ ,49 24/01/ ,08 24/01/2005 Vérif. Remboursement n ,24 26/11/ ,32 Attention 1 514,03 24/01/ ,28 24/01/2005 Remboursement n ,43 27/01/ ,43 Attention ,46 11/05/2005 Remboursement n ,32 19/05/ ,30 Attention ,21 30/05/ ,25 30/05/2005 Remboursement n ,26 22/09/ ,85 Attention Remboursement n ,48 22/11/ ,48 Attention 1 350,28 05/12/2005 Remboursement n ,54 20/03/ ,54 Attention ,70 07/04/ ,80 07/04/2006 Remboursement n ,29 20/03/ , ,12 07/04/ ,99 07/04/ ,23 07/04/2006 Remboursement n ,96 30/05/ ,96 Remboursement n ,47 23/11/ ,47 Attention Remboursement n ,69 21/12/ ,69 Attention 1 772,92 25/01/ ,13 25/01/2007 TOTAL , ,67 Attention , , ,98 ReversementFEDER_LaRochelleAnnex4_16_03_07.xls 1/4

50 Interreg III B Espace Atlantique" RECAPITULATIF DU FEDER VERSE (Annexe 4 du rapport final) Numéro du projet - Acronyme : VALBIOMAR Répartition des reversement effectués Partenaire 3 : Partenaire 4 : Partenaire 5 : Partenaire 6 : Référence du versement IFREMER - NANTES UNIVERSITE DE NANTES ISOMER UNIVERSITE DE BRETAGNE SUD (UBS) LORIENT UNIVERSITE DE BRETAGNE OCCIDENTALE (LUMAQ) QUIMPER -UBO PAYS : PAYS : PAYS : PAYS : France France France France Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Avance (le cas échéant) 1 731,82 24/01/ ,00 24/01/ ,82 24/01/2005 Remboursement n ,45 24/01/2005 Remboursement n ,99 11/05/ ,40 11/05/2005 Remboursement n 3 Remboursement n 4 Remboursement n ,80 30/05/ ,70 30/05/ ,05 30/05/ ,85 30/05/ ,10 05/12/2005 Remboursement n 6 Remboursement n ,65 07/04/ ,64 07/04/ ,28 07/04/ ,54 07/04/2006 Remboursement n 8 Remboursement n 9 Remboursement n 10 TOTAL , , , ,69 ReversementFEDER_LaRochelleAnnex4_16_03_07.xls 2/4

51 Interreg III B Espace Atlantique" RECAPITULATIF DU FEDER VERSE (Annexe 4 du rapport final) Numéro du projet - Acronyme : VALBIOMAR Répartition des reversement effectués Partenaire 7 : Partenaire 8 : Partenaire 9 : Partenaire 10 : Référence du versement INIAP/IPIMAR - LISBOA UNIVERSIDAD DE LA LAGUNA -ULL TECHNOPOLE QUIMPER CORNOUAILLE FUNDACION CETMAR PAYS : PAYS : PAYS : PAYS : Avance (le cas échéant) Remboursement n 1 Remboursement n 2 Remboursement n 3 Remboursement n 4 Remboursement n 5 Remboursement n 6 Remboursement n 7 Remboursement n 8 Remboursement n 9 Remboursement n 10 TOTAL Portugal Espagne France Espagne Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) 3 963,20 04/02/ ,53 30/03/ ,24 24/01/ ,06 04/02/ ,08 24/01/ ,48 04/02/ ,25 11/05/ ,92 07/06/ ,54 30/05/ ,92 07/06/ ,38 13/12/ ,66 05/12/ ,54 19/12/ ,73 21/04/ ,31 07/04/ ,05 07/04/ ,77 07/04/ ,78 15/06/ ,68 07/06/ ,35 15/06/ ,76 08/02/ ,88 25/01/ , , , , ,94 23/11/2006 Vérif. ReversementFEDER_LaRochelleAnnex4_16_03_07.xls 3/4

52 Interreg III B Espace Atlantique" RECAPITULATIF DU FEDER VERSE (Annexe 4 du rapport final) Numéro du projet - Acronyme : VALBIOMAR Répartition des reversement effectués Partenaire 11 : Partenaire 12 : Partenaire 13 : Partenaire 14 : Référence du versement ALICONTROL - LISBOA INTEGRIM ADVANCED BIOSYSTEMS Ldt PAYS : PAYS : PAYS : PAYS : Portugal Royaume-Uni Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Montant Date (dd/mm/yyyy) Vérif. Avance (le cas échéant) 2 237,20 04/02/ ,98 04/02/2005 Remboursement n 1 Remboursement n ,33 23/05/2005 Remboursement n ,32 07/06/ ,59 13/06/2005 Remboursement n 4 Remboursement n ,52 13/12/2005 Remboursement n 6 Remboursement n ,02 24/04/2006 Remboursement n ,15 15/06/2006 Remboursement n ,53 23/11/2006 Remboursement n 10 TOTAL , , ReversementFEDER_LaRochelleAnnex4_16_03_07.xls 4/4

53 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 5: PROGRAMME INDICATORS TABLE COMPARING FORECASTS AND ACHIEVEMENTS ON INDICATORS AT THE END OF THE PROJECT Provide information only for the indicators relating to the measure on which your project was financed (Cf. Application Form point 12 and 3.10) PRIORITY A Performance and results indicators - (Quantify the indicators) Forecast Actual MEASURE A-2 Number of technological research and development organisations that have 8 8 benefited Number of grant beneficiaries - 12 Number of studies elaborated - 3 Number of public-private partnerships 3 18 Number of research-sme cooperations Number of co-operation agreements between organisations and businesses - 18 OTHER INDICATORS WROTE IN VALBIOMAR PROPOSAL Number of centres of excellence which have been sustained 1 1 Number of papers issued 10/year n.c Number of SMEs integrating the results of the project in their activity Justification of any discrepancies between the forecast and actual performance indicators, if any No discrepancy. PRIORITY C Performance and results indicators - (Quantify the indicators) Forecast Actual MEASURE C-3 Number of training actions carried out 8 13 Number of awareness-raising activities carried out 2 15 Number of conferences organised Number of renewable energy projects NA NA Number of participants in the training actions 10/session 100 OTHER INDICATORS WROTE IN VALBIOMAR PROPOSAL Number of participants in awareness-raising activities/conferences Number of Website consultations 100/month 228/month Justification of any discrepancies between the forecast and actual performance indicators, if any 49

54 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 6: PROJECT INDICATORS For projects with indicators in addition to those for the measure in question. Performance and results indicators on the basis of those proposed by the Project in its Application Form - (Quantify the indicators) Forecast Actual 50

55 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 7: USEFUL CONTACTS JOINT SECRETARIAT Région Poitou-Charentes Programme INTERREG III B "Espace Atlantique" 15, rue de l'ancienne Comédie BP Poitiers Cedex (France) Tel: 33(0) Fax: 33(0) [email protected] Website: SPAIN Ministerio de Hacienda Dirección General de Fondos Comunitarios. Paseo de la Castellana MADRID (España) Contact: Cecilio OVIEDO Tel: Fax: [email protected] Website: FRANCE Conseil Régional des Pays de la Loire. Direction de la Recherche, de l'enseignement Supérieur, de l'international et de l'europe NANTES CEDEX 9 Contact: Isabelle GARDON Tel: (0) Fax: (0) [email protected] IRELAND Border Midlands and West Regional Assembly The Square. Ballaghadreen. Co Roscommon (Ireland) Contact: Michael O'BRIEN Tel: (0) Fax: (0) [email protected] PORTUGAL Ministério das Cidades, Administração Local, Habitação e Desenvolvimento Regional Unidade de coordenação nacional INTERREG III Rua da Alfândega, nº Lisboa ( Portugal ) Contact: José SOEIRO Tel: Fax: [email protected] Website: UNITED KINGDOM ODPM Office of the Deputy Prime Minister Eland House, Bressenden Place, Floor 3/J5 LONDON SW 1E 5DU (United Kingdom) Contact: Robert LOWENSTEIN / Barbara CURLEY Tel: Fax: [email protected] Website: 51

56 INTERREG III B Atlantic Area VALBIOMAR Final Report. ANNEXE 8: OTHER PUBLICITY OR INFORMATION DOCUMENTS PRODUCED WITHIN THE FRAMEWORK OF THE PROJECT 52

57 045 Valbiomar Project du 01/01/2004 au 31/12/2006 Total per action in the Final Report - 21 june 2007 (Proposed by Ruoa - Lead Partner Assistant) 5 / Com 21% 1/ Management 4% 2 / Lab Transfer 23% 4 / Coop Lab Sme's 30% 3 / Com to Sme's 22%

58

59 Projet VALBIOMAR Valorisation biotechnologique des ressources marines Durée : 3 ans (01/04 12/06) Budget du projet : Fonds FEDER : Pour une meilleure utilisation des ressources marines et de nouveaux produits commercialisés par les PME La situation actuelle des ressources marines est celle d'un gaspillage considérable, qu il s agisse des produits de la pêche, de l aquaculture ou des co-produits générés lors de leur transformation. Et pourtant de nouveaux procédés d extraction de matériel biologique sont élaborés et de nouvelles substances utiles produites à partir d organismes marins sont identifiées par les laboratoires des régions atlantiques. Sous différentes formes, ces ressources biologiques sont utilisables et profitables pour de nombreux secteurs. Aujourd hui, il est possible de valoriser mieux tout en pêchant moins! Utiliser les biomasses pêchées non exploitées et leurs co-produits! Les industries de transformation des produits de la mer génèrent des co-produits pouvant atteindre 50% des tonnages traités. Traditionnellement, ces déchets sont transformés en hydrolysats, en farine de poisson ou bien sont solubilisés sous forme d'ensilages destinés, en particulier, au marché des «pet-food». De nouvelles méthodes de traitements biotechnologiques des biomasses pêchées et des co-produits marins ont été développées par les laboratoires du projet VALBIOMAR. Ces techniques permettent la production de molécules à haute valeur ajoutée (arômes, colorants, peptides, lipides, protéines ) avec un potentiel spécifique dans les domaines de la santé, de l alimentation humaine et animale mais aussi dans d autres domaines industriels comme celui des agents anti-fouling. Des substances utiles produites par des organismes vivants! La biodiversité marine est extrêmement riche. Cependant, les ressources en molécules associées à cette biodiversité sont sousexploitées. A cet égard, la situation de l'europe contraste avec celle d'autres pays aux ambitions maritimes reconnues telles que le Japon, l'australie, le Canada ou les Etats- Unis qui développent des programmes pour l identification des substances naturelles produites par les organismes marins de leurs eaux territoriales. La spécificité des faunes et flores marines de la côte atlantique rend possible le développement du potentiel commercial de produits originaux susceptibles d'être exploités localement (aquaculture) : production de substances allopathiques par élevage d invertébrés, lutte biologique contre salissures marines Les laboratoires à votre écoute, prêts à coopérer! Le projet VALBIOMAR permet la constitution d un réseau atlantique de compétences au service des PME. Les laboratoires «VALBIOMAR» (Bretagne, Pays de la Loire, Poitou-Charentes, Galice, Ecosse, Portugal) diffusent leurs savoir-faire aux PME pour des coopérations concrètes et des exploitations réelles des résultats de recherche dans les secteurs de la pêche, de l aquaculture, de l alimentation humaine et animale, de la cosmétique, de la santé, de l entretien naval Avec la participation de l Union Européenne Projet cofinancé par le FEDER

60 Antioxidant - University of Bretagne Occidentale Quimper - FRANCE Dr Fabienne Guérard, Dr Boris Linard, A. Chabeaud, phd; D. Laroque, phd; Dr Laurent Dufossé 3rd May 2006

61 Activities related to Valbiomar October May Organization of a training session for enterprises 2 - Participation at several Conferences 3 - Activities with SME s

62 1 Organization of a training session for SME s

63 Organization of a training session in Quimper Addressed to : Managers, R&D managers, R&D technicians Companies from Food Industry, Cosmetics, Pharmaceutics, Pet-food NOUVEAUX ACTIFS MARINS : hydrolyser pour mieux VALORISER! NEW BIOACTIVE MOLECULES in MARINE HYDROLYSATES 4 November 2005 from 9:00 a.m. to 5:30 p.m., in QUIMPER

64 8 Meetings in order to organize the seminar March 2005: F Guérard (UBO) & M Robin (Technopole) July 2005, the 1rst: F Guérard (UBO) & C Carmagnac (Technopole) July 2005, the 13rd: 10 people, phoning meeting (organization of the lectures) September 2005, the 6th : F Guérard (UBO) & C Carmagnac (Technopole) September 2005, the 13rd: F Guérard (UBO) & C Carmagnac (Technopole) September 2005, the 22Th: F Guérard (UBO) & C Carmagnac (Technopole), students of the lab for the practical session organization October 2005, the 10th: F Guérard (UBO) & C Carmagnac (Technopole), students of the lab for the practical session organization Then every day, from October, the 24th to the 4th of November NOUVEAUX ACTIFS MARINS : hydrolyser pour mieux VALORISER! NEW BIOACTIVE MOLECULES in MARINE HYDROLYSATES 4 November Quimper

65 Diffusion, communication - Writing of the invitation letter (UBO & TCQ) in French in English -Mailing (week n 39): TCQ 253 invitations sent to SME s 60 invitations sent to technical centers, institutes, etc. 23 invitations to regional and specialist press - 10 Direct contacts during the SEAFOODplus meeting in Grandville - Diffusion via several web sites TCQ UBO, Technopôle Brest Iroise, TCQ, letter Votre Technopole, debate organized by TCQ, Valbiomar web site,

66 A network of laboratories dedicated to the biotechnological exploitation of marine resources The Valbiomar poster for the meeting in Granville Cendrine Carmagnac,, TQ VALBIOMAR, an Atlantic inter-regional Platform for the transfer of technologies and communication For SMEs of Atlantic Area companies in nutrition, health, cosmetics,...

67 Participants and contributors Number of participants : 30 participants from which 18 participants from Brittany Type of participants : 20 SME s (+1 TQC) / 2 technical centers et 8 scientists (researchers, phd students) TOTAL : 44 people

68 30 Participants Girex Madame Gwenaëlle ROLLAND chef de projet agroalimentai Lyven Monsieur Jean Paul PAPIN commercial Agrimer Monsieur Eric GUIVARCH responsable laboratoire CEMPAMA - AGROCAMPUS Madame Morganne NEDELEC formateur COMAPECHE / COMABOKO Madame Séverine AUBERTIN Responsable R&D CTPP Coopérative de Traitement des Produits de la Pêche Madame Laurence GUIMAS Ingénieur R&D DIELEN Monsieur Bernard NOEL Laboratoires Apolia Monsieur Sim SIMON Pharmacien Laboratoires Cosmeceutic Monsieur Victor EVRARD Gérant Laboratoires Océalys Madame Françoise BRANQUET Responsable R&D Laboratoires Océalys Madame Sophie MARCHADOUR formulatrice Laboratoires Science et Mer SIMER Madame Véronique KERJEAN Technicienne LET2E Monsieur Laurent VANDANJON Maitre de conférence LET2E Monsieur Patrick BOURSEAU Professeur Armement Le Saltimbanque Monsieur Karl BURGAUD marin pêcheur Nestlé Purina Petcare Monsieur RIO formulateur Océane alimentaire Monsieur Arnaud TANNIOU Responsable production adj OLMIX Monsieur Fabrizio FORDIANI Assistant recherche Phosphotec Monsieur Philippe ROY Responsable production Laboratoire RIVADIS Madame Nathalie LARNAUDIE Responsable R&D ROUSSELOT Madame Anne-Marie BUCHERT Technicienne biochimie SPF DIANA Madame Céline ORAIN ingénieur R&D SPI DIANA Madame Céline BERGER responsable innovation ADRIA NORMANDIE Monsieur Christophe MOREL ingénieur R&D ADRIA NORMANDIE Monsieur Alexandre LACOMBE Ingénieur R&D CBB Développement Madame Nathalie LETACANNOUX Ingénieur projets LBBM - Université de CAEN Monsieur Noussithe KOUETA chercheur LBBM - Université de CAEN Madame Estelle LE BIHAN doctorante VOLVIVE Monsieur Roger VILLAUME technicien RUOA Madame Laurence GAREAUX chargée de mission

69 13 Contributors Technopole Quimper-Cornouaille Michèle Jéquel Communication Technopole Quimper-Cornouaille Cendrine Carmagnac European project MNHN Concarneau Dr Martine Fouchereau-Péron Scientist MNHN Concarneau Pr Yves Le Gal Scientist STAM IFREMER Nantes Dr Jean-Pascal Bergé Scientist LBCB La Rochelle Pr Jean-Marie Piot Scientist LBCB La Rochelle Pr Frédéric Sannier Scientist LBCB La Rochelle Dr Laurent Picot Scientist Laboratory ANTiOX - Quimper Dr Fabienne Guérard Lecturer Laboratory ANTiOX - Quimper Dr Laurent Dufossé Lecturer Laboratory ANTiOX - Quimper Delphine Laroque phd student Laboratory ANTiOX - Quimper Aurélie Chabeaud phd student Laboratory ANTiOX - Quimper Aurélien Denès EPHE student

70 Program: Morning: 6 lectures Discussion (company testimonies) Afternoon: Laboratory practice

71 Program 9:00 9:15 Reception of participants Dr Fabienne GUERARD, ANTiOX Laboratory, Université de Bretagne Occidentale A.M. - CONFERENCES 9:15 9:30 VALBIOMAR project presentation Pr. Jean-Marie PIOT, Laboratoire de Biotechnologie et Chimie Bio-organique (LBCB), Université de La Rochelle, Pr. Yves LE GAL, Station de Biologie Marine de Concarneau, Muséum National d Histoire Naturelle (MNHN) 9:30 10:15 Proteases used in the solubilisation of by-products and preparation of active compounds Dr Jean-Pascal BERGÉ, department of Marine Food Sciences and Techniques (STAM), IFREMER Nantes, Dr Fabienne GUERARD, ANTiOX Laboratory, Université de Bretagne Occidentale 10:15 10:45 Enzymatic hydrolysis using the ph-stat method Pr. Frédéric SANNIER, Laboratoire de Biotechnologie et Chimie Bio-organique (LBCB), Université de La Rochelle 10:45 11:00 Coffee break 11:00 11:15 Marine hydrolysates and anticancer/antihypertensive activities Dr Laurent PICOT, Laboratoire de Biotechnologie et Chimie Bio-organique (LBCB), Université de La Rochelle 11:15 11:30 Marine hydrolysates and calcitonin/cgrp-like and gastrin activities Dr Martine FOUCHEREAU-PERON, Station de Biologie Marine de Concarneau, Muséum National d Histoire Naturelle (MNHN), Dr Rozenn RAVALLEC-PLE, Laboratoire de Technologies des Substances Naturelles, Université de Lille 11:30 11:45 Marine hydrolysates and antioxidant/free radical scavenging activities Delphine LAROQUE, ANTiOX Laboratory, Université de Bretagne Occidentale 11:45 12:30 Discussion led by Pr. Yves LE GAL, Station de Biologie Marine de Concarneau (MNHN) & Cendrine CARMAGNAC, Technopole Quimper-Cornouaille Company testimonies on examples of cooperation with research centers : Céline BERGER, SPI DIANA Laurence GIMAS, Coopérative de Traitement des Produits de la Pêche (CTPP), Boulogne sur Mer What kind of co-operations can the VALBIOMAR laboratory network offer you? 12:30 14:00 Lunch

72 P.M. LABORATORY PRACTICE 2:00 3:00 Evaluation of protein solubilisation (ph-stat method and other methods) Aurélien DENES, ANTiOX Laboratory, Université de Bretagne Occidentale 3:00 4:00 The importance of reproducibility : Size Exclusion Chromatography - a performing tool Aurélie CHABEAU, ANTiOX Laboratory, Université de Bretagne Occidentale / Université de Bretagne Sud 4:00 5:30 Case studies: biological activities and enzymatic hydrolysates prepared in controlled conditions The VALBIOMAR network laboratories 5:30 Closure

73 Preparation of a slide mask in order to standardize the oral communications

74

75 Budget INCOMINGS Registration fees : / participant Number of registration : 29 people TOTAL INCOMINGS : OUTGOINGS Coffee break : euros Restaurant (Thursday evening) for intervenants : Lunch (Friday) 40 people : 800 TOTAL OUTGOINGS : TOTAL : euros to be shared between the 2 organizations : ANTiOX et TQC Other expenditures (not evaluated): mailing, proceedings, participant traveling expenses, etc

76 Final assessment (from TCQ and (from TCQ and ANTiOX) Strong points: 1 - Good quality of the exchanges between participants themselves, and with lecturers. 2 - Good balance between the lectures / debate / practical session. => to make easier the exchanges 3 - Company testimonies on examples of cooperation with research centers 4 - Laboratory practice : - concrete & complementary approach of the theoretical presentations. - presentation by 2 «juniors (phd students)», with a senior as supervisor. 5 - Duration/Date : one single day, Friday (end of the week) =>more easy to mobilize industrial partners. 6 - Local lunch : that saves a lot of time ; more simple due to the high number of participants.

77 1 - Good quality of the exchanges between participants and with lecturers.

78 2 - Good balance between lectures / debate / practical session.

79 3 - Company testimonies on cooperation examples with research centers

80 3 - Company testimonies on examples of cooperation with research centers

81 3 - Company testimonies on examples of cooperation with research centers Yves Le Gal, chairman

82 Local lunch : Coffee break :

83 4 - Laboratory practice : Workshop ph-stat

84 Étude de cas : Influence du contrôle du ph sur l hydrolyse

85 Suivi de l hydrolyse DO 220nm 0,8 0,7 0,6 0,5 0,4 0,3 Blanc T1 T2 T3 T4 0,2 0,1 0, Temps (minutes)

86 4 - Laboratory practice : Workshop ph-stat

87 4 - Laboratory practice : Workshop ph-stat

88 4 - Laboratory practice : Workshop SEC-FPLC

89 4 - Laboratory practice : Workshop SEC-FPLC

90 Principe de fonctionnement de la chaîne HPLC Échantillon Solvant Pompe Détecteur à barrette de diodes Injecteur automatique Colonne Acquisition et traitement des données

91 Principe de fonctionnement de la chromatographie d exclusion stérique Grosses molécules exclues Petites molécules incluses Retard Granule de gel d exclusion Elution avec le V mort

92 Extraction à différentes longueurs d onde Exemples : Extraction à nm : détection des liaisons peptidiques Extraction à 280 nm : détection des composés aromatiques Echantillon a-T2 20µL Contrôle du ph d'hydrolyse - Prétitration à ph 8 (ph-stat) DO 0,65 0,6 0,55 0,5 0,45 0,4 0,35 0,3 0,25 0,2 0,15 0,1 0,05 0-0, nm 280 nm Te mps (min)

93 Suivi de l évolution du profil chromatographique A 220nm 0,8 0,7 0,6 0,5 0,4 0,3 0,2 Alcalase E/S = 0,9% Volume injecté : 30µL - Concentration : 10mg/mL Échelle de calibration (Da) T1 (8 min) T2 (33 min) T3 (75 min) T4 (120 min) Blanc 0, ,1 Temps (min)

94 Profil de poids moléculaires A 220nm Contrôle du ph d'hydrolyse - Prétitration à ph 8 (ph-stat) 0,65 0,6 0,55 0,5 0,45 0,4 0,35 0,3 0,25 0,2 0,15 0,1 0,05 0-0, Temps (min) a-T2 20µL log (PM) Nécessité d établir une échelle de calibration (Da) 4,5 4 3,5 3 2,5 2 1,5 1 0,5 Courbe de calibration de la colonne HR y = -0,0985x + 5,7326 R 2 = 0, Temps de rétention (min) PM > <100 % de peptides 1,21 2,84 25,42 25,33 36,12 8,35

95 Reproductibilité des lots 0,55 0,45 Reproductibilité des hydrolyses à ph contrôlé Échelle de calibration (Da) T1 20µL A T1 20µL B 0,35 A 220nm 0,25 0,15 0,05-0, Temps (min)

96 La SEC-FPLC : un outil précieux Indication sur la nature des composés injectés Suivi de l hydrolyse au cours du temps Obtention du profil de poids moléculaires du mélange Indication sur la reproductibilité des lots

97 Weak points Final assessment (from TCQ and ANTiOX) Too much participants : 30 people! but it was impossible to decline registrations (on which criterion?) Consequence: for the laboratory practice, we have split up the participants in 2 groups (15 people by group). For the future : A good number : below 8 people in the lab!

98 Final assessment (from participants) On the whole, people said that -The training session was (very) interesting -The combination lectures with laboratory practice was appreciated: Relevance of the lectures, content of the talks (but sometimes too much lectures!) Concerning the organization : very satisfied Have you got any subject to be studied in a next seminar: Intoxication risk, allergy, regulations (rules) Have you got any remarks to make about the seminar : Have you got any remarks to make about the seminar : See you soon!!!

99 Regional press

100 Regional press

101 Regional press link,

102 2 - Participation at several Conferences

103 2.1 - Participation at the 35th WEFTA meeting September Antwerp, Belgium Oral communication Session 13. Full utilization of the catch: Chairperson Ragnar Olsen Aurélie Chabeaud University West Brittany / University of south Brittany Evaluation of antioxidant activities in by-product hydrolysates: fractionation and concentration of active molecules using ultra- and nanofiltration membranes

104 Participation at the UNIVERSITE DE PRINTEMPS "Dynamiques et représentations du littoral", Saint-Nazaire, FR April 2006, 24th-28th 28th

105 2.3. May 2006, the 14th General ASSEMBLY of Technopole Quimper 15h00 Les Actions 2005 liées à la MER La parole est donnée aux Entreprises accompagnées dans le domaine de la Mer Oral communication : Assessment of the VALBIOMAR seminar

106 3 - Activities with SME s

107 Observation: one of the consequences of the valbiomar seminar MOBILIZATION of SME s INCREASE collaborations between our lab and SME s

108 4 Oral presentations to Companies Les co-produits de la pêche: une nouvelle source d actifs marins Marine by-products: a new source of bioactive compounds Tuesday, the 3rd of January 06 Thursday, the 6th of April 06 Friday, the 7th of April 06 Company (south of France) Pharmaceutical company Pharmaceutical company people working in technological transfer centers R&D managers (2) 3 participants Director, R&D managers (4) 15 participants Presentation of the VALBIOMAR project and of some examples of bioactive compounds identified in marine hydrolysates

109 New series of analyses have been performed

110 Thank you for your attention