Brenda W.J.H. Penninx, Ph.D page 1

Transcription

1 Brenda W.J.H. Penninx, Ph.D page 1 CURRICULUM VITAE BRENDA WJH PENNINX, PH.D. DATE December 2009 WORK ADDRESS Department of Psychiatry VU University Medical Center, AJ Ernststraat HL Amsterdam, The Netherlands Tel: Fax: b.penninx@ggzba.nl or b.penninx@vumc.nl DATE OF BIRTH July 27, 1970 PLACE OF BIRTH Beuningen CITIZENSHIP Dutch EDUCATION Undergraduate, BIomedical Health Sciences, Catholic University of Nijmegen, The Netherlands. Degree obtained on August 29, Graduate, Master of Science in Epidemiology, Biomedical Health Sciences, Catholic University of Nijmegen, The Netherlands. Degree obtained on August 28, Ph.D. in Medicine, Faculty of Medicine, Vrije Universiteit Amsterdam, The Netherlands. Degree obtained on October 4, ACADEMIC AFFILIATIONS 2007-present Professor of Psychiatric Epidemiology, Department of Psychiatry / EMGO+ Institute / Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands present Joint Professor, Departments of Psychiatry, Leiden University Medical Center and University Medical Center Groningen, The Netherlands Associate Professor, Department of Psychiatry / EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands Associate Professor, Departments of Internal Medicine and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem NC Assistant Professor, Departments of Internal Medicine and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem NC Senior Researcher, EMGO Institute, VU University Amsterdam, The Netherlands Visiting Scientist, Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, MD Visiting fellow, Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD PhD-student, EMGO Institute, VU University, Amsterdam, The Netherlands. OTHER PROFESSIONAL EXPERIENCE AND COMMITTEE INVOLVEMENT 2007-present Member, VIDI review committee, NWO

2 Brenda W.J.H. Penninx, Ph.D page Member, Selection committee for the Dr. Hendrik Muller Award voor Gedrags- en Maatschappijwetenschappen. KNAW 2007-present Member of Health Council Committee, Committees Predictive Medicine and Undernutrition in the Elderly 2006-present Member, Rubicon review committee, NWO 2006-present Member, KNAW commissie Internationaal beleid Member, Young Academy, KNAW 2004-present Program leader, Mental health program, EMGO Institute, VU University Medical Center, Amsterdam 2004-present Scientific Director, Netherlands Study of Depression and Anxiety (NESDA) Director, Geriatric Research Center, Wake Forest University School of Medicine, Winston Salem, NC Consultant for the working group on Prevention of disability in frail older persons. Meeting in Florence, Italy Consultant in Healthy Brain Aging workshop, a NIH appointed advisory panel, cosponsored by National Institute on Aging, National Institute of Mental Health and National Institute of Neurological Disorders and Stroke. HONORS AND AWARDS 2006 Fellow, Gerontological Society of America 2005 Member, The Young Academy of the Royal Dutch Academy of Sciences and Arts Fellowship, Brookdale Foundation Leadership on Aging award, Brookdale Foundation, New York Epidemioloog B (registered senior epidemiologist) by the Netherlands Society of Epidemiology 1997 EMGO-Award from the VU University, for best scientific article in Stipend, Niels Stensen Stichting Amsterdam for a visiting fellowship at the National Institute on Aging in Bethesda, MD, USA ($0.1 million) in Scholarship award obtained from Royal Dutch Academy of Arts and Sciences (KNAW) to attend the Epidemiology Summer School, New England Epidemiology Institute, Boston MA, USA 'Dittmer fund' award from VU University for attending the Epidemiology Summer School, New England Epidemiology Institute, Boston MA, USA. SOCIETY MEMBERSHIP Netherlands Society of Epidemiology ( present) Dutch Federation of Medical Scientific Societies ( present) Gerontological Society of America ( present) American Psychosomatic Medicine Association (2006-present) Young Academy, Royal Dutch Academy of Sciences and Arts ( ) TEACHING EXPERIENCE Mental Health Research, research master course in biomedical sciences, 200 credit hours, VU University, 2009 Psychiatric Epidemiology, Postdoctoral Education Epidemiology (POE), VU University Medical Center, 2007, 2008, 2009 Psychosomatic Medicine, Course in honours program for excellent interdisciplinary students, 200 credit hours, VU University Amsterdam, February-March Social environment and health, Postdoctoral education, Netherlands Institute of Health and Environmental Sciences (NIHES), Rotterdam, The Netherlands, Geriatrics Fellows training on Physical health consequences of late-life depression, Wake Forest

3 Brenda W.J.H. Penninx, Ph.D page 3 University School of Medicine, in 2002, 2003, 'Population Health and Epidemiology', Wake Forest University School of Medicine 20 credit hours for medical students, Journal club for fellows, Section Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, , one hour bi-weekly. 'Basic principals in epidemiologic research'. Post Doctoral Training Program in Epidemiology. VU University, 40 credit hours, 8 students, 'Logistic regression and survival analyses'. Post Doctoral Training Program in Epidemiology. VU University, 40 credit hours, 10 students, 1996 and 'Basics of Biostatistics'. Post Doctoral Training Program in Epidemiology. VU University, 10 credit hours, 30 students, SUPERVISION OF PH.D STUDENTS 1. Graziano Onder, Wake Forest University, Winston Salem, Graduated in April Thesis: ACE-inhibitors and physical decline in old age. 2. Arlette Hesselink, Vrije University. Graduated on October 17, Thesis: Educating asthma and COPD patients in general practice. 3. Matteo Cesari, Wake Forest University School of Medicine, Winston Salem, Graduated in November Thesis: Inflammation and cardiovascular disease in old age. 4. Bianca Schalk, Vrije University. Graduated on February 11, Thesis: Albumin and physical health decline in old age. 5. Coen van Gool, University of Maastricht. Graduated on June 10, Thesis: The course of chronic disease, depression, and health behavior in longitudinal perspective. Findings concerning the epidemiology of aging. 6. Annemarie Koster, University of Maastricht. Graduated on December 22, Thesis: Socioeconomic health differences in old age: Unraveling the roles of biomedical, behavioral and psychosocial factors. 7. Inger Plaisier, VU University. Graduated on November 26, Thesis: Mental health and work: studies on the role of gender, social roles and work characteristics. 8. Nicole Vogelzangs, VU University. Graduated early Thesis: Metabolic syndrome and psychosocial stress in old age. 9. Lotte Gerritsen, Utrecht University Medical Center, Will graduate on May 18, Topic: HPA-axis, depression and cognition. 10. Carmilla Licht, VU University Medical Center, Amsterdam, Topic: Autonomic nervous system and psychopathology. 11. Sophie Vreeburg, VU University Medical Center, Amsterdam, Topic: HPA-axis and psychopathology. 12. Arianne van Reedt-Dortland, Leiden University Medical Center, Topic: Metabolic syndrome and psychopathology. 13. Didi Rhebergen, VU University Medical Center, Amsterdam Topic: Dysthymia. 14. Jeroen van Zanten, VU University Medical Center, Amsterdam Topic: Geneexpression profiles among depressed patients. 15. Pierre Bet, VU University Medical Center, Amsterdam, Topic: Pharmcogenetic determinants of psychopathology. 16. Floriana Lupino, Leiden University Medical Center, Leiden, Topic: Psychiatric inpatients, metabolic syndrome and psychopathology. 17. Klaas Wardenaar, Leiden University Medical Center, Leiden, Topic: Dimensional characterization of psychopathology. 18. Julie Karsten, University Medical Centrum Groningen, Topic: Trait, state or residual state: a focus on participants with subthreshold affective problems. 19. Leonie Manthey, Leiden University Medical Center, Topic: Use of

4 Brenda W.J.H. Penninx, Ph.D page 4 benzodiazepine: prevalence and biological and genetical determinants. 20. Adrie Seldenrijk, VU University Medical Center, Amsterdam, Topic: Subclinical cardiovascular risk and depression. 21. Josine van Mill, VU University Medical Center, Amsterdam, Topic: Sleep disorders among persons with anxiety and depression. 22. Lynn Boschloo, VU University Medical Center, Amsterdam, Topic: Alcohol use disorders among persons with anxiety and depression. 23. Marc Molendijk, Leiden University, Topic: BDNF and cognition. 24. Anne-Laura van Harmelen, Leiden University, , Topic: Trauma and cognition. 25. Hester Duivis, Tilburg University, , Topic: Inflammation and depression. 26. Jacqueline Hovens, Leiden University Medical Center, Topic: Life-events and personality in depression. 27. Marloes Gerrits, VU University Medical Center, Amsterdam, Topic: Depression and somatic health in primary care. MEMBER OF THE DISSERTATION/OPPOSITION COMMITTEE 2004 Isabella Bischop, VU University; Max Stek, VU University 2005 Marleen Hermens, VU University; David Vinkers, Leiden University; Nina Kupper, Vrije University 2006 Christel Middeldorp, Vrije University; Anneke van Schaik, VU University; Marjolein Kamphuis, University Utrecht 2007 Koen van der Kooy, VU University; Wendelien Merens, Leiden University 2008 Els Licht, VU University; Miriam Knol, University Utrecht; Sannie Hamerlynck, VU University; Marijke Bremmer, VU University; Kristen Kaptein, University of Groningen Marit Tanke, University of Groningen; Jasper Nuijen, VU University; Ceren Acarturk, VU University; Jaap Peen, VU University; Maaike Verhagen, Radboud University Nijmegen; Geeske Peeters, VU University; Iris Lepolder, VU University; 2010 Neeltje Batelaan, VU University; Peter Meulenbeek, VU University; Arnoud, University Utrecht. EDITORIAL EXPERIENCE Member of the Editorial Boards of the: - Journal of Gerontology: Medical Sciences (2005 current) - European Journal of Aging (2005 current) - International Journal of Behavioral Medicine ( current) In addition, peer reviewer for many (>25) different medical journals. GRANTS Royal Netherlands Academy of Science and Arts (KNAW). Funds to hold a Genomics of gene expression conference, January Penninx/Boomsma. Total amount: 25,000 Euro. Role: Applicant. National Institute of Mental Health, National Institutes of Health. MH Project title: Integration of genomics and transcriptomics in normal twins and major depression. PI: Sullivan. Period 10/2009-9/2011. Total amount 6,5 million US Dollar. Role: Co-I Center for Medical Systems Biology (CMSB2): Multifactorial Diseases: Common Determinants, Unifying Technologies (PI: van Ommen) NWO Genomics: 0.52 million; Role: Co-PI on depression section of CMSB2. National Institute of Mental Health (NIMH), subcontract to 1R01MH (PI Sullivan, University of North Carolina). Project title: Major Depression: Stage 1 genomewide association in

5 Brenda W.J.H. Penninx, Ph.D page 5 Population-based Samples. Period: 09/ /2008. $34,048. Role: Co-PI. Stichting steun VCVGZ. De Nederlandse Studie naar Depressie bij Ouderen (NESDO). PI: Comijs. Period: ,000. Co-I. Addiction grant, ZonMW, The Netherlands. Project title: Development of alcohol use disorders: the role of clinical, psychological, environmental, genetic and neurophysiological factors. Period: 4/2008-3/ ,000. Role: PI European Network of Genetic And Genomic Epidemiology (ENGAGE), funded through the European Community s Seventh Framework Program (FP7-2007/2013), HEALTH-F Period:11/ /2010. $150,000. Role Co-I. Foundation of the National Institutes of Health, subcontract to Sulliv06GAIN0 (PI Sullivan Univerisity of North Carolina), Project title: Gain study Major Depression: Stage 1 genomewide association in Population-based Samples. Period: 1/ /2007. $28,810. Role: PI GAIN grant, foundation for National Institute of Health (fnih), USA. Project title: Major Depression: Stage 1 Genomewide Association in Population-Based Samples.Period: 10/ / genome wide association scans worth ~2 million USD. Role: co-pi (PI: Patrick Sullivan, UNC, Chapel Hill, NC). Stichting steun VCVGC. Pilot studie voor implementatie van Cognitive behavioural analysis system of psychotherapy (CBASP) voor chronische depressies. PI: Van Oppen. Period: ,000. Role: Co-I. ZonMW, program mental health (care project). Project title: The effectiveness of CBASP for chronic depression. PI: van Oppen. Period: 7/2006-6/ ,000. Role: Co-I. Netherlands Heart Foundation. Project title: Which pathways determine cardiovascular problems for patients with affective disorders? Extension of the Netherlands Study of Depression and Anxiety. PI: van Hout. Period:10/2006-9/ ,000. Role: Co-I. OOG grant, Geestkracht program, ZonMW, The Netherlands. Project title: HPA-axis dysfunction in patients with affective disorders: To whom does it concern? Candidate: Berend Verhoeff. Period: 1/ /2011. Total amount: Euro. Role: PI VIDI grant, ZonMW, the Netherlands. Project title: The pathophysiology of depression and anxiety disorders: an epidemiological examination of the roles of the HPA-axis and the autonomic nervous system. Period: 1/ /2010. Total amount: Euro. Role: PI ZonMW, program mental health (Geestkracht program). Project title: Netherlands Study of Depression and Anxiety (NESDA). Period: 12/ / ,300,000. Role: PI ZonMW, programma doelmatigheid. Development of organizational interventions to improve compliance with guidelines on depression and anxiety in primary care. PI: Verhaak. Period 5/06 4/ ,000. Role: Co-I. ZonMW, program addiction. Project title: Comorbidity of Addiction and Depression/Anxiety. PI: Beekman. Period: 12/03-12/ ,000. Role: Co-I. National Heart, Lung and Blood Institute - Institutes of Health. 1R01 HL Project title: The epidemiology of stress and the metabolic syndrome. Period: 09/ /2007. $1,027,445. Role: PI. National Institutes of Health: Claude D. Pepper Older Americans Independence Center Grant, NIH- NIA P30 AG AG PI: Pahor. Period: 10/02-09/07. $5,665,725. Role: Co-I and PI on pilot project core. Ortho Biotech Products, Project title: Fellowship grant: Training geriatric fellows in anemia research. Period: 7/2002-6/2004, $175,000. Role: PI. National Institutes of Health. Project title: ACE inhibitors and novel cardiovascular risk factors, PI: Pahor. Period: 4/02-3/05, $1,400,000. Role: Co-I National Institutes of Health, R21 AG Project title: Exercise to prevent disability and cardiovascular events, PI: Pahor. Period: 4/01-3/02, $217,125. Role: Co-I. Claude D. Pepper Center on Aging, Wake Forest University, Project title: Efficacy and

6 Brenda W.J.H. Penninx, Ph.D page 6 effectiveness of an exercise program and antidepressant medication on emotional and physical health in older persons with minor depression. Period: 7/01-6/02, $25,000. Role: PI Ortho Biotech Products, Project title: Physical health consequences of anemia in old age. Period: 1/ /2002, $101,000. Role: PI Netherlands Health Care Research Organization. Project title: Feasibility and effectiveness of a transmural psychotherapy intervention for general practice patients with late-life depression. Period: 4/2001-3/ ,000. Role: PI Dutch Sickfund Organization, Project title: (Cost)effectiveness of antidepressant drugs in general practice patients with minor depression. Period: 7/2001-6/2004, 700,000. Role: PI Netherlands Scientific Organization (NWO-CZ). Project title: Genetic and biological risk factors for cardiovascular morbidity and mortality in depressed elderly. PI: Hoogendijk. Period Role: Co-I. Brookdale Foundation, Brookdale Foundation Leadership on Aging award, Project title: The role of inflammation and health behavior in the detrimental physical health consequences of latelife depression, Period: 07/ /02, $115,000. Role: PI Women's Health Center of Excellence, Wake Forest University, Project title: The effect of an exercise program and antidepressant medication on emotional and physical health in older women with minor depression'. Period: 10/00-9/01, $12,500. Role: PI Netherlands Scientific Organization (NWO). Project title: Prognosis of major and minor depression in older primary care patients. PI: van Marwijk. Period: Role: Co-I Breedtestrategie of the VU University. An interfacultary research program funded by VU University and Ministry of Welfare, Health and Sports. Project title: Frailty and vitality in aging: an interdisciplinary approach. Period: million. Role: PI on subproject on depression. Vrije University Amsterdam. Project title: Biological frailty markers as predictors of physical health decline in older persons. Period: 10/1999-9/ ,000 euro. Role: PI (after leaving VU, Co-I) Netherlands Scientific Organization (NWO-CZ). Project title: The influence of social support and personal coping resources on phyiscal and mental functioning of elderly people with different chronic diseases. PI: Kriegsman. Period Role: Co-I. Vrije University Amsterdam, The Netherlands. Project title: Effectiveness of patient-focused, multidisciplinary care for patients with asthma and COPD. Period: 1/ / ,000. Role: PI Netherlands Scientific Organization (NWO). Project title: Effects of psychological factors on the onset and course of cardiovascular disease in the elderly. Period: 4/1998-3/ ,000. Role: PI

7 Brenda W.J.H. Penninx, Ph.D page 7 PUBLICATIONS IN PEER REVIEWED JOURNALS 1. Wardenaar KJ, van Veen T, Giltay EJ, van Veen T, Penninx BW, Zitman FG. The dimensional structure of the Inventory of Depressive Symptomatology Self Report (IDS-SR) in patients with depressive disorders and healthy controls. J Affect Dis 2010; in press. 2. Vreeburg S, Zitman FG, van der Pelt J, de Rijk RH, Verhagen JCM, van Dyck R, Hoogendijk WJG, Smit JH, Penninx BW. Anxiety disorder and HPA-axis activity: results from a large cohort study. Psychosomatic Medicine 2010; in press. 3. Rhebergen D, Beekman AT, Nolen WN, Spijker J, de Graaf R, Hoogendijk WJ, Penninx BW. Disabiilty and depression type: findings from NEMESIS. J Affect Dis 2009; in press. 4. van Beljouw I, Verhaak PFM, Prins MA, Cuijpers P, Penninx BWJH, Bensing JM. Receiving no treatment for common mental disorders: reasons and determinants. Psychiatric Services 2009; in press. 5. Prins MA, Verhaak PF, van der Meer K, Spreeuwenberg P, Smolders M, Laurant M, van Marwijk H, Penninx BW, Bensing JM. Patient factors obstructing and facilitating guidelinecompliant care for primary care patients with anxiety or depression. J Gen Int Med 2009; in press. 6. Karsten J, Hartman C, Ormel J, Nolen W, Penninx BW. Subthreshold depression based on functional impairment better defined by symptom severity than by number of DSM-IV symptoms. J Affect Dis 2009; Epub. 7. Gerritsen L, Geerlings MI, Beekman ATF, Deeg DJH, Penninx BW, Comijs HC. Childhood adversity, recent life events and salivary cortisol in older persons. Psychol Med 2009; in press. 8. Hovens JGFM, Wiersma JE, Giltay EJ, van Oppen P, Penninx BWJH, Zitman FG. Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders: The NESDA study. Acta Psychiatr Scand 2009; Epub. 9. Gerritsen L, Comijs HC, Penninx BW, Deeg DJ, Geerlings MI. Salivary cortisol, ApoE-E4 allele and cognitive decline in a prospective study of older persons. Neurobiol Aging 2009; in press. 10. Van Mill J, Hoogendijk W, Vogelzangs N, van Dyck R, Penninx BW. The association between depressive and anxiety disorders with sleep problems and duration: results from a large cohort study. J Clin Psychiatry 2009; in press. 11. Smolders AHW, Laurant MGH, Verhaak PFM, Prins MA, van Marwijk HWJ, Penninx BWJH, Wensing M, Grol RPTM. Why don t general practitioners follow clinical practice guidelines for depressive and anxiety disorders? Medical Care 2009; in press. 12. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JRB, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G,

8 Brenda W.J.H. Penninx, Ph.D page 8 Chen Y, Chines P, Clarke R, Coin LJM, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day INM, de Geus E, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen A, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PRV, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Bacquer OL, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CNA, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AFH, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurðsson G, Sijbrands EJG, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen A, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JCM, Yarnell JWG, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, DIAGRAM Consortium, GIANT Consortium, Global BPGen Consortium, Borecki IB, Loos RJF, Meneton P, Magnusson PKE, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WHL, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Hamsten A on behalf of Procardis consortium, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BWJH, Boomsma D, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin M, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC and Barroso I for the MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics 2010; in press. 13. Koster A, Van Gool CH, Kempen GI, Penninx BW, Lee JS, Rubin SM, Tylavsky F, Yaffe K, Newman AB, Harris TB, Pahor M, Ayonayon HN, van Eijk JThM, Kritchevsky SB. Late-life depressed mood and weight change contribute to the risk of each other. Am J Geriatr Psychiatry 2010; in press. 14. Glashouwer K, de Jong P, Penninx BW, Kerkhof AJ, van Dyck R, Ormel J. Do automatic self-associations relate to suicidal ideation? J Psychopathology and Behavioral Treatment 2010: in press. 15. Liu Y, Blackwood DH, Caesar S, de Geus EJC, Farmer A, Ferreira MAR, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin DY, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St. Clair D, van Dyck R, Verhage M, Wellcome Trust Case-Control Consortium, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BWJH, Purcell S, Sklar P, Sullivan P. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 2010; in press.

9 Brenda W.J.H. Penninx, Ph.D page Lamers F, Jonkers K, Bosma H, Kempen GI, Penninx BW, Knottnerus A, van Eijk JTh. Randomized controlled trial for minor to moderate major depression among older persons with COPD or diabetes. Psychother Psychosom 2010; in press. 17. Lamers F, de Jonge P, Nolen W, Zitman F, Smit JH, Beekman AT, Penninx BW. Subtypes of depression: results from NESDA. J Clin Psychiatry 2010; in press. 18. Luppino F, Bouvy P, de Wit L, Cuijpers P, Penninx BW, Zitman FG. The longitudinal association between depression and obesity: a meta-analysis. Arch Gen Psychiatry 2009; in press. 19. Antypa N, Penninx BW, van der Does W. Cognitive reactivity and suicidality: Investigation of a potentially treatable marker of suicide risk. J Affect Dis 2009; in press. 20. Gerritsen L, Comijs HC, Beekman ATF, Deeg DJH, Penninx BW, Geerlings MI. Personality and salivary cortisol in older persons. Am J Geriatr Psychiatry 2009; in press. 21. Prins MA, Verhaak PF, van der Meer K, Penninx BW, Bensing JM. Primary care patients with anxiety and depression: Need for care from the patient perspective. J Affect Dis 2009; in press. 22. Comijs HC, Gerritsen L, Penninx BW, Bremmer MA, Deeg DJ, Geerlings MI. The association between cortisol and cognitive decline in older persons. Am J Geriatric Psychiatry 2009; in press. 23. van der Veen WJ, van der Meer K, Penninx BW. Screening for depression and anxiety. Correlates of non-response and cohort attrition in the Netherlands Study of Depression and Anxiety (NESDA). Int J Meth Psychiatr Res 2009; Epub. 24. Wardenaar KJ, van Veen T, Giltay EJ, de Beurs E, Penninx BWJH, Zitman FG. Development and validation of a short version of the mood and anxiety symptoms quesionnaire: the MASQ-30. Psychiatry Res 2009; in press. 25. de Wit LM, van Straaten A, Luppino F, Penninx BW, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis. Psychiatry Res 2009; in press. 26. van Reedt-Dortland A, Giltay E, van Veen T, van Pelt J, Zitman F, Penninx BW. Associations between serum lipids and major depressive disorder: results from the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 2009, Epub. 27. Vogelzangs N, Beekman AT, Brenes G, Yaffe K, Newman AB, Harris TB, Kritchevsky SB, Penninx BW. Visceral abdominal obesity predicts occurrence of depression. J Clin Psychiatry 2009; in press. 28. Donker T, Comijs HC, Cuijpers P, Terluin B, Nolen WA, Zitman FG, Penninx BW. The validity of the Dutch K10 and extended K10 screening scale for depressive and anxiety disorders. Psychiatry Res 2009; in press. 29. Ferreira MAR, Hottenga JJ, Warrington NM, Medland SE, Willemsen G, Lawrence RW, Gordon S, de Geus EJ, Henders AK, Smit JH, Campbell MJ, Wallace L, Evans DM, Wright MJ, Nyholt DR, James AL, Beilby JP, Penninx BW, Palmer LJ, Frazer IH, Montgomery GW, Martin NG, Boomsma DI. Sequence variants in three loci influence monocyte count and erythrocyte volume. Am J Hum Genetics 2009; Nov;85(5): Benyamin B, Ferreira MA, Willemsen G, Gordon S, Middelberg RP, McEvoy BP, Hottenga JJ, Henders AK, Campbell MJ, Wallace L, Frazer IH, Heath AC, de Geus EJ, Nyholt DR, Visscher PM, Penninx BW, Boomsma DI, Martin NG, Montgomery GW, Whitfield JB. A common TPMRSS6 polymorphism (A736V) affects iron status, haemoglobin levels and

10 Brenda W.J.H. Penninx, Ph.D page 10 erythrocyte volume in the general population. Nat Genet 2009;41: Estrada K, Krawczak M, Schreiber S, van Duijn K, Stolk L, van Meurs J, Liu F, Penninx BW, Smit JH, Vogelzangs N, Hottenga JJ, Willemsen G, de Geus E, Lorentzon M, von Eller- Eberstein H, Lips P, van Schoor N, Pop V, de Keijzer J, Hofman A, Aulchenko Y, Oostra BA, Ohlsson C, Boomsma DI, Uitterlinden A, van Duijn C, Rivadeneira F, Kayser M. A genomewide association study of Northwestern Europeans involves the CNP signaling pathway in the etiology of human height variation. Hum Mol Genet 2009;18: Spinhoven P, de Rooij M, Heiser W, Smit JH, Penninx BW. The role of personality in comorbidity among anxiety and depressive disorders in primary care and specialty care: A cross-sectional analysis. Gen Hosp Psychiatry 2009;31: Smolders M, Laurant M, Verhaak P, Prins M, van Marwijk H, Penninx B, Wensing M, Grol R. Adherence to evidence-based guidelines for depression and anxiety disorders is associated with recording of the diagnosis. Gen Hosp Psychiatry 2009;31: Wiersma JE, Hovens JG, van Oppen P, Giltay EJ, van Schaik DJ, Beekman AT, Penninx BW. The importance of childhood trauma and childhood life events for chornicity of depression in adults. J Clin Psychiatry 2009;70: Vink DM, Aartsen M, Comijs HC, Heymans MW, Penninx BW, Stek ML, Deeg DJ, Beekman AT. Onset of anxiety and depression in the aging population: comparison of risk factors in a 9-year prospective study. Am J Geriatr Psychiatry 2009;17: Vogelzangs N, Beekman AT, Dik MG, Bremmer MA, Comijs H, Hoogendijk WJ, Deeg DJ, Penninx BW. Late-life depression, cortisol, and the metabolic syndrome. Am J Geriatr Psychiatry 2009;17: Vreeburg SA, Kruijtzer BP, van Pelt HJ, van Dyck R, de Rijk RH, Hoogendijk WJG, Smit JH, Zitman FG, Penninx BWJH. Associations between sociodemographic, sampling and health factors and various cortisol indicators in a large sample without psychopathology. Psychoneuroendocrinology 2009;34: Bochdanovits Z, Verhage M, Smit AB, Geus EJ, Posthuma D, Boomsma DI, Penninx BW, Hoogendijk WJ, Heutink P. Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder. Mol Psychiatry 2009;14: Licht CM, de Geus EJ, van Dyck R, Penninx BW. Association between anxiety disorders and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Psychosom Med 2009;71: Bet P, Penninx BW, Bochdanovitz Z, Uitterlinden AG, Beekman AT, van Schoor NM, Deeg DJ, Hoogendijk WJ. Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction. Am J Med Genet B Neuropsychiatr Genet. 2009;150B: Ferrarini L, Veer IM, Baerends E, van Tol MJ, Renken RJ, van der Wee NJ, Veltman DJ, Aleman A, Zitman FG, Penninx BW, van Buchem MA, Reiber JH, Rombouts SA, Milles J. Hierarchical functional modularity in the resting-state human brain. Human Brain Mapp 2009;30: Batelaan NM, de Graaf R, Penninx BW, van Balkom AJ, Vollebergh WA, Beekman AT. The 2-year prognosis of panic episodes in the general population. Psychol Med 2009;29: Pardo L, Bochdanovitz Z, de Geus E, Hottenga JJ, Sullivan P, Posthuma D, Penninx BWJH,

11 Brenda W.J.H. Penninx, Ph.D page 11 Boomsma D, Heutink P. Global similarities with local differences in linkage disequilibrium between the Dutch and HapMap CEU populations. Eur J Hum Gen 2009;17: Vreeburg SA, Hoogendijk WJ, van Pelt J, de Rijk RH, Verhagen JCM, van Dyck R, Smit JH, Zitman FG, Penninx BW. Major Depressive Disorder and Hypothalamic-pituitary-adrenal axis activity: Results from a large cohort study. Arch Gen Psychiatry 2009;66: Milaneschi Y, Corsi AM, Penninx BW, Bandinelli S, Guralnik JM, Ferrucci L. IL-1RA and incident depressive symptoms over six years in older persons: The InCHIANTI study. Biol Psychiatry 2009;65: Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Psychiatric GWAS Consortium Coordinating Committee including Penninx BW, Cichon S, Craddock N, Daly M, Faraone SV, Gejman PV, Kelsoe J, Lehner T, Levinson DF, Moran A, Sklar P, Sullivan PF. Am J Psychiatry 2009;166: Vink JM, Smit AB, de Geus EJC, Sullivan P, Willemsen G, Hottenga JJ, Smit J, Hoogendijk W, Zitman FG, Peltonen L, Kaprio J, Pedersen N, Spector T, Ohm Kyvik K, Morley KI, Heath AC, Westendorp RGJ, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW, Boomsma DI. Genome-wide association study of smoking initiation and persistence. Am J Hum Genetics 2009;84: Rhebergen D, Beekman AT, Graaf RD, Nolen WA, Spijker J, Hoogendijk WJ, Penninx BW. The three-year naturalistic course of major depressive disorder, dysthymic disorder and double depression. J Affect Dis 2009;115: Licht CM, de Geus E, Seldenrijk A, van Hout H, Zitman F, van Dyck R, Penninx BW. Depression is associated with decreased blood pressure but antidepressant use increases the risk for hypertension. Hypertension 2009;53: Sullivan P, de Geus EJC, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Dumenil T, Farmer A, Fava M, Gordon SD, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery G, Muir WJ, Nolen W, Nöthen MM, Perlis R, Pirlo K, Posthuma D, Rietschel M, Schosser A, Smoller JW, AB Smit, Tzeng JY, van Dyck R, Zitman FG, Verhage M, Martin NG, Wray NR, Boomsma DI, Penninx BW. Genome-wide association for Major Depressive Disorder: a possible role for the protein PCLO. Mol Psychiatry 2009;14: Cesari M, Kritchevsky SB. Atkinson HH, Penninx BW, Bari MD, Tracy RP, Pahor M. Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J 2009;157:334.e Yaffe K, Lindquist K, Sen S, Cauley J, Ferrell R, Penninx BW, Harris T, Li R, Cummings SR. Estrogen receptor genotype and risk of cognitive impairment in elders: Findings from the Health ABC study. Neurobiol Aging 2009;30: Penninx BW, Nicklas BJ Newman AB, Harris TB, Goodpaster BH, Satterfield S, de Rekeneire N, Yaffe K, Pahor M, Kritchevsky SB. Metabolic syndrome and physical decline in older persons: results from the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2009;64A: Cesari M, Kritchevsky SB, Newman AB, Simonsick EM, Harris TB, Penninx BWJH, Brach JS, Tylavsky FA, Satterfield S, Bauer DC, Rubin SM, Visser M, Pahor M. Added value of physical performance measures in predicting adverse health-related events. Results from the

12 Brenda W.J.H. Penninx, Ph.D page 12 Health, Aging, and Body Composition Study. J Am Geriatr Soc 2009;57: Verhaak PF, Prins MA, Spreeuwenberg P, Draisma S, van Balkom TJ, Bensing JM, Laurant MG, van Marwijk HW, van der Meer K, Penninx BW. Receiving treatment for common mental disorders. Gen Hosp Psychiatry 2009;31: De Wit LM, van Straten A, van Herten M, Penninx BW, Cuijpers P. Depression and Body Mass Index, a U-shaped association. BMC Public Health 2009, 9: YS Aulchenko, S Ripatti, I Lindqvist, DI Boomsma, I Heid, C Pattaro, BWJH Penninx, ACJW Janssens, JF Wilson, I Rudan, Å Johansson, T Spector, NG Martin, NL Pedersen, M Falchi, JJ Hottenga, F Marroni, KO Kyvik, J Kaprio, A Hofman, P Elliott, C Gieger, G Willemsen, JH Smit, A Isaacs, C Hayward, V Vitart, I Jonasson, EJG Sijbrands, N Freimer, T Meitinger, AG Uitterlinden, J Saharinen, M Perola, JCM Witteman, PP Pramstaller, MR Jarvelin, U Gyllensten, H Campbell, A Wright, N Hastie, BA Oostra, EJC de Geus, F Kronenberg, MI McCarthy, CM van Duijn, L Peltonen. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts: Nat Genet. 2009;41: Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR. Variants in MTRN1B influence fasting glucose levels. Nat Genet. 2009;41: Licht CM, de Geus EJ, Zitman FG, Hoogendijk WJ, van Dyck R, Penninx BW. Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch Gen Psychiatry 2008;65: Vogelzangs N, Kritchevsky SB, Beekman AT, Newman AB, Satterfield S, Simonsick EM, Yaffe K, Harris TB, Penninx BW. Depressive symptoms and change in abdominal obesity in older persons. Arch Gen Psychiatry 2008;65(12): de Wit MA, Tuinebreijer WC, Dekker J, Beekman AJ, Gorrissen WH, Schrier AC, Penninx BW, Komproe IH, Verhoeff AP. Depressive and anxiety disorders in different ethnic groups: A population based study among native Dutch and Turkish, Moroccan and Surinames migrants in Amsterdam. Soc Psychiatry Psychiatr Epid 2008; 43: Knipscheer K, van Schoor NM, Penninx BW, Smit JH. Levenswaardering bij ouderen; de validering van een instrument [in Dutch]. Tijdschr Gerontol Geriatr 2008;39: Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P, Cuijpers P, de Jong PJ, van Marwijk HWJ, Assendelft WJJ, van der Meer K, Verhaak P, Wensing M, de Graaf R, Hoogendijk WJ, Ormel J, van Dyck R. The Netherlands Study of Depression and Anxiety (NESDA): Rationale, objectives and methods. Int J Meth Psychiatr Res 2008;17:121-

13 Brenda W.J.H. Penninx, Ph.D page Plaisier I, de Bruijn J, Smit J, de Graaf R, Ten Have M, van Dyck R, Penninx BW. The effect of social roles on mental health: a matter of quantity or quality? J Affect Dis 2008;105: Mast BT, Miles T, Penninx BW, Yaffe K, Rosano C, Satterfield S, Ayonayon H, Harris T, Simonsick E. Vascular disease and longitudinal risk for elevated depressive symptoms in older adults: Findings from Health ABC. Biol Psychiatry 2008;15;64: Lamers F, Jonkers CC, Bosma H, Penninx BW, Knottnerus JA, van Eijk JT. Summed score of the Patient Health Questionnaire-9 was a reliable and valid method for depression screening in chronically ill elderly patients. J Clin Epidemiol. 2008;61: Wouts L, OudeVoshaar RC, Bremmer MA, Buitelaar JK, Penninx BW, Beekman AT. Cardiac disease, depressive symptoms and incident stroke in an elderly population. Arch Gen Psychiatry 2008;65: Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Lips P, Beekman AT, Penninx BW. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry 2008;65: You T, Nicklas BJ, Ding J, Penninx BW, Goodpaster BH, Bauer DC, Tylavsky FA, Harris TB, Kritchevsky SB. The Metabolic Syndrome is Associated with Circulating Adipokines in Older Adults across a Wide Range of Adiposity. J Gerontol Med Sci 2008;63: Wiersma JE, van Schaik DJ, van Oppen P, McCullough JP, Schoevers RA, Dekker JJ, Blom MB, Maas K, Smit JH, Penninx BW, Beekman AT. Treatment of chronically depressed patients: a multisite randomized controlled trial testing the effectiveness of 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP) for chronic depressions versus usual secondary care. BMC Psychiatry 2008;8: Boomsma DI, Willemsen G, Sullivan PF, Heutink P, Meijer P, Sondervan D, Kluft C, Smit G, Nolen WA, Zitman FG, Smit JH, Hoogendijk WJ, van Dyck R, de Geus EJ, Penninx BW. Genome-wide association for Major Depression: Description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. Eur J Hum Genet 2008;16: Brenes GA, Penninx BW, Judd PH, Rockwell E, Sewell DD, Wetherell JL. Anxiety, depression and disability across the lifespan. Aging Ment Health 2008;12: Bremmer MA, Beekman AT, Deeg DJ, Penninx BW, Dik MG, Hack DE, Hoogendijk WJ. Inflammatory markers in late-life depression: Results from a population-based study. J Affect Disord 2008;106: Plaisier I, de Bruijne J, Smit JH, de Graaf R, Ten Have M, Beekman AT, van Dyck R, Penninx BW. Work and family roles and the association with depressive and anxiety disorders: Differences between men and women. J Affect Disord 2008;105: Schaap LA, Pluijm SM, Deeg DJ, Penninx BW, Nicklas BJ, Lips P, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, Goodpaster BH, Tylavsky FA, Yaffe K, Visser M. Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies. Clin Endocrinol 2008;68: Koster A, Penninx BW, Newman AB, Visser M, van Gool CH, Harris TB, van Eijk JThM, Kempen GIJM, Brach JS, Simonsick EM, Houston DK, Tylavsky FA, Rubin SM, Kritchevsky SB. Lifestyle factors and incident mobility limitation in obese and non-obese older adults. Obesity 2007;15:

14 Brenda W.J.H. Penninx, Ph.D page Morsink LF, Vogelzangs N, Nicklas BJ, Beekman AT, Satterfield S, Rubin SM, Yaffe K, Simonsick E, Newman AB, Kritchevsky SB, Penninx BW. Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: Results from the Health ABC study. Psychoneuroendocrinology 2007;32: Hermens MLM, van Hout HPJ, Terluin B, Ader JH, Penninx BWJH, van Marwijk HWJ, Bosmans JE, van Dyck R, de Haan M. Clinical effectiveness of usual care with or without antidepressant medication for primary care patients with minor or mild-major depression: a randomized equivalence trial. BMC Medicine 2007;5(1): Penninx BW. Urinary Cortisol Level and Urine Volume. Am J Geriatr Psychiatry 2007;15: Dik MG, Jonker C, Comijs H, Deeg DJ, Kok A, Yaffe K, Penninx BW. The metabolic syndrome, inflammation, and cognition. Diabetes Care 2007;30: Bremmer MA, Deeg DJH, Beekman ATF, Penninx BWJH, Lips P, Hoogendijk W. Major Depression in Late Life Is Associated with Both Hypo- and Hypercortisolemia. Biol Psychiatry 2007;62: Vogelzangs N, Penninx BW. Cortisol and insulin in depression and metabolic syndrome. Psychoneuroendocrinology 2007;32: Penninx BW, Beekman AT, Bremmer M, Hoogendijk W, Bandinelli S, Lauretani F, Guralnik J, Ferrucci L. Late-Life Depressive Symptoms Are Associated With Both Hyperactivity and Hypoactivity of the Hypothalamo-Pituitary-Adrenal Axis. Am J Geriatr Psychiatry 2007;15: Maraldi C, Volpato S, Penninx BW, Yaffe K, Simonsick EM, Strotmeyer ES, Cesari M, Kritchevsky SB, Perry, S, Ayonayon HN, Pahor M. Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study. Arch Intern Med 2007;167: van Gool CH, Kempen GI, Penninx BW, Deeg DJ, van Eijk JTh. Chronic disease and lifestyle transitions: Results from the Longitudinal Aging Study Amsterdam. J Aging Health 2007;19: Vogelzangs N, Beekman AT, Kritchevsky SB, Newman AB, Pahor M, Yaffe K, Rubin SM, Harris, TB, Satterfield S, Simonsick EM, Penninx BW. Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2007;62: Penninx BW, Woodman R, Cohen HJ. Anemia and cancer in old age. J Support Oncol 2007;5: Vogelzangs N, Suthers K, Ferrucci L, Simonsick EM, Ble A, Schrager M, Bandinelli S, Lauretani F, Gianelli SV, Penninx BW. Hypercortisolemic depression is associations with the metabolic syndrome in late-life. Psychoneuroendocrinology 2007;32: Brenes GA, Kritchevsky S, Mehta K, Ayonayon H, Rosano C, Rubin S, Satterfield S, Simonsick EM, Yaffe K, Penninx BWJH. Scared to death: results from the Health, Aging and Body Composition Study. Am J Geriatr Psych 2007;15: Plaisier I, de Bruijn JGM, Smit JH, de Graaf R, ten Have M, van Dyck R, Beekman AT, Penninx BW. The contribution of working conditions and social support to the onset of affective disorders among male and female employees. Soc Sci Med 2007;64: Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx BW, Satterfield S, Harris

15 Brenda W.J.H. Penninx, Ph.D page 15 T, Cummings SR. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiol Aging 2007;28: Brenes G, Williamson J, Messier S, Rejeski J, Pahor M, Penninx BW. Treatment of minor depression in older adults: A pilot study comparison of sertraline and exercise. Aging Ment Health 2007;11: Mangani R, Cesari M, Kritchevsky SB, Maraldi C, Carter SC, Atkinson HH, Penninx BW, Marchionni N, Pahor M. Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST). Aging Clin Exp Res 2006;18: Schalk BMW, Visser M, Bremmer MM, Penninx BWJH, Bouter LM, Deeg DJH. Change of serum albumin and risk of cardiovascular disease and all-cause mortality in the Longitudinal Aging Study Amsterdam. Am J Epidemiol 2006;164: Koster A, Bosma H, Kempen GI, Penninx BW, Beekman AT, Deeg DJ, van Eijk JT. Socioeconomic differences in incident depression in older adults: The role of psychosocial factors, physical health status, and behavioral factors. J Psychosom Res 2006;61: Figaro MK, Kritchevsky SB, Resnick HE, Shorr RI, Butler J, Shintani A, Penninx BW, Simonsick EM, Goodpaster BH, Newman AB, Schwartz AV, Harris TB. Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study. Diabetes Care 2006;29: Koster A, Bosma H, Kempen G, Penninx BW, Deeg DJ, Broese-Groenou M, van Eijk JT. The explanation of socio-economic differences in changes of physical function in older adults: results from the Longitudinal Aging Study Amsterdam. BMC Public Health 2006;6(1): Hesselink AE, van der Windt DAWM, Penninx BWJH, Wijnhoven HAH, Twisk JWR, Bouter LM, van Eijk JThM. What predicts change in pulmonary function and quality of life in patients with asthma or COPD in primary care? J Asthma 2006;43: Schaik A van, van Marwijk HWJ, Ader H, van Dyck R, de Haan M, Penninx BW, van Hout H, Kooy K van der, Beekman AT. Interpersonal psychotherapy for elderly patients in primary care. Am J Geriatr Psychiatry 2006;14: Terluin B, van Marwijk HW, de Vet HC, Ader JH, Penninx BW, Hermens ML, van Balkom TJ, van der Klink JJ, Stalman WB. The four-dimensional symptom questionnaire (4DSQ): A new self-report questionnaire to assess distress, depression, anxiety and somatization. BMC Psychiatry 2006;6: Penninx BW. Response to dr. Cheng. J Am Geriatr Soc 2006;54: van Gool CH, Penninx BWJH, Kempen GIJM, Rejeski WJ, Miller GD, van Eijk JThM, Pahor M, Messier SP. Determinants of session attendance to diet and exercise interventions. Results from the Arthritis, Diet and Activity Promotion Trial. Contemp Clin Trials. 2006;27: Penninx BWJH, Pahor M, Woodman RC, Guralnik JM. Anemia in old age is associated with increased mortality and hospitalization. J Gerontol: Med Sci 2006;61: Koster A, Bosma H, Penninx BW, Kritchevsky S, Kempen GI, van Eijk JT, Krtichevsky SB. Association of inflammatory markers and socioeconomic status. J Gerontol Med Sci 2006;61: Nicklas BJ, Cesari M, Kitzman D, Penninx BW, Kritchevsky S, Newman AB, Jingzhong D, Pahor M, Harris TB. Abdominal adiposity is an independent risk factor for congestive heart failure in older men and women: The Health, Aging and Body Composition Study. J Am

16 Brenda W.J.H. Penninx, Ph.D page 16 Geriatr Soc 2006;54: Eisenstadt R, Penninx BW, Woodman R. Anemia in the elderly: Current understanding and emerging concepts. Blood Rev 2006;20: Gray SL, LaCroix AZ, Hanlon JT, Penninx BWJH, Blough DK, Leveille SG, Arts MB, Guralnik JM, Buchner DM. Benzodiazepine use and physical disability in community-dwelling older adults. J Am Geriatr Soc 2006;54: Koster A, Penninx BWJH, Bosma H, Kempen GI, Newman AB, Rubin SM, Satterfield S, Atkinson HH, Ayonayon HN, Rosano C, Yaffe K, Harris TB, Rooks RN, van Eijk JT, Kritchevsky SB. Socioeconomic differences in cognitive decline and the role of biomedical factors. Ann Epidemiol. 2005;15: Penninx BW, Pluijm S, Lips P, Woodman R, Miedema K, Guralnik JM, Deeg DJ. Anemia is associated with increased risk of recurrent falls. J Am Geriatr Soc 2005;53: Schalk BMW, Visser M, Penninx BWJH, Baadenhuijsen H, Bouter LM, Deeg DJH. Change in serum albumin and subsequent decline in functional status in older persons. Aging: Clin Exp Res 2005;17: Cesari M, Kritchevsky SB, Nicklas BJ, Penninx BWJH, Holvoet P, Koh-Banerjee P, Cummings SR, Harris TB, Newman AB, Pahor M. Lipoprotein peroxidation and mobility limitation: results from the health, aging and body composition study. Arch Intern Med 2005;165: Koster A, Penninx BWJH, Bosma H, Kempen GI, Harris TB, Newman AB, Rooks RN, Rubin SM, Simonsick EM, van Eijk JThM, Kritchevsky SB. Is there a biomedical explanation for socio-economic differences in incident mobility limitation? J Gerontol Med Sci 2005;60: Cesari M, Kritchevsky SB, Penninx BW, Nicklas BJ, Simonsick EM, Newman AB, Tylavsky FA, Brach JS, Satterfield S, Bauer DC, Visser M, Rubin SM, Harris TB, Pahor M. Prognostic value of usual gait speed in well-functioning older people. Results from the Health, Aging and Body Composition Study. J Am Geriatr Soc 2005;53: Onder G, Penninx BWJH, Cesari M, Bandinelli S, Lauretani F, Bartali B, Pahor M, Ferrucci L. Anemia is associated with depression in older adults: results from the InChianti study. J Gerontol Med Sci 2005;60: Foy CG, Penninx BWJH, Shumaker SA, Messier SP, Pahor M. Long-term exercise therapy resolves ethnic differences in baseline health status in older adults with knee osteoarthritis. J Am Geriatr Soc 2005;53: Atkinson HH, Cesari M, Kritchevsky SB, Penninx BWJH, Fried LP, Guralnik JM, Williamson JD. Predictors of combined cognitive and physical decline. J Am Geriatr Soc 2005;53: Cesari M, Kritchevsky SB, Baumgartner RN, Atkinson HH, Penninx BW, Lenchik L, Palla SL, Ambrosius WT, Tracy RP, Pahor M. Sarcopenia, obesity, and inflammation results from the Trial of Angiotension-Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am J Clin Nutr 2005;82: Kritchevsky SB, Nicklas BJ, Visser M, Simonsick EM, Newman AB, Harris TB, Lange E, Penninx BW, Goodpaster BH, Satterfield S, Colbert LH, Rubin SM, Pahor M. Angiotensinconverting enzyme insertion/deletion genotype, exercise and physical decline. JAMA 2005;294:

17 Brenda W.J.H. Penninx, Ph.D page Schalk BMW, Deeg DJH, Penninx BWJH, Bouter LM, Visser M. Serum albumin and grip strength: a longitudinal study in older men and women. J Am Geriatr Soc 2005;53: Cesari M, Penninx BWJH, Lauretani F, Russo R, Bartali B, Pahor M, Ferrucci L. Bone density and hemoglobin levels in older persons: results from the InChianti study. Osteoporosis International 2005;16: Onder G, Penninx BWJH, Ferrucci L, Fried LM, Guralnik JM, Pahor M. Measures of physical performance and risk of progressive and catastrophic disability: Results from the Women s Health and Aging Study. J Gerontol: Med Sci 2005:60: Nicklas BJ, Penninx BWJH, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB. Association of visceral adipose tissue with incident myocardial infarction in older men and women: The Health, Aging and Body Composition study. Obstet Gynecol Surv. 2005;60: van Gool CH, Penninx BWJH, Kempen GIJM, Rejesk WJi, Miller GD, van Eijk JThM, Pahor M, Messier SP. Effects of exercise adherence on physical function among overweight older adults with knee osteoarthritis. Arthritis Rheum. 2005;53: Brenes GA, Guralnik JM, Williamson J, Fried LP, Penninx BWJH. Correlates of anxiety symptoms in physically disabled older women. Am J Geriatr Psychiatr 2005;13: van Gool CH, Kempen GIJM, Penninx BWJH, Deeg DJH, Beekman ATF, van Eijk JThM. Impact of depression on disablement in late middle aged and older persons. Results from the Longitudinal Aging Study Amsterdam. Soc Sci Med 2005;60: Brenes GA, Williamson J, Guralnik JM, Fried LP, Penninx BWJH. The influence of anxiety on the development of disability. J Am Geriatr Soc 2005;53: Hesselink AE, Penninx BWJH, van der Windt DAWM, van Duin BJ, de Vries P, Twisk JW, Bouter LM, van Eijk JThM. Effectiveness of an education programme by a general practice assistant for asthma and COPD patients: results from a randomised controlled trial. Pat Educ Counsel 2004;55: Beekman ATF, Geerlings SW, Deeg DJH, Smit JH, Schroevers RA, de Beurs E, Braam AW, Penninx BWJH, van Tilburg W. Het beloop van depressie bij ouderen: resultaten van 6 jaar intensieve follow-up. Tijdschrift voor Psychiatrie 2004;46: Nicklas BJ, Penninx BWJH, Cesari M, Newman A, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB. Association of visceral adipose tissue with incident myocardial infarction in older men and women: The Health, Aging and Body Composition study. Am J Epidemiol 2004;160: Penninx BWJH, Abbas H, Ambrosius WA, Davis C, Nicklas B, Messier S, Pahor M. Markers of inflammatory markers and function among obese older persons with knee osteoarthritis. J Rheumatology 2004;31: Phelan EA, Williams B, Penninx BWJH, Lo Gerfo J, Leveille SG. ADL Function and disability in older adults in a randomized trial of the health enhancement program. J Gerontol: Med Sci 2004;59:M Penninx BWJH, Kritchevsky SB, Newman AB, Nicklas BJ, Simonsick EM, Rubin S, Nevitt M, Visser M, Harris T, Pahor M. Inflammatory markers and incident mobility limitation: Results from the Health ABC study. J Am Geriatr Soc 2004;52: Rolland Y, Cesari M, Miller ME, Penninx BWJH, Atkinson HH, Pahor M. Reliability of the 400-m usual-pace walk test as an assessment of mobility limitation in older adults. J Am

18 Brenda W.J.H. Penninx, Ph.D page 18 Geriatr Soc 2004;52: Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD: Interventions on Frailty Working Group (including Penninx BWJH). Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report. J Am Geriatr Soc 2004; 52: Penninx BWJH, Pahor M, Cesari M, Corsi AM, Woodman R, Bandinelli S, Guralnik JM, Ferrucci L. Anemia is associated with decreased physical performance and muscle strength. J Am Geriatr Soc 2004:52: Nicklas, BJ, Ambrosius W, Messier SP, Miller GD, Penninx BWJH, Loeser RF, Palla S, Bleecker E, Pahor M. Dietary-induced weight loss, exercise and chronic inflammation in older, obese adults: A randomized controlled clinical trial. Am J Clin Nutr 2004;79: Cesari M, Penninx BWJH, Lauretani F, Russo CS, Carter C, Baldinelli S, Atkinson H, Onder G, Pahor M, Ferrucci L. Hemoglobin levels and skeletal muscle: Results from the InCHIANTI Study. J Gerontol: Med Sci 2004;59:M249-M Cesari M, Penninx BWJH, Pahor M, Lauretani F, Corsi AM, Williams GR, Guralnik JM, Ferrucci L. Inflammatory markers and physical performance in older persons: the InCHIANTI Study. J Gerontol: Med Sci 2004;59:M242-M Cesari M, Pahor M, Bartali B, Cherubin A, Penninx BWJH, Williams GR, Atkinson H, Martin A, Guralnik J, Ferrucci L. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 2004:79: Hesselink AE, Penninx BWJH, Schlosser M, Wijnhoven HAH, van der Windt DAWM, van Eijk JThM. The role of coping resources and coping style in quality of life of patients with asthma and COPD. Qual Life Res 2004;13: Cesari M, Penninx BWJH, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Tracy RP, Rubin SM, Harris TB, Pahor M. Inflammatory markers and the onset of cardiovascular disease: results from the Health ABC study. Circulation 2003;108: Gray SL, Penninx BWJH, Blough DK, Artz MB, Guralnik JM, Wallace RB, Buchner DM, LaCroix AZ. Benzodiazepine use and physical performance in community-dwelling older women. J Am Geriatr Soc 2003;51: Onder G, Penninx BWJH, Guralnik JM, Jones H, Fried LP, Pahor M, Williamson J. Sexual satisfaction and risk of disability among older women. J Clin Psychiatry 2003;64: Schoevers RA, Geerlings MI, Beekman ATF, Penninx BWJH, Deeg DJH, Jonker C, van Tilburg W. De relatie tussen depressie, sekse en verhoogde mortaliteit bij thuiswonende ouderen. De AMSTEL-studie (Amsterdam Study of The Elderly). Tijdsch v Psychiatr 2003; 45: Cesari M, Penninx BWJH, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Tracy RP, Rubin SM, Harris TB, Pahor M. Inflammatory markers and cardiovascular disease: the Health, Aging and Body Composition [Health ABC] study). Am J Cardiol 2003;92: Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, Launer L, Kuller L, Rubin S, Harris T. Inflammatory markers and cognition in well-functioning African- American and white elders. Neurology 2003;61: Penninx BWJH, Guralnik J, Wallace R, Onder G, Ferrucci L, Pahor M. Anemia and physical decline in older persons. Am J Med 2003;115:

19 Brenda W.J.H. Penninx, Ph.D page Nicklas BJ, Penninx BWJH, Ryan AS, Berman DM, Lynch NA, Dennis KE. Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. Diabetes Care 2003;26: Penninx BWJH, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M. Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study. Biol Psychiatry 2003;54: Broese van Groenou MI, Deeg DJH, Penninx BWJH. Income differentials in functional disability in old age: relative risks of onset, recovery, decline, attrition and mortality. Aging Clin Exp Res 2003;15: Bisschop MI, Kriegsman DMW, van Tilburg TG, Penninx BWJH, van Eijk JThM, Deeg DJH. The influence of differing social ties on decline in physical functioning among older people with and without chronic diseases: the Longitudinal Aging Study Amsterdam. Aging Clin Exp Res 2003;15: Gool van CH, Kempen GIJM, Penninx BWJH, Deeg DJH, Beekman ATF, van Eijk THM. Relationship between changes in depressive symptoms and unhealthy lifestyles in late middle aged and older persons. Results from the Longitudinal Aging Study Amsterdam. Age and Aging 2003;32: Weeks SK, McGann P, Michaels TK, Penninx BWJH. Comparing short versions of the Geriatric Depression Scale leads to the GDS5/15. J Nursing Scholarship 2003;35: Mehta KM, Simonsick EM, Penninx BWJH, Schulz R, Rubin SM, Satterfield S, Yaffe K. Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the Health Aging and Body Composition study. JAGS 2003;51: Ferrucci L, Penninx BWJH, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, Leveille SG, Fried L, Guralnik JM. Change in muscle strength explains accelerated decline in physical function in older women with high interleukin-6 serum levels. JAGS 2002;50: Onder G, Penninx BWJH, Landi F, Atkinson H, Cesari M, Bernabei R, Pahor M. Depression and adverse drug reactions among hospitalized older adults. Arch Int Med 2003;163: Rejeski WJ, Focht BC, Messier SP, Morgan T, Pahor M, Penninx B. Obese, older adults with knee osteoarthritis: weight loss, exercise and quality of life. Health Psychology 2002: 21: Onder G, Penninx BWJH, Pahor M. ACE inhibitors use and physical performance - Authors' reply. Lancet 2002;360: Beekman ATF, Geerlings SW, Deeg DJH, Schoevers RS, de Beurs E, Braam AW, Penninx BWJH, van Tilburg W. The natural history of late-life depression: a 6-year, 14-wave prospective study in the community. Arch Gen Psychiatry 2002;59: Onder G, Penninx BWJH, Lapuerta P, Fried LP, Chaves PHM, Ostir G, Guralnik JM, Pahor M. Change in physical performance over time in older women: the Women s Health and Aging Study. J Gerontol: Med Sci 2002;57:M Beekman ATF, Penninx BWJH, Deeg DJH, de Beurs E, Geerling SW, van Tilburg W. The impact of depression on the well-being, disability and use of services in older adults: a longitudinal perspective. Acta Psychiatr Scand 2002;105: Di Bari M, Pahor M, Barnard M, Gades N, Graney M, Franse LV, Penninx BWJH, Marchionni N, Applegate WB. Evaluation and correction for a training effect in the cognitive assessment of older adults. Neuroepidemiology 2002;21:87-92.

20 Brenda W.J.H. Penninx, Ph.D page Van der Windt DAWM, Croft PR, Penninx BWJH. Neck and upper limb pain: more pain is associated with psychological distress and consultation rates in primary care. J Rheumatol 2002;29: Onder G, Penninx BWJH, Balkrishnan R, Fried LP, Chaves PHM, Williamson JD, Carter C, Di Bari M, Guralnik JM, Pahor M. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet 2002;359: Penninx BWJH, Rejeski J, Messier SP, Pandya J, Miller M, DiBari M, Applegate W, Pahor M. Exercise and depressive symptoms: A comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J Gerontol: Psych Sci 2002;57:P124-P Ferrucci LM, Furberg CA, Penninx BWJH, DiBari M, Guralnik JM, Chen JG, Applegate WB, Pahor M. Treatment of systolic hypertension in older patients: who should be treated more aggressively? Circulation 2001;104: Penninx BWJH, Messier SP, Rejeski J, Williamson JD, DiBari M, Morgan T, Applegate W, Pahor M. Physical exercise and prevention of ADL disability in older osteoarthritis patients. Arch Int Med 2001:161; Hesselink AE, Penninx BWJH, Wijnhoven HAH, Kriegsman DMW, van Eijk JThM. Determinants of incorrect inhalation technique in patients with astma and COPD. Scand J Prim Care 2001;19: Penninx BWJH, Beekman ATF, Deeg DJH. Cognitive impairment with chronic disease in depression and mortality. Reply to Dr. Gledhills letter to the editor. Arch Gen Psychiatr 2001;58: Penninx BWJH, Beekman ATF, Honig A, Deeg DJH, Schoevers RA, van Eijk JThM, van Tilburg W. Effect of depression on cardiac mortality. Results from a community-based longitudinal study. Arch Gen Psychiatr 2001;58: Rantanen T, Guralnik JM, Ferrucci L, Penninx BWJH, Leveille SG, Sipila S, Fried LP. Coimpairments as predictors of severe walking disability in older women. J Am Geriatr Soc 2001;49: Wijnhoven HAH, Kriegsman DMW, Hesselink AE, Penninx BWJH, de Haan M. Determinants of different dimensions of disease severity in asthma and COPD: pulmonary function and health-related quality of life. Chest 2001;119: Penninx BWJH, Guralnik JM, Stabler S, Ferrucci L, Fried LP. Vitamin B12 deficiency and depression: Epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry 2000;157: Leveille SG, Penninx BWJH, Melzer D, Izmirlian G, Guralnik JM. Sex differences in the prevalence of mobility disability in old age: the dynamics of incidence, recovery and mortality. J Gerontol: Soc Sci 2000;55: Rantanen T, Penninx BWJH, Masaki K, Lintunen T, Foley D, Guralnik JM. Depressed mood and body mass index as predictors of muscle strength decline in old men. J Am Geriatr Soc 2000;48: Penninx BWJH, Ferrucci L, Leveille SG, Rantanen T, Pahor M, Guralnik JM. Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol: Med Sci 2000;55:M691-M697.