NIHR CRN - Support for research available in the NHS

Transcription

1 NIHR CRN - Support for research available in the NHS Jonathan Sheffield CEO National Institute for Health Research (NIHR)

2 The NIHR The National Institute for Health Research (NIHR) is funded by the Department of Health to improve the health and wealth of the nation through clinical research. It provides a world-class infrastructure for health research and represents one of the most integrated health research systems in the world It can be considered as the research arm of the National Health Service (NHS).

3 National Institute for Health Research: An integrated health research system Invention Evaluation Adoption Early-phase clinical Research Late-phase clinical Research NIHR Biomedical Research Centres NIHR Clinical Research Facilities Experimental Cancer Medicine Centres > 0.5 billion p.a. investment in relevant infrastructure to support clinical research at all points in development pipeline Health Technology Cooperatives Diagnostic Evidence Cooperatives NIHR Collaboration for Leadership in Applied Health Research and Care

4 One National Network Research active engaged clinicians across all therapy areas Detailed understanding of patient care pathways 10,000 staff embedded in the NHS Supporting commercial and academic research Drive set up, recruitment and performance management of studies

5 Study volume Number of new studies added to the NIHR CRN Portfolio

6 Non-commercial recruitment Almost 3.5 million people recruited into all studies over the last 6 years

7 Vital Statistics - Phase Commercial contract studies undertaken during 2014 /15 by trial phase Phase I 40 Phase I/II 25 Phase II 245 Phase II/III 13 Phase III 442 Phase IV 103 Observational 212

8 Study Support Service FEASIBILITY Early Feedback Site Identification COMMERCIAL COSTING TEMPLATES National template Trust, Primary Care & Device versions HRA APPROVALS SYSTEM FOR GAINING NHS PERMISSION MODEL AGREEMENTS STUDY MANAGEMENT Collect data Performance manage studies Feasibility Set-up Delivery

9 Decreased commercial set-up Median calendar days taken to obtain NHS permission Over 82% reduction in last 5 years

10 Study delivery and management: Managing performance with quality A research-ready workforce 10,000+ GCP-trained research staff embedded in the NHS to support investigators with patient identification, recruitment, clinical delivery ICH GCP training Free to any staff working on NIHR CRN clinical trials Supported by MHRA Added to the list of GCP programs mutually recognised by TransCelerate

11 Breakthrough research Argus II study (Bionic eye) - Second Sight sponsored study In July 2015, a partially sighted 80 year old man had his central vision restored after he received a bionic eye following being recruited to a Network study World s first patient with advanced age-related macular degeneration (AMD) to receive the implant

12 Breakthrough research BOSON - a Gilead sponsored study ( ) UK took a global leadership position The second of five countries to begin enrolling patients Recruited more patients than any other country UK has the top two recruiting sites globally Gilead collaborated closely with the UK s STOP-HCV, a Hepatitis C Virus consortium, also to ensure a successful outcome

13 Benefits of Research All patients treated at research-intensive hospitals do better, not just those in trials The effect is seen for those hospitals engaged in interventional trials but not observational studies

14 Benefits of Research research done elsewhere knowledge others with trial condition research done here skills attitudes Team functions and decisions trial participants all patients treated by team

15 Networking locally to deliver globally Contact the study support team at: Tel: +44 (0) Web: