Report to UCLH Board Bryan Williams MD FRCP FESC FAHA

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1 NIHR University College London Hospitals Report to UCLH Board Bryan Williams MD FRCP FESC FAHA Professor of Medicine and BRC Director 18/03/2013

2 The NIHR UCLH BRC Renewed funding circa 100M for 5 years in April 2012; Required a refresh of research strategy; 17 themes reduced to 4 major research Programmes; Cancer, Neuroscience, 3Is (Infection, Immunity, Inflammation), Cardiometabolic; New BRC Director; 4 Programme Directors & Education/Training PD; Operations manager for each programme; BRC COO, also COO for R&D functions.

3 Changing face of the BRC New BRC Focussed on Experimental Medicine Early phase human studies CRF-based / Detailed clinical evaluation

4 Context for Change NHS Innovation for Health and Wealth Agenda; Major Government investment in UK Bioscience; Key emphasis on leverage and wealth creation; Industrial engagement Pharma, MedTech, Biotech and SMEs; Enterprise and Entrepreneurship from within; Inward investment Export Innovation Innovation in Health Care; the value proposition

5

6 Experimental Medicine and the Translational Pathway UCLH Innovation Office UCLB / TRO / UCL Enterprise Accelerate translation UCL/UCLH UCLH BRC Clinical Trials UCLP Industrial Collaboration Sir Francis Crick Institute Cross BRC/BRU Collaboration Pan-London Collaboration CHAPTER ehealth Reverse Translation Creating Health and Wealth

7 Change Process.. Realignment of UCLH BRC funding towards Experimental Medicine; Consultant PA s, Non Consultant Staff, NHS Research Support Costs Criteria for BRC support; Research in the domain of experimental medicine Research of high quality REF returnable Leverage of BRC support blue chip funding, matched funding (faculty, NHS, industry, research councils, research charities, etc.) Potential for Impact on Health and Wealth

8 BRC Budget Realignment To build Capacity and deliver a step-change in World Class Experimental Medicine Research The BRC budget review process should realign 20 million for Experimental Medicine (~ 5M per annum)

9 BRC Budget Realignment In addition to Existing Substantial BRC funding for research and infrastructure that continues to be embedded in UCLH

10 What will success look like? Expand and Accelerate Expansion of experimental medicine capability, capacity and delivery; Culture and Entrepreneurship A vibrant culture of innovation, enterprise and entrepreneurship hardwired into everything we do and recognised and rewarded; Partnership and Industry Attracting major inward investment by industry Pharma, Med-tech, Cell therapies, Diagnostics, Imaging real partnerships not simply transactional; Health and Wealth Creation Improved health care efficiency and patient outcomes from fast-tracked innovation wealth creation

11 BRC National Comparisons The most early phase human trials UCLH NIHR Analysis of Annual Reports 2011/12

12 Implications for UCLH BRC funding is now robustly performance managed against delivery of the health and wealth agenda; BRC budget needs to be strategically deployed; Cost pressure (CSR) need to be the best; Failure to deliver would be catastrophic for UCLH

13 On the Horizon.. Later Phase Clinical Trials National Reconfiguration; National NIHR Bioresource and Health Informatics initiatives ehealth agenda; Integrating and leveraging UCLP as gateway to scale.

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