A Guide to Non-Invasive Prenatal Screening

Transcription

1 verifi by Progenity A Guide to Non-Invasive Prenatal Screening

2 Prepare for life. Congratulations on your pregnancy. As an expectant mother, you have many things on your mind and you probably want to know all you can about your future family. This is where the verifi prenatal test by Progenity can help. What is the verifi prenatal test by Progenity? It is a non-invasive prenatal test that can determine with a high degree of accuracy whether your baby may have certain genetic disorders, such as Down syndrome. The test requires only a blood draw, and is safe for mother and baby. It s a simple test that can help you plan with confidence. What conditions can this test detect? The test screens for the most common chromosomal abnormalities, which can cause serious birth defects, intellectual disability, or other problems in the baby. These disorders are not typically inherited. Instead, they are usually caused by a random error during formation of the egg or sperm, or during the earliest stages of the baby s development. This test will also tell you the sex of your baby, if you want to know.

3 The verifi test by Progenity screens for: Down syndrome (Trisomy 21), which is caused by an extra copy of chromosome 21 Edwards syndrome (Trisomy 18), which is caused by an extra copy of chromosome 18 Patau syndrome (Trisomy 13), which is caused by an extra copy of chromosome 13 The test can also detect abnormalities of the sex chromosomes:* Turner syndrome (Monosomy X), which is caused by a missing X chromosome in females Klinefelter syndrome (XXY), which is caused by an extra X chromosome in males Jacobs syndrome (XYY), which is caused by an extra Y chromosome in males Triple X syndrome (XXX), which is caused by an extra X chromosome in females If your healthcare provider recommends it, the test can also screen for the following conditions, which are not routinely tested:** Trisomy 9, which is caused by an extra copy of chromosome 9 Trisomy 16, which is caused by an extra copy of chromosome 16 Common microdeletions such as DiGeorge syndrome, Angelman syndrome, Prader-Willi syndrome, Wolf-Hirschhorn syndrome and Cri-du-chat syndrome which are all caused by the loss of a small piece of a chromosome For more information about these disorders, please visit progenity.com/verifi.

4 What will the results tell me? Your results will tell you and your healthcare provider whether the genetic disorders being tested were detected in your pregnancy. If your results are normal, this means that the disorders were not detected, which can provide significant reassurance. In the case of an abnormal result, your healthcare provider will discuss what that means for your pregnancy and will offer a diagnostic procedure to confirm the result. Knowledge of a positive result can help you and your medical team plan for appropriate treatment at birth or before. It can also help you gather the appropriate medical, financial and emotional resources. Like all tests, this test has limitations. It can only detect the specific chromosomal abnormalities tested. It doesn t eliminate the possibility of all other genetic disorders, birth defects, or health conditions. Although this test is highly accurate, false negative and false positive results are possible in rare cases. When can I be tested? You can have the test at 10 weeks of pregnancy, or any time after that.

5 How does the test work? During pregnancy, some of the baby s DNA crosses the placenta into the mother s bloodstream. DNA is the blueprint of life it holds all of the genetic information needed for our bodies to function. DNA carries this genetic information on chromosomes. Healthy humans have 23 pairs of chromosomes. Any more or less can lead to problems. For this test, a sample of your blood is drawn and the DNA from you and your baby is analyzed. The test checks for chromosomal abnormalities that could affect the baby s health. Baby s DNA in mother s blood Placenta Maternal blood Fetal DNA Maternal DNA

6 For more information about the verifi test by Progenity, visit progenity.com/verifi Scan this code with your mobile phone to watch a video about non-invasive prenatal testing. Peace of Mind for Patients At Progenity, we believe all patients should have access to the highest-quality genetic tests without the burden of exorbitant medical costs. That s why we offer the Peace of Mind program, which provides payment assistance for patients who are facing financial difficulties. To discuss your options, please call us toll-free at , option S. State Road, Ann Arbor, MI Tel progenity.com Progenity is a CLIA-licensed clinical laboratory and is accredited by the College of American Pathologists (CAP). The information contained in this brochure is provided by Progenity as an educational service for physicians and their patients Progenity, Inc. All rights reserved. Progenity TM is a trademark of Progenity, Inc. verifi is a trademark of Illumina, Inc. and/or its affiliate(s) in the U.S. and other countries. REV