Paget s disease of the breast Factsheet
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1 Paget s disease of the breast Factsheet This factsheet is for people who d like more information about Paget s disease of the breast (also known as Paget s disease of the nipple). It describes what Paget s disease is, the symptoms, how a diagnosis is made and how it is treated.
2 2 Introduction We hope this information helps you to discuss any questions you may have with your specialist team. You may also find it useful to read our Treating breast cancer booklet. What is Paget s disease of the breast? Paget s disease of the breast is an uncommon type of breast cancer that usually first shows as changes to the nipple. It occurs in less than 5% of all women with breast cancer. Men can also get Paget s disease but this is very rare. Paget s disease of the breast is not connected to Paget s disease of the bone. What are the symptoms? The most common symptom is a red, scaly rash involving the nipple, which may spread to the areola (the darker skin around the nipple). The rash can feel itchy or you may have a burning sensation. The nipple may be inverted (pulled in) and there may also be discharge from the nipple. Paget s disease can look like other skin conditions such as eczema or psoriasis. But there are differences. For example, Paget s disease affects the nipple from the start while eczema generally affects the areola region and only rarely affects the nipple. Also, Paget s disease usually occurs in one breast while most other skin conditions tend to affect both breasts. About half of all people with Paget s disease will also have an underlying breast lump. In most cases this lump will be invasive breast cancer, which means it has the potential to spread to other parts of the body. Even when there is no lump, some people may still have an invasive cancer. But most people will have a non-invasive or in-situ cancer known as ductal carcinoma in situ (DCIS) somewhere in the breast. This means that the cancer cells are inside the milk ducts and have not yet developed the ability to spread either outside the ducts into the breast tissue or to other parts of the body. There are different grades of DCIS. If DCIS is left untreated, the cells may eventually develop the ability to spread and become an invasive breast cancer.
3 Visit 3 How is Paget s disease diagnosed? Because Paget s disease is rare and can look like other skin conditions, it s not always diagnosed straight away. Once your GP (local doctor) has referred you to a specialist, you may have several tests to help make the diagnosis including: a mammogram (breast x-ray) an ultrasound scan (uses high-frequency sound waves to produce an image of the breast tissue) a biopsy (removal of tissue for examination under a microscope). Biopsy You will usually have a biopsy to confirm the diagnosis. The kind of biopsy you have will depend on your symptoms. For example: a punch biopsy removes a small circle of tissue from the nipple/areola a nipple scrape removes cells from the skin of the affected nipple a core biopsy removes a small sample of tissue from the area of concern that can be felt within the breast if there is an area of cancer that cannot be felt, you may have an image guided biopsy as part of a mammogram or ultrasound scan. This can accurately locate the affected area so that a sample of tissue can be removed. These tests can be done using a local anaesthetic either in the breast clinic or in the radiology (x-ray) department for an image guided biopsy. The samples of tissue or cells are sent to the laboratory where they are looked at under a microscope. If you d like more information about tests you may be having, see our booklet Your breast clinic appointment.
4 4 What are the treatments? What are the treatments? Surgery Surgery is usually the first treatment for Paget s disease. The type of surgery will depend on the extent of the cancer within the breast. Breast-conserving surgery, also called wide local excision or lumpectomy, is the removal of the cancer with a margin (border) of normal breast tissue around it. For Paget s disease, this type of surgery also includes the removal of the nipple and areola. A mastectomy (removal of all the breast tissue including the nipple area) is usually recommended in any of the following cases: the breast cancer affects a large area of the breast it hasn t been possible to get a clear margin of normal tissue around the breast cancer using breast-conserving surgery there is more than one area of breast cancer breast-conserving surgery is not expected to provide an acceptable cosmetic result because of the position or size of the cancer. You may be offered a choice between a mastectomy and breast-conserving surgery depending on the extent of the breast cancer within the breast. Your breast surgeon will discuss this with you. If you re given a choice, it means that your specialist believes that you ll get equal benefit from either treatment, and you can choose the one you feel is best for you. If you are going to have a mastectomy, you will usually be able to have breast reconstruction. This can be done at the same time as your mastectomy (immediate reconstruction) or months or years later (delayed reconstruction). If you d like more information, see our Breast reconstruction booklet.
5 Visit 5 Lymph node removal If you have invasive breast cancer underlying the Paget s disease, your specialist team will want to check whether or not any of the lymph nodes (glands) under the arm (axilla) contain cancer cells. This helps them decide whether or not you will benefit from any additional treatment after surgery. To do this, your surgeon is likely to recommend an operation to remove either some of the lymph nodes (a lymph node sample or biopsy) or all of them (a lymph node clearance). Sentinel node biopsy is widely used for people with breast cancer whose tests before surgery show no evidence of the lymph nodes containing cancer cells. This procedure identifies whether or not the first lymph node (or nodes) is clear of cancer cells. If it is, this usually means the other nodes are clear too, so no more will need to be removed. If the results of the sentinel lymph node biopsy show that the first node (or nodes) is affected it may be recommended that you have further surgery to remove some or all of the remaining lymph nodes. Sentinel lymph node biopsy is not suitable if tests before your operation show that your lymph nodes contain cancer cells. In this case it is likely that your surgeon will recommend a lymph node clearance. Usually the lymph nodes under the arm don t need to be removed if you have DCIS. This is because the cancer cells haven t developed the ability to spread outside the ducts into the surrounding breast tissue or to other parts of the body. However, surgery to the lymph nodes may be recommended for some people with DCIS. Your specialist team will discuss this with you if this is the case. For more information, see our Treating breast cancer booklet. What are the adjuvant (additional) treatments? After surgery you may need further medical treatment. This is called adjuvant (additional) treatment and includes chemotherapy, radiotherapy, hormone (endocrine) and targeted therapies. The aim of these treatments is to reduce the risk of breast cancer cells returning in the same breast or the opposite breast, or spreading elsewhere in the body.
6 6 What are the treatments? Chemotherapy Whether chemotherapy is recommended will depend on various features of the cancer, such as its grade, size and whether the lymph nodes are affected. Chemotherapy is only used if the underlying breast cancer is invasive. It is not used to treat DCIS. If you d like more information see our Chemotherapy for breast cancer booklet. Radiotherapy If you have breast-conserving surgery for invasive breast cancer, radiotherapy will usually be recommended to reduce the risk of the breast cancer returning in the same breast. Radiotherapy will also usually be offered after breast-conserving surgery for DCIS, and your specialist will explain the benefits and possible side effects. Radiotherapy may be given to the chest wall following a mastectomy in some circumstances, for example if some of the lymph nodes under the arm are affected. For more information about radiotherapy see our Radiotherapy for primary (early) breast cancer booklet. Hormone (endocrine) therapy As the female hormone oestrogen can play a part in stimulating some breast cancers to grow, there are a number of hormone therapies that work in different ways to block the effect of oestrogen on cancer cells. Hormone therapy will only be prescribed if your breast cancer has receptors within the cell that bind to the female hormone oestrogen and stimulate the cancer to grow (known as oestrogen receptor positive or ER+ breast cancer). All breast cancers are tested for oestrogen receptors using tissue from a biopsy or after surgery. If your cancer is oestrogen receptor positive, your specialist will discuss with you which hormone therapy they think is most appropriate. When oestrogen receptors are not found (oestrogen receptor negative or ER-), tests may be done for progesterone (another female hormone) receptors. As oestrogen receptors play a more important role than
7 Visit 7 progesterone receptors, the benefits of hormone therapy are less clear for people whose breast cancer is only progesterone receptor positive (PR+ and ER-). If this is the case your specialist will discuss with you whether hormone therapy is appropriate. If your cancer is found to be hormone receptor negative, then hormone therapy will not be of any help to you. If you would like more information, please see our Treating breast cancer booklet or our individual hormone drug factsheets. Targeted therapies This is a group of drugs that block the growth and spread of cancer by interfering with the biology of the cancer cells. They target specific processes in the cells that cause cancer to grow. Targeted therapies may be more effective and less harmful to normal cells than other cancer treatments. The most well-known targeted therapy is trastuzumab (Herceptin). Trastuzumab will only help people whose cancer has high levels of HER2 (HER2 positive), a protein that makes cancer cells grow. There are various tests to measure HER2 levels, which are done on breast tissue removed during a biopsy or surgery. If your cancer is found to be HER2 negative, then trastuzumab will not be of benefit to you. For more information see our Trastuzumab (Herceptin) factsheet. For more information see our publications: Your breast clinic appointment (BCC70) Breast reconstruction (BCC7) Treating breast cancer (BCC4) Chemotherapy for breast cancer (BCC17) Radiotherapy for primary (early) breast cancer (BCC26) Trastuzumab (Herceptin) (BCC41) To order, or download a copy, please visit
8 This factsheet can be downloaded from our website, where you can also find the titles we produce as e-books. Publications are also available in large print, Braille, audio CD or DAISY format on requests by phoning This factsheet has been produced by Breast Cancer Care s clinical specialists and reviewed by healthcare professionals and people affected by breast cancer. If you would like a list of the sources we used to research this publication, publications@breastcancercare.org.uk or call Centres London and the South East of England Telephone src@breastcancercare.org.uk Wales, South West and Central England Telephone cym@breastcancercare.org.uk East Midlands and the North of England Telephone nrc@breastcancercare.org.uk Scotland and Northern Ireland Telephone sco@breastcancercare.org.uk We are able to provide our publications free of charge thanks to the generosity of our supporters. We would be grateful if you would consider making a donation today to help us continue to offer our free services to anyone who needs them. Please send your cheque/po/caf voucher to Breast Cancer Care, FREEPOST RRKZ-ARZY-YCKG, 5 13 Great Suffolk Street, London SE1 0NS Or to make a donation online using a credit or debit card, visit All rights are reserved. No part of this publication may be reproduced, stored or transmitted, in any form or by any means, without the prior permission of the publishers.
9 Breast Cancer Care is here for anyone affected by breast cancer. We bring people together, provide information and support, and campaign for improved standards of care. We use our understanding of people s experience of breast cancer and our clinical expertise in everything we do. Visit or call our free Helpline on (Text Relay 18001). Interpreters are available in any language. Calls may be monitored for training purposes. Confidentiality is maintained between callers and Breast Cancer Care. Central Office Breast Cancer Care 5 13 Great Suffolk Street London SE1 0NS Telephone Fax info@breastcancercare.org.uk Breast Cancer Care, June 2013, BCC38 Edition 5, next planned review 2015 Registered charity in England and Wales ( ) Registered charity in Scotland (SC038104) Registered company in England ( ) Printed on recycled paper please recycle
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