KLINISCHE FARMACOLOGIE - ALGEMEEN

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1 PROGRAMMA WETENSCHAPPELIJKE MEDEDELINGENDAG Maandag 2 oktober 2000 DE BLIJE WERELT, LUNTEREN KLINISCHE FARMACOLOGIE - ALGEMEEN VOORDRACHTEN uur D.A.M.C. van de Vijver, R.A.C. Roos, P.A.F. Jansen, A.J. Porsius, A. de Boer (Utrecht): Use of antidepressants in Parkinson s disease; association with disease and its course uur I. Schillevoort, E.P. van Puijenbroek, A. de Boer, R.A.C. Roos, P.A.F. Jansen, H.G.M. Leufkens (Utrecht): Extrapyramidal syndromes associated with SSRI-use uur P.M. Edelbroek, T.A.C. Vermeij, G.J.F. Brekelmans, R.M.Chr. Debets, H.H. Geesink, M.V. Rademaker (Heemstede): Therapeutic drug monitoring of antiepileptic drugs in blood spots dried on filter paper uur A.K. Teeuwisse, A.D. Lindemans, W.M.M. Verschuren, O.H. Klungel, A.J. Porsius, A. de Boer (Utrecht): Undertreatment of hypercholesterolemia in a population-based study in The Netherlands uur M.M.R. de Maat, S.V. Frankfort, R.A.A. Mathôt, J.W. Mulder, P.L. Meenhorst, E.C.M. van Gorp, J.H. Beijnen, A. de Boer, R.M.W. Hoetelmans (Amsterdam): Discrepancies between drug notations in medical records and public pharmacy records in a HIV-1-infected population: a potential for drug-drug interactions uur A.I. Veldkamp, R.P.G. van Heeswijk, J.W. Mulder, P.L. Meenhorst, G. Schreij, S. van der Geest, J.H. Beijnen, J.M.A. Lange, R.M.W. Hoetelmans (Amsterdam): The steady-state pharmacokinetics of saquinavir (SQV-SGC, Fortovase TM ) 1,000 mg bid in combination with ritonavir (RIT) 100 mg bid in HIV-1-infected individuals after a normal and a high-fat breakfast

2 uur C.A.J. Knibbe, K.P. Zuideveld, J. DeJongh, P.F.M. Kuks, L.P.H.J. Aarts, M. Danhof (Nieuwegein): Population pharmacokinetic and pharmacodynamic modelling of Propofol 6% and Propofol 1% for long term sedation in critically ill patients uur E.J. van den Berg, G.J. van der Wilt, C.F.M. Meulendijks, H. Droogleever-Fortuyn, R.J. Verkes, C. Kramers (Nijmegen): Autointoxication patients: who need to be admitted and how long should the observation period be to make this decision? uur D.J.W. van Kraaij, E.J. Vollaard, M. de Metz, A. Witterland (Maastricht): A comparison of the effects of Nabumetone versus Meloxicam on serum thromboxane B2 and platelet function uur KOFFIEPAUZE CARDIOVASCULAIRE FARMACOLOGIE VOORDRACHTEN uur W.M.C. Mulder, S. de Klerk, J.J. Settels, K.H. Wesseling, C.J. van Boxtel (Amsterdam): Clockwise hysteresis of some concentration-cardiovascular effect relationships of terbutaline in man uur M.A. van Baak, G.Hul, S. Toubro, A. Astrup, K.M. Gottesdiener, M. DeSmet, W.H.M. Saris (Maastricht): Acute thermogenic effect of L , a novel beta 3 -adrenoceptor agonist, in obese men uur J.N.J.M. de Hoon, J. Troost, L.M.A.B. van Bortel, H.A.J. Struijker-Boudier (Maastricht): Selective 5-HT 1B/1D receptor agonistinduced peripheral vascular changes in migraine patients uur F.A.A. van Acker, W.M.P.B. Menge, G.R.M.M. Haenen, A. Bast, W.J.F. van der Vijgh (Amsterdam): Frederine, a new synthetic flavonoid, is a promising protector against doxorubicin-induced cardiotoxicity uur H. Bos, R.H. Henning, P.E. de Jong, D. de Zeeuw, G.J. Navis (Groningen): Cholesterol modulates antiproteinuric response of ACEinhibition in experimental nephrosis uur C. Sand, M. Pfaffendorf, P.A. van Zwieten (Amsterdam): The pharmacological activity of therapeutics with antioxidant properties after exposure to electrolysis-induced oxidative stress uur LUNCH

3 POSTERPRESENTATIES uur T.J. Cleophas, B.M. van Ouwerkerk, J. van der Meulen, A.H. Zwinderman, R. van Marum (Dordrecht): Hypertensive patients with diabetes mellitus type II inadequately controlled by angiotensin converting enzyme inhibitors: is the combination with long-acting calcium channel blockers more effective than with beta-blockers? uur S. Gschwend, H. Buikema, Y.M. Pinto, D. de Zeeuw, M. Paul, R. Kreutz, W.H. van Gilst (Groningen): Coronary endothelial dysfunction in hypertensive rats with albuminuria uur A.C.H. Teisman, H. Buikema, D.J. van Veldhuisen, W.H. van Gilst, D. de Zeeuw (Groningen): Dietary sodium restriction improves the effects of ACE-inhibition on ventricular remodeling after myocardial infarction in rats uur J.C. Balt, M.-J. Mathy, M. Pfaffendorf, P.A. van Zwieten (Amsterdam): Blockade of pre- and postsynaptically located AT 1 - receptors; a comparison between valsartan, candesartan, eprosartan and embusartan uur POSTERBEZICHTIGING ALGEMEEN K.P. Zuideveld, P.H. van der Graaf, M. Danhof (Leiden): Allometric scaling of pharmacodynamic responses from rat to man application to the 5-HT 1A receptor mediated hypothermic response H.E. Wiersma, M. Benninga, J.J. Butter, T. Omari, C.J. van Boxtel (Amsterdam): Pharmacokinetics of baclofen in pediatric patients with gastro-oesophageal reflux disease M.A.I. Abou El Hassan, M.A. Kedde, T.H.U. Zwiers, A. Bast, W.J.F. van der Vijgh (Amsterdam): Pharmacokinetics of doxorubicin and monoher in plasma and heart tissue of mice after single and combined administration B.I. Florea, K. Kooiman, K. Derijckere, C. Meany, G. Borchard, H.E. Junginger (Leiden): Elucidation of the transport mechanism of the glucocorticoid Flunisolide in an in vitro Calu-3 cell model for the treatment of asthma J.J.H.M. Lohman (Sittard): Evidence-based guidelines for the treatment of migraine attacks using a combination of a prokinetic antiemetic and an analgesic drug J.P.T. Span, G.F.F.M. Pieters, C.G.J. Sweep, A.R.M.M. Hermus, A.G.H. Smals (Nijmegen): Gender difference in IGF1 response to growth hormone treatment in growth hormone deficient adults; role of sex hormone replacement

4 L.K. van Rossum, K. Cransberg, F. Derkx, J. Lindemans, Y.B. de Rijke, R. Zietse, A.G. Vulto (Rotterdam): The result of determination of the GFR in children by the inulin single-injection method is computer software dependent T.J. Cleophas, R. van Marum (Dordrecht): Efficacy and safety of second generation dihydropyridine calcium channel blockers in heart failure, meta-analysis FARMACOKINETIEK EN TRANSPORT VOORDRACHTEN uur L.J.J. Derijks, L.G.J.B. Engels, P.M. Hooymans, J.J.H.M. Lohman (Sittard): Pharmacokinetics of 6-mercaptopurine and azathioprine in patients with inflammatory bowel disease uur J.J. van der Wildt, C. Neef (Enschede): The pineal gland as infusion system, a pharmacokinetic approach to melatonin uur M. Verschraagen, E. Boven, R. Ruijter, M. Westerman, F.H. Hausheer, W.J.F. van der Vijgh (Amsterdam): Pharmacokinetics of (hydrated)cisplatin and (di)mesna during a phase I study of BNP7787 and cisplatin in cancer patients uur M.P. Schaddelee, D. Groenendaal, L.H. Voorwinden, A.P. IJzerman, A.G. de Boer, M. Danhof (Leiden): Blood-brain barrier transport of adenosine A 1 receptor agonists POSTERPRESENTATIES uur P-H.M. van der Kuy, F.W.H.M. Merkus, F.G.M. Russel, J.J.H.M. Lohman, P.M. Hooymans (Roermond): Pharmacokinetics of intranasal and oral hydroxocobalamin in healthy subjects uur S.A. Terlouw, P.H.H. van den Broek, F.G.M. Russel, R. Masereeuw (Nijmegen): Human colon adenocarcinoma, Caco-2, cells as a tool to study multidrug resistance protein 2-mediated drug secretion uur R. Masereeuw, A.C. Wouterse, S. Notenboom, S.A. Terlouw, F.G.M. Russel (Nijmegen): Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport deficient (TR - ) rats uur J.M.K. van Fessem, I.C.J. van der Sandt, E.C.M. de Lange, A.G. de Boer, D.D. Breimer (Leiden): Loss of integrity of the blood-brain barrier by vinblastine after inhibition of P-glycoprotein function

5 uur I.C.J. van der Sandt, R. Smolders, L. Nabulsi, K.P. Zuideveld, A.G. de Boer, D.D. Breimer (Leiden): Active transport of the 5- HT 1A receptor agonist flesinoxan by P-glycoprotein across the blood-brain barrier uur BEKENDMAKING WINNAAR NVKF&B-PROEFSCHRIFTPRIJS 2000 HUISHOUDELIJKE VERGADERING

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