Pharmacological Studies on Selected Herbs as Antidiabetic Agents

Transcription

1 Pharmacological Studies on Selected Herbs as Antidiabetic Agents A Thesis Submitted to SVKM s Narsee Monjee Institute of Management Studies (NMIMS) for the award of Degree of DOCTOR OF PHILOSOPHY IN PHARMACEUTICAL SCIENCES By Mr. Pramod Kashid Under the guidance of Dr. Anil Thaker Dr. Meena Chintamaneni SVKM s NMIMS Shobhaben Pratapbhai Patel, School of Pharmacy & Technology Management, SVKM s NMIMS, Vile Parle (W), MUMBAI

2 Statement by the Candidate This is to submit that this written submission in my thesis entitles Pharmacological Studies on Selected Herbs as Antidiabetic Agents represents my ideas in my own words and where other s ideas and words have been included, I have adequately cited and referenced the original sources. I also declare that I have stick to all principles of academic honesty and integrity and have not misrepresented or fabricated or falsified any idea/data/facts/source in my submission. I understand that any violation of above will be cause for disciplinary action by the school and can also evoke penal action from the sources which have thus not been properly cited or from whom proper permission has not been taken when needed. Patent related to API, process, product, method and equipment have been examined to ensure non-infringing approach to existing patents. This thesis encompasses the information generated by me based on experimental work carried out in the institute/industry. I assure and hold full responsibility for its genuineness Pramod S. Kashid Forwarded Through Guides: Prof. Anil Thaker Professor of Pharmaceutical Chemistry, Ambarnath Organics Pvt. Ltd Prof. Meena Chintamaneni Associate Dean SPP School of Pharmacy & Technology Management, SVKM s NMIMS, Vile Parle (W), Mumbai

3 Certificate The work described in this thesis entitled Pharmacological Studies on Selected Herbs as Antidiabetic Agents has been carried out by Mr. Pramod Kashid under our supervision. We certify that this is his bonafide work. The work described is original and has not been submitted for any degree to this or any other university. Date: Place: Mumbai Guides: Prof. Anil Thaker Department of Pharmaceutical Chemistry, Prof. Meena Chintamaneni Associate Dean Prof. V. Addepalli Head, Department of Pharmacology Dean Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM s NMIMS, Vile Parle (W), Mumbai

4 Approval Sheet This thesis entitled Pharmacological Studies on Selected Herbs as Antidiabetic Agents by Mr. Pramod Kashid is approved for the degree of Doctor of Philosophy Examiners Supervisor s Chairman Date: Place:

5 A C K N O W L E D G E M E N T It is indeed an honour and proud privilege for me to acknowledge with profound gratitude my research supervisor Prof. Anil Thaker and Meena Chintamaneni who stood beside me during every moment of my work. It was on account on of guidance and expertise of guide that an idea took the shape of a wonderful research project. In this short span I have gained the much needed diversified knowledge. It therefore enhances my pleasure in thanking my research supervisor s Prof. Anil Thaker and Meena Chintamaneni. It gives me great pleasure to thank Prof. R.S. Gaud, Dean, SPP School of Pharmacy and Technology Management, NMIMS University for ensuring that all the facilities were available for smooth functioning of my research work. I owe my deepest gratitude towards management of Trident Clinical Research Pvt. Ltd that they supported me in a number of ways, their encouragement, guidance and support, help and suggestions at every juncture of this work which spurred on me in the pursuit of my work with immense enthusiasm, leaving no room for diversion or discouragements which would restrain my interest in the research work. I specially thank Dr. Bala Prabhakar, Dr. Kala Kulkarni, Dr. R. K. Goyal, Dr. V. Addepalli, Dr. Kirshnapriya Mohanraj and Dr. Sanjeevani Ghone for their guidance and support throughout my research work. I am thankful to Dr. Yogesh Kulkarni and Dr. Santosh Yele for their timely help throughout my research work. I offer my sincere appreciation to all the faculty members of SPPSPTM, NMIMS University for the valuable support they extended to me during the tenure of my research work. I take this opportunity to acknowledge the support and help by Dr. D.P. Chaudhari, Haffkine Institute Mumbai for Histopathological studies. My special thank s to Mr. Ataali Shaikh for guidance and supporting me during my thesis submission phase. I am indebted to Mr. Shirish Telsang, Atul Wagle, Mehul Desai, Gayatri Ranade, Shyam Gosavi, Hemant Mote, Bharat Narnavar, Sachin Patil, Sunil Kulkarni, Dr. Pravin Shende and many of my colleagues and friends who supported me during my research work.

6 I am grateful to Mrs. Indrayani Gaikwad, Mrs. Mansi Talegaokar, Mrs. Jaee patil, Ms.Sony, Ms. Harsha, Ms. Pinki & Mr. Mangesh, administrative staff of the school for their timely help and support. How can I forget to mention Onkar Sawant, Sagar Patil, Manhar Yamgar, Shwta Pitre and Priya Ganpathy and Mr. Umesh. It was their timely help which made the tiring preclinical work look so easy. I run short of words to express my deep regards to my parents, brother, sister and my wife for their moral support, inspiration, love and understanding, which has made this work possible. It was because of them that I could under take this difficult task. It is my duty to express tearful acknowledgement to the experimental animals which Sacrificed their lives and patients tested for the study drug for just the benefit of humanity. Pramod Suresh Kashid