Approaching Pancytopenia
|
|
- Pauline Natalie Riley
- 7 years ago
- Views:
Transcription
1 Approaching Pancytopenia Lisa Sproat MD, MSW American College of Osteopathic Internists Annual Convention MFMER slide-1
2 Objectives Understand work up of Pancytopenia Present differential diagnosis of Pancytopenia Recognize Not Miss causes of Pancytopenia 2012 MFMER slide-2
3 2012 MFMER slide-3
4 Most common indication for bone marrow biopsy 2012 MFMER slide-4
5 H&P Fever URI symptoms LAD Hepato or splenomegaly B symptoms Travel history Prescribed, non-prescribed and herbal medications ETOH Environmental and chemical exposure history Sexual history 2012 MFMER slide-5
6 Most Common Cause Chemotherapy 2012 MFMER slide-6
7 Congenital Bone Marrow Failure Syndromes Fanconi Anemia (Mitomycin C or Diepoxybutane test) Dyskeratosis Congenita (genetic testing) Shwachman-Diamond Syndrome (genetic testing, sweat chloride test normal) Congenital Amegakaryocytic Thrombocytopenia (genetic testing, elevated thrombopoietin level) Hemophagocytic Lymphohistiocytosis (hemophagocytosis, hypertriglyceridemia, hypofibrinogenemia, low/absent NK cell activity, elevated serum ferritin, soluble CD25>2,400 U/ml 2012 MFMER slide-7
8 Paroxysmal Nocturnal Hemoglobinuria Hemolysis Pancytopenia Venous Thrombosis Flow Cytometry for PNH: CD CD55 and MFMER slide-8
9 Peripheral Destruction of Hematopoietic Cells Hemophagocytosis Prosthetic valves Splenomegaly Drugs Infection 2012 MFMER slide-9
10 Sequestration Splenomegaly 2012 MFMER slide-10
11 Acquired Bone Marrow Failure Syndromes Most often what is seen in adult population 2012 MFMER slide-11
12 Chemotherapy 2012 MFMER slide-12
13 Radiation 2012 MFMER slide-13
14 Autoimmune Disorders Aplastic Anemia Idiopathic (if not caused by drugs, chemicals,radiation,virus, anorexia, pregnancy) Distinguish from hypoplastic MDS (cytogenetics and FISH) 2012 MFMER slide-14
15 The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia Elizabeth P. Weinzierl, MD, PhD and Daniel A. Arber, MD American Journal of Clinical Pathology, 2013; 139, MFMER slide-15
16 Autoimmune Disorders Systemic Lupus Erythematosus Any other autoimmune disorder (or the treatment for it) 2012 MFMER slide-16
17 Marrow Space Occupying Lesions Heme malignancy MDS/MPD Leukemia Lymphoma Multiple Myeloma Metastatic malignancy Granulomatous disease 2012 MFMER slide-17
18 Infection Viral Fungal Bacterial 2012 MFMER slide-18
19 The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia Elizabeth P. Weinzierl, MD, PhD and Daniel A. Arber, MD American Journal of Clinical Pathology, 2013; 139, MFMER slide-19
20 Hemophagocytosis Must have 5 of the following Fever Splenomegaly Cytopenia involving 2 or more cell lines Hypertriglyceridemia or hypofibrinogenemia Hepatitis Low or absent NK cell activity Histiocyte activation 2012 MFMER slide-20
21 Ineffective Marrow Production Drugs ETOH Infiltration Deficiencies 2012 MFMER slide-21
22 Malignancy Any Lung and Breast most common non heme malignancy 2012 MFMER slide-22
23 Drugs Most common cause for aplastic anemia 2012 MFMER slide-23
24 The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia Elizabeth P. Weinzierl, MD, PhD and Daniel A. Arber, MD American Journal of Clinical Pathology, 2013; 139, Shimamura A, Guinan E. Acquired and inherited aplastic anemia syndromes. In: Greer J, Foerster J, Lukens Jet al. Wintrobe s Clinical Hematology. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; MFMER slide-24
25 Nutritional Deficiencies Copper Folate B12 Anorexia Nervosa 2012 MFMER slide-25
26 The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia Elizabeth P. Weinzierl, MD, PhD and Daniel A. Arber, MD American Journal of Clinical Pathology, 2013; 139, MFMER slide-26
27 The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia Elizabeth P. Weinzierl, MD, PhD and Daniel A. Arber, MD American Journal of Clinical Pathology, 2013; 139, MFMER slide-27
28 Work up H&P Fever URI symptoms LAD Hepato or splenomegaly B symptoms Travel history Prescribed, non-prescribed and herbal medications ETOH Environmental and chemical exposure history Sexual history CBC Diff MCV Review of peripheral smear blasts Bone Marrow Biopsy Aspirate and Core Flow Cytometry Cytogenetics FISH PCR *Talk to your pathologist 2012 MFMER slide-28
29 Not Miss MDS Distinguish from AA Leukemia Early treatment has better outcomes for the non elderly population HIV I have been fooled! ETOH I have been fooled! 2012 MFMER slide-29
30 Take Home Points H and P will lead you Listen to your patients but check for HIV and watch for ETOH withdrawal Don t miss Leukemia (AML or ALL) Bone Marrow Biopsy Talk to the pathologist 2012 MFMER slide-30
31 Thank You!!!! Lisa Sproat MD, MSW 2012 MFMER slide-31
Introduction. About 10,500 new cases of acute myelogenous leukemia are diagnosed each
Introduction 1.1 Introduction: About 10,500 new cases of acute myelogenous leukemia are diagnosed each year in the United States (Hope et al., 2003). Acute myelogenous leukemia has several names, including
More informationCord blood Banking Transplant List for One USA Bank - StemCyte www.stemcyte.com/cordblood-banking-transplant-list
Cells4Life is the oldest and largest cord blood storage company in the UK. We are governed by some of the world's most stringent medical laws, and are currently the only stem cell storage company in the
More informationCorporate Medical Policy Genetic Testing for Fanconi Anemia
Corporate Medical Policy Genetic Testing for Fanconi Anemia File Name: Origination: Last CAP Review: Next CAP Review: Last Review: genetic_testing_for_fanconi_anemia 03/2015 3/2016 3/2017 3/2016 Description
More informationinformation for payers and referrers
a d u lt s t e m c e l l t r a n s p l a n tat i o n p r o g r a m information for payers and referrers Spring 2014 For more information, visit www.dfbwcc.org/bmt. o u r expertise Since its founding in
More informationACUTE MYELOID LEUKEMIA (AML),
1 ACUTE MYELOID LEUKEMIA (AML), ALSO KNOWN AS ACUTE MYELOGENOUS LEUKEMIA WHAT IS CANCER? The body is made up of hundreds of millions of living cells. Normal body cells grow, divide, and die in an orderly
More informationCollect and label sample according to standard protocols. Gently invert tube 8-10 times immediately after draw. DO NOT SHAKE. Do not centrifuge.
Complete Blood Count CPT Code: CBC with Differential: 85025 CBC without Differential: 85027 Order Code: CBC with Differential: C915 Includes: White blood cell, Red blood cell, Hematocrit, Hemoglobin, MCV,
More informationMalignant Lymphomas and Plasma Cell Myeloma
Malignant Lymphomas and Plasma Cell Myeloma Dr. Bruce F. Burns Dept. of Pathology and Lab Medicine Overview definitions - lymphoma lymphoproliferative disorder plasma cell myeloma pathogenesis - translocations
More informationLYMPHOMA. BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons
LYMPHOMA BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons Normal development of lymphocytes Lymphocyte proliferation and differentiation:
More informationLaboratory Studies in the Diagnosis of Iron Deficiency, Latent Iron Deficiency and Iron Deficient Erythropoiesis
Laboratory Studies in the Diagnosis of Iron Deficiency, Latent Iron Deficiency and Iron Deficient Erythropoiesis General Comments The laboratory studies listed below are helpful in the diagnosis and management
More informationCord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD
Cord Blood Banking Scott N. Furlan, MD Ellen S.Plummer, MD Overview Background Biology of Stem Cell Transplant Opportunities i at Parkland Logistics of Banking Potential Barriers Indications for HCT Cancer
More informationMULTIPLE MYELOMA 1 PLASMA CELL DISORDERS Multiple l Myeloma Monoclonal Gammopathy of Undetermined Significance (MGUS) Smoldering Multiple Myeloma (SMM) Solitary Plasmacytoma Waldenstrom s Macroglobulinemia
More informationBONE MARROW FAILURE DISEASE SYMPOSIUM SATURDAY SEPTEMBER 27, 2014 AN UPDATE ON THE LATEST IN DIAGNOSIS AND TREATMENT
SATURDAY SEPTEMBER 27, 2014 THE HOTEL HERSHEY 100 Hotel Road, Hershey, PA 17033 BONE MARROW FAILURE DISEASE SYMPOSIUM AN UPDATE ON THE LATEST IN DIAGNOSIS AND TREATMENT A CONTINUING EDUCATION SERVICE OF
More informationSpecific Standards of Accreditation for Residency Programs in Pediatric Hematology/Oncology
Specific Standards of Accreditation for Residency Programs in Pediatric Hematology/Oncology INTRODUCTION 2009 A university wishing to have an accredited program in Pediatric Hematology/Oncology must also
More informationStem Cell Transplantation
Harmony Behavioral Health, Inc. Harmony Behavioral Health of Florida, Inc. Harmony Health Plan of Illinois, Inc. HealthEase of Florida, Inc. Ohana Health Plan, a plan offered by WellCare Health Insurance
More informationimmunologic-- immunophenotypes are found by monoclonal antibodies - B-progenitor cells T-progenitor cells, mature B cells
Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Childhood ALL was the first form of cancer shown to be curable with chemotherapy and irradiation. Lymphoid leukemias
More informationAn overview of CLL care and treatment. Dr Dean Smith Haematology Consultant City Hospital Nottingham
An overview of CLL care and treatment Dr Dean Smith Haematology Consultant City Hospital Nottingham What is CLL? CLL (Chronic Lymphocytic Leukaemia) is a type of cancer in which the bone marrow makes too
More informationwww.assureimmune.com
Stem Cell Bank Cord Blood Important facts for when you re expecting www.assureimmune.com Banking your baby s umbilical cord blood could be a potentially lifesaving decision. There s a brief moment of opportunity
More informationSaving lives globally through mutual miracles. LifeCord is a public non-profit cord blood bank licensed by the FDA.
Saving lives globally through mutual miracles LifeCord is a public non-profit cord blood bank licensed by the FDA. Donating your baby s cord to a public cord blood bank can save lives globally. You can
More informationSTEM CELLS : A THERAPEUTIC REVOLUTION JACQUES KADOCH ROBERT HEMMINGS MARINELA MANDRA
STEM CELLS : A THERAPEUTIC REVOLUTION JACQUES KADOCH ROBERT HEMMINGS MARINELA MANDRA OVO CLINIC I 8000 BLVD DECARIE, MONTREAL QC H4P 2S4 I 514.798.2000 I OVOCLINIC.COM 2 a therapeutic revolution As the
More informationAcute myeloid leukemia (AML)
Acute myeloid leukemia (AML) Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. Adult
More informationChronic Lymphocytic Leukemia. Case Study. AAIM Triennial October 2012 Susan Sokoloski, M.D.
Chronic Lymphocytic Leukemia AAIM Triennial October 2012 Susan Sokoloski, M.D. Case Study 57 year old male, trial application for $1,000,000 Universal Life coverage Cover letter from sales agent indicates
More informationAcute Myeloid Leukemia
Acute Myeloid Leukemia Introduction Leukemia is cancer of the white blood cells. The increased number of these cells leads to overcrowding of healthy blood cells. As a result, the healthy cells are not
More informationchronic leukemia lymphoma myeloma differentiated 14 September 1999 Pre- Transformed Ig Surface Surface Secreted Myeloma Major malignant counterpart
Disease Usual phenotype acute leukemia precursor chronic leukemia lymphoma myeloma differentiated Pre- B-cell B-cell Transformed B-cell Plasma cell Ig Surface Surface Secreted Major malignant counterpart
More informationGRANIX (tbo-filgrastim)
RATIONALE FOR INCLUSION IN PA PROGRAM Background Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophils. A person with severe neutropenia has an absolute neutrophil
More informationTalking With Your Doctor About Multiple Myeloma: A guide to making the most of your healthcare visits
There s a lot to think about and many important decisions to make when you or someone you care for has multiple myeloma. It s important to have an ongoing conversation with your healthcare team throughout
More informationBrain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them.
Brain Cancer Introduction Brain tumors are not rare. Thousands of people are diagnosed every year with tumors of the brain and the rest of the nervous system. The diagnosis and treatment of brain tumors
More informationEvaluation of a Child with Elevated Transaminases. Linda V. Muir, M.D. April 11, 2008 Northwest Pediatric Liver Disease Symposium
Evaluation of a Child with Elevated Transaminases Linda V. Muir, M.D. April 11, 2008 Northwest Pediatric Liver Disease Symposium Disclosures I do not have a financial interest, arrangement or affiliation
More informationTechnical University of Mombasa Faculty of Applied and Health Sciences
Technical University of Mombasa Faculty of Applied and Health Sciences DEPARTMENT OF MEDICAL SCIENCES UNIVERSITY EXAMINATION FOR THE DEGREE OF BACHELOR OF MEDICAL LABORATORY SCIENCES BMLS 12S Mid AML 4321
More informationCytogenetics for the Rest of Us: A Primer
Cytogenetics for the Rest of Us: A Primer James J. Stark, MD, FACP Medical Director Cancer Program Maryview Medical Center Diane Maia, M.D. Pathologist, Bon Secours Hampton Roads Case #1 78 y.o. lady seen
More informationThings You Don t Want to Miss in Multiple Myeloma
Things You Don t Want to Miss in Multiple Myeloma Sreenivasa Chandana, MD, PhD Attending Hematologist and Medical Oncologist West Michigan Cancer Center Assistant Professor, Western Michigan University
More informationPathology No: SHS-CASE No. Date of Procedure: Client Name Address
TEL #: (650) 725-5604 FAX #: (650) 725-7409 Med. Rec. No.: Date of Procedure: Sex: A ge: Date Received: Date of Birth: Account No.: Physician(s): Client Name Address SPECIMEN SUBMITTED: LEFT PIC BONE MARROW,
More informationLiving with PNH: Understanding the treatment options for paroxysmal nocturnal hemoglobinuria
Living with PNH: Understanding the treatment options for paroxysmal nocturnal hemoglobinuria If you ve been diagnosed with PNH, treated for bone marrow disorders or told you have anemia, you should read
More informationWhy discuss CLL? Common: 40% of US leukaemia. approx 100 pa in SJH / MWHB 3 inpatients in SJH at any time
Why discuss CLL? Common: 40% of US leukaemia approx 100 pa in SJH / MWHB 3 inpatients in SJH at any time Median age of dx is 65 (30s. Incurable, survival 2-202 20 years Require ongoing supportive care
More informationYoung fetus: site of hematopoiesis together with the liver and bone marrow. Hgb WBC >----------< Plt Hct. Retic =
Learning Objectives At the completion of this program, the participants will be able to: 1. Identify the components of the CBC and Differential and their clinical implications. 2. Identify normal pediatric
More informationCareers in Haematology
Careers in Haematology A Guide for Medical Students and Junior Doctors Haematology is the medical speciality concerned with blood disorders. Your non-medical friends however will always think that you
More informationHAEMATOLOGY LABORATORY
HAEMATOLOGY LABORATORY Head of Unit : Dr Raudhawati Osman Phone : +603-26155281 Email : raudhaosman@yahoo.com 1. INTRODUCTION The Haematology Unit, Department of Pathology, HKL provides tertiary diagnostic
More informationInteresting Case Series. Periorbital Richter Syndrome
Interesting Case Series Periorbital Richter Syndrome MarkGorman,MRCS,MSc, a Julia Ruston, MRCS, b and Sarath Vennam, BMBS a a Division of Plastic Surgery, Royal Devon and Exeter Hospital, Exeter, Devon,
More informationMULTIPLE MYELOMA Review & Update for Primary Care. Dr. Joseph Mignone 21st Century Oncology
MULTIPLE MYELOMA Review & Update for Primary Care Dr. Joseph Mignone 21st Century Oncology OVERVIEW Identify the diagnostic criteria for multiple myeloma Compare first & second line therapies, using data
More informationSWOG ONCOLOGY RESEARCH PROFESSIONAL (ORP) MANUAL VOLUME I RESPONSE ASSESSMENT LEUKEMIA CHAPTER 11A REVISED: OCTOBER 2015
LEUKEMIA Response in Acute Myeloid Leukemia (AML) Response criteria in Acute Myeloid Leukemia for SWOG protocols is based on the review article Diagnosis and management of acute myeloid leukemia in adults:
More informationMEDICAL COVERAGE POLICY
Important note Even though this policy may indicate that a particular service or supply is considered covered, this conclusion is not necessarily based upon the terms of your particular benefit plan. Each
More informationIRON METABOLISM DISORDERS
IRON METABOLISM DISORDERS ANEMIA Definition Decrease in the number of circulating red blood cells Most common hematologic disorder by Most common hematologic disorder by far 1 Blood loss ANEMIA Causes
More informationNot All Stem Cells are the Same
Cord Blood Banking and Transplantation Jennifer Willert, M.D. Hematology/Oncology Blood and Marrow Transplant Rady Children s Hospital San Diego Clinical Professor UCSD Not All Stem Cells are the Same
More informationNATIONAL CANCER INSTITUTE. Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma
NATIONAL CANCER INSTITUTE Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma Basic Trial Information Phase Type Status Age Sponsor Protocol IDs Phase
More informationWhat is a Stem Cell Transplantation?
What is a Stem Cell Transplantation? Guest Expert: Stuart, MD Associate Professor, Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with Drs. Ed and Ken. I am
More informationDiseases Treated by Blood Stem Cells
Diseases Treated by Blood Stem Cells This is the only website to group hematopoietic (blood) stem cell treatments according to whether they are standard, in trial, or experimental. (Courtesy of Parents
More informationNOW OFFERING. FamilyCord.com
Experience a lifetime of security NOW OFFERING FamilyCord.com Dear Expectant Parent, Congratulations on the upcoming birth of your baby. As a physician and father, I know how important it is to protect
More informationAdult Medical-Surgical Nursing H A E M A T O L O G Y M O D U L E : L E U K A E M I A 2
Adult Medical-Surgical Nursing H A E M A T O L O G Y M O D U L E : L E U K A E M I A 2 Leukaemia: Description A group of malignant disorders affecting: White blood cells (lymphocytes or leucocytes) Bone
More informationClinical Course and Flow Cytometric Analysis of Paroxysmal Nocturnal Hemoglobinuria in the United States and Japan
Clinical Course and Flow Cytometric Analysis of Paroxysmal Nocturnal Hemoglobinuria in the United States and Japan Jun-Ichi Nishimura, MD, PhD, Yuzuru Kanakura, MD, PhD, Russell E. Ware, MD, PhD, Tsutomu
More informationEstimated New Cases of Leukemia, Lymphoma, Myeloma 2014
ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the
More informationINTRODUCTION Thrombophilia deep vein thrombosis DVT pulmonary embolism PE inherited thrombophilia
INTRODUCTION Thrombophilia (Hypercoagulability) is a condition in which a person forms blood clots more than normal. Blood clots may occur in the arms or legs (e.g., deep vein thrombosis DVT), the lungs
More information亞 東 紀 念 醫 院 Follicular Lymphoma 臨 床 指 引
前 言 : 惡 性 淋 巴 瘤 ( 或 簡 稱 淋 巴 癌 ) 乃 由 體 內 淋 巴 系 統 包 括 淋 巴 細 胞 淋 巴 管 淋 巴 腺 及 一 些 淋 巴 器 官 或 組 織 如 脾 臟 胸 腺 及 扁 桃 腺 等 所 長 出 的 惡 性 腫 瘤 依 腫 瘤 病 理 組 織 型 態 的 不 同 可 分 為 何 杰 金 氏 淋 巴 瘤 (Hodgkin s disease) 與 非 何 杰 金
More informationInteresting Case Review. Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA
Interesting Case Review Renuka Agrawal, MD Dept. of Pathology City of Hope National Medical Center Duarte, CA History 63 y/o male with h/o CLL for 10 years Presents with worsening renal function and hypercalcemia
More informationBone Marrow Evaluation for Lymphoma. Faizi Ali, MD Hematopathology Fellow William Beaumont Hospital
Bone Marrow Evaluation for Lymphoma Faizi Ali, MD Hematopathology Fellow William Beaumont Hospital Indications One of the most common indications for a bone marrow biopsy is to evaluate for malignant lymphoma.
More informationChildhood Cancer in the Primary Care Setting
Childhood Cancer in the Primary Care Setting Mohamed Radhi, M.D. Associate Professor, UMKC Pediatric Hematology/Oncology/BMT Children s Mercy Hospital I will discuss: Overview of childhood cancer Presentation
More informationPROTOCOLS FOR TREATMENT OF MALIGNANT LYMPHOMA
2012 1 31,, PROTOCOLS FOR TREATMENT OF MALIGNANT LYMPHOMA Version 1.0 2012 DIVISION OF HAEMATOLOGY / ONCOLOGY DEPARTMENT OF MEDICINE KAOHSING VETERAN GENERAL HOSPTIAL General Guide Diagnosis 1.Adequate
More informationYour Cord Blood Donation Options
Your Cord Blood Donation Options Our Mission To develop and maintain a statewide resource for potentially life-saving cord blood to treat children and adults. What is cord blood? Cord blood is the blood
More informationwww.lifesouthcord.org
www.lifesouthcord.org www.lifesouth.org (888) 795-2707 LifeCord Gainesville, FL www.lifesouthcord.org John Wingard. M.D. LifeCord Medical Director Price Eminent Scholar and Professor of Medicine Deputy
More informationWaldenström Macroglobulinemia: The Burning Questions. IWMF Ed Forum May 18 2014 Morie Gertz MD, MACP
Waldenström Macroglobulinemia: The Burning Questions IWMF Ed Forum May 18 2014 Morie Gertz MD, MACP Are my kids going to get this? Familial seen in approximately 5 10% of all CLL patients and can be associated
More informationPreoperative Laboratory and Diagnostic Studies
Preoperative Laboratory and Diagnostic Studies Preoperative Labratorey and Diagnostic Studies The concept of standardized testing in all presurgical patients regardless of age or medical condition is no
More informationFastTest. You ve read the book... ... now test yourself
FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. Please refer back to relevant sections
More informationOncology Best Practice Documentation
Oncology Best Practice Documentation Click on the desired Diagnoses link or press Enter to view all information. Diagnoses: Solid Tumors Lymphomas Leukemias Myelodysplastic Syndrome Pathology Findings
More informationNEW YORK STATE CYTOHEMATOLOGY PROFICIENCY TESTING PROGRAM Glass Slide Critique ~ November 2010
NEW YORK STATE CYTOHEMATOLOGY PROFICIENCY TESTING PROGRAM Glass Slide Critique ~ November 2010 Slide 081 Available data: 72 year-old female Diagnosis: MDS to AML WBC 51.0 x 10 9 /L RBC 3.39 x 10 12 /L
More informationMy Sister s s Keeper. Science Background Talk
My Sister s s Keeper Science Background Talk Outline Acute promyelocytic leukemia (APL) APL Treatment Savior Siblings In vitro fertilization (IVF) Pre-implantation Genetic Diagnosis (PGD) Risks of donating
More informationStem Cell Transplantation In Patients with Fanconi Anemia
Stem Cell Transplantation In Patients with Fanconi Anemia FARF Annual Family Meeting 6/28/15 Casco, ME Parinda A. Mehta, M.D. Cincinnati Children s Hospital Medical Center Improvements in Unrelated Donor
More informationMultiple Myeloma. This reference summary will help you understand multiple myeloma and its treatment options.
Multiple Myeloma Introduction Multiple myeloma is a type of cancer that affects white blood cells. Each year, thousands of people find out that they have multiple myeloma. This reference summary will help
More informationLeukemias and Lymphomas: A primer
Leukemias and Lymphomas: A primer Normal blood contains circulating white blood cells, red blood cells and platelets 700 red cells (oxygen) 1 white cell Neutrophils (60%) bacterial infection Lymphocytes
More informationSubtypes of AML follow branches of myeloid development, making the FAB classificaoon relaovely simple to understand.
1 2 3 4 The FAB assigns a cut off of 30% blasts to define AML and relies predominantly on morphology and cytochemical stains (MPO, Sudan Black, and NSE which will be discussed later). Subtypes of AML follow
More informationYour Cord Blood Donation Options
Your Cord Blood Donation Options What is cord blood? Cord blood is the blood that remains in the placenta after a baby is born. Cord blood has been found to be a rich source of stem cells and can be used
More informationLEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials
LEUKEMIA LYMPHOMA MYELOMA Advances in Clinical Trials OUR FOCUS ABOUT emerging treatments Presentation for: Judith E. Karp, MD Advancements for Acute Myelogenous Leukemia Supported by an unrestricted educational
More informationAcute Myelogenous Leukemia Pre-HSCT Data
Instructions for Acute Myelogenous Leukemia Pre-HSCT Data (Form 2010) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the AML Pre-HSCT Data Form. E-mail
More informationCOLONIAL LIFE & ACCIDENT INSURANCE COMPANY P.O. Box 1365, Columbia, South Carolina 29202 1-800-325-4368
COLONIAL LIFE & ACCIDENT INSURANCE COMPANY P.O. Box 1365, Columbia, South Carolina 29202 1-800-325-4368 SPECIFIED DISEASE COVERAGE OUTLINE OF COVERAGE (Applicable to Policy Form C1000-PA-R) THIS POLICY
More informationMean Platelet Volume (MPV) in Thrombocytopenia
ORIGINAL ARTICLE Mean Platelet Volume (MPV) in Thrombocytopenia R Sridhar Reddy 1, Manjiri Dilip Phansalkar 2, PVB Ramalakshmi 3 1 Assistant Professor of Pathology, Rajiv Gandhi Institute of Medical Sciences
More informationCHAPTER 2. Neoplasms (C00-D49) March 2014. 2014 MVP Health Care, Inc.
Neoplasms (C00-D49) March 2014 2014 MVP Health Care, Inc. CHAPTER SPECIFIC CATEGORY CODE BLOCKS C00-C14 Malignant neoplasms of lip, oral cavity and pharynx C15-C26 Malignant neoplasms of digestive organs
More informationSummary of the risk management plan (RMP) for Accofil (filgrastim)
EMA/475472/2014 Summary of the risk management plan (RMP) for Accofil (filgrastim) This is a summary of the risk management plan (RMP) for Accofil, which details the measures to be taken in order to ensure
More informationCanadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents
Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents Eileen Quinlan Collection Supervisor, Brampton (GTA) 2015-11-10 History One Match Stem Cell and Marrow
More informationNarrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood
[Track 2: What Is a Transplant?] Narrator: Transplants using stem cells from the blood, bone marrow or umbilical cord blood can be an effective treatment for people with blood cancers such as leukemia,
More informationElevated Serum Lactate Dehydrogenase Values in Children with Multiorgan Involvements and Severe Febrile Illness
Iranian Journal of Pediatrics Society Volume 1, Number 1, 2007: 31-35 Original Article Elevated Serum Lactate Dehydrogenase Values in Children with Multiorgan Involvements and Severe Febrile Illness Farah
More informationCord Blood Stem Cell Transplantation
LEUKEMIA LYMPHOMA MYELOMA FACTS Cord Blood Stem Cell Transplantation No. 2 in a series providing the latest information on blood cancers Highlights Umbilical cord blood, like bone marrow and peripheral
More informationAn Introduction to the Improved FDA Prescription Drug Labeling
An Introduction to the Improved FDA Prescription Drug Labeling 1 Introduction Mary E. Kremzner, Pharm.D. CDR, U.S. Public Health Service Deputy Director, Division of Drug Information Center for Drug Evaluation
More informationStem Cell Transplantation and the Canadian First Nations Community. Becky Luk (PTLS) Tanya Petraszko, MD
Stem Cell Transplantation and the Canadian First Nations Community Becky Luk (PTLS) Tanya Petraszko, MD Why is there a need for stem cells? Our Story Why are we engaging the First Nations, Metis and Inuit
More informationPT CordLife Indonesia Premium Cordblood Bank. PT CordLife Indonesia Premium Cordblood Bank
Cordblood Stem Cells and The Role of Cordblood Bank in Supporting Stem Cells Research Presentation Overview Company profile Haematopoietic stem cells in cordblood What we can do to help 1 2 PT CordLife
More information2011 Update on the ECIL-3 guidelines for EBV management in patients with leukemia and other hematological disorders
UPDATE ECIL-4 2011 2011 Update on the ECIL-3 guidelines for EBV management in patients with leukemia and other hematological disorders Jan Styczynski, Hermann Einsele, Rafael de la Camara, Catherine Cordonnier,
More informationAPPENDIX B SAMPLE INFORMED CONSENT FORM
APPENDIX B SAMPLE INFORMED CONSENT FORM B.1 INFORMED CONSENT TO PARTICIPATE IN A RESEARCH STUDY Umbilical Cord Blood Banking for Transplantation You are being asked to take part in a research study that
More informationWhat we will discuss today
Umbilical cord blood banking It s Utility? Dr. Nita Radhakrishnan Pediatric Hematology Oncology Unit, Sir Ganga Ram Hospital, New Delhi What we will discuss today What are stem cells? What are the sources
More informationCancer 1000 Level 2 Benefit Chart and Outline of Coverage
Cancer 1000 Level 2 Benefit Chart and Outline of Coverage We will pay benefits if certain routine cancer screening tests are performed or if cancer is diagnosed after the waiting period and while your
More informationGeneral Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014
General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention
More informationEmerging New Prognostic Scoring Systems in Myelodysplastic Syndromes 2012
Emerging New Prognostic Scoring Systems in Myelodysplastic Syndromes 2012 Arjan A. van de Loosdrecht, MD, PhD Department of Hematology VU University Medical Center VU-Institute of Cancer and Immunology
More informationICD-10 CM/PCS Tip Sheets. Oncology
ICD-10 CM/PCS Tip Sheets Oncology About This Guide This collection of tip sheets has been developed by Cape Fear Valley Health to promote greater specificity of the coded data for a given condition, disease,
More informationEasy Bruising and Bleeding in the Adult Patient: A Sign of Underlying Disease
Review of Clinical Signs Series Editor: Bernard M. Karnath, MD Easy Bruising and Bleeding in the Adult Patient: A Sign of Underlying Disease Bernard M. Karnath, MD Achief complaint of easy bruising and
More informationPLATELETS: OVERVIEW. J. Kelton, M.D. May 3 rd, 2003
PLATELETS: OVERVIEW J. Kelton, M.D. May 3 rd, 2003 HEMOSTASIS: A system to control blood loss from spontaneous or traumatic breaks in the blood vessel. THROMBOSIS: The formation of a blood clot within
More informationRole of Transfusion Medicine Consultant in Peripheral Blood Stem Cell Transplant Program
Role of Transfusion Medicine Consultant in Peripheral Blood Stem Cell Transplant Program Dr Anita Tendulkar MD(Path),DPB,DIT Associate Professor Transfusion Medicine Tata Memorial Hospital Advanced Centre
More informationOncology. Objectives. Cancer Nomenclature. Cancer is a disease of the cell Cancer develops when certain cells begin to grow out of control
Oncology Objectives Describe the etiology and pathophysiological mechanisms of cancer Discuss medical and family history findings relevant to cancer Identify general signs and symptoms associated with
More informationCOLONIAL LIFE & ACCIDENT INSURANCE COMPANY P.O. Box 1365, Columbia, South Carolina 29202 1-800-325-4368
COLONIAL LIFE & ACCIDENT INSURANCE COMPANY P.O. Box 1365, Columbia, South Carolina 29202 1-800-325-4368 SPECIFIED DISEASE COVERAGE OUTLINE OF COVERAGE (Applicable to Policy Form C1000-CA) 'THIS POLICY
More informationLung Cancer. This reference summary will help you better understand lung cancer and the treatment options that are available.
Lung Cancer Introduction Lung cancer is the number one cancer killer of men and women. Over 165,000 people die of lung cancer every year in the United States. Most cases of lung cancer are related to cigarette
More informationProteins. Protein Trivia. Optimizing electrophoresis
Proteins ELECTROPHORESIS Separation of a charged particle in an electric field Michael A. Pesce, Ph.D Department of Pathology New York-Presbyterian Hospital Columbia University Medical Center Rate of migration
More informationLCD for Viral Hepatitis Serology Tests
LCD for Viral Hepatitis Serology Tests Applicable CPT Code(s): 86692 Antibody; Hepatitis, Delta Agent 86704 Hepatitis B Core Antibody (HBcAb); Total 86705 Hepatitis B Core Antibody (HBcAb); IgM Antibody
More informationMultiple Myeloma Patient s Booklet
1E Kent Ridge Road NUHS Tower Block, Level 7 Singapore 119228 Email : ncis@nuhs.edu.sg Website : www.ncis.com.sg LIKE US ON FACEBOOK www.facebook.com/ nationaluniversitycancerinstitutesingapore Multiple
More informationInterpretation of Laboratory Values
Interpretation of Laboratory Values Konrad J. Dias PT, DPT, CCS Overview Electrolyte imbalances Renal Function Tests Complete Blood Count Coagulation Profile Fluid imbalance Sodium Electrolyte Imbalances
More informationChapter 4 Section 23.1. High Dose Chemotherapy (HDC) And Stem Cell Transplantation
Surgery Chapter 4 Section 23.1 High Dose Chemotherapy (HDC) And Stem Cell Transplantation Issue Date: November 1, 1983 Authority: 32 CFR 199.4(e)(5) and (g)(15) 1.0 CPT 1 PROCEDURE CODES 38205, 38207,
More information