The Danish Biobank System a unique resource for biomedical research and development
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1 The Danish Biobank System a unique resource for biomedical research and development Professor Stephen Hamilton-Dutoit Chair of Pathology, Aarhus University Denmark
2 Denmark a great little country for biobank research Population = 5.7 million
3 What is a Biobank? An organized collection of human biological material The associated data, stored in a readily analysable format
4 Why are Biobanks Useful? Biobanks hold the key to: Unravel the molecular basis of disease subtypes and enable precision medicine Understand gene-environmental/lifestyle interactions Develop biomarkers Identify new targets for therapy Boost development in drug discovery
5 Clinical Medicine = Precision Medicine Precision medicine an approach to disease treatment and prevention based on individual variability in genes, environment, and lifestyle for each person.
6 Precision Medicine
7 Translational clinical research Precision Medicine - the hunt for BIOMARKERS!
8 Every era has transformative events! 1850s: The birth of modern cancer histopathology
9 Every era has transformative events! Since 2000: New ways to hunt for biomarkers of disease
10 Biobanks are hot!
11 Using Biobanks for Drug Discovery and Develoment Zatloukal & Hainaut 2010
12 The Basis for Precision Medicine Biospecimens Molecular analysis Electronic medical records Clinical knowledge Linked health data DENMARK!
13 Health Data Research the Danish Model The world s most valuable epidemiological research infrastructure Unique system of registers and clinical databases Enormous financial investment in registers Now coordination of biobanks The key is the CPR-number system
14 The Danish Registers Neonatal history Clinical history Specific disease register National Danish Pathology Databank Disease Screening Other laboratory tests Vaccination history Social, school and education Prescription database Clinical Quality databases
15 The Danish Registers Neonatal history Clinical history Specific disease register National Danish Pathology Databank CPRnumber Disease Screening Other laboratory tests Vaccination history Social, school and education Prescription database Clinical Quality databases
16 The Danish Registers Neonatal history Clinical history Specific disease register National Danish Pathology Databank CPRnumber Disease Screening Other laboratory tests Vaccination history Social, school and education Prescription database Clinical Quality databases
17 The Danish Registers Health data from cradle to grave and beyond the grave Danish biobanks can follow disease over generations
18 The Danish Biobanks Danish National Biobank Danish Cancer Society biobanks Danish National Birth Cohort biobank Danish Phenylketouria Cards (blood from all Danes since 1976 The National Danish Cancer Biobank Danish Pathology Bank (approx. 25 million tissue samples) Disease specific biobanks Local hospital and research project biobanks
19 Danish Biobanks state of the art facilities
20 Danish Biobanks state of the art facilities
21 Danish Biobanks - Organization
22 BIOBANKS Danish Biobank Register NATIONAL REGISTERS DK Cancer Society Hospital Biobanks Civil Registration System Danish National Patient Registry Danish Family Relations Database Pathology Bank Danish Medical Birth Registry National Biobank DK Cancer Biobank ONLINE ACCESS BIOBANK REGISTER National Danish Pathology Registry
23 Accessing Data and Specimens in the Danish Biobanks In principle, data and specimens are freely accessible Easy online access Modest retrieval costs Necessary permissions Danish Data Protection Agency Ethical Board approval
24 Accessing Data and Specimens in the Danish Biobanks See the video of how to do it here! biobankdenmark.dk Register
25 The Danish National Biobank
26 Danish Guthrie (PKU) Card Biobank Blood cards from all Danes since 1976 (ca. 2 million)
27 The National Danish Cancer Biobank National, population based cancer biobank Collect blood, cells, tissues, molecules From all Danish cancer patients at first diagnosis 6 University-based centres Departments of Pathology Departments of Biochemistry
28 The National Danish Cancer Biobank
29 The National Danish Cancer Biobank Local and Regional Biospecimen collection Biospecimen storage Online data registration
30 The National Danish Cancer Biobank Local and Regional Biospecimen collection Biospecimen storage Online data registration National Administration Data management
31 Specimens in the National Danish Cancer Biobank
32 Specimens in the National Danish Cancer Biobank Blood Tissue Molecules mirna DNA RNA
33 The National Danish Cancer Biobank - Local Organization Department of Oncology Obtains patient consent Blood sample
34 The National Danish Cancer Biobank - Local Organization Department of Oncology Obtains patient consent Blood sample Blood specimen taken Cancer biopsy or operation
35 The National Danish Cancer Biobank - Local Organization Department of Biochemistry Blood preparation & storage Department of Pathology Tissue selection & storage
36 The National Danish Cancer Biobank - Local Organization Department of Biochemistry Blood preparation & storage Department of Pathology Tissue selection & storage
37 Paraffin Block Archive, Institute of Pathology Aarhus University Hospital Part of Denmark s largest biobank! Routine diagnostic specimens from ca Stored indefinitely Millions of paraffin blocks A treasure chest for researchers
38 The National Danish Pathology Data- and Tissue Bank National database Paraffin block archives stored at 19 pathology departments
39 Danish National Pathology Registry Developed routine diagnostic for Danish pathologists Real-time updating of all pathology analyses performed throughout Denmark > 14 million biospecimens Complete from 1997 some data back to 1960s CPR ID-number based Available for researchers Unique in the world
40 Danish National Pathology Registry CPR-number based Enables powerful molecular epidemiological studies We can find >90% of paraffin blocks for 30 year-old cohorts Blocks suitable for molecular studies Good for: Biomarker discovery and validation Cheap, efficient retrospective drug studies (phase 3 & 4)
41 What can we do using the Danish National Pathology Registry?
42 HOLYDAN: HOdgkin LYmphoma in DANmark AIM Study the molecular profile and viral association of ALL cases of Hodgkin Lymphoma diagnosed in Denmark
43 HOLYDAN: HOdgkin LYmphoma in DANmark DK Pathology Bank Civil Reg. System CPR DK Cancer Register DK Haematology Database DK Cause of Death Register
44 HOLYDAN: HOdgkin LYmphoma in DANmark DK Pathology Bank Database-linkage via CPR (ID) number Civil Reg. System CPR DK Cancer Register DK Haematology Database DK Cause of Death Register
45 HOLYDAN: HOdgkin LYmphoma in DANmark Civil Reg. System DK Haematology Database DK Pathology Bank CPR DK Cause of Death Register DK Cancer Register Database-linkage via CPR (ID) number 2520 cases diagnosed as chl identified ( ) 2432 cases biopsied Review - 52 not chl Paraffin block retrieved in 2237 cases (94% success rate)
46 HOLYDAN: HOdgkin LYmphoma in DANmark ON-GOING in >2200 cases! Protein studies TMAs &immunohistochemistry proteomics DNA studies GWAS RNA & mirna Gene expression profiling (NanoString)
47 The Danish Biobanking System - has the key components for success
48 Japanese inspired garden in Aarhus, Denmark
49 有難う御座います Tak!
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