Portable Oxygen Concentrator Comparisons TECHNOLOGY 8/11

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1 Portable Oxygen Concentrator Comparisons TECHNOLOGY

2 All oxygen conserving technologies are not created equal. This book will help you understand the differences in conserving technologies and point out the advantages of EasyPulse POC. There are significant differences in how oxygen conserving systems function and perform. What is most important is how well they saturate the patient s blood oxygen level without inhibiting ambulation. The ability of a conserving technology to sense, react and deliver oxygen within the first half of the patient s inspiration is directly related to its clinical benefit and efficiency. 2

3 Theory & Operation Section 1 TECHNOLOGY

4 Continuous Oxygen Administration Useful O2 O2 Wasted Flow 0 Pooling Patient Flow Dead Space O2 Flow Exhale Inhale Exhale Typical Patient Breath 4

5 Calculation of F I O 2 2L/min = 33 ml/s (2000 ml/60s) 17 ml of 100% oxygen form the anatomic reservoir (0.5 s end-expiratory pause x 33 ml s) 17 ml of 100% oxygen during inspiration (0.5 s Ti-Tdead x 33 ml s) 316 ml of 21% oxygen (room air) = 66 ml of 100% oxygen = 100 ml 100% oxygen F I O 2 = 100 ml oxygen/350 ml V T useful = 28% 5

6 Continuous Oxygen Administration 100% Oxygen Flow Rate F I O 2 ( 0 / 0 ) 1 L/min 24 2 L/min 28 3 L/min 32 4 L/min 36 5 L/min 40 6 L/min 44 F I O 2 = fraction of inspired oxygen. 6

7 Pulse Volume: Peak Flow: Nasal Pressure: Trigger Delay Time: Trigger Sensitivity: Pulse Delivery Time: Minute Volume: Terms & Definitions This is the size of the pulse (bolus) of oxygen the conserving technology delivers to the patient on each breath. The maximum (highest) flow achieved during the delivery of oxygen. The monitored pressure in the patient s nasal cavity while connected via a nasal cannula. The response time (delay) of a conserving technology from the onset of patient inhalation to start the of the oxygen delivery. The level of negative pressure (inspiratory effort) required to activate a conserving technology to deliver the oxygen. The elapsed time from the start of oxygen flow to the end of oxygen flow resulting in the delivery of the pulse. Total amount of oxygen delivered to the patient over a minute s time, calculated by multiplying breath rate by the pulse volume. 7

8 SLPMPulse Delivery with Minute Volume Control TECHNOLOGY EasyPulse POC ml Pulse STP Volume 19 ml STP EasyPulse POC slpm Peak Flow 8.7 slpm 10 Patient Nasal Pressure C Time (seconds) Nasal Pressure Pulse Volume/Flow Patient Breath EasyPulse 5 Setting Breath Rate of 20 bpm 0.36 cm H2O 2.0 MH2ODelivers a high peak flow during the first 33% (or 1/3) of the Inspiratory Phase with minimal trigger delay. The pulse (bolus) volume varies with patient breath rate. Over time the sum of the boluses (controlled minute volume) will be consistent. 8

9 Precision Medical s Controlled Minute Volume ( ) Technology Controlled Minute Volume ( ) technology utilizes a pulse waveform algorithm, superior trigger sensitivity and fast delivery time. All this is accomplished with a single lumen cannula. technology is the most efficient, reliable and clinically sound available today. Continuous flow oxygen therapy which in itself is a minute volume dose has been the gold standard since oxygen was first prescribed for patient use. is the only conserving technology that mimics continuous flow oxygen therapy, pneumatically or electronically. technology achieves this by delivering a consistent amount of oxygen per minute regardless of patient breath rate. delivers a true pulse of oxygen upon each breath within the first 1/3 of inhalation. The volume of the pulse automatically adjusts to the patient s breath rate, maintaining minute volume. The patented technology is available only from Precision Medical, Inc. The benefits for the provider and patient are: Predictable use time Excellent patient saturation Reduced operation costs Easy to use Efficient oxygen delivery Durable and reliable Single lumen cannula 9

10 Precision Medical s Conserving Technology Performance Characteristics Pulse Volume: Peak Flow: Trigger Delay Time: Trigger Sensitivity: Pulse Delivery Time: Minute Volume: Delivered every breath; it s volume is dependent on breath rate and pulse setting. (See product charts for specific volumes) Between 6 and 11 lpm depending on breath rate and pulse setting. Between 75 and 85 milliseconds depending on breath rate and pulse setting. Between and cm H 2 O negative pressure depending on breath rate and pulse setting. Between 0.15 and 0.35 seconds depending breath rate and pulse setting. Consistent between 15 and 35 breaths per minute. (See product charts for specific volumes) 10

11 Performance & Comparison Section 2 TECHNOLOGY

12 General Performance Specifications Dimensions Height 10.1 (25.7 cm) Width Depth 6.5 (16.5 cm) 4.4 (11.4 cm) Weight Device only 6.78 lbs. (3.08 kg) Operating Temperature Range in Carry Bag Extra Battery 7.29 lbs. (3.31 kg) 1.23 lbs. (0.56 kg) F (5-40 C) Altitude Sea Level to 9000 ft (2743 m) Sound Level 44 dba (at Setting 2) Power Requirements VAC ( VAC) VDC ( VDC) Battery Duration Setting: Hrs. O2 Concentration 87% To 95% Trigger Sensitivity Trigger Delay Hrs Hrs Hrs Hrs Seconds Typical 0.11 Seconds Typical 12

13 Pulse Volumes & Delivered Minute Volumes Setting Pulse Breath Rate of: Minute Volume ml 12ml 10ml 8ml 240ml/min 2 25ml 19ml 15ml 13ml 380ml/min 3 35ml 26ml 21ml 17ml 520ml/min 4 44ml 33ml 26ml 22ml 660ml/min 5 52ml 39ml 31ml 26ml 780ml/min Minute Volume BPM 13

14 SLPM2 lpm Continuous Flow vs at 20 Breaths per Minute 2 lpm, 1st 1 / 2 of Insp. Volume 17 2 lpm Continuous Peak Flow 2 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm Patient Nasal Pressure.36 cm H 2 O FiO 2 95 % C Patient s Nasal Pressure EasyPulse POC LPM Continuous Flow Trigger Delay Setting Breath Rate of 20 bpm 1st ½ of Inspiration 2nd ½ of Inspiration Start of Exhalation Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow 2 lpm Cont. EasyPulse POC MH2O14

15 SLPM2 lpm Continuous Flow vs at 30 Breaths per Minute 2 lpm, 1st 1 / 2 of Insp. Volume 11 2 lpm Continuous Peak Flow 2 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm 10 Patient Nasal Pressure.36 cm H 2 O 9 Start of Exhalation Inspiration Inspiration C1.0 7 Patient s Nasal Pressure EasyPulse POC LPM Continuous Flow Trigger Delay Setting Breath Rate of 30 bpm 1st ½ of Time (seconds) FiO 2 95 % 2nd ½ of Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow 2 lpm Cont. EasyPulse POC MH2O15

16 SLPMInogen One G2 vs Inogen One Pulse Volume 15 Inogen One Peak Flow 6.4 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm Inogen One O 2 Purity 96 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 20 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow Inogen One EasyPulse POC MH2O16

17 SLPMInogen One G2 vs Inogen One Pulse Volume 10 Inogen One Peak Flow 6.5 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm Inogen One O 2 Purity 96 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 30 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow Inogen One EasyPulse POC MH2O17

18 SLPMInvacare XPO2 vs XPO2 Pulse Volume 18 XPO2 Peak Flow 9.0 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm XPO2 O 2 Purity 91 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 20 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow XPO2 EasyPulse POC MH2O18

19 SLPMInvacare XPO2 vs XPO2 Pulse Volume 12 XPO2 Peak Flow 8.8 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm XPO2 O 2 Purity 91 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 30 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow XPO2 EasyPulse POC MH2O19

20 SLPMLife Choice vs Life Choice Pulse Volume 20 Life Choice Peak Flow 4.1 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm Life Choice O 2 Purity 82 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 20 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow Life Choice EasyPulse POC MH2O20

21 SLPMLife Choice vs Life Choice Pulse Volume 20 Life Choice Peak Flow 3.8 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm Life Choice O 2 Purity 68 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 30 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow Life Choice EasyPulse POC MH2O21

22 SLPMPhillips/Respironics EverGo vs EverGo Pulse Volume 16 EverGo Peak Flow 6.7 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm EverGo O 2 Purity 95 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 20 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow EverGo EasyPulse POC MH2O22

23 SLPMPhillips/Respironics EverGo vs EverGo Pulse Volume 16 EverGo Peak Flow 7.3 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm EverGo O 2 Purity 94 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 30 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow EverGo EasyPulse POC MH2O23

24 SLPMAirSep FreeStyle vs FreeStyle Pulse Volume 18 FreeStyle Peak Flow 4.7 ml STP slpm EasyPulse POC Pulse Volume 19 ml STP EasyPulse POC Peak Flow 8.7 slpm FreeStyle O 2 Purity 95 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 20 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow FreeStyle EasyPulse POC MH2O24

25 SLPMAirSep FreeStyle vs FreeStyle Pulse Volume 11 FreeStyle Peak Flow 4.4 ml STP slpm EasyPulse POC Pulse Volume 13 ml STP EasyPulse POC Peak Flow 8.1 slpm FreeStyle O 2 Purity 95 % EasyPulse POC O 2 Purity 95 % C Setting Breath Rate of 30 bpm Time (seconds) Nasal Pressure Patient Breath 2.0 Pulse Volume/Flow FreeStyle EasyPulse POC MH2O25

26 800 PHYSICAL SIZE COMPAIRSON Cubic Inches FreeStyle 249 Life Choice XPO2 396 Inogen One G2 EverGo 26

27 WEIGHT COMPAIRSON lbs FreeStyle 5.00 Life Choice XPO2 Inogen One G2 EverGo 27

28 Performance Comparison 20 PBM Model Device Manufacture Se=ng Minute Date se=ng 5 FreeStyle June %/9ml 95%/18ml 95%/20ml n/a n/a 95% Life Choice Oct %/10ml 82%/20ml 62%/30ml n/a n/a 68% EasyPulsePOC May %/13ml 955/19ML 94%/26ML 94%/33ML 94%/39ML 94% XPO2 June %/12ml 91%/18ml 90%/30ml 86%/30ml 84%/35ml 85% Inogen One G2 June %/7ml 96%/15ml 96%/24ml 95%/33ml 93%/41ml 93% EverGo June %/7ml 95%/16ml 94%/24ml 94%/33ml 94%/37ml 94% 30 PBM Model Device Manufacture Se=ng Minute Date se=ng 5 Free Style June %/6ml 95%/11ml 95%/13ml n/a n/a 95% Life Choice Oct %/10ml^ 68%/20ml^ 52%/30ml^ n/a n/a 52%^ EasyPulsePOC May %/8ml 95%/13ml 94%/17ml 94%/22ml 94%/26ml 94% XPO2 June %/9ml 91%/12ml 89%/16ml 88%/20ml 78%/22ml 78% Inogen One G2 June %/5ml 95%/10ml 95%/16ml 95%/22ml 94%/27ml* 94% EverGo June %/7ml 94%/16ml 94%/23ml 94%/23ml 94%/23ml 94% 27 BPM, device could not sustain 30 BPM * Device did not trigger on every breath 28