46 Shoulder Pain ANATOMY AND FUNCTION SCOTT DAVID MARTIN THOMAS S. THORNHILL KEY POINTS

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1 46 Shoulder Pain SCOTT DAVID MARTIN THOMAS S. THORNHILL KEY POINTS Comprehension of functional anatomy allows diagnosis of most causes of shoulder pain on clinical examination. History and clinical examination aided by ancillary tests will usually guide application of the most appropriate treatment for shoulder pain. The differential diagnosis of shoulder pain includes not only common local disorders (e.g., of tendon and adjacent structures) but should also include consideration of etiologies arising from distant anatomic sites arising by referred pain-mediated pathways. A variety of specific diagnostic tests can greatly aid in diagnosis of shoulder pain. Most causes of shoulder pain can be treated with a structured physical therapy program. Successful treatment programs understand potential surgical candidates including those who fail conservative treatment. Systemic arthroopathies can occasionally present with shoulder disease and often involve the shoulder over time. Early assessment in such patients is essential. Shoulder pain is one of the most common musculoskeletal complaints that may arise from diverse causes. Accurate diagnosis of shoulder pain is made difficult by the unique anatomy and position of the shoulder, which serves as a link between the upper extremity and the thorax. One of the most complex and mobile joints of the body, the shoulder is traversed by muscle, tendon, and bone, and is surrounded by major neurovascular structures, all of which may serve as potential sources of local and referred pain. Determining the source of shoulder pain is essential in recommending the proper method of treatment. The examining physician must be able to differentiate the occurrence of shoulder pain caused by intrinsic, or local factors, and extrinsic, or remote factors, or a combination of the two. Intrinsic factors originate from the shoulder girdle and include glenohumeral and periarticular disorders, whereas extrinsic factors occur outside of the shoulder girdle with secondary referral of pain to the shoulder (Table 46-1). Examples of extrinsic factors include left shoulder pain as the initial presentation of coronary artery disease; hepatic, gallbladder, and splenic disease also may initially manifest as shoulder pain. Accurate evaluation, diagnosis, and treatment require a thorough understanding of shoulder anatomy, including pain referral patterns. A complete and systematic physical examination is crucial for an accurate diagnosis. During the initial evaluation, care must be taken to discern all possible causes of shoulder pain. Final diagnosis may require repeated office examinations and correlation of diagnostic tests with symptoms and response to selective injections. Improvements in diagnostic tests, such as magnetic resonance imaging (MRI), computed tomography (CT)-arthrography, ultrasonography, and electromyography (EMG), have facilitated early diagnosis of shoulder pain and have provided a better understanding of shoulder pathology. This chapter provides practical guidelines for the diagnosis and treatment of painful shoulder disorders that may be encountered in a rheumatology or general practice. A detailed analysis of shoulder problems and information on the treatment of major trauma are beyond the scope of this chapter and have been addressed by other authors. ANATOMY AND FUNCTION Because of its complexity, an understanding of the structural and functional anatomy of the shoulder is required for the clinician who is treating shoulder pain. The shoulder joint is the most mobile joint of the body, although mobility is gained at the sacrifice of stability. Only 25% of the humeral head surface has contact with the glenoid at any time. The labrum increases the contact area of the articular surface and confers stability to the joint. 6 Lesions of the labrum may result from instability, and the type of lesion may indicate the type of instability. Labral tears also may be a source of pain from internal derangement of the shoulder. 7 Joint stability is provided by a thin capsule and by the glenohumeral ligaments, which are thickenings of the capsule anteriorly, posteriorly, and inferiorly. 6 Anterior stability is predominantly conferred by the anterior band of the inferior glenohumeral ligament. The rotator cuff provides dynamic stability of the joint. It is composed of four musculotendinous units: the supraspinatus, infraspinatus, and teres minor posteriorly, and the subscapularis anteriorly. The shoulder consists of three joints: the acromioclavicular (AC), sternoclavicular, and glenohumeral joints, and two gliding planes the scapulothoracic and subacromial surfaces. Figure 46-1 shows the musculoskeletal and topographic localization of pain associated with common shoulder disorders. Figure 46-2 shows the relationship of the three posterior rotator cuff muscles coursing anteriorly underneath the acromion to insert on the greater tuberosity. The subscapularis, the only anterior rotator cuff muscle, inserts on the lesser tuberosity. By understanding the relationship between the rotator cuff and the subacromial region, bounded inferiorly by the humeral head and superiorly by the undersurface of the acromion, the clinician can visualize the problems of impingement syndrome and can accurately 639

2 640 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN Table 46-1 Intrinsic Causes Periarticular Disorders Common Causes of Shoulder Pain Rotator cuff tendinitis or impingement syndrome Calcific tendinitis Rotator cuff tear Bicipital tendinitis Acromioclavicular arthritis Glenohumeral Disorders Inflammatory arthritis Osteoarthritis Osteonecrosis Cuff arthropathy Septic arthritis Glenoid labral tears Adhesive capsulitis Glenohumeral instability Extrinsic Causes Regional Disorders Cervical radiculopathy Brachial neuritis Nerve entrapment syndromes Sternoclavicular arthritis Reflex sympathetic dystrophy Fibrositis Neoplasms Miscellaneous Gallbladder disease Splenic trauma Subphrenic abscess Myocardial infarction Thyroid disease Diabetes mellitus Renal osteodystrophy inject this space. Knowledge of the route of the tendon of the long head of the biceps through the bicipital groove and onto the superior aspect of the glenoid helps in understanding bicipital tendinitis. Before attempting to diagnose and treat shoulder pain, the clinician should review in detail one of the many sources describing the structural and functional relationships of the shoulder girdle. 2,3 DIAGNOSIS Clinical Evaluation of the Shoulder Accurate diagnosis and successful treatment of a shoulder disorder begin with a thorough history and physical examination. Most of the information needed to make a correct diagnosis can be elicited with basic clinical skills, rather than by relying on expensive and highly technologic investigative aids. Diagnostic tests should be used only to confirm an established diagnosis or to assist in cases with a challenging presentation. History In establishing a diagnosis, it is important to consider the patient s age and chief complaint. The differential diagnosis of shoulder pain in a 70-year-old sedentary individual is entirely different from that in a 20-year-old pitcher. Did the pain occur slowly over time or suddenly with a particular event? Gradual onset of pain over the anterolateral or deltoid region that is increased with forward elevation of the shoulder and nocturnal pain suggest impingement with rotator cuff tendinopathy. The presence of significant weakness with pain on overhead activities suggests impingement with rotator cuff tear. Pain and weakness may also be noted with reaching behind the back with the shoulder in extension and external rotation, as when reaching into the back seat of a car. Initiating factors relative to the onset of symptoms should be elicited, and any history of shoulder pain or trauma should be carefully documented. Pain intensity, character, location, and periodicity and aggravating or alleviating factors should be assessed. Pain should be graded on a visual analog scale of 0 to 10, with 0 indicating no pain, and 10 indicating the worst pain the patient has ever experienced. Another indication of the severity of pain is disruption of sleep. The patient should be asked whether the pain prevents sleep or awakens the patient, and whether the patient can lie on the affected shoulder. Is the pain sharp or dull? Sharp, burning pain over the top of the shoulder indicates a neurogenic origin, whereas a dull, aching pain over the lateral deltoid suggests rotator cuff pathology with impingement. Location or distribution of the pain should be identified. Is it local around the shoulder girdle, or does the pain radiate down the arm? Is concomitant sensory loss or weakness present? Periodicity of the pain as constant or intermittent should be determined, as should factors that aggravate or alleviate the pain. Pain caused by rotator cuff tendinopathy usually is exacerbated by repetitive activities that involve the elbow away from the side of the body. Any history of neck pain should be considered, along with history of radicular pain. Radicular-type pain frequently extends below the elbow and is associated with sensory loss and weakness. Pain located in the paracervical region may indicate a cervical origin, or it can be localized to the trapezius. Trapezial pain often is associated with shoulder pain and results from the patient trying to favor the shoulder. Assuming a military brace position may produce fatiguing, spasm, and trigger points of the trapezius. Any pertinent medical history, such as a history of malignancy, should be considered. Neurologic, visceral, and vascular disease can produce referred pain to the shoulder and should always be considered, especially in a patient with a painless range of motion. Physical Examination Proper physical examination of the shoulder includes close inspection of the shoulder girdle from the front and back. The evaluation is started by standing behind the patient, who has both shoulders exposed. The normal shoulder is always inspected and compared with the injured shoulder. Examination can be performed with the patient in the sitting or standing position. Contour and symmetry are observed and compared between shoulders, and any atrophy or asymmetry in shoulder position or level is assessed. Spinatus muscle atrophy may result from disuse, chronic cuff tear, or suprascapular or brachial neuropathy. 8 If scapular winging is evident, the patient should be asked to do a wall push-up, which accentuates winging.

3 CHAPTER 46 Shoulder Pain A B C D Figure 46-1 Musculoskeletal (A and B) and topographic (C and D) areas localizing pain and tenderness associated with specific shoulder problems. 1, Subacromial space (rotator cuff tendinitis/impingement syndrome, calcific tendinitis, rotator cuff tear). 2, Bicipital groove (bicipital tendinitis, biceps tendon subluxation and tear). 3, Acromioclavicular joint. 4, Anterior glenohumeral joint (glenohumeral arthritis, osteonecrosis, glenoid labrum tears, adhesive capsulitis). 5, Sternoclavicular joint. 6, Posterior edge of acromion (rotator cuff tendinitis, calcific tendinitis, rotator cuff tear). 7, Suprascapular notch (suprascapular nerve entrapment). 8, Quadrilateral space (axillary nerve entrapment). These areas of pain and tenderness frequently overlap. Coracoclavicular ligament: Trapezoid ligament Coracoid Conoid ligament process A Clavicle Subscapularis muscle Supraspinatus muscle Subscapularis tendon Supraspinatus tendon Infraspinatus tendon Teres minor tendon Acromion of scapula Coracoacromial ligament Spine of scapula Superior margin of scapula Infraspinatus muscle B Supraspinatus muscle Clavicle Coracoid process Acromioclavicular joint Acromion Coracoacromial ligament Supraspinatus tendon Subscapularis tendon Greater tuberosity Lesser tuberosity Humerus Bicipital tendon groove Figure 46-2 A, Superior view of the rotator cuff musculature as it courses anteriorly underneath the coracoacromial arch to insert on the greater tuberosity. B, Anterior view of the shoulder reveals the subscapularis, which is the only anterior rotator cuff muscle inserting on the lesser tuberosity. It internally rotates the humerus and provides dynamic anterior stability to the shoulder. (A and B, From the Ciba Collection of Medical Illustrations, Volume 8, Part I. Netter Illustration from Elsevier Inc. All rights reserved.)

4 642 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN Range of motion should be carefully recorded, along with notation of any absence of rhythmic shoulder motion or excessive scapulothoracic motion that may compensate for the lack of glenohumeral motion. Internal rotation of the shoulder is checked by having the patient reach behind the back with the thumb while the examiner notices the vertebral level. Loss of internal rotation is seen early with shoulder pain and usually indicates some tightness of the posterior shoulder capsule. The biceps tendon; the coracoid, lesser, and greater tuberosities; and the posterior cuff are palpated, and any tenderness is gauged (Figure 46-3A). Tenderness on palpation of the long head of the biceps frequently is associated with rotator cuff tendinopathy and tenderness of the greater tuberosity. Any spasm or tenderness of the trapezius or levator scapulae may be associated with rotator cuff disease or cervical spine disease. Cervical range of motion and palpation of the paracervical muscles are carried out. Paracervical tenderness and limited range of motion of the neck may indicate cervical spondylosis or neurogenic disease. A Spurling test is done by flexing the neck laterally while applying axial compression to the skull. Pain that radiates to the ipsilateral shoulder is considered a positive test result and indicates radiculopathy. To elicit the impingement sign, the shoulder is elevated passively in forward flexion, while the scapula is depressed with the opposite hand, forcing the greater tuberosity against the anterior acromion and producing pain in cases of impingement (Figure 46-3B). 9 This maneuver also may be painful in conditions such as adhesive capsulitis, glenohumeral and acromioclavicular (AC) arthritis, glenohumeral instability, and calcific tendinitis. A dynamic impingement test, the circumduction-adduction shoulder maneuver, also called the Clancy test, is 95% sensitive and 95% specific for diagnosing rotator cuff tendinopathy, including partial tears. 10 The test is done with the patient in the standing position and with the head turned to the contralateral shoulder. The affected shoulder is circumducted and adducted across the body to shoulder level, while the elbow is kept in extension, the shoulder in internal rotation, and the thumb pointing toward the floor Sternoclavicular joint Acromioclavicular joint Subdeltoid bursa Bicipital tendon groove Greater tuberosity Examiner elevates shoulder here and... Examiner applies force here Arm adducted across chest A Glenohumeral joint space Lesser tuberosity B...depresses scapula here (from back) C Patient resists force here Pain on palpation = acromioclavicular joint impingement Patient attempts external rotation of the shoulder 30 Examiner applies force here D Pain on palpation = tight posterior capsule E Examiner applies force here F 90 Patient resists force here Figure 46-3 A, Tenderness on palpation of trigger points may help localize the site of pathology. Tenderness on palpation of the long head of the biceps and greater tuberosity suggests impingement with possible cuff tendinopathy. B, To elicit the impingement sign, the shoulder is elevated in forward flexion while the scapula is depressed with the opposite hand, forcing the greater tuberosity and the rotator cuff against the anterior acromion and producing pain when impingement exists. Relief of pain after injection of local anesthetics (i.e., impingement test) provides additional evidence of subacromial pathology. C, The Clancy test is performed with the patient standing and with the head turned toward the contralateral shoulder. The affected shoulder is circumducted and adducted across the body to shoulder level, keeping the elbow in extension with the arm internally rotated with the thumb pointed toward the floor. In this position, the patient is asked to resist maximally as a uniform downward force is applied to the extended arm by the examiner. Production of pain or weakness localized to the anterior lateral portion of the shoulder is considered a positive test result. D, The test is performed by forward flexion of the arm at 90 degrees and subsequent cross-chest adduction of the arm. Pain localized to the acromioclavicular joint is considered a positive test result. E, The test is performed with the patient s elbow flexed at 90 degrees and held at the patient s side by the examiner. The patient is asked to attempt external rotation of the shoulder from a neutral position (0 degrees of adduction) as the examiner applies resistance to the forearm. Strength is compared with that of the contralateral arm. F, Abduction strength testing is performed with the patient s shoulder in 30 degrees of forward flexion and 90 degrees of abduction and with the thumb pointed toward the floor. The patient is asked to resist as the examiner exerts a downward force on the abducted arm. Strength is compared with the contralateral shoulder. (From Martin TL, Martin SD: Rotator cuff tendinopathy, Hosp Med 12:23 31, 1998.)

5 CHAPTER 46 Shoulder Pain 643 (Figure 46-3C). In this position, the patient is instructed to resist maximally as a uniform downward force is applied to the extended arm by the examiner. The test result is considered positive if pain or weakness is elicited during the maneuver, with pain localized to the anterolateral aspect of the shoulder. A strong positive correlation of pain and weakness is noted with complete cuff tear. 10 The sternoclavicular and AC joints should be observed for prominences and palpated for stability and tenderness. Many patients with impingement have tenderness on direct downward palpation of the AC joint owing to impingement on the cuff from undersurface osteophytes of the distal clavicle. 2,8 AC joint tenderness may also result from primary AC joint arthrosis and should be differentiated by physical examination, including the cross-chest adduction test and O Brien s test. 11 Radiographic evidence of AC joint arthrosis is common in patients older than 40 years, but this condition is not usually painful. 12 The cross-chest adduction test or the horizontal adduction test is performed by forward flexing the shoulder 90 degrees with subsequent cross-chest adduction of the arm (Figure 46-3D). Pain localized to the AC joint is considered a positive test result. If pain occurs posteriorly over the shoulder, a tight posterior capsule with impingement is suspected. O Brien s test is performed by forward flexing the arm 90 degrees and adducting the arm 10 degrees out of the sagittal plane of the body. The first part of the test is performed with the hand maximally pronated with the thumb pointed down. In this position, the patient is asked to resist as the examiner applies a downward force on the arm. If the test elicits pain, the patient is asked if the pain is on top of the shoulder or deep inside. Pain localized to the top of the shoulder indicates AC joint pain, and pain deep inside the shoulder indicates a superior labrum anterior posterior (SLAP) lesion. In the second part of the test, the patient is asked to supinate the hand maximally, while the examiner applies a downward force to the arm. If the patient notices significantly less pain, the test result is positive for a SLAP lesion. If the pain is unchanged and is located on top of the shoulder, the test result is positive for AC joint pathology. 11 If the cause of AC joint tenderness is still in question, a lidocaine injection should be administered. The clinician should carefully avoid injecting the subacromial space by advancing the needle too far inferiorly through the AC joint; this can lead to false interpretation. Painful degenerative changes of the AC joint may exist concomitantly with subacromial impingement and should be evaluated thoroughly when surgical treatment (i.e., distal clavicle excision) is being considered. 13 In patients with pain out of proportion to objective findings, other causes of shoulder pain should be sought, including calcific tendinitis, infection, reflex sympathetic dystrophy, and fracture. Patients with significant wasting of the supraspinatus and infraspinatus muscles and posterior shoulder pain, especially younger patients, may have suprascapular neuropathy or brachial neuropathy (Parsonage- Turner syndrome). 8,14 Patients with chronic cuff disease frequently have variable disuse atrophy of the supraspinatus and infraspinatus fossae; in cases of chronic massive cuff tears, atrophy and weakness can be severe. Strength testing of external rotation should be done with the elbow at the side and supported by the examiner; the patient is asked to attempt external rotation of the shoulder from a neutral position (0 degrees of adduction), while the examiner applies resistance (Figure 46-3E). 15 Weakness in this position may suggest a tear of the infraspinatus tendon. Abduction strength testing against resistance is done with the shoulder in 30 degrees of forward flexion and 90 degrees of abduction, and with the thumb pointed toward the floor (Figure 46-3F). 16,17 Weakness in this position may suggest a tear of the supraspinatus tendon. A lift-off test should be performed with the shoulder in internal rotation; the patient is asked to try to hold the hand away from the back. Inability to do so indicates a subscapularis tear. If after a thorough physical examination impingement is suspected, an impingement test should be performed with injection of 5 ml of local anesthetic into the subacromial space. 18,19 Before the test is performed, the patient is asked to grade the pain during the impingement signs on a visual analog scale of 0 to 10, with 0 equal to no pain and 10 equal to the most severe pain the patient has ever experienced. The injection may be done anteriorly, laterally, or posteriorly, depending on the physician s preference. Ten minutes after injection of local anesthetic into the subacromial space, the patient should be re-examined and asked to regrade the pain on the same visual analog scale. A 50% or greater reduction in pain is thought to be a positive test result for impingement; otherwise, an alternative cause of shoulder pain should be sought, or inadequate placement of the anesthetic should be suspected. If the AC joint is thought to be contributing to the shoulder pain, 1 to 2 ml of local anesthetic should be injected into the joint, and the shoulder should be re-examined. When subacromial impingement and the AC joint are thought to be contributing to shoulder pain, serial injections during separate office visits may be needed to evaluate the shoulder while minimizing discomfort to the patient. 12 In cases of suspected bicipital tendinitis, Speed s test is performed by having the patient flex the shoulder and extend the elbow while a downward force is applied to the arm. The production of pain over the long head of the biceps is a positive test result and suggests bicipital tendinitis. Upper extremity strength testing should be performed and compared with the contralateral side so that any atrophy is detected. Grip strength is checked, and the hands are examined carefully for evidence of intrinsic atrophy. The biceps (C5), triceps (C7), and brachioradialis (C6) reflexes are checked for symmetry and briskness. Light touch sensory testing should be conducted, and the dermatomal distribution of any deficits that may suggest cervical radiculopathy should be identified. The cervical, supraclavicular, axillary, and epitrochlear regions should be palpated for enlarged lymph nodes, which may suggest malignancy. Imaging Radiographic Assessment For nontraumatic painful shoulder evaluation, standard radiographic profiles are used. An impingement series

6 644 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN should be obtained, which includes anteroposterior views with a 30-degree caudal tilt (Rockwood view), an outlet view (scapular Y with 10- to 15-degree caudal tilt), and an axillary view. Internal and external rotational views may be obtained if calcific tendinitis or instability is suspected. The Rockwood view can reveal any osteophytes off the anterior acromion and AC joint. 20 In cases of traumatic injury, a trauma series is obtained that includes a true anteroposterior view, a scapular Y view, and an axillary view. The axillary view is useful in assessing posterior or anterior subluxation of the humeral head. Additional views, such as the West Point view, which evaluates the glenoid for evidence of a bony Bankart lesion, or the Styker notch view, which assesses the humeral head for a Hill-Sachs lesion, may be obtained to assist evaluation if the diagnosis of instability is in doubt. Secondary impingement-type rotator cuff tendinitis may be caused by increased anterior translation with subluxation of the humeral head. In such cases, an axillary view or fluoroscopy can help show the subluxation. 21,22 When AC joint pathology is suspected, a 10-degree, cephalic tilt view of the AC joint at 50% penetrance, as described by Zanca, 23 should be obtained (Figure 46-4). Stress views of the AC joint may be obtained by strapping 5 to 10 lb of weight to the patient s forearms and determining AC separation. Comparing the coracoclavicular distance of both shoulders may be helpful. When clinically indicated, cervical spine radiographs should be obtained to exclude cervical spondylosis as a cause of shoulder pain. Scintigraphy Tc 99m methyl diphosphonate (MDP) or gallium may be of diagnostic help in evaluating skeletal lesions around the shoulder joint. Bone scans generally are not helpful in the Figure 46-4 Zanca view of the acromioclavicular joint is obtained with a 10-degree cephalic tilt and 50% penetrance. (From Rockwood CA Jr, Young DC: Disorders of the acromioclavicular joint. In Rockwood CA Jr, Matsen TA III, editors: The shoulder, Philadelphia, 1985, WB Saunders, pp ) 10 X-ray Figure 46-5 Normal double-contrast arthrography shows the inferior edge of the rotator cuff (RC) as it courses through the subacromial space to the greater tuberosity, the tendon of the long head of the biceps (BT), and the articular cartilage of the humeral head (AC). diagnosis of non-neoplastic or noninfectious shoulder disease. Scintigraphy may have a role in identifying patients with complete rotator cuff tears that proceed to cuff-tear arthropathy. This is an important distinction because patients with complete rotator cuff tears may do well, whereas those who develop progressive changes of cuff-tear arthropathy have progressive arthritis, pain, and significant functional impairment. Synovitis or calcium pyrophosphate deposition disease may be an important factor in the pathogenesis of cuff-tear arthropathy. In such cases, scintigraphy may show the increased blood flow and blood pooling associated with chronic synovitis. Arthrography AC RC BT Double-contrast arthrotomography (DCAT) can be used to evaluate problems of the rotator cuff, glenoid labrum, biceps tendon, and shoulder capsule Figure 46-5 shows normal DCAT of the shoulder. Rotator cuff tears can be shown by single-contrast or double-contrast studies. Proponents of double-contrast arthrography believe that the extent of the tear, the preferred surgical approach, and the quality of the rotator cuff tissue are best determined by double-contrast studies Arthrography without MRI or CT can be misleading and may result in underestimation of the extent of a rotator cuff tear. Multidetector CT can enhance the accuracy of diagnosing labral and rotator cuff tears, especially in patients for whom MRI is not possible (Figure 46-6). Tears of the glenoid labrum without shoulder dislocation are sources of anterior shoulder pain in athletes. 7 Glenoid labrum tears (Figure 46-7), with or without associated glenohumeral subluxation, frequently can be identified by DCAT. 27,28 Kneisl and colleagues 30 described 55 patients who underwent DCAT followed by diagnostic shoulder

7 CHAPTER 46 Shoulder Pain 645 Figure 46-6 Multidetector computed tomography revealing a superior labral tear of the shoulder. arthroscopy. DCAT predicted the arthroscopic findings in 76% of anterior labrum studies and 96% of posterior labrum studies. This test was 100% sensitive and 94% specific in diagnosing complete rotator cuff tears. Partial rotator cuff tears identified at arthroscopy were missed in 83% of patients undergoing DCAT. Investigators believed that DCAT was better in diagnosing intra-articular and cuff pathology in cases of instability than when pain alone was the presenting diagnosis. 30 Shoulder arthrography can confirm a diagnosis of adhesive capsulitis by showing a contracted capsule with an obliterated axillary recess (Figure 46-8). The use of subacromial bursography has been beneficial in visualizing the outer surface of the rotator cuff and the subacromial space in cases of impingement. 31,32 Fukuda and associates 33 reported a small series of younger patients (average age, 41.8 years) who underwent subacromial bursography after a negative glenohumeral arthrographic result. These patients showed pooling of contrast medium on the bursal side of a tear, which was confirmed at the time of surgery. Subacromial Figure 46-7 Double-contrast arthrotomography shows a tear of the anterior-inferior portion of the glenoid labrum (arrow). Figure 46-8 Double-contrast arthrography of a patient with calcific tendinitis (arrow) and adhesive capsulitis. Notice the contracted capsule with diminution of the synovial space and obliteration of the axillary recess. bursography is not routinely used diagnostically, and, in our opinion, it is of little value in planning surgical procedures. Computed Tomography CT is helpful in evaluating the musculoskeletal system, and CT combined with contrast arthrography (CT-arthrography) has become a major diagnostic tool for the evaluation of glenoid labrum tears, loose bodies, and chondral lesions (Figure 46-9). Rafii and co-workers 34 reported using CT-arthrography in an evaluation of shoulder derangement. This study found 95% accuracy of CT-arthrography for investigating lesions of the labrum and articular surface. 34 More recently, multidetector CT-arthrography scans have been used to evaluate partial cuff tears (Figure 46-10A), cystic lesions (Figure 46-10B), and calcific tendinopathy (Figure 46-10C). Ultrasonography Technologic improvements in ultrasound equipment have led to improved ultrasound study of the rotor cuff. The technique is noninvasive, is rapid, and involves no radiation exposure ,35 The cuff is examined in the horizontal and transverse planes with the arm in different positions to allow visualization of various areas of the cuff. These techniques generally provide visualization of the distal cuff, where most rotator cuff tears are located. Figure shows normal and abnormal ultrasound images of the rotator cuff in longitudinal and transverse planes. Several studies report high sensitivity and specificity for the diagnosis of a rotator cuff tear by ultrasound The specificity and sensitivity of the procedure are reported to be greater than 90% as determined by arthrographic and surgical correlations. 34,35 This technique also has been used for the postoperative evaluation of a rotator cuff repair and for evaluation of abnormalities of the biceps tendon

8 646 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN A B C D Figure 46-9 CT-arthrography of the shoulder. A, Normal findings. B, Tear of the anterior glenoid labrum. C, Large defect of the articular surface of the posterior portion of the humeral head (Hill-Sachs lesion) (arrow). D, Loose body in the posterior recess (arrow). Gardelin and Perin 41 reported ultrasound to be 96% sensitive in determining rotator cuff and biceps tendon pathology. Mack and associates 36 found ultrasound to be valuable in evaluating postoperative patients with recurrent shoulder symptoms. In a prospective study, Hodler and colleagues 39 compared ultrasound with MRI and arthrography in evaluating rotator cuff lesions in 24 shoulders. Ultrasound identified 14 of 15 torn cuffs, MRI identified 10 of 15, and arthrography identified 15 of Ultrasound identified 7 of 9 intact rotator cuffs, whereas MRI was accurate in 8 of 9 intact cuffs. 39 Vestring and colleagues 42 found ultrasound to be as accurate as MRI in the diagnosis of humeral head defects and joint effusions, but inferior to MRI in the diagnosis of labrum lesions, rotator cuff lesions, subacromial spurs, and synovial inflammatory disease. In the hands of an experienced sonographer, ultrasound may be the most costeffective test for the initial evaluation of a rotator cuff injury, but most surgeons require CT-arthrography or MRI confirmation before beginning surgical exploration. 36,39,41-43 Arthroscopy The use of arthroscopy for the diagnosis of shoulder pathology increased in the 1980s, in part because of its accuracy, which was far greater than that of clinical examination and better than the accuracy of other diagnostic modalities of the time. With technologic advances in fiberoptics, video output, and arthroscopic instrumentation, the use of arthroscopy to diagnose and treat shoulder problems exponentially increased to include procedures previously used only for open techniques. 44 Compared with DCAT, arthroscopy is more accurate in the diagnosis of intra-articular lesions associated with a painful shoulder. 30 An additional benefit is that arthroscopy can be used to diagnose and treat shoulder problems of the glenohumeral joint and the subacromial region. With increased accuracy of MRI-arthrography in detecting partial cuff tears and labral lesions, diagnostic shoulder arthroscopy has become less common in the absence of clear indications and specific treatment plans. In combination with a detailed history and physical examination, and along with examination under anesthesia, shoulder arthroscopy has been helpful in the diagnosis of chronic instability patterns of the glenohumeral joint The indications and usefulness of shoulder arthroscopy in the treatment of common pathologic conditions have continued to increase as the technology improves, and as understanding of the pathophysiology of shoulder problems grows. Shoulder arthroscopy has been used routinely to confirm and treat SLAP lesions, labral tears, partial cuff

9 CHAPTER 46 Shoulder Pain 647 A B C Figure Multidetector computed tomography arthrography. A, Partial rotator cuff tear (coronal view). B, Cystic humeral head erosions with calcification (axial view). C, Calcification within rotator cuff tendon (coronal view). tears, refractory adhesive capsulitis, partial biceps tendon tears, and multidirectional instability. Other conditions that are routinely treated arthroscopically include rotator cuff tears, glenohumeral instability, AC joint pathology, loose bodies, sepsis, osteochondritis dissecans, synovitis, chondral lesions, subacromial impingement, and calcific tendinitis. 7,13,44,47 Magnetic Resonance Imaging MRI has been used to diagnose partial-thickness and fullthickness rotator cuff tears, biceps tendon tears, impingement of the rotator cuff, synovitis, articular cartilage damage, and labral pathology associated with glenohumeral instability In rheumatoid arthritis, MRI is reported to be more sensitive than plain radiographs in determining soft tissue abnormalities and osseous abnormalities of the glenoid and humeral head. 51 One of the most valuable diagnostic uses of MRI is in rotator cuff pathology. Morrison and Offstein 52 studied 100 patients with chronic subacromial impingement syndrome using arthrography and MRI. MRI was 100% sensitive but only 88% specific in confirming arthrography-proven rotator cuff tears. Nelson and associates 53 studied 21 patients with shoulder pain and found MRI to be more accurate than CT-arthrography or ultrasound in identifying partialthickness cuff tears. These investigators also reported MRI to be as accurate as CT-arthrography in the diagnosis of abnormalities of the glenoid labrum. 53 Characteristic MRI findings in rotator cuff tears include a hypointense gap within the supraspinatus muscle tendon complex on T1-weighted films, absence of a demonstrable supraspinatus tendon with narrowing of the subacromial space, and an increased signal within the supraspinatus tendon on T2-weighted images. 54 Seeger and colleagues, 55 reporting the results of 170 MRI studies, found that T1-weighted images were highly sensitive for identifying abnormalities within the supraspinatus tendon, but T2-weighted images were required to differentiate tendinitis from a small supraspinatus tendon tear. Large full-thickness tears could be identified, however, on T1-weighted and T2-weighted images. Figure depicts common shoulder pathology as seen by MRI. MRI is almost as sensitive as and is more specific than scintigraphy in the diagnosis of osteonecrosis and neoplastic lesions around the shoulder. Electromyography and Nerve Conduction Velocity Studies EMG and nerve conduction velocity studies can help differentiate shoulder pain from pain of neurogenic origin. They also may be beneficial in determining the localization of neurogenic pain to a particular cervical root, the brachial plexus, or a peripheral nerve. 56,57

10 648 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN A B C D Figure A, Normal longitudinal view of rotator cuff by ultrasound shows the humeral head (1), the superior articular surface (2), the rotator cuff (3), the deltoid tendon (4), and tapering of the cuff to its insertion on the greater tuberosity (5). B, Transverse view of a normal intact rotator cuff covering the humeral head. C, Rotator cuff tear, showing a hypoechoic area (arrow) on a longitudinal view. D, Rotator cuff tear, showing hypoechoic area (arrows) on a transverse view. Injection Injection of local anesthetics and glucocorticoids is a useful technique for the diagnosis and treatment of shoulder pain. 58 The physician must have a thorough understanding of the anatomy of the shoulder girdle and a presumptive diagnosis to direct the injection properly. Injection of referred pain areas may be misleading. In a patient with lateral arm pain secondary to deltoid bursal involvement from calcific tendinitis of the supraspinatus tendon, injection should be performed in the subacromial space, rather than in the area of referred pain in the deltoid muscle. It is often better to use a posterior or lateral subacromial approach when injecting a rotator cuff tendinitis in a patient with anterior impingement symptoms because it is easier to enter the subacromial region posteriorly or laterally, and this approach is less traumatic for contracted anterior structures. The instillation of rapidly acting local anesthetics can be beneficial in determining the source of shoulder pain. Obliteration of pain by injection of a local anesthetic along the bicipital groove can confirm a diagnosis of bicipital tendinitis. The use of local anesthetics is less helpful when the subacromial space is injected because of its extensive communication with the rest of the shoulder girdle, but relief of symptoms by such an injection can exclude pain from conditions such as cervical radiculopathy or entrapment neuropathy. Potential Diagnostic Tests Table 46-2 lists reimbursement and charges for various shoulder diagnostic tests based on 2011 Medicare fee schedules and 2011 charges at a single institution. The choice of a specific test depends on its sensitivity, specificity, and costbenefit analysis. History and physical examination are the most important factors in establishing diagnosis of the painful shoulder. Plain radiographs (three views) should be the first radiographic tests performed. Although not as sensitive as the more sophisticated tests, plain radiographs can identify arthritic change, calcific tendinitis, established osteonecrosis, and most neoplasms. If intra-articular pathology (e.g., labrum tear, capsular tear, loose body, chondral defect) is suspected, MRIarthrography is preferable to CT-arthrography. In diagnosing acute rotator cuff tears in a younger patient, ultrasound is the most cost-effective test to confirm a clinical suspicion. In cases of impingement syndrome, MRI is sensitive, but it is difficult to differentiate tendinitis, partial tears, and small complete tears without MRI-arthrography. Orthopedic surgeons prefer MRI-arthrography for verification of labral tears or partial rotator cuff tears. In the case of a suspected full-thickness rotator cuff tear, MRI is preferred to determine the size of the tear, the amount of muscle atrophy and tendon retraction, and the quality of remaining tissue for repair.

11 CHAPTER 46 Shoulder Pain 649 A B A B B A B A C D E F Figure A, Magnetic resonance imaging (MRI) proton density weighted coronal view shows the supraspinatus tendon as a black band (A) that has an increased signal as it nears insertion on the greater tuberosity (B). B, Similar view in a T2-weighted image shows increased signal as gray (arrow), indicating a partial-thickness tear or tendinitis. C, MRI proton density weighted coronal view shows abrupt end of supraspinatus tendon as it courses right to left (A). From A to B is an area of increased signal followed by a short portion of tendon (B) inserting at the greater tuberosity. D, Similar view in a T2-weighted image shows increased signal as white (fluid density), indicating fluid in the gap of a complete rotator cuff tear. E, MR arthrography shows a normal rotator cuff. F, MR arthrography shows a chronic cuff tear with retraction. INTRINSIC FACTORS CAUSING SHOULDER PAIN Periarticular Disorders Shoulder Impingement and Rotator Cuff Tendinopathy One of the most common nontraumatic causes of shoulder pain is impingement with rotator cuff tendinopathy. In 1972, Neer 9 described his results of 100 anatomic shoulder dissections and coined the term impingement syndrome. Impingement may be defined as the encroachment of the acromion, coracoacromial ligament, coracoid process, or AC joint on the rotator cuff as it passes beneath them during glenohumeral motion. The function of the posterior rotator cuff is to abduct and externally rotate the humerus. The cuff with the biceps tendon serves as a humeral head depressor to maintain the head centered within the glenoid fossa as the cuff and to use the deltoid to elevate the arm Controversy continues, however, as to the exact cause of impingement, that is, whether it is a primary, intrinsic, degenerative event within the tendon with superior migration of the head on arm elevation and secondary

12 650 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN Table 46-2 Relative Costs of Shoulder Diagnostic Procedure in 2011 Procedure Initial Fee (USD) Technical Fee (USD) Interpretation Fee (USD) Medicare B Fee Schedule Initial office visit (30 min) Plain radiography (3 views) Arthrography Ultrasonography Magnetic resonance imaging Computed tomography Tomography Institutional Charges Initial office visit (30 min) Plain radiography (3 views) Arthrography Ultrasonography Magnetic resonance imaging Computed tomography USD, U.S. dollars. impingement on the acromion, or purely mechanical attrition of the tendon with primary impingement against the acromion. The mechanical impingement of the rotator cuff may be influenced by variations in the shape and slope of the acromion. 62,63 The supraspinatus outlet may become narrowed from proliferative spur formation of the acromion or degenerative changes in the AC joint. These changes, along with intrinsic degenerative changes of the rotator cuff, may lead to rotator cuff tear, but the exact pathogenesis remains controversial. Many studies have found a strong correlation between degenerative hypertrophic spur formation, with its resulting narrowing of the supraspinatus outlet, and the presence of full-thickness cuff tears, 9,19,64-71 but clinical studies have failed to confirm whether hypertrophic changes in the coracoacromial arch are caused by the cuff lesions, or whether these changes themselves cause the lesions. Neer 9 developed a staging system for description of impingement lesions of the shoulder. A stage I lesion involves edema and hemorrhage of the rotator cuff and is typically found in individuals younger than 25 years who are active in overhead athletics. The condition usually responds to conservative treatment that includes rest, antiinflammatory medication, and physical therapy. Stage II lesions usually occur in the 30s or 40s and represent the biologic response of fibrosis and thickening of the tendon after repeated episodes of mechanical impingement over time. Lesions are treated conservatively, as in stage I, but attacks may recur. If symptoms persist despite adequate conservative management for longer than 6 to 12 months, surgical intervention is warranted. Stage III lesions involve rotator cuff tears, biceps tendon rupture, and bone changes, and they rarely occur before age 40. Patients may present with pain, weakness, or supraspinatus atrophy, depending on the chronicity of the tear. Surgical treatment depends on the patient s age, loss of function, weakness, and pain. Patients usually present to the clinician with a complaint of pain that has failed to resolve after a variable period. Pain can be sudden and incapacitating in cases of traumatic cuff tears, or more commonly may manifest as a dull ache in cases of chronic impingement. Pain usually is located over the anterior and lateral aspects of the shoulder and may radiate into the lateral deltoid. It may worsen with sleeping on the affected extremity and is exacerbated by overhead activity. Tenderness on palpation may be elicited over the greater tuberosity and the long head of the biceps within the bicipital groove, indicating an associated biceps tendinitis. In cases with concomitant degenerative changes in the AC joint, tenderness may be noted on palpation over the AC joint, as an offending osteophyte impinges on the rotator cuff beneath. The impingement sign as described by Neer 9 (Figure 46-13) is useful in the diagnosis of rotator cuff tendinopathy. The patient often describes a catch as the arm is brought into the overhead position. The patient may be observed to raise the arm by abduction and external rotation to clear the greater tuberosity of the acromion, bypassing the painful area. A typical painful arc usually occurs between 70 degrees and 110 degrees of abduction. Neer 9 also described an impingement test that involves injection of lidocaine into the subacromial bursa. Relief of pain is a positive impingement test result and usually indicates rotator cuff origin of the shoulder pain. Figure The impingement sign is elicited by forced forward elevation of the arm. Pain results as the greater tuberosity impinges on the acromion. The examiner s hand prevents scapular rotation. This maneuver may be positive in other periarticular disorders. (From Neer CS II: Impingement lesions, Clin Orthop Relat Res [173]:70, 1983.)

13 CHAPTER 46 Shoulder Pain 651 Radiographs in the early stages of cuff tendinopathy may be normal or may reveal a hooked acromion. As the disease progresses, sclerosis, cyst formation, and sclerosis of the anterior third of the acromion and the greater tuberosity may be observed. An anterior acromial traction spur may appear on the undersurface of the acromion lateral to the AC joint and represents contracture of the coracoacromial ligament. Late radiographic findings include narrowing of the acromiohumeral gap, superior subluxation of the humeral head in relation to the glenoid, and erosive changes in the anterior acromion. 71 Arthrography, MRI, and ultrasound may be helpful in diagnosing a full-thickness tear of the rotator cuff in association with stage III disease. In some cases of chronic large rotator cuff tears, proximal migration of the humeral head leads to a pattern of degenerative arthritis termed cuff-tear arthropathy. The choice of treatment and frequently its result are functions of the stage of the impingement and the response to pain. In stage I disease, in which little mechanical impingement occurs, most patients respond to rest. It is important to avoid immobilizing the shoulder for any period because contraction of the shoulder capsule and periarticular structures can produce an adhesive capsulitis. After a period of rest, a progressive program of stretching and strengthening exercises generally restores the shoulder to normal function. Use of aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) may shorten the symptomatic period. Modalities such as ultrasound, neuroprobe, and transcutaneous electrical nerve stimulation generally are not helpful. Patients with stage I or II disease may have a dramatic response to local injection of glucocorticosteroids and local anesthetic agents. For stage II disease in which fibrosis and thickening occur anteriorly, it is frequently better to inject through a posterior approach. We prefer a combination of 3 ml of 1% lidocaine (Xylocaine), 3 ml of 0.5% bupivacaine, and 20 mg of triamcinolone. This injection combines a short-acting anesthetic to help confirm the diagnosis, a longer-acting anesthetic for analgesic purposes, and a steroid preparation in a depot form. An integrated program of occupational and physical therapy often precludes the need for surgery in patients with stage II disease. Job modification for individuals with impingement syndrome caused by overuse may alleviate symptoms. Businesses are becoming increasingly aware of the cost savings associated with proper job ergonomics. 72,73 The initial rehabilitation in stage II impingement consists of cessation of repetitive overhand activity. Ice, NSAIDs, and local injections also may be beneficial. Initial physical therapy includes passive, active-assisted, and active range of motion combined with stretching and mobilization exercises to prevent contracture. As pain and inflammation subside, isometric or isotonic exercises are used to strengthen the rotator cuff musculature. Isokinetic training at variable speeds and in variable positions is instituted before the patient is returned to full activity. For patients with a jobrelated injury, it is crucial to review and modify job mechanics to prevent recurrent episodes that can cause further disability and may precipitate the need for surgery. 72 Neer 19 suggested that a patient with refractory stage II disease may respond to division of the coracoacromial ligament and bursectomy of the subacromial bursa. Open anterior acromioplasty as described by Neer has become accepted as the procedure of choice for stage II and III impingement lesions, with many investigators reporting high success rates in treating impingement syndrome and rotator cuff tears Reported results show good and excellent relief of symptoms in 71% to 87% of patients treated by the open surgical procedure In 1985, Ellman 45 described the technique of arthroscopic subacromial decompression. His initial results 46 and the results of others are comparable with those of open surgical techniques. 47,82 Arthroscopic subacromial decompression has become a widely accepted treatment for refractory stage II and III impingement lesions. The procedure can be done as outpatient surgery, and because no deltoid is detached, as with the open technique, the procedure facilitates rehabilitation and increases overall recovery rates. Calcific Tendinitis Calcific tendinitis is a painful condition around the rotator cuff that is associated with deposition of calcium salts, primarily hydroxyapatite The cause of calcific tendinitis is unknown. The commonly accepted cause is degeneration of the tendon, which leads to calcification through a dystrophic process. 85 A common clinicopathologic correlation is seen in three distinct phases of the disease process: the precalcific or formative phase, which can be relatively painless; the calcific phase, which tends to be quiescent and may last months to years; and the resorptive or postcalcific phase, which tends to be painful, as calcium crystals are resorbed. 83 Although it is more common in the right shoulder, at least a 6% incidence of bilaterality has been reported. Patients with bilateral shoulder involvement often have the syndrome of calcific periarthritis, in which calcium hydroxyapatite crystals are found at multiple sites. 86 Patients usually present with impingement-type pain in the affected shoulder during overhead activity. The pain may seem to be out of proportion to any objective physical findings. The patient may describe difficulty sleeping on the shoulder and trouble falling asleep. Symptoms may last a few weeks or a few months. The incidence of calcific tendinitis varies in the literature among asymptomatic individuals from 2.7% to 20%. Most calcification occurs in the supraspinatus tendon, and 57% to 76.7% of patients are women. The average age of patients is 40 to 50 years. 83,87 Codman 1 pointed out the localization of calcification within the tendon of the supraspinatus. He provided a detailed description of the symptoms and the natural history of this condition. In describing the phases of pain, spasm, limitation of motion, and atrophy, he noted the lack of correlation between symptoms and the size of the calcific deposit. According to Codman, the natural history includes degeneration of the supraspinatus tendon, calcification, and eventual rupture into the subacromial bursa. During the latter phase, pain and decreased motion can lead to adhesive capsulitis (see Figure 46-8). Several factors may affect localization of calcium within the supraspinatus. Many patients have an early stage of impingement, which compresses the supraspinatus tendon on the anterior portion of the acromion. 9,19 This longstanding impingement may lead to local degeneration of tendon fibers. In patients without impingement,

14 652 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN localization of calcium within the supraspinatus may be related to the blood supply of the rotator cuff, which normally is derived from an anastomotic network of vessels from the greater tuberosity or from the bellies of the short rotator muscles. 84 The watershed of these sources is just medial to the tendinous attachment of the supraspinatus. 88 Rathburn and Macnab 89 referred to this watershed as the critical zone and pointed out that during abduction this area was rendered ischemic. Treatment of calcific tendinitis depends on the clinical presentation and the presence of associated impingement. Patients can have an acute inflammatory reaction that may resemble gout. The acute inflammation can be treated with local glucocorticoid injection, NSAIDs, or both. Ultrasound may be beneficial. If impingement is associated, treatment depends on the stage at presentation. The radiographic appearance of the calcification can direct and perhaps predict the response to therapy. In the resorptive state, deposits appear floccular, suggesting that the process is in the phase of repair, and that a conservative program is indicated. Patients with discrete calcification and perhaps associated adhesive capsulitis (see Figure 46-8) may be at a stable phase, in which calcium produces a mechanical block and is unlikely to be resorbed. For these patients, mechanical removal of calcific deposits and correction of associated pathologic lesions may be necessary Percutaneous disruption of calcified areas may be performed using a needle directed by fluoroscopy. This technique allows lavage and injection, but does not treat associated impingement. Subacromial arthroscopy allows mechanical débridement of calcific deposits under direct visualization. This technique can be combined with arthroscopic removal of the inflamed bursa and decompression of associated impingement. Improved results have been noted with complete removal of calcific deposits. 93 In many cases of refractory calcific tendinitis associated with impingement, open or arthroscopic acromioplasty, subacromial bursectomy, and decompression are indicated. Rotator Cuff Tear Pathophysiology Spontaneous tear of the rotator cuff in an otherwise normal individual is rare. 19 It can occur in patients with rheumatoid arthritis or systemic lupus erythematosus as part of the pathologic process with invasion from underlying pannus. Metabolic conditions such as renal osteodystrophy and agents such as glucocorticoids occasionally are associated with cuff tears. Most patients report a traumatic episode, such as falling on an outstretched arm or lifting a heavy object. The usual presenting symptoms are pain and weakness of abduction and external rotation. Crepitus and even a palpable defect may be associated. Long-standing tears generally are associated with atrophy of the supraspinatus and infraspinatus muscles. It may be difficult to differentiate a painful tendinitis from a partial-thickness or a small fullthickness cuff tear. Controversy continues about the exact cause of cuff tendinopathy. 88,92,94,95 Most likely, the pathophysiology involves a combination of factors, including decreased vascularity and cellularity of the tendon, along with changes in the collagen fibers of the tendon that occur with aging. Loss of motion with subsequent capsular tightness, particularly in the posterior capsule, may lead to cephalad migration of the humeral head, with subsequent impingement of the cuff under the coracoacromial arch. 96 Rehabilitation exercises stress regaining a normal range of motion. To achieve full, painless motion, the normal relationship of glenohumeral to scapulothoracic motion must be achieved. 16,17,97 Diagnosis History. Patients with nontraumatic tears of the rotator cuff report symptoms of chronic impingement. Loss of motion and a feeling of stiffness are often noted with extremes of motion, along with difficulty during activities of daily living, such as combing the hair, hooking a bra strap, putting on a shirt or coat, and reaching into the back pocket. In chronic cases of cuff tendinopathy, loss of motion usually occurs. Limitation of internal rotation occurs initially, is caused by posterior capsular contracture, and is often associated with posterior shoulder pain with adduction of the ipsilateral shoulder. Further shoulder impingement occurs with forward flexion because of superior migration of the humeral head against the anterior inferior acromion. This upward translation is analogous to the action of a yo-yo climbing on a string. 96,98 Over time, loss of forward flexion, abduction, and external rotation occurs with passive and active motion of the shoulder. Imaging. In acute cases, a history of trauma, such as a fall onto the affected shoulder, may be reported. In cases involving an anterior shoulder dislocation with subsequent profound weakness of the rotator cuff, a large cuff tear or a greater tuberosity avulsion should be suspected, in addition to axillary nerve palsy. In younger patients, traumatic failure of the cuff under tensile overload may result in cuff failure caused by forced adduction of the affected shoulder or active abduction against resistance, and this may occur with traumatic dislocation. Repetitive tensile overload also can result in partial rotator cuff tears in an overhead athlete. Plain radiographs are used in initial evaluation of impingement-type shoulder pain with cuff tendinopathy. An impingement series should be ordered, including an anteroposterior radiograph with a 30-degree cephalic tilt (Rockwood view), which can reveal osteophytes of the anterior os acromion and AC joint; a scapular Y view with a 10-degree cephalic tilt (supraspinatus outlet view), which can evaluate the type of acromion and reveal anterior and AC osteophytes; and an axillary view, which can evaluate the acromion for possible os acromionale. Calcific deposits within the rotator cuff tendon can be viewed best with rotational anteroposterior radiographs. Cuff arthropathy should be suspected if the acromial-humeral distance is less than 7 mm, or with the presence of cyst formation within the greater tuberosity, humeral head osteopenia, sclerosis around the greater tuberosity, or humeral head collapse. In advanced stages of cuff arthropathy, complete loss of glenohumeral joint space may be seen with superior migration and abutment of the humeral head against the undersurface of the acromion. 59

15 CHAPTER 46 Shoulder Pain 653 In the past, shoulder arthrography was considered the gold standard for diagnosing full-thickness and partialthickness rotator cuff tears, with greater than 90% sensitivity and specificity. 33,99 Currently, arthrography with CT or MRI is routinely used to diagnose rotator cuff pathology, including full-thickness and partial-thickness tears. Ultrasonography has been accurate in the diagnosis of full-thickness rotator cuff tears. 39, Ultrasonography offers the advantages of being inexpensive and noninvasive, but disadvantages include unproven effectiveness in determining subacromial impingement, capsular and labral abnormalities, and partial cuff tears. The procedure and its results are technician dependent. Ultrasonography may have a useful role in determining the postoperative integrity of the cuff repair. 38 MRI has been invaluable in evaluating rotator cuff tears. Sensitivity and specificity of MRI for diagnosing fullthickness cuff tears are 100% and 95%. 104 Through the use of gadolinium or saline, partial tears that are otherwise difficult to detect with conventional imaging can be detected. Diagnosing cuff tears with MRI usually is based on discontinuity of the tendon on T1-weighted images and consistency with fluid signal on T2-weighted images. Ancillary findings include fluid in the subacromial space on T2-weighted images, loss of the subacromial fat plane on T1-weighted images, and proliferative spur formation of the acromion or AC joint. Large, chronic cuff tears also may be associated with cephalad migration of the humeral head and fatty atrophy of the spinatus muscle. Periarticular soft tissues, including the capsulolabral complex and the biceps tendon, as well as the rotator cuff can be thoroughly examined. The degree of tear and tendon retraction and evidence of muscle atrophy can be evaluated, all of which are crucial in preoperative planning for possible cuff repair. Treatment Nonsurgical Treatment. Codman and Akerson 64 recommended early operative repair for acute full-thickness rotator cuff tears and reported the first documented repair in McLaughlin 66 recommended early repair in cases of grossly displaced tuberosity fractures or massive tears. Several other clinical studies have supported the concept that a full-thickness tear does not preclude good shoulder function. DePalma 105 reported that 90% of patients with rotator cuff tears responded to conservative measures, such as rest, analgesics, anti-inflammatory agents, and physiotherapy. The reported percentage of patients responding to nonsurgical treatment in the literature varies from 33% to 90%. 3,18,106 Conservative treatment includes pain control with NSAIDs, ultrasound, heat before shoulder stretching and exercise, and ice after overhead activity. Deep massage therapy is employed to reduce trigger point tenderness within the trapezius, levator scapulae, and periscapular muscles. Patients on long-term anti-inflammatory medications are monitored periodically for evidence of gastrointestinal bleeding and for hepatic or renal toxicity. Opiate-based drugs are used only in the acute setting, such as after a fall, or in the perioperative period. Steroid and local anesthetic injections are used when the patient has significant pain that prohibits rehabilitation. Injections may be repeated once every 3 months if needed; injection into the cuff tendon is to be avoided. If the patient fails to improve after 3 months of conservative treatment, or does not continue to improve after three sequential injections, surgical options should be discussed. The mainstay of conservative therapy is exercise. Rehabilitation stresses pain relief with exercises aimed at restoring shoulder motion and strengthening remaining cuff muscles, deltoid, and scapular stabilizers. Therapy can be divided into three phases. The goals of the initial phase of therapy are to relieve pain and restore shoulder motion. Motion therapy includes pendulum exercises, passive motion with use of a wand with assistance of the uninvolved shoulder, an overhead pulley system, and posterior capsular stretching. The arc of motion is gradually increased and is guided by the patient s discomfort to avoid painful impingement arcs. The second phase of therapy is entered after the patient has return of motion and little discomfort with overhead activity. Emphasis is placed on strengthening the remaining rotator cuff musculature and deltoid and periscapular muscles. Strengthening with elastic surgical tubing provides variable degrees of resistance, depending on the size of the tubing. Initial strengthening is performed out of the impingement arc (70 to 120 degrees of shoulder flexion). The goal of this phase is to strengthen the shoulder to prevent dynamic proximal humeral migration with impingement during active shoulder elevation. 59,61 Normal shoulder kinematics relies on combined and synchronous glenohumeral flexion and scapular rotation. 60,92 In addition to strengthening the cuff and deltoid, the scapular rotators, including the trapezius and the serratus anterior muscles, are emphasized. 107 After the patient has successfully completed phase two of the rehabilitation program with minimal symptoms and good shoulder function, the final phase is entered. Phase three is characterized by a gradual return to normal overhead activities, including work and sporting activities. This part of the rehabilitation program should be tailored to the individual patient s needs and the demands placed on the shoulder. Surgical Treatment. A Cochrane review of the effectiveness of surgery for rotator cuff disease failed to reach any firm conclusions about the effectiveness or safety of rotator cuff surgery. 108 Severity and duration of pain are the primary indications for surgical intervention in a rotator cuff tear. Other factors important in surgical decision making include shoulder dominance, activity level, physiologic age, acuteness of the tear, degree of tear, loss of function, amount of tendon retraction, and fatty atrophy of the remaining cuff musculature. A systematic review of indications for rotator cuff surgery found that earlier surgical intervention may be needed for patients with cuff tears with weakness and significant functional disability. In addition, older chronologic age did not portend a worse outcome; however, pending workman s compensation claims, it did negatively affect treatment results. 109 Acute Tears. Acute tears of the rotator cuff can be treated with conservative measures of periscapular and cuff strengthening along with capsular stretching to restore

16 654 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN motion. Early surgical intervention should be considered in a young patient, especially an overhead athlete. Conservative shoulder rehabilitation should be maintained for 3 to 6 months before a decision is made regarding surgery for an older sedentary patient, in whom functional results without surgery may be acceptable. Many older patients may function well with chronic cuff tears, but they may become debilitated if an acute tear is superimposed on chronic changes. Surgical intervention may be required in these cases to return the patient to baseline function by repairing the acute tear and attempting to repair the chronic tear if possible. Chronic Tears. For elderly patients whose pain and weakness do not create a functional problem, a conservative program is preferable for chronic tears. Pain unresponsive to conservative management is the main indication for surgery in an older patient with a chronic rotator cuff tear. In these cases, surgery should be considered on an individual basis after at least 3 months of conservative treatment, including subacromial steroid injection. If the cuff tear is massive and irreparable, débridement and subacromial decompression may provide good pain relief without extensive surgery and prolonged immobilization. 46,82, In a younger patient with a chronic tear and weakness, surgery to repair the cuff may be indicated to improve strength and prevent further extension of the tear. 112 In cases of rotator cuff arthropathy with glenohumeral joint degeneration, a reverse total shoulder replacement may be indicated. This type of total shoulder replacement reverses the normal relationship between scapular and humeral components, moving the center of rotation medially and distally to increase the lever arm length of the deltoid muscle. The deltoid compensates for the deficient rotator cuff, allowing as near-normal function as possible (Figure 46-14). A recent publication also suggested reverse Figure Reverse total shoulder replacement in a 72-year-old man who had severe cuff arthropathy. total shoulder arthroplasty for the treatment of irreparable rotator cuff tear with disability and no glenohumeral arthritis. 115 Bicipital Tendinitis and Rupture The long head of the biceps passes through the bicipital groove, crosses over the head of the humeral, and inserts on the superior rim of the glenoid (see Figure 46-1A). 116 The biceps tendon aids in flexion of the forearm, supination of the pronated forearm if the elbow is flexed, and forward elevation of the shoulder. 3 Bicipital tendinitis, subluxation or dislocation of the biceps tendon within the bicipital groove, and rupture of the long head of the biceps generally are associated with anterior shoulder pain. Bicipital tendinitis is sometimes an associated feature of a rotator cuff tear. The rotator cuff tear compromises centering of the humeral head on the glenoid. This compromise results in increased mechanical loading of the long head of the biceps, which initiates a hypertrophic tendinitis. 117 Dislocation of the long head of the biceps usually is combined with a lesion of the subscapularis tendon. 12 Isolated rupture of the long head of the biceps tendon is rare when the rotator cuff is intact. Rupture of the long head of the biceps is common, however, when a coexisting rotator cuff tear is present. 118 The effects of rotator cuff tear and concomitant biceps tendon rupture on strength can be substantial. 12 Early phases of bicipital tendinitis are associated with hypervascularity, edema of the tendon, and tenosynovitis. 119 Persistence of this process leads to adhesions between the tendon and its sheath, along with impairment of the normal gliding mechanism in the groove. Stretching of the adhesions may be associated with chronic bicipital tendinitis. 120 The diagnosis of bicipital tendinitis is based on localization of tenderness. It is often confused with impingement symptoms and is frequently seen with an impingement syndrome. 24 Isolated bicipital tendinitis can be differentiated by the fact that the tender area migrates with the bicipital groove as the arm is abducted and externally rotated. Many eponyms are associated with tests to identify bicipital tendinitis. 3 Yergason s supination sign refers to pain in the bicipital groove when the examiner resists supination of the pronated forearm with the elbow at 90 degrees. Ludington s sign refers to pain in the bicipital groove when the patient interlocks the fingers on top of the head and actively abducts the arms. Biceps tendon rupture can occur in some patients who report no history of shoulder pain. Patients often complain of an acute onset of pain and ecchymosis around the anterior shoulder and sagging of the biceps muscle belly. In these cases, a concomitant rotator cuff injury should be excluded by clinical examination. More often, the biceps tendon rupture is preceded by painful shoulder symptoms that often improve or disappear after the rupture. 120,121 Treatment generally is conservative and consists of rest, analgesics, NSAIDs, and local injection of glucocorticoids. The use of ultrasound and a neuroprobe is more beneficial in this condition than in isolated rotator cuff tendinitis. Patients with refractory bicipital tendinitis and recurrent symptoms of subluxation are treated by arthroscopic biceps tenodesis or open tenodesis, that is, opening the bicipital

17 CHAPTER 46 Shoulder Pain 655 groove and resecting the proximal portion of the tendon with tenodesis of the distal portion into the groove or beneath the pectoralis tendon. Acromioclavicular Disorders The AC joint is a common source of shoulder pain. Acute causes of AC joint pain are often related to direct trauma of the affected shoulder that may result in a distal clavicle injury with an intra-articular chondral fracture, or in AC joint instability from ligamentous disruption. 122 Post-traumatic distal clavicle osteolysis, with resorption of the distal clavicle, may ensue 4 weeks after a shoulder injury, leading to AC joint pain. 123,124 Osteolysis may be caused by microfracture of the subchondral bone and subsequent attempts at repair. 125 Other authors believe the cause to be an autonomic nerve dysfunction affecting the blood supply to the clavicle. The increased blood supply leads to resorption of bone from the distal clavicle. 123,126 More commonly, chronic osteolysis results from repetitive microtrauma to the AC joint from activities such as weight lifting, gymnastics, and swimming. 125,127,128 The underlying pathophysiology is believed to be an inflammatory process caused by stress fracture of the subchondral bone with hyperemic resorption of the distal clavicle. 125,129 Other causes of osteolysis include rheumatoid arthrosis, hyperparathyroidism, and sarcoidosis, which should be considered in the differential diagnosis, especially in bilateral cases. 123,124 Patients with atraumatic osteolysis of the distal clavicle should be forewarned that bilateral involvement may occur; an incidence of 70% was reported for one long-term follow-up. 130 Other chronic causes of AC pain include idiopathic, intra-articular disk pathology, posttraumatic degenerative arthrosis from joint incongruity, primary degenerative arthrosis, and rheumatoid arthrosis. Evaluation should always include a detailed history, physical examination, and radiographic evaluation. A history of trauma to the AC joint from a direct fall or blow to the ipsilateral shoulder may be reported. Less commonly, the AC joint may have been injured indirectly, as during a fall on the outstretched arm with forces transmitted through the arm to the AC joint. 122,131 Patients with osteolysis of the distal clavicle sometimes give a history of acute trauma, although the more common cause is repetitive microtrauma to the AC joint caused by activities such as weight lifting or gymnastics. 123,124,127,128 Patients frequently complain of pain over the AC joint when adducting the ipsilateral shoulder, such as during a golf swing or when buckling a seat belt. Often, pain occurs when sleeping on the affected shoulder. Athletes may experience AC joint pain on bench pressing, push-ups, and dips. 130,132,133 Pain and weakness of the affected shoulder also may be experienced with forward flexion and adduction of the arm. 123 On physical examination, a visible step-off may be observed between the medial acromion and the distal clavicle, indicating a probable AC separation. Pain usually can be elicited on direct palpation of the AC joint and is made worse by a cross-arm adduction maneuver. This test is performed by internally rotating the arm, which is maximally adducted across the chest, and is considered positive if pain is produced in the AC joint (see Figure 46-3D). Pain also may be elicited by moving the arm from a horizontally abducted position to the extended position and on maximal internal rotation of the shoulder. 132,134 These tests cause rotation and compression of the AC joint and are sensitive but less specific. They also may be positive with other disorders of the shoulder, such as posterior capsular stiffness. 135 Frequently, AC joint pain coexists with subacromial impingement and rotator cuff pathology. In these cases, impingement signs are positive, and rotator cuff weakness may be present. Otherwise, no muscle weakness should be detectable on manual resistance testing, and no evidence of muscle atrophy should be found. 130,135,136 The AC joint and the subacromial space may have to be injected on separate occasions to determine the true source of the symptoms. Some physicians have noticed an association of AC joint symptoms with shoulder instability. 130 Glenohumeral motion can vary, depending on chronicity and isolation of the problem to the AC joint. In isolated cases, some loss of internal rotation of the affected shoulder may be caused by pain. Radiographs should include anteroposterior views of the shoulder in the scapular plane in neutral, internal, and external rotation; a transcapular Y view; an axillary view; and a 15-degree cephalic tilt view of the AC joint at 50% penetrance, as described by Zanca (see Figure 46-4). 23 Stress views may be obtained by strapping 5 to 10 lb of weight to the forearms and determining AC separation. Comparing the coracoclavicular distance of both shoulders also may be helpful. When clinically indicated, cervical spine radiographs should be obtained to exclude cervical spondylosis. Radiographic evaluation may reveal AC joint arthrosis with microcystic changes in the subchondral bone, sclerosis, osteophytic lipping, and joint space narrowing. 137 In cases of osteolysis, radiographs may reveal loss of subchondral bone detail with microcystic appearances in the subchondral region of the distal clavicle and osteopenia of the lateral one-third of the clavicle. 124,125,127,128 In late stages of osteolysis, resorption of the distal end of the clavicle results in marked widening of the AC joint and sometimes complete resorption of the distal clavicle. AC separation may be evident with widening of the coracoclavicular distance and post-traumatic ossification of the coracoclavicular ligaments. AC symptoms do not always correlate with the radiographic appearance of the joint. DePalma 138 found AC joint degeneration to be an age-related process, with symptoms not always correlating with radiographic findings of AC joint arthrosis. 23 AC joint pain may occur despite normal radiographs. 139 A technetium 99m phosphate bone scan may assist in the diagnosis, revealing increased uptake in the distal clavicle and the medial acromion. 125 In cases of atraumatic osteolysis of the distal clavicle, increased uptake may be isolated to the distal clavicle, but in approximately 50% of cases, scintigraphic activity of the adjacent medial acromion is increased. 130 The bone scan may reveal pathologic changes in the AC joint when plain radiographs appear normal. In selected cases, MRI can be valuable in determining a diagnosis and evaluating the glenohumeral and subacromial regions for coexisting pathology (Figure 46-15). AC joint involvement may reveal increased fluid with synovitis, soft

18 656 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN clavicle has been described with results similar to open resection. 13,129, , Figure Sagittal section magnetic resonance imaging of the shoulder in a 32-year-old weight lifter complaining of shoulder pain. Fat-suppressed proton density fast spin echo images of bursal-side highgrade partial cuff tear (arrowheads). tissue enlargement, and periarticular ossifications with encroachment on underlying bursal and cuff tissue. Patients with AC joint pain usually respond well to nonoperative treatment; however, complete relief of symptoms may require an extended period. Conservative therapy includes heat, NSAIDs, steroid injections, shoulder rehabilitation, and avoidance of painful positions and activities. Steroid injections are repeated at 3-month intervals if painful conditions persist. Open resection of the distal clavicle for chronic AC joint pain was initially reported by Gurd 140 and by Mumford, 141 both with good results. Since that time, other surgeons have reported similar good results with open resection, but significant morbidity, such as disruption of the deltotrapezial fascia and anterior deltoid rupture, can occur. 123,124,137,139,142 Arthroscopic resection of the distal Glenohumeral Disorders The various arthritides that affect the shoulder joint are discussed in detail in other chapters. They are presented here to address aspects that are unique to the glenohumeral joint. The usual presentation of intra-articular disorders consists of pain with motion and symptoms of internal derangement, such as locking and clicking. Pain is generalized throughout the shoulder girdle and sometimes is referred to the neck, back, and upper arm. The usual response to pain includes decreased glenohumeral motion and substitution with increased scapulothoracic mobility. Patients with adequate elbow and scapulothoracic motion require little glenohumeral motion for activities of daily living; patients with glenohumeral arthrodesis can achieve adequate function. 147,148 The response to pain consists of diminution of motion and secondary soft tissue contractures with muscle atrophy. With increasing weakness and involvement of adjacent joints, pain, limitation of motion, and weakness can cause a substantial functional deficit. Inflammatory Arthritis Although the most common inflammatory arthritis involving the shoulder joint is rheumatoid arthritis (RA), other systemic disorders, such as systemic lupus erythematosus, psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and scleroderma, may cause glenohumeral degeneration. Motion is limited by splinting of the joint with secondary soft tissue contractures, or by primary soft tissue involvement with scarring or rupture. Plain radiographs confirm glenohumeral involvement (Figure 46-16A). Narrowing of the glenohumeral joint space may occur, with erosion and cyst formation and without significant sclerosis or osteophytes. As the disease progresses, superior and posterior erosion of the glenoid with proximal subluxation of the humeral head may occur. Eventually, secondary degenerative changes and even osteonecrosis of the humeral head may occur. A B Figure Plain radiographs. A, Rheumatoid arthritis with loss of joint space, cyst formation, glenohumeral erosion, and early proximal subluxation of the humerus, indicating a rotator cuff tear. B, Osteoarthritis with narrowing of the glenohumeral joint space, sclerosis, and osteophyte formation. Notice the preservation of the subacromial space, suggesting an intact rotator cuff.

19 CHAPTER 46 Shoulder Pain 657 Treatment is initially conservative and is directed toward controlling pain, inducing a systemic remission, and maintaining joint motion through physical therapy. The use of intra-articular glucocorticoids may be beneficial in controlling local synovitis. In rheumatoid arthritis, the involvement of periarticular structures with subacromial bursitis and rupture of the rotator cuff magnifies the functional deficit. When synovial cartilage interactions produce significant symptoms and radiographic changes that cannot be controlled by conventional therapy, glenohumeral resurfacing should be considered. When following an RA patient with shoulder involvement, the rheumatologist should assess range of motion carefully and should obtain periodic radiographs. Patients with progressive loss of motion or radiographic destruction should be referred for evaluation for possible surgical treatment. The treatment of choice is an unconstrained total shoulder arthroplasty. 149,150 Total shoulder arthroplasty is best performed in patients with rheumatoid arthritis before end-stage bony erosion and soft tissue contractions have occurred. 151,152 Acute inflammatory arthritis of the glenohumeral joint may be associated with gout, pseudogout, hydroxyapatite deposition of renal osteodystrophy, and recurrent hemophilic hemarthrosis. Osteoarthritis Osteoarthritis of the glenohumeral joint is less common than that in the hip, its counterpart in the lower extremity; this condition is caused by non weight-bearing characteristics of the shoulder joint and the distribution of forces throughout the shoulder girdle. Osteoarthritis is divided into conditions associated with high unit loading of articular cartilage and conditions in which an intrinsic abnormality within the cartilage causes abnormal wear at normal loads. Because the shoulder is normally a non weight-bearing joint and is not usually susceptible to repeated high loading, the presence of osteoarthritis of the glenohumeral joint should alert the physician to consider other factors. Has the patient engaged in unusual activities, such as boxing, heavy construction, or long-term use of a pneumatic hammer? Has some disorder, such as epiphyseal dysplasia, created joint incongruity with high unit loading of the articular cartilage? Is this a neuropathic process caused by diabetes, syringomyelia, or leprosy? Have associated hemochromatosis, hemophilia, or gout altered the ability of articular cartilage to withstand normal loading? Is unrecognized chronic dislocation responsible? Pain is the usual presentation, but generally it is not as acute or it may be associated with the spasm seen in inflammatory conditions. Plain radiographs show narrowing of the glenohumeral joint, osteophyte formation, sclerosis, and some cyst formation (Figure 46-16B). Because the rotator cuff usually is intact, less bone erosion of the glenoid and proximal subluxation of the humerus is noted. Patients with osteoarthritis of the glenohumeral joint frequently do well with functional adjustments and conservative therapy. Analgesics and NSAIDs may provide symptomatic relief. The use of glucocorticoid injections is less beneficial, unless evidence of synovitis is observed. Patients with severe involvement who fail to respond are best treated by shoulder arthroplasty Osteonecrosis Osteonecrosis of the shoulder refers to necrosis of the humeral head seen in association with a variety of conditions. Symptoms are due to synovitis and joint incongruity resulting from resorption, repair, and remodeling. Pathogenesis and various causes are discussed in Chapter 103. The most common cause of osteonecrosis of the shoulder is avascularity resulting from a fracture through the anatomic neck of the humerus. 153 Fracture through this area disrupts intramedullary and capsular blood supplies to the humeral head. 154 Another common cause of osteonecrosis of the shoulder is steroid therapy provided in conjunction with organ transplantation, systemic lupus erythematosus, or asthma. Other conditions associated with osteonecrosis of the humeral head include hemoglobinopathies, pancreatitis, and hyperbarism. Early diagnosis is difficult because the presence of symptoms is often delayed. Bone scans may be helpful in early cases, before radiographic changes are evident. MRI is highly sensitive and is more specific than scintigraphy. Plain radiographs show progressive phases of necrosis and repair (as discussed in Chapter 103). In early stages, the films may be normal or may show osteopenia or bone sclerosis. A crescent sign representing subchondral fracture or demarcation of the necrotic segment appears during the reparative process. Patients who fail to remodel show collapse of the humeral head with secondary degenerative changes. A considerable discrepancy is often noted between symptoms and radiographic involvement. Patients with extensive bone changes may be asymptomatic. Treatment should be directed by the patient s symptoms rather than by the radiographs and is similar to that provided for osteoarthritis. Arthroscopy occasionally is helpful by removing loose chondral fragments and débriding chondral incongruities. 155 Patients with severe symptoms that cannot be controlled by conservative means are best treated with unconstrained shoulder arthroplasty, hemiarthroplasty, or resurfacing arthroplasty. 149 Cuff-Tear Arthropathy In 1873, Adams described the pathologic changes that characterize rheumatoid arthritis of the shoulder and a condition that has since that time been referred to as Milwaukee shoulder or cuff-tear arthropathy. 156 McCarty called the condition Milwaukee shoulder and reported that factors predisposing to this syndrome included deposition of calcium pyrophosphate dihydrate crystals, direct trauma, chronic joint overuse, chronic renal failure, and denervation. 157 Patients with Milwaukee shoulder have elevated levels of synovial fluid 5-nucleotidase activity and elevated levels of synovial fluid inorganic pyrophosphate and nucleotide pyrophosphohydrolase activity. 158 Neer and colleagues 159 reported a similar condition in which untreated massive tears of the rotator cuff with proximal migration of the humeral head are associated with erosion of the humeral head. Erosion of the humeral head differs from that seen in other arthritides and is presumed to be caused by a combination of mechanical and nutritional factors acting on the superior glenohumeral cartilage.

20 658 PART 6 DIFFERENTIAL DIAGNOSIS OF REGIONAL AND DIFFUSE MUSCULOSKELETAL PAIN Patients with cuff-tear arthropathy present a difficult therapeutic problem because bone erosion and disruption of the cuff jeopardize the functional result from an unconstrained prosthesis. 151 Hemiarthroplasty or a reverse total shoulder arthroplasty may be indicated. 160,161 The major challenge in treating cuff-tear arthropathy is to determine which patients with massive rotator cuff tears will proceed to the syndrome of cuff-tear arthropathy. Patients with massive rotator cuff tears who develop localized calcium pyrophosphate disease may be predisposed to further proximal migration and further joint destruction. This situation poses a dilemma for the treating physician. Many patients with massive rotator cuff tears remain stable and require little or no treatment. Occasionally, symptomatic patients can be treated by arthroscopic débridement of the cuff tear. In a recent study, patients with massive rotator cuff tears without arthritis did well when treated with reverse total shoulder arthroplasty. 115 It is crucial to define the patient who will proceed to the syndrome of cuff-tear arthropathy. If crystal deposition disease predisposes patients to proximal migration and joint destruction, joint aspiration with crystal analysis and scintigraphy to determine synovial reaction may be helpful diagnostic tools. Hamada and co-workers 162 followed 22 patients with massive rotator cuff tears treated conservatively. Radiographic findings included narrowing of the acromiohumeral interval and degenerative changes in the humeral head, tuberosities, acromion, AC joint, and glenohumeral joint. Five of seven patients followed for longer than 8 years progressed to cuff-tear arthropathy. Investigators concluded that progressive radiographic changes were associated with repetitive use of the arm in elevation, rupture of the long head of the biceps, impingement of the humeral head against the acromion, and weakness of external rotation. 162 Septic Arthritis Septic arthritis can masquerade as any of the conditions classified as periarticular or glenohumeral disorders (see Chapters 99 and 110). Sepsis must be included in any differential diagnosis of shoulder pain because early recognition and prompt treatment are necessary to achieve a good functional result. The diagnosis is confirmed by joint aspiration with synovial fluid analysis and culture. Cultures should include aerobic, anaerobic, mycobacterial, and fungal studies. Labral Tears The glenoid labrum increases the depth of the glenoid and serves as an anchor for the attachment of the glenohumeral ligaments. Historically, labral tears have been difficult to diagnose. Findings on physical examination can be confused with impingement and rotator cuff tendinopathy and bicipital tendinitis. Diagnosis can be confirmed with MRIarthrography, CT-arthrography, and DCAT. 27 Arthroscopy has greatly increased our knowledge of the glenoid labrum in normal and pathologic situations and has aided clinicians in the diagnosis and treatment of labral lesions. Labral tears can be divided into tears associated with symptoms of internal derangement and tears associated with anterior or posterior instability. A soft tissue Bankart lesion is associated with a tear of the anterior band of the inferior glenohumeral ligament and with anterior instability. Isolated labral tears that do not involve detachment of the ligaments can cause internal derangement and may have an arthroscopic appearance similar to that of a meniscal tear of the knee. Andrews and associates 7 first described lesions of the anterior superior labrum in throwing athletes; these lesions were often associated with biceps tendon tears (10%), which may result from traction of the biceps tendon. Snyder and co-workers 163 introduced the term SLAP lesion in 1990 to describe an injury involving the long head of the biceps tendon and the superior portion of the glenoid labrum. The long head of the biceps tendon originates at the supraglenoid tubercle and the glenoid labrum in the superior-most portion of the glenoid. The major portion of the tendon blends with the posterior superior aspect of the labrum. The most common mechanism of a SLAP injury is a fall onto an outstretched arm with the shoulder in abduction and slight forward flexion. 163 The lesion also can result from acute traction on the arm and from an abduction and external rotation mechanism. 164,165 Patients usually complain of pain with overhead activities and a frequent catching or popping sensation in the shoulder. The most reliable diagnostic test is O Brien s test. The test is performed against resistance with the arm in forward flexion and with the elbow extended and the forearm pronated. In the second part of the test, the arm is supinated. Less pain during the latter part of the test suggests a SLAP lesion. 163 The most accurate diagnostic test is MRI-arthrography with gadolinium. 166 Treatment for symptomatic SLAP lesions is surgical. Adhesive Capsulitis Adhesive capsulitis, or frozen shoulder syndrome (FSS), is a condition characterized by limited motion of the shoulder joint with pain at the extremes of motion. It was first described by Putman 167 in 1882 and later by Codman. 1 The initial presentation is pain, which is generalized and is referred to the upper arm, back, and neck. As pain increases, loss of joint motion ensues. The process generally is selflimiting and in most cases resolves spontaneously within 10 months, unless an underlying problem is present. The exact cause of FSS is unknown. 92,168 It is frequently associated with conditions such as diabetes mellitus, parkinsonism, thyroid disorders, and cardiovascular disease. When one of these conditions exists, a history of some mild trauma that initiated the frozen shoulder is often reported. Major skeletal trauma and soft tissue injury may coexist with FSS. It also may be seen with a variety of other conditions, including apical lung tumor, pulmonary tuberculosis, cervical radiculopathy, and post myocardial infarction In one review of FSS, 3 of 140 patients with this syndrome had local primary invasive neoplasms. 172 Another study described 3 patients with adhesive capsulitis who subsequently were found to have a neoplastic lesion of the midshaft of the humerus. 173 In a high-risk patient with an underlying disorder, even minor surgery or trauma in a remote location, such as the hand, can precipitate FSS. 92,174,175